Abstract: Analogs of arachidonic acid are provided having the structure ##STR1## wherein R is CH.sub.2 OH or CO.sub.2 H and m is 1 or 2. These compounds are useful as inhibitors of leukotriene and prostaglandin biosynthesis and as such are useful an antiallergy and antiinflammatory agents.

Abstract: A catalytic synthesis of chromans in racemic or optically active forms, including intermediates thereto; the synthesis employs an asymmetric palladium (II) catalyzed oxidative cyclization of a 2-homoallylphenol and provides intermediates useful in making chromans, especially vitamin E in racemic or optically active forms.

Abstract: The invention is directed to a process and intermediates for the preparation of 1.alpha.,23(S),25-trihydroxycholecalciferol and 1.alpha.,23(R),25-trihydroxycholecalciferol. The end-products, 1.alpha.,23(S),25-trihydroxycholecalciferol and 1.alpha.,23(R),25-trihydroxycholecalciferol, are useful for the treatment of disease states which are characterized by insufficient amounts of 1,25 dihydroxycholecalciferol.

Abstract: A silyl-enol ether of the formula ##STR1## wherein n stands for the number and X stands for a group ##STR2## or n stands for the number 1 and X stands for the 6,11-dimethylhexadeca-2,4,6,8,10,12,14-heptaene-2,15-diyl group, the symbols R.sup.1 have the same or different significances and denote alkyl groups, and the symbol R.sup.2 represents a trialkylsiloxy group --OSi(R.sup.1).sub.3 or an ether group,is oxidized with percarboxylic acid and, if desired, the resulting .alpha.-siloxy ketone is hydrolyzed to an .alpha.-hydroxy ketone. This process is especially suitable for the manufacture of astaxanthin.

Abstract: The invention provides a novel class of organosilicon compounds useful as a curing agent in a room temperature curable organopolysiloxane composition, which is represented by the general structural formulaR.sub.2 CH--CR.dbd.C(OR)--O--Si(R.sup.1).sub.3-m (O--CR.dbd.CH--R).sub.m,in which each R is a hydrogen atom or a substituted or unsubstituted monovalent hydrocarbon group independently from the others, R.sup.1, if any, is a substituted or unsubstituted monovalent hydrocarbon group and the suffix m is 2 or 3. The compound can readily be synthesized by the reaction of an .alpha.,.beta.-unsaturated ester compound represented by the general formulaR.sub.2 C.dbd.CR--CO--OR,and an alkenyloxy-containing silane compound represented by the general formulaHSi(R.sup.1).sub.3-m (O--CR.dbd.CH--R).sub.m,in which R.sup.1, R and m each have the meaning as defined above, in the presence of a rhodium compound as a catalyst.

Abstract: What is disclosed is a composition of matter useful in expediting the coagulation of whole blood. The coagulation promoter is a polysiloxane which contains at least one hydroxy functional or carboxylic functional monovalent hydrocarbon radical bonded to a silicon atom.

Abstract: Mono- or bis(iodonium salts) are produced in neutral organic solvents by the reaction of an [hydroxy (organosulfonyloxy)iodo]arene with a bis(triorganosilyl)arene, a bis(trihalosilyl)arene, or with a mono- or bis(triorganosilyl)heterocyclic compound, or a mono- or bis(trihalosilyl)heterocyclic. The iodonium salts are made under conditions of regiospecific control.

Abstract: Compounds of Formula I ##STR1## wherein X is oxygen or CH.sub.2 ;A is CH.sub.2 --CH.sub.2, trans-CH.dbd.CH or C.tbd.C;W is free or functionally modified hydroxymethylene or free or functionally modified ##STR2## and the OH groups may be in the .alpha.- or the .beta.-position; D is straight chain or branched, saturated or unsaturated hydrocarbon aliphatic of from 1 to 10 carbon atoms, which may be substituted by fluorine;E is C.tbd.C or CR.sub.3 .dbd.CR.sub.4, R.sub.3 and R.sub.4 being different and being hydrogen or alkyl of 1 to 5 carbon atoms;R.sub.1 is free or functionally modified hydroxy; andR.sub.2 is alkyl, cycloalkyl, optionally substituted aryl or heterocyclic,have valuable pharmacological properties, e.g., hypotensive and bronchodilatory characteristics. They can furthermore be used for prophylaxis and therapy of coronary infarct and as a treatment for stroke. They are produced by means of reduction of the corresponding 1-carbonic acid derivatives.

Abstract: New acetylenic and allenic carbinols of formula ##STR1## respectively, wherein symbol R stands for a trialkyl-silyl or a C.sub.1 to C.sub.6 alkyl radical, preferably a methyl, a tert-butyl or an isoamyl radical, or a group of formula ##STR2## wherein, when taken separately, each of symbols R.sup.1 and R.sup.2 represents a lower alkyl radical or, when taken together, R.sup.1 and R.sup.2 represent a tetramethylene group, are useful intermediates for the preparation of .beta.-damascenone.

Abstract: Novel acetylenic compounds useful as starting materials for the preparation of .beta.-damascenone. Process for their preparation and use thereof.

Abstract: This invention relates to polymeric organosilicon compounds containing aryl radicals and to a method for improving the gliding or slipping properties of organic fibers treated therewith. The polymeric organosilicon compounds are represented by the formulaM.sub.a R.sub.b Si{[(OSiR.sub.2).sub.n D].sub.m (OSiR.sub.2).sub.n OSiR.sub.3-d M.sub.d }.sub.4-a-bin which R is hydrocarbon or substituted hydrocarbon radical, D represents radicals of the formula--X.sub.a A--X.sub.a (A--X.sub.a).sub.c --,X represents the groups: ##STR1## --NR'--, --O--, --S--, --SO.sub.2 --, --R"--, --NR'R", ##STR2## --OR"--, --SR"--, --SO.sub.2 R", where R' is hydrogen or R, R" is a bivalent aliphatic hydrocarbon radical, A is a bivalent or substituted bivalent aromatic hydrocarbon radical, M represents radicals of the formula--X.sub.a --A--X.sub.a (A--X.sub.a).sub.c H,a is 0 or 1, b is 0, 1 or 2, c is 0 or a number of from 1 to 5, m is 0 or a number of from 1 to 20, n is a number of from 1 to 1,000 with the proviso that at least one OSiP.

Abstract: Polymeric antioxidants comprising polyorganosiloxane backbones having joined thereto, by non-hydrolyzable linkages, aromatic antioxidant moieties.

Abstract: A compound of the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein: G is hydroxymethylene or carbonyl;R is hydrogen or alkanoyl having from one to seven carbon atoms;R.sub.1 and R.sub.2 are each methyl or ethyl;R.sub.3 is an alkyl of from five to seven carbon atoms;m is 0 or 1; andn is 1, 2 or 3.A preferred compound is one in which m is zero, n is one or G is hydroxymethylene. Also preferred are compounds in which R.sub.1 and R.sub.2 are methyl. Additional preferred compounds include those where R is hydrogen or acetyl. A preferred compound is Z-3-(4'-(dimethyl-n-hexylsilyl)-2'-hydroxyphenyl)cyclohexanol.The invention further comprises pharmaceutical compositions containing these compounds. In accordance with the present invention, these compounds when administered in an effective amount to mammals are useful as CNS agents including analgesics, tranquilizers, sedatives, anticonvulsants, antidiarrheals, antiemetics and antianxiety agents.

Abstract: Silylated trichloromethyl carbinol compounds are prepared by contacting aldehydes and ketones with silylated trichloroacetates at elevated temperatures in the presence of an initiator.

Abstract: Novel organic phenol-containing silicon compounds of the formula ##STR1## are disclosed. These compounds are suitable for use as lubricant additives.

Abstract: Surface-active polysiloxanes are disclosed having the formula: ##STR1## in which x denotes an integer from 3 to 10 and A denotes a cationic, anionic, zwitterionic or nonionic hydrophilic unit which contains one or more of the same or different groups which are amine, amine oxide, ammonium, ammonioalkylcarboxylate, ammonioalkylsulphonate, amide, sulphonamide, ether, thioether, sulphoxide, hydroxyl, ester or acid groups. These polysiloxanes are particularly useful for use in cosmetic and pharmaceutical compositions, especially compositions for the hair.

Abstract: Novel acetylenic compounds useful as starting materials for the preparation of .beta.-damascenone. Process for their preparation and use thereof.

Abstract: A synthesis of Vitamin E has the condensation of 2,4-pentanediene and 1,2-epoxy-2,6,10,14-tetramethylpentadecane including intermediates in this synthesis which uses base catalyzed condensations of aliphatic compounds to construct the Vitamin E molecule from aliphatic precursors.

Abstract: Homopolymers and copolymers of compounds according to the formula: ##STR1## wherein R is an alkyl having 1 to 3 carbons, a+b+c+d=e, b=O to e, c=O to e, b+c>1, d=0 to 5, e=1 to 100, and Y is an organic group containing at least one>C.dbd.C<are hydrophilic as well as exhibiting properties similar to silicone compounds. The polymers are particularly useful in contact lenses having enhanced oxygen permeability.

Abstract: Dihaloneopentyl silicates are solid compositions formed by esterification of silicon halides or silicate esters with dihaloneopentyl glycol. These compositions are useful as flame retardants in plastic formulations.

Abstract: According to the invention, the method for producing mineral polymer fillers containing graft hydroperoxide groups consists in treating mineral fillers at a temperature of 50.degree. to 150.degree. C. and a pressure of 1.33.10.sup.2 to 4.10.sup.5 Pa (1 mm Hg to 4 atm) with organosilicon compounds of the general formula:R.sub.4-y SiX.sub.yorR'R.sub.3-z SiX.sub.z,whereR is vinyl, allyl or norbornyl,X is chlorine, alkoxy or acyloxy,y=1-3,z=1-2,R' is methyl, ethyl or propyl,whereupon the mineral filler containing graft unsaturated groups is separated from the reaction mixture, dried and ozonized with an ozone-oxygen mixture containing 4 to 6 percent by volume of ozone at a temperature of -20.degree. C. to +20.degree. C. in an aliphatic saturated monohydric alcohol or aliphatic saturated monohydric acid.The method for producing mineral polymer fillers containing graft hydroperoxide groups is quite simple and makes it possible to carry out the filling and grafting of polymers at a reduced temperature of 50.degree.

Abstract: Derivatives, analogs, and congeners of prostane having a 1-(hydroxymethyl)-1-oxo-prostane structure in the F.sub.1 series.