Abstract: Disclosed is a process for producing a phosphine derivative from a phosphine oxide derivative, which comprises the following steps: (I) mixing a phosphine oxide derivative represented by formula (1) with a chlorinating agent in a polar organic solvent to cause the reaction between these components; and (II-1) adding a salt of a metal having an ionization tendency equal to or lower than that of aluminum to the reaction mixture and carrying out the reductive reaction in the presence of aluminum or (II-2) subjecting the reaction mixture to electrolytic reduction, thereby producing a phosphine derivative represented by formula (2). ArnR3-nP?O (1) ArnR3-nP (2) In formulae (1) and (2), Ar represents an aryl group such as a phenyl group, a phenyl group having a substituent, a heteroaromatic ring group, and a heteroaromatic ring group having a substituent; R represents an aliphatic hydrocarbon group or an aliphatic hydrocarbon group having a substituent; and n represents an integer of 0 to 3.

Abstract: This disclosure provides choline analogs comprising the following structure: where each R1 independently is H or isotopically enriched D, R2 is a protecting group, and N is 14N or isotopically enriched 15N. This disclosure also provides methods of making choline analogs, which include performing a protection step on a betaine aldehyde to form a choline analog, and methods of using choline analogs to form hyperpolarized compounds.

Abstract: A method for the manufacture of dialkyl phosphites by reacting a P—O component containing from 1 to 6 P—O—P bonds in the molecule, with an alcohol and a ketal corresponding to a selected formula, said ketal will not lead to the formation of an enol structure. The level of the ketal is expressed in relation to the level of co-reactants. A preferred ketal is void of any carbon-hydrogen bonds on the ?-carbon atom in the ketal structure.

Abstract: The present invention relates to a method of producing a polymerizable phosphate containing at least one selected from polymerizable phosphates represented by formula (II), (III) or (IV) by a batch reaction, including a step of adding a compound represented by formula (I) into a mixture of a polymerizable phosphate reaction product containing at least one selected from polymerizable phosphates represented by formula (II), (III) or (IV), obtained by a pre-batch reaction, and phosphoric acid anhydride to react them: wherein R1 represents H or a C1-4 alkyl group, R2 represents a C2-6 alkylene group and n denotes an integer from 1 to 3.

Abstract: The present invention relates to a novel process for the preparation of a sterically hindered nitroxyl ether from the corresponding sterically hindered nitroxyl radical by reacting it with a carbonyl compound and a hydroperoxide. The compounds prepared by this process are effective stabilizers for polymers against harmful effects of light, oxygen and/or heat, as flame-retardants for polymers and as polymerization regulators.

Abstract: The present invention relates to a method of producing a polymerizable phosphate containing at least one selected from polymerizable phosphates represented by formula (II), (III) or (IV) by a batch reaction, including a step of adding a compound represented by formula (I) into a mixture of a polymerizable phosphate reaction product containing at least one selected from polymerizable phosphates represented by formula (II), (III) or (IV), obtained by a pre-batch reaction, and phosphoric acid anhydride to react them: wherein R1 represents H or a C1-4 alkyl group, R2 represents a C2-6 alkylene group and n denotes an integer from 1 to 3.

Abstract: Reactions of Group 16 elements involving the addition of atoms such as sulfur, selenium or tellurium to organic or inorganic molecules comprising use of an ionic liquid as a reaction medium.

Abstract: Provided are processes and intermediates for preparation of rosuvastatin.

Abstract: A derivative of phosphoric acid ester salt or adduct or a mixture thereof is obtained from a reaction product, polycondensed with at least one aldehyde, of at least one polyol phosphoric acid ester with at least one organic nitrogen base. The derivative is advantageously used as a flame-inhibiting and/or intumescent treatment in plastic mouldings, on porous carriers or in paint or coating systems. The production of the derivative or a mixture thereof by reacting at least one polyol with phosphorus pentoxide and reacting the polyol phosphoric acid ester obtained in that way with at least one organic nitrogen base forming a phosphoric acid ester salt or adduct, is characterized in that the amount of phosphorus pentoxide required for the esterification operation is suspended in an amount of the ester or ester mixture to be produced, then at a temperature in the range of 20–180° C.

Abstract: Mechanochemical synthesis of pentaerythritol phosphate alcohol is disclosed. The synthesis is carried out by ball milling a mixture containing P2O5, pentaerythritol, an alkyl benzene having one or two C1-C5 alkyl groups, and a metal halide catalyst, in a ball mill as a reactor and at a temperature of 70-150° C.

Abstract: Provided are methods of producing phosphitylated compounds, including 3′-O-phosphoramidites, comprising the step of reacting a hydroxyl-containing compound with a phosphitylating agent in the presence of a phosphitylation activator selected from the group consisting of: (1) acid-base complexes derived from an amine base of Formula I 1

Abstract: An aryl group containing phosphite, such as triphenyl phosphite, can be added to a reaction mixture comprising an organophosphorus compound, phosphorus pentoxide and an alkylene oxide, optionally in the presence of a reagent for the incorporation of hydroxy functionality in the final product. The aryl group containing phosphite is employed to improve the color characteristics of the resulting oligomeric organophosphorus composition.

Abstract: The invention relates to a process for the preparation of mixtures of oligomeric phosphoric acid esters of the formula (I) ##STR1## in which n is a number from 0 to 8,R.sub.1, R.sub.2, R.sub.3 and R.sub.7 are identical or different and are a halogen-free alkyl or aryl radical or a hydroxyl-containing radical of the formula II and R.sub.4 is a radical of the formula III ##STR2## in which, in the formulae II and III, R.sub.5 and R.sub.6 are a hydrogen atom or an alkyl radical and m is a number from 1 to 4, which comprises reacting, in a first stage, aliphatic or araliphatic alcohols and/or phenols with phosphorus pentoxide (P.sub.4 O.sub.10) in a molar ratio of (2.8 to 6.0):1.0 (alcohol/phenol: P.sub.4 O.sub.10) at a temperature from 20.degree. to 100.degree. C. in the course of 0.5 to 72 hours, a polyphosphoric acid partial ester mixture of the formula V ##STR3## which R.sub.1 ', R.sub.2 ', R.sub.3 ' and R.sub.

Abstract: An unsaturated phosphonic ester is produced by reaction of an acetylene compound with a secondary phosphite in the presence of a palladium complex catalyst.

Abstract: Heterosubstituted acetals of the formula ##STR1## can be obtained by reacting vinyl compounds of the formulaCH.sub.2 .dbd.CH-A.sup.1 (II)with alkyl nitrites of the formulaR.sup.1 --ONO (III.)The reaction is performed in the presence of palladium in metallic or bonded form and in alcohols or ethers as reaction medium at from 0.degree. to 120.degree. C.

Abstract: A liquid aluminum phosphate salt gelling agent comprising the reaction product of: a dialkyl phosphate formed from the reaction product of (1) a polyphosphate intermediate produced by reacting triethyl phosphate and phosphorous pentoxide and (2) a mixture of aliphatic alcohols having 6 to 10 carbons in their alkyl groups; an aluminum sulfate; and a solvent.

Abstract: Surfactant compositions in an acidic or neutralized form containing a mixture of at least one polyoxyalkylenated phosphoric acid monoester and at least one polyoxyalkylenated diester and a nonionic polyoxyalkylenated compound wherein the phosphoric acid diester:phosphoric acid monoester molar ratio before neutralization, if carried out, is at least equal to 0.9:1 and the phosphoric acid monoester and phosphoric acid diester content is at least 1 mol %, preferably at least 50 mol % of said composition. The surfactant compositions are prepared by phosphatization of a nonionic polyoxyalkylenated compound at a temperature of from about 35.degree. to about 45.degree. C. followed by maturing at from about 40.degree. to about 60.degree. C., in a stirred turbulent state. The compositions are useful in the formulation of active substances in the form of microgranules and flowables.

Abstract: An improved hydrocarbon gelling agent is disclosed comprising the reaction product of (1) a polyphosphate intermediate produced by reacting triethyl phosphate and phosphorous pentoxide and (2) a mixed alcohol having a substantial hexanol component, together with methods of making and using such gelling agent.

Abstract: Amphoteric and zwitter-ionic phosphate surfactants corresponding to the following formula ##STR1## (a) in which R.sup.1 is a C.sub.6 -C.sub.22 alkyl group, a group R.sup.4 (OC.sub.n H.sub.2n).sub.x --, where n=2 to 4, x=1 to 6, and R.sup.4 is a C.sub.6 -C.sub.22 alkyl group, or a group R.sup.5 --CONH(CH.sub.2).sub.m, where R.sup.5 is a C.sub.5 -C.sub.21 group and m=2 to 4; R.sup.2 is hydrogen; and R.sup.3 is a C.sub.1 -C.sub.4 alkyl group or a group --(C.sub.n H.sub.2n O).sub.x --H or --(C.sub.n H.sub.2n O).sub.x --PO.sub.3 H.sub.2, where n=2 to 4 and x=1 to 6, or(b) in which R.sup.1 is a C.sub.1 -C.sub.4 alkyl group or a C.sub.2 -C.sub.4 2-hydroxyalkyl group; R.sup.2 is a C.sub.6 -C.sub.22 alkyl group; and R.sup.3 is as defined above.to mixtures thereof with correspondingly substituted phosphate surfactants corresponding to formula (I), in which the --PO.sub.3 H.sub.2 group or groups are replaced by hydrogen; and to neutral and basic salts of the foregoing.

Abstract: The present invention relates to microbiocidal cleansing agent and to a microbiocidal amine alkyl phosphate additive which is incorporated therein.The microbiocidal amine alkyl phosphate has the following general structure: ##STR1## wherein R=an alkyl group containing from 1 to 24 carbon atoms;R.sub.1 =an alkyl group containing from 1 to 3 carbon atoms; andR.sub.2 =an alkyl group containing from 1 to 5 carbon atoms.The microbiocidal cleansing agent of the present invention may be prepared by dissolving the amine alkyl phosphate additive in water or a conventional detergent.

Abstract: In a continuous alkoxidation-phosphorylation process for producing tributyl phosphate having low color utilizing excess butanol in the alkoxidation reaction which is heated by an alcohol flasher wherein the excess butanol is recovered after phosphorylation by two stage flash distillation, the bottoms product from the first stage going to the second stage, the overhead product from the second stage returning to the first stage flash distillation, and the bottoms from the second stage distillation going to final product washing and drying process while the overhead from the first stage flash distillation is fed to the process alkoxidation alcohol flasher, the improvement which comprises distilling in a distillation column the overhead product from the first stage flash distillation and then feeding the overhead from the distillation column to the alkoxidation alcohol flasher.