Forming A Linkage Wherein Divalent Chalcogen Is Bonded Directly To Two Phosphori (e.g., Forming The Pyrophosphate Linkage, Etc.) Patents (Class 558/127)
Abstract: This invention relates to a method for preparing 4-substituted-4-cyanocyclohexane carboxylates by forming the cyclohexane ring by treating a &agr;,&agr;-bis(2-haloethyl)-4-benzeneacetonitrile with a dialkyl malonate and decarboxylating the resulting diester.
Type:
Grant
Filed:
April 2, 2002
Date of Patent:
May 25, 2004
Assignee:
SmithKline Beecham Corporation
Inventors:
Ann M. Diederich, Ann Marie Eldridge, Robert J. Mills, Vance J. Novack
Abstract: A flame retardant composition is produced by mixing a flammable organic material with an organic phosphorus-inorganic phosphorus oxyacid compound or its salts. The organic phosphorus-inorganic phosphorus oxyacid compounds are produced by reacting an organic phosphorus compound with an inorganic phosphorus oxyacid. The organic phosphorus-inorganic phosphorus oxyacid compound may be reacted with a basic salt forming compound. The flammable organic material such as thermoplastic resins are made less flammable by melting-kneading the flammable material with the organic phosphorus-inorganic phosphorus oxyacid compound or it's basic salt, carbonization auxiliaries, a metal-containing compound having a carbonization acceleration effect, a comb-like polymer and a filler.
Abstract: A process for the preparation of glycerol di- or triphosphate derivatives comprising coupling the phosphate group of a glycerol monophosphate derivative in which one of the phosphate hydroxyls is replaced by a leaving group, with the terminal phosphate group of a mono- or diphosphate compound or a salt thereof, in the presence of a basic catalyst, under anhydrous conditions.
Type:
Grant
Filed:
May 31, 1994
Date of Patent:
July 14, 1998
Assignee:
NeXstar Pharmaceuticals, Inc.
Inventors:
Henk van den Bosch, Gysbert M. T. van Wijk, Raj Kumar, Karl Y. Hostetler
Abstract: Glycol bisphosphate compounds are formed by first hydrolytically condensing a dihydrocarbylhalophosphate to form a tetrahydrocarbyl pyrophosphate and then reacting the pyrophosphate with a cyclic ether to form the glycol bisphosphate.