Forming Phosphorus To Chalcogen Bond Patents (Class 558/132)
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Patent number: 9035083Abstract: The esterfication of hypophosphorous acid is followed by reaction with another molecule of alcohol under the action of a nickel catalyst to provide a green method for the preparation of H-phosphonate diesters. This method avoids the need for any stoichiometric chlorine unlike those based on phosphorous trichloride.Type: GrantFiled: March 21, 2014Date of Patent: May 19, 2015Assignee: Texas Christian UniversityInventors: Jean-Luc Montchamp, Henry C. Fisher
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Publication number: 20140303394Abstract: The esterfication of hypophosphorous acid is followed by reaction with another molecule of alcohol under the action of a nickel catalyst to provide a green method for the preparation of H-phosphonate diesters. This method avoids the need for any stoichiometric chlorine unlike those based on phosphorous trichloride.Type: ApplicationFiled: March 21, 2014Publication date: October 9, 2014Applicant: Texas Christian UniversityInventors: Jean-Luc Montchamp, Henry C. Fisher
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Publication number: 20140296187Abstract: A method for preparing plasmalogens and derivatives thereof represented by Formula B, wherein R1 and R2 are similar or different, derived from fatty acids; R3 is selected from hydrogen and small alkyl groups. The synthetic route involves production of novel cyclic plasmalogen precursors of Formula A and their conversion to plasmalogens and plasmalogen derivatives of Formula B. Also disclosed is the therapeutic use of plasmalogens and derivatives thereof as produced by the synthetic route of the present invention.Type: ApplicationFiled: November 16, 2012Publication date: October 2, 2014Inventors: M. Amin Khan, Paul L. Wood, Dayan Goodenowe
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Patent number: 8846967Abstract: The present invention relates to a process for preparing tetraalkyl bisphosphates by reacting tetrachlorobisphosphates with alcohols, neutralizing the resultant hydrogen chloride with a base, and isolating the desired product from the reaction mixture by extraction.Type: GrantFiled: January 13, 2012Date of Patent: September 30, 2014Assignee: LANXESS Deutschland GmbHInventor: Jan-Gerd Hansel
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Publication number: 20140051879Abstract: Novel biodegradable phosphoester polyamines are disclosed. The biodegradable phosphoester polyamines may be utilized as cross-linkers for sprayable compositions which may be used as tissue adhesives or sealants.Type: ApplicationFiled: October 24, 2013Publication date: February 20, 2014Applicant: Covidien LPInventors: Nadya Belcheva, Ahmad Robert Hadba
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Publication number: 20140024734Abstract: The present invention relates to halogen-free oligomer mixtures of poly(alkylene phosphates), production of these and use as flame retardants, and also to flame-retardant polyurethanes comprising halogen-free oligomer mixtures as flame retardants.Type: ApplicationFiled: July 15, 2013Publication date: January 23, 2014Inventors: Jan-Gerd HANSEL, Heiko TEBBE
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Publication number: 20120184766Abstract: The present invention relates to a process for preparing tetraalkyl bisphosphates by reacting tetrachlorobisphosphates with alcohols, neutralizing the resultant hydrogen chloride with a base, and isolating the desired product from the reaction mixture by extraction.Type: ApplicationFiled: January 13, 2012Publication date: July 19, 2012Applicant: LANXESS DEUTSCHLAND GMBHInventor: Jan-Gerd Hansel
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Publication number: 20120184765Abstract: The present invention relates to a process for preparing tetraalkyl bisphosphates by reacting tetrachlorobisphosphates with alcohols, neutralizing the resultant hydrogen chloride with a base, and isolating the salt formed in the neutralization from the reaction mixture as a solid.Type: ApplicationFiled: January 13, 2012Publication date: July 19, 2012Applicant: LANXESS DEUTSCHLAND GMBHInventors: Jan-Gerd Hansel, Oliver Falkner
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Publication number: 20100137258Abstract: The invention relates to thiophosphi(o)nic acid derivatives having formula (I) wherein. M is a [C(R3,R4)]n1-C(E,COOR1,N(H,Z)) group, or an optionally substituted Ar—CH(COOR1,N(H,Z)) group (Ar designating an aryl or an heteroaryl group), or an ?, ? cyclic aminoacid group such as, formula (II) or a ?, &ggr;-cyclic aminoacid group such as, formula (III).Type: ApplicationFiled: August 1, 2008Publication date: June 3, 2010Inventors: Francine Acher, Chelliah Selvam, Jean-Philippe Pin
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Patent number: 7022868Abstract: This invention is an aminostyrylanthracene compound represented by, for example, the following general formula [I]. This compound is produced by condensation from a corresponding aminobenzaldehyde and a phosphonic ester or phosphonium salt. [where, in the general formula [I] above, R2 represents an unsubstituted aryl group, R1 represents an aryl group which may have a variety of substituents, and R3 to R5 each represent a hydrogen atom, a cyano group, or a hydrocarbon group.Type: GrantFiled: May 8, 2003Date of Patent: April 4, 2006Assignee: Sony CorporationInventors: Mari Ichimura, Tadashi Ishibashi, Shinichiro Tamura
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Patent number: 6608212Abstract: The present invention provides a process for preparing a vinylaromatic compound comprising reacting an arylmetal reagent selected from arylmagnesium reagents and aryllithium reagents with a vinylphosphate in the presence of a palladium catalyst. The present invention also provides a process for preparing a vinylphosphate comprising reacting an enolizable ketone with a sterically hindered Grignard reagent and a halophosphate diester.Type: GrantFiled: June 4, 2002Date of Patent: August 19, 2003Assignees: Pfizer, Inc., DSM NVInventor: Joseph Miller
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Patent number: 6284909Abstract: Improved methods for converting phosphite or phosphonate esters into corresponding thiophosphites or thiophosphonates and for synthesizing specific thiophosphite and thiophosphonate compounds so produced are disclosed and claimed. The methods start from phosphite diesters using P4S10 as the thionation reagent. The reaction mixture is refluxed until the reaction is complete and may be followed by separation and chloroformate ester phosphonation steps to produce pure thiophosphonocarboxylate triesters. Alternatively, these esters may be prepared directly by action of P4S10 on the corresponding phosphonocarboxylate esters. The former method was used to prepare dimethyl thiophosphite and thence trimethyl thiophosphonoformate, a key intermediate in synthesis of salts of thiophosphonoformic acid, which have anti-viral properties.Type: GrantFiled: November 1, 2000Date of Patent: September 4, 2001Assignee: University of Southern CaliforniaInventors: Charles E. McKenna, Zengmin Li
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Patent number: 6147244Abstract: Improved methods for converting phosphite or phosphonate esters into corresponding thiophosphites or thiophosphonates and for synthesizing specific thiophosphite and thiophosphonate compounds so produced are disclosed and claimed. The methods start from phosphite diesters using P.sub.4 S.sub.10 as the thionation reagent. The reaction mixture is refluxed until the reaction is complete and may be followed by separation and chloroformate ester phosphonation steps to produce pure thiophosphonocarboxylate triesters. Alternatively, these esters may be prepared directly by action of P.sub.4 S.sub.10 on the corresponding phosphonocarboxylate esters. The former method was used to prepare dimethyl thiophosphite and thence trimethyl thiophosphonoformate, a key intermediate in synthesis of salts of thiophosphonoformic acid, which have anti-viral properties.Type: GrantFiled: May 3, 1999Date of Patent: November 14, 2000Assignee: University of Southern CaliforniaInventors: Charles E. McKenna, Zengmin Li
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Patent number: 5929226Abstract: The invention provides improved oligonucleotides having greater resistance to nucleolytic degradation by virtue of having alkylphosphonothioate or arylphosphonothioate internucleotide linkages.Type: GrantFiled: May 8, 1995Date of Patent: July 27, 1999Assignee: Hybridon, Inc.Inventors: A. Padmapriya, Sudhir Agrawal
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Patent number: 5780617Abstract: A process for the preparation of glycerol di- or triphosphate derivatives comprising coupling the phosphate group of a glycerol monophosphate derivative in which one of the phosphate hydroxyls is replaced by a leaving group, with the terminal phosphate group of a mono- or diphosphate compound or a salt thereof, in the presence of a basic catalyst, under anhydrous conditions.Type: GrantFiled: May 31, 1994Date of Patent: July 14, 1998Assignee: NeXstar Pharmaceuticals, Inc.Inventors: Henk van den Bosch, Gysbert M. T. van Wijk, Raj Kumar, Karl Y. Hostetler
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Patent number: 5723645Abstract: Disclosed herein is a method for preparing 3-aminopropane phosphoric acid represented by the formula (I), comprising the steps of (a) reacting 3-amino-1-propanoi with phosphorus oxychloride at a low temperature, and (b) hydrolyzing the product of the step (a) in the presence of an acidic catalyst, and a cosmetic composition containing 3-aminopropanic phosphoric acid or its salts as an active ingredient.Type: GrantFiled: November 4, 1996Date of Patent: March 3, 1998Assignee: Pacific CorporationInventors: Ok Sub Lee, Young Hun Byon, Bo Sub Lee, Jong Eon Hong, Jae Suk Ko, Yun Ki Cho, Ho Lee
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Patent number: 5663442Abstract: The invention relates to a process for the preparation of compounds of the formula ##STR1## characterized in that the radical X in sulphones of the formulaX--(CH.sub.2 --CH.sub.2 --O).sub.m --(CH.sub.2).sub.n --SO.sub.2 --CH.sub.2 --CH.sub.2 OH (2)is replaced by ##STR2## or a compound of the formula ##STR3## is added to the sulphone of the formulaCH.sub.2 =CH--SO.sub.2 --CH.sub.2 --CH.sub.2 --OH (3),the substituents having the meanings given in the description.Type: GrantFiled: May 31, 1995Date of Patent: September 2, 1997Assignee: Bayer AktiengesellschaftInventors: Wolfgang Harms, Udo-Winfried Hendricks, Karl-Josef Herd, Klaus Kunde
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Polyphosphazene derivatives containing carbonyl groups and variously alkylated tertiary amino groups
Patent number: 5260103Abstract: Polyphosphazene derivatives containing carbonyl groups and variously alkylated tertiary aminic groups, suited to undergo rapid and efficient photo-crosslinking processes and having general formula: ##STR1## wherein: X represents substituents linked to the polyphosphazene chain by means of hydroxylic or aminic functions and containing carbonyl groups;X' represents additional substituents linked to the polyphosphazene chain by means of hydroxylic or aminic functions and containing one or more variously alkylated tertiary aminic groups;(w+y+z) is an integer ranging from 20 to 15,000;w and z are integers having a value higher than or equal to zero and at any rate lower than 15,000;y is an integer having a value of from 20 to 15,000.Type: GrantFiled: July 17, 1990Date of Patent: November 9, 1993Assignee: Consiglio Nazionale Delle RicercheInventors: Mario Gleria, Francesco Minto, Lucia Flamigni -
Patent number: 4670193Abstract: A process for preparing phosphonic acids of the structure ##STR1## wherein R.sub.1 is lower alkyl, aryl, cycloalkyl or arylalkyl, and R.sub.2 is H, benzyl or ##STR2## by oxidizing the corresponding phosphonous acid ##STR3## employing as the oxidizing agent potassium permanganate or sodium periodate.Type: GrantFiled: May 12, 1986Date of Patent: June 2, 1987Assignee: E. R. Squibb & Sons, Inc.Inventor: John K. Thottathil