Utilizing Oxirane Ring Containing Compound Patents (Class 558/143)
  • Phosphate ester flame retardants from resorcinol-ketone reaction products
    Patent number: 7365113
    Abstract: Flavan-based and spirodichroman compound-based phosphate esters prepared by reacting flavans and spirodichroman compounds with phosphorus oxychloride, monophenyl dichlorophosphate, or diphenyl chlorophosphate compounds are described. The flavans and spirodichroman compounds can be synthesized by the reaction of resorcinol with aliphatic acetone. Such phosphate esters can be used as flame retardants.
    Type: Grant
    Filed: September 21, 2005
    Date of Patent: April 29, 2008
    Inventors: Raj B. Durairaj, Gary A. Jesionowski
  • Nitrate esters and methods of making same
    Patent number: 6677374
    Abstract: Compounds and methods for mitigating neurodegeneration, effecting neuroprotection and/or effecting cognition enhancement in a subject are described. Neurological or cognitive conditions are treated by administering to a subject an effective amount of a therapeutic compound comprising a nitrate ester, or a pharmaceutically acceptable salt or ester thereof.
    Type: Grant
    Filed: March 29, 2002
    Date of Patent: January 13, 2004
    Assignee: Queen's University at Kingston
    Inventors: Gregory R. J. Thatcher, Brian M. Bennett, James N. Reynolds, Roland J. Boegman, Khem Jhamandas
  • Nitrate esters and their use for neurological conditions
    Patent number: 5883122
    Abstract: Aliphatic nitrate esters having a sulfur or phosphorus atom .beta. or .gamma. to a nitrate group and their congeners having efficacy as neuroprotective agents are described. Preferred nitrate esters may be synthesized by nitration of a 3-bromo-1,2-propanediol, and subsequent reaction to yield the desired mono-, di- or tetra-nitrate ester.
    Type: Grant
    Filed: June 3, 1997
    Date of Patent: March 16, 1999
    Assignee: Queen's University at Kingston
    Inventors: Gregory R. J. Thatcher, Brian M. Bennett, James N. Reynolds, Roland J. Boegman, Khem Jhamandas
  • Mono (2-ammonium-2-hydroxymethyl-1,3-propanediol) (2R,cis)-1,2-epoxypropyl-phosphonate with improved characteristics of stability and processing
    Patent number: 5191094
    Abstract: A process is described for the preparation of mono (2-ammonium-2-hydroxymethyl-1,3-propanediol) (2R,cis)-1,2-epoxypropyl-phosphonate with improved characteristics of stability, of processing for the preparation of pharmaceutical forms and of stability of the pharmaceutical forms that contain it.
    Type: Grant
    Filed: June 11, 1992
    Date of Patent: March 2, 1993
    Assignee: Zambon Group S.p.A.
    Inventors: Dario Tentorio, Graziano Castaldi, Claudio Girodano, Franco Pozzi
  • Process for the preparation of intermediates for the synthesis of fosfomycin
    Patent number: 4937367
    Abstract: A process is described for the preparation of intermediates useful in the synthesis of Fosfomycin.More particularly, an enantioselective process is described for the preparation of derivatives of (1S,2S)-1,2-dihydroxypropyl-phosphonic acid of formula ##STR1## wherein R.sub.2 and R.sub.3 have the meanings reported in the specification.
    Type: Grant
    Filed: July 12, 1988
    Date of Patent: June 26, 1990
    Assignee: Zambon Group S.p.A.
    Inventors: Graziano Castaldi, Claudio Giordano