Abstract: Provided is a method for separating the four optical isomers of Nahlsgen.

Abstract: An anti-aging composition, having anti-oxidant and anti-inflammatory properties, comprised of an effective amount of Turmeric Root Extract, Olive Leaf Extract, Grape Seed Extract, and Rosemary Leaf Extract to regulate and slow the signs of skin aging and tired looking skin. The composition also includes characteristics that may help to prevent cancer. The composition implements liposomal technology, using phosphatidylcholine, to surround the active ingredients with lipid molecules, thereby increasing the bioavailability of the present composition.

Abstract: Activated fatty acids, pharmaceutical compositions including activated fatty acids, methods for using activated fatty acids to treat a variety of diseases, and methods for preparing activated fatty acids are provided herein.

Abstract: A process for producing a purified O-(2,6-dichloro-4-methylphenyl)-O,O-dimethyl phosphorothioate, the process comprising: the first step of bringing a crude O-(2,6-dichloro-4-methylphenyl)-O,O-dimethyl phosphorothioate into contact with an acid; and the second step of recovering the purified O-(2,6-dichloro-4-methylphenyl)-O,O-dimethyl phosphorothioate from the mixture obtained in the first step.

Abstract: The present invention relates to I- and II-type crystals of L-?-glyceryl phosphoryl choline, and to a method for preparing same. More particularly, the present invention relates to noble I- and II-type anhydride crystals of L-?-glyceryl phosphoryl choline, which have a higher purity than conventional liquid L-?-glyceryl phosphoryl choline, and one advantage of which is that formulations and dosages of pharmaceuticals are easily modified, and another advantage of which is that the hygroscopicity of the crystals are much lower than that of conventional polymorphic crystals, providing excellent stability during storage. The present invention also relates to a method for preparing the I- and II-type crystals of L-?-glyceryl phosphoryl choline. The I-type crystal of L-?-glyceryl phosphoryl choline is characterized by having an onset temperature of 147° C. and an absorption peak of 150° C.

Abstract: The present invention relates to I- and II-type crystals of L-?-glyceryl phosphoryl choline, and to a method for preparing same. More particularly, the present invention relates to noble I- and II-type anhydride crystals of L-?-glyceryl phosphoryl choline, which have a higher purity than conventional liquid L-?-glyceryl phosphoryl choline, and one advantage of which is that formulations and dosages of pharmaceuticals are easily modified, and another advantage of which is that the hygroscopicity of the crystals are much lower than that of conventional polymorphic crystals, providing excellent stability during storage. The present invention also relates to a method for preparing the I- and II-type crystals of L-?-glyceryl phosphoryl choline. The I-type crystal of L-?-glyceryl phosphoryl choline is characterized by having an onset temperature of 147° C. and an absorption peak of 150° C.

Abstract: The present invention relates to I- and II-type crystals of L-?-glyceryl phosphoryl choline, and to a method for preparing same. More particularly, the present invention relates to noble I- and II-type anhydride crystals of L-?-glyceryl phosphoryl choline, which have a higher purity than conventional liquid L-?-glyceryl phosphoryl choline, and one advantage of which is that formulations and dosages of pharmaceuticals are easily modified, and another advantage of which is that the hygroscopicity of the crystals are much lower than that of conventional polymorphic crystals, providing excellent stability during storage. The present invention also relates to a method for preparing the I- and II-type crystals of L-?-glyceryl phosphoryl choline.

Abstract: Methods for recovery of recyclable water and/or fermentation co-products from thin stillage process streams. Microbial metabolites plant derivatives and/or plant extractives are removed from thin stillage after which water is recovered and recycled. Thin stillage is commingled with polar organic solvents or with oil to react microbial metabolites, plant derivatives and/or plant extractives. The reacted organic solvents are then separated from the processed thin stillage. Thin stillage may be commingled with an oil to re act with certain organic compounds, after which, the reacted oil is separated from the processed thin stillage is further extracted with one or more polar organic solvents. Alternatively, thin stillage may be first processed with one or more polar organic solvents, and then processed with an oil. Useful organic compounds may be recovered from the reacted oil and reacted organic solvents.

Abstract: The present invention relates to I- and II-type crystals of L-?-glyceryl phosphoryl choline, and to a method for preparing same. More particularly, the present invention relates to noble I- and II-type anhydride crystals of L-?-glyceryl phosphoryl choline, which have a higher purity than conventional liquid L-?-glyceryl phosphoryl choline, and one advantage of which is that formulations and dosages of pharmaceuticals are easily modified, and another advantage of which is that the hygroscopicity of the crystals are much lower than that of conventional polymorphic crystals, providing excellent stability during storage. The present invention also relates to a method for preparing the I- and II-type crystals of L-?-glyceryl phosphoryl choline.

Abstract: A process for the extraction of macromolecules from a biomass material comprising: a) contacting the biomass material with a solution comprising thin stillage to provide a slurry comprising undissolved solids, dissolved solids and suspended solids; and b) separating undissolved solids from the slurry to provide a solid fraction and a liquid fraction; and wherein the macromolecules are comprised in the dissolved solids.

Abstract: Mixtures of three types of linear, branched or cyclic phosphates are useful flame retardants, especially for thermoplastic resins or as functional additives in polymer matrices.

Abstract: One or more triorganophosphite components are separated from a crude phosphite mixture containing acidic hydrolysis products. The crude phosphite mixture is contacted with a basic additive to produce a second mixture comprising a first phase and a second phase. The first phase comprises the basic additive and one or more acidic hydrolysis products and the second phase comprises one or more triorganophosphite components.

Abstract: The present invention is directed to processes associated with the preparation of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)ethyl]phosphonic acid (perzinfotel).

Abstract: Provided are methods and compositions which are useful for separating, isolating, detecting, and quantifying compounds of interest which have been modified chemically, enzymatically or catalytically from other compounds which have not been so modified. The modifications may take the form of functional groups which are gained, lost or retained by the compounds of interest.

Abstract: A method of removing trace levels of arsenic-containing impurities from raw triethylphosphate (TEPO) is disclosed. The method uses adsorption, or adsorption followed by a flash distillation. The method comprises contacting raw triethylphosphate (TEPO) with an adsorbent which selectively adsorbs the arsenic-containing impurities in the raw triethylphosphate (TEPO). The adsorbent is a base promoted alumina containing adsorbent represented by a formula: ZxWy; where x is the weight percentage of Z in the adsorbent ranging from 30% to 99.999%; y is the weight percentage of W in the adsorbent, and x+y=100%; Z is selected from the group consisting of alumina (Al2O3), magnesium-alumina based layered double hydroxide (MgO—Al2O3), alumina-zeolite, and mixtures thereof; and W is selected from the group consisting of at least one basic metal oxide, at least one basic metal carbonate, and mixtures thereof.

Abstract: A process for producing a purified O—(2,6-dichloro-4-methylphenyl)—O,O-dimethyl phosphorothioate, the process comprising: the first step of bringing a crude O—(2,6-dichloro-4-methylphenyl)—O,O-dimethyl phosphorothioate into contact with an acid; and the second step of recovering the purified O—(2,6-dichloro-4-methylphenyl)—O,O-dimethyl phosphorothioate from the mixture obtained in the first step.

Abstract: Methods for recovery of recyclable water and/or fermentation co-products from thin stillage process streams. Microbial metabolites and/or plant derivatives and/or plant extractives are removed from thin stillage after which, recyclable water is recovered from the processed thin stillage. Thin stillage is commingled with one or more polar organic solvents to react microbial metabolites and/or plant derivatives and/or plant extractives with the organic solvents. The reacted organic solvents are then separated from the processed thin stillage. Thin stillage may be commingled with an oil to re act with certain organic compounds, after which, the reacted oil is separated from the processed thin stillage is further extracted with one or more polar organic solvents. Alternatively, thin stillage may be first processed with one or more polar organic solvents, and then processed with an oil. Useful organic compounds may recovered from the reacted oil and from the reacted organic solvents.

Abstract: Disclosed are: a sense-improving agent which comprises, as an active ingredient, a phospholipid or a sphingosine-containing phospholipid and/or a derivative thereof, particularly a sphingomyelin, and which has an effect of improving the dulling of senses at a periphery when ingested orally or directly applied to the skin; and a sense-improving food, beverage, feed or cosmetic comprising the sense-improving agent. The phospholipid to be used may be a chemically synthesized phospholipid or a naturally occurring phospholipid, preferably a phospholipid derived from an edible material such as soybean and egg yolk, particularly preferably a phospholipid derived from milk.

Abstract: Phosphate esters useful for gelling hydrocarbons in combination with a metal source are disclosed along with methods of preparation of the phosphate esters. Fouling in oil refinery towers has been attributed due to distillation of impurities present in phosphate esters used to gel hydrocarbons for oil well fracturing. The improved method of preparation of the phosphate ester results in a product that substantially reduces or eliminates volatile phosphorus, which is phosphorus impurities that distill up to 250° C., and increases the high temperature viscosity of the hydrocarbon gels formed using the phosphate esters.

Abstract: Provided are processes for the purification of a pure rosuvastatin intermediate by thin film evaporation and chemical method, and conversion of the intermediate to rosuvastatin or salts thereof.

Abstract: The present invention relates to a sterile, stable dosage forms suitable for reconstitution and parenteral administration to a patient, said dosage form comprising an amorphous aminoalkyl dihydrogen phosphorothioate, and of amifostine in particular. The invention further relates to a method of preparing such a dosage form, which typically exhibits enhanced thermal stability as compared to existing vacuum dried amorphous amifostine.

Abstract: One or more triorganophosphite components are separated from a crude phosphite mixture containing acidic hydrolysis products. The crude phosphite mixture is contacted with a basic additive to produce a second mixture comprising a first phase and a second phase. The first phase comprises the basic additive and acidic hydrolysis products. The second phase comprises one or more triorganophosphite components.

Abstract: Methods are disclosed for extracting and separating polar lipids, including phospholipids, from materials containing oil, polar lipid, protein, ash, and/or carbohydrate, such as egg yolks and other phospholipid-containing materials. In particular, methods for extracting phospholipids from phospholipid-containing materials through the use of an aliphatic alcohol and control of temperature are disclosed. Using these methods, phospholipids in the aqueous liquid fraction will be efficiently separated and will precipitate readily, and can be subjected to separation for improved purity.

Abstract: Provided are processes for the purification of a pure rosuvastatin intermediate by thin film evaporation and chemical method, and conversion of the intermediate to rosuvastatin or salts thereof.

Abstract: The present invention relates to processes for the preparation of (?-aminoalkylamino)alkyl halides, their conversion to S-?-(?-aminoalkylamino)alkyl phosphothioates, and purification of the crystalline products of the reaction. The preparation process for the (?-aminoalkylamino)alkyl halides comprises contacting an appropriate alcohol with a brominating agent in the presence of a sulfone solvent under temperature and pressure conditions suitable to effect salt formation without subsequent premature precipitation. The process is especially useful for converting (?-aminoalkylamino)ethyl alcohol to amifostine.

Abstract: The invention relates to a process for immobilizing acidic or electrophilic compounds in a solution. The process is characterized in that it consists in bringing a crosslinked polyimine, which is insoluble in the medium and in which the imino groups are —NH-groups, into contact with said compounds and in then separating, by filtration, the modified polyimine obtained. The crosslinked polyimine comprises linear segments composed of —HN—R1—NH—R2—Ar—R3-units in which R1, R2 and R3 are identical or different alkylene or alkenylene groups and Ar represents an aromatic group. The process is of use for fixing undesirable compounds or for purifying acidic compounds.

Abstract: The invention provides a method for separating one or more triorganophosphite components from a crude phosphite mixture containing acidic hydrolysis products, the method comprising: contacting said crude phosphite mixture with a basic additive to produce a second mixture comprising a first phase and a second phase, wherein said first phase comprises the basic additive and one or more components independently selected from the group consisting of (R2O)(R3O)POH, (R1O)(HO)PO(H) and H3PO3, wherein R1, R2 and R3 are independently selected from the group consisting of C1 to C18 alkyl, C6 to C18 aryl and hydroxyaryl, and C3 to C18 cycloalkyl and hydroxyalkyl radicals, and wherein R2 and R3 can optionally be connected to each other directly by a chemical bond or through an intermediate divalent group R9; and said second phase comprises one or more triorganophosphite components independently selected from the group consisting of (R4O)(R5O)P(OR6) and ((R7O)(R8O)PO)nA, wherein R4, R5, R6, R7 and R8 are independently sel

Abstract: Neopentyl glycol bis(diphenyl phosphate) liquid compositions are described that comprise from about 75% to about 90%, by weight, of neopentyl glycol bis(diphenyl phosphate), less than about 5% by weight of cyclic product, less than about 8% by weight of triphenyl phosphate, and with a P3 content of no less than about 1%, by weight. These compositions are made by continuously adding neopentyl glycol to a diaryl chlorophosphate mixture at elevated temperature, under vacuum, and in the presence of a catalyst.

Abstract: Acids can be removed from aprotic organic liquids by bringing the liquids into contact with polyalkyleneimines that have been applied to a support. Polyethyleneimine that has been applied to amorphous silicon dioxide is particularly suitable for this method. The method can be used, for example, to eliminate acidic components from fluorinated esters.

Abstract: The present invention relates to a sterile, stable dosage forms suitable for reconstitution and parenteral administration to a patient, said dosage form comprising an amorphous aminoalkyl dihydrogen phosphorothioate, and of amifostine in particular. The invention further relates to a method of preparing such a dosage form, which typically exhibits enhanced thermal stability as compared to existing vacuum dried amorphous amifostine.

Abstract: Acids can be removed from aprotic organic liquids by bringing the liquids into contact with polyalkyleneimines that have been applied to a support. Polyethyleneimine that has been applied to amorphous silicon dioxide is particularly suitable for this method. The method can be used, for example, to eliminate acidic components from fluorinated esters.

Abstract: The invention relates to a method of purifying an O,O-dialkyl S-[2-(alkylthio)alkyl] phosphorodithioate by purging a sample containing a volatile and the O,O-dialkyl S-[2-(alkylthio)alkyl] phosphorodithioate with a gas.

Abstract: A crude phosphate ester product can be purified by first washing it with chelating agent composition (such as a dilute acidic solution) and then, preferably, water, drying the resulting product, and then treating the resulting product with an acid scavenger, as exemplified by an epoxy-containing compound, such as 3,4-epoxy cyclohexyl methyl-3,4-epoxy cyclohexyl carboxylate.

Abstract: A process for the separation and recycling of catalyst components from a chemical reaction mixture is disclosed. The process entails at least one extraction step.

Abstract: A polyphosphate ester composition consisting essentially of an effective amount of a cycloaliphatic epoxy composition for reduction of the total acid number of the composition. The phosphate ester is of the formula: where R can be aryl or alkaryl, R′ can be arylene, arylene-alkylene-arylene, or alkylene, and n ranges from about 1 to about 5.

Abstract: A method of purifying an organic phosphoric ester characterized by treating a crude organic phosphoric ester with an epoxy compound and treating the treated organic phosphoric ester with an alkaline aqueous solution to purify it. The purification method is effective in stably obtaining an organic phosphoric ester reduced in acid value and excellent in heat resistance, hydrolytic resistance, and storage stability, regardless of the kind or amount of the organic phosphoric ester, the treating conditions, etc.

Abstract: A process for the separation and recycling of catalyst components from a chemical reaction mixture is disclosed. The process entails at least one extraction step.

Abstract: A process for the removal and recovery of quaternary salt (A) and base (D) from a reaction mixture is disclosed. The reaction mixture resulting from oxidative direct carbonylation contains in addition to (A) and (D), at least one hydroxyaromatic compound (B) and at least one reaction product (C) and optionally a solvent, and the process entails a) adding acid to the reaction mixture to cause conversion of (D) into a hydroxyaromatic compound (B2) b) separating the reaction mixture into b1.) that contains (C) and optionally (B) and/or (B2) and b2.) that contains (A) and optionally (B) and/or (B2), and c) reacting b1.) with a base (E) to re-form (D).

Abstract: The present invention relates to a sterile, stable dosage forms suitable for reconstitution and parenteral administration to a patient, said dosage form comprising an amorphous aminoalkyl dihydrogen phosphorothioate, and of amifostine in particular. The invention further relates to a method of preparing such a dosage form, which typically exhibits enhanced thermal stability as compared to existing vacuum dried amorphous amifostine.

Abstract: The present invention relates to a sterile, stable dosage forms suitable for reconstitution and parenteral administration to a patient, said dosage form comprising an amorphous aminoalkyl dihydrogen phosphorothioate, and of amifostine in particular. The invention further relates to a method of preparing such a dosage form, which typically exhibits enhanced thermal stability as compared to existing vacuum dried amorphous amifostine.

Abstract: A novel process is described for preparing phosphonites or phosphinites by reacting a product of a Friedel-Crafts reaction with alcohols or phenols and separating off the byproducts formed. The novelty is the aftertreatment with a protic compound, or with an oxide, hydroxide, (hydrogen)carbonate resp. (hydrogen)phosphate of a metal or with a nitrogen containing compound (as defined in claim 1), or with any combination of one or more substances of the above mentioned compound classes. Products having a low halide and aluminum content are obtained which are distinguished by an improved clear solubility and an improved action as stabilizer for polymeric materials.

Abstract: The geometric isomers of olefins and olefinic compounds are separated by means of liquid chromatography using a stationary phase comprising an organosilane with a pendant aliphatic functional group such as C18 and a mobile phase which includes an additive comprising alkanes and alkenes.

Abstract: The present invention relates to a sterile, stable dosage forms suitable for reconstitution and parenteral administration to a patient, said dosage form comprising an amorphous aminoalkyl dihydrogen phosphorothioate, and of amifostine in particular. The invention further relates to a method of preparing such a dosage form, which typically exhibits enhanced thermal stability as compared to existing vacuum dried amorphous amifostine.

Abstract: The present invention provides methods of administering aminoalkyl phosphorothioate and/or aminoalkyl thiol compounds to patients in a manner that significantly reduces or decreases the adverse or undesirable side-effects of the compounds as compared with conventional intravenous administration.

Abstract: The present invention provides methods of administering aminoalkyl phosphorothioate and/or aminoalkyl thiol compounds to patients in a manner that significantly reduces or decreases the adverse or undesirable side-effects of the compounds as compared with conventional intravenous administration.

Abstract: The present invention provides a method for making O,S-dimethyl phosphoramidothioate. In accordance with this process, O,O-dimethyl phosphoramidothioate is isomerized in the presence of dimethyl sulfate to form a reaction mixture; the reaction mixture is then passed through a wiped film evaporator at a temperature of from about 55.degree. C. to about 120.degree. C. and a pressure of from about 3 to about 10 mm Hg, with the distillate containing O,S-dimethyl phosphoramidothioate, unreacted O,O-dimethyl phosphoramidothioate and by-products, and the residue containing O,S-dimethyl phosphoramidothioate in an amount greater than the amount of O,S-dimethyl phosphoramidothioate contained in the reaction mixture prior to distillation.

Abstract: A process for the preparation of C.sub.14 -C.sub.18 -alkylphosphocholines by reacting an n-alkanol with a chain length of C.sub.14 -C.sub.18 with phosphorus oxychloride in an inert solvent or also without solvent in the presence or absence of a basic substance in a single vessel process and subsequent reaction of the reaction product in an inert solvent with a choline salt in the presence of a basic substance to form phosphoric acid diester chloride, subsequent hydrolysis and isolation of alkylphosphocholine as well as optionally purification using a mixed-bed ion exchanger or in successive steps with an acid ion exchanger and a basic ion exchanger.

Abstract: A process for the preparation of C.sub.14 -C.sub.18 -alkylphosphocholines by reacting an n-alkanol with a chain length of C.sub.14 -C.sub.18 with phosphorus oxychloride in an inert solvent or also without solvent in the presence or absence of a basic substance in a single vessel process and subsequent reaction of the reaction product in an inert solvent with a choline salt in the presence of a basic substance to form phosphoric acid diester chloride, subsequent hydrolysis and isolation of alkylphosphocholine as well as optionally purification using a mixed-bed ion exchanger or in successive steps with an acid ion exchanger and a basic ion exchanger.

Abstract: The invention is directed to a process for producing a stable, low odor S,S,S-tributylphosphorotrithioate having a level of dibutyl disulfide of 0.3% by weight or less. The process broadly includes the steps ofa) reacting S,S,S-tributylphosphorotrithioite with an oxidizing agent to produce a crude S,S,S-tributylphosphorotrithioate,b) treating the crude product with sodium bisulfite to decompose any excess oxidizing agent,c) adding a caustic solution having a caustic concentration of from 25 to 50% by weight directly to the reaction mixture of step b), the addition of said caustic solution being stopped once the total caustic concentration is less than 10% by weight and once the pH is constant, andd) phase separating S,S,S-tributylphosphorotrithioate from the mixture of step c).

Abstract: A method for purifying O,S-dimethyl N-acetyphosphoramidothioate, which is characterized by subjecting a crude crystal of O,S-dimethyl N-acetylphosphoramidothioate to recrystallization by using a two-phase solvent system comprising water and an organic which is an aromatic hydrocarbon, an aliphatic carboxylic acid ester or aliphatic ketone, wherein the amount of water is 0.1 to 2 parts by weight and the amount of the organic solvent is 1 to 20 parts by weight to 1 part by weight of the crude O,S-dimethyl N-acetylphosphoramidothioate.