Abstract: Novel phosphate-bearing prodrugs of sulfonyl hydrazines have the formula presented below. Pharmaceutical compositions and uses thereof in the treatment of cancer are claimed. The aforementioned prodrugs include enantiomers, stereoisomers and tautomers thereof, as well as pharmaceutically acceptable salts or solvates and metabolites from all stages. The aforementioned prodrugs are preferentially activated in hypoxic tumors and can be given either alone, or in combination with other anticancer agents or with phototheraphy or radiotherapy. where R is C1-C10 alkyl or haloalkyl; R? and R? are each independently C1-C10 alkyl; R1 is CH3; and X is O; or a pharmaceutically acceptable salt, solvate, polymorph or metabolite thereof.

Abstract: This invention relates to a new class of phosphoryl hydrazine compounds which are useful as insecticides, acaricides, anthelmintics, and nematocides, compositions containing the compounds, and methods for their use. This invention also relates to methods to produce such compounds.

Abstract: Compounds of formula (I) ##STR1## wherein each X separately is halogeno, hydroxy, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, nitro or an unsubstituted or substituted amino group NRR' in which R and R' are each separately selected from hydrogen, C.sub.1-4 alkyl groups and C.sub.2-4 halogenated alkyl groups;wherein Y is halogeno, hydroxy, C.sub.1-4 alkoxy or an unsubstituted or substituted amino group NRR' in which R and R' are as defined above;wherein n represents 0, 1, 2 or 3 and n' represents 1, 2, 3 or 4;wherein R.sup.1 and R.sup.2 each separately represent hydrogen, halogeno, phenyl or a C.sub.1-4 alkyl group, or together represent a group .dbd.NOR" in which R" is hydrogen or is a group ZC(O)-- or (ZO).sub.2 P(O)-- where Z is a C.sub.1-4 alkyl group; andwherein R.sup.3 and R.sup.4 each separately represent hydrogen, acetyl, phenyl, 2,2,2-trichloro-1-hydroxyethyl or a C.sub.1-4 alkyl group, or together represent a group .dbd.CHR"' in which R"' is a C.sub.1-4 alkyl, C.sub.

Abstract: New phosphazene derivatives, fully substituted by aromatic groups and perfluoropolyethereal chains, are utilized as stabilizers for oils and greases based on perfluoropoyethers. Such derivatives inhibit the degradation process affecting the perfluoropolyethereal chains when these are subjected to high temperatures in an oxidizing atmosphere and in the presence of metals, such as for example aluminium, titanium, vanadium and their alloys, or steels.

Abstract: This invention relates to bisphosphoryl hydrazine compounds and to compositions thereof which are useful as pesticides. The compounds of this invention are effective against soil insects, especially the corn rootworm.

Abstract: Compounds having the formula: ##STR1## wherein R is C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkyl, hydrogen, halogen, or C.sub.1 -C.sub.4 alkylthio; R.sup.1 is phenyl, phenoxy, or benzyl, the phenyl ring of each substituent being optionally substituted with one or more of halogen, nitro, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 haloalkyl or di(C.sub.1 -C.sub.4 alkyl)amino; and R.sup.2 is branched or straight-chained, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, C.sub.3 -C.sub.6 cycloalkoxy, C.sub.1 -C.sub.6 haloalkyl, alkoxyalkyl, C.sub.1 -C.sub.6 alkenyl, C.sub.1 -C.sub.6 alkylthio, (C.sub.1 -C.sub.6 alkoxy)carbonyl, C.sub.1 -C.sub.6 alkylamino, C.sub.1 -C.sub.6 haloalkoxy, or C.sub.3 -C.sub.6 cycloalkyl. These compounds are effective for controlling mites.

Abstract: This invention relates to bisphosphoryl hydrazine compounds and to compositions thereof which are useful as pesticides. The compounds of this invention are effective against soil insects, especially the corn rootworm.

Abstract: This invention relates to bisphosphoryl hydrazine compounds and to compositions thereof which are useful as pesticides. The compounds of this invention are effective against soil insects, especially the corn rootworm.

Abstract: Small peptidic compounds containing a small and branched chained amino acid residue, pharmaceutical compositions containing at least one such compound active against glaucoma and intraocular hypertension and a method for treating glaucoma and intraocular hypertension.

Abstract: This invention relates to bisphosphoryl hydrazine compounds and to compositions thereof which are useful as pesticides. The compounds of this invention are effective against soil insects, especially the corn rootworm.

Abstract: Novel phosphorus containing compounds are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful in preventing the intestinal absorption of cholesterol and thus are useful in the treatment of hypercholesterolemia and atherosclerosis.

Abstract: Compositions comprising an organic material liable to oxidative, thermal and/or actinic degradation and at least one compound of the formula I ##STR1## are described in which n is 1-6, R, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are preferably hydrogen and A is a monovalent radical or polyvalent linking moiety.Some of the compounds of the formula I are novel. They are particularly suitable for the stabilization of lubricating oils, metal processing fluids and hydraulic fluids, and of thermoplastics and elastomers.

Abstract: Novel carboxamide compounds represented by the general formula (I) possess excellent activities for lowering lipids and thus they are useful as agents for treating and preventing various diseases (hyperlipidemia) such as hypercholesterolemia, hypertriglyceridemia, hyperphospholipidemia, hyperlipacidemia, and the like.

Abstract: The present invention comprises reaction products resulting from the reaction of hydrazido-substituted or certain amino-substituted polymer stabilizers and cyclic dianhydrides, as well as the use of such products. The polymer stabilizers of the invention are useful for protecting a large variety of synthetic polymeric organic materials from the degradative effects of heat, light and oxygen. Some of the modifiers are flame retardants and many are metal deactivators in addition to their primary activity.

Abstract: There are described compounds of formula I,ZCHRCON(--N.dbd.CR.sub.4 R.sub.5)CHR.sub.6 (CH.sub.2).sub.n COY Iwhere the substituents are defined in the disclosure.There are also described methods for making the compounds, formulations containing them and their use, e.g. as antihypertensives.

Abstract: Novel acylated hydrazinomethylphosphonic acids, hydrazinomethylphosphonates, hydrazinomethylphosphinic acids, hydrazinomethylphosphinates or hydrazinomethylphosphine oxides of formula I below are able as "antidotes" or "safeners" to protect cultivated plants from the phytotoxic action of herbicides. Suitable crops are preferably maize, sorghum, cereals, rice and soybeans and the herbicides employed are in particular chloroacetanilides.

Abstract: Novel acylated hydrazinomethylphosphonic acids, hydrazinomethylphosphonates, hydrazinomethylphosphinic acids, hydrazinomethylphosphinates or hydrazinomethylphosphine oxides of formula I below are able as "antidotes" or "safeners" to protect cultivated plants from the phytotoxic action of herbicides. Suitable crops are preferably maize, sorghum, cereals, rice and soybeans and the herbicides employed are in particular chloroacetanilides.The acylated hydrazinomethylphosphonates, hydrazinomethylphosphinates or hydrazinomethylphosphine oxides have the formula I ##STR1## wherein R.sub.1 and R.sub.2 are each independently hydroxy, alkyl, aryl, phenylalkyl, alkoxy, alkenyloxy, alkynyloxy, aryl or phenylalkoxy, the radicals of which may be substituted,R.sub.3 is a halogenated alkanoyl or alkenoyl radicalR.sub.

Abstract: The invention provides polyurethanes and polyisocyanurate having incorporated therein a flame retardant amount of a salt formed by reaction between dimethyl methyl phosphonate, monomethyl methyl phosphonate or methyl phosphonic acid, and a compound of the general formula (I). ##STR1## in which X is O, S or NH, R.sup.1 is H, alkyl with 1 to 4 carbon atoms, alkenyl of up to 4 carbon atoms, CN, CONH.sub.2 or NH.sub.2, R.sup.2 is H, alkyl with 1 to 4 carbon atoms or alkenyl of up to 4 carbon atoms or R.sup.1 and R.sup.2 together with the nitrogen atom to which they are attached form a heterocyclic ring of up to 6 carbon atoms which may optionally contain another hetero atom and R is H, an alkyl group with 1 to 8 carbon atoms, an aryl group with 6 to 10 carbon atoms, a cycloalkyl group with 5 to 12 carbon atoms or a heterocyclic group with up to 9 ring carbon atoms, or, together with R.sup.1 forms an alkylene chain of 3 to 10 carbon atoms, or R is a group NHR.sup.3 wherein R.sup.