Nitrogen Bonded Directly To Phosphorus Patents (Class 558/157)
  • Patent number: 10655005
    Abstract: An epoxy resin composition comprising an epoxy resin (A), a curing agent (B) and a phosphorous-containing compound (C) indicated by the following general formula (1) and also, if necessary, a flame retardant (D), and a laminated plate comprising said resin composition; wherein m indicates an integer from 2 to 10, R1 to R4 each independently indicate a hydrogen atom, an alkyl group or an aryl group, R5 indicates a hydrocarbon group that may contain an oxygen atom, a sulfur atom or a nitrogen atom, X indicates an oxygen atom or a sulfur atom, Y indicates an oxygen atom, a sulfur atom or —NR6—, and R6 indicates a hydrogen atom, an alkyl group or an aryl group.
    Type: Grant
    Filed: March 22, 2016
    Date of Patent: May 19, 2020
    Assignee: ADEKA CORPORATION
    Inventors: Takeshi Endo, Kozo Matsumoto, Ken-ichi Tamaso, Chihiro Asakura, Ryo Ogawa
  • Patent number: 8999323
    Abstract: The present invention relates to a polymerization-curable composition for the preparation of biodegradable, biocompatible, cross-linked polymers on the basis of polyvinyl alcohol comprising: 5 to 100% by weight of (a) vinyl ester monomer(s) of one of the general formulas (I) to (III): wherein X is oxygen, sulfur, nitrogen, or phosphorus; n is 1 to 1000, at least 20% of the n being ?2; the R1 are selected from hydrogen; straight, branched or cyclic, saturated or unsaturated, n-valent hydrocarbon groups having 1 to 30 carbon atoms, which optionally have heteroatoms and are optionally substituted with one or more substituents selected from —OH, —COON, —CN, —CHO, and ?O, and n-valent radicals of biodegradable, biocompatible oligomers and polymers; m is an integer from 1 to 5; the R2 are selected from hydrogen, —OH, ?O, and the options listed for R1; and the R3 are selected from hydrogen, —OH, and the options listed for R1; 0 to 50% by weight of ethylenically unsaturated co-monomers; 0 to 10% by weight of (a)
    Type: Grant
    Filed: November 21, 2008
    Date of Patent: April 7, 2015
    Assignee: Technische Universität Wien
    Inventors: Robert Liska, Jürgen Stampfl, Franz Varga, Heinrich Gruber, Stefan Baudis, Christian Heller, Monika Schuster, Helga Bergmeister, Günter Weigel, Claudia Dworak
  • Patent number: 9000077
    Abstract: A phosphazene compound having a vinyl group is manufactured by a reaction between a vinyl compound and a phosphazene compound having a hydroxyl group and added to a resin composition for manufacturing a prepreg or a resin film so as to be applicable to copper-clad laminates and printed circuit boards to thereby achieve satisfactory circuit laminate properties, namely low coefficient of thermal expansion, low dielectric properties, heat resistant, fire resistant, and halogen-free.
    Type: Grant
    Filed: June 19, 2013
    Date of Patent: April 7, 2015
    Assignee: Elite Material Co., Ltd.
    Inventor: Chen-Yu Hsieh
  • Publication number: 20140323624
    Abstract: A phosphazene compound having a vinyl group is manufactured by a reaction between a vinyl compound and a phosphazene compound having a hydroxyl group and added to a resin composition for manufacturing a prepreg or a resin film so as to be applicable to copper-clad laminates and printed circuit boards to thereby achieve satisfactory circuit laminate properties, namely low coefficient of thermal expansion, low dielectric properties, heat resistant, fire resistant, and halogen-free.
    Type: Application
    Filed: June 19, 2013
    Publication date: October 30, 2014
    Inventor: CHEN-YU HSIEH
  • Patent number: 8772268
    Abstract: Bisphosphonamidate prodrugs of therapeutic bisphosphonate compounds and uses thereof to treat diseases are described.
    Type: Grant
    Filed: April 27, 2011
    Date of Patent: July 8, 2014
    Assignee: The Johns Hopkins University
    Inventors: Caren Laura Freel Meyers, Marie Webster
  • Patent number: 8541612
    Abstract: The present invention relates to unsaturated diphosphine monoxides, to a process for preparation thereof and to the use thereof as flame retardants.
    Type: Grant
    Filed: March 23, 2009
    Date of Patent: September 24, 2013
    Assignee: BASF SE
    Inventors: Alexander Tishkov, Klemens Massonne
  • Publication number: 20130123402
    Abstract: Predominately amino terminated phosphonamide oligomers and their use as flame retardant additives in polyamides and copolyamides without detracting from melt processability are described herein. Other important properties such as strength, modulus, dyeing and thermal stability are maintained.
    Type: Application
    Filed: November 12, 2012
    Publication date: May 16, 2013
    Applicant: FRX POLYMERS, INC.
    Inventor: FRX Polymers, Inc.
  • Publication number: 20130090311
    Abstract: Bisphosphonamidate prodrugs of therapeutic bisphosphonate compounds and uses thereof to treat diseases are described.
    Type: Application
    Filed: April 27, 2011
    Publication date: April 11, 2013
    Applicant: The Johns Hopkins University
    Inventors: Caren Laura Freel Meyers, Marie Webster
  • Patent number: 8193384
    Abstract: The synthesis and biochemical utility of modified oligonucleotides containing diphosphodiester internucleotide linkages. The synthesis of these compounds was carried out using diphosphitylating reagents. Oligonucleotides containing diphosphate diester bridges wherein said oligonucleotides are synthesized via a solid-phase synthesis strategy to form modified oligonucleotides. Diphosphitylating, triphosphitylating, tetraphosphitylating, ?-triphosphitylating, bifunctional diphosphitylating, bifunctional triphosphitylating, and bifunctional tetraphosphitylating reagents wherein, the phosphorus atoms are linked together through oxygen, sulfur, amino, or methylene groups and/or are substituted with chlorine, diisopropylamine and cyanoethoxy groups.
    Type: Grant
    Filed: January 10, 2008
    Date of Patent: June 5, 2012
    Assignee: Board of Governors for Higher Education, State of Rhode Island and Providence Plantation
    Inventors: Keykavous Parang, Yousef Ahamdibeni
  • Publication number: 20120119172
    Abstract: The invention relates to the use of amino terminated phosphonamides and their oligomers, as flame retardant additives for a variety of polymers to impart flame retardancy while maintaining or improving processing characteristics and other important properties.
    Type: Application
    Filed: November 11, 2011
    Publication date: May 17, 2012
    Applicant: FRX POLYMERS, INC.
    Inventors: Dieter FREITAG, Marc-Andre LEBEL, Lawino KAGUMBA, Marc E. LEBEL, Peter S. SCHULER
  • Publication number: 20120053356
    Abstract: This invention describes the synthesis and use of novel energetic poly(phosphazene) materials suitable for binding high explosives. These materials may also be used as explosives in their own right. The materials possess high energy density and are highly amenable to chemical modification thereby allowing for modification to the physical properties of the material. In particular the tacky and rubbery nature of these materials makes them ideal for use as binder and co-binder materials.
    Type: Application
    Filed: November 9, 2011
    Publication date: March 1, 2012
    Applicant: The Secretary of State for Defense
    Inventors: Peter GOLDING, Stephen John Trussell, Martin Eamon Cololough, Javid Hamid
  • Patent number: 8093231
    Abstract: Sulfonylethyl and thioethyl phosphorodiamidates, their preparation and intermediates in their preparation, formulations containing them, and their pharmaceutical use. The compounds are useful for treating cancer, alone and in combination with other anticancer therapies.
    Type: Grant
    Filed: July 17, 2007
    Date of Patent: January 10, 2012
    Assignee: Telik, Inc.
    Inventors: David R. Allen, Wenli Ma, Brian T. Peterson, Louise Robinson, Steven R. Schow, Songyuan Shi, Reyna J. Simon, Kevin T. Weber, Michael M. Wick
  • Publication number: 20110245367
    Abstract: Described herein is a degradable linking agent of formula Photo1-LG-Photo2, wherein Photo1 and Photo2 independently represent at least one photoreactive group and LG represents a linking group comprising one or more silicon atoms or one or more phosphorous atoms. The degradable linking agent includes a covalent linkage between at least one photoreactive group and the linking group, wherein the covalent linkage between at least one photoreactive group and the linking group is interrupted by at least one heteroatom. A method for coating a support surface with the degradable linking agent, coated support surfaces and medical devices are also described.
    Type: Application
    Filed: March 29, 2011
    Publication date: October 6, 2011
    Applicant: SurModics, Inc.
    Inventors: Aleksey V. Kurdyumov, Dale G. Swan
  • Patent number: 7767739
    Abstract: A phosphazene compound, which can effectively enhance flame retardancy without deteriorating mechanical properties of a resin molded product, and is also less likely to deteriorate thermal reliability and dielectric properties, is represented by the formula (1) shown below. n represents an integer of 3 to 15. wherein A represents a group selected from the group consisting of an alkoxy group, an aryloxy group and a group having a cyanato group, and at least one is a group having a cyanato group, and an example of A is a cyanatophenyl-substituted phenyloxy group represented by the formula (4) shown below, and Y in the formula (4) represents O, S, SO2, CH2, CHCH3, C(CH3)2, C(CF3)2, C(CH3)CH2CH3 or CO.
    Type: Grant
    Filed: January 9, 2007
    Date of Patent: August 3, 2010
    Assignee: Fushimi Pharmaceutical Co., Ltd.
    Inventors: Yuji Tada, Takashi Inoue
  • Publication number: 20090043032
    Abstract: Disclosed is a reactive flame retardant which provides a resin with excellent flame retardance even when it is added in a small amount while being prevented from bleedout. Also disclosed is a flame-retardant resin processed article obtained by using such a reactive flame retardant. An organophosphorus compound represented by the general formula (I) below, wherein at least one or more of X1-X3 represent a group containing phosphorus and having a terminal unsaturated group, is used as a reactive flame retardant which is reactive with resins. A flame-retardant resin processed article can be obtained by solidifying the resin composition containing the organophosphorus compound and then reacting it through heating or application of radiation.
    Type: Application
    Filed: February 16, 2006
    Publication date: February 12, 2009
    Applicant: Fuji Electric Holdings Co., Ltd.
    Inventors: Toshiyuki Kanno, Yoshinobu Sugata, Hironori Yanase, Kiyotaka Shigehara
  • Patent number: 7262182
    Abstract: Sulfonylethyl and thioethyl phosphorodiamidates, their preparation and intermediates in their preparation, formulations containing them, and their pharmaceutical use. The compounds are useful for treating cancer, alone and in combination with other anticancer therapies.
    Type: Grant
    Filed: May 20, 2005
    Date of Patent: August 28, 2007
    Assignee: Telik, Inc.
    Inventors: Louise Robinson, Steven R. Schow, Songyuan Shi
  • Patent number: 6787528
    Abstract: The compounds of formula (I) are hydrophilic aryl phosphate, thiophosphate, and aminophosphate intestinal apical membrane Na-mediated phosphate co-transportation inhibitors. The compounds can be administered orally, where they act to inhibit Na-dependent phosphate uptake in the intestines, or internally, where they interact with the phosphate control functions of the kidneys and parathyroid. They are therefore useful for inhibiting sodium-mediated phosphate uptake, reducing serum PTH, calcium, calcitriol, and phosphate, and treating renal disease in an animal, including a human.
    Type: Grant
    Filed: January 7, 2002
    Date of Patent: September 7, 2004
    Assignee: Board of Regents, The University of Texas System
    Inventor: Brian E. Peerce
  • Publication number: 20040127734
    Abstract: An improved phenoxyphosphazene compound is produced by treating a phenoxyphosphazene compound with (a) at least one adsorbent selected from activated carbon, silica gel, activated alumina, activated clay, synthetic zeolite and macromolecular adsorbents, (b) at least one reagent selected from metal hydrides, hydrazine, hypochlorites, thiosulfates, dialkyl sulfuric acids, ortho esters, diazoalkanes, lactones, alkanesultones, epoxy compounds and hydrogen peroxide, or (c) both the adsorbent and reagent, thereby reducing the acid value of said phosphazene compound to lower than 0.025 mgKOH/g.
    Type: Application
    Filed: December 23, 2003
    Publication date: July 1, 2004
    Inventors: Shinji Nakano, Yuji Tada, Tadao Yabuhara, Takashi Kameshima, Yoichi Nishioka, Hiroyuki Takase
  • Publication number: 20030220515
    Abstract: This invention has an object of providing a flame retardant which advantageously has a high melting point and a low volatility and is unlikely to depress the inherent properties of resins. The flame retardant of the invention is a phosphazene compound crosslinked with a crosslinking group such as phenylene group, each of the crosslinking groups being interposed between the two oxygen groups left after the elimination of phenyl groups from the phosphazene compound, the amount of the phenyl groups in the crosslinked compound being 50 to 99.9% based on the total number of the phenyl groups in the phosphazene compound. The invention also provides a resin composition containing the flame retardant, and a molded article of the resin.
    Type: Application
    Filed: May 21, 2003
    Publication date: November 27, 2003
    Applicant: OTSUKA CHEMICAL CO., LTD.
    Inventors: Nakacho Yoshifumi, Yabuhara Tadao, Tada Yuji, Nishioka Yoichi
  • Publication number: 20030195372
    Abstract: Disclosed herein are processes for hydrocyanation and isomerization of olefins by using at least one multidentate phosphonite ligands, including organometallic phosphonite ligands with a Group VIII metal or Group VIII metal compound, and optionally, a Lewis acid promoter.
    Type: Application
    Filed: June 4, 2003
    Publication date: October 16, 2003
    Inventors: Christian P. Lenges, Helen S. M. Lu, Joachim C. Ritter
  • Publication number: 20030162753
    Abstract: The compounds of formula (I) are hydrophilic aryl phosphate, thiophosphate, and aminophosphate intestinal apical membrane Na-mediated phosphate co-transportation inhibitors. The compounds can be administered orally, where they act to inhibit Na-dependent phosphate uptake in the intestines, or internally, where they interact with the phosphate control functions of the kidneys and parathyroid. They are useful for inhibiting sodium-mediated phosphate uptake, reducing serum PTH, calcium, calcitriol, and phosphate, and treating renal disease in an animal, including a human.
    Type: Application
    Filed: November 12, 2002
    Publication date: August 28, 2003
    Inventor: Brian E. Peerce
  • Patent number: 6596893
    Abstract: This invention has an object of providing a flame retardant which advantageously has a high melting point and a low volatility and is unlikely to depress the inherent properties of resins. The flame retardant of the invention is a phosphazene compound crosslinked with a crosslinking group such as phenylene group, each of the crosslinking groups being interposed between the two oxygen groups left after the elimination of phenyl groups from the phosphazene compound, the amount of the phenyl groups in the crosslinked compound being 50 to 99.9% based on the total number of the phenyl groups in the phosphazene compound. The invention also provides a resin composition containing the flame retardant, and a molded article of the resin.
    Type: Grant
    Filed: August 12, 1999
    Date of Patent: July 22, 2003
    Assignee: Otsuka Chemical Co., Ltd.
    Inventors: Yoshifumi Nakacho, Tadao Yabuhara, Yuji Tada, Yoichi Nishioka
  • Publication number: 20030109736
    Abstract: The phosphorus-containing compound of the present invention is represented by the following formula (I), (II) or (III): 1
    Type: Application
    Filed: December 26, 2001
    Publication date: June 12, 2003
    Inventors: Yoko Onchi, Ikuo Takahashi
  • Publication number: 20030092802
    Abstract: This invention has an object of providing a flame retardant which advantageously has a high melting point and a low volatility and is unlikely to depress the inherent properties of resins. The flame retardant of the invention is a phosphazene compound crosslinked with a crosslinking group such as phenylene group, each of the crosslinking groups being interposed between the two oxygen groups left after the elimination of phenyl groups from the phosphazene compound, the amount of the phenyl groups in the crosslinked compound being 50 to 99.9% based on the total number of the phenyl groups in the phosphazene compound. The invention also provides a resin composition containing the flame retardant, and a molded article of the resin.
    Type: Application
    Filed: August 12, 1999
    Publication date: May 15, 2003
    Inventors: YOSHIFUMI NAKACHO, TADAO YABUHARA, YUJI TADA, YOICHI NISHIOKA
  • Publication number: 20020133036
    Abstract: The compounds of formula (I) are hydrophilic aryl phosphate, thiophosphate, and aminophosphate intestinal apical membrane Na-mediated phosphate co-transportation inhibitors. The compounds can be administered orally, where they act to inhibit Na-dependent phosphate uptake in the intestines, or internally, where they interact with the phosphate control functions of the kidneys and parathyroid. They are therefore useful for inhibiting sodium-mediated phosphate uptake, reducing serum PTH, calcium, calcitriol, and phosphate, and treating renal disease in an animal, including a human.
    Type: Application
    Filed: January 7, 2002
    Publication date: September 19, 2002
    Inventor: Brian E. Peerce
  • Patent number: 6417383
    Abstract: The present invention relates to novel cyclotriphosphazene derivatives represented by Formula (1) and a preparation method thereof wherein HNA is an amino acid group selected from glycine group(—NHCH2COO−), aminomalonic acid group(—NHCH(COO−)2), aspartic acid group (—NHCH(CH2COO−)COO−) and glutamic acid group (—NHCH(CH2CH2COO−)COO−), m is a repeating unit of poly(alkoxyethyleneglycol) selected from 2, 7, 12 and 16, and n is an integer representing number of alkyl carbons and selected from 0, 1, and 3.
    Type: Grant
    Filed: July 5, 2001
    Date of Patent: July 9, 2002
    Assignee: Korea Institute of Science and Technology
    Inventors: Youn Soo Sohn, Soo-Chang Song, Sang Beom Lee
  • Publication number: 20020049314
    Abstract: The present invention provides novel compounds that function as immunological adjuvants when co-administered with antigens, including, antigens used as vaccines for any disease or condition amenable to vaccination. The invention also provides adjuvant formulations comprising the novel compounds of the invention and methods for immunizing humans and non-human animals.
    Type: Application
    Filed: July 30, 2001
    Publication date: April 25, 2002
    Inventors: Lynn D. Hawkins, Sally T. Ishizaka, Michael Lewis, Pamela McGuiness, Jeffrey Rose
  • Patent number: 6355823
    Abstract: The compounds of formula (I) are hydrophilic aryl phosphate, thiophosphate, and aminophosphate intestinal apical membrane Na-mediated phosphate co-transportation inhibitors. The compounds can be administered orally, where they act to inhibit Na-dependent phosphate uptake in the intestines, or internally, where they interact with the phosphate control functions of the kidneys and parathyroid. They are therefore useful for inhibiting sodium-mediated phosphate uptake, reducing serum PTH, calcium, calcitriol, and phosphate, and treating renal disease in an animal, including a human.
    Type: Grant
    Filed: September 20, 2000
    Date of Patent: March 12, 2002
    Assignee: Board of Regents, The University of Texas System
    Inventor: Brian E. Peerce
  • Patent number: 6348612
    Abstract: Novel chiral amidophosphine-phosphinite compounds, which are present in (R) and (S) form, of the general formula wherein R1 signifies alkyl, cycloalkyl or aralkyl, R2 signifies alkyl, cycloalkyl, aralkyl or aryl and R3 and R4 each independently signify alkyl, cycloalkyl, aralkyl, aryl or heteroaryl or R3 and R4 together with the respective phosphorus atom signify a 9-dibenzophospholyl, 9-phosphabicyclo[3.3.1]nonyl or 9-phosphabicyclo[4.2.1]nonyl group and * denotes a chiral center, are manufactured by reacting a compound of the general formula R1C(OH)—CONHR2 (III) with a disubstituted chlorophosphane of the general formula R3R4PCl (IV) in a solvent and in the presence of a base.
    Type: Grant
    Filed: March 5, 1998
    Date of Patent: February 19, 2002
    Assignee: Roche Vitamins Inc.
    Inventors: Wolfgang Burkart, Michelangelo Scalone, Rudolf Schmid
  • Patent number: 6277988
    Abstract: Sterically hindered phosphoramidates such as N,N′-bis[di-(2,6-xylenoxy)phosphinyl]piperazine are prepared by the reaction of a sterically hindered diaryl chlorophosphate, such as di-(2,6-xylyl) chlorophosphate, with a basic nitrogen compound containing at least two basic N—H groups, preferably a heterocyclic compound such as piperazine, in a predominantly liquid, solvent-free reaction mixture. The reaction may be conducted in the melt or in the presence of a non-solvent carrier, typically an aliphatic hydrocarbon. An excess of the basic nitrogen compound is employed as an acid acceptor.
    Type: Grant
    Filed: February 29, 2000
    Date of Patent: August 21, 2001
    Assignee: General Electric Company
    Inventors: John Robert Campbell, James Anthony Cella, Gregory Ronald Gillette, John Edward Kochanowski, Matthew Ladd Reitz
  • Patent number: 6265599
    Abstract: The present invention provides a process for preparing a mixture of amino-containing phosphazenes having the following general formula (I) by reacting a (NPCl2)n phosphazene mixture with NH3 and HOR in the presence of a tertiary amine catalyst: NnPn(NH2)x(OR)2n−x  (l) wherein n≧3, 1≦x<2n, and R is phenyl or C3-C6 alkyl. In addition to simultaneously carrying out amination and esterification, the process of the present invention also simultaneously performs a regeneration of the catalyst. Furthermore, the invented process is a water-free process without the problem of a large quantity of waste water. Ammonium chloride, a by-product of the invented process, can be recovered in a subsequent process.
    Type: Grant
    Filed: July 12, 2000
    Date of Patent: July 24, 2001
    Assignee: Chung-Shan Institute of Science & Technology
    Inventors: Ching-Yuan Lee, Yie-Shun Chiu
  • Patent number: 6093758
    Abstract: Incorporation of phosphate and phosphonate units into the side groups of aryloxyphosphazenes, at both the polymer and cyclic trimer levels, is disclosed. Phosphorylated cyclic trimers are utilized as flame-retardant additives to polystyrene.
    Type: Grant
    Filed: June 16, 1999
    Date of Patent: July 25, 2000
    Assignee: The Penn State Research Foundation
    Inventors: Harry R. Allcock, Jonathan R. Taylor
  • Patent number: 6008398
    Abstract: A phosphorus ester oligomer having the structure: wherein A can be the same or different in each monomeric unit and each is independently selected from the group consisting of oxygen, sulfur, lower alkyl, substituted or unsubstituted alkylamino, substituted or unsubstituted arylamino and aminoalkyl; B.sub.1 and B.sub.2 can be the same or different and each is independently selected from hydrogen, lower alkyl, a labeling group, a protecting group, a phosphoramidate or a phosphomonoester; R.sub.1 can be the same or different in each monomeric unit, and in at least one of the non-nucleotide monomeric units, R.sub.
    Type: Grant
    Filed: February 1, 1996
    Date of Patent: December 28, 1999
    Assignee: Genzyme Corporation
    Inventors: Robert Gerard Gentles, Alan F. Cook, Morris Jonathan Rudolph, Reza Fathi
  • Patent number: 5955453
    Abstract: Membrane-permeant phosphoinositides, including phosphatidylinositol phosphate esters, are described. A membrane-permeant phosphoinositide includes groups that neutralize the charges of the phosphate moieties of the phosphoinositide. A cell can be treated with the membrane-permeant phosphoinositide, which is then absorbed into the cell. The neutralizing groups can be removed intracellularly to afford the charged phosphoinositide.
    Type: Grant
    Filed: April 24, 1998
    Date of Patent: September 21, 1999
    Assignee: The Regents of the University of California
    Inventors: Roger Y. Tsien, Tao Jiang
  • Patent number: 5935947
    Abstract: There are described compounds of the formula I ##STR1## in which R.sup.1 is (C.sub.1 -C.sub.10)-alkyl, (C.sub.1 -C.sub.8)-alkanoyl, (C.sub.6 -C.sub.10)-aryl or Het, each of which can be substituted by halogen, --OH, --NH.sub.2, --NH--CO--R.sup.7, --O--CO--R.sup.7 and --N--(R.sup.8).sub.2 where R.sup.7 =(C.sub.1 -C.sub.6)-alkyl and R.sup.8, independently of one another, is hydrogen or (C.sub.1 -C.sub.2)-alkyl or in which R.sup.1 is the radical of the formula II ##STR2## in which n is an integer from 3 to 10, m is zero to 3, R.sup.6, independently of one another, is (C.sub.1 -C.sub.6)-alkyl which is optionally substituted by halogen or --NH--CO--R.sup.7, where R.sup.7 =(C.sub.1 -C.sub.6)-alkyl, and X is absent or is (C.sub.1 -C.sub.10)-alkyl, and R.sup.2, R.sup.3, R.sup.4 or R.sup.5, independently of one another, are hydrogen, (C.sub.1 -C.sub.5) -alkyl, lithium, sodium, potassium or Si(R), where R=(C.sub.1 -C.sub.
    Type: Grant
    Filed: December 12, 1997
    Date of Patent: August 10, 1999
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Christoph Naumann, Katsuhiro Yoshikawa, Kazuyuki Kitamura, Mizuho Inazu
  • Patent number: 5760271
    Abstract: A process for producing a polyorganophosphazene from a polyhalophosphazene. The polyhalophosphazene is reacted with a metal salt of an alkyl ester of hydroxybenzoic acid wherein the metal salt of the alkyl ester of hydroxybenzoic acid is contained in a homogeneous melt solution. The reaction of the polyhalophosphazene with the metal salt of an alkyl ester of hydroxybenzoic acid produces a macromolecular substituted polymer, which is reacted with a base to hydrolyze the polymer and produce the desired polyorganophosphazene product.
    Type: Grant
    Filed: August 18, 1997
    Date of Patent: June 2, 1998
    Assignee: Virus Research Institute, Inc.
    Inventors: Alexander K. Andrianov, Jonathan R. Sargent
  • Patent number: 5728853
    Abstract: A process for extracting metal values, especially zinc values, from aqueous solutions of metal salts, which comprises contacting the aqueous solution with an organic phase comprising a compound of the formula, ##STR1## wherein each of R.sup.1, R.sup.2, R.sup.3 and R.sup.4, independently, represents an optionally substituted hydrocarbyl or hydrocarbyloxy group or R.sup.1 and R.sup.2 together with the attached phosphorus atom and/or R.sup.3 and R.sup.4 together with the attached phosphorus atom from a 5- to 8-membered heterocyclic ring.
    Type: Grant
    Filed: July 11, 1996
    Date of Patent: March 17, 1998
    Assignee: Zeneca Limited
    Inventors: John Campbell, Raymond Frederick Dalton, Peter Michael Quan
  • Patent number: 5602270
    Abstract: New phosphazene derivatives, fully substituted by aromatic groups and perfluoropolyethereal chains, are utilized as stabilizers for oils and greases based on perfluoropoyethers. Such derivatives inhibit the degradation process affecting the perfluoropolyethereal chains when these are subjected to high temperatures in an oxidizing atmosphere and in the presence of metals, such as for example aluminium, titanium, vanadium and their alloys, or steels.
    Type: Grant
    Filed: May 19, 1995
    Date of Patent: February 11, 1997
    Assignee: Ausimont S.p.A.
    Inventors: Paolo Odello, Walter Navarrini, Richard D. Chambers, Costante Corti
  • Patent number: 5557003
    Abstract: A process for extracting metal values especially zinc values from aqueous solutions of metal salts which comprises contacting the aqueous solution with an organic phase comprising a compound of the formula: ##STR1## wherein each of R.sup.1, R.sup.2, R.sup.3 and R.sup.4, independently, represents an optionally substituted hydrocarbyl or hydrocarbyloxy group or R.sup.1 and R.sup.2 together with the attached phosphorus atom and/or R.sup.3 and R.sup.4 together with the attached phosphorus atom form a 5- to 8-membered heterocyclic ring.
    Type: Grant
    Filed: April 10, 1995
    Date of Patent: September 17, 1996
    Assignee: Zeneca Limited
    Inventors: John Campbell, Raymond F. Dalton, Peter M. Quan
  • Patent number: 5534646
    Abstract: Substituted 1,3,2,4-diazadiphosphetidines of formula I ##STR1## where preferably, R.sub.1 and R.sub.2 are branched alkyl or aryl, m and n are 1, p and q are 0, and YR.sub.3 and XR.sub.4 are substituted --O--phenyl or --N(alkyl).sub.2, are excellent stabilizers for organic materials, particularly polyolefins.
    Type: Grant
    Filed: August 31, 1994
    Date of Patent: July 9, 1996
    Assignee: Ciba-Geigy Corporation
    Inventor: Sai P. Shum
  • Patent number: 5442101
    Abstract: The invention relates to novel methylenebisphosphonic acid ester amide derivatives of general formula (I), in which formula W.sup.1, W.sup.2, W.sup.3 and W.sup.4 are independently the group OR.sup.1 or the group NR.sup.2 R.sup.3 wherein R.sup.1, R.sup.2 and R.sup.3 independently are hydrogen or straight or branched, optionally unsaturated C.sub.1 -C.sub.22 -alkyl, optionally substituted, optionally unsaturated C.sub.3 -C.sub.10 -cycloalkyl, aryl, aralkyl or silyl SiR.sub.3, or the groups R.sup.2 and R.sup.3 form together with the adjacent nitrogen atom a 3 to 10-membered saturated, partly saturated or aromatic heterocyclic ring, wherein in addition to the nitrogen atom, there may be one or two heteroatoms from the group N, O and S, provided that in formula (I) at least one of the groups W.sup.1, W.sup.2, W.sup.3 and W.sup.4 is hydroxy and at least one of the groups W.sup.1, W.sup.2, W.sup.3 and W.sup.4 is amino group NR.sup.2 R.sup.3, Q.sup.1 and Q.sup.
    Type: Grant
    Filed: October 20, 1993
    Date of Patent: August 15, 1995
    Assignee: Leiras Oy
    Inventors: Hannu Hanhijarvi, Heikki Nupponen, Jouko Vepsalainen, Esko Pohjala
  • Patent number: 5420330
    Abstract: Ether variant lipids bound to phosphoramidites are disclosed. These can be used to create oligonucleotides that are linked to stable lipid-like units. For example, dialkyl glycerols are linked to phosphoramidites.
    Type: Grant
    Filed: September 7, 1990
    Date of Patent: May 30, 1995
    Assignee: Pharmacia P-L Biochemicals Inc.
    Inventor: Charles K. Brush
  • Patent number: 5403909
    Abstract: Short-chain linear phosphazenes as well as products of their reactions with water, alcohols and organosiloxanes, and the like, are active catalysts for polycondensation and redistribution of organosiloxane polymers.
    Type: Grant
    Filed: July 15, 1993
    Date of Patent: April 4, 1995
    Assignee: General Electric Company
    Inventor: Slawomir Rubinsztajn
  • Patent number: 5294608
    Abstract: The invention describes tautomeric compounds of the formula Ia, Ib or Ic ##STR1## and/or their physiologically tolerable salts, in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 are a hydrogen atom, substituted (C.sub.1 -C.sub.7)-alkyl, (C.sub.3 -C.sub.10)-cycloalkyl, substituted phenyl or (C.sub.1 -C.sub.4)-alkylphenyl, R.sup.2 is substituted phosphoric acid, R.sup.2 and R.sup.3, R.sup.2 and R.sup.5 or R.sup.4 and R.sup.5 form a monocyclic 5- to 7-membered saturated or unsaturated heterocyclic ring which is mono- or polysubstituted, R.sup.8, R.sup.9, R.sup.10 and R.sup.11 are a hydrogen atom or (C.sub.1 -C.sub.5)-alkyl, X is a hydrogen atom, hydroxyl or halogen, l and n are an integer from 0 to 7, m is an integer from 0 to 2, and the sum of the numbers l, m and n is less than or equal to 10, a process for the preparation of the compounds of the formula Ia, Ib or Ic, pharmaceuticals and their use for the prophylaxis or treatment of osteoporosis.
    Type: Grant
    Filed: December 10, 1992
    Date of Patent: March 15, 1994
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Hans-Jochen Lang, Christoph Naumann, Denis Carniato, Anne-Marie Moura, Ryoichi Satoh, Masakazu Katoh
  • Patent number: 5273969
    Abstract: Compounds which are inhibitors of cholesterol biosynthesis (by inhibiting de novo squalene biosynthesis), and thus are useful as hypocholesterolemic agents and antiatherosclerotic agents are provided which have the structure ##STR1## wherein m is 0, 1, 2 or 3; n is 0, 1, 2, 3 or 4;Y.sup.1 and Y.sup.2 are H or halogen;R.sup.2, R.sup.3 and R.sup.4 may be the same or different and are independently H, metal ion, C.sub.1 to C.sub.8 alkyl or C.sub.3 to C.sub.12 alkenyl;X is O, S, NH or NCH.sub.2 R.sup.15 wherein R.sup.15 is H or C.sub.1 to C.sub.5 alkyl; andR.sup.1 is R.sup.5 --Q.sup.1 --Q.sup.2 --Q.sup.3 -- wherein R.sup.5, Q.sup.1, Q.sup.2 and Q.sup.3 are as defined herein;and when m is o, X is other than S; and if m is o and X is O, then n is 1, 2, 3 or 4; including all stereoisomers thereof.
    Type: Grant
    Filed: March 15, 1993
    Date of Patent: December 28, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Scott A. Biller, Michael J. Sofia
  • Patent number: 5212164
    Abstract: Compounds which are inhibitors of cholesterol biosynthesis (by inhibiting de novo squalene biosynthesis), and thus are useful as hypocholesterolemic agents and antiatherosclerotic agents are provided which have the structure ##STR1## wherein m is 0, 1, 2 or 3; n is 0, 1, 2, 3 or 4;Y.sup.1 and Y.sup.2 are H or halogen;R.sup.2, R.sup.3 and R.sup.4 may be the same or different and are independently H, metal ion, C.sub.1 to C.sub.8 alkyl or C.sub.3 to C.sub.12 alkenyl;X is O, S, NH or NCH.sub.2 R.sup.15 wherein R.sup.15 is H or C.sub.1 to C.sub.5 alkyl; andR.sup.1 is R.sup.5 --Q.sup.1 --Q.sup.2 --Q.sup.3 -- wherein R.sup.5, Q.sup.1, Q.sup.2 and Q.sup.3 are as defined herein;and when m is o, X is other than S; and if m is o and X is 0, then n is 1, 2, 3 or 4; including all stereoisomers thereof.
    Type: Grant
    Filed: March 29, 1990
    Date of Patent: May 18, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Scott A. Biller, Michael J. Sofia
  • Patent number: 5200545
    Abstract: This compound (I) is prepared by reaction of a compound (II) with carbon disulphide in the presence of an oxidizing agent. It can be used as an agent performing the triple function of initiator, chain transfer agent and termination agent in the radical polymerization of vinyl monomers. The .alpha.,.omega.-difunctional vinyl oligomers and polymers thus obtained are fireproofing polymers or polymers which can be employed as additives in the preparation of fireproofing polymers. They can also be employed to manufacture block polymers by condensation of their end functional groups in the presence of at least one other functional oligomer or polymer, these block polymers also being fireproofing polymers. ##STR1## R.sub.1, R.sub.2 =especially C.sub.1 -C.sub.12 alkyl optionally interrupted by --0--or, ##STR2## cycloalkyl, aryl, --Y--R.sub.4 (Y=single bond, --0-- or --NR.sub.5); R.sub.4 =phosphate or phosphonate functional group; at least one of R.sub.1 and R.sub.
    Type: Grant
    Filed: December 3, 1990
    Date of Patent: April 6, 1993
    Assignee: Elf Atochem S.A.
    Inventors: Gilbert Clouet, C. P. Reghunadhan Nair
  • Patent number: 5162405
    Abstract: The present invention comprises novel single-functional and mixtures of multi-functional oligomeric performance additive compounds having one or more components of Structure A R1 ? ? ##STR1## (The definitions of R, Z1, Z2, Z3, A1, A2, A3 and y are given in the Summary Section), their uses and polymeric compounds and compositions containing them which have enhanced oxidative stabilities, enhanced ultraviolet (UV) and light stabilites and/or enhanced flame retardance. An example is the bis sulfonic acid bispotassium salt reaction product from an oligomeric caprolactone diol (TONE.RTM. 260), 2-sulfobenzoic acid anhydride and potassium carbonate, and use of this product, at levels up to about 3.0%, in a general purpose bisphenol A polycarbonate resin, to enhance the fire resistance or flame retardance of the polycarbonate resin.
    Type: Grant
    Filed: March 22, 1991
    Date of Patent: November 10, 1992
    Assignee: ELF Atochem North America, Inc.
    Inventors: Ronald E. MacLeay, Jose Sanchez, Daryl L. Stein
  • Patent number: 5073284
    Abstract: A hydraulic fluid that remains solids-free at temperatures as low as about -30.degree. C. and has a pour point as low as about -42.degree. C. comprises a cyclic phosphazene oligomer mixture, the structural formula of each molecule of which contains 3 or 4 units selected at random from the group consisting of ##STR1## wherein R is a fluoroalkoxy group --OCH.sub.2 (CF.sub.2).sub.m CF.sub.2 Z, where Z is hydrogen or fluorine, and m is 0 or an integer from 1 to 10; R' and R" are different alkoxyalkyloxy groups in which linear or branched C.sub.1-12 alkoxy is substituted with linear or branched C.sub.1-12 alkoxy; with the proviso that all of R, R' and R" are present in the oligomer mixture.
    Type: Grant
    Filed: December 5, 1990
    Date of Patent: December 17, 1991
    Assignee: Ethyl Corporation
    Inventors: W. Dirk Klobucar, Charles H. Kolich
  • Patent number: 5070082
    Abstract: The N-phosphorylation of basic nitrogenous drug compounds to produce pro-drugs with enhanced water solubility or lipid solubility, or reduced toxicity, is disclosed. Drugs containing amine, amidine, guadinine, isourea, isothiourea an biguanide functions may be converted to such pro-drugs. The pro-drugs are hydrolyzed in the body, regenerating the original drugs with the release of a salt of phsophoric acid.
    Type: Grant
    Filed: March 18, 1991
    Date of Patent: December 3, 1991
    Assignee: American Cyanamid Company
    Inventors: Keith C. Murdock, Ving J. Lee