Having -c(=x)-, Wherein X Is Chalcogen, Attached Indirectly To Phosphorus By Acyclic Nonionic Bonding Patents (Class 558/160)
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Patent number: 11021496Abstract: The present invention relates to mesoporous organosilica nanoparticles, the method of preparation thereof, and uses of the same in treatment by means of photodynamic therapy or in imaging.Type: GrantFiled: January 18, 2017Date of Patent: June 1, 2021Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ DE MONTPELLIER, NANOMEDSYNInventors: Jean Olivier Durand, Jimenez Chiara Mauriello, Sebastien Richeter, Laurence Raehm, Magali Gary-Bobo, Marcel Garcia, Marie Maynadier
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Patent number: 8889657Abstract: The present invention provides phosphonate conjugates and methods of preparing the phosphonate conjugates so as to allow, for example, improved methods and compounds for modifying the surface of a nanoparticle to increase in vivo circulation times and targeted delivery performance.Type: GrantFiled: August 30, 2012Date of Patent: November 18, 2014Assignee: Mallinckrodt LLCInventor: Thomas E. Rogers
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Publication number: 20140121185Abstract: Novel compounds and pharmaceutical compositions thereof for the treatment and/or prevention of cancer and precancerous conditions, inflammation-related disorders, pain and fever.Type: ApplicationFiled: September 23, 2013Publication date: May 1, 2014Applicant: MEDICON PHARMACEUTICALS, INC.Inventor: Basil RIGAS
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Publication number: 20140030610Abstract: The present invention provides a nonaqueous electrolytic solution capable of improving electrochemical characteristics at high temperatures, which comprises at least one organic phosphorus compound represented by the following general formula (I), an energy storage device using the nonaqueous electrolytic solution, and a specific organic phosphorus compound. (In the formula, R1 and R2 each independently represent an alkyl group, a cycloalkyl group, an alkenyl group, an alkynyl group, an alkoxy group, a cycloalkoxy group, an alkenyloxy group, an alkynyloxy group, a halogenoalkyl group, a halogenoalkoxy group, an aryl group, or an aryloxy group; R3 and R4 each independently represent a hydrogen atom, a halogen atom, or an alkyl group; m is an integer of from 1 to 4, n is 0 or 1, q is 1 or 2. When q is 1 and n is 0, X represents an alkoxy group, an alkynyloxy group, an alkyloxyalkoxy group, an aryloxy group, etc.Type: ApplicationFiled: April 12, 2012Publication date: January 30, 2014Applicant: UBE Industries, LtdInventors: Koji Abe, Kei Shimamoto
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Publication number: 20140012028Abstract: A compound represented by following formula (I): A-L-{D1-(E)q-D2-(B)m—Z1—R}p. In the formula, A represents a p-valent chain or cyclic residue; L represents a single bond or a divalent linking group; p represents an integer of 2 or more; D1 represents a carbonyl group (—C(?O)—) or a sulfonyl group (—S(?O)2—); D2 represents a carbonyl group (—C(?O)—), a sulfonyl group (—S(?O)2—), a carboxyl group (—C(?O)O—), a sulfonyloxyl group (—S(?O)2O—), a carbamoyl group (—C(?O)N(Alk)-) or a sulfamoyl group (—S(?O)2N(Alk)-); E represents a divalent group; and R represents a hydrogen atom, a substituted or non-substituted C8 or longer alkyl group, a perfluoroalkyl group or a trialkylsilyl group.Type: ApplicationFiled: September 6, 2013Publication date: January 9, 2014Applicant: FUJIFILM CorporationInventors: Saisuke WATANABE, Hiyoku Nakata, Ken Kawata
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Publication number: 20130066098Abstract: The present invention provides phosphonate compounds and methods of preparing the phosphonate compounds so as to allow, for example, increased capability to modify nanoparticles for targeted drug delivery applications.Type: ApplicationFiled: August 30, 2012Publication date: March 14, 2013Applicant: Mallinckrodt LLCInventors: Thomas E. Rogers, Kah Tiong Kuan
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Publication number: 20120316139Abstract: Compounds of the general formula are disclosed with activity towards treating diseases related to inflammation, such as cancer, neurodegenerative and cardiovascular diseases. Pharmaceutical compositions and methods of use are also disclosed.Type: ApplicationFiled: July 27, 2012Publication date: December 13, 2012Inventor: Basil RIGAS
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Patent number: 8236820Abstract: Compounds of the general formula are disclosed with activity towards treating diseases related to inflammation, such as cancer, neurodegenerative and cardiovascular diseases. Pharmaceutical compositions and methods of use are also described.Type: GrantFiled: August 11, 2008Date of Patent: August 7, 2012Inventor: Basil Rigas
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Publication number: 20120046247Abstract: This invention relates to compounds of Formula (I), (II), or (III) as shown in the specification, which contain a 1,5-diphenylpenta-1,4-dien-3-one backbone. These compounds can be used to treat cancer, inflammatory disease, or autoimmune disease.Type: ApplicationFiled: August 16, 2011Publication date: February 23, 2012Inventors: Charles C-Y Shih, Toshio Kitamura, Qian Shi, Toshiyuki Kawashima, Hui-Kang Wang
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Publication number: 20110245367Abstract: Described herein is a degradable linking agent of formula Photo1-LG-Photo2, wherein Photo1 and Photo2 independently represent at least one photoreactive group and LG represents a linking group comprising one or more silicon atoms or one or more phosphorous atoms. The degradable linking agent includes a covalent linkage between at least one photoreactive group and the linking group, wherein the covalent linkage between at least one photoreactive group and the linking group is interrupted by at least one heteroatom. A method for coating a support surface with the degradable linking agent, coated support surfaces and medical devices are also described.Type: ApplicationFiled: March 29, 2011Publication date: October 6, 2011Applicant: SurModics, Inc.Inventors: Aleksey V. Kurdyumov, Dale G. Swan
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Patent number: 7915238Abstract: The present invention is directed to methods of treating diseases and disorders related to immune responses by administering one or more immunomodulatory compounds. In particular, the invention is directed to methods of stimulating and reducing immune responses, therapeutic and prophylactic treatment of cancer, treating autoimmune conditions, treating allergic reactions and asthma, and preventing ischemic damage and asthma by administering one or more immunomodulatory compounds.Type: GrantFiled: April 26, 2006Date of Patent: March 29, 2011Assignee: Eisai R & D Management Co., Ltd.Inventors: Lynn D. Hawkins, Sally T. Ishizaka
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Publication number: 20100297034Abstract: The present invention relates to osmolyte-containing preparations for the local treatment of dry mucous membranes. It describes the use of osmolytes for the production of a medicament, medical product or cosmetic product for the prevention, therapy and/or care of dry mucous membranes. The present invention relates to topical compositions based on osmolytes to which sodium chloride and/or moisturizers can optionally be added. The group of osmolytes proposed by the invention embraces various low-molecular substances, in particular ectoine, homoectoine, hydroxyectoine, di-myo-inositol phosphate (DIP), cyclic 2,3-diphosphoglycerate (cDPG), 1,1-di-glycerol phosphate (DGP), ?-mannosylglycerate (Firoin), ?-mannosylglyceramide (Firoin-A), di-mannosyl di-inositol phosphate (DMIP), glucosylglycerol and/or a derivative, e.g. an acid, salt or ester, of these compounds.Type: ApplicationFiled: October 29, 2008Publication date: November 25, 2010Applicant: BITOP AGInventor: Hans Bernd Schmittmann
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Publication number: 20090099137Abstract: Compounds of the general formula are disclosed with activity towards treating diseases related to inflammation, such as cancer, neurodegenerative and cardiovascular diseases. Pharmaceutical compositions and methods of use are also described.Type: ApplicationFiled: August 11, 2008Publication date: April 16, 2009Inventor: Basil Rigas
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Patent number: 7462733Abstract: Novel phosphonate compounds are provided including a phosphonoglyoxylamide ester, an ?-keto phosphonophosphinate ester, a carbonylbisphosphonate analog of a nucleotide, and a diazomethylenebisphosphonate analog of a nucleotide, as well as methods of making synthetically and medically useful ?-keto phosphonate compounds.Type: GrantFiled: July 30, 2002Date of Patent: December 9, 2008Assignee: University of Southern CaliforniaInventors: Charles E. McKenna, Boris A. Kashemirov, Patricia I. Bonaz-Krause
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Patent number: 7037486Abstract: The present invention provides novel compounds comprising cellular phosphoinositides and analogues tagged with stable or radioactive isotopes. The present invention also provides novel methods for the preparation of the said phosphoinositides by syntheses, and novel key intermediates of synthesis; the novel methods of synthesis are applied also for the preparation of the phosphoinositides in non-labelled form. In addition, the present invention discloses a class of novel compounds as isotope labelled key precursors of labelled phosphoinositides. These precursors are derivatives of the target phosphoinositides, labelled with stable or radioactive isotopes, wherein OH and phosphate groups are blocked with temporary protecting groups.Type: GrantFiled: January 24, 2002Date of Patent: May 2, 2006Assignee: Nutrimed BiotechInventor: Rajindra Aneja
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Publication number: 20040236135Abstract: Novel phosphonate compounds are provided including a phosphonoglyoxylamide ester, an &agr;-keto phosphonophosphinate ester, a carbonylbisphosphonate analog of a nucleotide, and a diazomethylenebisphosphonate analog of a nucleotide, as well as methods of making synthetically and medically useful &agr;-keto phosphonate compounds.Type: ApplicationFiled: May 28, 2004Publication date: November 25, 2004Inventors: Charles E. McKenna, Boris A Kashemirov, Patricia I Bonaz-Krause
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Patent number: 6787528Abstract: The compounds of formula (I) are hydrophilic aryl phosphate, thiophosphate, and aminophosphate intestinal apical membrane Na-mediated phosphate co-transportation inhibitors. The compounds can be administered orally, where they act to inhibit Na-dependent phosphate uptake in the intestines, or internally, where they interact with the phosphate control functions of the kidneys and parathyroid. They are therefore useful for inhibiting sodium-mediated phosphate uptake, reducing serum PTH, calcium, calcitriol, and phosphate, and treating renal disease in an animal, including a human.Type: GrantFiled: January 7, 2002Date of Patent: September 7, 2004Assignee: Board of Regents, The University of Texas SystemInventor: Brian E. Peerce
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Patent number: 6699910Abstract: The present invention relates to novel ketone compounds, compositions comprising ketone compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising a ketone compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.Type: GrantFiled: October 11, 2001Date of Patent: March 2, 2004Assignee: Esperion Therapeutics, Inc.Inventors: Jean-Louis Henri Dasseux, Carmen Daniela Oniciu
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Publication number: 20040034172Abstract: The present invention provides an acrylophosphate derivatives of the formula (I) 1Type: ApplicationFiled: December 10, 2002Publication date: February 19, 2004Applicant: CHUNG SHAN INSTITUTE OF SCIENCE & TECHNOLOGYInventors: Wen-Chiung Su, Ming-Te Shih
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Publication number: 20020151444Abstract: There are disclosed compounds of formula I 1Type: ApplicationFiled: March 28, 2002Publication date: October 17, 2002Inventors: Horst Zinke, Rolf Schumacher
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Patent number: 6384260Abstract: This invention provides analogues of phosphatidylinositol-phosphates modified at one or more selected inositol-hydroxyls and optionally carrying reporter or anchoring groups attached in the lipid or the inositol residues, and, the synthetic intermediates and methods for the preparation of these analogues. The analogues are useful as research reagents in biomedical studies related to structure, function and therapeuticals, including reference materials for analyzing the metabolic products in safety and efficacy studies of 2- and/or 3-hydroxyl modified inositols and phosphatidylinositols as drug candidates.Type: GrantFiled: April 3, 2001Date of Patent: May 7, 2002Assignee: Nutrimed BiotechInventor: Rajindra Aneja
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Patent number: 6380139Abstract: There are disclosed compounds of formula I wherein R1 and R2 are each independently of the other C3-C18alkyl, C5-C12cycloalkyl, C5-C6cycloalkylmethyl, C9-C10bicycloalkylmethyl, C9-C10tricycloalkylmethyl, phenyl, C7-C24alkylphenyl or, taken together, are R3 is C2-C18alkylene which is interrupted by —O—, —S—, or —NR4—, or is a group of formula R4 is hydrogen, C1-C18alkyl, phenyl-C1-C4alkyl, phenyl or C1-C6alkyl-substituted phenyl, R5 is hydrogen or methyl. These compounds are particularly suitable for use as additives for lubricant compositions, hydraulic fluids and machining fluids.Type: GrantFiled: May 26, 1995Date of Patent: April 30, 2002Assignee: Ciba Specialty Chemicals CorporationInventors: Horst Zinke, Rolf Schumacher
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Patent number: 6376697Abstract: The present invention provides novel compounds comprising cellular phosphoinositides and analogues tagged with stable or radioactive isotopes. The present invention also provides novel methods for the preparation of the said phosphoinositides by syntheses, and novel key intermediates of synthesis; the novel methods of synthesis are applied also for the preparation of the phosphoinositides in non-labelled form. In addition, the present invention discloses a class of novel compounds as isotope labelled key precursors of labelled phosphoinositides. These precursors are derivatives of the target phosphoinositides, labelled with stable or radioactive isotopes, wherein OH and phosphate groups are blocked with temporary protecting groups.Type: GrantFiled: April 15, 1999Date of Patent: April 23, 2002Assignee: Nutrimed BiotechInventor: Rajindra Aneja
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Patent number: 6333424Abstract: Compounds having utility in achieving the foregoing objects of the invention are prepared by reacting a 2,2-bis-(disubstituted-phosphoryl)-ethylsulfanyl-acetic acid compound with a pharmaceutically active chemical entity effective to treat the underlying disease state or with non-pharmaceutical entities such as pesticides, insecticides, fungicides or poisons for vermin.Type: GrantFiled: April 8, 1999Date of Patent: December 25, 2001Assignee: Eliza Nor Biopharmaceuticals, Inc.Inventors: Pal Herczegh, John F. Hartmann, Arpad Kovacs, Ferenc J. Sztaricskai, Miklos Hornyak
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Patent number: 6232486Abstract: This invention provides analogues of phosphatidylinositol-phosphates modified at one or more selected inositol-hydroxyls and optionally carrying reporter or anchoring groups attached in the lipid or the inositol residues, and, the synthetic intermediates and methods for the preparation of these analogues. The analogues are useful as research reagents in biomedical studies related to structure, function and therapeuticals, including reference materials for analyzing the metabolic products in safety and efficacy studies of 2- and/or 3-hydroxyl modified inositols and phosphatidylinositols as drug candidates.Type: GrantFiled: June 10, 1997Date of Patent: May 15, 2001Assignee: Nutrimed BiotechInventor: Rajindra Aneja
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Patent number: 6191253Abstract: A dispersant for aqueous mill-bases obtainable by reacting a polyethylene glycol with a molar excess of a hydroxycarboxylic acid containing from 4 to 17 carbon atoms or lactone thereof and/or with a C3-4-alkylene oxide to form a polymeric diol and phosphating the diol. The preferred hydroxycarboxylic acid or lactone is &egr;-caprolactone.Type: GrantFiled: June 9, 1998Date of Patent: February 20, 2001Assignee: Zeneca LimitedInventors: John David Schofield, Dean Thetford
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Patent number: 6160153Abstract: The present invention provides crosslinking, conjugating and reducing agents which are functional with at least one phosphorothioate monoester group (--SPO.sub.3.sup.--2). Crosslinking and conjugation methods as well as solid phase reagents and conjugates which are useful in immunoassays are also provided.Crosslinking and conjugating agents of the invention generally comprise a compound corresponding to the formula (I), shown below, wherein n at least 1 and Q is a straight or branched monomer, polymer or oligomer having an average molecular weight between about 200 and about 1,000,000. Additionally, when n is 1, Q comprises at least 1 additional reactive functionality.Q--(S--PO.sub.3.sup.-2).sub.n (I)The reducing agents that are provided conform to a compound of the formula (Y), shown below, wherein (A) and (Z) can be independently selected from C.sub.1 -C.sub.5 alkyl and CONH(CH.sub.2).sub.p wherein p is an integer between 1 and 5.Type: GrantFiled: February 3, 2000Date of Patent: December 12, 2000Assignee: Abbott LaboratoriesInventors: Christopher Bieniarz, Douglas F. Young, Michael J. Cornwell, Zbigniew Skrzypczynski
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Patent number: 6096916Abstract: Disclosed are unique starting materials, reaction sequences and intermediate compounds for the preparation of D-3-phosphorylated phosphoinositides (3-PPI) of unambiguous structure and absolute stereochemistry. The enantiomerically pure D-3-phosphorylated phosphoinositides also provided have many uses, including in the development of diagnostics and therapeutics based on the roles of 3-PPI in intracellular signaling.Type: GrantFiled: July 27, 1999Date of Patent: August 1, 2000Assignee: Nutrimed BiotechInventor: Rajindra Aneja
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Patent number: 6020506Abstract: Disclosed are unique starting materials, reaction sequences and intermediate compounds for the preparation of D-3-phosphorylated phosphoinositides (3-PPI) of unambiguous structure and absolute stereochemistry. The enantiomerically pure D-3-phosphorylated phosphoinositides also provided have many uses, including in the development of diagnostics and therapeutics based on the roles of 3-PPI in intracellular signaling.Type: GrantFiled: May 23, 1997Date of Patent: February 1, 2000Assignee: Nutrimed BiotechInventor: Rajindra Aneja
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Patent number: 6008398Abstract: A phosphorus ester oligomer having the structure: wherein A can be the same or different in each monomeric unit and each is independently selected from the group consisting of oxygen, sulfur, lower alkyl, substituted or unsubstituted alkylamino, substituted or unsubstituted arylamino and aminoalkyl; B.sub.1 and B.sub.2 can be the same or different and each is independently selected from hydrogen, lower alkyl, a labeling group, a protecting group, a phosphoramidate or a phosphomonoester; R.sub.1 can be the same or different in each monomeric unit, and in at least one of the non-nucleotide monomeric units, R.sub.Type: GrantFiled: February 1, 1996Date of Patent: December 28, 1999Assignee: Genzyme CorporationInventors: Robert Gerard Gentles, Alan F. Cook, Morris Jonathan Rudolph, Reza Fathi
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Patent number: 5955453Abstract: Membrane-permeant phosphoinositides, including phosphatidylinositol phosphate esters, are described. A membrane-permeant phosphoinositide includes groups that neutralize the charges of the phosphate moieties of the phosphoinositide. A cell can be treated with the membrane-permeant phosphoinositide, which is then absorbed into the cell. The neutralizing groups can be removed intracellularly to afford the charged phosphoinositide.Type: GrantFiled: April 24, 1998Date of Patent: September 21, 1999Assignee: The Regents of the University of CaliforniaInventors: Roger Y. Tsien, Tao Jiang
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Patent number: 5866548Abstract: Caged acyloxyalkyl esters of phosphate-containing inositol phosphates which are capable of permeating cell membranes. The second messengers are protected (caged) at the 6-hydroxyl, with a photolabile group. Once inside the cell, the ester derivatives undergo enzymatic conversion to remove the acyloxyalkyl ester groups. The resulting caged compound remains biologically inactive until exposed to ultraviolet (UV) light. Upon UV light exposure, the active form of the second messenger is released within the cell.Type: GrantFiled: December 19, 1996Date of Patent: February 2, 1999Assignee: The Regents of the University of CaliforniaInventors: Roger Y. Tsien, Wenhong Li
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Patent number: 5834436Abstract: Acyloxyalkyl esters of phosphate-containing second messengers which are capable of permeating cell membranes. Once inside the cell, the ester derivatives undergo enzymatic conversion to the biologically active form of the second messenger. The acyloxyalkyl esters have the formula: ##STR1## wherein A.sub.1 to A.sub.6 is H, OH, F or ##STR2## wherein R is an alkyl group having from 2 to 6 carbon atoms and R' is H or CH.sub.3 or R is CH.sub.3 and R' is CH.sub.3 and wherein at least one of A.sub.1 to A.sub.6 is a phosphoester having the formula set forth above.Type: GrantFiled: June 7, 1995Date of Patent: November 10, 1998Assignee: The Regents of the University of CaliforniaInventors: Roger Y. Tsien, Carsten Schultz, Wenhong Li
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Patent number: 5785894Abstract: A dispersant for aqueous mill-bases obtainable by reacting a polyethylene glycol with a molar excess of a hydroxycarboxylic acid containing from 4 to 17 carbon atoms or lactone thereof and/or with a C.sub.3-4 -alkylene oxide to form a polymeric diol and phosphating the diol. The preferred hydroxycarboxylic acid or lactone is .epsilon.-caprolactone.Type: GrantFiled: December 13, 1996Date of Patent: July 28, 1998Assignee: Zeneca LimitedInventors: John David Schofield, Dean Thetford
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Patent number: 5686633Abstract: Inks, particularly inks for ink jet printing, contain at least one compound of the formula I ##STR1## as a stabilizer. The symbols R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.3 ' and R.sub.4 ' are as defined in claim 1. The compounds are in part novel and are suitable for use as light stabilizers for organic materials.Type: GrantFiled: December 31, 1991Date of Patent: November 11, 1997Assignee: Ciba Specialty Chemicals CorporationInventors: Eric Vieira, Hugh Stephen Laver
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Patent number: 5650531Abstract: The synthesis of a non-halogen flame retardant oligomer containing highly pendnat phosphorus moieties is disclosed. Diols, unsaturated double bond-containing dicarboxylic acids or acid anhydrides and saturated dicarboxylic acids or acid anhydrides are first esterified to form an oligomeric unsaturated polyester, and then a phsophorus-containing compound is grafted onto the oligomeric unsaturated polyester through addtion reaction in the presence of a selected metal complex catalyst.Type: GrantFiled: June 28, 1995Date of Patent: July 22, 1997Assignee: Industrial Technology Research InstituteInventors: Shinn-Jen Chang, Yuung-Ching Sheen, Yi-Ni Cheng, Rong-Shuh Chang
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Patent number: 5631392Abstract: The invention relates to a process for preparing an aldehyde compound by hydroformylation of an ethylenically unsaturated organic compound, using a catalyst system which includes a Group VIII metal and a novel bidentate phosphite ligand. The bidentate phosphite ligand has a chemical structure according to formula (1), ##STR1## wherein R.sup.1 and R.sup.3 are respectively substituted or unsubstituted organic groups which may be the same or different, and wherein R.sup.2 is a substituted or unsubstituted tetravalent organic group.Type: GrantFiled: November 17, 1995Date of Patent: May 20, 1997Assignees: DSM N.V., E.I. Du Pont de Nemours and CompanyInventors: Carolina B. Hansen, Antonius J. J. M. Teunissen
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Patent number: 5614573Abstract: Flame retardant compounds including at least one of a group of specified phosphoryl compounds which have a phenylene group in the molecule are applied to fiber materials composed of polyester-based synthetic fibers. Sufficiently long-lasting flame retardancy may be imparted to polyester-based synthetic fiber materials without the use of halogen compounds.Type: GrantFiled: March 27, 1995Date of Patent: March 25, 1997Assignees: Nicca Chemical Co., Ltd., Kanebo LimitedInventors: Junji Sano, Kunio Ichihashi, Hajime Saito, Hirotomo Banko
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Patent number: 5512189Abstract: A reaction product useful as an antiwear or antioxidant additive in lubricants is made by reacting a sulfur-containing carboxylic acid, i.e. 3,3'-thiodipropionic acid and a phosphorodithioate, i.e. butoxylated bis(2-ethylhexyl) phosphorodithioic acid.Type: GrantFiled: July 22, 1994Date of Patent: April 30, 1996Assignee: Mobil Oil CorporationInventors: Shi-Ming Wu, Andrew G. Horodysky
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Patent number: 5476888Abstract: The diposphines have the formula (I) ##STR1## wherein: R.sup.2, R.sup.3 and R.sup.4 independently from each other represent a hydrocarbyl group which is substituted with one or more radicals selected from the group consisting of halogen, alkyl and alkoxy, andA is --C(O)--, --S(O).sub.2 --, --S(O)-- or certain divalent organic groups.The diphosphines are useful for stabilizing thermoplastic polymers, such as polycarbonates, against thermal discoloration.Type: GrantFiled: September 2, 1994Date of Patent: December 19, 1995Assignee: The Dow Chemical CompanyInventors: Jurgen Eiffler, Gunter A. Juptner, David P. Flores
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Patent number: 5451401Abstract: Polyphosphonic acid ester compounds with flavorant, coolant and/or sweetener components, and tartar, plaque and/or calculus control compositions with improved taste comprising one or more polyphosphonic acid ester compounds are described.Type: GrantFiled: September 29, 1993Date of Patent: September 19, 1995Assignee: The Procter & Gamble CompanyInventors: Kim W. Zerby, Jeffrey C. Hayes
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Patent number: 5438048Abstract: Novel pharmacologically active methylenebisphosphonates having formula (I) wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 independently are straight or branched, optionally unsaturated C.sub.1 -C.sub.10 -alkyl, optionally unsaturated C.sub.3 -C.sub.10 -cycloalkyl, aryl, aralkyl, silyl SiR.sub.3 or hydrogen, whereby in formula (I) at least one of the groups R.sup.1, R.sup.2, R.sup.3 or R.sup.4 is hydrogen and at least one of the groups is different from hydrogen, Q.sup.1 is hydrogen, hydroxyl, halogen, amino NH.sub.2, or OR', wherein R' is C.sub.1 -C.sub.4 -lower alkyl or acyl, Q.sup.2 is straight or branched, optionally unsaturated C.sub.1 -C.sub.10 -alkyl, -hydroxyalkyl or -aminoalkyl, whereby the oxygen may, as a substituent, contain one group or the nitrogen as a substituent may contain one or two groups, which are C.sub.1 -C.sub.4 -lower alkyl or acyl, or the two substituents of the nitrogen form together with the nitrogen atom a saturated, partly saturated or an aromatic heterocyclic ring, or Q.sup.Type: GrantFiled: October 20, 1993Date of Patent: August 1, 1995Assignee: Leiras OyInventors: Hannu Nikander, Marjaana Heikkila-Hoikka, Esko Pohjala, Hannu Hanhijarvi, Leena Lauren
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Patent number: 5401845Abstract: Compounds of the formula I ##STR1## in which x is 1, 2 or 3, and, if x=1, R.sup.1 is C.sub.1 -C.sub.30 alkyl, C.sub.1 -C.sub.18 alkyl substituted by halogen, --COOR.sup.2, --CN, --NR.sup.3 R.sup.4 or by --CONR.sup.3 R.sup.4, C.sub.2 -C.sub.18 alkyl which is interrupted by --NR.sup.5 --, --O-- or --S--, C.sub.3 -C.sub.18 alkenyl, C.sub.5 -C.sub.12 cycloalkyl, phenyl-C.sub.1 -C.sub.4 alkyl, phenyl which is unsubstituted or substituted by C.sub.1 -C.sub.12 alkyl, halogen, phenyl-C.sub.1 -C.sub.4 alkyl and/or C.sub.1 -C.sub.4 alkoxy, or R.sub.1 is naphthyl, a radical of the formula ##STR2## R.sub.2, R.sub.3, R.sub.4 and R.sub.5, independently of one another, are hydrogen, C.sub.1 -C.sub.18 alkyl, C.sub.5 -C.sub.12 cycloalkyl or phenyl-C.sub.1 -C.sub.4 alkyl, R.sup.6 is hydrogen, methyl, allyl or benzyl, R.sup.7 is hydrogen or --OR.sup.9, R.sup.8 is hydrogen or methyl, R.sup.9 is hydrogen or C.sub.1 -C.sub.30 alkyl, R.sup.10 and R.sup.11, independently of one another, are hydrogen or C.sub.1 -C.sub.Type: GrantFiled: March 11, 1994Date of Patent: March 28, 1995Assignee: Ciba-Geigy CorporationInventors: Rita Pitteloud, Peter Hofmann, Rudolf Maul, Volker Schenk, Eduard Troxler, Horst Zinke
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Patent number: 5391801Abstract: A hydroformylation process for preparing a hydroformylated product by reacting an olefinic compound with hydrogen and carbon monoxide in the presence of a Group VIII metal catalyst, in the reaction of which there is present a phosphite compound having the formula (I), ##STR1## wherein R.sup.1 and R.sup.2 are respectively an aromatic hydrocarbon groups which may be the same or different and the aromatic hydrocarbon group has at least a hydrocarbon group on a carbon atom adjacent to a carbon atom bonded with an oxygen atom as a substituent; A.sup.1 is an n-valent organic group having an aliphatic hydrocarbon group, a cycloaliphatic hydrocarbon group or an aromatic hydrocarbon group bonded with an adjacent oxygen atom, which may respectively have a substituent; n is an integer of from 2 to 4; and the respective [--O--P(OR.sup.1)(OR.sup.2)] group may be the same or different.Type: GrantFiled: April 16, 1993Date of Patent: February 21, 1995Assignee: Mitsubishi Kasei CorporationInventors: Keiichi Sato, Yuji Kawaragi, Masaki Takai, Tooru Ookoshi
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Patent number: 5347040Abstract: Onium salt capable of generating acid upon exposure to actinic radiation having the following structure:(R.sub.1).sub.a (R.sub.2).sub.b (R.sub.3).sub.c Q.sup.+ --A--M.sup.+ X.sup.- --B--X'.sup.-where:Q is S;R.sub.1, R.sub.2 and R.sub.3 are independently substituted or unsubstituted aromatic, aliphatic, or aralkyl groups having 7-18 carbon atoms;M.sup.+ is a cationic organic radical;A is a divalent radical selected from the group of hindered alkylene groups, substituted or unsubstituted aromatic or aralkyl groups;B is a divalent aromatic sensitizer which absorbs radiation having a wavelength longer than 300 nm and is capable of transferring an electron to Q,x.sup.- and X'.sup.- are anionic groups; and wherein A provides a spatial separation between Q and M, and B provides a spatial separation between X and X', such that the spatial separation provided by A between Q and M is substantially the same as the spatial separation provided by B between X and X'.Type: GrantFiled: December 9, 1992Date of Patent: September 13, 1994Assignee: E. I. Du Pont de Nemours and CompanyInventors: Arnost Reiser, Xiaohua He
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Patent number: 5306841Abstract: A compound having the formula ##STR1## where X is a radical of myo-inositol or a radical of a configuration isomer thereof where at least one R is ##STR2## where Y is (1) oxygen, (2) a straight or branched alkyl with 1-10 carbon atoms, where Z is ##STR3## where A.sup.1 and A.sup.2 are the same or different and are hydrogen or methyl and n is 3-10, or ##STR4## where A.sup.1 and A.sup.2 are hydrogen or methyl and where m is 1-5, where R.sup.1 is hydrogen, straight or branched alkyl, aryl or alkaryl, alkoxy or aryloxy, where R.sup.2 is(1) R.sup.1,(2) hydroxyl, or(3) OZOCOR.sup.1,and where the remaining R is/are hydroxyl.Type: GrantFiled: July 2, 1993Date of Patent: April 26, 1994Inventors: Hans Bundgaard, deceased, by Charlotte Bundgaard, legal representative
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Patent number: 5153000Abstract: A novel monophosphate and a novel diphosphate prepared by a phosphatidyl transfer reaction of a phospholipid and an alcohol in the presence of phospholipase D are disclosed. The phosphates can independently or together form small and stable liposomes which can include active components therein. Cosmetic compositions comprising these phosphates or liposomes penetrate well into the hair and the skin, and exhibit long-lasting excellent moisture-retaining, beauty, skin-activation effects.Type: GrantFiled: November 16, 1989Date of Patent: October 6, 1992Assignees: Kao Corporation, Meito Sangyo Co., Ltd.Inventors: Yoshiko Chikawa, Katsumi Kita, Mitsuharu Masuda, Tomihiro Kurosaki, Takashi Itoh, Noriko Inoue, Haruya Kato, Takashi Imamura, Yasuo Ishii, Yoshitaka Kokusho, Akira Tsunoda, Shigeaki Kato
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Patent number: 5103311Abstract: The invention describes a processor system suitable for processing video signal samples on a real-time basis. Signals are derived from the samples for driving an imaging unit. For this purpose, one or more processor modules are provided with processor elements, operating in parallel in time, which are connected to a crossbar switch. A module contains at least one arithmetic/logic processor element and at least one memory processor element. Moreover, there is a clock device, the frequency of which bears a fixed relationship to the frequency with which the video signal samples are obtained.Type: GrantFiled: October 1, 1990Date of Patent: April 7, 1992Assignee: U.S. Philips CorporationInventors: Robert J. Sluijter, Cornelis M. Huizer, Hendrik Dijkstra, Gerrit A. Slavenburg
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Patent number: 5023312Abstract: There is disclosed lubricant additives that comprise a combination of meadowfoam oil as a triglyceride or a wax ester, sulfurized triglyceride meadowfoam oil or sulfurized wax ester of meadowfoam oil, amnd phosphite adducts of triglyceride meadowfoam oil or wax ester of meadowfoam oil. There is also disclosed a proceess for sulfurizing triglyceride meadowfoam oil that is soluble in a lubricant base, such as mineral oil.Type: GrantFiled: April 19, 1990Date of Patent: June 11, 1991Inventors: Frank L. Erickson, Robert E. Anderson, Phillip S. Landis
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Patent number: RE38334Abstract: Disclosed are unique starting materials, reaction sequences and intermediate compounds for the preparation of D-3-phosphorylated phosphoinositides (3-PPI) of unambiguous structure and absolute stereochemistry. The enantiomerically pure D-3-phosphorylated phosphoinositides also provided have many uses, including the development of diagnostics and therapeutics based on the roles of 3-PPI in intracellular signaling.Type: GrantFiled: January 31, 2002Date of Patent: November 25, 2003Assignee: Nutrimed BiotechInventor: Rajindra Aneja