Halogen Attached Directly To The Phosphorus By Nonionic Bonding Patents (Class 558/202)
-
Patent number: 11345977Abstract: Processing schemes for the extraction and/or separation of rare earth elements (REEs) from rare earth containing products such as rare earth mineral ore bodies and intermediate products derived from rare earth mineral ore bodies. The processing schemes may be applied independently or in various combinations to produce end-products that have a very high purity with respect to REEs, including high value critical REEs. The processes may include acid digestion, formation of rare earth oxalate compounds, metathesizing of rare earth oxalate compounds, selective precipitation and/or solvent extraction to form the high purity REE end products.Type: GrantFiled: October 13, 2015Date of Patent: May 31, 2022Assignee: Rare Element Resources Ltd.Inventor: Henry Kasaini
-
Patent number: 8501978Abstract: A process for manufacturing a polyfluroalkanoyl phosphorodichloridate comprising reacting a polyfluoroalkanol having the general formula Rf—CH2—OH, wherein Rf is a linear or branched C1-C8 perfluoroalkyl group optionally interrupted by O, with at least 4 moles of POCl3 per mole of Rf—CH2—OH in the presence of 0.1 to 0.2 moles of LiCl catalyst per mole of Rf—CH2—OH at a temperature between 95° C. and 110° C. to form a phosphorodichloridate of the general formula Rf—CH2—O—P(O)Cl2.Type: GrantFiled: October 6, 2011Date of Patent: August 6, 2013Assignee: E I du Pont de Nemours and CompanyInventor: Ming-Hong Hung
-
Patent number: 8293724Abstract: Fatty acid amide hydrolase (FAAH) is an enzyme responsible for the degradation of oleamide (an endogenous sleep-inducing lipid) and anandamide (an endogenous ligand for cannabinoid receptors). Disclosed herein are potent inhibitors of FAAH and methods for their use for treating a variety of disorder, including hypertension and cardiac hypertrophy.Type: GrantFiled: April 6, 2010Date of Patent: October 23, 2012Assignee: The United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: George Kunos, Alexandros Makriyannis
-
Publication number: 20120010173Abstract: The invention relates to a compound of formula (I) and the salts, N-oxides, quaternary amines, and stereoisomers thereof, wherein R1 to R8 are as defined in the claims. The invention further relates to intermediates and methods for the preparation of the compounds of formula (I). The invention also relates to the compounds of formula (I) for use as a medicament, particularly for the prevention or treatment of fungal infections.Type: ApplicationFiled: March 3, 2010Publication date: January 12, 2012Applicant: SEPS PHARMA N.V.Inventors: Yves Rene Johanna Paul Gonnissen, Jody Firmin Marceline Voorspoels
-
Publication number: 20110319303Abstract: Alkylphosphorofluoridothioates containing alkyl groups of greater than four carbons which exhibit significantly lower wear volume compared to ZDDP, methods of making same with high yields, and methods of using same as lubricant additives.Type: ApplicationFiled: June 24, 2011Publication date: December 29, 2011Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMInventors: Xin Chen, Pranesh B. Aswath, Ronald L. Elsenbaumer
-
Publication number: 20100261674Abstract: Fatty acid amide hydrolase (FAAH) is an enzyme responsible for the degradation of oleamide (an endogenous sleep-inducing lipid) and anandamide (an endogenous ligand for cannabinoid receptors). Disclosed herein are potent inhibitors of FAAH and methods for their use for treating a variety of disorder, including hypertension and cardiac hypertrophy.Type: ApplicationFiled: April 6, 2010Publication date: October 14, 2010Inventors: George Kunos, Alexandros Makriyannis
-
Publication number: 20100093985Abstract: A subject of the invention is the use of at least one cytosolic phospholipase A2 (cPLA2) inhibitor in the preparation of a medicament intended for the preventive and/or curative symptomatic treatment of cystic fibrosis, particularly of the increased secretion of mucus in cystic fibrosis.Type: ApplicationFiled: April 5, 2007Publication date: April 15, 2010Applicants: INSTITUT PASTEUR, INST NAT DE LA SANTE ET DE LA RECHER. MED (INSERM)Inventors: Fariel Dif, Lhousseine Touqui
-
Publication number: 20090163723Abstract: Disclosed is a low cost, efficient method for production of a salt composed of an arylsulfonium and a fluorinated alkylfluorophosphate which method does not required a large excess amount of acid. The method comprises reacting an aryl compound Ar—H and with a compound represented by the formula (I), wherein R1 and R2 denote a hydrocarbon group or a heterocycle group which may be substituted, or they are bonded with each other directly or via —O—, —S—, —SO—, —SO2—, —NH—, —NR?—, —CO—, —COO—, —CONH—, an alkylene group having 1 to 3 carbon atoms or a phenylene group to form a ring structure which may be substituted, wherein R? denotes a C1-5 alkyl group or a C6-10 aryl group; in the presence of an acid represented by the formula (2), wherein Rf denotes an alkyl group 80% or more of whose hydrogen atoms are substituted by fluorine atoms, “a” is an integer of 1 to 5; and a dehydrating agent to produce the salt of sulfonium represented by the formula (3).Type: ApplicationFiled: November 24, 2006Publication date: June 25, 2009Inventors: Hideki Kimura, Jiro Yamamoto, Shinji Yamashita
-
Patent number: 6465687Abstract: Novel thyroid receptor ligands are provided which have the general formula (I) where R1 is alkyl of 1 to 4 carbons or cycloalkyl of 3 to 7 carbons; R2 and R3 are the same or different and are hydrogen, halogen, alkyl of 1 to 3 carbons or cycloalkyl of 3 to 5 carbons, at least one of R2 and R3 being other than hydrogen; n is an integer from 0 to 4; R4 is an aliphatic hydrocarbon, an aromatic hydrocarbon, carboxylic acid ester thereof, alkenyl carboxylic acid or ester thereof, hydroxy, halogen, cyano, or a phosphonic acid or an ester thereof, or a pharmaceutically acceptible salt thereof. A method for treating diseases associated with metabolism dysfunction or which are dependent on the expression of a T3 regulated gene, such as obesity, hypercholesterolemia, osteoporosis, hypothyroidism, and goiter, is also provided.Type: GrantFiled: March 20, 2000Date of Patent: October 15, 2002Assignee: Karo Bio ABInventors: Yi-Lin Li, Ye Liu, Asa Hedfors, Johan Malm, Charlotta Mellin, Minsheng Zhang
-
Patent number: 6031091Abstract: A versatile reagent with a non-nucleotide monomeric unit having a ligand, and first and second coupling groups which are linked to the non-nucleotide monomeric unit. The ligand can be either a chemical moiety, such as a label or intercalator, or a linking arm which can be linked to such a moiety. Such reagent permits preparation of versatile nucleotide/non-nucleotide polymers, having any desired sequence of nucleotide and non-nucleotide monomeric units, each of the latter of which bear a desired ligand. These polymers can for example, be used as probes which can exhibit enhanced sensitivity and/or which are capable of detecting a genus of nucleotides each species of which has a common target nucleotide sequence of interest bridged by different sequences not of interest.Type: GrantFiled: August 7, 1997Date of Patent: February 29, 2000Assignee: Gen-Probe IncorporatedInventors: Lyle J. Arnold, Jr., Mark A. Reynolds, Ram S. Bhatt
-
Patent number: 6018067Abstract: Crude dihydrocarbylchlorothiophosphate product contaminated with dihydrocarbylpolysulfide and/or dihydrocarbylchlorophosphate is upgraded by treating the crude product with an aqueous hypochlorite solution, and separating an aqueous phase from the organic, then drying to obtain the resultant product.Type: GrantFiled: February 12, 1999Date of Patent: January 25, 2000Assignee: Albemarle CorporationInventors: William B. Harrod, David Edward Raposa, Dean Allen Raucstadt, Donald S. Vash
-
Patent number: 5955626Abstract: Crude dihydrocarbylchlorothiophosphate product contaminated with dihydrocarbylpolysulfide and/or dihydrocarbylchlorophosphate is upgraded by treating the crude product with chlorine followed by an aqueous solution of reducing agent, separating an aqueous phase from the organic, then drying to obtain the resultant product.Type: GrantFiled: February 12, 1999Date of Patent: September 21, 1999Assignee: Albemarle CorporationInventors: William B. Harrod, Thomas J. Callender, David Edward Raposa
-
Patent number: 5585481Abstract: A versatile reagent with a non-nucleotide monomeric unit having a ligand, and first and second coupling groups which are linked to the non-nucleotide monomeric unit. The ligand can be either a chemical moiety, such as a label or intercalator, or a linking arm which can be linked to such a moiety. Such reagent permits preparation of versatile nucleotide/non-nucleotide polymers, having any desired sequence of nucleotide and non-nucleotide monomeric units, each of the latter of which bear a desired ligand. These polymers can for example, be used as probes which can exhibit enhanced sensitivity and/or which are capable of detecting a genus of nucleotides each species of which has a common target nucleotide sequence of interest bridged by different sequences not of interest.Type: GrantFiled: January 14, 1994Date of Patent: December 17, 1996Assignee: Gen-Probe IncorporatedInventors: Lyle J. Arnold, Jr., Mark A. Reynolds, Ram S. Bhatt
-
Patent number: 5401845Abstract: Compounds of the formula I ##STR1## in which x is 1, 2 or 3, and, if x=1, R.sup.1 is C.sub.1 -C.sub.30 alkyl, C.sub.1 -C.sub.18 alkyl substituted by halogen, --COOR.sup.2, --CN, --NR.sup.3 R.sup.4 or by --CONR.sup.3 R.sup.4, C.sub.2 -C.sub.18 alkyl which is interrupted by --NR.sup.5 --, --O-- or --S--, C.sub.3 -C.sub.18 alkenyl, C.sub.5 -C.sub.12 cycloalkyl, phenyl-C.sub.1 -C.sub.4 alkyl, phenyl which is unsubstituted or substituted by C.sub.1 -C.sub.12 alkyl, halogen, phenyl-C.sub.1 -C.sub.4 alkyl and/or C.sub.1 -C.sub.4 alkoxy, or R.sub.1 is naphthyl, a radical of the formula ##STR2## R.sub.2, R.sub.3, R.sub.4 and R.sub.5, independently of one another, are hydrogen, C.sub.1 -C.sub.18 alkyl, C.sub.5 -C.sub.12 cycloalkyl or phenyl-C.sub.1 -C.sub.4 alkyl, R.sup.6 is hydrogen, methyl, allyl or benzyl, R.sup.7 is hydrogen or --OR.sup.9, R.sup.8 is hydrogen or methyl, R.sup.9 is hydrogen or C.sub.1 -C.sub.30 alkyl, R.sup.10 and R.sup.11, independently of one another, are hydrogen or C.sub.1 -C.sub.Type: GrantFiled: March 11, 1994Date of Patent: March 28, 1995Assignee: Ciba-Geigy CorporationInventors: Rita Pitteloud, Peter Hofmann, Rudolf Maul, Volker Schenk, Eduard Troxler, Horst Zinke
-
Patent number: 5362906Abstract: The present invention is directed to farnesyl pyrophosphate analogs which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention, and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.Type: GrantFiled: June 18, 1993Date of Patent: November 8, 1994Assignee: Merck & Co., Inc.Inventors: Neville J. Anthony, Ta-Jyh Lee, Robert L. Smith, Gerald E. Stokker
-
Patent number: 5344930Abstract: Compounds of the general formula: ##STR1## are useful as surfactants in the preparation of fluorocarbon emulsions, which can be used as oxygen-carrying blood substitutes, and for many other therapeutic and diagnostic applications. They are further useful in liposomal formulations which are themselves therapeutic agents or provide a vehicle for such agents.Type: GrantFiled: November 8, 1993Date of Patent: September 6, 1994Assignee: Alliance Pharmaceutical Corp.Inventors: Jean G. Riess, Francois Jeanneaux, Marie-Pierre Krafft, Catherine Santaella, Pierre Vierling
-
Patent number: 5283350Abstract: Aryl esters of phosphonous halides of the formula I ##STR1## in which R' is a phenyl or benzyl radical which bears 1 to 3 substituents, .alpha.-methylbenzyl, .alpha., .alpha.-dimethylbenzyl, naphthyl or a naphthyl radical bearing 1 to 5 substituents, where the substituents are identical or different and are a non-aromatic hydrocarbon radical, an alkoxy radical or alkylthio radical each having 1 to 8 carbon atoms, aryl or aryloxy each having 6 to 10 carbon atoms or halogen having an atomic number from 9 to 35,R.sup.2 is a non-aromatic hydrocarbon radical having 1 to 18 carbon atoms, aryl, arylmethyl, arylethyl or arylisopropyl, where each aryl contains 6 to 10 carbon atoms,R.sup.3 is hydrogen or one of the groups mentioned under R.sup.2, andX is chlorine or bromine.The invention further relates to a process for the preparation of aryl esters of phosphonous halides of the formula I.Type: GrantFiled: December 30, 1992Date of Patent: February 1, 1994Assignee: Hoechst AktiengesellshaftInventors: Manfred Bohshar, Hans-Jerg Kleiner
-
Patent number: 5166144Abstract: The invention relates to new O-halogenocyclobutyl S-alkyl (di)thiophosphoric acid ester-amides of the general formula (I) ##STR1## in which A represents fluorine or chlorine,B represents hydrogen or alkyl,X represents oxygen or sulphur,R.sup.1 represents hydrogen, alkyl, --COH (formyl) or --CO-alkyl (acyl) which is optionally substituted by halogen,R.sup.2 represents hydrogen or alkyl, andR.sup.3 represents alkyl or alkoxyalkyl,which can be used as agents for combating pests.Type: GrantFiled: March 20, 1992Date of Patent: November 24, 1992Assignee: Bayer AktiengesellschaftInventors: Bernd-Wieland Kruger, Dietmar Bielefeldt, Karl-R. Gassen, Jurgen Hartwig, Wilhelm Stendel, Christoph Erdelen
-
Patent number: 5164383Abstract: O-Halogenocyclopentyl S-alkyl (di)thiphosphoric(phosphonic) acid ester derivatives of the general formula (I) ##STR1## in which R.sup.1 represents alkyl, alkoxy or the radical ##STR2## R.sup.3 represents hydrogen or alkyl and R.sup.4 represents hydrogen, alkyl, --COH (formyl) or optionally halogen-substituted --CO-alkyl (acyl),R.sup.2 represents alkyl or alkoxyalkyl andX represents oxygen or sulphur,can be used as pesticides.Type: GrantFiled: March 20, 1992Date of Patent: November 17, 1992Assignee: Bayer AktiengesellschaftInventors: Bernd-Wieland Kruger, Michael Negele, Jurgen Hartwig, Christoph Erdelen, Wilhelm Stendel
-
Patent number: 5064820Abstract: Compounds of the general formula I ##STR1## wherein R1 represents --R3, --OR3 or --N(R3).sub.2, in which R3 is alkyl of 1 to about 18 carbon atoms;R2 represents alkyl of 1 to about 18 carbon atoms; andX represents --OR3, halogen, --CN, --SR4 or --N(R4).sub.2, in which R4 is alkyl of 1 to about 5 carbon atoms,which the proviso that at least one of R2 and R3 is a pheromone alkyl chain. Members of this class of compounds have been shown to exhibit outstanding activity in disrupting pheromone-mediated behavior of various insects, in particular moths.Type: GrantFiled: December 19, 1989Date of Patent: November 12, 1991Assignee: Regents of the University of CaliforniaInventors: T. Roy Fukuto, Richard S. Vetter, Thomas C. Baker, Mangel S. Malik
-
Patent number: 4981989Abstract: Antihypertensive phosphate derivatives having the following formula are described: ##STR1## wherein X is selected from one or more of: (a) C.sub.1 -C.sub.24 branched or straight chain alkyl; (b) C.sub.1 -C.sub.24 branched or straight chain alkoxy; (c) ##STR2## wherein n and m are integers from 0 to 25 and the sum of n and m is less than or equal to 25; phenyl; substituted phenyl wherein the substituents are selected from the group consisting of C.sub.1 -C.sub.20 branched or straight chain alkyl, C.sub.1 -C.sub.20 branched or straight chain alkoxy, halogen, trifluoromethyl, phenyl, and substituted phenyl, phenoxy; and substituted phenoxy, wherein the substituents are selected from the group consisting of C.sub.1 -C.sub.20 branched or straight chain alkyl, halogen, trifluoromethyl, phenyl and substituted phenyl; Q is selected from the group consisting of: ##STR3## wherein R.sub.1 is selected from the group consisting of hydrogen, C.sub.1 -C.sub.4 branched or straight chain alkyl, C.sub.1 -C.sub.Type: GrantFiled: November 8, 1989Date of Patent: January 1, 1991Assignee: American Cyanamid CompanyInventors: Allan Wissner, Phaik E. Sum, Robert E. Schaub
-
Patent number: 4924024Abstract: Compounds which are useful as inhibitors of cholesterol biosynthesis and thus as hypocholesterolemic agents are provided which have the structure ##STR1## wherein Q is ##STR2## or a bond; Z is --(CH.sub.2).sub.n -- or --(CH.sub.2).sub.p --CH.dbd.CH--(CH.sub.2).sub.m --, wherein n is 1 to 5; p is 0, 1 or 2; m is 0, 1 or 2;R, R.sup.1 and R.sup.1a are the same or different and are H, lower alkyl or a metal ion; andR.sup.2 and R.sup.3 may be the same or different and are H or halogen.New intermediates used in preparing the above compounds and method for preparing same, pharmaceutical compositions containing such compounds and a method for using such compounds to inhibit cholesterol biosynthesis are also provided.Type: GrantFiled: June 1, 1989Date of Patent: May 8, 1990Assignee: E. R. Squibb & Sons, Inc.Inventor: Scott A. Biller
-
Patent number: 4867907Abstract: Aryl fluorophosphites have been found to be effective polymer stabilizers and are hydrolytically stable when used to form aqueous suspensions.Type: GrantFiled: July 27, 1987Date of Patent: September 19, 1989Assignee: Ethyl CorporationInventors: Lester P. J. Burton, Morris Blumberg
-
Patent number: 4855474Abstract: The aldehyde RCHO is reacted with PCl.sub.3 and sulfur monochloride in the presence of chloride ion and under anhydrous conditions to give RCHClO(S)PCl.sub.2.Type: GrantFiled: March 18, 1987Date of Patent: August 8, 1989Assignee: E. I. Du Pont De Nemours and CompanyInventors: Mohamed H. Fahmy, James R. Sanborn
-
Patent number: 4769364Abstract: Pesticidally active novel phosphates of the formula ##STR1## in which R represents hydrogen, alkyl, cycloalkyl, alkoxy, alkylthio, alkylamino, dialkylamino or aryl,R.sup.1 represents alkyl,R.sup.2 represents fluoroalkyl andX represents oxygen or sulphur.The acid halides of the formula ##STR2## are also new.Type: GrantFiled: July 15, 1986Date of Patent: September 6, 1988Assignee: Bayer AktiengesellschaftInventors: Fritz Maurer, Bernhard Homeyer, Wilhelm Stendel
-
Patent number: 4670576Abstract: Organic esters of chlorine-containing or bromine-containing phosphorus acids and BIS-GMA, as well as organic esters of phosphorus acids having chlorine or bromine bonded directly to phosphorus, the organic radical of said esters containing at least one polymerizable functional group. Also described are dental liner, restorative, composite, and adhesive compositions containing such organic esters, as well as methods for using such compositions to repair or veneer dental tissue.Type: GrantFiled: October 29, 1984Date of Patent: June 2, 1987Assignee: Minnesota Mining and Manufacturing CompanyInventor: James E. Bunker