Nitrogen Attached Indirectly To The Sulfate Group By Acyclic Nonionic Bonding Patents (Class 558/29)
-
Patent number: 11161808Abstract: There is disclosed a cyclic process for producing taurine from monoethanolamine comprising the steps of: (a) reacting monoethanolamine with ammonium sulfate in the recycling mother liquor to yield monoethanolamine sulfate; (b) reacting the monoethanolamine sulfate with sulfuric acid to form 2-aminoethyl hydrogen sulfate ester; (c) subjecting the 2-aminoethyl hydrogen sulfate ester to a sulfonation reaction with ammonium sulfite to yield taurine and ammonium sulfate; (d) separating the taurine and the ammonium sulfate by means of solid-liquid separation; (e) removing the excess ammonium sulfite from the mother liquor to obtain an aqueous solution comprised of ammonium sulfate and (f) returning the aqueous solution to step (a) to complete the cyclic process.Type: GrantFiled: September 9, 2020Date of Patent: November 2, 2021Assignee: Vitaworks IP, LLCInventor: Songzhou Hu
-
Patent number: 8637688Abstract: The present invention relates to pharmaceutical dosage forms for topical administration comprising a tri-substituted glycerol compound or a pharmaceutically acceptable salt thereof. The invention also relates to a corresponding method for preparing such dosage forms as well as to their use as medicaments for the treatment of cancer and immune diseases.Type: GrantFiled: November 9, 2007Date of Patent: January 28, 2014Inventors: Julia Diederichs, Wolfgang Richter, Lutz Weber
-
Patent number: 7888524Abstract: Process for the preparation of sulfuric acid monoesters of aminoalkanols by reacting sulfuric acid with aminoalkanols and removing the water forming in the reaction from the reaction mixture, sulfuric acid and at least one aminoalkanol being mixed and the hot reaction mixture forming being passed with turbulent flow into a container and being quenched therein with a fluid.Type: GrantFiled: November 23, 2006Date of Patent: February 15, 2011Assignee: BASF AktiengesellschaftInventors: Jacques Dupuis, Reinhard Hoffmann, Ekhard Winkler, Manfred Winter
-
Publication number: 20100125146Abstract: A method of making a phenylethylamine of formula B: wherein R2, R3, R4, R5, R6, R?, R? and Rn are each independently selected from hydrogen, alkyl, acyl, aryl, amido, amino acids, sugars and nucleotides. The method includes the reduction of a compound of formula A in the absence of base: wherein R2, R3, R4, R5, R6, R?, R? and Rn are as defined above.Type: ApplicationFiled: November 19, 2008Publication date: May 20, 2010Applicant: Johnson Matthey Public Limited CompanyInventors: James J. Mencel, Paul Fishbein
-
Publication number: 20090181932Abstract: A synthetic compound characterized by having the structure of formula I or II or a pharmaceutically acceptable salt and/or hydrate thereof is provided. Formula I and formula II are defined as follows. wherein R1 is substituted aryl or substituted heteroaryl; R2 and R3 are independently selected from the group consisting of CF3, substituted phenyl, C1-C4 alkyl, substituted C1-C4 alkyl, (CF3)nC1-C4alkyl, (CF3)n(substituted C1-C4 alkyl), provided that when R2 or R3 is CF3, the other is not an unsubstituted alkyl; R4 and R4? are independently selected from the group consisting of M, C1-C4 alkyl, phenyl, and benzyl, wherein M is a metal ion is selected from the group consisting of sodium, lithium, calcium, magnesium and potassium, or R4 and R4? are taken together to form a cyclic structure. Methods of making such compounds and uses thereof are also provided.Type: ApplicationFiled: January 7, 2009Publication date: July 16, 2009Applicant: WyethInventors: David Zenan LI, Dane Springer, Sayed Elmarakby, Appavu Chandrasekaran, Anthony F. Kreft, III
-
Publication number: 20090149668Abstract: This invention relates to a method for producing compounds of formula (I) wherein R1 is a straight- or branched-chain C1-C24 alkyl, C2-C24-alkenyl or C1-C24-alkyl ether group or CH2CN or a group of the formula R2 and R3 are each individually a C1-C8-alkyl or C1-C4-hydroxyalkyl group. The method according to the invention is characterized by reacting a tertiary amine of the formula NR1R2R3 with chloroacetonitrile in an organic solvent and then adding an alkylating substance R11-Z, being C1-C4 alky.Type: ApplicationFiled: March 16, 2007Publication date: June 11, 2009Inventors: Lars Cuypers, Werner Janitschek, Isabel Scheffer
-
Publication number: 20080319215Abstract: Process for the preparation of sulfuric acid monoesters of aminoalkanols by reacting sulfuric acid with aminoalkanols and removing the water forming in the reaction from the reaction mixture, sulfuric acid and at least one aminoalkanol being mixed and the hot reaction mixture forming being passed with turbulent flow into a container and being quenched therein with a fluid.Type: ApplicationFiled: November 23, 2006Publication date: December 25, 2008Applicant: BASF SEInventors: Jacques Dupuis, Reinhard Hoffmann, Ekhard Winkler, Manfred Winter
-
Patent number: 6962909Abstract: Aminosterol compounds are described that are useful as inhibitors of the sodium/proton exchanger (NHE). Methods of using such aminosterols compounds are also enclosed, including those employing compounds that are inhibitors of a spectrum of NHEs as well as those using compounds that are inhibitors of only one specific NHE. Advantageous screening techniques and assays for evaluating a compound's therapeutic activity are also disclosed.Type: GrantFiled: November 2, 2001Date of Patent: November 8, 2005Assignee: Genaera CorporationInventors: Michael Zasloff, Ann Shinnar, William Kinney, Steven Jones
-
Patent number: 6177552Abstract: Described are fiber-reactive water-soluble azo compounds which contain a group of the general formula (2) as diazo component where R21 is hydrogen, methyl, ethyl, methoxy, ethoxy or sulfo, R22 is hydrogen, methyl, ethyl, methoxy, ethoxy or sulfo, R23 is hydrogen, alkyl of 1 to 4 carbon atoms or phenyl, n is 2 or 3 and the group —SO2—Y is a fiber-reactive group of the vinyl sulfone series, and which are capable of dyeing hydroxy- and/or carboxamido-containing material, especially fiber material, such as cellulose fibers, for example cotton, or regenerated cellulose fibers and also wool and synthetic polyamide fibers in high color strength and good fastnesses.Type: GrantFiled: December 28, 1999Date of Patent: January 23, 2001Assignee: DyStarTextilfarben GmbH & Co. Deutschland KGInventors: Uwe Reiher, Ron Pedemonte
-
Patent number: 6111102Abstract: Compounds of the formula I or salts thereof, in whichX is oxygen, --O--NR.sup.2 -- or --SO.sub.2 --NR.sup.2 --, and Y is N or CH,R.sup.1 is (C.sub.1 -C.sub.6)alkyl, (C.sub.2 -C.sub.6)alkenyl or (C.sub.2 -C.sub.6)alkynyl, which are in each case optionally substituted, or, in the case where X=oxygen, also (subst.) phenyl,R.sup.2 is H, (C.sub.1 -C.sub.6)alkyl, (C.sub.2 -C.sub.6)alkenyl or -alkynyl or (C.sub.3 -C.sub.6)cycloalkyl,R.sup.3 and R.sup.4 are H, (subst.) (C.sub.1 -C.sub.4)alkyl or (subst.) (C.sub.1 -C.sub.4)alkoxy or halogen, (C.sub.1 -C.sub.4)alkylthio, (C.sub.1 -C.sub.4)-alkylamino or di[(C.sub.1 -C.sub.4)alkyl]-amino,R.sup.5 is H or (C.sub.1 -C.sub.4)alkyl and R.sup.6 is hydrogen,may be prepared by reacting compounds of the formula II,R.sup.1 --X--R.sup.7 (II)with compounds of the formulae III, IV and VR.sup.8 --OCN (III)SO.sub.2 Cl.sub.2 (IV) ##STR1## where R.sup.7 and R.sup.8 are H, a quarternary ammonium ion or one equivalent of a metal cation.Type: GrantFiled: March 2, 1999Date of Patent: August 29, 2000Assignee: Hoechst AktiengesellschaftInventor: Gunter Schlegel
-
Patent number: 5912379Abstract: Processes for preparing sulfonylureas Compounds of the formula I or salts thereof, ##STR1## in which X is oxygen, --O--NR.sup.2 -- or --SO.sub.2 --NR.sup.2 --, and Y is N or CH,R.sup.1 is (C.sub.1 -C.sub.6)alkyl, (C.sub.2 -C.sub.6)alkenyl or (C.sub.2 -C.sub.6)alkynyl, which are in each case optionally substituted, or, in the case where X=oxygen, also (subst.) phenyl,R.sup.2 is H, (C.sub.1 -C.sub.6)alkyl, (C.sub.2 -C.sub.6)alkenyl or -alkynyl or (C.sub.3 -C.sub.6)cycloalkyl,R.sup.3 and R.sup.4 are H, (subst.) (C.sub.1 -C.sub.4)alkyl or (subst.) (C.sub.1 -C.sub.4)alkoxy or halogen, (C.sub.1 -C.sub.4)alkylthio, (C.sub.1 -C.sub.4)alkylamino or di?(C.sub.1 -C.sub.4)alkyl!-amino,R.sup.5 is H or (C.sub.1 -C.sub.4)alkyl and R.sup.6 is hydrogen,may be prepared by reacting compounds of the formula II,R.sup.1 --X--R.sup.7 (II)with compounds of the formulae III, IV and VR.sup.8 --OCN (III)SO.sub.2 Cl.sub.2 (IV) ##STR2## where R.sup.7 and R.sup.8 are H, a quarternary ammonium ion or one equivalent of a metal cation.Type: GrantFiled: May 25, 1995Date of Patent: June 15, 1999Assignee: Hoechst AktiengesellschaftInventor: Gunter Schlegel
-
Patent number: 5906985Abstract: Pharmaceutical compounds of the formula ##STR1## in which n is 0, 1 or 2 and m is 1 or 2, R.sup.1 is hydrogen, C.sub.1-10 alkyl, C.sub.2-10 alkenyl, C.sub.2-10 alkynyl, phenyl, naphthyl, C.sub.1-10 alkyl-phenyl, C.sub.2-10 alkenyl-phenyl or C.sub.2-10 alkynyl-phenyl, said phenyl and naphthyl groups being optionally substituted, R.sup.2 is hydrogen or a protecting group, and Q is an acidic group; or a salt or ester thereof.Type: GrantFiled: August 21, 1997Date of Patent: May 25, 1999Assignees: Eli Lilly and Company Limited, Lilly, S.A.Inventors: Stephen Richard Baker, Almudena Rubio Esteban, John Goldsworthy, Concepcion Pedregal Tercero
-
Patent number: 5840936Abstract: Aminosterol compounds are described that are useful as inhibitors of the sodium/proton exchanger (NHE). Methods of using such aminosterols compounds are also enclosed, including those employing compounds that are inhibitors of a spectrum of NHEs as well as those using compounds that are inhibitors of only one specific NHE. Advantageous screening techniques and assays for evaluating a compound's therapeutic activity are also disclosed.Type: GrantFiled: June 7, 1995Date of Patent: November 24, 1998Assignee: Magainin Pharmaceuticals Inc.Inventors: Michael Zasloff, Ann Shinnar, Meena Rao, William Kinney
-
Patent number: 5686642Abstract: Reactive dyestuffs which, in the form of the free acid, correspond to the following formula ##STR1## wherein D is the radical of an organic dyestuff of the mono-azo, polyazo or metal complex azo series and the other substituents have the meaning given in the description, show improved application properties.Type: GrantFiled: July 16, 1996Date of Patent: November 11, 1997Assignee: Bayer AktiengesellschaftInventors: Konrad Bootz, Manfred Hoppe, Eckhard Bock, Wolfram Reddig, Thomas Eizenhofer, Wolfgang Harms, Karl-Josef Herd
-
Patent number: 5663442Abstract: The invention relates to a process for the preparation of compounds of the formula ##STR1## characterized in that the radical X in sulphones of the formulaX--(CH.sub.2 --CH.sub.2 --O).sub.m --(CH.sub.2).sub.n --SO.sub.2 --CH.sub.2 --CH.sub.2 OH (2)is replaced by ##STR2## or a compound of the formula ##STR3## is added to the sulphone of the formulaCH.sub.2 =CH--SO.sub.2 --CH.sub.2 --CH.sub.2 --OH (3),the substituents having the meanings given in the description.Type: GrantFiled: May 31, 1995Date of Patent: September 2, 1997Assignee: Bayer AktiengesellschaftInventors: Wolfgang Harms, Udo-Winfried Hendricks, Karl-Josef Herd, Klaus Kunde
-
Patent number: 5525732Abstract: Di-, tri- and poly-perfluoroalkyl-substituted alcohols and acids and derivatives thereof are described which are prepared from perfluoroalkyl iodides and di-, tri- or polyallyl alcohols or acids. These compounds contain two or more perfluoroalkyl-iodoalkyl or perfluoroalkyl-alkenyl groups and one or two alcohol or acid groups or derivatized alcohol or acid functions. They can be reacted with isocyanates, epoxy compounds, anhydrides, acids or acid derivatives to prepare a great variety of oil- and water-repellent compositions which are useful for oil- and water-repellent treatment of textiles, glass, paper, leather and other substrates.Type: GrantFiled: May 31, 1995Date of Patent: June 11, 1996Assignee: Ciba-Geigy CorporationInventors: Marlon Haniff, Robert Falk, Ted Deisenroth, Karl F. Mueller
-
Patent number: 5468870Abstract: Dye-donor element for use according to thermal dye sublimation transfer comprising a support having thereon a dye layer containing a dye corresponding to the following formula ##STR1## wherein Z represents CN, COOR.sup.1 or CONR.sup.2 R.sup.3 ;R.sup.1, R.sup.2 and R.sup.3 each independently represent hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, or R.sup.2 and R.sup.3 together represent the necessary atoms to close a heterocyclic nucleus or substituted heterocyclic nucleus;Y represents OR.sup.4 or NR.sup.5 R.sup.6 or CN;R.sup.4 represents hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, SO.sub.2 R.sup.7, COR.sup.7, CSR.sup.7, POR.sup.7 R.sup.8 ;R.sup.5 and R.sup.6 each independently has one of the significances given to R.sup.4 or represent substituted or unsubstituted amino, or R.sup.5 and R.sup.Type: GrantFiled: October 20, 1994Date of Patent: November 21, 1995Assignee: AGFA-GAVAERT, N.V.Inventor: Luc J. Vanmaele
-
Patent number: 5463100Abstract: Aminoaryl .beta.-sulfatoethyl sulfone compounds, such as, for example 4-(.beta.-sulfatoethylsulfonyl)-aniline, can be prepared in a quick and easy manner from their corresponding .beta.-hydroxyethyl sulfone compounds by sulfation by spraying a solution or suspension or paste of this aminoaryl .beta.-hydroxyethyl sulfone compound or the acylamino compound thereof in sulfuric acid or aqueous sulfuric acid into a hot inert gas stream of a convection dryer. In this procedure, the drying, esterification reaction and the hydrolysis of any acylamino group present takes place synchronously. The sulfato compound is preferably obtained in the form of granules.Type: GrantFiled: September 6, 1994Date of Patent: October 31, 1995Assignee: Hoechst AktiengesellschaftInventor: Walter Rupp
-
Patent number: 5416234Abstract: Process for the preparation of 3'-aminopropyl 2-sulfatoethyl sulfone in high yield, which comprises reacting allylamine with mercaptoethanol in aqueous sulfuric acid in a one-pot process at temperatures from about 25.degree. C. to the boiling point of the reaction mixture in the presence of free-radical initiators which are soluble in the reaction medium, oxidizing the reaction mixture thus obtained with hydrogen peroxide in the presence of catalytic amounts of a compound of a transition metal of the periodic table of elements as oxidation catalyst to give 3'-aminopropyl 2-hydroxyethyl sulfone hemisulfate, adding further sulfuric acid until the total amount of sulfuric acid in the mixture is at least 1 mol, relative to the allylamine used, and esterifying the 3'-aminopropyl 2-hydroxyethyl sulfone hemisulfate obtained after oxidation by evaporation to dryness or with sulfuric acid or oleum or chlorosulfonic acid in solution.Type: GrantFiled: August 25, 1993Date of Patent: May 16, 1995Assignee: Hoechst AktiengesellschaftInventors: Michael Meier, Heinrich Angenendt, Georg Grotsch
-
Patent number: 5405947Abstract: Reactive dyestuffs which, in the form of the free acid, have the following formula ##STR1## in which X denotes fluorine, chlorine or bromine andSO.sub.2 -Z denotes a specific reactive radical,the remaining substituents having the meaning given in the description, and show improved fixation yield in dyeing.Type: GrantFiled: April 27, 1993Date of Patent: April 11, 1995Assignee: Bayer AktiengesellschaftInventors: Manfred Hoppe, Eckhard Bock, Wolfram Reddig, Thomas Eizenhofer, Wolfgang Harms, Karl-Josef Herd
-
Patent number: 5387674Abstract: There are described formazan dyes of the formula ##STR1## where n is 1 or 2,Kat.sup..sym. is the equivalent of a cation,Me is copper or nickel,X is a radical of the formula CO--O or SO.sub.2 --O,Y is vinyl or a radical of the formula C.sub.2 H.sub.4 --Q, where Q is a group which is detachable under alkaline reaction conditions,the ring A may be substituted and benzofused, the ring B is substituted and may be benzofused, and the ring C may be substituted, the use thereof for dyeing or printing hydroxyl- or nitrogen-containing organic substrates, and novel hydrazones.Type: GrantFiled: September 8, 1993Date of Patent: February 7, 1995Assignee: BASF AktiengesellschaftInventors: Claus Marschner, Manfred Patsch
-
Patent number: 5336800Abstract: Oxamides useful as dye intermediates have the formula ##STR1## where R.sup.1 and R.sup.2 are independently of each other hydrogen, C.sub.1 -C.sub.4 -alkyl or phenyl,X is hydroxyl, nitro or a radical of the formula --NR.sup.3 R.sup.4, where R.sup.3 is hydrogen or C.sub.1 -C.sub.4 -alkanoyl and R.sup.4 is hydrogen, C.sub.1 -C.sub.4 -alkyl or phenyl,Z is C.sub.2 -C.sub.8 -alkylene, substituted or unsubstituted phenylene or substituted or unsubstituted naphthylene, or X--Z and R.sup.1 are, together with the nitrogen atom joining them together, the radical of the formula ##STR2## where R.sup.3 is as defined above,L is a bridge member andY is vinyl or a radical of the formula --C.sub.2 H.sub.4 --A, where A is hydroxyl or a group which is detachable under alkaline reaction conditions.Type: GrantFiled: January 4, 1993Date of Patent: August 9, 1994Assignee: BASF AktiengesellschaftInventors: Bernd Siegel, Manfred Patsch, Knut Kessel
-
Patent number: 5329040Abstract: In the process for the continuous preparation of aminoaryl or aminoalkyl .beta.-sulfatoethyl sulfones by reaction of the corresponding .beta.-hydroxyethyl sulfones with sulfuric acid in a molar ratio of 1:1 to 1:1.15 at temperatures above 120 .degree. C. a mixture of a .beta.-hydroxyethyl sulfone with sulfuric acid is supplied to a fluidized bed of end product produced by recycling and mechanical stirring. The mixture is reacted at 100.degree. to 200.degree. C.Type: GrantFiled: April 21, 1992Date of Patent: July 12, 1994Assignee: Hoechst AktiengesellschaftInventors: Lothar Schmitt, Rudiger Berthold
-
Patent number: 5281740Abstract: In a method for preparing 3'aminopropyl-2-sulphatoethylsulphone in a one-pot process, allyl amine is reacted with mercaptoethanol in dilute sulphuric acid at temperatures of approximately 50.degree. C. up to the boiling point in the presence of a radical starter. The resultant reaction mixture is oxidized with hydrogen peroxide, in the presence of catalytic quantities of a compound of a transition metal of the periodic system of the elements as an oxidation catalyst, at temperatures of approximately 70 to 100.degree.C. and evaporated to dryness after addition of sufficient sulphuric acid to bring the total sulphuric acid content of the mixture to at least 1 mol, referred to the quantity of allyl amine used.Type: GrantFiled: September 4, 1992Date of Patent: January 25, 1994Assignee: Hoechst AktiengesellschaftInventors: Michael Meier, Heinrich Angenendt
-
Patent number: 5256774Abstract: Improved reactive dyestuffs have the following formula ##STR1## in which the substituents have the meaning given in the description.Type: GrantFiled: February 20, 1992Date of Patent: October 26, 1993Assignee: Bayer AktiengesellschaftInventors: Wolfgang Harms, Thomas Eizenhofer
-
Patent number: 5232915Abstract: 9.alpha.-Hydroxy-19,11.beta.-bridged steroids of general formula I ##STR1## are described. The more detailed meaning of A, B, R.sup.1, R.sup.2, G, Z, R.sup.4 --Y and R.sup.4' --Y' follows from the description. The steroids of general formula I have antigestagen and/or antiglucocorticoidal action and can be used for the production of pharmaceutical agents.Type: GrantFiled: January 14, 1992Date of Patent: August 3, 1993Assignee: Schering AktiengesellschaftInventors: Eckhard Ottow, Gunter Neef, Rudolf Wiechert, Walter Elger, Sybille Beier, Karl-Heinrich Fritzemeier
-
Patent number: 5216138Abstract: There are described water soluble azo compounds conforming to the formula (1)D--N.dbd.N--K (1)where D is a radical of the formula (2), (2a) or (2b) ##STR1##where Y is a substituent which is eliminable by alkali to form a vinyl group, Y.sup.2 has one of the meanings of Y or is hydroxyl, X is chlorine or bromine, and R is hydrogen, lower alkyl, phenyl or halogen, and K is a radical of a singly couplable coupling component which may additionally contain an azo group, or the radical of a doubly couplable coupling component.The compounds of the formula (1) have fiber-reactive properties and are very highly suitable for use as dyes for dyeing hydroxy- and/or carboxamido-containing material, in particular fiber material, for example cellulose-fiber materials, wool and synthetic polyamide fibers, in strong, fast shades.There are also described novel starting compounds of the formulae (7), (7a) and (7b) ##STR2##where Y.sup.2, X and R are each as defined above, x is zero or 2 and W is nitro or amino.Type: GrantFiled: November 27, 1991Date of Patent: June 1, 1993Assignee: Hoechst AktiengesellschaftInventor: Jorg Dannheim
-
Patent number: 5210187Abstract: Double attachment reactive dyes have the formula ##STR1## where U.sup.1 is C.sub.1 -C.sub.4 -alkyl, phenyl, C.sub.2 -C.sub.10 -alkenyl or the radical ##STR2## where Q.sup.1 and Q.sup.2 are each independently of the other hydrogen or C.sub.1 -C.sub.4 -alkyl and Q.sup.3 is a group which is detachable under alkaline reaction conditions,Z is the radical ##STR3## where each Q.sup.4 is independently of the other hydrogen or C.sub.1 -C.sub.4 -alkyl which may be substituted by cyano, U.sup.2 is C.sub.1 -C.sub.4 -alkyl, phenyl, C.sub.2 -C.sub.10 -alkenyl or the radical ##STR4## where Q.sup.5 and Q.sup.6 are each independently of the other hydrogen or C.sub.1 -C.sub.4 -alkyl and Q.sup.7 is a group which is detachable under alkaline reaction conditions, and w is 0, 1 or 2,t is 0, 1 or 2,v is 1 or 2 and X and L are each as defined in the description, with the proviso that at least one of the two radicals U.sup.1 and U.sup.2 is not C.sub.1 -C.sub.Type: GrantFiled: April 9, 1992Date of Patent: May 11, 1993Assignee: BASF AktiengesellschaftInventors: Manfred Patsch, Uwe Nahr, Friedrich Wirsing, Joerg L. Jessen, Klaus Pandl, Claus Marschner, Matthias Dust
-
Patent number: 5155271Abstract: The invention relates to a process for the preparation of compounds of the formula ##STR1## in which Q is substituted or unsubstituted C.sub.1 -C.sub.6 alkyl, A is a direct bond or a bridging member, s is the number 1 or 2, Z is a radical of the formula --CH.sub.2 CH.sub.2 OH, --CH.dbd.CH.sub.2 or --CH.sub.2 CH.sub.2 --Y, and Y is a leaving group, and the benzene or napthalene nucleus I can be further substituted, which comprises reacting compounds of the formula ##STR2## with compounds of the formulaQ--OH (3)in which A, s, Z and Q are as defined under formula (1), in the presence of hydrogenation catalysts, and then carrying out further conversion reactions where appropriate.The compounds obtained by the process according to the invention are suitable as intermediates for the preparation of reactive dyes.Type: GrantFiled: June 25, 1990Date of Patent: October 13, 1992Assignee: Ciba-Geigy CorporationInventor: Peter Aeschlimann
-
Patent number: 5147456Abstract: The present invention relates to novel compounds represented by the formula: ##STR1## wherein R is an alkyl group having from about 8 to about 18 carbon atoms, and mixtures thereof, n has a value from 1 to 6, R.sub.1 is selected from the group consisting of an alkyl group having from 1 to about 12 carbon atoms, H, or ##STR2## wherein the sum of n-m=3 to 12, Z.dbd.H or SO.sub.3 M and M.dbd.NH.sub.4, Na, or K. These compounds possess antimicrobial activity and are useful as cleaning agents and preservatives, particularly in water-base functional fluids and surface coating compositions.Type: GrantFiled: October 18, 1991Date of Patent: September 15, 1992Assignee: Olin CorporationInventors: Michael Scardera, Frank R. Grosser
-
Patent number: 5142089Abstract: Dye corresponding to the following formula - ##STR1## wherein Z represents CN, COOR.sup.1 or CONR.sup.2 R.sup.3 ;R.sup.1, R.sup.2 and R.sup.3 each independently represents hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, or R.sup.2 and R.sup.3 together represent the necessary atoms to close a heterocyclic nucleus or substituted heterocyclic nucleus;Y represents OR.sup.4 or NR.sup.5 R.sup.6 or CN;R.sup.4 represents hydrogen, substituted or unsubstituted or unsubstituted aryl, SO.sub.2 R.sup.7, COR.sup.7, CSR.sup.7, POR.sup.7 R.sup.8 ;R.sup.5 and R.sup.6 each independently has one of the significances given to R.sup.4 or represents substituted or unsubstituted amino, or R.sup.5 and R.sup.6 together represent the necessary atoms to close a heterocyclic nucleus or substituted heterocyclic nucleus, including a heterocyclic nucleus with an aliphatic or aromatic ring fused-on;R.sup.7 and R.sup.Type: GrantFiled: June 4, 1991Date of Patent: August 25, 1992Assignee: Agfa-Gevaert, N.V.Inventor: Luc J. Vanmaele
-
Patent number: 5126481Abstract: The preparation is described of compounds of the structure ##STR1## in which the substituents have the meanings indicated in the description. The compounds, which are in part new, are used as intermediate products for dyestuffs.Type: GrantFiled: April 26, 1991Date of Patent: June 30, 1992Assignee: Bayer AktiengesellschaftInventors: Karl J. Herd, Wolfgang Harms
-
Patent number: 5120364Abstract: The present invention relates to perfluoroalkyl substituted sulfates and salts thereof of the formulas(R.sub.f X CH.sub.2).sub.x C(CH.sub.2 OH).sub.y (CH.sub.2 OSO.sub.3 -M+).sub.z (I)or(R.sub.f E X CH.sub.2).sub.x C(CH.sub.2 OH).sub.y (CH.sub.2 OSO.sub.3 -M+).sub.z(II)wherein R.sub.f is a straight or branched chain perfluoroalkyl of 1 to 18 carbon atoms or said perfluoroalkyl substituted by perfluoroalkoxy of 2 to 6 carbon atoms,E is branched or straight chain alkylene of 1 to 10 carbon atoms or said alkylene interrupted by one to three groups selected from the group consisting of --NR--, --O--, --S--, --SO.sub.2 --, --COO--, --OOC--, --CONR--, --NRCO--, --SO.sub.2 NR-- and NRSO.sub.2 -- or terminated at the R.sub.f end with --CONR-- or --SO.sub.2 NR--, where R.sub.f is attached to the carbon or sulfur atom, and for formula II, X is --S--, --O--, --SO.sub.2 --, or --NR--, and for formula I, X is --CONR-- or --SO.sub.2 NR--, where R.sub.Type: GrantFiled: October 10, 1990Date of Patent: June 9, 1992Assignee: Ciba-Geigy CorporationInventors: Athanasios Karydas, Yung Loh
-
Patent number: 5066675Abstract: There are described new phenylacetic acid derivatives of general formula I ##STR1## in which R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 have the meanings given in the description, processes for their preparation and insecticidal and acaricidal compositions containing these compounds.Type: GrantFiled: August 31, 1990Date of Patent: November 19, 1991Assignee: Schering AktiengesellschaftInventors: Ulrich Buhmann, Hartmut Joppien, Dietrich Baumert
-
Patent number: 4983630Abstract: There are provided new 2,2-difluorocyclopropylethane derivatives of general formula I ##STR1## in which A, B and R.sup.1-5 have the meanings given in the description and processes for their preparation. The compounds of the invention can be used as pesticides, especially against insects and mites.Type: GrantFiled: November 28, 1988Date of Patent: January 8, 1991Assignee: Schering AktiengesellschaftInventors: Peter Wegner, Hartmut Joppien, Gunter Homberger, Arnim Kohn
-
Patent number: 4931579Abstract: Indicators for the detection of thio groups are disclosed together with processes for the preparation of such indicators.Type: GrantFiled: November 7, 1989Date of Patent: June 5, 1990Assignee: Miles Inc.Inventors: Holger Heidenreich, Klaus Wehling
-
Patent number: 4898944Abstract: Precursors for the preparation of fiber-reactive triphendioxazine dyestuffs correspond to the general formulas: ##STR1## in which Y' is a vinyl, a beta-hydroxyethyl or an ethyl group which contains in the beta-position a substituent which can be eliminated by an alkali;T is an optionally substituted alkyl (e.g.Type: GrantFiled: October 27, 1988Date of Patent: February 6, 1990Assignee: Hoechst AktiengesellschaftInventors: Gunther Schwaiger, Hartmut Springer, Walter Helmling
-
Patent number: 4864045Abstract: Aminoethyl hydrogen sulfate is produced under acidic conditions by reating ammonium bisulfate or ammonium sulfate with an ethylene compound represented by either of the formulae: ##STR1## where A represents C.dbd.C or C.dbd.S.Type: GrantFiled: October 2, 1986Date of Patent: September 5, 1989Inventors: Michael E. Ford, Thomas A. Johnson
-
Patent number: 4864052Abstract: A 2,2-dimethylcyclopropanecarboxylic acid derivative having the formula: ##STR1## wherein R.sup.1 is an alkyl group or an aryl group, R.sup.2 is a hydrogen atom, an acyl group, a sulfonyl group or an alkyl group, and each of X.sup.1 and X.sup.2 is a halogen atom.Type: GrantFiled: April 14, 1988Date of Patent: September 5, 1989Assignee: Sagami Chemical Research CenterInventors: Tamejiro Hiyama, Makoto Fujita
-
Patent number: 4826876Abstract: This invention relates to chemical compounds which have selective thyromimetic activity. A compound of this invention is 3,5-dibromo-3'-[6-oxo-3(1H)-pyridazinyl-methyl]-thyronine.Type: GrantFiled: December 21, 1987Date of Patent: May 2, 1989Assignee: Smith Kline & French Laboratories LimitedInventors: David Ellis, John C. Emmett, Anthony H. Underwood, Paul D. Leeson
-
Patent number: 4786728Abstract: Triphendioxazine compounds with properties of fiber-reactive dyestuffs corresponding to the general formula ##STR1## in which T is an optionally substituted alkyl group with 1 to 6 carbon atoms, excluding a radical of the group Y defined below, it also being possible for the alkyl group to be interrupted by hetero atoms, or is an optionally substituted aryl group,B is an oxygen or sulfur atom or an amino group,W is a divalent, optionally substituted aliphatic, cycloaliphatic, araliphatic or aromatic-carbocyclic radical or a benzotriazole radical combined with one of these radicals, it being possible for the aliphatic radicals to be interrupted by hetero groups and/or for aliphatic and aryl radicals to be bonded to one another by a hetero group,R is hydrogen, alkyl with 1 to 6 carbon atoms, alkoxy with 1 to 5 carbon atoms, halogen, carboxy or sulfo,X.sup.Type: GrantFiled: September 18, 1986Date of Patent: November 22, 1988Assignee: Hoechst AktiengesellschaftInventors: Gunther Schwaiger, Hartmut Springer, Walter Helmling
-
Patent number: 4723029Abstract: This invention relates to organic acid-substituted guanidine compounds. Also disclosed are methods for preparing the compounds, compositions containing them, and methods for their use as anthelmintics.Type: GrantFiled: September 23, 1983Date of Patent: February 2, 1988Assignee: Schering CorporationInventors: Dhiru B. Vashi, Jeffrey N. Clark, Neil A. Lindo
-
Patent number: 4701447Abstract: This invention relates to organic acid-substituted guanidine compounds. Also disclosed are methods for preparing the compounds, compositions containing them, and methods for their use as anthelmintics.Type: GrantFiled: September 23, 1983Date of Patent: October 20, 1987Assignee: Schering CorporationInventors: Dhiru B. Vashi, Jeffrey N. Clark, Neil A. Lindo
-
Patent number: 4659855Abstract: Certain novel aryl sulfonyl fluorides, their preparation, and their use in inhibiting serine proteases with chymotrypsin-like and elastase-like specificity.Type: GrantFiled: May 9, 1983Date of Patent: April 21, 1987Assignee: Georgia Tech Research CorporationInventor: James C. Powers
-
Patent number: 4597911Abstract: Sulfuric acid esters of aminoalcohols are produced by reacting an amino alcohol with ammonium bisulfate or ammonium sulfate under acidic conditions. A representative sulfuric acid ester of an aliphatic amino alcohol is aminoethyl hydrogen sulfate.Type: GrantFiled: December 14, 1983Date of Patent: July 1, 1986Assignee: Air Products and Chemicals, Inc.Inventors: Michael E. Ford, Thomas A. Johnson
-
Patent number: 4587263Abstract: New aminosulfonic acids of the general formula I ##STR1## wherein n represents the figures 4, 5, or 6, prepared according to previously known processes and characterized by very good tolerance and valuable cardiovascular properties, serve for the therapy of dysrhythmia and are superior to procaine.Type: GrantFiled: July 26, 1984Date of Patent: May 6, 1986Assignee: Warner-Lambert CompanyInventors: Gerhard Satzinger, Johannes Hartenstein, Edgar Fritschi, Wolf-Dieter Vigelius