Isonitriles (i.e., Compounds Having An Isonitrile Group, Usually Represented As -n=c, Bonded Directly To Carbon, Which Carbon May Be Single Bonded To Any Atom But May Be Multiple Bonded Only To Carbon) Patents (Class 558/302)
  • Patent number: 11279670
    Abstract: Provided is a process for separating an organic isocyanate prepared by reacting an organic amine with a stoichiometric excess of phosgene in the gas phase from the gaseous crude product obtained in the reaction, the process comprising the steps of (i) at least partially condensing the crude product stream containing at least the isocyanate, hydrogen chloride and unconverted phosgene by contacting with at least one liquid stream containing at least one quench liquid in a first separation apparatus to obtain a liquid stream containing at least some of the quench liquid and some of the isocyanate and a gas stream containing at least hydrogen chloride, evaporated quench liquid and phosgene, (ii) discharging the liquid stream obtained in step (i) via a first liquid outlet and of the gas stream obtained in (i) via a first gas conduit and (iii) at least partially condensing and/or absorbing the gas stream discharged in step (ii) through the first gas conduit, wherein that the at least partial condensation and/or abs
    Type: Grant
    Filed: January 12, 2021
    Date of Patent: March 22, 2022
    Assignee: Covestro Deutschland AG
    Inventors: Manfred Kobylka, Michael Merkel, Dominik Duerig, Bernhard Seidel
  • Patent number: 10227294
    Abstract: The invention relates to a method for preparing an aromatic polyisocyanate in an isocyanate plant comprising a reaction section for a phosgenation reaction, wherein a primary aromatic amine is reacted with phosgene compounds in a reaction section to obtain an isocyanate comprising reaction product and wherein CO2 concentration in the gases coming from the reaction section is measured and analyzed, and wherein the conditions in the phosgenation reaction are adjusted in case the CO2 concentration in the gases coming from the reaction section is higher than a background CO2 concentration.
    Type: Grant
    Filed: September 28, 2016
    Date of Patent: March 12, 2019
    Assignee: HUNTSMAN INTERNATIONAL LLC
    Inventors: Peter Muller, Robert Henry Carr
  • Patent number: 8981043
    Abstract: The present invention related to a method of manufacturing a polycarbonate including the process of copolymerizing epoxide compound and CO2 using cobalt(III) or chromium(III), where the ligands contains at least 3 ammonium cations, central metal has formal ?1 charge, and conjugated anions of the two cationic ammonium groups are acid-base homoconjugation, as catalyst. According to the present invention, the initial induction time can be reduced when the said polycarbonate is manufactured and it is possible to improve the activity of the catalyst and the molecular weight of the obtained polymer.
    Type: Grant
    Filed: September 12, 2012
    Date of Patent: March 17, 2015
    Assignee: SK Innovation Co., Ltd.
    Inventors: Jisu Jeong, Sujith Sudevan, Myungahn Ok, Jieun Yoo, BunYeoul Lee, SungJae Na
  • Publication number: 20150011627
    Abstract: The present invention provides triterpenoids produced from natural compounds such as oleanolic acid, ursolic acid, betulinic acid, and hederagenin.
    Type: Application
    Filed: September 25, 2014
    Publication date: January 8, 2015
    Applicant: Trustees of Dartmouth College
    Inventors: Gordon W. Gribble, Liangfeng Fu, Michael B. Sporn, Karen T. Liby
  • Publication number: 20140341798
    Abstract: A method of reacting amine compounds with halons and perhalogenated compounds, resulting in the conversion of these ozone-depleting species into non-volatile salts and a variety of other amine derivatives is disclosed.
    Type: Application
    Filed: March 18, 2014
    Publication date: November 20, 2014
    Inventor: Dru L. DeLaet
  • Publication number: 20140322304
    Abstract: Anti-cancer compositions and methods are described herein. In particular, compositions including one or more of leelamine, a leelamine derivative, abietylamine, an abietylamine derivative, and an abietic acid derivative are described. Methods for treatment of pathological conditions particularly cancer, in a subject using one or more of leelamine, a leelamine derivative, abietylamine, an abietylamine derivative, and an abietic acid derivative are described herein.
    Type: Application
    Filed: July 10, 2014
    Publication date: October 30, 2014
    Inventors: Gavin P. Robertson, Raghavendra Gowda Chandagalu D., Subbarao V. Madhunapantula, Gajanan S. Inamdar, Omer F. Kuzu
  • Publication number: 20140213788
    Abstract: The present invention relates to a process for the preparation of a compound of the general Formula (I), comprising: a) reacting a compound of the general Formula (II) with a compound of the Formula III R2COOH and a compound of the general Formula IV R3NC under such conditions that compound I is formed, wherein R1 represents a substituted or unsubstituted alkyl, alkenyl, alkynyl, aromatic or non-aromatic, mono-, di- or tricyclic, or heterocyclic structure, and R2 represents a substituted or unsubstituted alkyl, alkenyl, alkynyl, aromatic or non-aromatic, mono-, di- or tricyclic, or heterocyclic structure, and R3 represents a substituted or unsubstituted alkyl, alkenyl, or alkynyl structure. In further aspect the subject invention relates to the use of the the obtained products as intermediates for various peptidomimetics, and preferably as a building block in a convergent synthesis of prolyl dipeptide structures.
    Type: Application
    Filed: March 28, 2014
    Publication date: July 31, 2014
    Applicant: Vereniging voor Christelijk hoger onderwijs, wetenschappelijk onderzoek en patiëntenzorg
    Inventors: Eelco RUIJTER, Romano ORRU, Anass ZNABET, Marloes POLAK, Nicholas TURNER
  • Patent number: 8765235
    Abstract: Provided is a novel polymerizable azomethine compound which has a high ?n and is colorless. The compound is represented by the formula (I). P1 and P2 each are a polymerizable group; m1 and m2 each are an integer of from 1 to 10; R1 and R2 each are an alkyl group having from 1 to 4 carbon atoms, an alkoxy group having from 1 to 4 carbon atoms, an alkoxycarbonyl group having from 2 to 5 carbon atoms, an acyloxy group having from 2 to 5 carbon atoms, an acyl group having from 2 to 4 carbon atoms, an amide group having from 2 to 5 carbon atoms, a cyano group or a halogen atom; n1 and n2 each are an integer of from 0 to 4; R3 is a hydrogen atom, or an alkyl group having from 1 to 4 carbon atoms; Z1 and L1 each are a predetermined divalent group; n is 0, 1 or 2.
    Type: Grant
    Filed: December 17, 2012
    Date of Patent: July 1, 2014
    Assignee: FUJIFILM Corporation
    Inventors: Masatoshi Mizumura, Shunya Katoh, Yasuhiro Ishiwata, Masaomi Kimura
  • Patent number: 8765991
    Abstract: The invention relates to a process for the preparation of isocyanates in a system network comprising an isocyanate production plant, a chlorine production plant and a phosgene production plant, in which carbon dioxide formed as a by-product is partially to completely condensed out with the gaseous chlorine formed in the chlorine production plant and enters into the phosgene preparation process and, after the preparation of phosgene, the predominant part of the carbon dioxide formed is thereby sluiced out of the system network in gaseous form.
    Type: Grant
    Filed: November 30, 2012
    Date of Patent: July 1, 2014
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Jürgen Kintrup, Peter Lehner, Eric Jakobs, Alfred Soppe, Knud Werner
  • Patent number: 8703987
    Abstract: The present invention relates to new synthetic methods for preparing 2-methoxyisobutylisonitrile and metal isonitrile complexes, such as tetrakis(2-methoxyisobutylisonitrile)copper(I) tetrafluoroborate, which are used in the preparation of technetium (99mTc) Sestamibi, and novel intermediate compounds useful in such methods.
    Type: Grant
    Filed: July 17, 2009
    Date of Patent: April 22, 2014
    Assignee: Draximage Limited
    Inventor: Pierre Morel
  • Patent number: 8686145
    Abstract: The present invention relates to a process for the preparation of a compound of the general Formula (I), comprising: a) reacting a compound of the general Formula (II) with a compound of the Formula III R2COOH and a compound of the general Formula IV R3NC under such conditions that compound I is formed, wherein R1 represents a substituted or unsubstituted alkyl, alkenyl, alkynyl, aromatic or non-aromatic, mono-, di- or tricyclic, or heterocyclic structure, and R2 represents a substituted or unsubstituted alkyl, alkenyl, alkynyl, aromatic or non-aromatic, mono-, di- or tricyclic, or heterocyclic structure, and R3 represents a substituted or unsubstituted alkyl, alkenyl, or alkynyl structure. In further aspect the subject invention relates to the use of the obtained products as intermediates for various peptidomimetics, and preferably as a building block in a convergent synthesis of prolyl dipeptide structures.
    Type: Grant
    Filed: September 16, 2010
    Date of Patent: April 1, 2014
    Assignee: Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek en Patientenzorg C/O Technology Transfer Officer VU & Vumc
    Inventors: Eelco Ruijter, Romano Orru, Anass Znabet, Marloes Polak, Nicholas Turner
  • Patent number: 8669398
    Abstract: The invention relates to novel O-dialkylamino-isoureas and polymerizable compositions comprising these O-dialkylamino-isoureas of compounds of the general formula (I). The invention further relates to the use of O-dialkylamino-isoureas as polymerization initiators, especially to prepare coatings or for controlled degradation of polyolefins.
    Type: Grant
    Filed: December 28, 2009
    Date of Patent: March 11, 2014
    Assignee: BASF SE
    Inventors: Peter Nesvadba, Lucienne Bugnon Folger, Antoine Carroy, Marc Faller
  • Patent number: 8563763
    Abstract: The present invention relates to isonitrile compounds, methods of synthesis, and uses in a variety of fields. In one aspect, the present invention includes sulfinyl methyl isonitriles and methods for their preparation. In another aspect, the present invention includes the use of sulfinyl methyl isonitriles to prepare various other isonitrile compounds and derivatives thereof. In yet another aspect, the present invention includes a relatively simple and routine synthesis of sulfinyl methyl isonitrile compounds, other isonitrile compounds and derivatives thereof.
    Type: Grant
    Filed: March 14, 2012
    Date of Patent: October 22, 2013
    Assignee: Duquesne University of the Holy Ghost
    Inventors: Fraser Ferguson Fleming, Bhaskar Reddy Pitta
  • Patent number: 8481755
    Abstract: This invention relates to novel compounds with ester linkage(s) capped with either electron deficient olefinic linkage(s) or group(s) or reactive functional groups (termed herein as “active methylene reagents”), and curable compositions prepared therefrom.
    Type: Grant
    Filed: April 23, 2010
    Date of Patent: July 9, 2013
    Assignee: Henkel Ireland Ltd.
    Inventors: Ciaran B. McArdle, Ligang Zhao, Stefano Gherardi, Kevin Murnaghan
  • Publication number: 20130144081
    Abstract: The invention relates to a process for the preparation of isocyanates in a system network comprising an isocyanate production plant, a chlorine production plant and a phosgene production plant, in which carbon dioxide formed as a by-product is partially to completely condensed out with the gaseous chlorine formed in the chlorine production plant and enters into the phosgene preparation process and, after the preparation of phosgene, the predominant part of the carbon dioxide formed is thereby sluiced out of the system network in gaseous form.
    Type: Application
    Filed: November 30, 2012
    Publication date: June 6, 2013
    Applicant: Bayer Intellectual Property GmbH
    Inventor: Bayer Intellectual Property GmbH
  • Publication number: 20130090428
    Abstract: A coating agent for hand painting application obtained by a urethane resin composition obtained by allowing a main agent (A) and a curing agent (B) to react. The main agent (A) containing: an isocyanate group-terminated prepolymer (b) having diphenylmethane diisocyanate bound to the termini of a polyol component (a) containing a long chain polyol (e) which contains at least a polyhydroxy functional product such as a trihydroxy or higher-hydroxy functional product and having a molecular weight of 200 or greater; and unbound diphenylmethane diisocyanate(c). The curing agent (B) containing: a crosslinking agent (g) obtained by a short chain polyol (f) having a molecular weight of less than 200; and a long chain polyol (h) having a molecular weight of 200 or greater.
    Type: Application
    Filed: October 7, 2010
    Publication date: April 11, 2013
    Applicant: DYFLEX CORPORATION
    Inventors: Daisuke Tanihara, Noriyoshi Yano
  • Publication number: 20120330015
    Abstract: The present invention relates to a process for the preparation of a compound of the general Formula (I), comprising: a) reacting a compound of the general Formula (II) with a compound of the Formula III R2COOH and a compound of the general Formula IV R3NC under such conditions that compound I is formed, wherein R1 represents a substituted or unsubstituted alkyl, alkenyl, alkynyl, aromatic or non-aromatic, mono-, di- or tricyclic, or heterocyclic structure, and R2 represents a substituted or unsubstituted alkyl, alkenyl, alkynyl, aromatic or non-aromatic, mono-, di- or tricyclic, or heterocyclic structure, and R3 represents a substituted or unsubstituted alkyl, alkenyl, or alkynyl structure. In further aspect the subject invention relates to the use of the obtained products as intermediates for various peptidomimetics, and preferably as a building block in a convergent synthesis of prolyl dipeptide structures.
    Type: Application
    Filed: September 16, 2010
    Publication date: December 27, 2012
    Applicant: Vereniging voor Christelijk hoger onderwijs, wetenschappelijk onderzoek en patientenzorg
    Inventors: Eelco Ruijter, Romano Orru, Anass Znabet, Marloes Polak, Nicholas Turner
  • Publication number: 20120259124
    Abstract: The present invention relates to isonitrile compounds, methods of synthesis, and uses in a variety of fields. In one aspect, the present invention includes sulfinyl methyl isonitriles and methods for their preparation. In another aspect, the present invention includes the use of sulfinyl methyl isonitriles to prepare various other isonitrile compounds and derivatives thereof. In yet another aspect, the present invention includes a relatively simple and routine synthesis of sulfinyl methyl isonitrile compounds, other isonitrile compounds and derivatives thereof.
    Type: Application
    Filed: March 14, 2012
    Publication date: October 11, 2012
    Applicant: Duquesne University of the Holy Ghost
    Inventors: FRASER FERGUSON FLEMING, Bhaskar Reddy Pitta
  • Publication number: 20120259137
    Abstract: The present invention relates to isonitrile compounds, methods of synthesis, and uses in a variety of fields. In one aspect, the present invention includes sulfinyl methyl isonitriles and methods for their preparation. In another aspect, the present invention includes the use of sulfinyl methyl isonitriles to prepare various other isonitrile compounds and derivatives thereof. In yet another aspect, the present invention includes a relatively simple and routine synthesis of sulfinyl methyl isonitrile compounds, other isonitrile compounds and derivatives thereof.
    Type: Application
    Filed: April 5, 2011
    Publication date: October 11, 2012
    Applicant: Duquesne University of the Holy Ghost
    Inventors: FRASER FERGUSON FLEMING, Bhaskar Reddy Pitta
  • Patent number: 8269032
    Abstract: The present invention relates to isonitrile compounds, methods of synthesis, and uses in a variety of fields. In one aspect, the present invention includes sulfinyl methyl isonitriles and methods for their preparation. In another aspect, the present invention includes the use of sulfinyl methyl isonitriles to prepare various other isonitrile compounds and derivatives thereof. In yet another aspect, the present invention includes a relatively simple and routine synthesis of sulfinyl methyl isonitrile compounds, other isonitrile compounds and derivatives thereof.
    Type: Grant
    Filed: April 5, 2011
    Date of Patent: September 18, 2012
    Assignee: Duquesne University of the Holy Ghost
    Inventors: Fraser Ferguson Fleming, Bhaskar Reddy Pitta
  • Publication number: 20120108819
    Abstract: Described are N-heterocyclic carbene complexes of the formula I, where n is 0 or 1, M is a metal atom containing group, R1 is selected from hydrogen alkyl, cycloalkyl, heterocycloalkyl, aryl and hetaryl, R2 is selected from hydrogen, alkyl, cycloalkyl, heterocycloalkyl, aryl and hetaryl, wherein R1 and R2 do not both stand for hydrogen. Furthermore, also described are methods for their preparation and their use as catalysts employed in a C—C, C—O, C—N or C—H bond formation reaction.
    Type: Application
    Filed: October 28, 2011
    Publication date: May 3, 2012
    Applicant: BASF SE
    Inventors: A. Stephen K. Hashmi, Christian Lothschütz
  • Patent number: 8129558
    Abstract: The present invention relates to 2,5-di-substituted-4-naphthyloxy-substituted-phenyl-amidine derivatives of formula (I) wherein the substituents are as in the description, their process of preparation, their use as fungicide or insecticide active agents, particularly in the form of fungicide or insecticide compositions, and methods for the control of phytopathogenic fungi or damaging insects, notably of plants, using these compounds or compositions.
    Type: Grant
    Filed: September 12, 2006
    Date of Patent: March 6, 2012
    Assignee: Bayer Cropscience AG
    Inventors: Klaus Kunz, Jörg Greul, Oliver Guth, Benoît Hartmann, Kerstin Ilg, Wahed Moradi, Thomas Seitz, Peter Dahmen, Arnd Voerste, Ulrike Wachendorff-Neumann, Ralf Dunkel, Ronald Ebbert, Eva-Maria Franken
  • Publication number: 20110236308
    Abstract: The present invention relates generally to chelation compounds, radionuclide metal chelate compounds, i.e., complexes, and radiolabeled targeting moieties, i.e., conjugates, formed therefrom, and methods of using these compounds, complexes and conjugates for diagnostic and therapeutic purposes. This invention is more particularly related to aryl bidentate isonitrile metal complexes generated by a chemical interaction of a metal salt oxide or weak complex of the metal with aryl isonitrile bidentate ligands.
    Type: Application
    Filed: April 17, 2007
    Publication date: September 29, 2011
    Applicant: The General Hospital Corporation
    Inventors: David R. Elmaleh, Timothy M. Shoup, Alan J. Fischman, Bhaskar C. Das
  • Publication number: 20110159304
    Abstract: Disclosed are a composition for inhibiting a proliferation of sulphate reducing bacteria comprising at least one of 1,2-benzisothiazol-3(2H)-one, irgasan, benzyl-2-bromoacetate, 2,2-dibromo-2-cyanoacetamide, and 2-bromo-2-nitropropan-1,3-diol as effective ingredients; a method for inhibiting the proliferation of sulphate reducing bacteria comprising the step of including a sufficient amount for inhibiting the proliferation of sulphate reducing bacteria of at least one of 1,2-benzisothiazol-3(2H)-one, irgasan, benzyl-2-bromoacetate, 2,2-dibromo-2-cyanoacetamide, and 2-bromo-2-nitropropan-1,3-diol in a corrosion sensitive material or degradation sensitive material; a sheet comprising the composition; and a steel plate to which the composition is applied.
    Type: Application
    Filed: June 2, 2010
    Publication date: June 30, 2011
    Applicant: KOREA GAS CORPORATION
    Inventors: Hong Seok Song, Young Geun Kim, Keun Chang Ryu, Young Min Baek, Young Hyo Chang
  • Publication number: 20110130540
    Abstract: There are disclosed high yield and high productivity processes for preparing 3-hydroxyglutaronitrile by reacting allyl cyanide epoxide with a basic aqueous solution of a cyanide source.
    Type: Application
    Filed: August 14, 2008
    Publication date: June 2, 2011
    Applicant: E.I. DU PONT DE NEMOURS AND COMPANY
    Inventor: Jelena Cirakovic
  • Publication number: 20110082302
    Abstract: Disclosed are a process suited to large scale synthesis with high yield for producing oseltamivir phosphate, in which a preparation of oseltamivir phosphate which is highly safe as a pharmaceutical product can be produced, and an intermediate compound for producing oseltamivir phosphate. In this production process, an intermediate compound represented by general formula (V) is synthesized by employing Michael reaction/Michael reaction/Horner-Wadsworth-Emmons reaction, and oseltamivir phosphate is produced by converting the substituent groups in this intermediate compound.
    Type: Application
    Filed: May 28, 2009
    Publication date: April 7, 2011
    Inventors: Yujiro Hayashi, Hayato Ishikawa
  • Publication number: 20110065905
    Abstract: A ligand of Formula (I) is provided: wherein A4 represents a hydrogen atom, a nitro group, an amino group, a thiocyanato group, or —Z—Y, in which Z is a divalent linking group and Y is a group derived from a biocompatible molecule, with the proviso that when X is methylene, A4 cannot be a hydrogen atom or a nitro group. A metal complex having the ligand is also provided and is useful as a blood pool contrast agent or a targeting contrast agent.
    Type: Application
    Filed: February 8, 2010
    Publication date: March 17, 2011
    Applicant: National Chiao Tung University
    Inventors: Yun-Ming Wang, Ting-Jung Chen
  • Publication number: 20100292481
    Abstract: A method for producing a conjugated aromatic compound comprising reacting an aromatic compound (A) wherein one or two leaving groups are bonded to an aromatic ring with an aromatic compound (A) having the same structure as that of the above-mentioned aromatic compound (A) or an aromatic compound (B) being structurally different from the above-mentioned aromatic compound (A) and having one or two leaving groups bonded to an aromatic ring, in the presence of a nickel compound, a ligand, a manganese salt and a metal reducing agent.
    Type: Application
    Filed: December 17, 2008
    Publication date: November 18, 2010
    Inventors: Seiji Oda, Takashi Kamikawa
  • Publication number: 20100274023
    Abstract: The present invention provides new intermediate compounds enabling the preparation of N-meso substituted cyanine, merocyanine or oxonole dyes wherein the N-meso substituent comprises electron withdrawing groups and wherein such N-meso substituents are introduced at the intermediate level. These intermediates enable the formation of dyes having in the meso-position N-substituents comprising electron withdrawing groups without the need for further derivatization of the meso-substituent at the dye level.
    Type: Application
    Filed: December 18, 2008
    Publication date: October 28, 2010
    Applicant: Agfa Graphics NV
    Inventors: Paul Callant, Jos Louwet
  • Publication number: 20100273939
    Abstract: The present invention discloses polyurethane dispersions based on aliphatic isocyanates which form hard coatings wherein the coatings also have good solvent resistant properties. The enhanced properties of the coatings are achieved by including from 1 to 8 weight percent of a high functional polyol in the polyol formulation for producing the dispersions.
    Type: Application
    Filed: December 9, 2008
    Publication date: October 28, 2010
    Inventors: Friederike Stollmaier, Bindushree Radhakrishnan, Stefano Carlo E Grassini, Jean-Luc Roser, Kenneth W. Skaggs
  • Publication number: 20100199888
    Abstract: This invention relates to novel compounds with ester linkage(s) capped with either electron deficient olefinic linkage(s) or group(s) or reactive functional groups (termed herein as “active methylene reagents”), and curable compositions prepared therefrom.
    Type: Application
    Filed: April 23, 2010
    Publication date: August 12, 2010
    Applicant: Loctite (R&D) Limited
    Inventors: Ciaran B. McArdle, Ligang Zhao, Stefano Gherardi, Kevin Murnaghan
  • Publication number: 20100029896
    Abstract: Provided are a complex prepared from ammonium salt-containing ligands and having such an equilibrium structural formula that the metal center takes a negative charge of 2 or higher, and a method for preparing polycarbonate via copolymerization of an epoxide compound and carbon dioxide using the complex as a catalyst. When the complex is used as a catalyst for copolymerizing an epoxide compound and carbon dioxide, it shows high activity and high selectivity and provides high-molecular weight polycarbonate, and thus easily applicable to commercial processes. In addition, after forming polycarbonate via carbon dioxide/epoxide copolymerization using the complex as a catalyst, the catalyst may be separately recovered from the copolymer.
    Type: Application
    Filed: July 29, 2009
    Publication date: February 4, 2010
    Inventors: Myungahn Ok, Jisu Jeong, Bun Yeoul Lee, Sujith S., Anish Cyriac, JaeKi Min, JongEon Seong
  • Publication number: 20100016625
    Abstract: The invention relates to a process for preparing an amino nitrile mixture comprising aminoacetonitrile (AAN) and from 5 to 70% by weight of iminodiacetonitrile (IDAN), which comprises heating crude AAN which is largely free of formaldehyde cyanohydrin (FACH-free) at a temperature of from 50 to 150° C.
    Type: Application
    Filed: February 28, 2008
    Publication date: January 21, 2010
    Applicant: BASF SE
    Inventors: Alfred Oftring, Kirsten Dahmen, Thilo Hahn, Randolf Hugo, Katrin Baumann, Johann-Peter Melder
  • Publication number: 20100010250
    Abstract: The present invention relates to new synthetic methods for preparing 2-methoxyisobutylisonitrile and metal isonitrile complexes, such as tetrakis(2-methoxyisobutylisonitrile)copper(I) tetrafluoroborate, which are used in the preparation of technetium (99mTc) Sestamibi, and novel intermediate compounds useful in such methods.
    Type: Application
    Filed: July 17, 2009
    Publication date: January 14, 2010
    Applicant: Draximage Limited
    Inventor: Pierre Morel
  • Publication number: 20090294730
    Abstract: A polymerizable composition comprising a bifunctional (meth)acrylate compound represented by the following general formula (1) and a monofunctional (meth)acrylate compound represented by the general formula (2): R1 and R2 each=a hydrogen atom, methyl group, or halogen atom; A1, A2, A3 each=a benzene, cyclohexane, cyclohexene, naphthalene, decahydronaphthalene, tetrahydronaphthalene, or phenanthrene ring; rings may be substituted with 1-8 carbon atom alkyl group, 1-8 carbon atom alkoxy group, a halogen atom, or a cyano group; at least one of A1, A2, and A3 comprises a substituent; —CH? may be replaced by —N?, and —CH2— may be replaced by —S— or —O—: L1, L2, L3 each=a single bond, —COO—, —OCO—, —(CH2)p—, —CH?CH—, —(CH2)qO—, —CH?CHCH2O—, —CH?C—, —(CH2)2COO—, or —CF?CF—; n=integer 0-3; and, when n?2, L3 and A3 may be the same or different; p and q each=an integer 1-8:
    Type: Application
    Filed: March 14, 2007
    Publication date: December 3, 2009
    Applicant: ADEKA CORPORATION
    Inventors: Masatomi Irisawa, Ken Matsumoto
  • Patent number: 7563920
    Abstract: The present invention relates to new synthetic methods for preparing 2-methoxyisobutylisonitrile and metal isonitrile complexes, such as tetrakis(2-methoxyisobutylisonitrile)copper(I) tetrafluroroborate, which are used in the preparation of technetium (99mTc) Sestamibi, and novel intermediate compounds useful in such methods.
    Type: Grant
    Filed: May 29, 2007
    Date of Patent: July 21, 2009
    Assignee: Draximage Limited
    Inventor: Pierre Morel
  • Patent number: 7232583
    Abstract: A method for preparing an isothiocyanate product from a cruciferous plant material is disclosed which is capable of stably preparing an isothiocyanate product in a sufficient amount in a high yield by subjecting a natural cruciferous plant material such as wasabi, horseradish, watercress or the like as a starting material to sufficient enzymatic reaction and, in particular, which is capable of stably preparing an isothiocyanate product containing no pungent ingredient in a sufficient amount in a high yield from a natural cruciferous plant material. A cruciferous plant material consisting of pulverized wasabi and/or horseradish was maintained at a temperature of ?3° C. to 50°0 C.
    Type: Grant
    Filed: September 5, 2002
    Date of Patent: June 19, 2007
    Assignee: Kinjirushi Co., Ltd.
    Inventors: Mitsuyoshi Murata, Isao H. C. Okunishi, Yuji Ugai, Hakusei Kobayashi
  • Patent number: 6924385
    Abstract: The invention relates to a method for synthesis of aliphatic isocyanates from aromatic isocyanates in substantially 3 stages. In particular, the invention relates to a method for synthesis of bis{4-isocyanatocyclohexyl}methane (H12MDI) from bis{4-isocyanatophenyl}methane (MDI). More especially, the invention relates to a method for synthesis of H12MDI with a trans-trans isomer content of <30%, preferably of <20%, particularly preferably of 5 to 15%.
    Type: Grant
    Filed: December 31, 2002
    Date of Patent: August 2, 2005
    Assignee: Degussa AG
    Inventors: Christian Lettmann, Stephan Kohlstruk, Guido Stochniol, Emmanouil Spyrou
  • Patent number: 6509490
    Abstract: In a method for separating isophthalonitrile from a gas produced by causing m-xylene to react with ammonia and oxygen-containing gas in the presence of a catalyst, the gas is brought into contact with an organic solvent having a boiling point lower than that of isophthalonitrile; a liquid in which isophthalonitrile is trapped in a trapping step is distilled, to thereby recover isophthalonitrile and the organic solvent from the top of the column and separate at the bottom of the column impurities having boiling points higher than that of isophthalonitrile; and the organic solvent is recovered from the top of the rectification column and liquefied isophthalonitrile of high purity is recovered at the bottom of the column.
    Type: Grant
    Filed: September 17, 2001
    Date of Patent: January 21, 2003
    Assignee: Mitsubishi Gas Chemical Co. Inc.
    Inventors: Susumu Otsuka, Takuji Shitara, Fumisada Kosuge, Kazuhiko Amakawa
  • Patent number: 6479669
    Abstract: Disclosed are novel compounds, and methods of making the same, represented by Structural Formula II, IX or XXVII: The compounds can be used to prepare combinatorial libraries based on a multicomponent Ugi reaction.
    Type: Grant
    Filed: June 29, 1999
    Date of Patent: November 12, 2002
    Assignee: Pharm-Eco Laboratories, Inc.
    Inventors: Richard L. Gabriel, Jurjus Jurayj
  • Publication number: 20020010342
    Abstract: Disclosed are novel compounds represented by Structural Formula II, IX or XXVIII: 1
    Type: Application
    Filed: June 29, 1999
    Publication date: January 24, 2002
    Inventors: RICHARD L. GABRIEL, JURJUS JURAYJ
  • Patent number: 6191171
    Abstract: para-Aminomethylaryl carboxamides of Formula I are antagonists of VLA-4 and/or &agr;4&bgr;7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and are suitable for use in the treatment of asthma, allergies, inflammation, multiple sclerosis, and other inflammatory and autoimmune disorders.
    Type: Grant
    Filed: November 13, 1998
    Date of Patent: February 20, 2001
    Assignee: Merck & Co., Inc.
    Inventors: Stephen E. DeLaszlo, William K. Hagmann
  • Patent number: 6150343
    Abstract: The present invention provides generally a compound having the following general formula (1): ##STR1## wherein R.sup.1 and R.sup.2 are independently the same or different and are hydrogen, an alkyl group, an alkenyl group, a benzyl group, an alkynyl group, an alkoxyl group, an aryloxy group, an acyloxy group, a OC(O)OR.sup.d group, a carbamoyloxy group, a halogen, a hydroxyl group, a nitro group, a cyano group, an azido group, a formyl group, a hydrazino group, an acyl group, an amino group, --SR.sup.c, wherein, R.sup.c is hydrogen, an acyl group, an alkyl group, or an aryl group, or R.sup.1 and R.sup.2 together form a group of the formula --O(CH.sub.2).sub.n O-- wherein n represents the integer 1 or 2; R.sup.3 is H, F, a halogen atom, a nitro group, an amino group, a hydroxyl group, or a cyano id group; or R.sup.2 and R.sup.3 together form a group of the formula --O(CH.sub.2).sub.n O-- wherein n represents the integer 1 or 2; R.sup.4 is H, F, a C.sub.1-3 alkyl group, a C.sub.2-3 alkenyl group, a C.sub.
    Type: Grant
    Filed: August 29, 1997
    Date of Patent: November 21, 2000
    Assignee: University of Pittsburgh
    Inventors: Dennis P. Curran, Hubert Josien, Bom David
  • Patent number: 5847190
    Abstract: The present invention relates to dendritic, nitrogen-containing organic compounds containing at least 4 planar-chiral or axial-chiral groups, where these planar-chiral or axial-chiral groups are linked as Schiff's bases to the primary amino groups of compounds of the formula (I)(R.sup.1 R.sup.1)N--X--N(R.sup.1 R.sup.1) (I)whereR.sup.1 is (R.sup.2 R.sup.2)N--(CH.sub.2).sub.2 -- or (R.sup.2 R.sup.2)N--(CH.sub.2).sub.3 --,R.sup.2 is hydrogen or (R.sup.3 R.sup.3)N--CH.sub.2).sub.2 -- or (R.sup.3 R.sup.3)N--(CH.sub.2).sub.3 --,R.sup.3 is hydrogen or (R.sup.4 R.sup.4)N--(CH.sub.2).sub.2 -- or (R.sup.4 R.sup.4)N--(CH.sub.2).sub.3 --,R.sup.4 is hydrogen or (R.sup.5 R.sup.5)--N--(CH.sub.2).sub.2 -- or (R.sup.5 R.sup.5)N--(CH.sub.2).sub.3 --,R.sup.5 is hydrogen or (R.sup.6 R.sup.6)N--(CH.sub.2).sub.2 -- or (R.sup.6 R.sup.6)N--(CH.sub.2).sub.3 -- andR.sup.6 is hydrogen,X is an aliphatic and/or aromatic group, which may contain heteroatoms,which are suitable as catalysts for asymmetrical homogeneous catalysis.
    Type: Grant
    Filed: May 20, 1997
    Date of Patent: December 8, 1998
    Assignee: BASF Aktiengesellschaft
    Inventors: Wolfgang Paulus, Fritz Vogtle, Jorg Issberner
  • Patent number: 5585359
    Abstract: The present invention comprises analogs of the CAAX motif of the protein Ras that is modified by farnesylation in vivo. These CAAX analogs inhibit the farnesylation of Ras. Furthermore, these CAAX analogues differ from those previously described as inhibitors of Ras farnesyl transferase in that they do not have a thiol moiety. The lack of the thiol offers unique advantages in terms of improved pharmacokinetic behavior in animals, prevention of thiol-dependent chemical reactions, such as rapid autoxidation and disulfide formation with endogenous thiols, and reduced systemic toxicity. Further contained in this invention are chemotherapeutic compositions containing these farnesyl transferase inhibitors and methods for their production.
    Type: Grant
    Filed: September 29, 1994
    Date of Patent: December 17, 1996
    Assignee: Merck & Co., Inc.
    Inventors: Michael J. Breslin, S. J. deSolms, Samuel L. Graham, John H. Hutchinson, Gerald E. Stokker
  • Patent number: 5489632
    Abstract: Novel imino ether compounds, processes for their production and methods for their use are provided. These novel imino ether compounds are particularly useful as light stabilizers for polymeric compositions, particularly for lacquer coating compositions.
    Type: Grant
    Filed: July 28, 1993
    Date of Patent: February 6, 1996
    Assignee: Sandoz Ltd.
    Inventor: Lajos Avar
  • Patent number: 5466813
    Abstract: Imine dyes useful in photographic materials have the formula ##STR1## wherein R.sup.1, E.sup.1, E.sup.2, L.sup.1, L.sup.2, L.sup.3,D and m are defined as in the specification.Solid particle dispersions of dyes of formula (I) that contain at least one base-ionizable functional group such as carboxy, sulfonamido, or sulfamoyl are useful as filter dyes in photographic elements.
    Type: Grant
    Filed: July 20, 1993
    Date of Patent: November 14, 1995
    Assignee: Eastman Kodak Company
    Inventors: Donald R. Diehl, Margaret J. Helber, Hugh Williamson
  • Patent number: 5241099
    Abstract: Aminomethylene compounds of the formula ##STR1## can be prepared by reaction of C-H-acid compounds of the formula ##STR2## with salts of the formula ##STR3## in the presence of simple inorganic bases, where the radicals R.sup.1 to R.sup.4, R.sup.7, R.sup.8 and X.sup..crclbar. have the meanings given in the description.
    Type: Grant
    Filed: March 16, 1992
    Date of Patent: August 31, 1993
    Assignee: Bayer Aktiengesellschaft
    Inventors: Heinz-Ulrich Blank, Helmut Kraus
  • Patent number: 5233047
    Abstract: Hydrazide functionalized benzotrialzole and oxanilide ultraviolet absorbers (Formulas I and II) useful for stabilizing coreactive or inert polymeric compositions and novel intermediates (Formula III used to make certain types of compounds of Formula I) are disclosed and have the general formulas: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, X, Y, all substituents thereof, and n are set forth in the Summary of the Invention.
    Type: Grant
    Filed: May 1, 1991
    Date of Patent: August 3, 1993
    Assignee: Elf Atochem North America, Inc.
    Inventors: Ronald E. MacLeay, Terry N. Myers
  • Patent number: 5210097
    Abstract: A xanthocillin X monomethyl ether derivative represented by the formula (I) ##STR1## wherein R represents an alkyl group, an alkenyl group, an alkoxycarbonyl group, an aralkyl group, an alkyl group substituted with a pyridyl group or a halogen atom, an aralkyl group substituted with an alkyl group or a halogen atom, or an aroyl group, which exerts an intense effect of inhibiting the proliferation of a tumor, in particular, a solid tumor.
    Type: Grant
    Filed: May 18, 1990
    Date of Patent: May 11, 1993
    Assignee: Meiji Seika Kaisha Ltd.
    Inventors: Hiroshi Kurihara, Hiromi Watanabe, Masao Koyama, Masaji Sezaki, Tsutomu Tsuruoka, Harumi Fukuyasu, Haruo Yamamoto