Oxygen Attached Directly To The Nitrogen Of The Imidate Group By Nonionic Bonding (i.e., Ho-n=ch-o-, Wherein Substitution May Be Made For Hydrogen Only) Patents (Class 558/7)
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Patent number: 8476188Abstract: A renewable adsorbent enabling to adsorb cesium selectively and efficiently, and to reuse cesium by eluting adsorbed cesium, and its manufacturing method are provided. Polyethylene (PE)/polypropylene (PP) based non-woven fabric may be exposed with electron beam, PE/PP based non-woven fabric to which electron beam was exposed is contacted to the monomer solution containing acrylonitrile (AN), dimethyl sulfoxide (DMSO), Tween80 (polyoxyethylene sorbitan monooleate) as a surfactant, and AMP (ammonium molybdophosphate n-hydrate) as an inorganic ion exchanger, and then the inorganic ion exchanger (AMP) is supported directly by the non-ionic graft chain.Type: GrantFiled: June 4, 2012Date of Patent: July 2, 2013Assignee: Japan Atomic Energy AgencyInventors: Akio Iwanade, Noriaki Seko, Hiroyuki Hoshina, Yuji Ueki, Seiichi Saiki
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Patent number: 7705175Abstract: Provided is a method for producing an imide ether compound in high yield. The method is characterized in that a nitrile compound, an alcohol, and a hydrogen halide are continuously introduced into a flow reaction device comprising a mixer and a flow reactor, to be subjected to a reaction. Because a reaction proceeds in a ratio of 1:1 by a flow reactor, selectivity is improved and generation of by-products is decreased, and thus an imide ether compound can be efficiently produced.Type: GrantFiled: January 18, 2006Date of Patent: April 27, 2010Assignee: Nippoh Chemicals Co., Ltd.Inventors: Hitoshi Mitsui, Yuichiro Kinoshita, Kazuya Nakagawa
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Patent number: 7148239Abstract: A method of increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed to a physiological stress which induces expression of a molecular chaperon by the cell with an effective amount of a certain hydroxylamine derivative to increase the stress. Alternatively, an hydroxylamine derivative can be administrated to a cell before it is exposed to a physiological stress which induces expression of a molecular chaperon by the cell. Preferably, the cell to which an hydroxylamine derivative is administered is an eukaryotic cell. The hydroxylamine derivative corresponds to the formulae (I) or (II). The invention also provides novel hydroxylamine derivatives falling within the scope of the formulae (I) and (II) as well as pharmaceutical and/or cosmetical compositions comprising the said compounds.Type: GrantFiled: July 10, 2003Date of Patent: December 12, 2006Assignee: CytRx CorporationInventors: László Vígh, Péter Literáti Nagy, Jenó Szilbereky, László Ürögdi, Andrea Jednákovits, László Jaszlits, Katalin Bíró, Ede Márványos, Mihály Barabás, Erzsébet Hegedüs, László Korányi, Mária Kürthy, Gábor Balogh, Ibolya Horváth, Zsolt Török, Éva Udvardy, György Dormán, Dénes Medzihradszky, Bea Mézes, Eszter Kovács, Ernó Duda, Beatrix Farkas, Attila Glatz
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Patent number: 6653326Abstract: A method of increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed to a physiological stress which induces expression of a molecular chaperon by the cell with an effective amount of a certain hydroxylamine derivative to increase the stress. Alternatively; an hydroxylamine derivative can be administrated to a cell before it is exposed to a physiological stress which induces expression of a molecular chaperon by the cell. Preferably, the cell to which an hydroxylamine derivative is administered is an eukaryotic cell. The hydroxylamine derivative corresponds to the formulae (I) or (II). The invention also provides novel hydroxyl amine derivatives falling within the scope of the formulae (I) and (II) as well as pharmaceutical and/or cosmetical compositions comprising the said compounds.Type: GrantFiled: December 7, 1999Date of Patent: November 25, 2003Assignee: Biorex Research & Development Co.Inventors: László Vígh, Péter Literáti Nagy, Jenó Szilbereky, László Ürögdi, Andrea Jednákovits, László Jaszlits, Katalin Bíró, Ede Màrvànyos, Mihály Barabás, Erzsébet Hegedüs, László Korányi, Mária Kürthy, Gábor Balogh, Ibolya Horváth, Zsolt Török, Éva Udvardy, György Dormán, Dénes Medzihradszky, Bea Mézes, Eszter Kovács, Ernö Duda, Beatrix Farkas, Attila Glatz
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Patent number: 6387849Abstract: Novel hydroximic acid derivatives I and salts thereof, where X=O, S; Y=O, S; R1=H, C1-C4-alkyl, NH2, C1-C4-alkylamino or di(C1-C4-alkyl)amino; R2=C1-C3-haloalkyl; R3=H, halogen, C1-C4-alkyl; R4=H, halogen; R5=CN, halogen; R6=C1-C6-alkyl, C2-C6-alkenyl, C3-C6-alkynyl or phenyl-C1-C6-alkyl, where the phenyl ring of this group may be unsubstituted or may carry 1-3 substituents; R7=a C1-C6-alkyl, C2-C6-alkenyl, C3-C6-alkynyl or phenyl-C1-C6-alkyl, where these 4 groups may be unsubstituted or may carry 1 to 2 substituents; Use: As herbicides; for the desiccation/defoliation of plants.Type: GrantFiled: September 21, 1999Date of Patent: May 14, 2002Assignee: BASF AktiengesellschaftInventors: Olaf Menke, Gerhard Hamprecht, Markus Menges, Robert Reinhard, Peter Schäfer, Cyrill Zagar, Karl-Otto Westphalen, Ulf Misslitz, Helmut Walter
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Patent number: 6337306Abstract: Phenoxyacetic acid derivatives of the formula: wherein R1, R2, Xn and A are as defined herein, and a process for preparing the derivatives. The derivatives are used as herbicides.Type: GrantFiled: November 5, 1999Date of Patent: January 8, 2002Assignee: Rhone-Poulenc AgroInventors: Norio Sasaki, Atsushi Go, Hideshi Mukaida, Yukiko Oe
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Patent number: 5994359Abstract: 2-Iminooxyphenylacetic acid derivatives ##STR1## where the substituents and the index have the following meanings: R.sup.1 is C(CO.sub.2 CH.sub.3).dbd.NOCH.sub.3 (Ia), C(CONHCH.sub.3).dbd.NOCH.sub.3 (Ib), C(CONH.sub.2).dbd.NOCH.sub.3 (Ic), C(CO.sub.2 CH.sub.3).dbd.CHOCH.sub.3 (Id) or C(CO.sub.2 CH.sub.3).dbd.CHCH.sub.3 (Ie);R.sup.2 is cyano, nitro, halogen, alkyl, haloalkyl or alkoxy;m is 0, 1 or 2;R.sup.3 is hydrogen, cyano, hydroxyl, halogen,alkyl, haloalkyl, alkoxyalkyl, alkoxy, haloalkoxy, alkylthio, cyclopropyl, alkenyl,unsubstituted or substituted aryloxyalkyl, benzyl or benzyloxy,R.sup.4 is hydrogen, cyano,unsubstituted or substituted alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl and hetaryl;unsubstituted or substituted alkoxy, alkenyloxy, alkynyloxy, cycloalkoxy, heterocyclyloxy, aryloxy and hetaryloxy;unsubstituted or substituted arylthio and hetarylthio;--Q--C(R.sup.5).dbd.N--Y.sup.1 --R.sup.6 or --Q--O--N.dbd.CR.sup.7 R.sup.8,R.sup.3 and R.sup.Type: GrantFiled: June 25, 1998Date of Patent: November 30, 1999Assignee: BASF AktiengesellschaftInventors: Thomas Grote, Hubert Sauter, Reinhard Kirstgen, Herbert Bayer, Ruth Muller, Bernd Muller, Klaus Oberdorf, Wassilios Grammenos, Norbert Gotz, Michael Rack, Albrecht Harreus, Franz Rohl, Eberhard Ammermann, Volker Harries, Gisela Lorenz, Siegfried Strathmann
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Patent number: 5990161Abstract: Hydroximic acid derivatives, useful as pesticides, have the formula ##STR1## in which G is G.sub.3 or G.sub.4 having the formula: ##STR2## in which R.sub.5 is lower alkyl; R.sub.6 and R.sub.7 are, independently, hydrogen or lower alkyl; W is O, S, SO or SO.sub.2 ; X.sub.1, X.sub.2 and X.sub.3 are, independently, hydrogen or a variety of substituents; and R.sub.1, R.sub.2 and R.sub.3 are, independently, hydrogen or a variety of substituents.Type: GrantFiled: December 30, 1998Date of Patent: November 23, 1999Assignee: Rhone-Poulenc AgrochimieInventors: Yoshie Kirio, Takako Maeda, Norio Sasaki, Norishige Toshima, Nobumitsu Sawai, Bruce Milligan, Joseph Perez, Jean-Pierre Vors, Daniel B. Gant
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Patent number: 5401885Abstract: Ortho esters of the structure ##STR1## wherein R.sub.1 and R.sub.2 are different or the same alkyl moieties and can be a saturated, unsaturated, branched, unbranched or cyclic alkyl moiety of 1-3 carbon atoms, are prepared by first anhydrously reacting hydrogen cyanide or a hydrogen cyanide derivative with a secondary alkanol and hydrogen chloride in the presence of an inert organic solvent. Upon the formation of the resulting imino ether hydrochloride, more secondary alkanol is added to form the ortho esters (I). 1,1-Dialkoxycycloalkanes of the structure ##STR2## wherein R.sub.1 and R.sub.2 correspond to R.sub.1 and R.sub.2 of structure (I), and n is an integer from 4 to 9, are prepared by reacting with the imino ether hydrochloride more secondary alkanol and a cycloalkanone having 5 to 10 carbon atoms.Type: GrantFiled: June 1, 1993Date of Patent: March 28, 1995Assignee: Huls America, Inc.Inventors: Chitoor S. Subramaniam, Thomas V. John, David Colvin, George W. Bitler
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Patent number: 5393904Abstract: Copolymerizable oxime ethers of the general formula ##STR1## where A is a divalent linking member, R.sup.1 and R.sup.2 independently of one another are each C.sub.1 -C.sub.10 -alkyl, C.sub.1 -C.sub.10 -alkoxy, C.sub.5 -C.sub.10 -cycloalkyl or C.sub.5 -C.sub.10 -aryl, each of which may furthermore contain 1-3 nonadjacent nitrogen, oxygen or sulfur atoms as heteroatoms in the carbon chain or in the carbon ring and may be substituted by from one to three C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.4 -alkoxy groups, R.sup.1 or R.sup.2 may be hydrogen or R.sup.1 and R.sup.2 together form a bridge of 3 to 14 carbon atoms, where some of the carbon atoms may furthermore be part of an aromatic ring, Z is an n-valent organic radical which contains a copolymerizable ethylenically unsaturated group and n is an integer of from 1 to 3.Type: GrantFiled: February 25, 1994Date of Patent: February 28, 1995Assignee: BASF AktiengesellschaftInventors: Kaspar Bott, Gerhard Bauer, Karl Haeberle
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Patent number: 5393921Abstract: A process for synthesizing O-substituted oxime compounds, which includes (a) reacting an alkali metal or alkaline earth metal hydroxide compound and a solution of an oxime compound to form a first mixture including the alkali metal or alkaline earth metal salt of the oxime compound and water; and (b) adding an organohalide compound while stirring to the first mixture to form a second mixture including an O-substituted oxime compound, the alkali metal or alkaline earth metal salt of the oxime compound, water, unreacted organohalide compound and excess oxime compound. The second mixture is heated in the presence of an amount of water sufficient to react hydroxide with the unreacted organohalide compound to obtain an O-substituted oxime compound substantially free of unreacted organohalide compound.In a further embodiment, the O-substituted oxime compound can be hydrolyzed to the corresponding O-substituted hydroxylamine.Type: GrantFiled: July 7, 1993Date of Patent: February 28, 1995Assignee: The Gillette CompanyInventor: Harvey A. Lazar
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Patent number: 5319123Abstract: N-oxy substituted imidic acid derivative of the formula ##STR1## where R.sub.1, R.sub.2 and R.sub.3 are alkyl and aryl substituents, which are useful as antidiabetic and hypolipidemic agents are prepared by the following procedure: ##STR2## where X is chlorine, bromine, or iodine, and R.sub.1 ' is the same as R.sub.1 but with any hydroxy or carboxy groups present protected by a hydroxy or carboxy protecting group and, when R.sub.1 ' is a protected hydroxy or carboxy substituent, deprotecting the substituent.Type: GrantFiled: May 17, 1991Date of Patent: June 7, 1994Assignee: Sandoz Ltd.Inventors: George T. Lee, Ustun B. Sunay, Prasad K. Kapa
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Patent number: 5206403Abstract: A new diphenyl-methane derivative is useful to inhibit agglomeration of blood and is defined by the formula, including a diphenylethylene derivative and a benzophenone oxime either derivative. ##STR1## in which R1 and R2 each are hydrogen, hydroxyl or a lower alkoxy, U is .dbd.CXY or .dbd.N--O--W,X is hydrogen, cyano or --COR6, R6 being hydroxyl or an amino, Y is --R10--COR6, R3 being hydrogen or a lower alkoxy, R10 being an alkylene having 1 to 3 carbon atoms, straight or branched, --CO--NR4R5, R4 and R5 each being hydrogen, a lower alkyl or a lower arylalkyl, --CH2--NHSO2--C6H5 or --C(R8).dbd.NR7, R7 being a lower alkoxy or an aryl, R8 is --VR9, V being oxygen, sulfur or nitrogen, R9 being an alkyl or an aryl,W is --CH2--CO--CH2--COOR13, R13 being hydrogen or a lower alkyl, --CH2--C(.dbd.Type: GrantFiled: November 5, 1990Date of Patent: April 27, 1993Assignee: Eisai Co., Ltd.Inventors: Youji Yamagishi, Kozo Akasaka, Takeshi Suzuki, Mitsuaki Miyamoto, Kouji Nakamoto, Kazuo Okano, Shinya Abe, Hironori Ikuta, Kenji Hayashi, Hiroyuki Yoshimura, Tohru Fujimori, Koukichi Harada, Isao Yamatsu
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Patent number: 4975424Abstract: The present invention relates to a method for stabilizing a thiophosphoric acid ester of the formula (I), ##STR1## wherein R is a methyl or ethyl group, by adding at least one compound selected from the group consisting of polyols, polyalkylene glycols and their esters and ethers.According to the present invention, there is provided a highly active and stable soil pest controlling agent and agricultural composition.Type: GrantFiled: April 28, 1989Date of Patent: December 4, 1990Assignee: Sumitomo Chemical Company, LimitedInventor: Masao Ogawa
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Patent number: 4965390Abstract: O-substituted hydroxylamines of the formula IH.sub.2 NOR.sub.1 (I)in whichR.sub.1 is C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 haloakyl, --CH.sub.2 CR.sub.2 .dbd.CR.sub.3 R.sub.4 or --CH.sub.2 C.tbd.CR.sub.5 ;R.sub.2 is hydrogen, halogen or methyl;R.sub.3 is hydrogen, halogen or methyl;R.sub.4 is hydrogen, halogen or methyl; andR.sub.5 is hydrogen, methyl or ethyl,are prepared by reacting a nitrile of the formula IIR.sub.6 --CN (II)in which R.sub.6 is C.sub.1 -C.sub.4 alkyl, phenyl or benzyl, is reacted with an alcohol of the formula IIIR.sub.7 --OH (III)in which R.sub.7 is C.sub.1 -C.sub.5 alkyl, benzyl or C.sub.1 -C.sub.4 alkoxyethyl, in an organic solvent which is only sparingly miscible with water or not at all, in the presence of hydrogen halide HX, the suspension obtained of the iminoester hydrohalide of the formula IV ##STR1## in which R.sub.6 and R.sub.Type: GrantFiled: February 2, 1990Date of Patent: October 23, 1990Assignee: Ciba-Geigy CorporationInventor: Hans-Dieter Schneider
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Patent number: 4940699Abstract: The present invention relates to an O,O-diethyl O-1-(N-methoxyimino)ethyl thiophosphonate and O,O-diethyl O-1-(N-methoxyimino)-propyl thiophosphate useful to control pests living in soil. Said compounds have an excellent activity in controlling pests living in soil such as southern corn rootworm, cupreous chafer etc.Type: GrantFiled: April 28, 1989Date of Patent: July 10, 1990Assignee: Sumitomo Chemical Company, LimitedInventors: Yoshikazu Itoh, Makoto Hatakoshi, Mitsuru Sasaki
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Patent number: 4743701Abstract: Organo N-hydroxyimidates are prepared by reacting an organonitrile with an organic alcohol and with a hydrogen halide, in the presence of an organic solvent (which may include an excess of the organonitrile reactant), under anhydrous conditions, to form the corresponding organoimidate hydrohalide, and then reacting said organoimidate hydrohalide with a hydroxylamine salt and ammonia gas in the presence of an organic solvent (which can be the excess organonitrile from the first step), under anhydrous conditions, to produce the corresponding organo N-hydroxyimidate.Type: GrantFiled: December 10, 1986Date of Patent: May 10, 1988Assignee: Allied CorporationInventor: Chempolil T. Mathew
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Patent number: 4736055Abstract: Oxime sulfonates of formula I ##STR1## wherein Y is a polymerizable unsaturated group or epoxide group or an --OH, --NHR.sup.5, --COOH, COOR.sup.6, --COCl, --CH.sub.2 Hal, --SO.sub.2 Cl or --NCO group, Z is an (x+y)-valent connecting member, R.sup.1 and R.sup.2 are monovalent organic radicals, m is 0 or 1, x is 1 or 2 and y is 1 or 2, can be converted into polymers which can be thermally or photochemically dissociated to form free sulfonic acid groups. Said polymers can therefore be used as photoresists which can be developed with aqueous alkalis.Type: GrantFiled: April 11, 1986Date of Patent: April 5, 1988Assignee: Ciba-Geigy CorporationInventors: Kurt Dietliker, Werner Rutsch, Godwin Berner, Max Hunziker, Christopher G. Demmer
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Patent number: 4690708Abstract: A herbicide of the formula: ##STR1## in which: Z is N or CX',W, Y, Y', X, Z' and X' represent H, a halogen atom, NO.sub.2, CN or a polyhalogenoalkyl, alkyl or alkoxy group,R.sup.2 represents H, halogen, substituted alkyl, allyl, propargyl, CN, NR.sup.4 R.sup.5, C(X.sup.2)R.sup.7, C(X.sup.2)X.sup.3 R.sup.8, C(X.sup.2)NR.sup.4 R.sup.5, SO.sub.2 F, SO.sub.2 OR.sup.8, SO.sub.2 NR.sup.4 R.sup.5 or P(X.sup.2)R.sup.9 R.sup.10,R.sup.1 is halogen, X.sup.2 R.sup.3 or NR.sup.4 R.sup.5,R.sup.3 is optionally substituted alkyl or is allyl or propargyl,R.sup.4, R.sup.7 and R.sup.8 represent H, alkyl, cycloalkyl, phenyl, allyl, propargyl or the like,R.sup.5 represents R.sup.4, a cation or OR.sup.6, R.sup.6 being H, a cation or alkyl,X.sup.2 and X.sup.3 are O or S,R.sup.9 and R.sup.10 are H, alkyl, OH, OM or R.sup.1, andM is a cation.Type: GrantFiled: July 11, 1984Date of Patent: September 1, 1987Assignee: Rhone-Poulenc AgrochimieInventors: Alain Chene, Guy Borrod
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Patent number: 4659366Abstract: Herbicidally and fungicidally active novel 2-(alkoximiminoalkoxycarbonyl)-phenylsulphonylureas of the formula ##STR1## in which R.sup.1 represents hydrogen, halogen, alkyl, halogenoalkyl, alkoxy or nitro,R.sup.2 represents hydrogen, alkyl or optionally substituted aryl,R.sup.3 represents hydrogen or alkyl,R.sup.4 represents hydrogen, alkyl, alkoxy, alkylthio, alkoxyalkyl, alkylthioalkyl, cyano, alkoxycarbonyl or optionally substituted aryl,R.sup.5 represents hydrogen, alkyl, alkenyl, alkinyl, halogenoalkyl, halogenoalkenyl, alkoxyalkyl, alkylthioalkyl or optionally substituted aralkyl,Y represents oxygen or sulphur andHet represents a heterocyclic radical of the formula ##STR2## wherein E represents nitrogen or the CH group andR.sup.6 and R.sup.7 independently of one another each represent alkyl, alkoxy or alkoxyalkyl.Type: GrantFiled: March 27, 1985Date of Patent: April 21, 1987Assignee: Bayer AktiengesellschaftInventors: Jorg Stetter, Robert R. Schmidt, Hans-Joachim Santel, Gerd Hanssler, Ludwig Eue
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Patent number: 4629802Abstract: A novel process for producing sulfonylureas of the formula I having a herbicidal action and an action regulating plant growth ##STR1## wherein A is an unsubstituted or substituted phenyl, naphthyl, furan, thiophene or pyridine group, E is a nitrogen atom or the methine group, R.sub.a is hydrogen, halogen, C.sub.1 -C.sub.5 -alkyl, C.sub.1 -C.sub.5 -haloalkyl, C.sub.1 -C.sub.5 -alkoxy, C.sub.1 -C.sub.5 -haloalkoxy, C.sub.1 -C.sub.5 -alkylthio or C.sub.2 -C.sub.10 -alkoxyalkoxy, and R.sub.b is the same as R.sub.Type: GrantFiled: March 1, 1985Date of Patent: December 16, 1986Assignee: Ciba-Geigy CorporationInventors: Haukur Kristinsson, Werner Topfl
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Patent number: 4614813Abstract: This invention relates to a process for preparing N-hydroxyl organo imidate compounds by reacting an oxime compound with a halogenating agent and reacting the resulting 1-halosubstituted oxime compound with the alkali metal or alkaline earth metal salt of an alcohol.Type: GrantFiled: April 12, 1984Date of Patent: September 30, 1986Assignee: Allied CorporationInventors: Chempolil T. Mathew, Harry E. Ulmer