Boron Containing Patents (Class 558/72)
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Patent number: 9324960Abstract: Novel semiconducting polymers have been formed via the electron-induced cross-linking of orthocarborane B10C2H2 and 1,4-diaminobenzene. The films were formed by co-condensation of the molecular precursors and 200 eV electron-induced cross-linking under ultra-high vacuum (UHV) conditions. Ultraviolet photoemission spectra show that the compound films display a shift of the valence band maximum from ˜4.3 eV below the Fermi level for pure boron carbide to ?1.7 eV below the Fermi level when diaminobenzene is added. The surface photovoltage effect decreases with decreasing B/N atomic ratio. A neutron detector comprises the polymer as the p-type semiconductor to be paired with an n-type semiconductor.Type: GrantFiled: June 4, 2012Date of Patent: April 26, 2016Assignee: QUANTUM DEVICES, LLCInventors: Peter Dowben, Jeffry Kelber
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Publication number: 20140093935Abstract: Mitigation of photo-induced damage in excitation illuminated reactions and analyses utilizing such reactions results in an enhanced performance for the reactions and the analyses. There is provided a novel class of triplet-state quenchers for mitigating photo-induced damage which are both simple in structure and effective at preventing and/or reducing photo-induced damage to reaction components of excitation illuminated reaction mixtures. Also provided are methods of using the compounds of the invention, devices and kits incorporating the compounds of the invention.Type: ApplicationFiled: September 27, 2013Publication date: April 3, 2014Applicant: Pacific Biosciences of California, Inc.Inventors: Gene Shen, Andrei Fedorov, Wei-Chuan Sun, Stephen Yue
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Patent number: 8546607Abstract: Embodiments of the invention provide methods and materials for chemical cross-coupling reactions that utilize unconventional phenol derivatives as cross-coupling partners. Embodiments of the invention can be used to synthesize a variety of useful organic compounds, for example the anti-inflammatory drug flurbiprofen.Type: GrantFiled: September 24, 2010Date of Patent: October 1, 2013Assignee: The Regents of the University of CaliforniaInventors: Neil K. Garg, Kyle W. Quasdorf, Xia Tian
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Patent number: 8513451Abstract: Compositions, methods of synthesis and applications of phospholipase A2 (PLA2) specific enzyme substrates which exhibit fluorescence resonance energy transfer (FRET) are described. The compounds generally have the structure: (I) wherein, the variables are described throughout the application. These novel compounds provide a sensitive method to monitor real time PLA2 specific enzyme activities in various cells, tissues and small organisms with fluorescence-ratiometric analysis.Type: GrantFiled: May 30, 2008Date of Patent: August 20, 2013Inventor: Hee Chol Kang
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Publication number: 20120028132Abstract: [Summary] An object of the present invention is to find a new electrolyte having a characteristics for the electrolyte for an electrochemical device and to provide excellent electrolytic solution for a nonaqueous electrolyte battery and nonaqueous electrolyte battery which use this. [Solving Means] To provide an electrolyte for an electrochemical device, having a chemical structure formula represented by a general formula (1). where M is a group 13 or 15 group element of the periodic table; A+ is an alkali metal ion or an onium ion; m is a number of 1-4 when M is a group 13 element, and is a number of 1-6 when M is a group 15 element; n is a number of 0-3 when M is a group 13 element, and is a number of 0-5 when M is a group 15 element; and R is a halogen atom, a C1-C10 halogenated alkyl group, a C6-C20 aryl group, a C6-C20 halogenated aryl group.Type: ApplicationFiled: March 23, 2010Publication date: February 2, 2012Applicant: Central Glass Company, LimitedInventors: Shoichi Tsujioka, Toshinori Mitsui, Yuki Kondo, Aiichiro Fujiwara
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Publication number: 20120010424Abstract: Disclosed are compounds according to formula (I) as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors; such methods including treating cancer, producing radioprotection and/or radiomitigation, enhancing cell proliferation, treating a wound, treating apoptosis or preserving or restoring function in a cell, tissue, or organ, culturing cells, preserving organ or tissue function, and treating a dermato logical condition.Type: ApplicationFiled: March 3, 2009Publication date: January 12, 2012Inventor: Veeresh Gududuru
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Publication number: 20110213061Abstract: The invention relates to a method for producing mono-aminofunctionalized dialkylphosphinic acids and esters and salts thereof, characterized in that a) a phosphinic acid source (I) is reacted with olefins (IV) to yield an alkylphosphonic acid, salt or ester (II) thereof in the presence of a catalyst A, b) the thus obtained alkylphosphonic acid, salt or ester (II) thereof is reacted with acetylenic compounds of formula (V) to yield a mono-functionalized dialkylphosphinic acid derivative (VI) in the presence of a catalyst B, and c) the thus obtained mono-functionalized dialkylphosphinic acid derivative (VI) is reacted with a hydrogen cyanide source to yield a mono-functionalized dialkylphosphinic acid derivative (VII) in the presence of a catalyst C, and d) the thus obtained mono-functionalized dialkylphosphinic acid derivative (VII); is reacted to yield a mono-aminofunctionalized dialkylphosphinic acid derivative (III) in the presence of a catalyst D or a reduction agent, wherein R1, R2, R3, R4, R5, R6 are theType: ApplicationFiled: October 6, 2009Publication date: September 1, 2011Applicant: CLARIANT FINANCE (BVI) LIMITEDInventors: Michael Hill, Werner Krause, Martin Sicken
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Patent number: 7820065Abstract: This invention relates to an additive for a non-aqueous electrolyte of an electric double layer capacitor comprising a combustion inhibiting substance releasing compound capable of releasing a combustion inhibiting substance having particularly excellent combustion inhibiting effect during combustion, and more particularly to an additive for a non-aqueous electrolyte of an electric double layer capacitor comprising a combustion inhibiting substance releasing compound which releases a combustion inhibiting substance during combustion, characterized in that the combustion inhibiting substance is a phosphine oxide compound having P—F bond and/or P—NH2 bond in its molecule.Type: GrantFiled: March 29, 2005Date of Patent: October 26, 2010Assignee: Bridgestone CorporationInventor: Masashi Ohtsuki
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Publication number: 20100203564Abstract: Compositions, methods of synthesis and applications of phospholipase A2 (PLA2) specific enzyme substrates which exhibit fluorescence resonance energy transfer (FRET) are described. The compounds generally have the structure: (I) wherein, the variables are described throughout the application. These novel compounds provide a sensitive method to monitor real time PLA2 specific enzyme activities in various cells, tissues and small organisms with fluorescence-ratiometric analysis.Type: ApplicationFiled: May 30, 2008Publication date: August 12, 2010Applicant: LIFE TECHNOLOGIES CORPORATIONInventor: Hee Chol Kang
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Patent number: 7396947Abstract: The present invention relates to biarylbisphosphines and intermediates thereof. The scope of the invention further encompasses catalysts preparable from the biarylbisphosphines and their use in asymmetric syntheses.Type: GrantFiled: June 2, 2004Date of Patent: July 8, 2008Assignee: LANXESS Deutschland GmbHInventors: Benjamin Meseguer, Dieter Arlt
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Patent number: 7122699Abstract: The invention relates to a process for the preparation of organic boronic acid derivatives involving the reaction of an organic compound with diboronic acid in the presence of a Group 8-11 metal catalyst.Type: GrantFiled: June 13, 2003Date of Patent: October 17, 2006Assignee: Boron Molecular LimitedInventors: Sebastian Mario Marcuccio, Mary Rodopoulos, Helmut Weigold
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Patent number: 6828352Abstract: The present invention relates to synthetic, novel, preferably fatty phosphoric acid esters which, when neutralized with a neutralizing agent, is revealed as a new surface active agent. Formulations are presented which demonstrate a method for using the disclosed surface active agent to prepare stable oil-in-water, water-in-oil emulsions and various solutions of varying polarity and viscosity for use in a variety of dermatological applications, and/or wherever emulsions or solutions according to the present invention may be used.Type: GrantFiled: January 28, 2003Date of Patent: December 7, 2004Assignee: Walter Merton Company, Inc.Inventor: Arnold W. Fogel
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Patent number: 6599507Abstract: A complex of alpha-fetoprotein (AFP) and N-arachidonoyl aminoethyl phosphate (N-AAP) is shown to have significant immunostimulating properties and can therefore be used as a therapeutic agent in various indications, such as immune deficiencies and in particular immune deficiencies related to cancer therapy.Type: GrantFiled: December 15, 2000Date of Patent: July 29, 2003Assignee: Ardenia Investments, Ltd.Inventor: Oleg Strelchenok
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Patent number: 6248916Abstract: A general synthetic method has been developed for the rapid and efficient production of a variety of boron-rich macromolecules suitable for conjugation with inclusion in receptor-mediated delivery systems as well as other delivery systems. Preparation techniques have been developed to yield precisely ordered oligophosphates which are soluble, hydrophilic, may be homogeneous, and may be prepared with a variety of functional groups.Type: GrantFiled: January 5, 1999Date of Patent: June 19, 2001Assignee: Regents of the University of CaliforniaInventors: Robert R. Kane, M. Frederick Hawthorne
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Patent number: 6031117Abstract: The present invention provides arylboronic acid reagents useful for incorporation into modified oligonucleotides and polynucleotides. The modified oligonucleotides and polynucleotides thus produced are useful in bioconjugation reactions for the immobilization and purification of macromolecules.Type: GrantFiled: March 19, 1999Date of Patent: February 29, 2000Assignee: Prolinx IncorporatedInventors: Robert J. Kaiser, Mark L. Stolowitz
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Patent number: 5856551Abstract: A general synthetic method has been developed for the rapid and efficient production of a variety of boron-rich macromolecules suitable for conjugation with of inclusion in receptor-mediated delivery systems as well as other delivery systems. Preparation techniques have been developed to yield precisely ordered oligophosphates which are soluble, hydrophilic, may be homogeneous, and may be prepared with a variety of functional groups.Type: GrantFiled: February 27, 1997Date of Patent: January 5, 1999Assignee: The Regents of the University of CaliforniaInventors: Robert R. Kane, M. Frederick Hawthorne
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Patent number: 5539141Abstract: Described are mixed boric acid/phosphoric acid esters which may be obtained by subjecting at least one phosphorus compound capable of ester formation and at least one boron compound capable of ester formation simultaneously to an esterification reaction with at least one polyol and/or a derivative thereof capable of ester formation. Such esters may be prepared in an aqueous medium and find use in the flame-proofing treatment of a variety of materials, as acid catalysts for acid-curing synthetic materials, for controlling boron deficiencies in cultivated plants, and in many other fields of application.Type: GrantFiled: February 21, 1995Date of Patent: July 23, 1996Assignee: Chemische Fabrik Budenheim Rudolf A. OetkerInventors: Karlheinz Dorn, Klaus Frankenfeld, Hans-Dieter Nagerl, Sonja Schlarb, Klaus Sommer
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Patent number: 5487838Abstract: This invention relates to a composition prepared by reacting (A) a boron compound and (B) a phospholipid. These phospholipids are useful as lubricant additives for oil-base and water-base functional fluids. These materials act as anti-wear and/or extreme pressure agents. Further, these materials when incorporated into aqueous compositions have beneficial bacteriostatic effects, i.e., controlling bacterial growth.Type: GrantFiled: March 28, 1994Date of Patent: January 30, 1996Assignee: The Lubrizol CorporationInventors: Carmen V. Luciani, Syed Q. A. Rizvi
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Patent number: 5473091Abstract: A novel quaternary phosphorus compound is a salt between tetraphenyl borate and a phosphonium having an aromatic group attached to a phosphorus atom through an oxygen atom. It is blended with an epoxy resin as a curing catalyst to form an epoxy resin composition which flows smoothly and quickly cures into a product having improved moisture resistance and adhesion.Type: GrantFiled: March 7, 1995Date of Patent: December 5, 1995Assignee: Shin-Etsu Chemical Co., Ltd.Inventors: Nobuhiro Ichiroku, Koji Futatsumori, Kazuhiro Arai, Miyuki Wakao, Toshio Shiobara
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Patent number: 5462724Abstract: Compounds of formula I and II ##STR1## in which B contains a carboranyl group and one of R.sub.3 and R.sub.4 is a carboranyl group or a boronic acid or ester are useful sensitizing agents for boron neutron capture therapy.Type: GrantFiled: January 30, 1995Date of Patent: October 31, 1995Inventors: Raymond F. Schinazi, Dennis C. Liotta
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Patent number: 5434143Abstract: The phosphite-borane compounds of the present invention correspond to the formula ##STR1## where R.sub.1 is independently selected from H, C.sub.1 -C.sub.20 alkyl, alkylaryl, aryl, trialkylsilyl, with the proviso that both R.sub.1 groups cannot simultaneously be H.sub.1, andR.sub.2 is selected from H, a monovalent cation such as Li.sup.+, Na.sup.+, K.sup.+, NH.sub.4.sup.+, N(R.sub.3.sup.+).sub.4, where R.sub.3 is independently selected from H, C.sub.1 -C.sub.20 alkyl.The phosphite-borane compounds of the present invention are bioactive in character, variously exhibiting anti-tumor, anti-inflammatory, and hypolipidemic activity. Also disclosed are various synthetic methods for making such phosphite-borane compounds, and for formulating same in unit dosage forms as well as other pharmaceutically and pharmacologically acceptable formulations.Type: GrantFiled: October 19, 1994Date of Patent: July 18, 1995Assignee: Boron Biologicals, Inc.Inventors: Bernard F. Spielvogel, Anup Sood
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Patent number: 5399732Abstract: Methods of making phosphite-borane compounds of the formula ##STR1## wherein: each R.sub.1 is independently selected from: H; C.sub.1 -C.sub.10 alkyl; alkylaryl; aralkyl; aryl; monovalent metal ions; nucleosides; and quaternary ammonium ions, (R.sub.4).sub.4 N.sup.+, in which the substituents R.sub.4 of the ammonium nitrogen atom are H or C.sub.1 -C.sub.10 alkyl;R.sub.2 is H or C.sub.1 -C.sub.10 alkyl; andR.sub.3 is CNCH.sub.2 CH.sub.3.sup.+ BF.sub.4.sup.-, COOH, carboxyl salts, COOR.sub.5, or CONHR.sub.5, wherein R.sub.5 is C.sub.1 -C.sub.10 alkyl, alkylaryl, aralkyl, or aryl;with the proviso that if at least one of the R.sub.1 substituents is H, nucleoside, monovalent metal ion, or quaternary ammonium ion, then R.sub.3 may also be CN,via synthetic routes comprising hydrolysis. The phosphorous-boron adducts of the invention are bioactive in character, variously exhibiting anti-tumor, anti-inflammatory, and hypolipidemic activity.Type: GrantFiled: October 14, 1993Date of Patent: March 21, 1995Assignee: Boron Biologicals Inc.Inventors: Bernard F. Spielvogel, Anup Sood
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Patent number: 5272250Abstract: A class of pharmaceutically active boronated compounds are provided. The boronated compounds include boronated phosphoramidates, and boronated nucleosides, and oligomers thereof. The compounds are boronated by an aminoalkyl substituted polyborane, carborane, metallopolyborane or metallocarborane.Type: GrantFiled: July 10, 1992Date of Patent: December 21, 1993Inventors: Bernard F. Spielvogel, Anup Sood
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Patent number: 5260427Abstract: Nucleosidyl phosphite-borane compounds of the formula: ##STR1## wherein: Nucleoside is a natural or synthetic nucleoside connected to the phosphorus atom via a hydroxyl oxygen; each X is independently selected from O and BHR.sub.3 R.sub.4 ;R.sub.1 is selected from H, alkyl, aryl, alkyaryl, monovalent metal ions, and ammonium cation; R.sub.2 is selected from OR.sub.1 and N(R.sub.5).sub.2, wherein R.sub.5 is independently selected from H, C.sub.1 -C.sub.10 linear or branched alkyl or aryl; R.sub.3 is selected from H, CN, COOH, carboxyl salts, COOR.sub.6 and CONHR.sub.6, wherein R.sub.6 is selected from H, C.sub.1 -C.sub.10 alkyl, alkylaryl and aryl; R.sub.4 is selected from H and C.sub.1 -C.sub.10 alky; and n is 1 to 2.Type: GrantFiled: July 6, 1992Date of Patent: November 9, 1993Assignee: Boron Biolgicals, Inc.Inventors: Bernard F. Spielvogel, Anup Sood
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Patent number: 5256324Abstract: Preconditioned automatic transmission fluids are made by using a preblend formed by heating an alkenyl succinimide or succinamide dispersant with a phosphorus ester and water to partially hydrolyze the ester and then mixing the preblend and other additives with a base oil.Type: GrantFiled: September 27, 1991Date of Patent: October 26, 1993Assignee: Ethyl Petroleum Additives, Inc.Inventor: Andrew G. Papay
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Patent number: 5254706Abstract: Phosphite-borane compounds of the formula ##STR1## wherein: each R.sub.1 is independently selected from: H; C.sub.1 -C.sub.10 alkyl; alkylaryl; aralkyl; aryl; monovalent metal ions; nucleosides; and quaternary ammonium ions, (R.sub.4).sub.4 N.sup.+, in which the substituents R.sub.4 of the ammonium nitrogen atom are H or C.sub.1 -C.sub.10 alkyl;R.sub.2 is H or C.sub.1 -C.sub.10 alkyl; andR.sub.3 is CNCH.sub.2 CH.sub.3 .sup.+ BF.sub.4.sup.-, COOH, carboxyl salts, COOR.sub.5, or CONHR.sub.5, wherein R.sub.5 is C.sub.1 -C.sub.10 alkyl, alkylaryl, aralkyl, or aryl;with the proviso that if at least one of the R.sub.1 substituents is H, nucleoside, monovalent metal ion, or quaternary ammonium ion, then R.sub.3 may also be CN.The phosphorous-boron adducts of the invention are bioactive in character, variously exhibiting anti-tumor, anti-inflammatory, and hypolipidemic activity.Type: GrantFiled: August 31, 1992Date of Patent: October 19, 1993Assignee: Boron Biologicals, Inc.Inventors: Bernard F. Spielvogel, Anup Sood
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Patent number: 5194166Abstract: Lubricant additives are produced by reacting an alkoxylated amine with phosphorous acid. The additives preferably also contain a boron moiety which is reacted with the phosphorous acid and amine, preferably in a one step reaction. More preferably, a mono-functional alcohol or a long-chain aliphatic carboxylic acid is added to this mixture. The additives are particularly useful in metal working oils and particularly as extreme pressure additives to replace the currently used chlorinated paraffin additives.Type: GrantFiled: July 10, 1992Date of Patent: March 16, 1993Assignee: The Elco CorporationInventors: Gerald D. Burt, Randolph A. McDonald
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Patent number: 5144045Abstract: Phospocholine derivatives having the formula: ##STR1## in which W, Z, Q and R are described in the specification are disclosed as useful for inhibiting the enzyme phospholipase A.sub.2. Methods of making and using the compounds are also disclosed.Type: GrantFiled: November 13, 1990Date of Patent: September 1, 1992Assignee: American Cyanamid CompanyInventors: Allan Wissner, Robert E. Schaub, Kenneth E. Green, Philip R. Hamann
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Patent number: 5143907Abstract: Phosphite-borane compounds of the formula ##STR1## wherein: each R.sub.1 is independently selected from: H; C.sub.1 -C.sub.10 alkyl; alkylaryl; aralkyl; aryl; monovalent metal ions; nucleosides; and quaternary ammonium ions, (R.sub.4).sub.4 N.sup.+, in which the substituents R.sub.4 of the ammonium nitrogen atom are H or C.sub.1 -C.sub.10 alkyl;R.sub.2 is H or C.sub.1 -C.sub.10 alkyl; andR.sub.3 is CNCH.sub.2 CH.sub.3.sup.+ BF.sub.4.sup.-, COOH, carboxyl salts, COOR.sub.5, or CONHR.sub.5, wherein R.sub.5 is C.sub.1 -C.sub.10 alkyl, alkylaryl, aralkyl, or aryl;with the proviso that if at least one of the R.sub.1 substituents is H, nucleoside, monovalent metal ion, or quaternary ammonium ion, then R.sub.3 may also be CN. The phosphorous-boron adducts of the invention are bioactive in character, variously exhibiting anti-tumor, anti-inflammatory, and hypolipidemic activity.Type: GrantFiled: May 10, 1991Date of Patent: September 1, 1992Assignee: Boron Biologicals, Inc.Inventors: Bernard F. Spielvogel, Anup Sood, Iris H. Hall
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Patent number: 5043465Abstract: New organic phosphorus compounds, comprised of hetero-phosphacycloalkanes whose phosphorus atom forms a complex with a borane. They can be prepared by the action of a borane on a hetero-phosphacycloalkane, within a solvent, at temperatures ranging from -20.degree. to +60.degree. C. Their transformation into other derivatives, phosphinites or phosphines in particular, can be carried out without any modification in the chirality of the initial complex. An especially useful application is their conversion into highly optically active phosphines, used in particular as catalysts in various reactions.Type: GrantFiled: December 28, 1989Date of Patent: August 27, 1991Assignee: Societe Nationale Elf AquitaineInventors: Sylvain Juge, Jean-Pierre Genet
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Patent number: 4755311Abstract: This invention is directed to borated amine salts of dihydrocarbyl monothiophosphoric acids, and to lubricating and functional fluid compositions containing said borated amine salts. The lubricating and functional fluid compositions have improved extreme pressure properties and high temperature stability.The borated amine salts of the invention may be characterized by the formula ##STR1## or mixtures thereof wherein R.sup.1 and R.sup.2 are each independently hydrocarbyl groups containing from 1 to about 30 carbon atoms. In one preferred embodiment, the amine salts are derived from hydroxyhydrocarbyl amines.The lubricating and functional fluid compositions may contain, in addition to the borated amine salts, at least one nitrogen-containing composition prepared by the reaction of a hydrocarbon-substituted succinic acid-producing compound with at least about one-half equivalent, per equivalent of acid-producing compound, of an amine containing at least one hydrogen attached to a nitrogen atom.Type: GrantFiled: August 14, 1986Date of Patent: July 5, 1988Assignee: The Lubrizol CorporationInventors: Louis Burjes, Stephen A. DiBiase
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Patent number: 4734517Abstract: Certain novel esters of N-phosphonomethylaminomethylboronic acid are found to exhibit herbicidal properties.Type: GrantFiled: October 24, 1986Date of Patent: March 29, 1988Assignee: Monsanto CompanyInventor: Dennis P. Phillion