And Reactant Having Chalcogen-containing Hetero Ring Patents (Class 558/91)
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Patent number: 9115154Abstract: The present disclosure discloses a method of preparing tris-(2-chloroethyl)phosphite, comprising: continuously pumping phosphorus trichloride and ethylene oxide into a tubular pre-mixer for pre-mixing, respectively, and starting a refrigerant cooling unit of the microchannel reaction device simultaneously, to obtain a product tris-(2-chloroethyl)phosphite after complete reaction. The method according to the present disclosure not only significantly improves the content of the esterification product, thus increasing the production efficiency by 10 to 100 times than that of an ordinary tank reactor, but also reduces the residence time of the esterification product in the reactor from 110 hours to several minutes.Type: GrantFiled: May 7, 2015Date of Patent: August 25, 2015Assignee: SHAOXING EASTLAKE BIOCHEMICAL CO., LTD.Inventors: Guoyan Ji, Chengrong Ding, Guofu Zhang, Sheng Ji, Guoyao Ji, Xiaoying Ji, Huadong Yang
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Publication number: 20120172506Abstract: A polyphosphonate having an acid value of about 5.5 mg KOH/g or less and represented by Formula 1: wherein: A is a single bond, C1 to C5 alkylene, C1 to C5 alkylidene, C5 to C6 cycloalkylidene, —S— or —SO2-, R is substituted or unsubstituted C6 to C20 aryl or substituted or unsubstituted C6 to C20 aryloxy, R1 and R2 are the same or different and are each independently substituted or unsubstituted C1 to C6 alkyl, substituted or unsubstituted C3 to C6 cycloalkyl, substituted or unsubstituted C6 to C 12 aryl or halogen, a and b are the same or different and are each independently an integer from about 0 to about 4, and n is an integer from about 1 to about 500.Type: ApplicationFiled: December 20, 2011Publication date: July 5, 2012Applicant: CHEIL INDUSTRIES INC.Inventors: Min Soo LEE, Chang Hong KO, Seon Ae LEE, Sang Hyun HONG
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Patent number: 7273945Abstract: The invention describes a process for preparing alkoxylated, phosphorus-containing compounds, using heterogeneous catalysts based on metal oxides of aluminum, so that the product can be worked up anhydrously.Type: GrantFiled: March 15, 2006Date of Patent: September 25, 2007Assignee: LANXESS Deutschland GmbHInventors: Thomas Weiss, Wolfgang Grape, Rainer Elbert, Jan- Gerd Hansel, Johannes Kaulen
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Patent number: 6972339Abstract: Dye reagents useful in labeling biological materials are provided along with methods for their use.Type: GrantFiled: December 21, 2001Date of Patent: December 6, 2005Assignee: Epoch Biosciences, Inc.Inventors: Eugeny A. Lukhtanov, Alexei V. Vorobiev, Michael W. Reed, Nicolaas M. J. Vermeulen
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Publication number: 20040210076Abstract: The present invention relates to process wherein (+)-2-carene epoxide is coupled with a compound X-Y that contains nucleophilic and electrophilic moieties, to produce a compound of formula (5). The reaction mixture consists essentially of a source of (+)-2-carene epoxide, compound X-Y, optionally an inert solvent and optionally a pH buffer. No acid catalyst is used in the process.Type: ApplicationFiled: June 7, 2004Publication date: October 21, 2004Inventors: Michael Casner, Theodore Maurice Resnick, Lee Jonathan Silverberg
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Patent number: 6737536Abstract: This invention relates to inositolphospholipids, particularly to synthetic phosphatidyl-myo-inositols (PtdIns), ceramide-phosphoinositols (CerPhosIns) and their structural and stereochemical analogues. The invention specifically provides a novel approach to synthesis of inositolphospholipids which is suitable for laboratory scale preparation as well as for large scale industrial production. The synthetic approach is applicable equally well for the preparation of inositolphospholipids carrying saturated lipid chains, unsaturated lipid chains with one or more double or triple bonds, chains with hydroxyl, amino and other functional groups, or combinations of these. In addition, it provides novel high purity diastereomer molecular species of inositolphospholipids that have unequivocally defined structure and absolute stereochemistry in both the myo-inositol and the glycerol residues and are obtainable only by the present new approach.Type: GrantFiled: February 4, 2002Date of Patent: May 18, 2004Assignee: Nutrimed BiotechInventor: Rajindra Aneja
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Patent number: 6096916Abstract: Disclosed are unique starting materials, reaction sequences and intermediate compounds for the preparation of D-3-phosphorylated phosphoinositides (3-PPI) of unambiguous structure and absolute stereochemistry. The enantiomerically pure D-3-phosphorylated phosphoinositides also provided have many uses, including in the development of diagnostics and therapeutics based on the roles of 3-PPI in intracellular signaling.Type: GrantFiled: July 27, 1999Date of Patent: August 1, 2000Assignee: Nutrimed BiotechInventor: Rajindra Aneja
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Patent number: 5652207Abstract: Novel bleaches, a method for bleaching substrates using these materials and detergent compositions containing same are reported. The bleaches are phosphinoyl imines. Substrates such as fabrics may be bleached in an aqueous solution containing the phosphinoyl imines and a peroxygen compound.Type: GrantFiled: August 12, 1996Date of Patent: July 29, 1997Assignee: Lever Brothers Company, Division of Conopco, Inc.Inventor: Naresh Dhirajlal Ghatlia
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Patent number: 5627299Abstract: A process of preparing tribromoneopentyl chloroalkyl phosphates comprising a first step of reacting phosphorus oxychloride with tribromoneopentyl alcohol and a second step of reacting the resultant formed in the first step with an alkylene oxide after a step of removing hydrochloric acid and unreacted phosphorus oxychloride present in the first reaction mixture to obtain a compound represented by the formula (1): ##STR1## , wherein R represents a hydrogen atom, or an alkyl or chloroalkyl group and n is from 0.95 to 1.15.Type: GrantFiled: March 15, 1996Date of Patent: May 6, 1997Assignee: Daihachi Chemical Industry Co., Ltd.Inventors: Noriaki Tokuyasu, Nobutaka Miyano
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Patent number: 5159082Abstract: A process for producing an aromatic compound is disclosed, which comprises coupling an aromatic sulfinic acid or a salt thereof with an aromatic halogen compound having at least one halogen atom attached to the carbon atom of the aromatic nucleus thereof or a vinyl group-containing halogen compound having at least one halogen atom attached to the carbon atom of said vinyl group in the presence of a catalyst compound containing an element selected from platinum metals.Type: GrantFiled: June 25, 1990Date of Patent: October 27, 1992Assignee: Mitsubishi Kasei CorporationInventors: Keiichi Sato, Toru Okoshi
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Patent number: 5151539Abstract: Glycol bisphosphate compounds are formed by first hydrolytically condensing a dihydrocarbylhalophosphate to form a tetrahydrocarbyl pyrophosphate and then reacting the pyrophosphate with a cyclic ether to form the glycol bisphosphate.Type: GrantFiled: May 28, 1991Date of Patent: September 29, 1992Assignee: Akzo America Inc.Inventors: Danielle A. Bright, Alan M. Aaronson
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Patent number: 5082867Abstract: Flame retardant additive compositions for flexible polyurethane foam comprise pentabromodiphenyl ether and non-mutagenic halogenated alkyl phosphate ester mixtures of the formula: ##STR1##Type: GrantFiled: September 28, 1989Date of Patent: January 21, 1992Assignee: Great Lakes Chemical CorporationInventors: David E. May, Richard S. Rose
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Patent number: 5041596Abstract: Glycol bisphosphate compounds are formed by first hydrolytically condensing a dihydrocarbylhalophosphate to form a tetrahyrocarbyl pyrophosphate and then reacting the pyrophosphate with a cyclic ether to form the glycol bisphosphate.Type: GrantFiled: July 3, 1989Date of Patent: August 20, 1991Assignee: Akzo America Inc.Inventors: Danielle A. Bright, Alan M. Aaronson
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Patent number: 4885381Abstract: Included are halogenated phosphate-phosphites and their acid halides and acids. The halogenated phosphate-phosphites can be prepared by a process comprising serially contacing(A) a phosphorus trihalide with a triol;(B) a halogenating agent; and(C) an oxirane or an alcohol;under conditions sufficient to prepare the halogenated phosphate-phosphite. Steps (A) and (B) can prepare their acid halides. Use of water in step (C) can prepare their acids. For example, 3-((bis(2-chloroethoxy)phosphino)oxy)(2-bromoethyl-2-methylpropyl, 2-bromoethyl, 2-chloroethyl)phosphorate can be prepared from 2-methyl-2-(hydroxymethyl)-1,3-propanediol; phosphorus trichloride; bromine; and ethylene oxide.Also included is use of the compounds as a hyraulic fluid or flame retardant. For example, polyurethanes can be rendered less flammable with the halogenated phosphate-phosphite flame retardant.Type: GrantFiled: April 11, 1988Date of Patent: December 5, 1989Assignee: The Dow Chemical CompanyInventor: Chester E. Pawloski
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Patent number: 4864049Abstract: Novel (halo)(hydroxy)-substituted phosphorus-containing acid derivatives are disclosed. Preferred compounds are 2-halo-3-hydroxypropyl ester derivatives of phosphorus and phosphoric acid formed by reaction of at least some amount of tertiary butyl glycidyl ether with a halogenated derivative of a phosphorus-containing acid followed by acid dealkylation of the product. The polyol products are useful in the production of polyurethane articles such as foams having increased resistance to the effects of fire. The derivatives can be additives or reactants in the polyurethane, depending on the presence or absence of terminal hydroxyl groups within the given ester moieties.Type: GrantFiled: March 21, 1988Date of Patent: September 5, 1989Assignee: The Dow Chemical CompanyInventors: Chester E. Pawloski, Sally P. Ginter
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Patent number: 4851559Abstract: Included are the title phosphorate compounds, and a process to prepare them comprising contacting a carbylphosphorate mono acid halide with a carbyloxide. For example, ((2-(3-bromo-2,2-bis(bromomethyl)propxy)ethyl(chloroethyl)-(ethyl))phospho rat e can be prepared with (2-(3-bromo-2,2-bis(bromomethyl)propoxy)ethyl)(ethyl)chloridophosphorate and ethylene oxide. The compounds are useful so-called flame-retardants for polyurethanes, especially flexible foams because, for example, substantially non-scorching and non-odoriferous flame-retardant flexible foams can be readily prepared with the compounds.Type: GrantFiled: August 11, 1986Date of Patent: July 25, 1989Assignee: The Dow Chemical CompanyInventors: Chester E. Pawloski, David J. Wampfler, Donna J. Fielding
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Patent number: 4824603Abstract: Amphoteric and zwitter-ionic phosphate surfactants corresponding to the following formula ##STR1## (a) in which R.sup.1 is a C.sub.6 -C.sub.22 alkyl group, a group R.sup.4 (OC.sub.n H.sub.2n).sub.x --, where n=2 to 4, x=1 to 6, and R.sup.4 is a C.sub.6 -C.sub.22 alkyl group, or a group R.sup.5 --CONH(CH.sub.2).sub.m, where R.sup.5 is a C.sub.5 -C.sub.21 group and m=2 to 4; R.sup.2 is hydrogen; and R.sup.3 is a C.sub.1 -C.sub.4 alkyl group or a group --(C.sub.n H.sub.2n O).sub.x --H or --(C.sub.n H.sub.2n O).sub.x --PO.sub.3 H.sub.2, where n=2 to 4 and x=1 to 6, or(b) in which R.sup.1 is a C.sub.1 -C.sub.4 alkyl group or a C.sub.2 -C.sub.4 2-hydroxyalkyl group; R.sup.2 is a C.sub.6 -C.sub.22 alkyl group; and R.sup.3 is as defined above.to mixtures thereof with correspondingly substituted phosphate surfactants corresponding to formula (I), in which the --PO.sub.3 H.sub.2 group or groups are replaced by hydrogen; and to neutral and basic salts of the foregoing.Type: GrantFiled: October 28, 1987Date of Patent: April 25, 1989Assignee: Henkel Kommanditgesellschaft auf AktienInventors: Hinrich Moller, Ulrich Zeidler
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Patent number: 4774348Abstract: Included is a process to prepare a halogenated phosphorate-containing product comprising serially contacting (a) a triol with a phosphorus trihalide, (b) a halogenating agent and (c) an oxirane, under conditions sufficient to prepare the halogenated phosphorate-containing product. For example, 2-methyl-2-(hydroxymethyl)-1,3-propanediol, phosphorus trichloride, bromine and ethylene oxide can be employed to prepare a mixture of (2,2-bis(bromomethyl)propyl)(2-bromoethyl)(2-chloroethyl) phosphorate and (2-bromoethyl)bis(2-chloroethyl)phosphorate.Type: GrantFiled: April 8, 1986Date of Patent: September 27, 1988Assignee: The Dow Chemical CompanyInventor: Chester E. Pawloski
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Patent number: 4739091Abstract: Included is a process for the preparation of a ((neocarbyl)contrasting-halo-substituted)phosphorate comprising serially contacting (1) a phosphorus trihalide with a neocarbyl alcohol; (2) an oxirane; (3) a halogenating agent; and (4) an oxirane, under conditions sufficient to prepare the ((neocarbyl)contrasting-halo-substituted)phosphorate.The phosphate can be very pure.Also included is a method for improving a production characteristic of flame-retardant polyurethanes. The characteristic may be selected from the group consisting of (1) processability; (2) scorch; (3) odor; (4) flame-retardant efficiency; and (5) combinations thereof. The method comprises incorporation into a polyurethane an amount effective to reduce combustibility of the foregoing phosphorate flame retardant under conditions sufficient to improve said characteristic. Also included is the flame-retardant polyurethane composition of said method.Type: GrantFiled: March 24, 1986Date of Patent: April 19, 1988Assignee: The Dow Chemical CompanyInventor: Chester E. Pawloski