Abstract: The present disclosure relates to pantothenate derivatives for the treatment of neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment of neurologic disorders.

Abstract: Dye reagents useful in labeling biological materials are provided along with methods for their use.

Abstract: The present invention relates to a method for preparing phosphoramides having a glass transition temperature in one embodiment of at least about 0° C., in another embodiment of at least about 10° C., and in still another embodiment of at least about 20° C., the phosphoramides being substantially free of acidic, basic, or halide impurities, or their precursors. The invention also relates to resin compositions comprising at least one thermoplastic resin and at least one phosphoramide having a glass transition temperature of at least about 0° C., wherein the phosphoramide is prepared by the method of the invention.

Abstract: This invention provides a halogen-free flame retardant which advantageously has a high melting point and a low volatility and does not impair the inherent properties of resins. The flame retardant of the invention is a phosphazene compound crosslinked with a crosslinking group such as a phenylene group, wherein each of the crosslinking groups is interposed between the two oxygen groups left after the elimination of phenyl groups from the phosphazene compound; the crosslinked phenoxyphosphazene compound does not have any free hydroxyl groups (derived from crosslinking groups); and the amount of the phenyl groups in the crosslinked compound is 50 to 99.9%, based on the total number of the phenyl groups in the phosphazene compound.

Abstract: Incorporation of phosphate and phosphonate units into the side groups of aryloxyphosphazenes, at both the polymer and cyclic trimer levels, is disclosed. Phosphorylated cyclic trimers are utilized as flame-retardant additives to polystyrene.

Abstract: A process for producing a polyorganophosphazene from a polyhalophosphazene. The polyhalophosphazene is reacted with a metal salt of an alkyl ester of hydroxybenzoic acid wherein the metal salt of the alkyl ester of hydroxybenzoic acid is contained in a homogeneous melt solution. The reaction of the polyhalophosphazene with the metal salt of an alkyl ester of hydroxybenzoic acid produces a macromolecular substituted polymer, which is reacted with a base to hydrolyze the polymer and produce the desired polyorganophosphazene product.

Abstract: A process to prepare a multidentate phosphite compound according to the general formula (1) ##STR1## in which n is 2-6, R is an n-valent organic group and R.sup.1 and R.sup.2 are fused aromatic ring systems with 2 or more rings, which rings are substituted on the ortho position relative to the oxygen atom only with hydrogen, by first preparing a phosphorochloridite compound from a R.sup.1 --OH and R.sup.2 --OH alcohol compound and a phosphorus chloride compound and subsequently contacting the phosphorochloridite compound with an alcoholic compound according to R--(OH).sub.n, wherein the phosphorochloridite is prepared by performing the two steps in a solvent:a) contacting a compound with the general formula: ##STR2## in which R.sup.3 and R.sup.4 are C.sub.1 -C.sub.4 alkyl groups, with the R.sup.1 OH and R.sup.2 OH compounds, andb) contacting the resulting compound of step (a) which has the formula (3): ##STR3## with HY, wherein Y is a halogen.

Abstract: New phosphazene derivatives, fully substituted by aromatic groups and perfluoropolyethereal chains, are utilized as stabilizers for oils and greases based on perfluoropolyethers. Such derivatives inhibit the degradation process affecting the perfluoropolyethereal chains when these are subjected to high temperatures in an oxidizing atmosphere and in the presence of metals, such as for example aluminium, titanium, vanadium and their alloys, or steels.

Abstract: Organopolysiloxane oils and gums are produced by the condensation of silanol-terminated organosiloxane in the presence of an effective amount of a peralkylated phosphazene base as a catalyst and at reduced pressure.

Abstract: Fluorescent reagents possessing an activated phosphate for the convenient covalent coupling to the 5'-hydroxyl of oligonucleotides. A class of 5.dbd.-fluorescence-tagged oligonucleotides is also disclosed.

Abstract: A process for preparing a phosphonitrile compound having a substituted hydroxyl group by making use of a phosphonitrile chloride oligomer and an alcohol as the starting materials, which comprises:(1) a first step of reacting said phosphonitrile chloride oligomer with said alcohol in a specific amount ratio of the active chlorine contained in said phosphonitrile chloride oligomer relative to the alcohol in the presence of a specific amount of a tertiary amine at a specific temperature, thereby substituting a specific amount of said active chlorine by a substituted alkoxy group,(2) a second step of elevating the temperature of the reaction mixture obtained in the first step to a specific temperature to cause a condensation reaction through the elimination of R--Cl, and(3) a third step of adding an alcohol in a specific amount ratio relative to said active chlorine which remains at the stage of completion of the second step, to the reaction system, and making said remaining active chlorine react with said alcoho