Abstract: The present invention relates to novel phosphorus-containing compounds with polymeric chains, and methods of making and using the same. In part, subject compositions containing phosphorus-containing compounds with polymeric chains and a therapeutic agent, and methods of making and using the same, are described. Certain of the subject compositions exhibit reverse thermal gelation.
Type:
Application
Filed:
July 24, 2012
Publication date:
January 24, 2013
Applicant:
Eisai Inc.
Inventors:
Keith Branham, Mahesh V. Chaubal, James P. English, Donna Hall, Zhong Zhao
Abstract: The present invention provides a novel phosphoric compound, a method for preparing the same, and a thermoplastic resin composition including the same. A thermoplastic resin composition comprising the phosphoric compound of the present invention can have excellent flame retardancy, and can be eco-friendly because the phosphoric compound does not generate toxic gas during molding or combustion.
Abstract: A flame retardant composition is produced by mixing a flammable organic material with an organic phosphorus-inorganic phosphorus oxyacid compound or its salts. The organic phosphorus-inorganic phosphorus oxyacid compounds are produced by reacting an organic phosphorus compound with an inorganic phosphorus oxyacid. The organic phosphorus-inorganic phosphorus oxyacid compound may be reacted with a basic salt forming compound. The flammable organic material such as thermoplastic resins are made less flammable by melting-kneading the flammable material with the organic phosphorus-inorganic phosphorus oxyacid compound or it's basic salt, carbonization auxiliaries, a metal-containing compound having a carbonization acceleration effect, a comb-like polymer and a filler.
Abstract: A bis(pentaerythritol phosphate alcohol) alkylphosphonate compound, such as one comprising an alkyl group of from about one to four carbon atoms, preferably bis(pentaerythritol phosphate alcohol) methylphosphonate, is a flame retardant compound. Such a compound can be prepared by the transesterification of a diphenyl alkyl phosphonate carrying the desired alkyl group with pentaerythritol phosphate alcohol. An alternative process of preparation comprises the reaction of pentaerythritol phosphate alcohol, a trialkylamine, and an alkylphosphonic dihalide.
Abstract: The compounds of the formula (I)H.sub.3 C--P(.dbd.O)(OR)--CH.sub.2 CH.sub.2 COOR (I)in which R is (C.sub.4 -C.sub.8)alkyl are suitable as intermediates for the preparation of herbicides.They can be prepared according to the invention, in which compounds of the formula (II)CH.sub.3 P(.dbd.O) (Cl)--CH.sub.2 CH.sub.2 COCl (II)are reacted with an alcohol of the formula ROH or a corresponding alcohol mixture at -30.degree. to +50.degree. C.
Abstract: Process for the preparation of compounds of the formula ##STR1## where R is (C.sub.1 -C.sub.4)alkyl, which comprises reacting a compound of the formula II ##STR2## with an alcoholate of the formula IIIMet-OR (III)where Met is Na or K and R has the abovementioned meaning, at temperature from -30.degree. C. to +10.degree. C.
Type:
Grant
Filed:
October 18, 1990
Date of Patent:
October 6, 1992
Assignee:
Hoechst Aktiengesellschaft
Inventors:
Harald Knorr, Hilmar Mildenberger, Hans J. Nestler
Abstract: The present invention is directed to the preparation of certain phosphorothioates and phosphonoates by means of a process which employs a three-phase system for the reaction of an alkali metal or alkaline earth metal phenate, pyridinate or pyrimidinate with a phosphorochloridothioate or phosphorochloridate under alkaline conditions and in the presence of tertiary amine and quarternary ammonium salt co-catalyst, but in the absence of both a hydrocarbon or chlorinated hydrocarbon solvent and a surfactant.
Abstract: Thiophosphonate compounds having the formula ##STR1## in which R is alkyl, haloalkyl or aryl; X is chloro or SR.sub.2 ; R.sub.1 is alkyl or aryl; and when X is SR.sub.2 then R.sub.2 is a group identical to R.sub.1, or R.sub.1 and R.sub.2 taken together form an optionally alkyl-substituted polymethylene group, are prepared by reaction of a thiophosphonodichloride with a mercaptan in the presence of a catalytic amount of a quaternary ammonium or phosphonium salt, a tertiary amine or hydrohalide thereof or an alkali metal halide combined with a Crown ether, in the substantial absence of a base.
Type:
Grant
Filed:
December 12, 1988
Date of Patent:
September 11, 1990
Assignee:
ICI Americas Inc.
Inventors:
Jeffrey D. Robbins, Richard D. Gless, Jr.
Abstract: Process for preparing an O-alkyl S-(alpha-branched alkyl) alkylphosphonothioate of formula: ##STR1## with R and R.sub.1 =alkyl having 1 to 8 C. R.sub.2 =alpha-branched alkyl having 3 to 8 C.It consists in reacting an O-(alkyl)alkylphosphonic acid halide with an alkyl mercaptan HSR.sub.2 in an organic medium, in the presence of an acceptor for acid and a smaller amount of an auxiliary base.Process useful for preparing insecticidal and nematocidal products.
Type:
Grant
Filed:
August 28, 1985
Date of Patent:
January 19, 1988
Assignee:
Rhone-Poulenc Agrochimie
Inventors:
Jean-Michel Brochard, Stanley T. D. Gough
Abstract: Phosphobrominated polyetherpolyols which contain in their molecule oxyalkylene radicals bound to phosphorus atoms in the phosphate or phosphonate state and 1,4-dioxy-2,3-dibromo-2-butylene radicals in which the ratio of the total number of oxyalkylene radicals to the total number of phosphorus atoms is equal to at least 7.These polyetherpolyols can be used as flame-retarding reactive additives in the manufacture of flame-retardant flexible polyurethane foams involving polyetherpolyols, the foams possessing good comfort-conferring properties.
Abstract: Dialkylphenylphosphonates are prepared by the reaction of a metal alkoxide with a phenyl phosphonic dihalide. The reactants are combined to give a temperature rise to 60.degree. C. within 15 minutes, resulting in improved yields and assay of product.