Rings Bonded Directly To Each Other In Acid Moiety Patents (Class 560/102)
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Patent number: 11020411Abstract: Disclosed herein are compounds comprising dicarba-closo-dodecaborane. The compounds can be, for example, estrogen receptor beta (ER?) agonists. In some examples, the compounds can be selective ER? agonists. Also provided herein are methods of treating, preventing, or ameliorating cancer in a subject, suppressing tumor growth in a subject, treating an inflammatory disease in a subject, treating a neurodegenerative disease in a subject, treating a psychotropic disorder in a subject, or a combination thereof by administering to a subject a therapeutically effective amount of one or more of the compounds or compositions described herein, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: September 19, 2016Date of Patent: June 1, 2021Assignees: OHIO STATE INNOVATION FOUNDATION, INSTITUTE OF MOLECULAR GENETICS AS CR, V.V.I.Inventors: Werner Tjarks, Petr Bartunek, David Sedlak
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Patent number: 10106499Abstract: Novel processes for preparing cyclopenta[b]naphthalenol derivatives of Formula 1 which are useful for the synthesis of corresponding benzindene prostaglandins are provided. The present invention also relates to novel intermediates prepared from the processes.Type: GrantFiled: November 10, 2017Date of Patent: October 23, 2018Assignee: CHIROGATE INTERNATIONAL INC.Inventors: Shih-Yi Wei, Shih-Hsun Su
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Patent number: 10005771Abstract: The present invention relates to novel compounds having ?2 adrenergic agonist and M3 muscarinic antagonist dual activity, to pharmaceutical compositions containing them, to the process for their preparation and to their use in respiratory therapies.Type: GrantFiled: September 25, 2015Date of Patent: June 26, 2018Assignee: Almirall, S.A.Inventors: Carlos Puig Duran, Jose Aiguade Bosch, Silvia Gual Roig, Maria Prat Quiñones
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Publication number: 20150140350Abstract: Provided are compounds of the following: wherein R1 is a saturated or unsaturated cyclic hydrocarbon optionally substituted with an alkyl and/or an OXO-ester, and R2 is a C4 to C14 hydrocarbyl, preferably the residue of a C4 to C14 OXO-alcohol. Also provided are processes for making the compounds and plasticized polymer compositions containing said compounds.Type: ApplicationFiled: October 16, 2014Publication date: May 21, 2015Inventors: Jihad M. Dakka, Lorenzo C. DeCaul, Christine A. Costello, Edmund J. Mozeleski, Pierre Osterrieth, Stephen Zushma, Allen D. Godwin, Diana Smirnova, Catherine A. Faler, Victor Deflorio, Didier Naert
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Patent number: 9000209Abstract: A method of synthesis of para-substituted benzoate esters and acids is provided, wherein the para-substituted regioisomer is obtained substantially free of the meta-substituted impurity, the method comprising contacting a coumalate ester or acid and an unactivated alkene at elevated temperature in the presence of a metal oxidation catalyst and an oxidant. The metal oxidation catalyst can be palladium, such as palladium on carbon, and the oxidant can be the oxygen gas in ambient air. The reaction can be carried out without solvent or in high boiling hydrocarbon solvents such as mesitylene. When the unactivated alkene is a monosubstituted alkene, yields of at least about 50 or 60% of para-substituted ester and acid products, respectively, are obtained, substantially free of the regioisomeric meta-substituted impurity.Type: GrantFiled: June 21, 2012Date of Patent: April 7, 2015Assignee: Iowa State University Research Foundation, Inc.Inventor: George A. Kraus
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Patent number: 8987500Abstract: The present invention relates to novel 4-biphenyl-substituted pyrazolidine-3,5-dione derivatives of the formula (I) in which A, D, G, W, X, Y and Z are as defined above, to a plurality of processes for the preparation and to their use as pesticides and/or herbicides and/or microbicides. Moreover, the invention relates to selective herbicidal compositions comprising both the 4-biphenyl-substituted pyrazolidine-3,5-dione derivatives of the formula (I) and a crop plant compatibility-improving compound.Type: GrantFiled: July 29, 2013Date of Patent: March 24, 2015Assignee: Bayer CropScience AGInventors: Reiner Fischer, Thomas Bretschneider, Ernst Rudolf F. Gesing, Dieter Feucht, Karl-Heinz Kuck, Peter Lösel, Olga Malsam, Christian Arnold, Thomas Auler, Martin Jeffrey Hills, Heinz Kehne
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Publication number: 20150073092Abstract: Methods for forming rosin-derived cationic compounds are provided. The method can include attaching a cationic group to a conjugated diene on a hydrophenathrene-based ring of a resin acid (e.g., levopimaric acid, abietic acid, dehydroabietic acid, or a mixture thereof) to form a rosin-derived cationic compound. Attaching the cationic group to the conjugated diene on the hydrophenathrene-based ring of the resin acid can be achieved via a Diels-Alder reaction of a dienophile with the hydrophenathrene-based ring of the resin acid. Rosin-derived cationic compounds are also provided. The rosin-derived cationic compound can include a cationic group attached to a conjugated diene on a hydrophenathrene-based ring of a resin acid, wherein the rosin-derived cationic compound further comprises a carboxylic acid group.Type: ApplicationFiled: November 17, 2014Publication date: March 12, 2015Inventors: Chuanbing Tang, Jifu Wang, Alan W. Decho, Yung Pin Chen
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Publication number: 20150065743Abstract: Methods for the selective borylation of arenes, including arenes substituted with an electron-withdrawing group (e.g., 1-chloro-3-fluoro-2-substituted benzenes) are provided. The methods can be used, in some embodiments, to efficiently and regioselectively prepare borylated arenes without the need for expensive cryogenic reaction conditions.Type: ApplicationFiled: September 5, 2014Publication date: March 5, 2015Inventors: Milton R. Smith, III, Robert E. Maleczka, JR., Hao Li, Chathurika Jayasundara, Jossian Oppenheimer, Dmitrijs Sabasovs
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Patent number: 8969611Abstract: Disclosed are ester compounds of the formulae wherein Rc is alkylene, arylene, arylalkylene, or alkylarylene as further defined herein, Rd is alkylene, arylene, arylalkylene, or alkylarylene as further defined herein, and m and n are integers representing the numbers of repeat monomer units. The materials are suitable for use in inks and other applications.Type: GrantFiled: April 2, 2014Date of Patent: March 3, 2015Assignee: Xerox CorporationInventors: Rina Carlini, Adela Goredema
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Patent number: 8952249Abstract: 1,4 fullerene deriatives useful for solar cells are provided, where their structures allow for straightforward functionalizations to tune their properties in terms of solubility and LUMO energy levels.Type: GrantFiled: June 16, 2011Date of Patent: February 10, 2015Assignee: The Regents of the University of CaliforniaInventors: Alessandro Varotto, Fred Wudl, Jang Jo
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Publication number: 20150034874Abstract: Provided is a novel material included in a liquid crystal composition that can be used in various liquid crystal display devices. A trifluorophenyl derivative represented by General Formula (G1). In General Formula (G1), Ar1 represents an arylene group having 6 to 12 carbon atoms, a cycloalkylene group having 3 to 12 carbon atoms, or a cycloalkenylene group having 3 to 12 carbon atoms; m represents 1 or 2; and R1 represents hydrogen, an alkyl group having 2 to 11 carbon atoms, or an alkoxy group having 2 to 11 carbon atoms.Type: ApplicationFiled: July 28, 2014Publication date: February 5, 2015Inventors: Momoko KATO, Yuko KAWATA, Yasuhiro NIIKURA, Tetsuji ISHITANI
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Publication number: 20140378696Abstract: The present invention relates to a process for the preparation of a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein R represents one or more groups independently selected from fluorine, chlorine, bromine, and iodine, said process comprising the cyclopropanation of a compound of formula (II) with ethylene carbonate or ethylene sulfate: wherein X is chlorine, bromine, iodine or a triflate group (CF3SO3) or a group ?wherein R is as defined above and G is —CN or —COOR2 wherein R2 is a C1-C4 straight or branched alkyl chain.Type: ApplicationFiled: June 23, 2014Publication date: December 25, 2014Applicant: CHIESI FARMACEUTICI S.p.AInventors: Massimo VERZINI, Livius Cotarca, Alberto Guidi, Alfonso Melloni, Paolo Maragni
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Publication number: 20140378697Abstract: This invention relates to process for producing biphenyl esters, the process comprising: (a) contacting a feed comprising toluene, xylene or mixtures thereof with hydrogen in the presence of a hydroalkylation catalyst to produce a hydroalkylation reaction product comprising (methylcyclohexyl)toluene, wherein the hydroalkylation catalyst comprises: 1) binder present at 40 wt % or less (based upon weight of final catalyst composition), 2) a hydrogenation component present at 0.2 wt % or less (based upon weight of final catalyst composition), and 3) an acidic component comprising a molecular sieve having a twelve membered (or larger) ring pore opening, channel or pocket and a largest pore dimension of 6.Type: ApplicationFiled: June 25, 2014Publication date: December 25, 2014Inventors: Emiel de Smit, Neeraj Sangar, Michael Salciccioli, Jihad M. Dakka, Lorenzo C. DeCaul, Terry E. Helton, Scott J. Weigel
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Publication number: 20140319404Abstract: The present invention relates to the use of certain substituted fullerenes in optoelectronic devices, preferably in photovoltaic cells, preferably in organic photovoltaic cells especially preferred in a two-component electron-selective buffer layer of an organic photovoltaic cell to improve the efficiency of solar cells for energy generation.Type: ApplicationFiled: July 3, 2012Publication date: October 30, 2014Applicant: LANXESS DEUTSCHLAND GMBHInventors: Roman Evgenievich Levin, Alexey Borisovich Kornev, Pavel Anatolyevich Troshin, Vladimir Fedorovich Razumov
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Publication number: 20140316155Abstract: In a process for producing methyl-substituted biphenyl compounds, a feed comprising at least one aromatic hydrocarbon selected from the group consisting of toluene, xylene and mixtures thereof is contacted with hydrogen in the presence of a hydroalkylation catalyst under conditions effective to produce a hydroalkylation reaction product comprising (methylcyclohexyl)toluenes and/or (dimethylcyclohexyl)xylenes together with dialkylated C21+ compounds. At least part of the dialkylated C21+ compounds is then removed from the hydroalkylation reaction product to produce a dehydrogenation feed; and at least part of the dehydrogenation feed is dehydrogenated in the presence of a dehydrogenation catalyst under conditions effective to produce a dehydrogenation reaction product comprising a mixture of methyl-substituted biphenyl compounds.Type: ApplicationFiled: March 7, 2014Publication date: October 23, 2014Inventors: Jihad M. Dakka, Lorenzo C. DeCaul, Victor DeFlorio
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Publication number: 20140288324Abstract: A method of synthesis of para-substituted benzoate esters and acids is provided, wherein the para-substituted regioisomer is obtained substantially free of the meta-substituted impurity, the method comprising contacting a coumalate ester or acid and an unactivated alkene at elevated temperature in the presence of a metal oxidation catalyst and an oxidant. The metal oxidation catalyst can be palladium, such as palladium on carbon, and the oxidant can be the oxygen gas in ambient air. The reaction can be carried out without solvent or in high boiling hydrocarbon solvents such as mesitylene. When the unactivated alkene is a monosubstituted alkene, yields of at least about 50 or 60% of para-substituted ester and acid products, respectively, are obtained, substantially free of the regioisomeric meta-substituted impurity.Type: ApplicationFiled: June 21, 2012Publication date: September 25, 2014Inventor: George A. Kraus
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Publication number: 20140275609Abstract: In a process for producing methyl-substituted biphenyl compounds, a feed comprising at least one aromatic hydrocarbon selected from the group consisting of toluene, xylene and mixtures thereof is contacted with hydrogen in the presence of a hydroalkylation catalyst under conditions effective to produce a hydroalkylation reaction product comprising (methylcyclohexyl)toluenes and/or (dimethylcyclohexyl)xylenes. At least part of the hydroalkylation reaction product is then dehydrogenated in the presence of a dehydrogenation catalyst under conditions effective to produce a dehydrogenation reaction product comprising a mixture of methyl-substituted biphenyl compounds.Type: ApplicationFiled: March 7, 2014Publication date: September 18, 2014Inventors: Jihad M. Dakka, Lorenzo C. DeCaul
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Patent number: 8835494Abstract: Pro-drugs of 1-(2-halo-biphenyl-4-yl)alkanecarboxylic acids are useful for preventing and/or treating neurodegenerative diseases, improving cognitive function and treating cognitive impairment.Type: GrantFiled: April 3, 2013Date of Patent: September 16, 2014Assignee: Chiesi Farmaceutici S.p.A.Inventors: Bruno Pietro Imbimbo, Luca Raveglia
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Publication number: 20140256666Abstract: The present invention describes single drug entities, formed by connecting an antibiotic moiety via a linker with a non-steroidal anti-inflammatory drug (NSAID) moiety. Upon topical application to the eye, the conjugate hybrid would undergo enzymatic and/or hydrolytic cleavage to release the individual antibiotic and NSAID drug.Type: ApplicationFiled: March 6, 2014Publication date: September 11, 2014Applicant: Allergan, Inc.Inventors: Santosh C. Sinha, Smita S. Bhat, Ken Chow, LIMING WANG, MICHAEL E. GARST, MAYSSA ATTAR, BRANDON D. SWIFT
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Publication number: 20140212666Abstract: Provided are compounds of the following: wherein R1 is a saturated or unsaturated cyclic hydrocarbon optionally substituted with an alkyl and/or an OXO-ester, and R2 is a C4 to C14 hydrocarbyl, preferably the residue of a C4 to C14 OXO-alcohol. Also provided are processes for making the compounds and plasticized polymer compositions containing said compounds.Type: ApplicationFiled: January 27, 2014Publication date: July 31, 2014Inventors: Jihad M. Dakka, Lorenzo C. DeCaul, Christine A. Costello, Edmund J. Mozeleski, Pierre Osterrieth, Stephen Zushma, Allen D. Goodwin, Diana Smirnova, Catherine A. Faler, Victor Deflorio, Didier Naert
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Publication number: 20140213709Abstract: Provided are compounds of the following: wherein R1 is a saturated or unsaturated cyclic hydrocarbon optionally substituted with an alkyl and/or an OXO-ester, and R2 is the residue of a C4 to C14 OXO-alcohol. Also provided are processes for making the compounds and plasticized polymer compositions containing said compounds.Type: ApplicationFiled: January 28, 2013Publication date: July 31, 2014Applicant: EXXONMOBIL RESEARCH AND ENGINEERING COMPANYInventor: EXXONMOBIL RESEARCH AND ENGINEERING COMPANY
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Publication number: 20140163174Abstract: Methods for forming rosin-derived cationic compounds are provided. The method can include attaching a cationic group to a conjugated diene on a hydrophenathrene-based ring of a resin acid (e.g., levopimaric acid, abietic acid, dehydroabietic acid, or a mixture thereof) to form a rosin-derived cationic compound. Attaching the cationic group to the conjugated diene on the hydrophenathrene-based ring of the resin acid can be achieved via a Diels-Alder reaction of a dienophile with the hydrophenathrene-based ring of the resin acid. Rosin-derived cationic compounds are also provided. The rosin-derived cationic compound can include a cationic group attached to a conjugated diene on a hydrophenathrene-based ring of a resin acid, wherein the rosin-derived cationic compound further comprises a carboxylic acid group.Type: ApplicationFiled: December 10, 2013Publication date: June 12, 2014Inventors: Chuanbing Tang, Jifu Wang, Alan W. Decho, Yung Pin Chen
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Publication number: 20140066647Abstract: The present subject matter relates to methods for the synthesis of [6,6]-phenyl-C61-butyric acid methyl ester (PCBM) and fullerene derivatives in a yield of at least 40%.Type: ApplicationFiled: August 31, 2012Publication date: March 6, 2014Applicant: NANO AND ADVANCED MATERIALS INSTITUTE LIMITEDInventors: Ka Ming NG, Jianle ZHUANG, Nai Wen TSENG, Yong YU
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Patent number: 8664428Abstract: The present invention relates to a novel process for preparing substituted and unsubstituted (2,4-dimethylbiphenyl-3-yl)acetic acids and their esters of the formula (I) using homogeneous and heterogeneous palladium catalysts, and also the intermediates 4-tert-butyl-2,6-dimethylphenylacetic acid and 4-tert-butyl-2,6-dimethylmandelic acid, and to processes for their preparation.Type: GrantFiled: June 25, 2010Date of Patent: March 4, 2014Assignee: Bayer CropScience AGInventors: Reiner Fischer, Thomas Himmler, Wolfgang Joerges, Werner Lindner, Wahed Ahmed Moradi
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Publication number: 20140039215Abstract: The present invention relates to novel 4-biphenyl-substituted pyrazolidine-3,5-dione derivatives of the formula (I) in which A, D, G, W, X, Y and Z are as defined above, to a plurality of processes for the preparation and to their use as pesticides and/or herbicides and/or microbicides. Moreover, the invention relates to selective herbicidal compositions comprising both the 4-biphenyl-substituted pyrazolidine-3,5-dione derivatives of the formula (I) and a crop plant compatibility-improving compound.Type: ApplicationFiled: July 29, 2013Publication date: February 6, 2014Applicant: Bayer Intellectual Property GmbHInventors: Reiner FISCHER, Thomas BRETSCHNEIDER, Ernst Rudolf F. GESING, Dieter FEUCHT, Karl-Heinz KUCK, Peter LÖSEL, Olga MALSAM, Christian ARNOLD, Thomas AULER, Martin Jeffrey HILLS, Heinz KEHNE
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Publication number: 20140031545Abstract: Processes for making an organozinc reagents are disclosed comprising reacting (A) organomagnesium or organozinc complexes with (B) at least one coordination compound comprising one or more carboxylate groups and/or alcoholate groups and/or tertiary amine groups, optionally in combination with zinc ions and/or lithium ions and/or halide ions, wherein the halide ions are selected from chloride, bromide and iodide, the organozinc complex comprises an aryl group, a heteroaryl group or a benzyl group when the coordinating compound is a chelating polyamine, and the reaction is conducted in the presence of zinc complexed with at least one coordinating compound when reactant (A) comprises at least one organomagnesium complex. The resulting organozinc reagents may optionally be isolated from solvents to obtain a solid reagent. The reagents may be used for making organic compounds via Negishi cross-coupling reactions or via aldehyde and/or ketone oxidative addition reactions.Type: ApplicationFiled: December 21, 2011Publication date: January 30, 2014Applicant: LUDWIG-MAXIMILIAN-UNIVERSITAT MUNCHENInventors: Paul Knochel, Sebastian Bernhardt, Georg Manolikakes
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Patent number: 8637496Abstract: The invention relates to the use of compounds having a monogalactosyldiacylglycerol (MGDG) synthase inhibitory activity as herbicide or algaecide, and to herbicide and algaecide compositions containing at least one of these compounds.Type: GrantFiled: June 2, 2008Date of Patent: January 28, 2014Assignees: Commissariat a l'Energie Atomique, Centre National de la Recherche ScientifiqueInventors: Anne-Laure Bonneau, Cyrille Botte, Michael Deligny, Nadia Saidani, Hélène Hardre, Bernard Rousseau, Roman Lopez, Eric Marechal
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Patent number: 8617789Abstract: A photoacid generator represented by the following formula (1), a method for producing the photoacid generator, and a resist composition containing the photoacid generator are provided. wherein in the formula (1), Y1, Y2, X, R1, R2, n1, n2 and A+ have the same meanings as defined in the detailed description of the invention. The photoacid generator can maintain an appropriate contact angle at the time of ArF liquid immersion lithography, can reduce defects occurring during liquid immersion lithography, and has excellent solubility in resist solvents and excellent compatibility with resins. Furthermore, the photoacid generator can be produced by an efficient and simple method using an epoxy compound that is industrially easily available.Type: GrantFiled: February 7, 2012Date of Patent: December 31, 2013Assignee: Korea Kumho Petrochemical Co., Ltd.Inventors: Jung Hoon Oh, Jin Bong Shin, Tae Gon Kim, Dong Chul Seo
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Patent number: 8592622Abstract: A polymerizable fluorine-containing compound represented by formula (1), wherein R1 represents a polymerizable double-bond containing group, R2 represents an acid-labile protecting group, R3 represents a fluorine atom or fluorine-containing alkyl group, and W represents a bivalent linking group. This compound can provide a fluorine-containing polymer compound that has a weight-average molecular weight of 1,000-1,000,000 and contains a repeating unit represented by formula (2), wherein R2, R3 and W are defined as above, each of R4, R5 and R6 independently represents a hydrogen atom, fluorine atom or monovalent organic group, at least two of R4, R5 and R6 may be combined to form a ring. This polymer compound can provide a resist composition capable of forming a pattern that is transparent to exposure light and superior in rectangularity.Type: GrantFiled: January 4, 2011Date of Patent: November 26, 2013Assignee: Central Glass Company, LimitedInventors: Yoshimi Isono, Jonathan Joachim Jodry, Satoru Narizuka
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Publication number: 20130267592Abstract: Pro-drugs of 1-(2-halo-biphenyl-4-yl)alkanecarboxylic acids are useful for preventing and/or treating neurodegenerative diseases, improving cognitive function and treating cognitive impairment.Type: ApplicationFiled: April 3, 2013Publication date: October 10, 2013Applicant: Chiesi Farmaceutici S.p.A.Inventors: Bruno Pietro IMBIMBO, Luca Raveglia
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Patent number: 8541398Abstract: The present invention relates to derivatives of non-steroidal anti-inflammatory drugs (NSAIDs) having improved anti-inflammatory properties useful in the treatment of inflammation, pain and fever. More particularly, NSAIDs are derivatized with a hydrogen sulfide (H2S) releasing moiety to produce novel anti-inflammatory compounds having reduced side effects.Type: GrantFiled: February 11, 2010Date of Patent: September 24, 2013Assignee: Antibe Therapeutics Inc.Inventors: John L. Wallace, Giuseppe Cirino, Vincenzo Santagada, Giuseppe Caliendo
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Patent number: 8530517Abstract: The present invention relates to new retinoid derivatives of formula I and to pharmaceutical compositions containing them for the treatment of patients affected by pathologies such as arthritic conditions, tumors, metastatic cancer, diabetic retinopathy, psoriasis, chronic inflammatory diseases or atherosclerosis.Type: GrantFiled: December 21, 2009Date of Patent: September 10, 2013Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.Inventors: Walter Cabri, Giuseppe Giannini, Gianfranco Battistuzzi, Domenico Alloatti, Claudio Pisano, Sabrina Dallavalle, Tiziana Brunetti
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Patent number: 8530689Abstract: The invention concerns processes for the synthesis of a compound of the formula: wherein: R1 and R2 are each, independently, C1-C12 alkyl, CO2R3, OR4, R5(OR6), or C6-C18 aryl; R3-R6 are each, independently, C1-C12 alkyl or C6-C12 aryl; and n and m are each, independently, O or an integer from 1-5; said process comprising:—contacting a compound of the formula H0-R7-0H with BH3 and a compound of the formula in the presence of a nickel-containing catalyst to produce a first product, where R7 is a C2-C12 hydrocarbon group and X is a halogen, OMs or OTs;—contacting the first product in situ with a compound of the formula: in the presence of a nickel-containing catalyst to produce a compound of formula I, where Z is a halogen.Type: GrantFiled: April 30, 2009Date of Patent: September 10, 2013Assignee: The Trustees Of The University Of PennsylvaniaInventors: Virgil Percec, Brad Matthew Rosen, Daniela A. Wilson, Christopher J. Wilson
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Patent number: 8524939Abstract: Novel processes for preparing optically active cyclopentanones 1 which are useful for the preparation of benzindene Prostaglandins and novel cyclopentanones are provided. The invention also provides novel processes of preparing benzindene Prostaglandins and novel intermediates for benzindene Prostaglandins.Type: GrantFiled: August 24, 2011Date of Patent: September 3, 2013Assignee: Chirogate International Inc.Inventors: Shih-Yi Wei, Min-Kuan Hsu, Ming-Kun Hsu
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Patent number: 8524952Abstract: A modified dimethylnaphthalene formaldehyde resin obtained by modifying a polyfunctional dimethylnaphthalene formaldehyde resin having a constituent unit represented by the following general formula [1] in a molecule thereof with at least one member selected from the group consisting of a phenol represented by the following general formula [2], a naphthol represented by the following general formula [3] and a naphthol represented by the following general formula [4] provided that at least any of the naphthol represented by the general formula [3] or the naphthol represented by the general formula [4] must be included.Type: GrantFiled: March 19, 2012Date of Patent: September 3, 2013Assignee: Mitsubishi Gas Chemical Company, Inc.Inventors: Seiji Kita, Masashi Ogiwara, Mitsuharu Kitamura, Dai Oguro, Gou Higashihara
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Patent number: 8519177Abstract: A modified dimethylnaphthalene formaldehyde resin obtained by modifying a polyfunctional dimethylnaphthalene formaldehyde resin having a constituent unit represented by the following general formula [1] in a molecule thereof with at least one member selected from the group consisting of a phenol represented by the following general formula [2], a naphthol represented by the following general formula [3] and a naphthol represented by the following general formula [4] provided that at least any of the naphthol represented by the general formula [3] or the naphthol represented by the general formula [4] must be included.Type: GrantFiled: March 19, 2012Date of Patent: August 27, 2013Assignee: Mitsubishi Gas Chemical Company, Inc.Inventors: Seiji Kita, Masashi Ogiwara, Mitsuharu Kitamura, Dai Oguro, Gou Higashihara
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Publication number: 20130053581Abstract: Novel processes for preparing optically active cyclopentanones 1 which are useful for the preparation of benzindene Prostaglandins and novel cyclopentanones are provided. The invention also provides novel processes of preparing benzindene Prostaglandins and novel intermediates for benzindene Prostaglandins.Type: ApplicationFiled: August 24, 2011Publication date: February 28, 2013Inventors: Shih-Yi WEI, Min-Kuan Hsu, Ming-Kun Hsu
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Publication number: 20130018202Abstract: The present invention relates to novel 4-biphenyl-substituted pyrazolidine-3,5-dione derivatives of the formula (I) in which A, D, G, W, X, Y and Z are as defined above, to a plurality of processes for the preparation and to their use as pesticides and/or herbicides and/or microbicides. Moreover, the invention relates to selective herbicidal compositions comprising both the 4-biphenyl-substituted pyrazolidine-3,5-dione derivatives of the formula (I) and a crop plant compatibility-improving compound.Type: ApplicationFiled: January 11, 2012Publication date: January 17, 2013Applicant: Bayer CropScience AGInventors: Reiner Fischer, Thomas Bretschneider, Ernst Rudolf F. Gesing, Dieter Feucht, Karl-Heinz Kuck, Peter Lösel, Olga Malsam, Christian Arnold, Thomas Auler, Martin Jeffrey Hills, Heinz Kehne
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Patent number: 8278475Abstract: This invention relates to processes for the production of optically active 2-(disubstituted aryl)cyclopropylamine compounds and optically active 2-(disubstituted aryl) cyclopropane carboxamide compounds which are useful intermediates for the preparation of pharmaceutical agents, and in particular the compound [1S-(1?,2?,3?(1S*,2R*),5?]-3-[7-[2-(3,4-difluorophenyl)-cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)-cyclopentane-1,2-diol.Type: GrantFiled: August 26, 2011Date of Patent: October 2, 2012Assignee: AstraZeneca ABInventors: Masaru Mitsuda, Tadashi Moroshima, Kentaro Tsukuya, Kazuhiko Watabe, Masahiko Yamada
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Publication number: 20120214950Abstract: Methods for forming rosin-derived cationic compounds are provided. The method can include attaching a cationic group to a conjugated diene on a hydrophenathrene-based ring of a resin acid (e.g., levopimaric acid, abietic acid, dehydroabietic acid, or a mixture thereof) to form a rosin-derived cationic compound. Attaching the cationic group to the conjugated diene on the hydrophenathrene-based ring of the resin acid can be achieved via a Diels-Alder reaction of a dienophile with the hydrophenathrene-based ring of the resin acid. Rosin-derived cationic compounds are also provided. The rosin-derived cationic compound can include a cationic group attached to a conjugated diene on a hydrophenathrene-based ring of a resin acid, wherein the rosin-derived cationic compound further comprises a carboxylic acid group.Type: ApplicationFiled: February 15, 2012Publication date: August 23, 2012Applicant: UNIVERSITY OF SOUTH CAROLINAInventors: Chuanbing Tang, Jifu Wang, Alan W. Decho, Yung Pin Chen
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Publication number: 20120142915Abstract: This disclosure concerns a protected cyclopropylboronic acid comprising a substituted cyclopropyl group and a boronic ester group having a protecting group. The protecting group is an N-methyliminodiacetic acid (MIDA) group or MIDA-based group.Type: ApplicationFiled: December 1, 2011Publication date: June 7, 2012Inventors: Matthew Duncton, Rajinder Singh
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Publication number: 20120136167Abstract: This invention relates to processes for the production of optically active 2-(disubstituted aryl)cyclopropylamine compounds and optically active 2-(disubstituted aryl) cyclopropane carboxamide compounds which are useful intermediates for the preparation of pharmaceutical agents, and in particular the compound [1S-(1?,2?,3?(1S*,2R*),5?]-3-[7-[2-(3,4-difluorophenyl)-cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)-cyclopentane-1,2-diol.Type: ApplicationFiled: August 26, 2011Publication date: May 31, 2012Applicant: ASTRAZENECA ABInventors: Masaru Mitsuda, Tadashi Moroshima, Kentaro Tsukuya, Kazuhiko Watabe, Masahiko Yamada
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Publication number: 20120130097Abstract: The invention relates to a novel process for the preparation of certain cyclopropyl carboxylic acid esters and other cyclopropyl carboxylic acid derivatives; a novel process for the preparation of dimethylsulfoxonium methylide and dimethylsulfonium methylide; to the use of certain cyclopropyl carboxylic acid esters in a process for the preparation of intermediates that can be used in the synthesis of pharmaceutically active entities; and to certain intermediates provided by these processes.Type: ApplicationFiled: January 30, 2012Publication date: May 24, 2012Applicant: AstraZeneca ABInventors: Adrian Clark, Elfyn Jones, Ulf Larsson, Anna Minidis
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Patent number: 8148551Abstract: The invention relates to tricyclic aromatics of the general formula I in which A1, A2, A3, A4, Q1-Q2, R1, R2, X1, X2, X3, Z1, Z2, Z3, Z4, q, r, s, t and u have the meaning indicated, and to the use thereof as components of liquid-crystalline media and to an electro-optical display element containing same.Type: GrantFiled: December 29, 2006Date of Patent: April 3, 2012Assignee: Merck Patent Gesellschaft MIT Beschraenkter HaftungInventors: Rudolf Eidenschink, Holger Kretzschmann
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Publication number: 20120060926Abstract: The present invention discloses an inverted organic photovoltaic cell comprising a polymerizable fullerene interlayer adapted to enhance the device performance and lifetime. The polymerizable fullerene derivative comprises a fullerene core, a bridging functional group and a polymerizable functional group. The fullerene core can be either C60 or C70, and the bridging functional group comprises a cyclic hydrocarbon or a heterocyclic ring. The polymerizable functional group comprises a thermally polymerizable functional group or a photochemically polymerizable functional group.Type: ApplicationFiled: March 11, 2011Publication date: March 15, 2012Applicant: NATIONAL CHIAO TUNG UNIVERSITYInventors: CHAIN-SHU HSU, YEN-JU CHENG, CHAO-HSIANG HSIEH, PEI-JUNG LI
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Publication number: 20120016152Abstract: The invention relates to a process for the preparation of optionally substituted 4?-haloalkyl-biphenyl-2-carboxylic acid esters and to a process for the preparation of corresponding optionally substituted 4?-haloalkylbiphenyl-2-carboxylic acids.Type: ApplicationFiled: March 16, 2011Publication date: January 19, 2012Applicant: SALTIGO GMBHInventors: Michael Kreis, Alain Cotte, Antje Steinhaus, Lukas Gooßen, Thomas Knauber
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Patent number: 8092720Abstract: Polymer supported metal complex catalysts and methods of their preparation and use are described. The polymer supported metal complex catalysts can be obtained via ligand exchange reactions between polymer ligands and a metal complex having catalytic activity. For example, a polymer supported rhodium (II) complex catalyst can be prepared via ligand exchange reaction between an insoluble polymer and a rhodium (II) carboxylate complex, wherein the insoluble polymer is prepared by a copolymerization reaction of (i) a styrene derivative with a substituted carboxylic acid, (ii) a styrene, and (iii) a linear alkane with both ends substituted by vinylbenzyloxy groups. The polymer supported catalysts can be used to catalyze asymmetric carbene reactions such as C—H insertion reactions and the like with high catalytic activity, chemical selectivity, diastereoselectivity, and enantioselectivity.Type: GrantFiled: June 20, 2007Date of Patent: January 10, 2012Assignee: National University Corporation Hokkaido UniversityInventors: Shunichi Hashimoto, Masahiro Anada
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Publication number: 20110313189Abstract: 1,4 fullerene deriatives useful for solar cells are provided, where their structures allow for straightforward functionalizations to tune their properties in terms of solubility and LUMO energy levels.Type: ApplicationFiled: June 16, 2011Publication date: December 22, 2011Inventors: Allesandro Varotto, Fred Wudl, Jang Jo
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Publication number: 20110306499Abstract: The invention relates to novel compounds of the formula (I) in which W, X, Y, Z and CKE have the meanings given above, to a plurality of processes and intermediates for their preparation and to their use as pesticides and/or herbicides, and also to selective herbicidal compositions comprising, firstly, the compounds of the formula (I) and, secondly, at least one crop plant compatibility-improving compound. The invention further relates to the boosting of the action of crop protection compositions comprising compounds of the formula (I) through the additions of ammonium salts or phosphonium salts and optionally penetrants.Type: ApplicationFiled: November 22, 2007Publication date: December 15, 2011Applicant: Bayer CropScience AGInventors: Thomas Bretschneider, Reiner Fischer, Rolf Pontzen, Christian Arnold, Ulrich Görgens, Olga Malsam, Udo Reckmann, Erich Sanwald, Stefan Lehr, Jan Dittgen, Dieter Feucht, Martin Hills, Christopher Rosinger
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Patent number: 8076348Abstract: [Problem] To provide a compound which can be used in the prevention and/or treatment of diseases in which 5-HT2B receptor and 5-HT7 receptor are concerned, particularly in the treatment of irritable bowel syndrome (IBS) and/or prevention of migraine. [Means for Resolution] It was found that an acylguanidine derivative having a tricyclic structure or a pharmaceutically acceptable salt thereof has a strong antagonism to 5-HT2B receptor and 5-HT7 receptor. In addition, the compound of the present invention having antagonism to both of the receptors showed superior pharmacological action in comparison with the case of the single use of an antagonist selective for either one of the receptors. Based on the above, the compound of the present invention is useful in preventing and/or treating diseases in which 5-HT2B receptor and 5-HT7 receptor are concerned, particularly in treating irritable bowel syndrome (IBS) and/or preventing migraine.Type: GrantFiled: August 7, 2006Date of Patent: December 13, 2011Assignee: Astellas Pharma Inc.Inventors: Hiroyoshi Yamada, Hirotsune Itahana, Ayako Moritomo, Takaho Matsuzawa, Eisuke Nozawa, Shinobu Akuzawa, Koichiro Harada