Nitrogen In Acid Moiety Patents (Class 560/12)
  • Patent number: 9255222
    Abstract: The present invention provides a novel fluorescent molecule having formula 1 which exhibit emission color change when in contact with moisture useful for the preparation of fluorescent paper, allowing self-erasable writing, security label for document authenticity, check and prevention of currency counterfeit. Compound of formula 1 when coated on paper results in blue emitting surfaces on which writing is possible using water as ink. The images undergo self-erasal after 6 hours making the paper reusable or instantly with hot air. The images are visible only on illumination with a UV lamp having wavelength 365 nm. The material can be coated on any document to create security label which changes color on touching with a wet surface or water pen and will go back to the native color when the moisture is dried off after a time frame. This strategy is used to create a security label for currency bills for checking original and fake currency notes or any other documents for authenticity.
    Type: Grant
    Filed: April 20, 2015
    Date of Patent: February 9, 2016
    Assignee: Council of Scientific and Industrial Research
    Inventors: Ajayaghosh Ayyappanpillai, Thirumalai Kumaran Rajasekaran
  • Patent number: 9212154
    Abstract: Cysteine compounds represented by the following formula wherein each symbol is as defined in the specification, and salts thereof, are superior in stability, have less odor, exhibit an eumelanin production suppressive effect, and are useful as cosmetic agents.
    Type: Grant
    Filed: November 27, 2012
    Date of Patent: December 15, 2015
    Assignee: AJINOMOTO CO., INC.
    Inventors: Yusuke Amino, Yoshinobu Takino, Shinji Kuroda, Keiji Iwasaki, Megumi Kaneko, Fumie Okura
  • Publication number: 20150141641
    Abstract: The present invention provides a method for producing a 4,4,7-trifluoro-1,2,3,4-tetrahydro-5H-1-benzazepine compound which has an superior agonistic activity to an arginine vasopressin V2 receptor and is useful as an active ingredient for a pharmaceutical composition for preventing and/or treating urinary frequency, urinary incontinence, enuresis, central diabetes insipidus, nocturia, nocturnal enuresis, or the like; and useful intermediates for use in the methods. The production method of the present invention is suitable for the industrial production of a medicament, because of a smaller number of steps, a higher yield, and a lower cost, as compared with the methods in the related art.
    Type: Application
    Filed: June 11, 2013
    Publication date: May 21, 2015
    Applicant: ASTELLAS PHARMA INC.
    Inventors: Souichirou Kawazoe, Takahiro Akiba, Kiichi Sato, Akio Miyafuji, Kazuyoshi Obitsu, Junji Itoh, Shun Hirasawa, Hiroyuki Koshio
  • Patent number: 8829192
    Abstract: Described is the use of specific merocyanine derivatives for protecting body-care and household products from photolytic and oxidative degradation. These compounds perform outstanding UV absorber properties.
    Type: Grant
    Filed: July 19, 2006
    Date of Patent: September 9, 2014
    Assignee: BASF SE
    Inventors: Barbara Wagner, Oliver Reich
  • Publication number: 20140243374
    Abstract: This invention relates generally to the discovery of sulfonamide-containing compounds that are inhibitors of ?-secretase.
    Type: Application
    Filed: October 4, 2012
    Publication date: August 28, 2014
    Inventors: Corinne E. Augelli-Szafran, Dai Lu, HanXun Wei, Jing Zhang, Michael S. Wolfe, Dennis J. Selkoe, Cuiman Cai
  • Patent number: 8796485
    Abstract: By searching various kinds of compounds having CaSR agonistic activity, the present invention provides CaSR agonistic agents, pharmaceutical compositions, preventive or therapeutic agents for diarrhea and kokumi-imparting agents each of which comprise the compound. More specifically, the present invention provides CaSR agonistic agents, pharmaceutical compositions, preventive or therapeutic agents for diarrhea and kokumi-imparting agents each of which comprise a glutamic acid derivative having CaSR agonistic activity or pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: April 4, 2011
    Date of Patent: August 5, 2014
    Assignee: Ajinomoto Co., Inc.
    Inventors: Masayuki Sugiki, Toru Okamatsu, Sayaka Asari, Yayoi Kawato, Toshihiro Hatanaka, Tetsuo Yano, Yukie Seki, Naohiro Miyamura, Hiroaki Nagasaki, Yuzuru Eto, Reiko Yasuda
  • Publication number: 20140194416
    Abstract: The invention relates to N-hydroxylsulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxylsulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxylsulfonamide derivatives.
    Type: Application
    Filed: March 11, 2014
    Publication date: July 10, 2014
    Applicants: Cardioxyl Pharmaceuticals, Inc., The Johns Hopkins University
    Inventors: John P. Toscano, Frederick Arthur Brookfield, Andrew D. Cohen, Stephen Martin Courtney, Lisa Marie Frost, Vincent Jacob Kalish
  • Publication number: 20140187558
    Abstract: The invention relates to the preparation of chiral compounds, in particular to the preparation of chiral compounds which may be used as intermediates for the preparation of anti-diabetic agents, preferably sitagliptin.
    Type: Application
    Filed: May 25, 2012
    Publication date: July 3, 2014
    Applicant: LEK PHARMACEUTICALS D.D.
    Inventors: Zdenko Casar, Gaj Stavber
  • Publication number: 20140163250
    Abstract: A fluorinated bis(acyl-containing compound and a fluorinated polyester formed from the fluorinated diacyl are described. More particularly, the fluorinated diacyl has an aromatic ring bonded to two acyl groups plus at least one third group that contains a perfluoroalkylsulfonamido group. The fluorinated polyesters formed from the fluorinated diacyl-containing compound can be used to provide a low energy surface with a relatively low refractive index compared to many other polyesters.
    Type: Application
    Filed: February 11, 2014
    Publication date: June 12, 2014
    Applicant: 3M INNOVATIVE PROPERTIES COMPANY
    Inventors: Yu Yang, Lei Wang, George G.I. Moore
  • Patent number: 8686179
    Abstract: A fluorinated bis(acyl)-containing compound of Formula (I), where R1, Ar, L, R2, R3, Rf, n, p and q are as defined in the claims, and a fluorinated polyester formed from the fluorinated bis(acyl) compound are described. More particularly, the fluorinated bis(acyl) has an aromatic ring bonded to two acyl groups plus at least one third group that contains a perfluoroalkylsulfonamido group. The fluorinated polyesters formed from the fluorinated bis(acyl)-containing compound can be used to provide a low energy surface with a relatively low refractive index compared to many other polyesters. A method of preparing a monosubstituted-arylene compound of formula Rf1-L2-CH2—Ar2—CH2—W, where Ar2, Rf1, L2, R6 and W are as defined in the claims by reaction of a compound of formula Rf1-L2-H with a compound of formula W—CH2—Ar2—CH2—W.
    Type: Grant
    Filed: June 7, 2010
    Date of Patent: April 1, 2014
    Assignee: 3M Innovative Properties Company
    Inventors: Yu Yang, Lei Wang, George G. I. Moore
  • Patent number: 8680319
    Abstract: A method for producing antifolate agents having glutamic acid part in their structure is developed by protecting carboxyl groups of glutamic acid or its N-substituted derivatives as cyanomethyl ester to give compounds of formula (II) which are hydrolyzed under very mild conditions to afford antifolate agents in high yield with high analytical and optical purity.
    Type: Grant
    Filed: December 3, 2010
    Date of Patent: March 25, 2014
    Assignee: Kocak Farma Ilac ve Kimya San. A.S
    Inventors: Ender Kocak, Tuncer Aslan
  • Publication number: 20140018553
    Abstract: The invention relates to a process for synthesizing benzofuran derivatives, in particular dronedarone of formula (D), comprising a step of Friedel-Crafts acylation starting from a sulfonamido-benzofuran ester intermediate.
    Type: Application
    Filed: March 23, 2012
    Publication date: January 16, 2014
    Applicant: SANOFI
    Inventors: Bernard Grimaud, Pierre-Jean Grossi
  • Publication number: 20140011682
    Abstract: The invention relates to the use of open-chain aryl-, heteroaryl- and benzylsulfonamidocarboxylic acids, -carboxylic esters, -carboxamides and -carbonitriles or salts thereof of the formula (I) in which the respective substituents have the meanings given in the description, for increasing stress tolerance in plants with respect to abiotic stress, and also for increasing plant growth and/or for increasing plant yield.
    Type: Application
    Filed: December 27, 2011
    Publication date: January 9, 2014
    Applicant: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Jens Frackenpohl, Lothar Willms, Thomas Mueller, Stefan Lehr, Pascal Von Koskull-Doering, Ines Heinemann, Christopher Hugh Rosinger, Isolde Haeuser-Hahn, Martin Jeffrey Hills
  • Patent number: 8609881
    Abstract: The present invention provides compound(s) selected from the group of compounds represented by structural Formula (I): wherein X, Y and R1 are as described herein, use of such compounds as anaerobic cure accelerators, and compostions including such compounds.
    Type: Grant
    Filed: May 7, 2008
    Date of Patent: December 17, 2013
    Assignee: Henkel IP US LCC
    Inventors: Andrew Messana, Anthony F. Jacobine, Steven Thomas Nakos, David M. Glaser
  • Publication number: 20130237702
    Abstract: A composition containing a compound represented by General Formula (I) below (see the definition in the specification for the symbols in the formula) or a salt thereof has an excellent CaSR agonistic effect and provides a pharmaceutical agent, a CaSR agonistic agent, a prophylactic or therapeutic agent for a disease that can be ameliorated through CaSR activation as well as seasonings and an agent for imparting kokumi.
    Type: Application
    Filed: August 31, 2012
    Publication date: September 12, 2013
    Applicant: AJINOMOTO CO., INC.
    Inventors: Masayuki SUGIKI, Toru OKAMATSU, Tetsuo YANO, Shinya TANIGUCHI
  • Publication number: 20130190338
    Abstract: The present invention relates to novel sulfur derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.
    Type: Application
    Filed: March 11, 2013
    Publication date: July 25, 2013
    Applicant: ALLERGAN, INC.
    Inventor: ALLERGAN, INC.
  • Publication number: 20130109879
    Abstract: A process for converting naturally occurring fats and oils to sulfonated surfactants that can be used in a variety of applications where surfactants are found to be applicable including but not restricted to Enhanced Oil Recovery, paper and pulp processing, mining, metal treating, adhesives, coatings, pesticide formulations, herbicide formulations, fungicide formulations. The byproduct of such a process is a useful solvent or source of biodiesel fuel.
    Type: Application
    Filed: June 26, 2012
    Publication date: May 2, 2013
    Applicant: OIL CHEM TECHNOLOGIES, INC.
    Inventors: Paul D. Berger, Christie H. Berger
  • Publication number: 20130102570
    Abstract: A medicament having an excellent CaSR agonist action which enables the prevention or treatment of diabetes or obesity is provided by a composition comprising the compound represented by general formula (I) as defined, or a salt thereof.
    Type: Application
    Filed: September 28, 2012
    Publication date: April 25, 2013
    Applicant: AJINOMOTO CO., INC.
    Inventor: AJINOMOTO CO., INC
  • Publication number: 20130096319
    Abstract: The present invention is related to a novel process for the preparation of amisulpride (I) which involves: methylation of 4-amino-salicylic-acid (VI) with dimethyl sulphate and base, optionally in presence of TBAB to obtain 4-amino-2-methoxy methyl benzoate (VII) and (ii) oxidation of 4-amino-2-methoxy-5-ethyl thio benzoic acid (IX) or 4-amino-2-methoxy-5-ethyl thio methyl benzoate (X) with oxidizing agent in the presence of sodium tungstate or ammonium molybdate to give 2-methoxy-4-amino-5-ethyl-sulfonyl benzoic acid (IV) or 2-methoxy-4-amino-5-ethyl-sulfonyl methyl benzoate (XI) respectively.
    Type: Application
    Filed: June 9, 2011
    Publication date: April 18, 2013
    Applicant: Lupin Limited
    Inventors: Dinesh Jayntibhai Paghdar, Mahesh Ramkumar Kolekar, Tushar Nandkumar Deshpande, Suryaprakash Pandurang Patil, Yuvraj Atmaram Chavan, Purna Chandra Ray, Girij Pal Singh
  • Publication number: 20130059998
    Abstract: Amino acid-based poly(ester amide) (PEA) macromers (e.g., functional PEA macromers) and methods for preparing amino acid-based poly(ester amide) (PEA) macromers. The functional PEA macromers can comprise functional groups such as hydroxyl, amine, sulfonic acids, carboxyl, thiol and acryloyl at the two terminuses of the PEA macromers. The content of the terminal functional groups on the macromers can be precisely controlled by adjusting the molar ratio of reactive monomers. The resulting versatility of these new functional PEA macromers can be used to fabricate a wide range of PEAs and PEA hybrid derivatives with very different chemical, physical, mechanical, thermal and biological properties. The functional PEA macromers can also be polycondensed into forming block PEA polymers.
    Type: Application
    Filed: March 9, 2011
    Publication date: March 7, 2013
    Inventors: Chih-Chang Chu, Mingxiao Deng
  • Publication number: 20120282180
    Abstract: The present invention relates to the field of therapeutic and diagnostic agents and more specifically to compounds of formula (I) that are inhibitors of matrix-metalloproteinases (MMPs) and are useful in the treatment of diseases related thereto such as cardiovascular diseases, inflammatory diseases and malignant diseases. One embodiment of the invention is a compound of formula (I) labeled with a 18-fluorine atom having matrix metalloproteinase inhibitory activity suitable for diagnostic imaging. Also disclosed in the present invention is a pharmaceutical composition comprising the inhibitors of matrix-metalloproteinases (MMPs) of the invention or the corresponding labeled compounds useful as diagnostic imaging agents of the invention in a form suitable for mammalian administration.
    Type: Application
    Filed: June 8, 2011
    Publication date: November 8, 2012
    Inventors: Hartmuth C. Kolb, Guenter Haufe, Malte Behrends, Klaus Kopka, Stefan Wagner, Verena Hugenberg, Hans-Joerg Breyholz, Sven Hermann, Michael Schaefers
  • Publication number: 20120264605
    Abstract: Disclosed are ionic liquids and methods of preparing ionic liquid compositions of active pharmaceutical, biological, nutritional, and energetic ingredients. Also disclosed are methods of using the compositions described herein to overcome polymorphism, overcome solubility and delivery problems, to control release rates, add functionality, enhance efficacy (synergy), and improve ease of use and manufacture.
    Type: Application
    Filed: June 7, 2012
    Publication date: October 18, 2012
    Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA
    Inventors: Robin D. Rogers, Daniel T. Daly, Richard P. Swatloski, Whitney L. Hough-Troutman, James Hilliard Davis, JR., Marcin Smiglak, Juliusz Pernak, Scott K. Spear
  • Publication number: 20120264603
    Abstract: The invention encompasses formulations for increased attachment and retention systems of biologically active organic compounds and methods for the preparation and use thereof.
    Type: Application
    Filed: October 7, 2011
    Publication date: October 18, 2012
    Inventors: David S. Soane, Gangadhar Jogikalmath
  • Publication number: 20120141938
    Abstract: A chemically amplified resist composition comprising a base polymer, an acid generator, and an amine quencher in the form of a ?-alanine, ?-aminobutyric acid or 5-aminovaleric acid derivative having an acid labile group-substituted carboxyl group has a high contrast of alkaline dissolution rate before and after exposure and forms a pattern of good profile at a high resolution, minimal roughness and wide focus margin.
    Type: Application
    Filed: December 5, 2011
    Publication date: June 7, 2012
    Applicant: SHIN-ETSU CHEMICAL CO., LTD.
    Inventors: Jun Hatakeyama, Masayoshi Sagehashi, Takeru Watanabe
  • Publication number: 20120136164
    Abstract: The invention relates to a nanoparticulate material comprising long ultrathin metal nanowires, and to processes for making it. The nanoparticulate material may be used as a catalyst and, in the presence of a chiral modifier, can catalyse enantioselective reactions.
    Type: Application
    Filed: March 30, 2010
    Publication date: May 31, 2012
    Applicant: Agency for Science, Technology and Research
    Inventors: Jackie Y. Ying, Nandanan Erathodiyil, Hongwei Gu, Huilin Shao, Jiang Jiang
  • Publication number: 20120071626
    Abstract: A fluorinated bis(acyl)-containing compound of Formula (I), where R1, Ar, L, R2, R3, Rf, n, p and q are as defined in the claims, and a fluorinated polyester formed from the fluorinated bis(acyl) compound are described. More particularly, the fluorinated bis(acyl) has an aromatic ring bonded to two acyl groups plus at least one third group that contains a perfluoroalkylsulfonamido group. The fluorinated polyesters formed from the fluorinated bis(acyl)-containing compound can be used to provide a low energy surface with a relatively low refractive index compared to many other polyesters. A method of preparing a monosubstituted-arylene compound of formula Rf1-L2-CH2-Ar2—CH2—W, where Ar2, Rf1, L2, R6 and W are as defined in the claims by reaction of a compound of formula Rf1-L2-H with a compound of formula W—CH2-Ar2—CH2—W.
    Type: Application
    Filed: June 7, 2010
    Publication date: March 22, 2012
    Inventors: Yu Yang, Lei Wang, George G.I. Moore
  • Publication number: 20110301200
    Abstract: The present invention relates to novel compounds of general formula (I) which are thyroid receptor ligands and are preferably selective for the thyroid hormone receptor beta (TR-Beta). Further, the present invention relates to processes of preparing such compounds, their tautomeric forms, novel intermediates involved in their synthesis, their pharmaceutically acceptable salts, methods for using such compounds and pharmaceutical compositions containing them.
    Type: Application
    Filed: October 22, 2009
    Publication date: December 8, 2011
    Applicant: CADILA HEALTHCARE LIMITED
    Inventors: Saurin Raval, Preeti Raval
  • Patent number: 8071807
    Abstract: Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions that include the compounds described herein, and methods of using such antagonists of PGD2 receptors, alone or in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
    Type: Grant
    Filed: July 2, 2009
    Date of Patent: December 6, 2011
    Assignee: Panmira Pharmaceuticals, LLC
    Inventors: John Howard Hutchinson, Thomas Jon Seiders, Bowei Wang, Jeannie M. Arruda, Brian Andrew Stearns
  • Publication number: 20110257183
    Abstract: Compounds are provided that act as potent antagonists of chemokine receptors. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of chemokine receptor-mediated diseases, and as controls in assays for the identification of chemokine antagonists.
    Type: Application
    Filed: April 22, 2011
    Publication date: October 20, 2011
    Inventors: Solomon Ungashe, Zheng Wei, J.J. Wright, Andrew Pennell, Brett Premack, Thomas Schall
  • Publication number: 20110251418
    Abstract: By searching various kinds of compounds having CaSR agonistic activity, the present invention provides CaSR agonistic agents, pharmaceutical compositions, preventive or therapeutic agents for diarrhea and kokumi-imparting agents each of which comprise the compound. More specifically, the present invention provides CaSR agonistic agents, pharmaceutical compositions, preventive or therapeutic agents for diarrhea and kokumi-imparting agents each of which comprise a glutamic acid derivative having CaSR agonistic activity or pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: April 4, 2011
    Publication date: October 13, 2011
    Applicant: AJINOMOTO CO., INC.
    Inventors: Masayuki Sugiki, Toru Okamatsu, Sayaka Asari, Yayoi Kawato, Toshihiro Hatanaka, Tetsuo Yano, Yukie Seki, Naohiro Miyamura, Hiroaki Nagasaki, Yuzuru Eto, Reiko Yasuda
  • Publication number: 20110230641
    Abstract: Embodiments of this disclosure, among others, encompass methods for generating alkenes under mild thermolytic conditions that can provide almost total conversion of a precursor compound to an alkene without isomerization or the need to chromatographically purify the final product By selectively blocking the amino and carboxy groups of the de?vatized amino acid, the methods of the disclosure provide for the synthesis of a peptide having the vinylglycine moiety at either the carboxy or the amino terminus of the peptide The mild conditions for the thermolytic removal of an o-NO2-phenyl substituted aryl group ensure that there is minimal if any damage to thermally sensitive conjugates such as a peptide bearing the vinylglycine The methods of the present disclosure have practical applications for the preparation of unsaturated compounds under mild, thermolytic conditions.
    Type: Application
    Filed: November 17, 2009
    Publication date: September 22, 2011
    Inventors: Timothy Edward Long, Sravan Kumar Patel
  • Publication number: 20110212918
    Abstract: This invention relates to, among other items, 6-substituted benzoxaborole compounds and their use for treating bacterial infections.
    Type: Application
    Filed: November 11, 2010
    Publication date: September 1, 2011
    Applicant: Anacor Pharmaceuticals, Inc.
    Inventors: Vincent S. Hernandez, Xianfeng Li, Suoming Zhang, Tsutomu Akama, Yanchen Zhang, Yang Liu, Jacob J. Plattner, Michael Richard Kevin Alley, Yasheen Zhou, James A. Nieman
  • Patent number: 8003083
    Abstract: The present invention is benzilidene malonamide represented by the following formula (1) and salts thereof, an ultraviolet absorbent consisting of said new compound, and an external preparation containing this ultraviolet absorbent. The object of the present invention is to provide a new ultraviolet absorbent that is highly soluble in water, has superior absorption capacity over a wide ultraviolet wavelength range, has no absorption in the visible region, and is also highly stable and safe.
    Type: Grant
    Filed: June 11, 2007
    Date of Patent: August 23, 2011
    Assignee: Shiseido Company, Ltd.
    Inventors: Takuya Hiruma, Masaru Suetsugu
  • Publication number: 20110190302
    Abstract: The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl-phenyl-sulfonamido-phenylene compounds of the following formula (I) (collectively referred to herein as “APSAP compounds”).
    Type: Application
    Filed: September 18, 2009
    Publication date: August 4, 2011
    Applicant: PIMCO 2664 LIMITED
    Inventors: Iain Robert Greig, Rose Mary Sheridan, Raymond Fisher, Matthew John Tozer, Juha Andrew Clase, Andrew Smith, Andrew Robert Tuffnell, Robert Jurgen Van 't Hof
  • Publication number: 20110184034
    Abstract: The present invention provides an agent for the prophylaxis or treatment of severe sepsis, which contains a compound represented by the formula (I): or, the formula (II): or a salt thereof or a prodrug thereof, a TLR signal inhibitor containing a non-peptide compound and an agent for the prophylaxis or treatment of organ dysfunction and the like, which contains a TLR signal inhibitory substance.
    Type: Application
    Filed: March 30, 2011
    Publication date: July 28, 2011
    Inventors: Masayuki Ii, Yuji Iizawa, Tomoyuki Kitazaki, Kazuki Kubo
  • Publication number: 20110172189
    Abstract: The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl-phenyl-sulfonamido-cycloalkyl compounds of the following formula (collectively referred to herein as “APSAC compounds”).
    Type: Application
    Filed: September 18, 2009
    Publication date: July 14, 2011
    Applicant: PIMCO 2664 LIMITED
    Inventors: Iain Robert Greig, Rose Mary Sheridan, Raymond Fisher, Matthew John Tozer, Juha Andrew Clase, Andrew Smith, Andrew Robert Tuffnell, Robert Jurgen Van 't Hof
  • Patent number: 7968597
    Abstract: (2R)-2-Phenylcarbonyloxypropyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate mesylate and crystalline form thereof, methods of making the same, pharmaceutical compositions thereof, and methods of using the same to treat diseases or disorders such as Parkinson's disease are provided.
    Type: Grant
    Filed: December 31, 2008
    Date of Patent: June 28, 2011
    Assignee: XenoPort, Inc.
    Inventors: Jia-Ning Xiang, Xuedong Dai, Cindy X. Zhou, Jianhua Li, Mark Q. Nguyen
  • Publication number: 20110136827
    Abstract: The invention provides certain bis-acylated hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the invention provides methods of using such compounds or pharmaceutical compositions for treating, preventing, or delaying the onset and/or develop of a disease or condition. In some embodiments, the disease or condition is selected from cardiovascular diseases, ischemia, reperfusion injury, cancerous disease, pulmonary hypertension and conditions responsive to nitroxyl therapy.
    Type: Application
    Filed: December 7, 2010
    Publication date: June 9, 2011
    Inventors: John P. Toscano, Art Sutton, Vincent J. Kalish, Frederick Arthur Brookfield, Stephen Martin Courtney, Lisa Marie Frost
  • Publication number: 20110105544
    Abstract: The invention provides novel compounds of formula (I), wherein: R1 is a radical derived from one of the known ring systems; R2 is a phenyl radical optionally substituted; Xn represents a birradical selected from the group consisting of: —(CH2)1-4—, (C2-C4)-alkenyl, (C2-C4)alkynyl, —S—(CH2)1-3—#, and —(CH2)1-3—O—#; wherein the symbol # indicates the position at which Xn is attached to R1; Yn is a birradical selected from the group consisting of: —(CH2)2-4—, —S—(CH2)1-3#, and —O—(CH2)1-3—#; wherein the symbol # indicates the position at which Yn is attached to R2; and R3 is a radical selected from the group consisting of: —OR4. The compounds of formula (I) are useful in the treatment of cancer.
    Type: Application
    Filed: December 18, 2008
    Publication date: May 5, 2011
    Inventors: Juan Aymami Bofarull, Franck Camille Nicolas Chevalier, Montserrat Soler Lopez, Maria Teresa Luque Garrofe, Marc Martinell Pedemonte
  • Patent number: 7932326
    Abstract: Novel di- and tripodal compounds useful as chelators, intermediates for their production and a method for treating an aqueous solution to remove trivalent metal ions are presented.
    Type: Grant
    Filed: April 16, 2008
    Date of Patent: April 26, 2011
    Assignee: The University of Kentucky Research Foundation
    Inventors: Robert A. Yokel, Wesley R. Harris, Christopher D. Spilling, Chang-Guo Zhan
  • Patent number: 7931946
    Abstract: Disclosed are a novel liquid crystal compound containing a sulfone group, a liquid crystal composition comprising the same, and an optical film using the same liquid crystal composition. More particularly, there are provided a liquid crystal material for a viewing angle compensation film with high quality characteristics, which can improve a contrast ratio measured at a tilt angle to the front and minimize variations in color with viewing angles in a black state, a liquid crystal composition comprising the same liquid crystal material, and a compensation film obtained from the same liquid crystal composition.
    Type: Grant
    Filed: January 22, 2008
    Date of Patent: April 26, 2011
    Assignee: LG Chem, Ltd.
    Inventors: Jae-Ho Cheong, Min-Jin Ko, Myung-Sun Moon, Bum-Gyu Choi, Dae-Ho Kang, Ki-Youl Lee, Yun-Bong Kim
  • Publication number: 20110088594
    Abstract: The present invention relates to compounds of the formulae (I), (II) and (III), to the use of compounds containing at least one perfluoro-tert-butoxy group and at least one substituted or unsubstituted aromatic end group as surface-active agent, and to a process for the preparation of compounds of the formula (II).
    Type: Application
    Filed: May 15, 2009
    Publication date: April 21, 2011
    Inventors: Eckhard Claus, Fanny Schooren, Martin Seidel, Wolfgang Hierse, Peer Kirsch
  • Publication number: 20110060043
    Abstract: The present invention provides novel compounds that inhibit cell proliferation and uses of these compounds for treating, ameliorating or preventing diseases, conditions or disorders benefiting from the inhibition hyperproliferation.
    Type: Application
    Filed: March 2, 2009
    Publication date: March 10, 2011
    Applicant: European Molecular Biology Laboratory (EMBL)
    Inventors: George Reid, Maria Polycarpou-Schwarz, Frank Gannon
  • Patent number: 7893270
    Abstract: The present invention relates to a process for the preparation of compounds of formula (I), wherein the substituents are as defined in claim 1, by reacting a compound of formula (II), with a bromine or chlorine source to form a compound of formula (III), wherein X is chlorine or bromine; reacting that compound with water to form the compound of formula (IV), converting that compound, using a compound of formula (V), wherein M+ is the hydrogen cation or an alkali metal ion, alkaline earth metal ion or ammonium ion, into the compound of formula (VI), and treating that compound with a cyanide source in the presence of a base.
    Type: Grant
    Filed: April 29, 2005
    Date of Patent: February 22, 2011
    Assignee: Syngenta Crop Protection, Inc.
    Inventors: David Anthony Jackson, Andrew Edmunds, Martin Charles Bowden, Ben Brockbank
  • Patent number: 7884103
    Abstract: The invention relates to N-sulfonyl-?-amino-acetic acid derivatives of the general formula (I): including the optical isomers thereof and mixtures of such isomers, wherein Ar1 and Ar2 independently of each other stand for an optionally substituted aryl or heteroaryl group, R1 and R2 stand independently of each other for hydrogen, optionally substituted C1-C5alkyl, optionally substituted C2-C5alkenyl, C-2C5alkynyl or optionally substituted C3C6Cycloalkyl; R3 designates hydrogen, C-3C5alkenyl, C3-C5 alkynyl or optionally substituted C1-C5alkyl; R4 is optionally substituted C1-C5alkyl, optionally substituted C-2C5alkenyl, C-2C5aklynyl or optionally substituted C-3C6 cycloalkyl; R5 and R6 are independently of each other hydrogen or optionally substituted C1-C5alkyl, optionally substituted C2-C5alkenyl, C-2C5alkynyl or optionally substituted C3-C6cycloalkyl; R7 and R8 are independently of each other hydrogen or optionally substituted C1-C5alkyl, optionally substituted C2-C5alkenyl, C2-C5alkynyl or optionally subst
    Type: Grant
    Filed: August 27, 2004
    Date of Patent: February 8, 2011
    Assignee: Syngenta Crop Protection, Inc.
    Inventor: Urs Müller
  • Publication number: 20110003827
    Abstract: A compound of the formula is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
    Type: Application
    Filed: December 10, 2004
    Publication date: January 6, 2011
    Inventors: Charles A. Flentge, Hui-Ju Chen, David A. DeGoey, William J. Flosi, David J. Grampovnik, Peggy P. Huang, Dale J. Kempf, Larry L. Klein, Allan C. Krueger, Darold L. Madigan, John T. Randolph, Minghua Sun, Ming C. Yeung, Chen Zhao
  • Publication number: 20100317854
    Abstract: The invention relates to compounds of formulae (II), (IV), and (VI) as shown below, wherein the several variable groups are as defined in the specification and claims. Processes for making these materials, and methods for using them in the synthesis of compounds for treatment of cardiovascular disorders and fibrotic disorders are also disclosed.
    Type: Application
    Filed: August 23, 2010
    Publication date: December 16, 2010
    Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
    Inventors: Cristina Alonso-Alija, Markus Heil, Dietmar Flubacher, Paul Naab, Josef Pernerstorfer, Johannes-Peter Stasch, Frank Wunder, Klaus Dembowsky, Elizabeth Perzborn, Elke Stahl
  • Publication number: 20100266500
    Abstract: This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting the aggregation of amyloid proteins to form amyloid deposits, and a method of delivering a therapeutic agent to amyloid deposits.
    Type: Application
    Filed: April 22, 2010
    Publication date: October 21, 2010
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Hank F. Kung, Mei-Ping Kung, Zhi-Ping Zhuang
  • Publication number: 20100249118
    Abstract: Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
    Type: Application
    Filed: June 21, 2006
    Publication date: September 30, 2010
    Inventors: Prabha N. Ibrahim, Dean R. Artis, Ryan Bremer, Shumeye Mamo, Chao Zhang, Jiazhong Zhang, James Tsai, Klaus-Peter Hirth, Gideon Bollag, Wayne Spevak, Hanna Cho, Samuel J. Gillette, Shenghua Shi
  • Publication number: 20100210694
    Abstract: The present invention refers to new NO-donors aspirin derivatives, a process for their preparation and pharmaceutical compositions containing them.
    Type: Application
    Filed: September 3, 2008
    Publication date: August 19, 2010
    Applicant: NICOX S.A.
    Inventors: Roberta Fruttero, Alberto Gasco, Loretta Lazzarato, Monica Donnola, Barbara Rolando, Stefano Biondi