Alicyclic Acid Moiety Containing Oxy, Aldehyde Or Ketone Group Patents (Class 560/126)
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Publication number: 20110003773Abstract: Described herein are methods for treating lack of hair growth or a reduction or loss of existing hair by stimulating and/or restoring hair growth, or preventing hair loss. The methods comprise administering to a subject in need thereof a therapeutically effective amount of a fullerene.Type: ApplicationFiled: March 3, 2009Publication date: January 6, 2011Applicant: Luna Innovations IncorporatedInventors: Christopher L. Kepley, Robert P. Lenk, Stephen R. Wilson, Zhiguo Zhou
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Patent number: 7862980Abstract: The present invention provides a salt represented by the formula (I): wherein P1, P2, P3, Q1, Q2 and R are defined in the specification and the present invention further provides a chemically amplified resist composition comprising the salt represented by the above-mentioned formula (I).Type: GrantFiled: July 30, 2007Date of Patent: January 4, 2011Assignee: Sumitomo Chemical Company, LimitedInventors: Yukako Harada, Isao Yoshida, Yoshiyuki Takata
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Publication number: 20100331413Abstract: A highly pure asiaticoside and a pharmaceutical grade asiatic acid can be prepared, along with salts of asiatic acid, for use in formulating therapeutic compositions that are suitable for treating arthritis, psoriasis and other inflammatory diseases, as well as pulmonary fibrosis, diabetic nephropathy, and other fibrotic diseases.Type: ApplicationFiled: January 8, 2009Publication date: December 30, 2010Inventors: Ying Liu, Quanhai Liu, Yan Qin, Tong Wu, Zhiru Xu, Min-yu Liu, Fei Li, Yan Li, Michael J. Newman
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Publication number: 20100273801Abstract: The invention relates to compouns derived from betulin, and to the use thereof as antibacterial agents in pharmaceutical and cosmetic applications.Type: ApplicationFiled: June 6, 2007Publication date: October 28, 2010Applicant: Valition teknillinen tutikimuskeskusInventors: Jari Yli-Kauhaluoma, Salme Koskimies, Sami Alakurtti, Taru Mäkelä, Päivi Tammela
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Publication number: 20100216876Abstract: An antidiarrhetic composition is provided which is efficacious against diarrhea, in particular, the predominant secretory diarrhea; an antidiarrhetic medicinal composition containing the same is also provided; a food containing the antidiarrhetic composition is also provided; and a method of preventing diarrhea using the same is also disclosed. The composition for relieving diarrhea is a cool composition capable of acting on the digestive tract in the recipient's body and inhibiting the secretion of the intestinal Cl?. In other words, a composition containing one or more kinds of cool act compounds. It may be provided by adding to medicines, foods or drinks.Type: ApplicationFiled: October 2, 2008Publication date: August 26, 2010Inventors: Yuichi Suzuki, Kenya Ishida
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Patent number: 7692033Abstract: A process produces a 2-benzoyloxyacetaldehyde derivative represented by following Formula (3): wherein R1 and R2 may be the same as or different from each other and are each a hydrocarbon group, wherein R1 and R2 may be combined to form a ring with the adjacent oxygen-carbon-oxygen bond, and wherein the benzene ring in the formula may be substituted, by allowing a halogenated acetaldehyde acetal derivative represented by following Formula (1): wherein R1 and R2 are as defined above; and X represents a halogen atom, to react with a benzoate represented by following Formula (2): wherein M represents an alkali metal atom and wherein the benzene ring in the formula may be substituted, in the presence of an alkali-metal halide.Type: GrantFiled: March 11, 2005Date of Patent: April 6, 2010Assignee: Daicel Chemical Industries, Ltd.Inventor: Kazuyoshi Nishikawa
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Publication number: 20100076077Abstract: Esters of 4,5-disubstituted-oxy-2-methyl-3,6-dioxo-cyclohexa-1,4-dienyl alkyl acids were prepared chemically and/or enzymatically. Depending upon the ester, improved melanocyte cytotoxicity was achieved. Improved cytotoxicity characteristics are consistent with ester analogs being more physiologically compatible and less irritating to skin than their corresponding acids.Type: ApplicationFiled: September 23, 2008Publication date: March 25, 2010Applicant: Eastman Chemical CompanyInventors: Michael Fitzpatrick Wempe, Liu Deng, Stephanie Kay Clendennen, Neil Warren Boaz
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Publication number: 20100034766Abstract: A malodor counteracting composition comprising at least one compound of formula (A) and at least one compound of formula (B) wherein n, X, Y and R1 to R4 are as defined in the description.Type: ApplicationFiled: October 22, 2007Publication date: February 11, 2010Applicant: Givaudan SAInventors: Thomas McGee, Felix Flachsmann, Markus Gautschi, Philip Kraft, Richard P. Sgaramella, Kumar Venkateswara Vedantam
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Publication number: 20100022461Abstract: Disclosed is tonovel cyclic derivatives having potent inhibiting effect on melanin formation and skin hyper-pigmentation activity with no adverse response to skin. They can be used as the therapeutics for treating and preventing the skin disease caused by over-reproduced melanin.Type: ApplicationFiled: July 2, 2007Publication date: January 28, 2010Applicant: WONKISOPHARM CO., LTD.Inventors: Hyun Chul Cho, Yonghyun Choi, Jonghan Yhei
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Patent number: 7629487Abstract: Provided herein are catalysts useful in enabling and promoting the insertion of alkylene oxides into ester linkages. The esters employed as a substrate to be alkoxylated include esters of fatty acids, such as methyl esters of C14 to C22 fatty acids, and mono-, di-, and tri-esters of glycerine, including vegetable oils, animal fats, and plant oils. A catalyst according to the invention includes at least two alkaline earth compounds, which may include any known stable compounds of the alkaline earths, and optionally contains one or more additional materials such as a carboxylic acid or a polyalkylene glycol having a molecular weight between about 100 and 1500 or a C1-C10 alkyl-capped polyalkylene glycol having molecular weight between about 100 and 1500, which has been acidified with a strong mineral acid. The preferred alkaline earths employed are salts and compounds of magnesium and calcium.Type: GrantFiled: May 31, 2005Date of Patent: December 8, 2009Assignee: Huntsman Petrochemical LLCInventors: George A. Smith, James O'Neill, Lindy R. Coker, legal representative, George Sneed, Christopher J. Whewell
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Patent number: 7611822Abstract: The present invention provides a salt represented by the formula (I): wherein Q1 and Q2 each independently represent a fluorine atom or a C1-C6 perfluoroalkyl group, T represents a methylene group or a carbonyl group, R represents an adamantyl group substituted with at least one selected from the group consisting of a C1-C4 alkyl group, a C1-C4 alkoxy group, a hydroxyl group, a hydroxymethyl group, a cyano group and an oxo group, and A+ represents an organic counter ion. The present invention further provides a chemically amplified resist composition comprising the salt represented by the above-mentioned formula (I).Type: GrantFiled: July 22, 2008Date of Patent: November 3, 2009Assignee: Sumitomo Chemical Company, LimitedInventor: Ichiki Takemoto
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Patent number: 7579132Abstract: The present invention provides a salt represented by the formula (I): wherein X represents an n-valent connecting group, Y1 and Y2 each independently represent a fluorine atom or a C1-C6 perfluoroalkyl group, n represents 2 or 3, and A+ represents an organic counter ion. The present invention further provides a chemically amplified resist composition comprising the salt represented by the above-mentioned formula (I).Type: GrantFiled: June 4, 2007Date of Patent: August 25, 2009Assignee: Sumitomo Chemical Company, LimitedInventors: Yukako Harada, Isao Yoshida, Satoshi Yamaguchi
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Publication number: 20090181878Abstract: The present invention relates to the field of perfumery. More particularly, it concerns compounds comprising at least one ?-oxy or ?-thio carbonyl moiety capable of liberating a perfuming molecule such as, for example, an ?,?-unsaturated ketone, aldehyde or carboxylic ester. The present invention concerns also the use of the compounds in perfumery as well as the perfuming compositions or perfumed articles comprising the invention's compounds.Type: ApplicationFiled: February 25, 2009Publication date: July 16, 2009Inventors: Charles Fehr, Arnaud Struillou, Jose Galindo
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Publication number: 20090128769Abstract: A compound of the following formula (1): CH2?CR1—COO—R2—OCO-Cy-COO-Cy-A-Cy-R3??(1) wherein R1 is a hydrogen atom or a methyl group; R2 is a hydrocarbon group having from 1 to 8 carbon atoms, provided that some or all of hydrogen atoms bonded to carbon atoms in the group may be substituted by fluorine atoms, and when it has 2 or more carbon atoms, it may have an etheric oxygen atom in a carbon-carbon bond, R3 is an alkyl or alkoxy group having from 1 to 8 carbon atoms, or a fluorine atom, provided that when it is the alkyl or alkoxy group, some or all of hydrogen atoms bonded to carbon atoms in the group may be substituted by fluorine atoms; Cy is a trans-1,4-cyclohexylene group, provided that hydrogen atoms bonded to carbon atoms in the group may independently be substituted by fluorine atoms, chlorine atoms or methyl groups; and A is a single bond, a trans-1,4-cyclohexylene group or a 1,4-phenylene group, provided that hydrogen atoms bonded to carbon atoms in the group may independently be substituted byType: ApplicationFiled: November 12, 2008Publication date: May 21, 2009Applicant: Asahi Glass Company, LimitedInventors: Kenichi Shioya, Makoto Hasegawa, Hiroshi Kumai
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Patent number: 7534915Abstract: The present invention relates to a novel trisubstituted cyclic thickener or gelator. The present invention further relates to a method for thickening or gelating a solution comprising the use of such a gelator or thickener. A gelator or thickener according to the invention may, for instance, be used for pharmaceutical or cosmetic purposes. It may further be used as a support material in chromatographic materials or catalytically active materials.Type: GrantFiled: May 11, 2006Date of Patent: May 19, 2009Assignee: Applied Nanosystems B.V.Inventors: Kjeld Jacobus Cornelis van Bommel, Johannes Henricus van Esch
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Publication number: 20090093638Abstract: The present invention relates to compositions and methods for achieving the efficient allylic oxidation of organic molecules, especially olefins and steroids, under aqueous conditions. The invention concerns the use of dirhodium (II,II) “paddlewheel complexes, and in particular, dirhodium carboximate and tert-butyl hydroperoxide as catalysts for the reaction. The use of aqueous conditions is particularly advantageous in the allylic oxidation of 7-keto steroids, which could not be effectively oxidized using anhydrous methods, and in extending allylic oxidation to enamides and enol ethers.Type: ApplicationFiled: October 6, 2008Publication date: April 9, 2009Applicant: UNIVERSITY OF MARYLAND, COLLEGE PARKInventors: Michael P. Doyle, Arthur J. Catino, Hojae Choi, Jason M. Nichols
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COMPOUNDS HAVING ISOCYANATE FUNCTIONAL GROUP SUBSTITUENTS AND COATING COMPOSITIONS COMPRISED THEREOF
Publication number: 20090076240Abstract: Novel compounds having an average isocyanate functionality of greater than 2 are synthesized by the reaction of a (poly)isocyanate having an average functionality of greater than 2, with a compound X comprising a function B(H)n or B?(H)n? where n is equal to 1 or 2, n? is equal to 1, 2 or 3, H is a labile hydrogen atom and B is O, S, N, N being a primary or secondary nitrogen atom, —C(?O)—O, —C(?O)—N, or else the groups O?P(O)2; O?P(O)OR1; O?P(O)3; O?P(O)2OR1; O—P(O)—OR1, and B? is —SiR2R3R4, such reaction being carried out with a compound X/[compound X+(poly)isocyanate] weight ratio of at most 50%; compositions comprised thereof are of the hardener type and can be formulated into coatings of the paint or varnish type.Type: ApplicationFiled: November 28, 2006Publication date: March 19, 2009Applicant: Rhodia OperationsInventors: Jean-Marie Bernard, Philippe Barbeau, Philippe Olier -
Patent number: 7488844Abstract: The present invention provides a compound of formula I processes for preparing such compounds, their the utility in treating clinical conditions including lipid disorders (dyslipidemias) whether or not associated with insulin resistance, methods for their therapeutic use and pharmaceutical compositions containing them.Type: GrantFiled: December 30, 2004Date of Patent: February 10, 2009Assignee: AstraZeneca ABInventors: Eva-Lotte Lindstedt Alstermark, Anna Christina Olsson, Lanna Li
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Publication number: 20090035699Abstract: Fluorinated monomers of formula (1) are useful in producing polymers for the formulation of radiation-sensitive resist compositions. R1 is H or monovalent C1-C20 hydrocarbon group, R2 is H, F, methyl or trifluoromethyl, R3 and R4 are H or a monovalent C1-C8 hydrocarbon group, or R3 and R4 may form an aliphatic hydrocarbon ring, and A is a divalent C1-C6 hydrocarbon group.Type: ApplicationFiled: June 25, 2008Publication date: February 5, 2009Inventors: Koji HASEGAWA, Takeshi KINSHO, Katsuhiro KOBAYASHI, Tsunehiro NISHI, Takeru WATANABE
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Publication number: 20080311507Abstract: Disclosed is a fluorine-containing compound represented by formula (1), wherein R1 represents a polymerizable double-bond containing group, R2 represents an acid-labile protecting group, R3 represents a fluorine atom or fluorine-containing alkyl group, and W represents a bivalent linking group. This compound can provide a fluorine-containing polymer compound that has a weight-average molecular weight of 1,000-1,000,000 and contains a repeating unit represented by formula (2), wherein R2, R3 and W are defined as above, each of R4, R5 and R6 independently represents a hydrogen atom, fluorine atom or monovalent organic group, at least two of R4, R5 and R6 may be combined to form a ring. This polymer compound can provide a resist composition capable of forming a pattern that is transparent to exposure light and superior in rectangularity.Type: ApplicationFiled: June 11, 2008Publication date: December 18, 2008Applicant: Central Glass Company, LimitedInventors: Yoshimi ISONO, Jonathan Joachim JODRY, Satoru NARIZUKA
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Patent number: 7419761Abstract: A photoresist polymer having a spiro cyclic ketal group, and a photoresist composition including the same is disclosed. The photoresist polymer and the photoresist composition can improve the resolution and the process margin due to its low activation energy of the deprotection reaction of the spiro cyclic ketal group, and can produce fine photoresist patterns due to its low PEB (Post Exposure Baking) temperature sensitivity.Type: GrantFiled: September 15, 2005Date of Patent: September 2, 2008Assignee: Dongjin Semichem Co., Ltd.Inventors: Jae-Woo Lee, Jung-Youl Lee, Deog-Bae Kim, Jae-Hyun Kim, Eun-Kyung Son
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Publication number: 20080200339Abstract: Bicyclic abscisic acid (ABA) analogs of Formula (I) and (II) and the process for their production are disclosed. The bicyclic ABA analogs include the structural elements and functional groups of the parent molecule that are required for activity, and have an aromatic ring fused to the ring replacing the vinyl methyl group of absicisie acid. Methods for using the bicyclic ABA analogs to inhibit cell growth and seed germination are also disclosed.Type: ApplicationFiled: May 10, 2005Publication date: August 21, 2008Applicant: NATIONAL RESEARCH COUNCIL OF CANADAInventors: Suzanne Abrams, Adrian J. Cutler, Patricia Rose, James Nyangulu, Ken M. Nelson
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Publication number: 20080193432Abstract: The present invention provides compounds having estrogenic activity selected from the group consisting of RRR-?-tocopherol, hydro-Q9 chromene, coenzyme Q9, cycloartane, 1-Feruloyl glycerol, ?-tocopherol-9, and analogues thereof. The compounds of the present invention activate ER? and ER?, and express high estrogenic activity.Type: ApplicationFiled: February 9, 2007Publication date: August 14, 2008Applicant: NATIONAL TAIWAN UNIVERSITYInventors: Ching-jang Huang, Wei-Yi Cheng, Yueh-Hsiung Kuo, Yi-Ming Chiang
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Patent number: 7375135Abstract: The invention concerns novel molecules, their preparation and their uses, in particular in the field of human and veterinary medicine and cosmetics. The inventive compounds are partly fatty acid derivatives and exhibit advantageous pharmacological and cosmetic properties. The invention also concerns various uses of said compounds, the pharmaceutical compositions containing them and methods for preparing them. The inventive compounds are useful in particular for preventing and/or treating dyslipidemiae, cardiovascular diseases, syndrome X, restenosis, diabetes, obesity, hypertension, certain cancers, dermatological diseases and in cosmetics, for fighting against skin aging and its effects notably against wrinkles and the like.Type: GrantFiled: August 8, 2002Date of Patent: May 20, 2008Assignee: GenfitInventors: Jamila Najib-Fruchart, Karine Caumont-Bertrand
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Patent number: 7371889Abstract: The invention relates to new chemical compounds that inhibit the various enzymes in the arachidonic acid pathway implicated in inflammatory disease conditions.Type: GrantFiled: March 11, 2007Date of Patent: May 13, 2008Assignee: Sami Labs LimitedInventors: Muhammed Majeed, Kalyanam Nagebhuananam, Rajendran Ramanujam, Subbalakshmi Prakash
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Patent number: 7371505Abstract: A positive working photosensitive composition which is useful in the manufacturing step of a semiconductor such as IC, the manufacture of a circuit board such as liquid crystals and thermal heads, and other fabrication steps and has an excellent resolution and line edge roughness, and a method for forming a pattern using the same, are provided, which are a photosensitive composition containing (A) a resin having a repeating unit having a specific group, whose solubility in an alkaline developer increases by the action of an acid, and a method for forming a pattern using the same.Type: GrantFiled: June 28, 2005Date of Patent: May 13, 2008Assignee: FUJIFILM CorporationInventor: Kunihiko Kodama
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Patent number: 7361664Abstract: A compound of formula: wherein X is a C2-10 spacer, and R is a substituted or unsubstituted C6-30 aryl, a substituted or unsubstituted C5-30 heteroaryl, or Where R? and R? are independently a substituted or unsubstituted aryl or a substituted or unsubstituted alkyl, wherein said compound is a vitamin D receptor (VDR) antagonist, a compound comprising same, and a method of treating a patient for a disease that can be treated prophylactically or therapeutically by administration of a VDR antagonist, which method comprises administering an effective amount of aforementioned compound or composition, whereupon the patient is treated prophylactically or therapeutically for the disease.Type: GrantFiled: June 20, 2002Date of Patent: April 22, 2008Assignee: The United States of America as represented by the Department of Health and Human ServicesInventor: Julianna Barsony
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Patent number: 7358276Abstract: The invention concerns 2-oxo-1-pyrrolidine derivatives of formula I, wherein the substituents are as defined in the specification, as well as their use as pharmaceuticals. The compounds of the invention are particularly suited for treating neurological disorders such as epilepsy.Type: GrantFiled: January 27, 2005Date of Patent: April 15, 2008Assignee: UCB, S.A.Inventors: Edmond Differding, Benoît Kenda, Bénédicte Lallemand, Alain Matagne, Philippe Michel, Patrick Pasau, Patrice Talaga
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Patent number: 7351851Abstract: A method for the production of 6,6,6-trihalo-3,5-dioxohexanoic acid esters of formula (I): in addition to the enols thereof and <I>E</I> and <I>Z</I> isomers, wherein X independently represents fluorine, chlorine or bromine and R1 represents alkyl, cycloalkyl, aryl or aralkyl. A method for the production of enol ethers of formula (Ib): and the enols thereof (E and Z isomers) wherein X and R1 have the above-mentioned meanings.Type: GrantFiled: October 22, 2004Date of Patent: April 1, 2008Assignee: Lonza AGInventors: Paul Hanselmann, Wolfgang Wenger
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Patent number: 7348450Abstract: A method for the production of 6,6,6-trihalo-3,5-dioxhexanoic acid esters of formula (I): in addition to the enols thereof and <I>E</I> and <I>Z</I> isomers, wherein X independently represents fluorine, chlorine or bromine and R1 represents alkyl, cycloalkyl, aryl or aralkyl. A method for the production of enol ethers of formula (Ib): and the enols thereof (E and Z isomers) wherein X and R1 have the above-mentioned meanings.Type: GrantFiled: May 3, 2006Date of Patent: March 25, 2008Assignee: Lonza Ltd.Inventors: Paul Hanselmann, Wolfgang Wenger
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Patent number: 7301046Abstract: The present invention relates to optically active boronate derivatives which are useful as intermediates for the synthesis of HMG-CoA enzyme inhibitors such as atorvastatin, cerivastatin rosuvastatin, pitavastatin, and fluvastatin.Type: GrantFiled: February 25, 2002Date of Patent: November 27, 2007Assignee: Biocon LimitedInventors: Tom Thomas Puthiaparampil, Sumithra Srinath, Madhavan Sridharan, Sambasivam Ganesh
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Publication number: 20070208079Abstract: The present invention relates to the use of certain novel myriceric acid derivatives of the formula: which are inhibitors of nuclear factor kappa B (NF-?B) and inhibit the activity of the endothelin receptor for use in the treatment of cardiovascular and inflammatory diseases and for cancers susceptible to an NF-?B inhibitor and an endothelin receptor inhibitor. The present invention also relates to compounds and methods useful to inhibit cell proliferation and for the induction of apoptosis.Type: ApplicationFiled: March 1, 2007Publication date: September 6, 2007Applicant: SaviPu PharmaceuticalsInventors: Inderjit Kumar Dev, Ven Subbiah
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Patent number: 7199239Abstract: A compound of formula (I) or a pharmaceutically acceptable salt, solvate, or hydrolysable ester thereof, Wherein: R1 and R2 are independently hydrogen or C1-3 alkyl; X represents a bond, CH2 or O; R3 and R4 are independently hydrogen, C1-6 alkyl, OCH3, CF3, allyl or halogen; X1 is CH2, SO2, or CO; R5 is —C1-6 alkyl (optionally substituted by C1-6alkoxy or C1-6alkylthio), —C2-6 alkenyl, —C0-6 alkyl phenyl (wherein the phenyl is optionally substituted by one or more CF3, halogen, C1-3 alkyl, C1-3 alkoxy), —COC1-6 alkyl, SO2C1-6 alkyl; R6 is phenyl or a 6 membered heteroaryl group containing 1, 2 or 3 N atoms wherein the phenyl or heteroaryl group is optionally substituted with 1, 2 or 3 moieties selected from the group consisting of C1-6 alkyl, halogen, —OC1-6 alkyl, —SO2C1-3 alkyl, phenyl (optionally substituted by one or more groups selected from halogen, CF3, C1-3 alkyl, OC1-3 alkyl, acetyl, CN).Type: GrantFiled: June 18, 2003Date of Patent: April 3, 2007Assignee: SmithKline Beecham CorporationInventors: Paul John Beswick, John David Harling, Savvas Kleanthous, Millard Hurst Lambert, III, Vipulkumar Kantibhai Patel, Juliet Simpson
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Patent number: 7196051Abstract: The invention relates to a process for the preparation of cyclohexyloxyacetic alkyl esters by hydrogenation of phenoxyacetic alkyl esters and to the use of cyclohexyloxyacetic alkyl esters as fragrances.Type: GrantFiled: December 3, 2002Date of Patent: March 27, 2007Assignee: Symrise GmbH & Co. KGInventors: Walter Kuhn, Hans-Ulrich Funk, Gerhard Senft
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Patent number: 7189688Abstract: The present invention concerns a compound or mixtures of compounds of formula wherein R represents a linear, branched or cyclic C1-3 hydrocarbon group, and the wavy line indicates that the substituents on the epoxide moiety may have a cis or trans configuration. One or more of these compounds can be used as perfuming ingredients.Type: GrantFiled: February 17, 2004Date of Patent: March 13, 2007Assignee: Firmenich SAInventors: Alvin Scott Williams, Charles Fehr
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Patent number: 7157595Abstract: According to one embodiment the invention concerns a process for a degradation of an epothilone C or a epothilone D, wherein an epothilone C or epothilone D is subjected to an olefin metathesis in the presence of ethylene and subsequently an optional ester hydrolysis.Type: GrantFiled: February 27, 2002Date of Patent: January 2, 2007Assignee: Helmholtz-Zentrum fur Infektionsforschung GmbHInventors: Gerherd Hoefle, Usama Karama
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Patent number: 7144939Abstract: The use of organic based nucleating agents to induce certain specific polymer orientations into the molded polypropylene articles such that the resultant part has improved stiffness-impact properties without sacrificing other attributes of the polypropylene is provided. Such results have been obtained through the utilization of low amount of organic nucleating compounds, including, without limitation, specific metal salts of hexahydrophthalic acid (hereinafter HHPA). Furthermore, such nucleating compounds have been found to impart, again in such low added amounts, heretofore unforeseen levels of b-axis crystalline orientation which translates into improved physical properties as well.Type: GrantFiled: July 29, 2003Date of Patent: December 5, 2006Assignee: Milliken & CompanyInventors: Darin L. Dotson, Brian M. Burkhart
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Patent number: 7141694Abstract: Provided is a method of resolving a racemic mixture of a compound of formula I to obtain a desired enantiomer: wherein Ar is C6 or C10 aromatic group that can be substituted with H, C1 to C6 alkyl, trifluoromethyl or halo, R5 is halo or —S—R1, wherein R1 is H or acetyl, and R2 is H or C1 to C6 alkyl, the method comprising: reacting a compound of formula I wherein the compound is an ester whereby R2 is C1 to C6 alkyl with a lipase derived from Mucor meihei to stereoselectively hydrolyze the ester bond to produce an acid; and isolating the acid, wherein the reaction is conducted in a solvent comprising 80% to 98% v/v % organic phase and a residue of water phase (which can be buffered).Type: GrantFiled: July 23, 2003Date of Patent: November 28, 2006Assignee: Bristol-Myers Squibb CompanyInventors: Jingyang Zhu, Shannon X. Zhao
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Patent number: 7132564Abstract: The present invention provides a process for preparing cyclic 1,3-keto esters in the absence of solvent, using solid-state or high viscosity reactors.Type: GrantFiled: October 4, 2005Date of Patent: November 7, 2006Assignee: Bayer Materialscience AGInventors: Christoph Gürtler, Jörg Kirchhoff, Ido Schwarz
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Patent number: 7122684Abstract: The invention provides a multi-step process for preparing 1,2-diamino compounds of formula wherein R1, R1?, R2, R2?, R3 and R4 have the meaning given in the specification and pharmaceutically acceptable addition salts thereof, from 1,2-epoxides of formula wherein R1, R1?, R2 and R2? have the meaning given in the specification.Type: GrantFiled: March 13, 2003Date of Patent: October 17, 2006Assignee: Roche Colorado CorporationInventors: Jack D. Brown, Peter J. Harrington, Robert C. Hughes
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Patent number: 6951955Abstract: The invention is a process for the preparation of compounds of the Formula I: where R1, R2, R3, R4 and R5 are defined in the specification, which are intermediates useful for the preparation of tubulin inhibitors which are useful in the treatment of cancer.Type: GrantFiled: September 18, 2003Date of Patent: October 4, 2005Assignee: Wyeth Holdings CorporationInventors: Yanzhong Wu, Sreenivasulu Megati, Constantine Gletsos, John Thomas Kendall, Bogdan Kazimierz Wilk, Thurairajah Padmanathan, Panolil Raveendranath
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Patent number: 6909014Abstract: The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising an ether compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.Type: GrantFiled: September 5, 2003Date of Patent: June 21, 2005Assignee: Esperion Therapeutics, Inc.Inventors: Jean-Louis Henri Dasseux, Carmen Daniela Oniciu
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Patent number: 6894172Abstract: Chiral chelating agents and chiral catalysts, which are formed from the chiral chelating agents and metal, are described. One chiral chelating agent has a general formula (1) as illustrated below: wherein R represents H, methyl, ethyl, a primary, secondary or tertiary straight, branched or cyclic alkyl group having 3-7 carbon atoms, a heterocyclic or aromatic group, an aromatic group substituted at the 2-, 3- or 4-position, an aromatic-like group, or a naphthyl or naphthyl-derived group, and n is an integer between 0 and 4.Type: GrantFiled: July 1, 2003Date of Patent: May 17, 2005Assignee: National Taiwan Normal UniversityInventors: Kwunmin Chen, Kung-Shou Yang, Wei-Der Lee, Jia-Fu Pan
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Patent number: 6884821Abstract: Novel carboxylic acid derivatives of general formula (I), salts of the same, esters thereof, or hydrates of them, which are useful as insulin resistance improvers; and drugs containing the derivatives as the active ingredient. In said formula, R1 is hydrogen, hydroxyl, alkyl, or the like; L is a single bond, a double bond, alkylene, or the like; M is a single bond, alkylene, or the like; T is a single bond, alkylene, or the like; W is carboxyl, —CON(RW1)RW2, or the like; represents a single or double bond; X is oxygen, alkenylene, or the like; Y is an aromatic hydrocarbon group which may contain a heteroatom, or the like; and Z is an aromatic hydrocarbon group which may contain a heteroatom.Type: GrantFiled: September 29, 2000Date of Patent: April 26, 2005Assignee: Eisai Co., Ltd.Inventors: Masanobu Shinoda, Eita Emori, Fumiyoshi Matsuura, Toshihiko Kaneko, Norihito Ohi, Shunji Kasai, Hideki Yoshitomi, Kazuto Yamazaki, Sadakazu Miyashita, Taro Hibara, Takashi Seiki, Richard Clark, Hitoshi Harada
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Patent number: 6878723Abstract: The invention concerns compounds inhibiting LTA4 hydrolase of formula (I). The invention also concerns their therapeutic, in particular anti-inflammatory, applications.Type: GrantFiled: April 6, 2000Date of Patent: April 12, 2005Assignees: Institut National de la Sante et de la rescherche Medicale (INSERM), BioprojetInventors: Denis Danvy, Thierry Monteil, Jean-Christophe Plaquevent, Pierre Duhamel, Lucette Duhamel, Nadine Noel, Claude Gros, Olivier Chamard, Jean-Charles Schwartz, Jeanne-Marie Lecomte, Serge Piettre
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Patent number: 6861551Abstract: Disclosed are a process of subjecting a diester of a long-chain dicarboxylic acid having 18 to 21 carbon atoms to intramolecular condensation in the presence of titanium tetrachloride or zirconium tetrachloride and a trialkylamine to form an ?-alkoxycarbonylated macrocyclic ketone, and a process for producing a macrocyclic ketone by hydrolyzing an ?-alkoxycarbonylated macrocyclic ketone obtained by the process and then subjecting the hydrolyzate to decarboxylation. The invention provides a process for producing a macrocyclic ketone efficiently, which permits high concentration synthesis.Type: GrantFiled: March 28, 2001Date of Patent: March 1, 2005Assignee: Japan Energy CorporationInventors: Yoo Tanabe, Atsushi Makita
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Patent number: 6765114Abstract: The invention relates to a new process for the synthesis of 1-(aminomethyl)cyclohexyl-acetic acid of formula (I) via the new intermedier 1-(nitromethyl)cyclohexyl-acetic acid derivative of formula (II), wherein R represents hydrogen, benzyl group, diphenylmethyl group or C1-C4 alkyl or alkoxy aromatic ring substituted derivatives thereof.Type: GrantFiled: May 21, 2001Date of Patent: July 20, 2004Assignee: Richter Gedeon Vegyeszeti Gyar RT.Inventors: Tibor Gizur, Zoltanné Lengyel, Krisztina Szalai
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Patent number: 6762316Abstract: The invention relates to methods for preparing substituted cyclopentene compounds, their intermediates and use as neuraminidase inhibitors.Type: GrantFiled: May 13, 2002Date of Patent: July 13, 2004Assignee: BioCryst Pharmaceuticals, Inc.Inventors: Pooran Chand, Arthur J. Elliott
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Patent number: 6673515Abstract: The invention provides a polymer comprising recurring units of formula (1—1) or (1-2) wherein k is 0 or 1, m is 0, 1, 2, 3 or 4, and n is 1 or 2 and having a weight average molecular weight of 1,000 to 500,000. A resist composition comprising the polymer as a base resin is sensitive to high-energy radiation, has excellent sensitivity, resolution, and etching resistance, and lends itself to micropatterning with electron beams or deep-UV.Type: GrantFiled: September 14, 2001Date of Patent: January 6, 2004Assignee: Shin-Etsu Chemical Co., Ltd.Inventors: Tsunehiro Nishi, Mutsuo Nakashima, Seiichiro Tachibana, Takeshi Kinsho, Koji Hasegawa, Takeru Watanabe, Jun Hatakeyama
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Patent number: RE38659Abstract: The compounds of formula in which the symbols R1, R2, R3 and R4 represent independently from each other a hydrogen atom or a methyl or ethyl group, the symbol X represents an oxygen atom or an alkylene group of formula in which n is an integer from 1 to 3, the symbols R6 and R7 represent each a hydrogen atom or a methyl or ethyl group, and R5 represents an alkyl or alkoxy group from C1 to C4, linear or branched, an alkenyl group from C2 to C4, linear or branched, or a group of formula in which Y has the same meaning as X and R8 is a linear or branched alkyl group from C1 to C4 or a linear or branched alkenyl group from C2 to C4, are novel compounds showing musky odors and which confer musky-velvety, voluminous and very tenacious notes to the products to which they are added.Type: GrantFiled: December 23, 2002Date of Patent: November 23, 2004Assignee: Firmenich SAInventor: Alvin S. Williams