Plural Rings Bonded Directly To The Same Cyclic Carbon In Acid Moiety Patents (Class 560/36)
  • Patent number: 4075409
    Abstract: The present invention relates to pharmacologically valuable new benzophenone derivatives having a pronounced sedative action on the central nervous system and some of which also possess muscle-relaxing and aggression-inhibiting properties. These new derivatives have the structural formula ##STR1## and the pharmaceutically-acceptable acid-addition salts thereof in which R.sub.1 and R.sub.2 are substituents selected from the group consisting of hydrogen, saturated and unsaturated alkyl groups having 1-4 carbon atoms; R.sub.3 is selected from the group consisting of --COOC.sub.3 H.sub.7, --COOC.sub.4 H.sub.9, --COOC.sub.6 H.sub.5, --C.sub.6 H.sub.5, ##STR2## whereby R.sub.4 is an aliphatic radical with 1 to 4 carbon atoms or phenyl and Y is an oxygen or sulfur atom; if m is O R.sub.3 is further selected from the group consisting of --COOCH.sub.3 and --COOC.sub.2 H.sub.
    Type: Grant
    Filed: October 21, 1974
    Date of Patent: February 21, 1978
    Assignee: Cassella Farbwerke Mainkur Aktiengesellschaft
    Inventors: Heinz Gunter Greve, Klaus Resag
  • Patent number: 4072705
    Abstract: Compounds of the formula ##STR1## in which A is lower alkyl, or a substituted or unsubstituted phenyl, thienyl, furyl, indolyl or thiaindolyl radical, R, X.sub.4 and X.sub.5 are hydrogen or lower alkyl, Y is hydrogen, hydroxy, etherified hydroxy, substituted amino, or N-attached heterocyclyl, X.sub.0 is O or OCH.sub.2 CH.sub.2 O, R' represents hydrogen, lower alkyl or acetyl; and acid-addition salts thereof, are novel and useful in pharmacy as hypolipaemiant, hypocholesterolaemiant and cholagogic agents or in the preparation of such agents.
    Type: Grant
    Filed: February 9, 1976
    Date of Patent: February 7, 1978
    Assignee: Orchimed S.A.
    Inventor: Andre Mieville
  • Patent number: 4061791
    Abstract: A method of treating mammals for allergy and anaphylactic reactions of a reagin or non-reagin mediated nature which comprises administering prophylactically to said mammal an anti-allergy or anaphylactic reaction effective amount of a compound of the formula ##STR1## Novel compounds and compositions are also claimed.
    Type: Grant
    Filed: December 29, 1975
    Date of Patent: December 6, 1977
    Assignee: The Upjohn Company
    Inventors: Charles M. Hall, John B. Wright
  • Patent number: 4052514
    Abstract: Novel trihalosubstituted biphenylyl propionic and acetic acids and their derivatives are described together with processes for their preparation and composition of them. They are useful as anti-inflammatory agents.
    Type: Grant
    Filed: September 14, 1973
    Date of Patent: October 4, 1977
    Assignee: The Boots Company Limited
    Inventors: Stewart S. Adams, Bernard J. Armitage, John S. Nicholson