The Nitrogen Is In Same Side Chain As Ester Function Patents (Class 560/38)
  • Patent number: 8153688
    Abstract: Esters of 2-phenylalkanenitriles, such as 3-acetoxy-2-(2-chloro-5-(difluoromethoxy)phenyl)propanenitrile and 3-acetoxy-2-(4-chlorophenyl)propanenitrile, and compositions containing such esters, are useful as fungicides at very low concentrations.
    Type: Grant
    Filed: December 10, 2007
    Date of Patent: April 10, 2012
    Assignee: MCS Laboratories, Inc.
    Inventor: Donald Wesley Stoutamire
  • Patent number: 8110703
    Abstract: The invention relates to a retinoid derivative and pharmaceutical composition and use thereof. The compound of the invention is capable of preventing or treating hematological tumors, such as acute leukemia, chronic leukemia, multiple myeloma and lymphoma, solid tumors, such as liver cancer, rectal cancer, mammary cancer and esophagus cancer, and skin disorders, such as psoriasis and acne.
    Type: Grant
    Filed: May 31, 2009
    Date of Patent: February 7, 2012
    Assignees: Anhui Medical University, Anhui New Star Pharmaceutical Development Co., Ltd.
    Inventors: Feihu Chen, Jingbo Shi, Yuan Wang, Jun Li, Juan Shen, Jingjing Ruan, Fanrong Wu
  • Publication number: 20120016126
    Abstract: The present invention relates to an improved method for manufacturing dipeptidyl peptidase-IV inhibitor and intermediate. The present invention allows reduction of production costs by reacting low cost reagents, improves yield and is adaptable for mass production.
    Type: Application
    Filed: March 30, 2010
    Publication date: January 19, 2012
    Applicant: DONG-A PHARMACEUTICAL. CO., LTD
    Inventors: Woo Young Kwak, Heung Jae Kim, Jong Pil Min, Tae Hyun Yoon, Hyun Joo Shim, Moohi Yoo
  • Patent number: 8071783
    Abstract: A process for preparing a N-phenylisoxazolidin-5-one derivative is provided. The process for preparing the N-phenylisoxazolidin-5-one derivative comprises reacting an ?,?-unsaturated aldehyde with nitrosobenzene in the presence of a N-heterocyclic carbene (NHC) catalyst. A process for preparing an N-alkoxyphenyl protected ?-amino acid ester derivative is further provided. The process for preparing the N-alkoxyphenyl protected ?-amino acid ester derivative comprises reacting an ?,?-unsaturated aldehyde with nitrosobenzene in the presence of a N-heterocyclic carbene (NHC) catalyst to form a N-phenylisoxazolidin-5-one derivative, and then treating the N-phenylisoxazolidin-5-one derivative with an alcohol in the presence of an acid catalyst. A process for preparing an N-alkoxyphenyl protected ?-amino acid ester derivative, comprising treating a N-phenylisoxazolidin-5-one derivative with an alcohol in the presence of an acid catalyst, is also provided.
    Type: Grant
    Filed: March 14, 2008
    Date of Patent: December 6, 2011
    Assignee: Agency for Science, Technology and Research
    Inventors: Yugen Zhang, Jackie Y. Ying, Jayasree Seayad, Pranab K. Patra
  • Publication number: 20110263873
    Abstract: Provided is an enantioselective, palladium-catalyzed method for the preparation of ?-amino-?,?-unsaturated carboxylic acid derivatives having the formulas II, III, VII and VIII:
    Type: Application
    Filed: November 16, 2009
    Publication date: October 27, 2011
    Inventors: Murat Acemoglu, Andreas Pfaltz, Claude Schaerer
  • Publication number: 20110263877
    Abstract: The present invention provides novel cycloalkylmethylamine analogs, and methods of preparing cycloalkylmethylamine analogs. The present invention also provides methods of using cycloalkylmethylamine analogs and compositions of cycloalkylmethylamine analogs. The pharmaceutical compositions of the compounds of the present invention can be advantageously used for treating and/or preventing obesity and obesity related co-morbid indications.
    Type: Application
    Filed: July 5, 2011
    Publication date: October 27, 2011
    Applicant: REVIVA PHARMACEUTICALS, INC.
    Inventors: Laxminarayan Bhat, Seema Rani Bhat
  • Patent number: 7989480
    Abstract: The present invention relates to a chemical genus of 3-(triaryl)-2-aminopropanol derivative inhibitors of LTA4H (leukotriene A4 hydrolase) useful for the treatment and prevention of inflammatory diseases and disorders.
    Type: Grant
    Filed: August 3, 2007
    Date of Patent: August 2, 2011
    Assignee: Decode Genetics EHF
    Inventors: Vincent Sandanayaka, Jasbir Singh, David Sullins, Mark E. Gurney
  • Publication number: 20110178316
    Abstract: Fullerene compounds represented by the formulae Cm[C(R)CON3]n, Cm[C(R)NCO]n, Cm[C(R)NHCORd]n, and Cm[C(R)NH2]n, wherein Cm represents a fullerene moiety having m carbon atoms, m represents an even integer from about 60 to about 200, n represents an integer of about 1 or more, R represents an electron-withdrawing group, and Rd represents an alkoxy or alkylamino group. In addition, processes for preparing these fullerene compounds involving reacting an acyl azide with a fullerene in the presence of a base.
    Type: Application
    Filed: July 28, 2009
    Publication date: July 21, 2011
    Applicant: Luna Innovations Incorporated
    Inventor: Jing Zhang
  • Publication number: 20110166344
    Abstract: The invention is directed to 5,6-dihydro-1H-pyridin-2-one compounds of Formula I wherein X is N, and A is and compounds used to synthesize the compounds of Formula I.
    Type: Application
    Filed: March 8, 2011
    Publication date: July 7, 2011
    Applicant: Anadys Pharmaceuticals, Inc.
    Inventors: Chinh V. Tran, Frank Ruebsam, Douglas E. Murphy, Peter Dragovich, Yuefen Zhou, Lijian Chen, David Kucera, Fritz Blatter, Martin Viertelhaus
  • Publication number: 20110166342
    Abstract: A 7-membered heterocyclic compound having the formula (I), or its salt, or a solvate thereof with a chymase inhibitory action and useful for the prevention or treatment of various diseases, in which chymase is involved: a method for producing the same, and a pharmaceutical composition useful for the prevention or treatment of diseases, in which chymase is involved, including the compound of having the formula (I), or its pharmaceutically acceptable salt, or a solvate thereof are provided.
    Type: Application
    Filed: January 4, 2011
    Publication date: July 7, 2011
    Applicant: DAIICHI SANKYO COMPANY, LIMITED
    Inventors: Tsuyoshi Muto, Taisaku Tanaka, Hiroshi Maruoka, Seiichi Imajo, Yoshiaki Tomimori
  • Publication number: 20110137000
    Abstract: The invention relates to a process for preparing a polymeric material doped with metal elements, comprising a step of polymerization of at least one monomer comprising at least one ethylenic function, said monomer being complexed with a metal element. Use of the materials obtained by means of this process as catalysts, or luminescent or magnetic materials, or as elements for laser targets.
    Type: Application
    Filed: October 7, 2008
    Publication date: June 9, 2011
    Inventors: Balland Longeau Alexia, Moreau Louis, Thibonnet Jérôme, Velasquez Emilie
  • Patent number: 7956212
    Abstract: Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed.
    Type: Grant
    Filed: February 2, 2009
    Date of Patent: June 7, 2011
    Assignee: XenoPort, Inc.
    Inventors: Jia-Ning Xiang, Mark A. Gallop, Cindy X. Zhou, Mark Nguyen, Xuedong Dai, Jianhua Li, Kenneth C. Cundy, Nelson L. Jumbe
  • Publication number: 20110130587
    Abstract: Disclosed is a process for preparing single enantiomers of beta-amino phenylbutyric acid derivatives and pharmaceutically acceptable salts thereof, which affords the desired compounds having special optical configuration. The process comprises a step of chemical synthesis and a step of resolving the optical isomers of beta-amino phenylbutyric acid derivatives with a resolving agent. The resolving step comprises reacting the optical isomers with resolving agents, such as di-para-toluoyl-L-tartaric acid and di-para-toluoyl-D-tartaric acid. The obtained R-beta-amino phenylbutyric acid derivatives (I) have high optical purity, and the total yield of the accumulative resolution of the laevo and the dextro isomer is up to above 70%.
    Type: Application
    Filed: April 14, 2009
    Publication date: June 2, 2011
    Applicant: Jiangsu Hengrui Medicine Co., Ltd.
    Inventors: Piaoyang Sun, Yongjiang Chen, Guangliang Yu
  • Publication number: 20110104765
    Abstract: Provided herein are compositions including diastereomers in substantially diastereomerically pure form and enantiomers in substantially enantiomerically pure form, and processes for preparing them and converting them to metyrosine.
    Type: Application
    Filed: October 29, 2010
    Publication date: May 5, 2011
    Inventors: Kevin John HALLORAN, Alex COMELY, Zhengming CHEN, Shyam KRISHNAN
  • Publication number: 20110014140
    Abstract: The invention relates to an improved process for the manufacture of substitute 2-cyanocinnamic esters. This novel economical process provides products in high purity and yields.
    Type: Application
    Filed: September 24, 2010
    Publication date: January 20, 2011
    Inventors: Jing HUANG, Shuping Jing, Reinhard Karge, Ralf Proplesch
  • Publication number: 20100298559
    Abstract: There is provided a novel optically active dinickel complex and/or a production method of an optically active amine by an asymmetric Mannich reaction using the dinickel complex as a catalyst. An optically active dinickel complex of Formula (I) or Formula (I?): [where R0, R1, R2, R3, R4, R5, R6, and R7 are each independently a hydrogen atom, a halogen atom, a C1-10 alkyl group or a C1-10 alkoxy group, etc., R2 and R3 together form, together with a benzene ring bonded to them, a naphthalene ring, etc. A novel production method of an optically active amine by an asymmetric Mannich reaction using the dinickel complex as a catalyst.
    Type: Application
    Filed: December 10, 2008
    Publication date: November 25, 2010
    Applicant: NISSAN CHEMICAL INDUSTRIES, LTD.
    Inventors: Masakatsu Shibasaki, Shigeki Matsunaga, Zhihua Chen
  • Publication number: 20100261821
    Abstract: A dispersible carbon nanotube (“CNT”) comprising a CNT backbone and an organic moiety attached to the carbon nanotube backbone and comprising a hydroxyl substituted C6 to C14 aromatic group are described, as well as a CNT-polymer composite and a method of manufacturing the CNT-polymer composite.
    Type: Application
    Filed: October 13, 2009
    Publication date: October 14, 2010
    Applicants: SAMSUNG ELECTRONICS CO., LTD., KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Jong-jin PARK, Tae-gwan PARK, Yu-han LEE, Kwang-hee LEE
  • Publication number: 20100256367
    Abstract: The present invention relates to a use of a specific alpha-arylmethoxyacrylate derivative, or its pharmacologically acceptable salt or solvate for preventing and treating metabolic bone diseases.
    Type: Application
    Filed: October 14, 2009
    Publication date: October 7, 2010
    Applicants: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY, OSCOTEC INC.
    Inventors: Bum Tae KIM, Yong Ki Min, Yeon Soo Lee, Jung Nyoung Heo, Hyuk Lee, No Kyun Park, Jung-Keun Kim, Se-Won Kim, Seon-Yle Ko
  • Publication number: 20100240617
    Abstract: Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
    Type: Application
    Filed: February 15, 2010
    Publication date: September 23, 2010
    Inventors: Kevin R. Lynch, Timothy L. MacDonald, Kevin Guckian, Edward Yin-shiang Lin, Bin Ma
  • Publication number: 20100216878
    Abstract: The compound 3,3-dimethyl-butyric acid 4-((S)-2-amino-2-methoxycarbonyl-ethyl)-2-(3,3-dimethyl-butyryloxy)-phenyl ester of formula (I) has dopaminergic properties.
    Type: Application
    Filed: August 4, 2008
    Publication date: August 26, 2010
    Applicant: PROXIMAGEN LTD.
    Inventor: Christopher Hobbs
  • Publication number: 20100210607
    Abstract: The present invention relates to derivatives of non-steroidal anti-inflammatory drugs (NSAIDs) having improved anti-inflammatory properties useful in the treatment of inflammation, pain and fever. More particularly, NSAIDs are derivatized with a hydrogen sulfide (H2S) releasing moiety to produce novel anti-inflammatory compounds having reduced side effects.
    Type: Application
    Filed: February 11, 2010
    Publication date: August 19, 2010
    Applicant: ANTIBE THERAPEUTICS INC.
    Inventors: JOHN WALLACE, GIUSEPPE CIRINO, VINCENZO SANTAGADA, GIUSEPPE CALIENDO
  • Publication number: 20100204271
    Abstract: Provision of a stabilized crystal of 6-(3-chloro-2-fluorobenzyl)-1-[(S)-1-hydroxymethyl-2-methylpropyl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (compound A). A crystal of compound A, which shows a particular X-ray powder diffraction pattern of a characteristic diffraction peaks at diffraction angles 2?(°) as measured by X-ray powder diffractometry.
    Type: Application
    Filed: August 10, 2009
    Publication date: August 12, 2010
    Inventors: MOTOHIDE SATOH, TAKAHISA MOTOMURA, TAKASHI MATSUDA, KENTARO KONDO, KOJI ANDO, KOJI MATSUDA, SHUJI MIYAKE, HIDETO UEHARA
  • Patent number: 7772426
    Abstract: Disclosed is a method for efficiently and highly selectively producing L-2-amino-4-(hydroxymethylphosphinyl)-butanoic acid, which is useful as a herbicide, through a catalytic asymmetric synthesis reaction. Specifically disclosed is a method for producing L-2-amino-4-(hydroxymethylphosphinyl)-butanoic acid which is characterized in that a dehydroamino acid is subjected to an asymmetric hydrogenation by using a rhodium catalyst represented by the formula (2) below and having an optically active cyclic phosphine ligand, and then the resulting product is subjected to hydrolysis: [Rh(R4)(L)]X??(2) [where R4 represents 1,5-cyclooctadien or norbornadien; L represents a substance represented by the following formula (6): (wherein R5 and R8 respectively represent a C1-4 alkyl group; R6 and R7 respectively represent hydrogen atom or hydroxyl group; and Y represents a group selected from groups represented by the following formula (7): (where Me represents methyl group)).].
    Type: Grant
    Filed: March 28, 2006
    Date of Patent: August 10, 2010
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Nobuto Minowa, Nozomu Nakanishi, Masaaki Mitomi
  • Publication number: 20100197924
    Abstract: The present invention relates to synthetic processes for preparation of aminotetralin compounds with kinase inhibitory activity. The invention also provides synthetic intermediates useful in the processes of the invention.
    Type: Application
    Filed: December 16, 2009
    Publication date: August 5, 2010
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Alexandra E. Gould, Sean J. Harrison, Hirotake Mizutani, Ming Shen, Thomas E. Smyser, Stephen G. Stroud
  • Patent number: 7759514
    Abstract: Novel compounds and compositions including those compounds, as well as methods of using and making the compounds are herein described. The compounds are useful in therapeutic applications, including modulation of disease or disease symptoms in a subject (e.g., mammal, human, dog, cat, horse). The compounds are useful as modulators of the mu opioid receptor (MOR) through their binding affinity with that receptor.
    Type: Grant
    Filed: May 29, 2007
    Date of Patent: July 20, 2010
    Inventors: Bryce A. Harrison, Tiffany Malinky Gierasch, Gregory L. Verdine, Zhangjie Shi
  • Publication number: 20100144606
    Abstract: The invention provides a pharmaceutical product, kit or composition comprising a first active ingredient which is N-Cyclohexyl-N3-[2-(3-fluorophenyl)ethyl]-N-(2-{[2-(4-hydroxy-2-oxo-2,3-dihydro-1,3-benzothiazol-7-yl)ethyl]amino}ethyl)-?-alaninamide or a salt thereof, and a second active ingredient selected from: a non-steroidal Glucocorticoid Receptor (GR Receptor) Agonist; an antioxidant; a CCR1 antagonist; a chemokine antagonist (not CCR1); a corticosteroid; a CRTh2 antagonist; a DP1 antagonist; an Histone Deacetylase Inducer; an IKK2 inhibitor; a COX inhibitor; a lipoxygenase inhibitor; a leukotriene receptor antagonist; an MPO inhibitor; a muscarinic antagonist; a p38 inhibitor; a PDE inhibitor; a PPAR? agonist; a protease inhibitor; a Statin; a thromboxane antagonist; a vasodilator; or, an ENAC blocker (Epithelial Sodium-channel blocker); and its use in the treatment of respiratory disease (for example chronic obstructive pulmonary disease (COPD) or asthma); to certain salts of N-Cyclohexyl-N3-[2-(3-fluo
    Type: Application
    Filed: June 19, 2009
    Publication date: June 10, 2010
    Applicant: AstraZeneca AB
    Inventors: Stephen Connolly, Adrian Fisher, Alexander Humphries, Andrew Watts, Katherine Wiley
  • Patent number: 7728167
    Abstract: The present invention is concerned with the resolution of a mixture of enantiomers of N-protected amino acids by crystallization with enantiomerically pure N-unprotected ?-amino acid derivatives.
    Type: Grant
    Filed: December 9, 2004
    Date of Patent: June 1, 2010
    Assignee: Degussa AG
    Inventors: Rolf Hoffmann, Michael Kraft
  • Publication number: 20100099907
    Abstract: Methods of synthesizing a levodopa ester prodrug, salts thereof, and synthetic intermediates thereof are disclosed.
    Type: Application
    Filed: October 19, 2009
    Publication date: April 22, 2010
    Inventors: Stephen P. Raillard, Adam Mann, Suresh K. Manthati, Randall A. Scheuerman, Tono Estrada, Mark Q. Nguyen, Cindy X. Zhou
  • Publication number: 20100099898
    Abstract: Disclosed are intermediates and processes for preparing epoxides of the formula: where R and PROT are defined herein. These epoxides are useful as intermediates in the production of biologically active compounds, i.e., in the production of pharmaceutical agents.
    Type: Application
    Filed: December 23, 2009
    Publication date: April 22, 2010
    Inventor: Michael R. Reeder
  • Publication number: 20100099886
    Abstract: A process for preparing a N-phenylisoxazolidin-5-one derivative is provided. The process for preparing the N-phenylisoxazolidin-5-one derivative comprises reacting an ?,?-unsaturated aldehyde with nitrosobenzene in the presence of a N-heterocyclic carbene (NHC) catalyst. A process for preparing an N-alkoxyphenyl protected ?-amino acid ester derivative is further provided. The process for preparing the N-alkoxyphenyl protected ?-amino acid ester derivative comprises reacting an ?,?-unsaturated aldehyde with nitrosobenzene in the presence of a N-heterocyclic carbene (NHC) catalyst to form a N-phenylisoxazolidin-5-one derivative, and then treating the N-phenylisoxazolidin-5-one derivative with an alcohol in the presence of an acid catalyst. A process for preparing an N-alkoxyphenyl protected ?-amino acid ester derivative, comprising treating a N-phenylisoxazolidin-5-one derivative with an alcohol in the presence of an acid catalyst, is also provided.
    Type: Application
    Filed: March 14, 2008
    Publication date: April 22, 2010
    Inventor: Yugen Zhang
  • Publication number: 20100056780
    Abstract: The present invention relates to novel O-acyloxime derivatives, a preparation method thereof and a pharmaceutical composition comprising the same for prevention and treatment of cardiovascular disease. The O-acyloxime derivatives according to the present invention may valuably be used for prevention and treatment of cardiovascular diseases such as hyperlipidemia, coronary arterial heart disease, atherosclerosis, and myocardial infarction caused by Lp-PLA2, because they have excellent inhibitory effect of Lp-PLA2.
    Type: Application
    Filed: November 9, 2009
    Publication date: March 4, 2010
    Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Tae-Sook JEONG, Woo-Song LEE, Hyung-Jae JEONG, Yong-Dae PARK, Jong-Min HAN, Hyoung-Chin KIM, Og-Sung MOON, Young-Suk WON
  • Patent number: 7662988
    Abstract: An ester compound represented by the formula (1): has excellent pest controlling activity and is useful as an active ingredient for a pest controlling agent.
    Type: Grant
    Filed: January 16, 2007
    Date of Patent: February 16, 2010
    Assignee: Sumitomo Chemical Company, Limited
    Inventor: Tatsuya Mori
  • Publication number: 20090306384
    Abstract: The invention provides a process for producing a compound of formula (I), wherein Y is selected from the group consisting of CH3, CH2OH, CH2CH2OH, CH2Br and Br; comprising the steps of: (i) reacting a compound of formula (II), wherein OX represents hydroxy or O?M+, in which M+ is a cation selected from Li+, Na+ and K+, and Y is as defined above; with trans-cinnamaldehyde (III), in the presence of a secondary amine compound; then (ii) treating the product of the preceding step with acid to afford the compound of formula (I). The above process may also be used in the production of tolterodine and fesoterodine, which are useful in the treatment of overactive bladder.
    Type: Application
    Filed: May 21, 2007
    Publication date: December 10, 2009
    Inventors: Jens Bertil Ahman, Barry Richard Dillon, Alan John Pettman
  • Patent number: 7622504
    Abstract: Esters of 2-phenylalkanenitriles, such as 3-acetoxy-2-(2-chloro-5-(difluoromethoxy)phenyl)propanenitrile and 3-acetoxy-2-(4-chlorophenyl)propanenitrile, and compositions containing such esters, are useful as fungicides at very low concentrations.
    Type: Grant
    Filed: December 20, 2006
    Date of Patent: November 24, 2009
    Assignee: MCS Laboratories, Inc.
    Inventor: Donald Wesley Stoutamire
  • Publication number: 20090270622
    Abstract: Compounds of the formula I or I?, where the radicals R1 are each, independently of one another, a hydrogen atom or C1-C4-alkyl and R?1, is C1-C4-alkyl; X1 and X2 are each, independently of one another, a sec-phosphino group; R2 is hydrogen, R01R02R03Si— is halogen-, hydroxyl-, C1-C8-alkoxy- or R04R05N-substituted C1-C18-acyl or is R06—X01—C(O)—; R01, R02 and R03 are each, independently of one another, C1-C12-alkyl, unsubstituted or C1-C4-alkyl- or C1-C4-alkoxy-substituted C6-C10-aryl or C7-C12-aralkyl; R04 and R05 are each, independently of one another, hydrogen, C1-C12-alkyl, C3-C8-cycloalkyl, C6-C10-aryl or C7-C12-aralkyl, or R04 and R05 together are trimethylene, tetramethylene, pentamethylene or 3-oxapentylene; R06 is C1-C18-alkyl, unsubstituted or C1-C4-alkyl- or C1-C4-alkoxy-substituted C3-C8-cycloalkyl, C6-C10-aryl or C7-C12-aralkyl; X01 is —O— or —NH—; T is C-bonded C3-C20-heteroarylene; v is 0 or an integer from 1 to 4; X1 in the heteroring of the heteroarylene is bound in the ortho position relative
    Type: Application
    Filed: April 19, 2006
    Publication date: October 29, 2009
    Inventors: Martin Kesselgruber, Marc Thommen, Mathias Lotz
  • Publication number: 20090247470
    Abstract: Disclosed are a compound of formula I, stereoisomers, pharmaceutically acceptable salts or hydrates thereof, a pharmaceutical composition comprising the smae, a process for preparing the same and use thereof. The compound may also be used to prepare a medicament to treat viral infections, especially to prepare a medicament to treat hepatitis B virus and human immunodeficiency virus with little toxic side effects.
    Type: Application
    Filed: March 27, 2008
    Publication date: October 1, 2009
    Applicants: The Key Lab. Of Chemistry for Natural Products of Guizhou Province and Chinese Acad. of Sciences, Tianjin Institute of Pharmaceutical Research, 302 Hospital of PLA, China
    Inventors: Guangyi Liang, Bixue Xu, Changxiao Liu, Zhengming Huang, Peixue Cao, Zegui Cai, Yuming Liu
  • Patent number: 7569720
    Abstract: This invention relates to newly identified ester-linked gemini surfactant compounds, to the use of such compounds and to their production. The invention also relates to the use of the ester-linked gemini surfactant compounds to facilitate the transfer of polynucleotides into cells.
    Type: Grant
    Filed: August 4, 2008
    Date of Patent: August 4, 2009
    Assignee: Glaxo Group Limited
    Inventors: Mariano Javier Castro, Christopher Kitson, Mark Ladlow, Alpesh Patel
  • Publication number: 20090170936
    Abstract: An ester compound represented by the formula (1): has excellent pest controlling activity and is useful as an active ingredient for a pest controlling agent.
    Type: Application
    Filed: January 16, 2007
    Publication date: July 2, 2009
    Inventor: Tatsuya Mori
  • Publication number: 20090143465
    Abstract: An ester compound represented by the formula (I): has excellent pest controlling activity and is useful as an active ingredient for a pest controlling agent.
    Type: Application
    Filed: April 27, 2007
    Publication date: June 4, 2009
    Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventor: Tatsuya Mori
  • Publication number: 20090105091
    Abstract: The present invention provides a compound of the general formula (I), wherein X is the connection between the CO-hydrazine and the NR1-oxalic acid or ester group, and uses and synthesis methods. These compounds represent amino acid derivatives, wherein the amine group is turned into an acidic group by the oxalic acid group and the carboxylic acid is turned into an amine functionality by the hydrazine group; as well as peptidomimetics comprising the compound and methods for their synthesis.
    Type: Application
    Filed: November 24, 2006
    Publication date: April 23, 2009
    Applicant: TECHNISCHE UNIVERSITAT WIEN
    Inventors: Ulrich Jordis, Jaywant B. Phopase
  • Patent number: 7514578
    Abstract: The invention relates to a method for producing enantiomeris form of 2, 3-diaminopropionic acid derivatives of formula (I) by asymetric hydrogenation from compounds of formula (II).
    Type: Grant
    Filed: January 10, 2007
    Date of Patent: April 7, 2009
    Assignee: sanofi-aventis Deutschland GmbH
    Inventors: Joerg Rieke-Zapp, Guenter Billen
  • Publication number: 20090054679
    Abstract: The present invention provides a method for producing asymmetrical mono-substituted alkylated compounds of ?-amino acids that are represented by a specific formula, using an aldimine-type Schiff base. In the method of the present invention, the process of alkylating an aldimine-type Schiff base in a medium in the presence of an optically-active quaternary ammonium salt phase-transfer catalyst and an inorganic base is initiated, and subsequently the reaction is quenched at a time earlier than a time for completion of the stoichiometric reaction of the alkylation reaction, so that a mono-substituted alkylated product with high optical purity can be obtained.
    Type: Application
    Filed: July 28, 2006
    Publication date: February 26, 2009
    Applicant: NAGASE & CO., LTD.
    Inventors: Keiji Maruoka, Toru Inoue, Jun Matsumoto
  • Publication number: 20090036523
    Abstract: Described herein are cannabidiol prodrugs, methods of making cannabidiol prodrugs, formulations comprising cannabidiol prodrugs and methods of using cannabidiols. One embodiment described herein relates to the transdermal or topical administration of a cannabidiol prodrug for treating and preventing diseases and/or disorders.
    Type: Application
    Filed: July 30, 2008
    Publication date: February 5, 2009
    Applicant: AllTranz Inc.
    Inventors: Audra Lynn Stinchcomb, Miroslaw Jerzy Golinski, Dana Carmel Hammel, Jeffery Lynn Howard, Stan Lee Banks
  • Publication number: 20090018189
    Abstract: Disclosed herein are compound useful for inhibition of hormone sensitive lipase, pharmaceutical compositions of these compounds, and methods of treatment using these compounds.
    Type: Application
    Filed: June 26, 2008
    Publication date: January 15, 2009
    Inventors: Jean-Frederic Sauniere, Yat S. Or
  • Publication number: 20090011475
    Abstract: Disclosed is a method for production of an optically active biphenylalanine compound represented by the formula (2): (wherein, R2 is a protective group of an amino group, and R3 and R4 are each independently a hydrogen atom, etc.) or a salt thereof and an optically active biphenylalanine ester compound represented by the formula (3): (wherein, R1 is an alkyl group, etc.) wherein the method comprises hydrolyzing a biphenylalanine ester compound represented by the formula (1): with a protease produced by a microorganism belonging to Bacillus sp. in the presence of at least one alkali selected from an alkali metal hydroxide and an alkaline earth metal hydroxide.
    Type: Application
    Filed: January 15, 2007
    Publication date: January 8, 2009
    Inventors: Kiyoshi Sugi, Masahide Tanaka, Yoshihiro Kawada, Daisuke Sasayama
  • Publication number: 20080293678
    Abstract: The invention describes compositions and kits comprising at least qrie organic nitric oxide enhancing salt of an angiotensin converting enzyme inhibitor, and, optionally, at least one nitric oxide enhancing compound and/or at least one therapeutic agent. The invention also provides methods for (a) treating cardiovascular diseases; (b) treating renovascular diseases; (c) treating diabetes; (d) treating diseases resulting from oxidative stress; (e) treating endothelial dysfunctions; (f) treating diseases caused by endothelial dysfunctions; (g) treating cirrhosis; (h) treating pre-eclampsia; Q) treating osteoporosis; (k) treating nephropathy; (l) treating peripheral vascular diseases; (m) treating portal hypertension; (n) treating ophthalmic disorders; (o) treating metabolic syndrome; and (p) treating hyperlipidemia.
    Type: Application
    Filed: March 17, 2006
    Publication date: November 27, 2008
    Applicant: NitroMed, Inc.
    Inventor: David S. Garvey
  • Publication number: 20080171004
    Abstract: The present invention relates to the use of compounds which do not themselves exhibit significant UV absorption in the UV-A or UV-B region, but are reactive under use conditions, for the development of UV-A or UV-B protection during use, to corresponding novel compounds and compositions, and to corresponding processes for the preparation of compounds and compositions.
    Type: Application
    Filed: March 21, 2006
    Publication date: July 17, 2008
    Inventors: Thomas Rudolph, Herwig Buchholz
  • Patent number: 7381745
    Abstract: The present invention relates to novel compounds and formulations thereof which compounds are ligands, e.g., agonists or antagonists, for a metabotropic glutamate receptor or a NAALADase enzyme or both. The present invention also relates to methods of modulating the activity of a metabotropic glutamate receptor or a NAALADase enzyme or both, e.g., in a subject in need thereof, using a compound or formulation of the present invention. The present invention also relates to methods of treating a subject suffering from a chronic or acute disease, malady or condition due at least in part to an abnormality in the activity of an endogenous metabotropic glutamate receptor or a NAALADase enzyme or both, using a compound or formulation of the present invention.
    Type: Grant
    Filed: February 25, 2003
    Date of Patent: June 3, 2008
    Assignee: Georgetown University
    Inventors: Alan P. Kozikowski, Jarda T. Wroblewski, Fajun Nan
  • Patent number: 7375245
    Abstract: The present invention provides a compound of the following formula (I): wherein R1 is methyl or 4-aminobutyl, which may be acylated; X is phenyl or substituted phenyl; W is an esterified group removable by hydrogenolysis. Also disclosed is the preparation method and the application of formula (I) compound.
    Type: Grant
    Filed: July 7, 2004
    Date of Patent: May 20, 2008
    Assignee: Everlight USA, Inc.
    Inventors: Yu-Liang Liu, Rung-Tian Suen, Ying-Chi Chiu
  • Patent number: RE40480
    Abstract: The invention relates to compounds of formula: wherein R1 is selected from the group consisting of fatty acid acyl groups of 12 to 30 carbon atoms and fatty alcohol groups of 12 to 30 carbon atoms, and wherein R2 is selected from the group consisting of H, fatty acid acyl of 12 to 30 carbon atoms and fatty alcohol groups of 12 to 30 carbon atoms, the same as or different from R1, and the residue of a nutrient, drug, or other bioactive compound, and to the use of these compounds to deliver drugs and other bioactive compounds.
    Type: Grant
    Filed: May 1, 1996
    Date of Patent: September 2, 2008
    Assignee: Scarista Limited
    Inventors: Sherri Clarkson, Mehar Manku, Philip Knowles, Peter Redden, Andrea Pitt, Paul Bradley, Paul Wakefield, Austin McMordie, David B. Horrobin