Plural Rings Bonded Directly To The Same Carbonyl In Acid Moiety Patents (Class 560/52)
-
Patent number: 10392356Abstract: Ester derivatives of sobetirome with enhanced CNS distribution are disclosed.Type: GrantFiled: June 6, 2017Date of Patent: August 27, 2019Assignee: OREGON HEALTH & SCIENCE UNIVERSITYInventors: Thomas S. Scanlan, Andrew Placzek, Tapasree Banerji, Sky Ferrara, James Matthew Meinig
-
Publication number: 20150148441Abstract: The present invention provides polymeric photoinitiators being co-polymers of photoinitiator monomers and at least one further monomer, as well as photoinitiator monomers being intermediates in the preparation of such polymeric photoinitiators. Additionally, there is provided polyacrylate obtained by radical polymerization of at least one acrylate monomer (Ac) in the presence of such polymeric photoinitiators. In the photoinitiator monomers and polymeric photoinitiators, a photoinitiator moiety, a hydrolytic stable linker and two polymerisable functional groups are incorporated into the photoinitiator structure.Type: ApplicationFiled: May 14, 2013Publication date: May 28, 2015Inventors: Niels Joergen Madsen, Petr Sehnal, David George Anderson, Bo Rud Nielsen
-
Publication number: 20150141479Abstract: The invention relates to the compounds of formula I and formula II or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I or formula II, and methods for treating or preventing or modulating moderate to severe pain in a disease may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection.Type: ApplicationFiled: February 4, 2013Publication date: May 21, 2015Inventor: Mahesh Kandula
-
Publication number: 20150126576Abstract: The present invention relates to compounds that may be used to inhibit activation of protein kinase G (“PKG”). It is based, at least in part, on the discovery of the tertiary structure of PKG and the identification of molecules that either bind to the active site of PKG and/or are analogs of balanol.Type: ApplicationFiled: September 29, 2014Publication date: May 7, 2015Applicant: The Trustees of Columbia University in the City of New YorkInventors: Richard Ambron, Ying-Ju Sung, Jeremy Greenwood, Leah Frye, Shi-Xian Deng, Yuli Xie, Donald W. Landry
-
Publication number: 20150057238Abstract: Certain compounds, or pharmaceutically acceptable salts or prodrugs thereof, are provided herein. Also provided are pharmaceutical compositions comprising at least one compound, or pharmaceutically acceptable salt or prodrug thereof, described herein and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of KMO activity are described, which comprise administering to such patients an amount of at least one compound, or pharmaceutically acceptable salt or prodrug thereof, described herein effective to reduce signs or symptoms of the disease or disorder are disclosed. These diseases include neurodegenerative disorders such as Huntington's disease.Type: ApplicationFiled: March 13, 2013Publication date: February 26, 2015Inventors: Leticia M. Toledo-Sherman, Celia Dominguez, Michael Prime, William Leonard Mitchell, Peter Johnson, Naomi Went
-
Publication number: 20140078878Abstract: The present invention provides a non-resonant two-photon absorption recording material containing a non-resonant polymer two-photon absorption compound, and the non-resonant two-photon absorption recording material wherein the main chain of the non-resonant polymer two-photon absorption compound contains at least one member selected from polystyrene, polyacrylate, polymethacrylate, polyester, polyurethane, polyether and polyimide, and also provides an optical information recording medium having a recording layer containing the recording material.Type: ApplicationFiled: November 13, 2013Publication date: March 20, 2014Applicant: FUJIFILM CORPORATIONInventors: Hiroaki TSUYAMA, Masaomi MAKINO, Hidehiro MOCHIZUKI, Toshio SASAKI, Tatsuo MIKAMI
-
Publication number: 20130310595Abstract: The present invention provides a compound useful as a synthetic intermediate for an anti-HIV agent having an integrase inhibitory activity, and a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate. Specifically, for example, a compound represented by the formula (2?): wherein R is a fluorine atom or a methoxy group, and R400 is a hydrogen atom or a C1-C4 alkyl group, or a salt thereof, and a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate.Type: ApplicationFiled: November 21, 2012Publication date: November 21, 2013Applicant: JAPAN TOBACCO INC.Inventor: Japan Tobacco Inc.
-
Publication number: 20130303797Abstract: The present invention is a method for preparing triterpenoids such as 2-cyano-3,12-dioxoolean-1,9-dien-28-methyl ester and derivatives thereof from oleanic acid, ursolic acid, betulinic acid, sumaresinolic acid or hederagenin.Type: ApplicationFiled: May 8, 2012Publication date: November 14, 2013Applicant: Trustees of Dartmouth CollegeInventors: Gordon W. Gribble, Liangfeng Fu
-
Patent number: 8541398Abstract: The present invention relates to derivatives of non-steroidal anti-inflammatory drugs (NSAIDs) having improved anti-inflammatory properties useful in the treatment of inflammation, pain and fever. More particularly, NSAIDs are derivatized with a hydrogen sulfide (H2S) releasing moiety to produce novel anti-inflammatory compounds having reduced side effects.Type: GrantFiled: February 11, 2010Date of Patent: September 24, 2013Assignee: Antibe Therapeutics Inc.Inventors: John L. Wallace, Giuseppe Cirino, Vincenzo Santagada, Giuseppe Caliendo
-
Publication number: 20130224318Abstract: The present invention describes methods for improving the appearance of skin, particularly, treating, ameliorating, preventing, delaying, and/or improving one or more signs of excess accumulation and/or production of subcutaneous fat, such as cellulite, and conditions related thereto, by topically applying compositions comprising Carnitine Palmitoyl Transferase-1 (CPT-1) modulators, optionally with other anti-lipid agents; and also describes compositions and methods for treating, preventing and improving the appearance of skin, particularly, treating, preventing, ameliorating, reducing and/or eliminating loss of subcutaneous fat in the skin, wherein the compositions include natural plant constituents that stimulate lipid synthesis.Type: ApplicationFiled: February 26, 2013Publication date: August 29, 2013Applicant: Avon Products, Inc.Inventor: Avon Products, Inc.
-
Publication number: 20130217877Abstract: The present invention discloses novel aromatic ketone compounds with functional substiution groups at para- or meta positions which can be used as photo-initiators or effective components of photo-initiator mixtures for the photopolymerizations of ethylenically unsaturated systems. The preparation of these compounds is also disclosed.Type: ApplicationFiled: November 4, 2011Publication date: August 22, 2013Applicant: SHENZHEN UV-CHEMTECH CO., LTDInventors: Yongbo Zhang, Yanchao Wang, Yapeng Wang, Huaihai Song, Zhigang Wang
-
Patent number: 8445715Abstract: A novel process for the synthesis of fenofibrate, includes reacting a metal salt of fenofibric acid with an isopropyl halide, in a solvent system composed of a mixture of dimethyl sulfoxide and a C2-C4 alkyl acetate. The process can be used on an industrial scale and makes it possible to obtain a fenofibrate of a quality in accordance with the Pharmacopoeia without the need for purification by recrystallization.Type: GrantFiled: July 2, 2008Date of Patent: May 21, 2013Assignee: SynkemInventor: Beatrice Lucas
-
Patent number: 8389769Abstract: A polymerizable Type II photoinitiator according to Formula (I): wherein: A represents a Norrish Type II initiating group; L represents a divalent linking group positioning the Norrish Type II initiating group A and the CR2R3-group in a 1-5 to a 1-8 position wherein position 1 is defined as the first atom in the aromatic or alicyclic ring of A to which L is covalently bonded and the position 5 to 8 is defined as the carbon atom of the CR2R3-group to which L is covalently bonded, with the proviso that L does not contain an amine. Radiation curable compositions and inks include the multifunctional Type II photoinitiator.Type: GrantFiled: May 28, 2009Date of Patent: March 5, 2013Assignee: Agfa Graphics NVInventors: Johan Loccufier, Jaymes Van Luppen
-
Patent number: 8362101Abstract: A multifunctional Type II photoinitiator according to Formula (I): wherein X represents a structural moiety according to Formula (II): wherein: A represents a Norrish Type II initiating group; and L represents a divalent linking group positioning the Norrish Type II initiating group A and the CR2R3-group in a 1-5 to a 1-9 position wherein position 1 is defined as the first atom in the aromatic or alicyclic ring of A to which L is covalently bonded and the position 5 to 9 is defined as the carbon atom of the CR2R3-group to which L is covalently bonded, with the proviso that L does not contain an amine. Radiation curable compositions and inks include the multifunctional Type II photoinitiator.Type: GrantFiled: May 28, 2009Date of Patent: January 29, 2013Assignee: Agfa Graphics NVInventors: Johan Loccufier, Jaymes Van Luppen
-
Patent number: 8288580Abstract: A benzophenone compound is represented by the following formula (I): (A)n-X—(B)m??(I) wherein X is an organic moiety having (n+m) valence, (n+m) being an integer ranging from 1 to 4; A is B is R is H or a methyl group; n is the number of A bonded to X and is an integer ranging from 1 to 4; and m is the number of B bonded to X and is an integer ranging from 0 to 3.Type: GrantFiled: November 9, 2010Date of Patent: October 16, 2012Assignee: Double Bond Chemical Ind. Co., Ltd.Inventors: Jimmy Liu, Kuei-Ta Chen, I-Ling Chen
-
Publication number: 20120171397Abstract: Resin plasticizers are produced by esterification of keto acids derived from acylation of aromatic compounds with cyclic anhydrides, and are particularly useful in making phthalate-free articles using PVC.Type: ApplicationFiled: June 21, 2010Publication date: July 5, 2012Inventors: Karla S. Colle, Jorg F. Weber, Allen D. Godwin
-
Publication number: 20120141788Abstract: The present invention relates a process for the precipitation of an organic compound, wherein: (a) a solution (I) of the organic compound in a first solvent is introduced via a first inlet into a closed type mixing chamber; (b) a precipitation agent (II) is introduced, simultaneously with step (a), via a second inlet into the closed type of mixing chamber; (c) the solution (I) of the organic compound and the precipitating agent (II) are mixed thereby forming a precipitate of the organic compound and a liquid phase; and (d) discharging the precipitate of the organic compound and the liquid phase via a single outlet from the closed type mixing chamber.Type: ApplicationFiled: September 19, 2007Publication date: June 7, 2012Inventor: Huibert Albertus Van Boxtel
-
Publication number: 20120076953Abstract: Disclosed therein is a novel cyclic olefin compound having a photoreactive group and a novel photoreactive polymer. The cyclic olefin compound is applicable to various photoreactions, such as of liquid crystal alignment films and can be preferably used as a precursor of different organic compounds or polymers.Type: ApplicationFiled: September 21, 2011Publication date: March 29, 2012Inventors: Dai-Seung CHO, Sung-Ho Chun, Young-Chul Won, Dong-Woo Yoo
-
Publication number: 20120070511Abstract: Compositions which modulate mitochondrial functions treat diseases associated with cells that are hyperactively using their endoplasmic reticulum. Screening assays identify agents which modulate mitochondrial functions.Type: ApplicationFiled: September 21, 2011Publication date: March 22, 2012Applicant: UNIVERSITY OF MIAMIInventors: Theodore Lampidis, Metin Kurtoglu
-
Publication number: 20120065421Abstract: A novel process for the synthesis of fenofibrate, includes reacting a metal salt of fenofibric acid with an isopropyl halide, in a solvent system composed of a mixture of dimethyl sulfoxide and a C2-C4 alkyl acetate. The process can be used on an industrial scale and makes it possible to obtain a fenofibrate of a quality in accordance with the Pharmacopoeia without the need for purification by recrystallization.Type: ApplicationFiled: July 2, 2008Publication date: March 15, 2012Applicant: SYNKEMInventor: Béatrice Lucas
-
Publication number: 20110282091Abstract: A benzophenone compound is represented by the following formula (I): (A)n-X—(B)m??(I) wherein X is an organic moiety having (n+m) valence, (n+m) being an integer ranging from 1 to 4; A is B is R is H or a methyl group; n is the number of A bonded to X and is an integer ranging from 1 to 4; and m is the number of B bonded to X and is an integer ranging from 0 to 3.Type: ApplicationFiled: November 9, 2010Publication date: November 17, 2011Applicant: Double Bond Chemical Ind. Co., Ltd.Inventors: Jimmy Liu, Kuei-Ta Chen, I-Ling Chen
-
Publication number: 20110237665Abstract: The present invention relates to an agrochemical composition comprising pesticide and UV absorber, and the abovementioned UV absorbers. The invention furthermore relates to the use of the UV absorbers in agrochemical compositions. It moreover relates to a method of controlling phytopathogenic fungi and/or undesirable plant growth and/or undesirable insect or mite infestation and/or of regulating plant growth.Type: ApplicationFiled: November 30, 2009Publication date: September 29, 2011Applicant: BASF SEInventors: Andrea Misske, Christian Bittner, Michael Ishaque, Markus Hoffmann, Richard Riggs, Sens Ruediger, Andre Kabat, Sylke Haremza, Douglas D. Anspaugh, David M. Terry
-
Patent number: 8017789Abstract: A preparation method using as an intermediate 6-(halomethyl)-1,2-benzisoxazol-3(2H)-one derivative represented by general formula wherein R5 is a methyl group that is substituted with one or more optionally substituted phenyl groups, or an optionally substituted oxygen-containing heterocyclic group; X represents a halogen atom, can be used as a method for safely and easily preparing 3-{5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-hydroxy-1,2-benzisoxazol-6-yl)methoxy]phenyl}propionic acid, which is useful as an antirheumatic agent, with a high yield.Type: GrantFiled: February 19, 2007Date of Patent: September 13, 2011Assignee: Toyama Chemical Co., Ltd.Inventors: Kenji Yonezawa, Tamotsu Takamatsu, Naokatu Aoki, Tomohiro Hashimoto, Masahiro Takebayashi, Yoshiaki Suzuki, Yuji Oonishi
-
Publication number: 20110160225Abstract: Disclosed herein are novel compositions and methods for treating or preventing a variety of disorders and conditions associated with lipid metabolism. The methods generally include administering to a patient in need thereof a therapeutically effective amount of a pharmaceutical composition comprising one or more fibric acid or statin derivative compositions alone or in combination with one or more lipid altering agents and/or PDE inhibitors.Type: ApplicationFiled: November 19, 2010Publication date: June 30, 2011Applicant: IRONWOOD PHARMACEUTICALS, INC.Inventors: Mark G. Currie, John Jeffrey Talley, Brian Cali
-
Publication number: 20110144373Abstract: Described herein is a degradable linking agent that includes a core molecule with one or more charged groups; and one or more photoreactive groups covalently attached to the core molecule by one or more degradable linkers.Type: ApplicationFiled: December 10, 2010Publication date: June 16, 2011Applicant: SurModics, Inc.Inventors: Dale G. Swan, Emily Rose Rolfes Meyering, Aleksey V. Kurdyumov, Peter H. Duquette, Robert W. Hergenrother, Toni M. Heyer
-
Patent number: 7939245Abstract: The present invention relates to a light absorbent for organic anti-reflection coating formation, and an organic anti-reflection film composition containing the same. The light absorbent for organic anti-reflection film formation according to the present invention is a compound of the following formula (1a), a compound of the following formula (1b), a mixture of compounds of the formulas (1a) and (1b): wherein X is selected from the group consisting of a substituted or unsubstituted cyclic group having 1 to 20 carbon atoms, aryl, diaryl ether, diaryl sulfide, diaryl sulfoxide and diaryl ketone; and R1 is a hydrogen atom, a substituted or unsubstituted alkyl group having 1 to 10 carbon atoms, or an aryl group having 1 to 14 carbon atoms.Type: GrantFiled: June 13, 2008Date of Patent: May 10, 2011Assignee: Korea Kumho Petrochemical Co., Ltd.Inventors: Joo-Hyeon Park, Ji-Young Kim, Jun-Ho Lee
-
Publication number: 20110069130Abstract: A multifunctional Type II photoinitiator according to Formula (I): wherein X represents a structural moiety according to Formula (II): wherein: A represents a Norrish Type II initiating group; and L represents a divalent linking group positioning the Norrish Type II initiating group A and the CR2R3-group in a 1-5 to a 1-9 position wherein position 1 is defined as the first atom in the aromatic or alicyclic ring of A to which L is covalently bonded and the position 5 to 9 is defined as the carbon atom of the CR2R3-group to which L is covalently bonded, with the proviso that L does not contain an amine. Radiation curable compositions and inks include the multifunctional Type II photoinitiator.Type: ApplicationFiled: May 28, 2009Publication date: March 24, 2011Applicant: AGFA GRAPHICS NVInventors: Johan Loccufier, Jaymes Van Luppen
-
Publication number: 20100210607Abstract: The present invention relates to derivatives of non-steroidal anti-inflammatory drugs (NSAIDs) having improved anti-inflammatory properties useful in the treatment of inflammation, pain and fever. More particularly, NSAIDs are derivatized with a hydrogen sulfide (H2S) releasing moiety to produce novel anti-inflammatory compounds having reduced side effects.Type: ApplicationFiled: February 11, 2010Publication date: August 19, 2010Applicant: ANTIBE THERAPEUTICS INC.Inventors: JOHN WALLACE, GIUSEPPE CIRINO, VINCENZO SANTAGADA, GIUSEPPE CALIENDO
-
Publication number: 20100184946Abstract: A process and device for the precipitation of an organic compound comprising the steps: (a) providing a first stream comprising an organic compound and a solvent for the organic compound; (b) providing a second stream comprising an anti-solvent for the organic compound; (c) providing a third stream comprising a second stabilising agent; (d) intermixing the first and second streams to form a precipitate of the organic compound in particulate form; and (e) following step (d), intermixing the third stream with the intermixed first and second streams containing the precipitated organic compound in particulate form wherein the first and/or the second stream comprises a first stabilising agent.Type: ApplicationFiled: July 17, 2008Publication date: July 22, 2010Inventor: Huibert Albertus Van Boxtel
-
Publication number: 20100183974Abstract: A compound of the present invention is a compound represented by a general formula (A-1) [wherein, R? represents a hydrogen atom or an acid-dissociable, dissolution-inhibiting group, provided that at least one R? group is an acid-dissociable, dissolution-inhibiting group, R11 to R17 each represent an alkyl group of 1 to 10 carbon atoms or an aromatic hydrocarbon group, which may include a hetero atom within the structure; g and j each represent an integer of 1 or greater, and k and q each represent an integer of 0 or greater, provided that g+j+k+q is not greater than 5; a represents an integer from 1 to 3; b represents an integer of 1 or greater, and l and m each represent an integer of 0 or greater, provided that b+l+m is not greater than 4; c represents an integer of 1 or greater, and n and o each represent an integer of 0 or greater, provided that c+n+o is not greater than 4; and A represents a group represented by a general formula (Ia) shown below, a group represented by a general formula (Ib) shown beloType: ApplicationFiled: September 13, 2006Publication date: July 22, 2010Applicant: Tokyo Ohka Kogyo Co., Ltd.Inventors: Daiju Shiono, Takahiro Dazai, Taku Hirayama, Kohei Kasai, Hideo Hada
-
Publication number: 20100185008Abstract: Method for producing fenofibrate from fenofibric acid by in situ preparation of fenofibric acid chloride by means of the action of a chlorinating agent on the acid then by reaction with isopropanol without isolation of the acid chloride.Type: ApplicationFiled: July 7, 2008Publication date: July 22, 2010Applicant: FINORGAInventor: Valery Dambrin
-
Publication number: 20100105937Abstract: Disclosed is a compound represented by Formula (1). In Formula (1), * represents an asymmetric carbon atom; L and L? each independently represent a divalent linking group; Rd represents an oxidation-reduction reaction causing portion; B and B? each independently represent a liquid crystal substituent; D represents an arylene group, a hetero arylene group, or a divalent alicyclic hydrocarbon group; R represents a substituent; x represents 0 or 1; z represents an integer of from 0 to 3; w represents 0 or 1; n represents 0 or 1; v represents an integer of from 0 to 5; when z is 2 or more, plural B?s may be the same or different; and when v is 2 or more, plural R?s may be the same or different.Type: ApplicationFiled: October 26, 2009Publication date: April 29, 2010Inventor: Koji TAKAKU
-
Publication number: 20100099580Abstract: Compounds and methods for controlling the surface properties are described. Compounds of the invention can form radicals upon exposure to irradiation, which can then react with nearby molecules to alter the surface properties of various substrates. The invention can provide surfaces that are resistant to dewetting, surfaces that have immobilized molecules such as carbohydrates and polymers immobilized, and surfaces that have metals deposited on the surface. The invention can be utilized in a wide range of application, such as sensors, microreactors, microarrays, electroless deposition of metals, and the like.Type: ApplicationFiled: November 9, 2006Publication date: April 22, 2010Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Gregory T. Carroll, Jeffrey T. Koberstein, Denong Wang, Nicholas J. Turro
-
Publication number: 20090306339Abstract: A process for the precipitation of an organic compound comprising mixing simultaneously introduced streams of a solution and a precipitation agent in a chamber using a mechanical stirrer in the presence of an amphiphilic polymer. The process may be operated in a continuous manner and is particularly useful for providing low solubility organic compounds (e.g. pharmaceuticals) in readily dispersible, nano-sized particulate form up to manufacturing scale.Type: ApplicationFiled: July 20, 2007Publication date: December 10, 2009Inventor: Huibert Albertus Van Boxtel
-
Patent number: 7598242Abstract: This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, TNF-? or combinations thereof.Type: GrantFiled: October 20, 2005Date of Patent: October 6, 2009Assignee: Schering CorporationInventors: Zhaoning Zhu, Robert Mazzola, Zhuyan Guo, Brian J. Lavey, Lisa Sinning, Joseph Kozlowski, Brian McKittrick, Neng-Yang Shih
-
Publication number: 20090234150Abstract: The present invention relates to the field of muscle pathologies, more particularly to the field of diseases where skeletal muscle damage and muscle loss occurs. The invention shows that peroxisome proliferator-activated receptor (PPAR)-alpha agonists, such as fibrates, can be used to prevent skeletal muscle degeneration, more particularly ischemic skeletal muscle degeneration.Type: ApplicationFiled: July 10, 2007Publication date: September 17, 2009Inventor: Peter Carmeliet
-
Publication number: 20090187040Abstract: Disclosed are new methods of making the fenofibric acid polymorphs as well as formulations prepared therefrom and uses thereof.Type: ApplicationFiled: January 15, 2009Publication date: July 23, 2009Inventors: Tong Sun, Michael L. Hall, Paul K. Isbester, Brent R. Whitehead
-
Publication number: 20090099369Abstract: A preparation method using as an intermediate 6-(halomethyl)-1,2-benzisoxazol-3(2H)-one derivative represented by general formula wherein R5 is a methyl group that is substituted with one or more optionally substituted phenyl groups, or an optionally substituted oxygen-containing heterocyclic group; X represents a halogen atom, can be used as a method for safely and easily preparing 3-{5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-hydroxy-1,2-benzisoxazol-6-yl)methoxy]phenyl}propionic acid, which is useful as an antirheumatic agent, with a high yield.Type: ApplicationFiled: February 19, 2007Publication date: April 16, 2009Applicant: TOYAMA CHEMICAL CO., LTD.Inventors: Kenji Yonezawa, Tamotsu Takamatsu, Naokatu Aoki, Tomohiro Hashimoto, Masahiro Takebayashi, Yoshiaki Suzuki, Yuji Oonishi
-
Publication number: 20090054450Abstract: Disclosed herein are novel compositions and methods for treating or preventing a variety of disorders and conditions associated with lipid metabolism. The methods generally include administering to a patient in need thereof a therapeutically effective amount of a pharmaceutical composition comprising one or more fibric acid or statin derivative compositions alone or in combination with one or more lipid altering agents and/or PDE inhibitors.Type: ApplicationFiled: June 17, 2008Publication date: February 26, 2009Applicant: IRONWOOD PHARMACEUTICALS, INC.Inventors: Mark G. CURRIE, John Jeffrey TALLEY, Brian CALI
-
Publication number: 20090030077Abstract: The invention provides novel omega-3 oil liquid formulations of fenofibrate. These formulations can be substantially free of any food effect, effective in small volumes, and readily bioavailable. Notably, because the formulations of the invention contain an omega-3 oil as the major ingredient, they not only provide anithypercholesterolemic and antihypertriglyceridemic effects due to the fenofibrate active ingredient, they also provide recommended daily dosages of omega-3 oils (i.e., approximately 1 gram of omega-3 oil per day), or a portion thereof.Type: ApplicationFiled: August 1, 2008Publication date: January 29, 2009Applicant: Transform Pharmaceuticals Inc.Inventors: Orn Almarsson, Pasut Ratanabanangkoon, Julius Remenar, Hector Guzman
-
Publication number: 20080306151Abstract: The present application describes deuterium-enriched fenofibrate, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.Type: ApplicationFiled: June 11, 2007Publication date: December 11, 2008Applicant: PROTIA, LLCInventor: Anthony W. Czarnik
-
Patent number: 7314888Abstract: A compound or a salt thereof having the atom corresponding to N3 and the two or more atoms selected from N1, N2, N4 and N5, said atoms constitute the pharmacophore represented by the following formula: and inhibits the activity of transcription factor AP-1 and is useful as an agent for preventing and treating the diseases into which over expression of AP-1 participates and as an AP-1 inhibitor.Type: GrantFiled: November 5, 1999Date of Patent: January 1, 2008Assignee: Toyama Chemical Co., Ltd.Inventors: Hisaaki Chaki, Tadakazu Takakura, Keiichi Tsuchida, Hironori Kotsubo, Yukihiko Aikawa, Shuichi Hirono, Shunichi Shiozawa
-
Patent number: 7166647Abstract: Compounds of formula (I): {where n is a number from 1 to 6; R3 is hydrogen, methyl or ethyl; A represents a group of formula —[O(CHR2CHR1)a]y—, —[O(CH2)bCO]y—, or —[O(CH2)bCO](y?1)—[O(CHR2CHR1)a]— (where one of R1 and R2 is hydrogen and the other is hydrogen, methyl or ethyl); a is from 1 to 2; b is from 4 to 5; y is from 3 to 10; Q is a residue of a polyhydroxy compound having 2 to 6 hydroxy groups; and x is greater than 1 but no greater than the number of available hydroxyl groups in Q} and esters thereof are useful as photoinitiators for the preparation of energy-curable compositions, such as varnishes and printing inks.Type: GrantFiled: September 24, 2002Date of Patent: January 23, 2007Assignee: Sun Chemical CorporationInventors: Shaun Lawrence Herlihy, Roger Edward Burrows, Robert Stephen Davidson
-
Patent number: 7125442Abstract: A lightfast additive and an ink composition including the same include a benzophenone moiety for lightfastness and a moiety for wettability and the ability to stabilize a colorant, wherein the two moieties are covalently bonded. The lightfast additive may exhibit effective ultraviolet (UV) light absorption capacity, effective wettability, and an ability to stabilize a colorant. The ink composition utilizing the light fast additive thus has an improved lightfastness and long-term storage stability.Type: GrantFiled: May 24, 2004Date of Patent: October 24, 2006Assignee: Samsung Electronics Co., Ltd.Inventors: Kyung-hoon Lee, Seung-min Ryu, Yeon-kyoung Jung
-
Patent number: 6930197Abstract: This invention relates to a process for the preparation of compounds of the formula: wherein R1 is C1-C6alkyl and the C1-C6alkyl moiety is straight or branched.Type: GrantFiled: March 22, 2002Date of Patent: August 16, 2005Assignee: Aventis Pharmaceuticals Inc.Inventor: Timothy A. Ayers
-
Patent number: 6903232Abstract: This invention relates to a novel process to obtain highly pure 4-(cyclopropylcarbonyl)-?,?-dimethylphenylacetic acid of Formula I through crystallization from a mixture of para and meta regioisomers of Formula I and II in cyclohexane, whereby the amount of undesired meta isomer, 3-(cyclopropylcarbonyl)-?,?-dimethylphenylacetic acid of Formula II is decreased to below 0.5%. The compound of Formula I is a key intermediate for the preparation of high purity terfenadine carboxylate, which is a known antihistaminic.Type: GrantFiled: July 2, 2003Date of Patent: June 7, 2005Assignee: Aurobindo Pharma Ltd.Inventors: Ramesh Dandala, Umashankar Das, Divvela Venkata Naga Srinivasa Rao, Meenakshisunderam Sivakumaran
-
Patent number: 6784292Abstract: The invention relates to a method for the preparation of compound of formula (1). The invention further relates to the previously unknown compounds of formulas (5 and 6) as intermediates in the production of benzodiazepines of formula (1).Type: GrantFiled: August 21, 2003Date of Patent: August 31, 2004Assignee: Schering AGInventors: Eric Winter, Matthias Schneider, Ulf Tilstam
-
Publication number: 20040132812Abstract: The invention relates to new antibiotics designated Cyan-416A, Cyan 416B, Cyan-416C, Cyan-416D and Cyan-416E to their production by fermentation of Acremonium sp. NRRL 30631 to methods for recovery and concentration from the crude solutions, and to a process for purification and to semisynthetic ethers of Cyan-416B.Type: ApplicationFiled: December 15, 2003Publication date: July 8, 2004Applicant: Wyeth Holdings CorporationInventors: Haiyin He, Ramunas Bigelis
-
Patent number: 6677473Abstract: Compounds and pharmaceutical compositions useful as plasminogen activator inhibitor (PAI) antagonists are provided. In particular, methods of antagonizing PAI with substituted and unsubstituted aryl and heteroaryl ethers and thioethers, benzils, benzyl ethers, benzoate esters, sulfones and benzophenones are provided.Type: GrantFiled: November 17, 2000Date of Patent: January 13, 2004Assignee: Corvas International INCInventors: Edwin L. Madison, Terence K. Brunck, Joseph Edward Semple, Marguerita Lim-Wilby, Kent E. Pryor, Ronald D. Lewis, II, David F. Duncan, C. Maxwell Lawrence
-
Publication number: 20020111513Abstract: This invention relates to a process for the preparation of compounds of the formula: 1Type: ApplicationFiled: March 22, 2002Publication date: August 15, 2002Inventor: Timothy A. Ayers