Oxy In Acid Moiety Patents (Class 560/53)
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Patent number: 4091111Abstract: A novel substituted-arylacetic acid ester of the formula, ##STR1## wherein R.sub.1 and R.sub.2 are each hydrogen or a halogen atom, a C.sub.1 -C.sub.4 alkyl, C.sub.2 -C.sub.4 alkenyl, C.sub.1 -C.sub.4 alkoxy, cyano, nitro, methylthio, C.sub.1 -C.sub.4 alkanoyl, C.sub.1 -C.sub.4 alkanoyloxy, or C.sub.1 -C.sub.4 alkoxycarbonyl group, or R.sub.1 and R.sub.2, taken together, may form methylenedioxy, a C.sub.3 -C.sub.5 alkylene or butadienylene (--CH.dbd.CH--CH.dbd.CH--) ring; R.sub.3 is a C.sub.2 -C.sub.4 alkyl, C.sub.2 -C.sub.4 alkenyl, propargyl, C.sub.3 -C.sub.6 cycloalkyl or cyclopropylmethyl group; R.sub.4 is hydrogen or a halogen atom, methyl or ethyl group; R.sub.5 is allyl, propargyl, 3-butenyl, 3-butynyl, phenyl or benzyl group; and A is oxygen or sulfur atom or --CH.dbd.CH-- group, which possesses various useful insecticidal and acaricidal activities and can be prepared by reacting a substituted-arylacetic acid of the formula; ##STR2## wherein R.sub.1, R.sub.2, R.sub.Type: GrantFiled: October 1, 1976Date of Patent: May 23, 1978Assignee: Sumitomo Chemical Company LimitedInventors: Nobuo Ohno, Isao Ohno, Toshio Nishioka, Hisami Takeda, Kiyoshi Kasamatsu
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Patent number: 4090027Abstract: Isoindole derivatives of the formula ##STR1## wherein R.sub.1 -R.sub.6, A and Z are as hereinafter described. The isoindole derivatives are useful as appetite suppressants.Type: GrantFiled: August 25, 1976Date of Patent: May 16, 1978Assignee: Hoffmann-La Roche Inc.Inventor: Roland Jaunin
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Patent number: 4087615Abstract: Prostaglandin analogs with the following cyclopentane ring structure: ##STR1## are disclosed along with intermediates useful in their preparation and processes for their preparation. These analogs are useful for the same pharmacological purposes as the prostaglandins, particularly and especially as blood platelet aggregation inhibitors.Type: GrantFiled: December 30, 1976Date of Patent: May 2, 1978Assignee: The Upjohn CompanyInventor: Douglas Ross Morton, Jr.
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Patent number: 4087620Abstract: The present invention relates to 15-cycloalkyl-prostaglandins of the formula: ##STR1## WHEREIN A represents a grouping of the formula: ##STR2## W represents ethylene or trans-vinylene, X represents ethylene or cis-vinylene, Y represents ethylene or trans-vinylene, R represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 12 carbon atoms, R.sup.1 represents a hydrogen atom or a methyl or ethyl group, R.sup.2 represents a straight- or branched-chain alkyl group containing from 2 to 8 carbon atoms or a phenyl group unsubstituted or substituted by an alkyl group containing from 1 to 3 carbon atoms, R.sup.3 represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 3 carbon atoms, and n represents 4 or 5) and cyclodextrin clathrates of such acids and esters and, when R represents a hydrogen atom, non-toxic salts thereof.These new compounds exhibit characteristic prostaglandin-like activities.Type: GrantFiled: July 7, 1976Date of Patent: May 2, 1978Assignee: Ono Pharmaceutical CompanyInventors: Masaki Hayashi, Seiji Kori, Isao Ohyama, Sadahiko Iguchi, Takanori Okada
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Patent number: 4087616Abstract: Prostaglandin-type compounds with a phenoxy or substituted-phenoxy substituent at the C-16 position are disclosed, with processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.Type: GrantFiled: February 7, 1977Date of Patent: May 2, 1978Assignee: The Upjohn CompanyInventor: Norman A. Nelson
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Patent number: 4087618Abstract: This invention comprises certain analogs of the prostaglandins in which the double bond between C-13 and C-14 is replaced by a triple bond. Also provided in this invention, are novel chemical processes and novel chemical intermediates useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.Type: GrantFiled: March 7, 1977Date of Patent: May 2, 1978Assignee: The Upjohn CompanyInventor: Herman W. Smith
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Patent number: 4083990Abstract: The present invention relates to novel not naturally occurring 10,11-dihydro-derivatives of prostaglandins of the A-series as well as a process for their preparation. The compounds of the invention have an antiprostaglandin effect and may be used as medicaments for the inhibition or suppression of pharmacological properties of the prostaglandins.Type: GrantFiled: June 23, 1976Date of Patent: April 11, 1978Assignee: Hoechst AktiengesellschaftInventors: Milos Babej, Wilhelm Bartmann, Gerhard Beck, Ulrich Lerch
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Patent number: 4081554Abstract: 1-Oxo-2,2-disubstituted-5-indanyloxy(or thio)alkanoic acids and their salt, ester, anhydride, amide and 5-tetrazolyl derivatives are disclosed. The products display a dual pharmaceutical utility in that they exhibit diuretic, saluretic and uricosuric activity. The acid products are prepared by treating a 2,2-disubstituted-5-hydroxy(or mercapto)-1-indanone with an haloalkanoic acid or ester thereof and, if the ester is employed, hydrolyzing the ester.Type: GrantFiled: July 13, 1976Date of Patent: March 28, 1978Assignee: Merck & Co., Inc.Inventors: Edward J. Cragoe, Jr., Otto W. Woltersdorf, Jr.
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Patent number: 4080505Abstract: .alpha.-CHLOROCARBOXYLIC ACIDS OF THE FORMULA ##STR1## wherein Y stands for a lower alkyl group having 1 to 6 carbon atoms or a phenyl group, a benzoyl group or a phenylalkyl group having 7 to 11 carbon atoms, which may have a lower alkyl group having 1 to 3 carbon atoms, a lower alkoxy group having 1 to 3 carbon atoms or a halogen on the phenyl rings as a substituent; R.sup.1 stands for a lower alkylene group having 1 to 4 carbon atoms or a valency bond; L stands for a lower alkyl group having 1 to 3 carbon atoms; and Z stands for a carboxyl group or a group convertible to carboxyl group, are useful as, for example, remedies for hyperlipemia, diabetes and so on of mammals including human beings.Type: GrantFiled: June 3, 1976Date of Patent: March 21, 1978Assignee: Takeda Chemical IndustriesInventors: Yutaka Kawamatsu, Takahiro Saraie, Eiko Imamiya, Yukihiko Hamuro
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Patent number: 4079055Abstract: The disclosure relates to a novel chemical process whereby enone intermediates for prostaglandins are reduced steroselectively to the .alpha.-enols, the .alpha.-hydroxy of which corresponds to the prostaglandin 15.alpha.-hydroxy group.Type: GrantFiled: May 21, 1976Date of Patent: March 14, 1978Assignee: Imperial Chemical Industries LimitedInventors: Keith Blakeney Mallion, Graham Ernest Robinson
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Patent number: 4078081Abstract: The present invention relates to new cyclopentane derivatives having the formula ##STR1## and to a process for their manufacture. The compounds can be used as medicaments due to their antiprostaglandin effect.Type: GrantFiled: June 2, 1975Date of Patent: March 7, 1978Assignee: Hoechst AktiengesellschaftInventors: Ulrich Lerch, Milos Babej, Wilhelm Bartmann, Rudolf Kunstmann
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Patent number: 4073934Abstract: Optically active and racemic prostaglandin derivatives of the formula ##STR1## wherein R.sub.1 is --OR.sub.5 ; --NHSO.sub.2 CH.sub.3 ; or --O--CH.sub.2 --U--V; R.sub.5 is hydrogen, alkyl, aryl, or a heterocyclic group; U is a direct bond, carbonyl or carbonyloxy; and V is phenyl substituted by 1-3 phenyl, alkoxy of 1-2 carbon atoms, or halogen, preferably bromine;R.sub.2 is hydrogen or alkyl of 1-5 carbon atoms;R.sub.3 is alkyl, substituted or unsubstituted cycloalkyl, straight-chain or branched alkyl of 1-5 carbon atoms substituted by aryl or substituted aryl, when R.sub.1 is as above; or R.sub.3 is aryl or substituted aryl group when R.sub.1 is --OR.sub.5 ', --NHSO.sub.2 CH.sub.3, or --O--CH.sub.2 --U--V and R.sub.5 ' is aryl or a heterocyclic group and U and V are as above;R.sub.4 is hydrogen or an ether or acyl residue;A is --CH.sub.2 --CH.sub.2 -- or cis--CH.dbd.CH--;B is --CH.sub.2 --CH.sub.2 -- or trans--CH.dbd.CH--;D is a direct bond, oxygen, or sulfur;Z is carbonyl or >CH OR.sub.4 wherein OR.sub.Type: GrantFiled: April 16, 1976Date of Patent: February 14, 1978Assignee: Schering AktiengesellschaftInventors: Werner Skuballa, Bernd Raduechel, Helmut Vorbrueggen, Walter Elger, Olaf Loge, Eckehard Schillinger
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Patent number: 4070538Abstract: Prostaglandin analogs with the following cyclopentane ring structure: ##STR1## are disclosed along with intermediates useful in their preparation and processes for their preparation. These analogs are useful for the same pharmacological purposes as the prostaglandins, particularly and especially as blood platelet aggregation inhibitors.Type: GrantFiled: December 30, 1976Date of Patent: January 24, 1978Assignee: The Upjohn CompanyInventor: Douglas Ross Morton, Jr.
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Patent number: 4069389Abstract: Prostaglandin analogs with the following cyclopentane ring structure: ##STR1## are disclosed along with intermediates useful in their preparation and processes for their preparation. These analogs are useful for the same pharmacological purposes as the prostaglandins, particularly and especially as blood platelet aggregation inhibitors.Type: GrantFiled: December 30, 1976Date of Patent: January 17, 1978Assignee: The Upjohn CompanyInventor: Douglas Ross Morton, Jr.
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Patent number: 4069241Abstract: Tricyclic aromatic compounds of the formula ##STR1## including those wherein: A. R.sub.1 is H, R.sub.2 is carbomethoxy, and R.sub.3 is methyl;B. R.sub.1 is acetyl, R.sub.2 is carbomethoxy, and R.sub.3 is methyl;C. R.sub.1 and R.sub.3 are methyl and R.sub.2 is carbomethoxy;D. R.sub.1, R.sub.2, and R.sub.3 are hydrogen; andE. R.sub.1 and R.sub.3 are methyl and R.sub.2 is hydrogenAre intermediates for the total synthesis of steroids.Type: GrantFiled: May 26, 1976Date of Patent: January 17, 1978Assignee: The United States of America as represented by the Department of Health, Education and WelfareInventors: Ulrich Weiss, Kenner C. Rice
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Patent number: 4069390Abstract: Prostaglandin analogs with the following cyclopentane ring structure: ##STR1## are disclosed along with intermediates useful in their preparation and processes for their preparation. These analogs are useful for the same pharmacological purposes as the prostaglandins, particularly and especially as blood platelet aggregation inhibitors.Type: GrantFiled: December 30, 1976Date of Patent: January 17, 1978Assignee: The Upjohn CompanyInventor: Douglas Ross Morton, Jr.
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Patent number: 4068075Abstract: There is described the stereoselective total synthesis of novel .DELTA..sup.2,3 -1,4-morpholine-2-carboxylic acids possessing a fused .beta.-lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system represented by the general formula ##STR1## wherein Z is halo, hydroxyl, etherified hydroxyl or hydroxyl esterified with a carboxylic acid residue or a sulfonic acid residue and X is amino, azido or acylamino. Also included in the invention are compounds of formula I in which the carboxyl group at the 2-position is protected as by an easily cleavable ester group and salts of both the free acids and carboxyl-protected compounds of formula I. The compounds of formula I are potent antibacterial agents or are of use as intermediates in the preparation of such antibacterial agents.Type: GrantFiled: August 19, 1976Date of Patent: January 10, 1978Assignee: Bristol-Myers CompanyInventors: Marcel Menard, Gary M. F. Lim, Terry T. Conway
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Patent number: 4066836Abstract: Prostaglandin analogs with the following cyclopentane ring structure: ##STR1## are disclosed along with intermediates useful in their preparation and processes for their preparation. These analogs are useful for the same pharmacological purposes as the prostaglandins, particularly and especially as blood platelet aggregation inhibitors.Type: GrantFiled: December 30, 1976Date of Patent: January 3, 1978Assignee: The Upjohn CompanyInventor: Douglas Ross Morton, Jr.
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Patent number: 4066784Abstract: Tropone derivatives substituted with an amino-derivative of oxalic acid or acetic acid are disclosed. In addition, the tropone nucleus can be optionally further substituted. The foregoing compounds are useful for preventing or treating allergic conditions in a mammal. Methods for the preparation and use of the compounds are disclosed.Type: GrantFiled: June 17, 1976Date of Patent: January 3, 1978Assignee: Ayerst, McKenna and Harrison Ltd.Inventors: Jehan F. Bagli, Tibor Bogri
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Patent number: 4065628Abstract: The disclosure includes novel compounds which differ from the known prostaglandins PGF.sub.2.alpha., PGF.sub.2.beta., PGE.sub.2, PGA.sub.2, and PGB.sub.2 in that the carbon-carbon double bond in the carboxyl-terminated chain of the novel compounds is in the 4,5-position rather than in the 5,6-position, and in that there is a phenyl or substituted phenyl group in the other chain of the novel compounds. These novel compounds are useful for a variety of pharmacological purposes, including abortion, labor induction, and reduction of gastric secretion.Type: GrantFiled: November 12, 1976Date of Patent: December 27, 1977Assignee: The Upjohn CompanyInventor: Barney J. Magerlein
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Patent number: 4064160Abstract: 2,2-Difluoro prostaglandin E, F.sub..alpha., F.sub..beta., A, and B analog are disclosed with intermediates and with processes for making them. These compounds differ from the prostaglandins in that they have two fluoro atoms at the C-2 position in place of the two hydrogen atoms at C-2 in the prostaglandins. These compounds are useful for a variety of pharmacological purposes, including antiulcer, inhibition of platelet aggregation, increase in nasal patency, labor induction at term, and wound healing.Type: GrantFiled: September 17, 1976Date of Patent: December 20, 1977Assignee: The Upjohn CompanyInventor: Udo F. Axen
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Patent number: 4061766Abstract: The present invention relates to cyclopentane derivatives similar to prostaglandins. Due to their antiprostaglandin effect they have valuable properties as medicaments.Type: GrantFiled: October 28, 1976Date of Patent: December 6, 1977Assignee: Hoechst AktiengesellschaftInventors: Wilhelm Bartmann, Rudolf Kunstmann, Ulrich Lerch, Bernward Scholkens
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Patent number: 4061666Abstract: This invention comprises certain analogs of the prostaglandins in which there is a triple bond between C-5 and C-6 or C-4 and C-5. Also provided in this invention, are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.Type: GrantFiled: November 4, 1976Date of Patent: December 6, 1977Assignee: The Upjohn CompanyInventor: Chiu-Hong Lin
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Patent number: 4059614Abstract: 2,2-Difluoro prostaglandin E, F.sub..alpha., F.sub..beta., A, and B analogs are disclosed with intermediates and with processes for making them. These compounds differ from the prostaglandins in that they have two fluoro atoms at the C-2 position in place of the two hydrogen atoms at C-2 in the prostaglandins. These compounds are useful for a variety of pharmacological purposes, including antiulcer, inhibition of platelet aggregation, increase in nasal patency, labor induction at term, and wound healing.Type: GrantFiled: September 17, 1976Date of Patent: November 22, 1977Assignee: The Upjohn CompanyInventor: Udo F. Axen
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Patent number: 4059576Abstract: 11-Substituted prostaglandins E.sub.1, E.sub.2 and F.sub.2.alpha. useful as cardiovascular agents and as agents for inducing labor in pregnant females and for the termination of pregnancy and a process for preparing these prostaglandins.Type: GrantFiled: September 17, 1975Date of Patent: November 22, 1977Assignee: Hoffmann-La Roche, Inc.Inventors: George William Holland, Jane Liu Jernow, Perry Rosen
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Patent number: 4058558Abstract: This invention relates to new chemical compounds useful as drugs, as well as to pharmaceutical compositions containing the same.The new products are aromatic keto acid compounds with antiinflammatory as well as analgetic and hypocholesteremic activity and having the general formula ##STR1## wherein R.sub.1 is hydrogen, halogen, phenyl, halophenyl, phenoxy, or substituted phenoxy.R.sub.2 is hydrogen or alkoxy.R.sub.1 and R.sub.2 may form a ring, for instance: phenyl or cyclohexyl.R.sub.3 is always other than hydrogen, being either methyl (CH.sub.3) or methylene. When R.sub.3 is CH.sub.3, a double bond is present between the A and B carbons. When R.sub.3 is a methylene connected by a double bond to the B carbon, there can be only a single bond between the A and B carbons. The remaining valences of the A carbon atom are satisfied by hydrogen atoms.R.sub.Type: GrantFiled: March 21, 1975Date of Patent: November 15, 1977Assignee: Pierre Fabre S.A.Inventors: Henri Cousse, Gilbert Mouzin, Jean-Pierre Rieu
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Patent number: 4057641Abstract: There are described compounds of formula I, ##STR1## in which Ra is hydrogen, alkyl, alkenyl or phenyl,R.sub.3, r.sub.5, r.sub.7 and R.sub.8, which may be the same or different, are each hydrogen, alkyl, alkoxy, halogen, hydroxy, alkenyl or phenyl,Rx is hydrogen or alkyl,Ry and Rz are both hydrogen, or together represent a carbonyl oxygen atom,Rb and Rc are both hydrogen or together represent a carbon-carbon bond,And pharmaceutically acceptable derivatives thereof. There are also described processes for making the compounds and pharmaceutical, e.g. anti-inflammatory compositions, containing the compounds.Type: GrantFiled: March 12, 1975Date of Patent: November 8, 1977Assignee: Fisons LimitedInventors: Richard Anthony Appleton, Kevin Brown
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Patent number: 4057572Abstract: This invention comprises certain analogs of the prostaglandins in which there is a triple bond between C-5 and C-6 or C-4 and C-5. Also provided in this invention, are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.Type: GrantFiled: November 4, 1976Date of Patent: November 8, 1977Assignee: The Upjohn CompanyInventor: Chiu-Hong Lin
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Patent number: 4057574Abstract: 2,2-Difluoro prostaglandin E, F.sub..alpha., F.sub..beta., A and B analog are disclosed with intermediates and with processes for making them. These compounds differ from the prostaglandins in that they have two fluoro atoms at the C-2 position in place of the two hydrogen atoms at C-2 in the prostaglandins. These compounds are useful for a variety of pharmacological purposes, including antiulcer, inhibition of platelet aggregation, increase in nasal patency, labor induction at term, and wound healing.Type: GrantFiled: September 17, 1976Date of Patent: November 8, 1977Assignee: The Upjohn CompanyInventor: Udo F. Axen
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Patent number: 4057571Abstract: This disclosure describes 11-deoxy-11-substituted members of the E.sub.2, F.sub.2, E.sub.1, F.sub.1, dihydro E.sub.1 and dihydro F.sub.1 prostaglandin series which are useful as hypotensive agents and as anti-ulcer agents.Type: GrantFiled: February 24, 1975Date of Patent: November 8, 1977Assignee: American Cyanamid CompanyInventors: Charles Vincent Grudzinskas, Martin Joseph Weiss
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Patent number: 4056556Abstract: 2,2-Difluoro prostaglandin E, F.sub..alpha., F.sub..beta., A, and B analog are disclosed with intermediates and with processes for making them. These compounds differ from the prostaglandins in that they have two fluoro atoms at the C-2 position in place of the two hydrogen atoms at C-2 in the prostaglandins. These compounds are useful for a variety of pharmacological purposes, including antiulcer, inhibition of platelet aggregation, increase in nasal patency, labor induction at term, and wound healing.Type: GrantFiled: September 17, 1976Date of Patent: November 1, 1977Assignee: The Upjohn CompanyInventor: Udo F. Axen
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Patent number: 4056555Abstract: 2,2-Difluoro prostaglandin E, F.sub..alpha., F.sub..beta., A, and B analogs are disclosed with intermediates and with processes for making them. These compounds differ from the prostaglandins in that they have two fluoro atoms at the C-2 position in place of the two hydrogen atoms at C-2 in the prostaglandins. These compounds are useful for a variety of pharmacological purposes, including antiulcer, inhibition of platelet aggregation, increase in nasal patency, labor induction at term, and wound healing.Type: GrantFiled: September 17, 1976Date of Patent: November 1, 1977Assignee: The Upjohn CompanyInventor: Udo F. Axen
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Patent number: 4055602Abstract: This invention comprises certain analogs of the prostaglandins in which the C-1 carboxyl is replaced by a primary alcohol. Also provided in this invention, are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.Type: GrantFiled: January 8, 1976Date of Patent: October 25, 1977Assignee: The Upjohn CompanyInventor: Norman A. Nelson
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Patent number: 4053485Abstract: Process for preparing bicyclic diols of the formula ##STR1## wherein C.sub.p H.sub.2p is a valence bond or alkylene of one to 4 carbon atoms, inclusive, with one or 2 carbon atoms in the chain between the phenylene ring and --O--; wherein Y is a hydrocarbyl or substituted hydrocarbly group; and wherein indicates attachment to the cyclopropane ring in exo or endo configuration. These diols and the intermediates prepared herein are useful intermediates in preparing prostaglandin analogs having pharmacological utility.Type: GrantFiled: July 26, 1976Date of Patent: October 11, 1977Assignee: The Upjohn CompanyInventor: Douglas R. Morton, Jr.
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Patent number: 4053601Abstract: The compounds are 3-((3-substituted amino-2-hydroxypropoxy)-phenyl)-6-hydrazino pyridazines which have .beta.-adrenergic blocking and vasodilator activity.Type: GrantFiled: June 3, 1975Date of Patent: October 11, 1977Assignee: Smith Kline & French Laboratories LimitedInventors: William John Coates, Anthony Maitland Roe, Robert Antony Slater, Edwin Michael Taylor
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Patent number: 4053502Abstract: This invention comprises certain analogs of the prostaglandins in which there is a triple bond between C-5 and C-6 or C-4 and C-5. Also provided in this invention, are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.Type: GrantFiled: November 4, 1976Date of Patent: October 11, 1977Assignee: The Upjohn CompanyInventor: Chiu-Hong Lin
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Patent number: 4052446Abstract: 11-Substituted prostaglandins E.sub.1, E.sub.2 and F.sub.2.alpha. useful as cardiovascular agents and as agents for inducing labor in pregnant females and for the termination of pregnancy and a process for preparing these prostaglandins.Type: GrantFiled: June 18, 1974Date of Patent: October 4, 1977Assignee: Hoffmann-La Roche Inc.Inventors: George William Holland, Jane Liu Jernow, Perry Rosen
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Patent number: 4052395Abstract: Agricultural fungicidal compositions containing as an active ingredient one or more of 6-(substitutedphenyl)-3(2H)-pyridazinone compounds, salts thereof and 6-(substituted-phenyl)-4,5-dihydro-3(2H)-pyridazinone compounds, as well as new pyridazinone compounds having fungicidal activities.Type: GrantFiled: August 30, 1976Date of Patent: October 4, 1977Assignee: Sankyo Company LimitedInventors: Teruomi Jojima, Yukiyoshi Takahi
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Patent number: RE29608Abstract: The invention provides novel 5- and 6-benzoxazolyl alkanoic acids, optionally substituted in the 2-position, and derivatives thereof which possess anti-inflammatory, anti-pyretic and analgesic activity. Also provided is a process for preparing such compounds by cyclizing an appropriately substituted o-aminophenol and, if necessary, converting the resultant benzoxazole to the desired compound.Type: GrantFiled: February 1, 1977Date of Patent: April 11, 1978Assignee: Lilly Industries LimitedInventors: Delme Evans, David William Dunwell, Terence Alan Hicks