Polycarboxylic Acid Patents (Class 560/54)
  • Patent number: 8920830
    Abstract: The present invention relates to wound dressings having a wound contacting layer that contains a wound healing composition and which is adapted to maintain a temperature different from ambient, for example achieve and maintain a heat-absorbing effect on the underlying tissues. The specific physico-chemical structure of the devices of the invention allows fluid containment and absorption of wound secretions while avoiding skin macerations.
    Type: Grant
    Filed: July 7, 2009
    Date of Patent: December 30, 2014
    Assignee: Laboratoire Medidom S.A.
    Inventor: Burkhard Mathies
  • Patent number: 8692013
    Abstract: A process for making bis(aryloxyalkyl)terephthalates useful as antiplasticizers for thermoplastic polyesters is disclosed. Dimethyl terephthalate is reacted with an excess of an aryloxyalkanol in the presence of a condensation catalyst to produce an intermediate mixture comprising a bis(aryloxyalkyl)terephthalate, a mono(aryloxyalkyl)terephthalate, and unreacted aryloxyalkanol. This mixture continues to react at reduced pressure while unreacted aryloxyalkanol is removed and the mono-ester content is reduced to less than 1 mole % based on the combined amounts of mono- and bis-esters. Both steps are performed substantially in the absence of oxygen. Additional unreacted aryloxyalkanol is then removed to provide a purified bis(aryloxyalkyl)terephthalate having an overall purity of at least 98 mole % and a yellowness index less than 10.
    Type: Grant
    Filed: November 25, 2012
    Date of Patent: April 8, 2014
    Assignee: Stepan Company
    Inventors: Rick Tabor, Brian K. Mirous, Timothy L. Lambert, Michael E. O'Brien, Matthew I. Levinson, Daniel J. Dershowitz
  • Publication number: 20130315841
    Abstract: Methods for the synthesis and use of functionalized, substituted naphthalenes are described. The functionalized, substituted naphthalenes display useful properties including liquid crystals and fluorescence properties, such as solvatochromatic fluorescence, with high quantum yields, Stoke's shift, and show emission maxima that are significantly red-shifted.
    Type: Application
    Filed: March 15, 2013
    Publication date: November 28, 2013
    Inventor: Kay M. Brummond
  • Publication number: 20130079544
    Abstract: The use of compounds in the treatment of skin disorders is described. In particular, compounds having the general formula (I): are described. A process for preparing such compounds and their cosmetic or dermatological use are also described. The described compounds can act as bactericides. As a result, they can be useful in the treatment of conditions associated with the presence of bacteria, more specifically of P. acnes.
    Type: Application
    Filed: December 22, 2010
    Publication date: March 28, 2013
    Applicant: GALDERMA RESEARCH & DEVELOPMENT
    Inventors: Nicolas Rodeville, Jean-Claude Pascal, Claire Bouix-Peter
  • Patent number: 8344172
    Abstract: A process for making bis(aryloxyalkyl)terephthalates useful as antiplasticizers for thermoplastic polyesters is disclosed. Dimethyl terephthalate is reacted with an excess of an aryloxyalkanol in the presence of a condensation catalyst to produce an intermediate mixture comprising a bis(aryloxyalkyl)terephthalate, a mono(aryloxyalkyl)terephthalate, and unreacted aryloxyalkanol. This mixture continues to react at reduced pressure while unreacted aryloxyalkanol is removed and the mono-ester content is reduced to less than 1 mole % based on the combined amounts of mono- and bis-esters. Both steps are performed substantially in the absence of oxygen. Additional unreacted aryloxyalkanol is then removed to provide a purified bis(aryloxyalkyl)terephthalate having an overall purity of at least 98 mole % and a yellowness index less than 10.
    Type: Grant
    Filed: March 25, 2011
    Date of Patent: January 1, 2013
    Assignee: Stepan Company
    Inventors: Rick Tabor, Brian K. Mirous, Timothy L. Lambert, Michael E. O'Brien, Matthew I. Levinson, Daniel J. Dershowitz
  • Publication number: 20120323035
    Abstract: Compounds of the following general formula (I): are described. Also described, are processes of their preparation and their use in therapeutic applications.
    Type: Application
    Filed: December 10, 2010
    Publication date: December 20, 2012
    Applicant: GALDERMA RESEARCH & DEVELOPMENT
    Inventors: Claire Bouix-Peter, Jean-Claude Pascal, Nicolas Rodeville
  • Patent number: 8304513
    Abstract: Disclosed are polyesters, particularly poly(trimethylene terephthalate), comprising fluorovinylether functionalized aromatic repeat units, and methods to make the polyester polymers. The polymers are useful for imparting soil resistance to polyesters, particularly in the form of fibers, fabrics, and carpets.
    Type: Grant
    Filed: September 1, 2010
    Date of Patent: November 6, 2012
    Assignee: E I du Pont de Nemours and Company
    Inventors: Neville Everton Drysdale, Surbhi Mahajan, Kenneth Gene Moloy, Fredrik Nederberg, Joel M. Pollino, Joachim C. Ritter
  • Publication number: 20120264925
    Abstract: A process for preparing pyrazole-glycoside derivatives of the general Formula (I) in which the meanings are R1 H and R2 F; or R1 F and R2 H; or R1 F and R2 F; R3 (C1-C8)-alkyl, where one, more than one or all hydrogen(s) may be replaced by fluorine; X (C1-C3)-alkylene, (C2-C3)-alkenylene.
    Type: Application
    Filed: August 26, 2010
    Publication date: October 18, 2012
    Applicant: SANOFI
    Inventors: Michael Podeschwa, David Rigal, Kai Rossen, Bernhard Otto, Hermut Wehlan, Theodor Andreas Wollmann, Bernd Becker, Berndt Kulitzscher, Alexander Schaefer
  • Patent number: 8288580
    Abstract: A benzophenone compound is represented by the following formula (I): (A)n-X—(B)m??(I) wherein X is an organic moiety having (n+m) valence, (n+m) being an integer ranging from 1 to 4; A is B is R is H or a methyl group; n is the number of A bonded to X and is an integer ranging from 1 to 4; and m is the number of B bonded to X and is an integer ranging from 0 to 3.
    Type: Grant
    Filed: November 9, 2010
    Date of Patent: October 16, 2012
    Assignee: Double Bond Chemical Ind. Co., Ltd.
    Inventors: Jimmy Liu, Kuei-Ta Chen, I-Ling Chen
  • Publication number: 20110054190
    Abstract: Disclosed is a technology for enabling an efficient asymmetric Michael addition reaction which does not require a large amount of a malonic ester, while having a short reaction time. Specifically disclosed is a catalyst which is composed of MX2 (wherein M is Be, Mg, Ca, Sr, Ba or Ra and X is an arbitrary group) and a compound represented by general formula [I]. [In the formula, R7, R8, R9 and R10 each represents a substituted cyclic group or an unsubstituted cyclic group.
    Type: Application
    Filed: January 28, 2009
    Publication date: March 3, 2011
    Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY
    Inventors: Shu Kobayashi, Magno Agostinho, Uwe Schneider, Miyuki Yamaguchi
  • Publication number: 20110020749
    Abstract: The object of the present invention is to provide a chemically amplified resist composition excellent in a resolution and a mask error enhancement factor. By employing the salt represented by the formulae (A1) as an acid generator of a resist composition, the above mentioned object is achieved. wherein Z+ represents an organic cation, Q1 and Q2 each independently represent a fluorine atom or a perfluoroalkyl group, Ra2 represents a divalent alicyclic hydrocarbon group pr the like, Ra2 represents an elimination group represented by the formulae (II-1) or (II-2). In the formulae (II-1) or (II-2), Ra3 and Ra4 each independently represent a hydrogen atom or an aliphatic hydrocarbon group, Ra5 represents an aliphatic hydrocarbon group, Ra6 represents a divalent aliphatic hydrocarbon group, and Ra7 represents an aliphatic hydrocarbon group.
    Type: Application
    Filed: July 27, 2010
    Publication date: January 27, 2011
    Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Koji Ichikawa, Isao Yoshida, Satoshi Yamaguchi
  • Publication number: 20100207078
    Abstract: The present invention provides novel compositions suitable for use in an intermolecular photodeprotection reaction scheme. Such compositions include a chromophore compound and a second compound having a photocleavable group bonded to a protected functional group. Novel compounds which can used in intramolecular photodeprotection are also provided. These compounds have a chromophore moiety bonded to a photocleavable group, which itself is bonded to a protected group. The compounds and compositions disclosed herein can be used in two-photon and multi-photon excitation.
    Type: Application
    Filed: July 12, 2007
    Publication date: August 19, 2010
    Inventors: Seth Marder, Stephen Barlow, Joseph Perry, Jing Wang
  • Patent number: 7763650
    Abstract: A new pharmaceutical compound for treating central nervous disorders, the compound comprising a therapeutically effective amount of valproic acid or pharmaceutically acceptable derivative thereof covalently bonded to myo-inositol. The invention also provides a composition, method for treating a patient and a method for obtaining the compound.
    Type: Grant
    Filed: March 15, 2006
    Date of Patent: July 27, 2010
    Assignees: Medipharma S.A., University Nacional De La Plata
    Inventors: Luis Bruno-Blanch, Sung Chin Moon
  • Publication number: 20100104979
    Abstract: Compounds of the Formula (I) wherein x is an integer from 1-4; p is an integer from 1-3; q is an integer from 0-3; Ar is phenyl, naphthyl, anthryl or phenanthryl each of which optionally is substituted by one or more Cl, CN, OR5, C3-C5alkenyl or C1-C6alkyl which optionally is substituted by one or more OR6, COOR or halogen; R1 if x is 1, is ORS, O—X+, NR8R9, C1-C20alkyl optionally substituted by one or more COOR10, or is C2-C20alkyl interrupted by one ore more O, or is C2-C5alkenyl or phenyl-C1-C4alkyl; R1 if x is 2, is for example C1-C20alkylene; R1 if x is 3, is for example a tri-valent radical; R1if x is 4, is for example a tetravalent radical; R2and R3are hydrogen or C1-C8alkyl, or R2and R3 together are O, C1-C3alkylene or CH?CH; R4 is C1-C4alkyl; R5, R6, R7, R8, R9 and R10 are for example hydrogen or C1-C4alkyl; and X is a x-valent cationic counter ion; are in particular suitable as photoinitiators for the curing with UV-A light (320-450 nm).
    Type: Application
    Filed: March 25, 2008
    Publication date: April 29, 2010
    Inventors: Kurt Dietliker, Peter Murer, Rinaldo Hüsler, Tunja Jung
  • Publication number: 20090042955
    Abstract: Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
    Type: Application
    Filed: August 8, 2008
    Publication date: February 12, 2009
    Inventors: Kevin R. LYNCH, Timothy L. Macdonald
  • Publication number: 20090017307
    Abstract: The present invention relates to advantageous processes for the manufacture of organic pigments and their precursors. The invention particularly relates to reactions carried out in an “All In One Reactor”® (Draiswerke GmbH, Germany), a kneader like the TurbuKneader® of the same company, a paddle dryer like the Turbudry® of the same company or a related system and thereby submitting the reaction mixtures to enhanced driving power as expressed by a Froude number >1, the reaction mixture being caused to react in high concentrations at elevated temperature.
    Type: Application
    Filed: May 16, 2008
    Publication date: January 15, 2009
    Applicant: MCA TECHNOLOGIES, GMBH
    Inventor: Bansi Lal KAUL
  • Patent number: 7368566
    Abstract: Disclosed is a new process and intermediates for preparing benzazepines of Formula (I): wherein R1 and R2 are as defined herein.
    Type: Grant
    Filed: March 29, 2004
    Date of Patent: May 6, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Jose J. Conde, Lewilynn L. Goldfinger, Michael A. McGuire, Susan C. Shilcrat, Michael D. Wallace, Marvin Sungwhan Yu
  • Patent number: 7339071
    Abstract: The invention provides an aryl ethynyl phthalic acid and derivatives thereof (including fluorine-containing compounds) represented by Formulae 1, 3, 5, 4A and 5A including the structure of Formula 2, and method of producing these compounds, in which an aryl ethynyl phthalic anhydride is formed by subjecting an aryl phthalic acid to ring closing:
    Type: Grant
    Filed: March 25, 2005
    Date of Patent: March 4, 2008
    Assignee: FUJIFILM Corporation
    Inventors: Daisuke Urazoe, Hideto Mori, Katsuyoshi Yamakawa
  • Patent number: 7129367
    Abstract: Palladum-phosphine complexes obtained by reacting a 5 compound of formula (1) below with a palladium compound: F(I) (wherein R1 is a hydrogen atom, an alkyl group, a cycloalkyl group or a phenyl group which may be substituted; R2 and R3 are each, the same or different, an alkyl group, a cycloalkyl group or a phenyl group which may be substituted; R4 and R5 are each, the same or different, a hydrogen atom, an alkyl group, a cycloalkyl group or a phenyl group which may be substituted; R6, R7, R8 and R9 are each, the same or different, an alkyl group, a cycloalkyl group, a phenyl group which may be substituted, an alkoxyl group, a dialkylamino group, a halogen atom, a phenyl group, a benzyl group, a naphthyl group or a halogenated alkyl group; R6 and R7, R8 and R9 may be combined to form, each, a fused ring, a trimethylene group, a tetramethylene group or a 20 methylenedioxy group; p, q, r and s are each an integer of 0 to 5; and p+q, and r+s are each in the range of 0 to 5.
    Type: Grant
    Filed: February 12, 2004
    Date of Patent: October 31, 2006
    Assignee: Takasago International Corporation
    Inventors: Ken Suzuki, Yoji Hori
  • Patent number: 6878845
    Abstract: Oligomers from multifunctional acrylates and organonitro compounds are provided. Films obtained from crosslinked oligomers of the present invention are useful as protective or decorative coatings as well as components in adhesives and composites.
    Type: Grant
    Filed: October 15, 2002
    Date of Patent: April 12, 2005
    Assignee: Ashland Inc.
    Inventors: Matthew S. Sheridan, Laurence G. Dammann, Sridevi Narayan-Sarathy
  • Patent number: 6743941
    Abstract: The present invention relates to processes for preparing certain piperidine derivatives, including fexofenadine (F), the active ingredient in the non-sedating antihistamine sold in the U.S. under the designation “Allegra®”. This invention also relates to novel synthetic intermediates useful in the processes of the present invention.
    Type: Grant
    Filed: June 11, 2002
    Date of Patent: June 1, 2004
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Collin Schroeder, Ryan Huddleston, Richard Charles
  • Patent number: 6569810
    Abstract: The present invention relates to novel bicyclic cyclopentane-1,3-dione derivatives of the formula (I) to a process for their preparation and to their use as pesticides and herbicides.
    Type: Grant
    Filed: September 17, 2002
    Date of Patent: May 27, 2003
    Assignee: Bayer Aktiengesellschaft
    Inventors: Reiner Fischer, Michael Ruther, Alan Graff, Arno Widdig, Jacques Dumas, Christoph Erdelen, Peter Dahmen, Markus Dollinger, Ulrike Wachendorff-Neumann
  • Patent number: 6509374
    Abstract: The present invention relates to compounds of the general formula I. The compounds are useful in the treatment of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR).
    Type: Grant
    Filed: April 13, 2001
    Date of Patent: January 21, 2003
    Assignee: Novo Nordisk A/S
    Inventors: Per Sauerberg, Lone Jeppesen, John Patrick Mogensen, Ingrid Pettersson, Paul Stanley Bury
  • Patent number: 6441218
    Abstract: Adipic acid diester is caused to react with alkoxide M(OR)n, wherein R is an alkyl group and M is an alkali metal or alkaline earth metal, the reaction product is successively subjected either to coupling with halomethylstyrene followed by carbonylation, or to coupling with 2-(halomethylphenyl)propionic acid or its ester followed by decarboxylation and hydrolysis. With this process, it is possible to produce more efficiently a specific 2-substituted propionic acid, loxoprofen.
    Type: Grant
    Filed: January 23, 2001
    Date of Patent: August 27, 2002
    Assignee: Nippon Petrochemicals Company, Limited
    Inventors: Saisuke Watanabe, Kazuharu Suyama
  • Patent number: 6369026
    Abstract: The present invention describes a fragrance delivery system which releases fragrant alcohols upon exposure to light. Said system comprises 2-benzoyl benzoates of general formulae which can comprise various subtituents R1-R5 as defined in the application and a substituted R* which is the organic part of a fragrant alcohol. In a further embodiment, the present invention describes a fragrance delivery system which releases fragrant aldehydes or ketones and/or fragrant compounds containing an olefin function.
    Type: Grant
    Filed: August 10, 2000
    Date of Patent: April 9, 2002
    Assignee: Firmenich SA
    Inventors: Jana Pika, Andreas Herrmann, Christian Vial
  • Publication number: 20020035283
    Abstract: A novel process in which an optically active alcohol compound having a desired absolute configuration and a high optical purity can be obtained by asymmetrically hydrogenating a &bgr;-keto acid compound through a simple operation. An optically active alcohol represented by general formula (III) as defined is obtained by asymmetrically hydrogenating a &bgr;-keto ester compound represented by general formula (I) as defined in the presence of at least one ruthenium complex having as a ligand an optically active tertiary diphosphine compound represented by general formula (II) as defined.
    Type: Application
    Filed: July 23, 2001
    Publication date: March 21, 2002
    Applicant: TAKASAGO INTERNATIONAL CORPORATION
    Inventors: Takao Saito, Tohru Yokozawa, Kazuhiko Matsumura, Noboru Sayo
  • Patent number: 6337034
    Abstract: Liquid crystalline compounds which have a wide temperature range of liquid crystal phase, low viscosity, and improved threshold voltage; liquid crystal compositions; and liquid crystal display devices comprising the composition can be provided; and the liquid crystalline compounds are expressed by the general formula (1) Ra—A1—Z1—A2—Z2—A3—(Z3—A4)m—Rb  (1) wherein Ra represents an alkyl group having 1 to 20 carbon atoms one or more —CH2— in which alkyl group may be replaced by —O— or the like, and one or more hydrogen atoms in which alkyl group may be replaced by a halogen atom; Rb represents Ra, a halogen atom, or cyano group; A1, A2, A3, and A4 independently represent a divalent ring group; Z1, Z2, and Z3 independently represent an alkenylene group having 2 to 4 carbon atoms, —COO—, a covalent bond, or the like provided that at least one of Z1 to Z3 represents an alkenylene group having 2 to 4 carbon atoms, and at
    Type: Grant
    Filed: August 24, 1998
    Date of Patent: January 8, 2002
    Assignee: Chisso Corporation
    Inventors: Tomoyuki Kondo, Shuichi Matsui, Kazutoshi Miyazawa, Yasuko Sekiguchi, Etsuo Nakagawa
  • Patent number: 6335462
    Abstract: The compounds of the formula I X[—Y1—A1—Y2—M—Y3—A2—Z]n  I, wherein the variables are as defined in the specification. The compounds are suitable as alignment layers for liquid-crystalline materials, as photocrosslinkable adhesives, as monomers for the production of liquid-crystalline networks, as base material for the preparation of polymerizable liquid-crystal systems which can be doped by chiral compounds, as polymerizable matrix monomers for polymer-dispersed displays or as base material for polymerizable, liquid-crystalline materials for optical components, such as polarizers, retardation plates or lenses.
    Type: Grant
    Filed: May 27, 1999
    Date of Patent: January 1, 2002
    Assignee: BASF Aktiengesellschaft
    Inventors: Karl-Heinz Etzbach, Karl Siemensmeyer, Peter Schuhmacher
  • Patent number: 6258977
    Abstract: An alkyl 3-oxoalkanoate, a process for preparation and use for the synthesis of fatty hydroxylated amino acids, fatty amino alcohols and ceramides.
    Type: Grant
    Filed: July 6, 1999
    Date of Patent: July 10, 2001
    Assignee: L'Oreal
    Inventors: Michel Philippe, Bernadette Luppi, Didier Semeria, Claude Mahieu
  • Patent number: 6133228
    Abstract: A fragrance delivery system which releases fragrant alcohols upon exposure to light. The system comprises 2-benzoyl benzoates of general formulae ##STR1## which can comprise various subtituents R.sub.1 -R.sub.5 as defined in the application and a substituted R* which is the organic part of a fragrant alcohol.
    Type: Grant
    Filed: May 28, 1998
    Date of Patent: October 17, 2000
    Assignee: Firmenich SA
    Inventors: Jana Pika, Andreas Herrmann, Christian Vial
  • Patent number: 5952386
    Abstract: The present invention provides dihalopropene compounds of the general formula: ##STR1## wherein R.sub.1 is C.sub.1 -C.sub.10 alkyl or the like; L is C(.dbd.O)NH or the like; R.sub.2, R.sub.3 and R.sub.4 are independently halogen or the like; R.sub.5, R.sub.6 and R.sub.7 are independently hydrogen or the like; m is an integer of 0 to 4; n is an integer of 0 to 2; X is chlorine or the like; Y is oxygen or the like; and Z is oxygen or the like, which have excellent insecticidal activity so that they are satisfactorily effective for the control of noxious insects.
    Type: Grant
    Filed: September 24, 1997
    Date of Patent: September 14, 1999
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Sanshiro Matsuo, Taro Hirose, Keiichi Izumi, Masaya Suzuki, Noriyasu Sakamoto, Kazunori Tsushima, Shigeru Saito, Hirotaka Takano
  • Patent number: 5852200
    Abstract: Cross-coupling or addition reactions of organic compounds, including acid halides, allylic halides, and .alpha.,.beta.-unsaturated carbonyl containing compounds, with organozinc compounds may be readily and safely carried out in the presence of cuprous iodide. The use of this catalyst in the coupling reaction provides for the preparation of commercially useful products in the pharmaceutical, agrochemical and other industries.
    Type: Grant
    Filed: August 22, 1996
    Date of Patent: December 22, 1998
    Assignee: Rieke Metals, Inc.
    Inventor: Reuben D. Rieke
  • Patent number: 5739376
    Abstract: Fullerene derivatives, methods of preparing the same and methods of using the same, wherein the fullerene derivatives are of the formula I ##STR1##
    Type: Grant
    Filed: October 20, 1995
    Date of Patent: April 14, 1998
    Assignee: Hoechst Aktiengesellschaft
    Inventor: Carsten Bingel
  • Patent number: 5723648
    Abstract: Novel 4-oxoquinoline-3-carboxylic acid compounds of the formula: ##STR1## wherein R.sup.1 is cyclopropyl which may have 1 to 3 substituents of alkyl and halogen; phenyl which may be substituted by 1 to 3 substituents of alkoxy, halogen and OH; alkyl which may be substituted by halogen, alkanoyloxy or OH; alkenyl; or thienyl, R.sup.2 is 5- to 9-membered saturated or unsaturated heterocyclic ring which may be sustituted, R.sup.3 is alkyl, R is H or alkyl, and X is halogen, and pharmaceutically acceptable salts thereof, said compounds having excellent antimicrobial activity and hence being useful as an antimicrobial agent, and a pharmaceutical composition containing said compound as an active ingredient.
    Type: Grant
    Filed: July 5, 1996
    Date of Patent: March 3, 1998
    Assignee: Otsuka Pharmaceutical Company, Limited
    Inventors: Hiraki Ueda, Hisashi Miyamoto, Hiroshi Yamashita, Hitoshi Tone
  • Patent number: 5672730
    Abstract: The present invention relates to a compound of the formula ##STR1## wherein n is an integer from 1 to 4, R is selected from the group consisting of hydrogen and methyl; wherein when n is 1, R.sup.1 is selected from the group consisting of alkyl radicals having 1 to 18 carbon atoms, aryl radicals having 6 to 12 carbon atoms, aralkyl radicals having 7 to 12 carbon atoms, cycloalkyl radicals having 5 to 12 carbon atoms and radicals of the formula: ##STR2## wherein x is an integer of from 1 to 7; wherein when n is 2, R.sup.1 is selected from the group consisting of alkylene radicals having 2 to 18 carbon atoms, cycloalkylene radicals having 5 to 12 carbon atoms, arylene radicals having 6 to 12 carbon atoms, ##STR3## polyalkyl glycol ether radicals having the following structure ##STR4## wherein x is an integer from 1 to 7.
    Type: Grant
    Filed: September 22, 1995
    Date of Patent: September 30, 1997
    Assignee: The Goodyear Tire & Rubber Company
    Inventor: Kirkwood Storer Cottman
  • Patent number: 5523476
    Abstract: A process for producing tetrafluorophthalic anhydride, which comprises chlorinating tetrachlorophthalic anhydride to obtain 3,3,4,5,6,7-hexachloro-1-[3H]-isobenzofuranone, then fluorinating it to obtain 3,4,5,6-tetrafluorophthaloyldifluoride and/or 3,3,4,5,6,7-hexafluoro-1-[3H]-isobenzofuranone, and further reacting the tetrafluorophthalolyldifluoride and/or the hexafluoro-1-[3H]-isobenzofuranone with an inorganic base or an organic acid to obtain tetrafluorophthalic anhydride.
    Type: Grant
    Filed: February 21, 1995
    Date of Patent: June 4, 1996
    Assignee: Asahi Glass Company Ltd.
    Inventors: Ryuji Seki, Koji Sugimoto, Seisaku Kumai
  • Patent number: 5457124
    Abstract: The invention relates to compounds selected from the group consisting of the formulas: ##STR1## wherein R.sup.2 and Ph are as described herein. These compounds are potent leukotriene B.sub.4 antagonists and are therefore useful in the treatment of inflammatory diseases.
    Type: Grant
    Filed: December 7, 1993
    Date of Patent: October 10, 1995
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Noal Cohen, Andrzej R. Daniewski, Ferdinand K. Lee, Keith A. Yagaloff
  • Patent number: 5434186
    Abstract: Compounds of the formula ##STR1## wherein X is O or CH.sub.2 ; Y is O, --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--, --C.tbd.C--, or --OCH.sub.2 C.sub.6 H.sub.4 --;Z is --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH-- or --C.tbd.C--;f, h, k, m and t, independently, are 0 or 1;n is an integer from 1 to 12;R.sup.1 is hydrogen, lower alkyl, lower alkenyl, cycloalkyl, or aralkyl; and A is B or --O--B, wherein B is a mono-, di- or tricyclic aromatic or heteroaromatic moiety substituted by the group --COR.sup.2, --(O).sub.t --(W).sub.s --COR.sup.2 or --(CH.dbd.CH).sub.p COR.sup.2 and which may also contain up to 4 additional substituents selected, independently, from the group consisting of halogen, cyano, lower alkyl, lower alkoxy, sulfonamido, alkanoyl, aroyl, --(Q).sub.k --(W).sub.s' --E or --(Q).sub.k --(W).sub.s" --C.sub.6 H.sub.4 --(W).sub.s'" --E, provided that no more than one of said substituents is --(Q).sub.k --(W).sub.s' --E or --(Q).sub.k --(W).sub.s" --C.sub.6 H.sub.4 --(W).sub.s'" --E, and wherein E is COR.sup.
    Type: Grant
    Filed: September 28, 1993
    Date of Patent: July 18, 1995
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Noal Cohen, Ferdinand K. Lee, Keith A. Yagaloff
  • Patent number: 5403952
    Abstract: Novel substituted cyclic compounds of Formula I are found to be useful inhibitors of matrix metalloendoproteinase-mediated diseases including osteoarthritis, rheumatoid arthritis, septic arthritis, tumor invasion in certain cancers, periodontal disease, corneal ulceration, proteinuria, dystrophic epidermolysis bullosa, and coronary thrombosis associated with atherosclerotic plaque rupture. The matrix metalloendoproteinases are a family of zinc-containing proteinases including but not limited to stromelysin, collagenase, and gelatinase, that are capable of degrading the major components of articular cartilage and basement membranes. The inhibitors claimed herein may also be useful in preventing the pathological sequelae following a traumatic injury that could lead to a permanent disability. These compounds may also be useful as novel birth control agents by preventing ovulation or implantation.
    Type: Grant
    Filed: October 8, 1993
    Date of Patent: April 4, 1995
    Assignee: Merck & Co., Inc.
    Inventors: William Hagmann, Charles G. Caldwell, Paul R. Gooley
  • Patent number: 5389619
    Abstract: Compounds of the formula I ##STR1## where n, W, X, Y, Z, R.sup.1, R.sup.2, and R.sup.3 are as defined herein exhibit fungicidal, insecticidal, and acaracidal activity.
    Type: Grant
    Filed: March 29, 1993
    Date of Patent: February 14, 1995
    Assignee: BASF Aktiengesellschaft
    Inventors: Reinhard Doetzer, Hubert Sauter, Horst Wingert, Reinhard Kirstgen, Albrecht Harreus, Gisela Lorenz, Eberhard Ammermann
  • Patent number: 5359125
    Abstract: Disclosed are certain novel 2,2'-bisacetoacetates useful as crosslinking agents and a process for the preparation therefor. Also provided are novel enamel compositions containing the crosslinkers and coatings and articles coated with thermosetting coating compositions crosslinked with these novel crosslinkers.
    Type: Grant
    Filed: August 9, 1993
    Date of Patent: October 25, 1994
    Assignee: Eastman Chemical Company
    Inventors: J. Stewart Witzeman, Allen L. Crain
  • Patent number: 5350872
    Abstract: The subject matter of the invention is a process for the preparation of carboxylic acids and derivatives of them of the general formula ##STR1## wherein R means hydrogen, or a C.sub.1-4 alkyl or a (C.sub.1-5 alkoxy)carbonyl group,R.sub.1 is as defined in claim 1,R.sub.7 stands for hydrogen or a C.sub.1-7 alkyl group andR.sub.8 means hydrogen or a carboxyl group,by reacting a 1,3-dioxane-4,6-dione derivative of the general formula ##STR2## wherein R.sub.9 stands for a C.sub.1-4 alkyl group or a phenyl group, optionally monosubstituted by halogen andR.sub.10 stands for hydrogen or a C.sub.1-5 alkyl group orR.sub.9 and R.sub.10 together form a pentamethylene group,and an aldehyde or ketone of the general formula ##STR3## in the presence of formic acid.
    Type: Grant
    Filed: October 29, 1993
    Date of Patent: September 27, 1994
    Assignee: Biogal Gyogyszergrar
    Inventors: Gyorgy Toth, Janos Balint, Klara Elek nee Herczik, Zsuzsanna Moricz nee Garai, Eva Mudra nee Kantor
  • Patent number: 5322794
    Abstract: Fluorescence probes are described comprising coronene fluorophores chemically attached to lipids or membrane-mimetic molecules via hydrocarbon spacers of defined length. Also described is a method for determining lipid packing and dynamics in membranes, a method for estimating hydrodynamic properties of macromolecules and macromolecular complexes, and a method for measuring changes in Ca.sup.+2 concentrations in or near membranes.
    Type: Grant
    Filed: February 16, 1993
    Date of Patent: June 21, 1994
    Inventor: Lesley Davenport
  • Patent number: 5196564
    Abstract: A novel compound of the formula (I): ##STR1## wherein R.sub.1 is esterified carboxyl; R.sub.2, R.sub.3 and R.sub.4 are the same or different and are hydrogen or alkyl; A is formyl, hydroxyiminomethyl or carboxyl; and X is hydrogen or halogen, or a salt thereof, which is useful as an aromatase inhibitor or an intermediate of its production. Processes for producing the compound of the formula (I) and an aromatase inhibitor containing as an active component the compound of the formula (I) wherein A is formyl and X is hydrogen or, a salt thereof as well as Penicillium funiculosum capable for producing the compound (I) wherein R.sub.1 is carboxyl, R.sub.2, R.sub.3 and R.sub.4 are hydrogen and X is formyl are also disclosed.
    Type: Grant
    Filed: February 27, 1991
    Date of Patent: March 23, 1993
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Tsuneo Kanamaru, Tsuneaki Hida, Masayuki Muroi
  • Patent number: 5191108
    Abstract: The invention relates to catechol carboxylic acid derivatives of the formula ##STR1## wherein, R.sub.1 is ##STR2## acetyl, hydrogen, hydroxy or alkanoyloxy, R.sub.2 is ##STR3## hydroxy, hydrogen or alkanoyloxy, wherein R is hydrogen, lower alkyl or --(CH.sub.2).sub.n --N--(lower alkyl).sub.2,R.sub.3 is hydrogen, lower alkyl or amino,R.sub.4 is hydrogen, lower alkyl, halogen or aminoA is ##STR4## wherein, R.sub.5 is hydrogen or acyl, R.sub.6 is hydrogen, halogen, lower alkyl, aryl or cycloalky, and R.sub.7 and R.sub.8, independently, are hydrogen, lower alkyl or halogen, orA is ##STR5## wherein, R.sub.5 is hydrogen or acyl, R.sub.9 is hydrogen, lower alkyl, R.sub.10 is hydrogen, lower alkyl or halogen, R.sub.11 is hydrogen, lower alkyl, cycloalkyl or halogen, m is 0 or 1, n is an integer of 2-10, provided, that no more than one of R.sub.1 or R.sub.2 can be hydroxy, alkanoyloxy or ##STR6## and when R is hydrogen, salts thereof with pharmaceutically acceptable bases or when R is --(CH.sub.2).sub.
    Type: Grant
    Filed: April 3, 1991
    Date of Patent: March 2, 1993
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Matthew Carson, Ru-Jen L. Han, Ronald A. Lemahieu
  • Patent number: 5152826
    Abstract: An herbicide compound of the formula ##STR1## wherein R is halogen, C.sub.1 -C.sub.2 alkyl, C.sub.1 -C.sub.2 alkoxy, nitro; cyano; C.sub.1 -C.sub.2 haloalkyl, or R.sup.a SO.sub.n -- wherein n is 0 or 2 and R.sup.a is C.sub.1 -C.sub.2 alkyl;R.sup.1 is hydrogen or C.sub.1 -C.sub.4 alkyl;R.sup.2 is hydrogen or C.sub.1 -C.sub.4 alkyl; orR.sup.1 and R.sup.2 together are alkylene having 2 to 5 carbon atoms;R.sup.3 is hydrogen or C.sub.1 -C.sub.4 alkyl;R.sup.4 is hydrogen or C.sub.1 -C.sub.4 alkyl; orR.sup.3 and R.sup.4 together are oxo;R.sup.5 is hydrogen or C.sub.1 -C.sub.4 alkyl;R.sup.6 is hydrogen or C.sub.1 -C.sub.4 alkyl; orR.sup.5 and R.sup.6 together are alkylene having 2 to 5 carbon atoms;R.sup.7 and R.sup.8 independently are (1) hydrogen; (2) halogen; (3) C.sub.1 -C.sub.4 alkyl; (4) C.sub.1 -C.sub.4 alkoxy; (5) trifluoromethoxy; (6) cyano; (7) nitro; (8) C.sub.1 -C.sub.4 haloalkyl; (9) R.sup.b SO.sub.n --wherein n is the integer 0, 1 or 2; and R.sup.b is (a) C.sub.1 -C.sub.4 alkyl; (b) C.sub.1 -C.sub.
    Type: Grant
    Filed: October 16, 1991
    Date of Patent: October 6, 1992
    Assignee: Imperial Chemical Industries PLC
    Inventor: Christopher G. Knudsen
  • Patent number: 5136081
    Abstract: The invention provides a process for the preparation of fungicidally active cyclopentene derivatives of the general formula ##STR1## cyclopentane derivatives of the general formula ##STR2## and cyclohexane derivatives of the general formula ##STR3## in which n, R, R.sup.1, R.sup.2, R.sup.5, X and Y are as herein defined. Compounds of formula II and III are also provided which are useful as intermediates in the preparation of certain fungicidally active cyclopentane derivatives.
    Type: Grant
    Filed: September 11, 1989
    Date of Patent: August 4, 1992
    Assignee: Shell Internationale Research Maatschappij B.V.
    Inventor: Paul H. Briner
  • Patent number: 5124083
    Abstract: There are disclosed 3-substituted and 3,3-disubstituted all-trans-4-oxoretinoic acids and 3-substituted and 3,3-disubstituted 13-cis-4-oxoretinoic acids and their lower alkyl esters.
    Type: Grant
    Filed: August 30, 1990
    Date of Patent: June 23, 1992
    Assignee: Southern Research Institute
    Inventor: Y. Fulmer Shealy
  • Patent number: 5081308
    Abstract: Sunscreen compositions are described which contain certain bis-1,3-diketone derivatives of cyclohexane when incorporated in a carrier in amounts ranging from 0.1-50% by weight.
    Type: Grant
    Filed: December 15, 1988
    Date of Patent: January 14, 1992
    Assignee: ICI Americas Inc.
    Inventor: Donald J. Gosciniak
  • Patent number: 5051527
    Abstract: The invention lies in novel ferroelectric liquid crystal compounds particularly represented by the general formulae, having a good responsibility in relation to the applied electric field and a wide range of phase transition points inclusive of the room temperature so as to be useful alone as the liquid crystal material but also to be mixed with other liquid crystal compounds for expanding the phase transition points to a desired range and making the response speed of the liquid crystal composition faster. ##STR1## In the formulae, m and n are same or different with each other and represent an integral of 1-20.
    Type: Grant
    Filed: February 28, 1989
    Date of Patent: September 24, 1991
    Assignee: Showa Shell Sekiyu K.K.
    Inventors: Yoshiichi Suzuki, Takashi Hagiwara, Hiroyuki Mogamiya