Preparing From A Compound Having A Nitrogen Containing Hetero Ring Patents (Class 562/18)
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Patent number: 7205431Abstract: Compositions containing surfactant compounds according to formula (I) ROCH2CH(OH)CR1R2ZCR1R2CH(OH)CH2OR,??(I) wherein Z is S, SO, or SO2, can have a range of equilibrium and/or dynamic surface tensions and a range of foaming performance attributes, depending upon the particular values of Z, R, R1, and R2. The compounds of formula (I) may be prepared by a process that includes reaction of a sulfide source such as a metal sulfide or bisulfide with an alkyl glycidyl ether. The compounds may be useful in any of a broad range of applications requiring the use of a surfactant.Type: GrantFiled: March 10, 2005Date of Patent: April 17, 2007Assignee: Air Products and Chemicals, Inc.Inventors: Gauri Sankar Lal, Williams Rene Edouard Raymond, Khalil Yacoub
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Patent number: 7145034Abstract: The invention relates to a process for preparing N-phosphono-methylglycine by reacting a hexahydrotriazine compound with a triacyl phosphite in an organic solvent, hydrolyzing the resulting phosphono compound after prior extraction into an aqueous phase and separation from the organic phase. The process avoids decomposition of the organic solvent during hydrolysis.Type: GrantFiled: June 21, 2002Date of Patent: December 5, 2006Assignee: BASF AktiengesellschaftInventors: Christian Wulff, Stefan Orsten, Alfred Oftring, Peter Zehner
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Patent number: 7132466Abstract: The invention relates to a compound of the general formula: Z1-O-[m(R1PO3),n(R2HPO3]Z2, represent a copolyphosphate, with m (R1PO3) units and n (R2HPO3) units; R3 represents an ammonium building block; R2 represents a 1,3,5-triazine building block; Z1 and Z2 represent ammonium or 1,3,5-triazine building blocks, to be chosen independently of each other; m and n represent whole numbers greater than or equal to 1; and m+n numbers greater than 3. The invention further relates to a method for the preparation of the above compound and to flame-retardant polymer compositions in which compounds with the above formula are applied as flame retardant, the use of the halogen-free compound in a coating composition and a substrate containing a coating formed from the coating composition that has been cured.Type: GrantFiled: October 1, 2002Date of Patent: November 7, 2006Assignee: Ciba Specialty Chemicals CorporationInventors: Renier Henricus Maria Kierkels, Nicolaas Johanna Jozef Aelmans, Patricia Hubertina Cornelis Grolleman, Adrianus Wilhelmus Maria Braam
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Publication number: 20040236145Abstract: The invention relates to a process for preparing N-phosphono-methylglycine by reacting a hexahydrotriazine compound with a triacyl phosphite in an organic solvent, hydrolyzing the resulting phosphono compound after prior extraction into an aqueous phase and separation from the organic phase. The process avoids decomposition of the organic solvent during hydrolysis.Type: ApplicationFiled: December 22, 2003Publication date: November 25, 2004Inventors: Christian Wulff, Stefan Orsten, Alfred Oftring, Peter Zehner
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Patent number: 6818793Abstract: The present invention relates to a process for the preparation of N-phosphonomethylglycine by reacting a hexahydrotriazine derivative with a triacyl phosphite. The process gives N-phosphonomethylglycine in high yield and in a simple and inexpensive manner.Type: GrantFiled: June 24, 2002Date of Patent: November 16, 2004Assignee: BASF AktiengesellschaftInventors: Christian Wulff, Stefan Orsten, Alfred Oftring
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Publication number: 20040092765Abstract: The present invention relates to a process for the preparation of N-phosphonomethylglycine by reacting a hexahydrotriazine derivative with a triacyl phosphite. The process gives N-phosphonomethylglycine in high yield and in a simple and inexpensive manner.Type: ApplicationFiled: October 6, 2003Publication date: May 13, 2004Inventors: Christian Wulff, Stefan Orsten, Alfred Oftring
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Publication number: 20040063996Abstract: The present invention relates to a process for the preparation of N-phosphonomethylglycine by reacting a hexahydrotriazine derivative with a triacyl phosphite. The process gives N-phosphonomethylglycine in high yield and in a simple and inexpensive manner.Type: ApplicationFiled: September 22, 2003Publication date: April 1, 2004Inventors: Christian Wulff, Stefan Orsten, Alfred Oftring
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Patent number: 6692764Abstract: Pharmaceutical compositions of bisphosphonic acids, and salts thereof, are prepared by wet granulation tablet formulation. These pharmaceutical compositions are useful in the treatment of disturbances involving calcium or phosphate metabolism, in particular, the treatment and prevention of diseases involving bone resorption, especially osteoporosis, Paget's disease, malignant hypercalcemia, and metastatic bone disease. These compositions are prepared without the addition of binder; instead, the drug itself acts as a binder.Type: GrantFiled: September 23, 2002Date of Patent: February 17, 2004Assignee: Merck & Co., Inc.Inventors: Ashok V. Katdare, Kenneth A. Kramer
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Publication number: 20030166966Abstract: The present invention relates to a process for the preparation of N-phosphonomethylglycine by reacting a hexahydrotriazine derivative with a triacyl phosphite. The process gives N-phosphonomethylglycine in high yield and in a simple and inexpensive manner.Type: ApplicationFiled: February 20, 2003Publication date: September 4, 2003Inventors: Christian Wulff, Stefan Orsten, Alfred Oftring
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Publication number: 20030004370Abstract: The present invention relates to a process for the preparation of N-phosphonomethylglycine by reacting a hexahydrotriazine derivative with a triacyl phosphite. The process gives N-phosphonomethylglycine in high yield and in a simple and inexpensive manner.Type: ApplicationFiled: June 24, 2002Publication date: January 2, 2003Inventors: Christian Wulff, Stefan Orsten, Alfred Oftring
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Patent number: 6278017Abstract: A process for the continuous production of N-(phosphonomethyl)glycine is provided. In the process, N-(acetyl)iminodiacetic acid is formed in an amidocarboxymethylation reactor system. The N-(acetyl)iminodiacetic acid product stream is either: (1) reacted with a source of phosphorous and a source of formaldehyde in the presence of an acid to form a phosphonomethylation reaction product stream containing N-(phosphonomethyl)iminodiacetic acid and acetic acid; or (2) deacylated and cyclized to form a 2,5-diketopiperazine, and then reacted with a source of phosphorous and a source of formaldehyde in the presence of an acid to form a phosphonomethylation reaction product stream containing N-(phosphonomethyl)iminodiacetic acid and acetic acid. In either case, the N-(phosphonomethyl)iminodiacetic acid product is recovered and converted to N-(phosphonomethyl)glycine.Type: GrantFiled: July 10, 2000Date of Patent: August 21, 2001Assignee: Monsanto CompanyInventors: Michael K. Stern, Todd J. Johnson, Amy L. Jorgenson, Michael D. Rogers, Thaddeus S. Franczyk, II
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Patent number: 6130351Abstract: A process for the production of N-(phosphonomethyl)iminodiacetic acid. N-(acetyl)iminodiacetic acid is formed in a amidocarboxymethylation reactor system, into which a source of each of the following is continuously fed: (1) acetamide or an acetamide derivative, (2) formaldehyde or a formaldehyde generator or derivative, (3) a carbonylation catalyst, (4) carbon monoxide, and optionally (5) hydrogen. In turn, an amidocarboxymethylation reaction product stream, which contains N-(acetyl)iminodiacetic acid and the carbonylation catalyst, is withdrawn from the amidocarboxymethylation reactor system. The carbonylation catalyst is separated from the amidocarboxymethylation reaction product stream to recover the carbonylation catalyst and form a catalyst depleted product stream which contains N-(acetyl)iminodiacetic acid.Type: GrantFiled: August 12, 1999Date of Patent: October 10, 2000Assignee: Monsanto CompanyInventors: Michael K. Stern, Todd J. Johnson, Amy L. Jorgenson, Michael D. Rogers, Thaddeus S. Franczyk, II
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Patent number: 5563121Abstract: A peptide linkage unit is employed for joining peptide and pseudopeptide sequences, including peptides and pseudopeptides that inhibit aspartic proteinase enzymes. The peptide linkage unit includes a phosphinate methylene ammonium linkage in place of a peptidyl carboxamide bond. If the peptide linkage unit is incorporated into a peptide sequence that would otherwise serve as an aspartic proteinase substrate and if it is positioned at a cleavage site within such peptide sequence, the phosphinate methylene ammonium linkage is resistant to cleavage and serves as an exploding transition state analog of such cleavage site. When so incorporated, the phosphinate methylene ammonium linkage can bind or interfere with the active site of aspartic proteinase enzymes and inhibit its activity. Preferred inhibitors contain a phosphinic acid methylene amine group joining the P.sub.1 and P.sub.1 ' residues and have a length of 3 to about 15 amino acid residues.Type: GrantFiled: June 30, 1994Date of Patent: October 8, 1996Assignee: The Scripps Research InstituteInventors: Kim D. Janda, Peter Wirsching, Shoji Ikeda
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Patent number: 5500485Abstract: N-Phosphonomethylglycine and its salts are manufactured by hydrolysing N-phosphonomethyl-2-oxazolidinone in an aqueous medium and thereafter oxidising the hydrolysis product in an aqueous alkaline medium using an oxygen-containing gas in the presence of an oxidation catalyst, for example a platinum or palladium catalyst optionally containing a promoter such as bismuth.Type: GrantFiled: June 20, 1994Date of Patent: March 19, 1996Inventor: Ian Hodgkinson
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Patent number: 5284970Abstract: The present invention describes a novel compound, 2-azabicyclo[2.2.1]hept-5-ene-2-acetic acid, its preparation and the preparation of related compounds, and the use of said compounds as intermediates for the preparation of N-phosphonomethylglycine.Type: GrantFiled: June 26, 1992Date of Patent: February 8, 1994Assignee: American Cyanamid CompanyInventor: David A. Cortes
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Patent number: 5053529Abstract: There is disclosed a novel process for the preparation of N-phosphonomethylglycine of formula(I) ##STR1## (wherein, R and R.sup.1 are selected from the group consisting of alkyl having 1 to 2 carbon atoms) which process comprises reacting 1,3,5-tricarboalkoxymethylhexahydro-s-triazine with trialkylphosphite in the presence of titanium tetrachloride to form N-phosphonomethylglycine triester and converting the triester into a N-phosphonomethylglycine by saponification.Type: GrantFiled: November 2, 1990Date of Patent: October 1, 1991Assignee: Korea Institute of Science and TechnologyInventors: Hyun-Joon Ha, Kyong Pae Park