Halogen Attached Indirectly To The Phosphorus By Nonionic Bonding Patents (Class 562/25)
  • Patent number: 8940927
    Abstract: The present invention provides for novel compounds of Formulas I and II and pharmaceutically acceptable salts and co-crystals thereof which have glucokinase activator activity. The present invention further provides for pharmaceutical compositions comprising the same as well as methods of treating, preventing, delaying the time to onset or reducing the risk for the development or progression of a disease or condition for which one or more glucokinase activator is indicated, including Type 1 and 2 diabetes, impaired glucose tolerance, insulin resistance and hyperglycemia. The present invention also provides for processes of making the compounds of Formulas I and II, including salts and co-crystals thereof, and pharmaceutical compositions comprising the same.
    Type: Grant
    Filed: May 25, 2011
    Date of Patent: January 27, 2015
    Assignee: Metabasis Therapeutics, Inc.
    Inventors: Feng Tian, Qun Dang, G. Sridhar Prasad, Wenyu Li, Brett C. Bookser, Nicholas Brian Raffaele, Mark D. Erion
  • Patent number: 8912124
    Abstract: The invention relates to derivatives of (1-cyanocyclopropyl)phenylphosphinic acid of the formula (I) and to salts thereof, of the formula (II), for enhancing stress tolerance in plants to abiotic stress, preferably to drought stress, especially for enhancing plant growth and/or for increasing plant yield.
    Type: Grant
    Filed: April 6, 2011
    Date of Patent: December 16, 2014
    Assignee: Bayer Cropscience AG
    Inventors: Lothar Willms, Hans-Joachim Zeiβ, Marco Busch, Christopher Hugh Rosinger, Ines Heinemann, Isolde Häuser-Hahn, Martin Jeffrey Hills, Pascal Von Koskull-Döring
  • Publication number: 20140155649
    Abstract: The invention relates to a process for the preparation of bis(perfluoroalkyl)phosphinic acid anhydrides by reaction of a bis(perfluoroalkyl)phosphinic acid with phosphorus pentoxide, to novel bis(perfluoroalkyl)phosphinic acid anhydrides and to uses of bis(perfluoroalkyl)phosphinic acid anhydrides.
    Type: Application
    Filed: July 6, 2012
    Publication date: June 5, 2014
    Applicant: MERCK PATENT GMBH
    Inventors: Nikolai (Mykola) Ignatyev, Waldemar Wiebe, Helge Willner
  • Patent number: 8361215
    Abstract: Disclosed is an emulsifier comprising, as an active ingredient, a polyfluoroalkylphosphonic acid salt represented by the general formula: CnF2n+1(CH2CF2)a(CF2CF2)b(CH2CH2)cP(O)(OM1)(OM2), wherein M? is a hydrogen atom, an alkali metal, an ammonium base, or an organic amine base, M2 is an alkali metal, an ammonium base, or an organic amine base, n is an integer of 1 to 6, a is an integer of 1 to 4, b is an integer of 1 to 3, and c is an integer of 1 to 3. An aqueous solution or organic solvent solution of the emulsifier can be effectively used to emulsify a perfluoropolyether oil or a perfluorocarbon compound. The resulting emulsion exhibits excellent emulsification stability, and thus can be effectively used as a mold-releasing agent.
    Type: Grant
    Filed: October 7, 2010
    Date of Patent: January 29, 2013
    Assignee: Unimatec Co., Ltd.
    Inventors: Yoshiyama Kaneumi, Seiichiro Murata, Katsuyuki Sato
  • Publication number: 20120264946
    Abstract: The present invention relates to a process for the preparation of compounds with (perfluoroalkyl)fluorohydrogenphosphate anion, and to compounds containing (perfluoroalkyl)fluorohydrogenphosphate anion and to the use thereof.
    Type: Application
    Filed: December 6, 2010
    Publication date: October 18, 2012
    Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
    Inventors: Nikolai (Mykola) Ignatyev, Michael Schulte, Anne Julia Bader, Berthhold Theo Hoge
  • Publication number: 20120190650
    Abstract: Stabilized benzyl phosphonic acid and naphthyl phosphonic acid analog compounds are effective in inhibiting the activity of autotaxin.
    Type: Application
    Filed: January 19, 2012
    Publication date: July 26, 2012
    Applicant: University of Tennessee Research Foundation
    Inventors: Renuka Gupte, Renukadevi Patil, Gabor Tigyi, Duane D. Miller
  • Publication number: 20110315050
    Abstract: Disclosed is a polyfluoroalkylphosphonic acid represented by the general formula: CnF2n+1(CH2CF2)a(CF2CF2)b(CH2CH2)cP(O)(OH)2, wherein n is an integer of 1 to 6, a is an integer of 1 to 4, b is an integer of 1 to 3, and c is an integer of 1 to 3, or a salt thereof, which is a compound having a perfluoroalkyl group containing 6 or less carbon atoms, which is said to have low bioaccumulation potential, and being usable as an active ingredient of a mold-releasing agent. The polyfluoroalkylphosphonic acid is produced by hydrolyzing a polyfluoroalkylphosphonic acid diester represented by the general formula: CnF2n+1(CH2CF2)a(CF2CF2)b(CH2CH2)cP (O)(OR)2, wherein R is a C1-C4 alkyl group, n is an integer of 1 to 6, a is an integer of 1 to 4, b is an integer of 1 to 3, and c is an integer of 1 to 3.
    Type: Application
    Filed: March 9, 2010
    Publication date: December 29, 2011
    Applicant: UNIMATEC CO., LTD.
    Inventors: Yoshiyama Kaneumi, Seiichiro Murata, Katsuyuki Sato
  • Patent number: 7999049
    Abstract: An emulsion polymerization process for the production of fluoroelastomers is disclosed wherein at least one fluorosurfactant is employed as dispersant, said fluorosurfactant being a fluoroalkylphosphoric acid ester of the formula X—Rf-(CH2)n—O—P(O)(OM)2, wherein n=1 or 2, X=H or F, M=a univalent cation, and Rf is a C4-C6 fluoroalkyl or fluoroalkoxy group. Optionally, a second dispersing agent may be employed in the polymerization, said second agent being a perfluoropolyether having at least one endgroup selected from the group consisting of carboxylic acid, a salt thereof, sulfonic acid and a salt thereof, phosphoric acid and a salt thereof.
    Type: Grant
    Filed: January 15, 2009
    Date of Patent: August 16, 2011
    Assignee: DuPont Performance Elastomers L.L.C.
    Inventors: Michael Cregg Coughlin, Ming-Hong Hung, Phan Linh Tang
  • Patent number: 7989566
    Abstract: An emulsion polymerization process for the production of non-elastomeric fluoropolymers is disclosed wherein at least one fluorosurfactant is employed as dispersant, said fluorosurfactant being a fluoroalkylphosphoric acid ester of the formula X-Rf-(CH2)n—O—P(O)(OM)2, wherein n is 1 or 2, X?H or F, M=a univalent cation, and Rf is a C4-C6 fluoroalkyl or fluoroalkoxy group. Optionally, a second dispersing agent may be employed in the polymerization, said second agent being a perfluoropolyether having at least one endgroup selected from the group consisting of carboxylic acid, a salt thereof, sulfonic acid and a salt thereof, phosphoric acid and a salt thereof.
    Type: Grant
    Filed: January 15, 2009
    Date of Patent: August 2, 2011
    Assignee: DuPont Performance Elastomers LLC
    Inventors: Michael Cregg Coughlin, Ming-Hong Hung
  • Publication number: 20110130589
    Abstract: The invention relates to a process for the preparation of bis(fluoroalkyl)phosphinic acid and/or fluoroalkylphosphonic acid by reaction of, monofluoroalkyltetrafluorophosphorane bis(fluoroalkyl)trifluorophosphorane or tris(fluoroalkyl)difluorophosphorane with water.
    Type: Application
    Filed: July 8, 2009
    Publication date: June 2, 2011
    Applicant: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Nikolai Mykola Ignatyev, Dana Bejan, Helge Willner
  • Publication number: 20110114935
    Abstract: One embodiment is a method, comprising: depositing a molecule on an electrode, wherein the electrode has a surface and the molecule has a binding group (e.g., an anchoring group) that binds to the surface, thereby providing a work function that is stable for at least 100 hours under ambient conditions.
    Type: Application
    Filed: July 15, 2009
    Publication date: May 19, 2011
    Applicant: GEORGIA TECH RESEARCH CORPORATION
    Inventors: Asha Sharma, Peter Hotchkiss, Benoit Domercq, Seth Marder, Bernard Kippelen
  • Patent number: 7655722
    Abstract: The present invention relates to adhesive compositions having: a phosphate group-containing monomer (a) having a fluorocarbon group represented by Chemical Formula 1; and a solvent (b), where R is a hydrogen atom or a methyl group, n, p and q are natural numbers 2?n?10, p+q?n and p+q+n?13.
    Type: Grant
    Filed: April 13, 2006
    Date of Patent: February 2, 2010
    Assignee: Kuraray Medical Inc.
    Inventors: Kazumitsu Nakatsuka, Naoki Nishigaki, Mitsunobu Kawashima
  • Patent number: 6919322
    Abstract: Novel FBPase inhibitors of the formula I are useful in the treatment of diabetes and other conditions associated with elevated blood glucose.
    Type: Grant
    Filed: March 7, 2001
    Date of Patent: July 19, 2005
    Assignee: Metabasis Therapeutics, Inc.
    Inventors: Brett C. Bookser, Qun Dang, K. Raja Reddy
  • Patent number: 6891057
    Abstract: Novel compounds comprising a C—C double bond substituted at one carbon with two oxygen or sulfur atom-containing groups are disclosed. The compounds are useful in methods and compositions for generating chemiluminescence by reaction with a peroxidase enzyme and a peroxide. The chemiluminescence thus produced can be used as a detectable signal in assays for peroxidase enzymes and in assays employing enzyme-labeled specific binding pairs.
    Type: Grant
    Filed: January 9, 2004
    Date of Patent: May 10, 2005
    Assignee: Lumigen, Inc.
    Inventors: Hashem Akhavan-Tafti, Zahra Arghavani, Renuka DeSilva
  • Publication number: 20040198702
    Abstract: Functional trifluorovinyl monomers and their copolymerization with fluoroolefins Functional trifluorovinyl monomers, process for the copolymerization of trifluorovinyl monomers with fluoroolefins and use of these trifluorovinyl monomers in forming fluoroelastomers.
    Type: Application
    Filed: April 26, 2004
    Publication date: October 7, 2004
    Applicant: SOLVAY S.A.
    Inventors: Petya Petrova, Bruno Ameduri, Georges Kostov, Bernard Boutevin
  • Publication number: 20030194162
    Abstract: Compounds of formula (I), methods of making and method of using (including optical compositions and devices) are provided.
    Type: Application
    Filed: August 26, 2002
    Publication date: October 16, 2003
    Inventors: Robert M. Mininni, Yousef Mohajer, Anthony Garito, Anna A. Panackal, Joseph Virgilo
  • Publication number: 20030189193
    Abstract: Compounds of formula (I), methods of making and method of using (including optical compositions and devices) are provided.
    Type: Application
    Filed: August 26, 2002
    Publication date: October 9, 2003
    Inventors: Robert M. Mininni, Yousef Mohajer, Anthony Garito, Anna A. Panackal, Joseph A. Virgilio
  • Patent number: 6486142
    Abstract: The invention encompasses the novel class of compounds represented by formula I, which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes, obesity, and conditions related to diabetes.
    Type: Grant
    Filed: December 21, 2000
    Date of Patent: November 26, 2002
    Assignee: Merck Frosst Canada & Co.
    Inventors: Yves Leblanc, Claude Dufresne, Jacques Yves Gauthier, Cheuk Kun Lau, Chun Sing Li, Patrick Roy, Michel Therien, John Scheigetz, Zhaoyin Wang
  • Patent number: 6486141
    Abstract: The invention encompasses the novel class of compounds represented by formula I which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes, obesity, and diabetes-related conditions.
    Type: Grant
    Filed: December 21, 2000
    Date of Patent: November 26, 2002
    Assignee: Merck Frosst Canada & Co.
    Inventors: Cheuk Kun Lau, Christopher Bayly, Jacques Yves Gauthier, Yves Leblanc, Chun Sing Li, Patrick Roy, Michel Therien, Zhaoyin Wang
  • Patent number: 6448429
    Abstract: The invention encompasses the novel class of compounds represented by formula I, which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes, obesity, and diabetes-related diseases.
    Type: Grant
    Filed: December 21, 2000
    Date of Patent: September 10, 2002
    Assignee: Merck Frosst Canada & Co.
    Inventors: Yves Leblanc, Claude Dufresne, Jacques Yves Gauthier, Robert Young
  • Patent number: 6410782
    Abstract: Diphosphonates or their salts between acids and linear, branch substituted and non-substituted, cyclic, heterocyclic and aromatic amino alcohols are used to treat osteoporosis. Pharmaceutical compositions and therapeutic methods of treating osteoporosis are described.
    Type: Grant
    Filed: April 3, 2000
    Date of Patent: June 25, 2002
    Assignees: Geange Ltd., Eurodrug Ltd., Lipotec SA
    Inventors: Fred VanGulik, Antonio Parente
  • Patent number: 6355833
    Abstract: A catalyst comprising at least one nickel(O) complex which comprises at least one mono-, bi- or multidentate phosphonite ligand of the formula I or salts and mixtures thereof, is prepared as described, and the catalysts are used to prepare mixtures of monoolefinic C5 mononitriles with nonconjugated C═C and C≡N bonds by catalytic hydrocyanation of butadiene or of a 1,3-butadiene-containing hydrocarbon mixture in the presence of a catalyst of this type.
    Type: Grant
    Filed: February 14, 2001
    Date of Patent: March 12, 2002
    Assignee: BASF Aktiengesellschaft
    Inventors: Jakob Fischer, Wolfgang Siegel
  • Patent number: 6333426
    Abstract: Opticallly active adsorbents based on network polymerized derivative of dicarboxylic acids, diamines or diols which are chemically bonded to a carrier. The derivatives can be polymerized by radical polymerization or through hydrosilylation in the presence of a solid carrier. The optically active adsorbents are usable for chromatographic separation of racemic mixtures of enantiomers.
    Type: Grant
    Filed: September 28, 1999
    Date of Patent: December 25, 2001
    Assignee: EKA Nobel AB
    Inventors: Per Moller, Domingo Sanchez, Stig Allenmark, Shalini Andersson
  • Patent number: 6245928
    Abstract: Stable, enzymatically triggered chemiluminescent 1,2-dioxetanes with improved water solubility and storage stability are provided as well as synthetic processes and intermediates used in their preparation. Dioxetanes further substituted with two or more water-solubilizing groups disposed on the dioxetane structure and an additional fluorine atom or lower alkyl group provide superior performance by eliminating the problem of reagent carryover when used in assays performed on capsule chemistry analytical systems. These dioxetanes display substantially improved stability on storage. Compositions comprising these dioxetanes, a non-polymeric cationic surfactant enhancer and optionally a fluorescer, for providing enhanced chemiluminescence are also provided.
    Type: Grant
    Filed: February 17, 2000
    Date of Patent: June 12, 2001
    Assignee: Lumigen, Inc.
    Inventors: Zahra Arghavani, Hashem Akhavan-Tafti, Renuka DeSilva, Kumar Thakur
  • Patent number: 5840963
    Abstract: Novel methods and compositions which generate chemiluminescence are provided. The compositions comprise a heterocyclic enol phosphate compound and a dihydroxyaromatic compound in which the two hydroxy groups are separated by an even number of ring carbon atoms. Novel methods and compositions for generating chemiluminescence by reaction with a hydrolytic enzyme are provided as well. The compositions comprise a heterocyclic enol phosphate compound and a protected dihydroxyaromatic compound in which one of the hydroxy groups of the dihydroxyaromatic compound is protected with an enzyme-cleavable group. The novel chemiluminescent compositions are useful in methods for producing chemiluminescence for use in assays of hydrolytic enzymes and enzyme inhibitors and in assays employing labeled specific binding pairs.
    Type: Grant
    Filed: February 10, 1998
    Date of Patent: November 24, 1998
    Assignee: Lumigen, Inc.
    Inventor: Hashem Akhavan-Tafti
  • Patent number: 5616785
    Abstract: Hydroformylation of alkenes to aldehydes in the presence of a rhodium complex catalyst is improved by the addition of a novel bidentate ligand of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.1.sup.' are organic radicals selected from alicyclic, aliphatic and aromatic groups of which at least one is preferably substituted with at least one electronegative moiety and the methylene groups are present at the trans-2,3 positions on the norbornane moiety. The invention also provides a novel method for producing the bidentate ligand and novel intermediate phosphine oxide and phosphinous acid compounds.
    Type: Grant
    Filed: April 10, 1996
    Date of Patent: April 1, 1997
    Assignee: Hoechst Celanese Corporation
    Inventors: Jerry D. Unruh, Brigitte E. Segmuller, Gabriel R. Chapa, Kent E. Pryor
  • Patent number: 5132444
    Abstract: A process for the preparation of vinyl phosphonic derivatives of the general formula I ##STR1## in which R.sup.1 and R.sup.2 are the same or different and may stand for hydrogen or a C.sub.1 -C.sub.8 -alkyl, a C.sub.6 -C.sub.10 -aryl, or a C.sub.8 -C.sub.10 -aralkyl radical optionally substituted by Cl or Br, and in which R.sup.1 and R.sup.2 may alternatively be joined together to form an alicyclic ring having from 3 to 12 carbon atoms in the ring, wherein an ethane phosphonic ester of the general formula II ##STR2## in which R.sup.3 and R.sup.4 have the meanings stated above for R.sup.1 and R.sup.2 except for hydrogen and X denotes a hydroxy group, a halogen atom, or a radical of the formula--OR.sup.5,in which R.sup.5 is a hydrogen atom or a radical of the formula ##STR3## in which R.sup.6 is a C.sub.1 -C.sub.6 -alkyl radical or an alicyclic ring, is converted in the gas phase in the presence of a solid catalyst.
    Type: Grant
    Filed: April 22, 1991
    Date of Patent: July 21, 1992
    Assignee: BASF Aktiengesellschaft
    Inventors: Andreas Northemann, Martin Fischer, Ludwig Wambach
  • Patent number: 5107011
    Abstract: Compounds which are inhibitors of cholesterol biosynthesis (by inhibiting de novo squalene biosynthesis), and thus are useful as hypocholesterolemic agents and antiatherosclerotic agents, are provided which have the structure ##STR1## wherein R.sup.2 is a metal ion, lower alkyl or H; R.sup.3 is a metal ion or lower alkyl;R is R.sup.1 --(CH.sub.2).sub.n --, R.sup.1 --(CH.sub.2).sub.m --O-- or R.sup.1 --(CH.sub.2).sub.m --OCH.sub.2 --, wherein n is 1 to 4 and m is 0 to 3, andR.sup.1 is R.sup.5 --Q.sup.1 --Q.sup.2 --Q.sup.3 -- wherein R.sup.5, Q.sup.1, Q.sup.2 and Q.sup.3 are as defined herein.New intermediates, new methods of preparation and a method for using such compounds to inhibit cholesterol biosynthesis are also provided.
    Type: Grant
    Filed: February 5, 1991
    Date of Patent: April 21, 1992
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Scott A. Biller