Additional Nitrogen Bonded Directly To The -c(=x)- Group (e.g., Urea Halides, Etc.) Patents (Class 562/801)
  • Processes for preparing flutamide compounds and compounds prepared by such processes
    Patent number: 6228401
    Abstract: The present invention provides processes for preparing compounds comprising flutamide API having a specific surface area of at least 0.35 m2/cm3 which comprise blending pharmaceutically acceptable diluents with unmilled flutamide API and milling the blended material until the specific surface area is at least 0.35 m2/cm3. The present invention also provides compounds prepared by such processes.
    Type: Grant
    Filed: October 11, 2000
    Date of Patent: May 8, 2001
    Inventors: Jack Lawrence James, Louis Frank Molnar, Jr., Tania E. Toney-Parker
  • Hydroxamic acid derivatives as metalloproteinase inhibitors
    Patent number: 5861436
    Abstract: The present invention relates to therapeutically active hydroxamic acid derivatives, to pharmaceutical compositions containing them, and to the therapeutic use of these compounds. In particular, the compounds are inhibitors of matrix metalloproteinases that are involved in tissue degradation, and in addition, are inhibitors of the release of tumor necrosis factor from cells.
    Type: Grant
    Filed: April 29, 1997
    Date of Patent: January 19, 1999
    Assignee: British Biotech Pharmaceuticals Limited
    Inventors: Raymond Paul Beckett, Mark Whittaker, Andrew Miller
  • Hydroxamic and carbocyclic acids as metalloprotease inhibitors
    Patent number: 5691381
    Abstract: The present invention provides novel hydroxamic acids and carbocyclic acids and derivatives thereof and to pharmaceutical compositions and methods of use of these novel compounds for the inhibition of matrix metalloproteinases, such as stromelysin, and inhibit the production of tumor necrosis factor alpha, and for the treatment of arthritis and other related inflammatory diseases.
    Type: Grant
    Filed: April 16, 1996
    Date of Patent: November 25, 1997
    Assignee: The DuPont Merck Pharmaceutical Company
    Inventors: Irina Cipora Jacobson, Carl Peter Decicco, Robert Joseph Cherney