Abstract: The disclosure provides a method for synthesizing paraphthaloyl chloride through terephthalic acid chlorination in a reaction mode of a microchannel continuous flow. Compared with an existing technology, this method has characteristics of accurate control of reaction conditions, high phosgene/triphosgene utilization ratio, low catalyst dosage, high TPA conversion ratio within few tens of seconds of reaction time, high TPC yield and the like.

Abstract: This invention relates to a method for producing a carboxylic acid chloride, which efficiently decomposes a Vilsmeier reagent type compound in a carboxylic acid chloride lacking a thermal stability or a carboxylic acid chloride hardly distilled in practice due to a high boiling point with a simple operation and has no adverse effect on a subsequent step, and more particularly to a method for producing a carboxylic acid chloride, characterized by comprising reacting a carboxylic acid with a chlorinating agent in the presence of a catalyst, removing the excessive chlorinating agent from a reaction system after the reaction, and then further adding 1.0 to 3.0 equivalents of the starting carboxylic acid based on the catalyst to the reaction system to decompose a Vilsmeier reagent type compound remaining in the reaction system.

Abstract: The present invention relates to a process for producing chlorothioformate comprising reacting an alkenyl mercaptan with phosgene in a reactor in the presence of a carboxylic acid amide in an organic solvent, characterized in that the carboxylic acid amide is preliminary charged to the reactor in an amount of 10 to 50% by weight based on the whole amount of the carboxylic acid amide, and subsequently, the compound of the formula (I), phosgene and the remaining carboxylic acid amide are charged to the reactor.

Abstract: This invention relates to a method for producing a carboxylic acid chloride, which efficiently decomposes a Vilsmeier reagent type compound in a carboxylic acid chloride lacking a thermal stability or a carboxylic acid chloride hardly distilled in practice due to a high boiling point with a simple operation and has no adverse effect on a subsequent step, and more particularly to a method for producing a carboxylic acid chloride, characterized by comprising reacting a carboxylic acid with a chlorinating agent in the presence of a catalyst, removing the excessive chlorinating agent from a reaction system after the reaction, and then further adding 1.0 to 3.0 equivalents of the starting carboxylic acid based on the catalyst to the reaction system to decompose a Vilsmeier reagent type compound remaining in the reaction system.

Abstract: The process for producing a (fluoroalkyl)benzene derivative according to the present invention comprises a step of reducing the total content of group 3 to group 12 transition metals in an alkylbenzene derivative to 500 ppm or less in terms of metal atoms; a step of halogenating the branched alkyl group of the purified alkylbenzene derivative by a photohalogenation to obtain a (haloalkyl)benzene derivative; and a step of subjecting the (haloalkyl)benzene derivative to a halogen-fluorine exchange using HF in an amount of 10 mol or higher per one mole of the (haloalkyl)benzene derivative. The (fluoroalkyl)benzene derivative produced by the process is reduced in the content of impurities such as residual halogens and residual metals, and is useful as intermediates for functional chemical products for use in applications such as medicines and electronic materials.

Abstract: A process is disclosed for using bis-(trichloromethyl)carbonate (triphosgene), diphosgene or phosgene as efficient and effective coupling reagents during coupling of carbohydrates to peptide chains. This process is particularly useful for the coupling to sterically hindered amino acid residues, or for other difficult couplings. The reagents can be used for the derivatization of peptides by formation of a bond between a free amine on a peptide and a carbohydrate.

Abstract: The invention relates to a method for producing acid chlorides by converting carboxylic acids with carbon oxychlorides or thionyl chloride in the presence of a catalyst adduct of an N,N-disubstituted formamide of general formula (I) and carbon oxychloride or thionyl chloride. In the formula, R1 and R2, independently from one another, mean C1- to C4-alkyl or R1 and R2 together mean a C4- or C5-alkylene chain. According to the inventive method, hydrogen chloride is added during and/or after the conversion.

Abstract: The invention relates to a method for producing o-choromethyl benzenecarbonyl chlorides of formula (I), wherein R1-R4 can be the same or different and stand for hydrogen, C1-C4-alkyl, halogen or trifluoromnethyl, by converting benzocondensed lactones of formula (II), wherein R1-R4 have the aforementioned meaning, with gaseous or liquid phosgene and the dimers or trimers thereof.

Abstract: A process for preparing chlorocarbonyl chlorides of the formula (I) 1

Abstract: A process for the preparation of chlorocarboxylic chlorides of formula (I) 1

Abstract: The invention relates to a process for the preparation of acid chlorides by reaction of carboxylic acids, carboxylic anhydrides, cyclic carboxylic esters or sulfonic acids with phosgene in the presence of a catalytic amount of a compound from the group consisting of N,N,N′,N′-tetrasubstituted amidinium halides (I), N,N,N′-trisubstituted amidinium hydrohalides (II) and N,N,N′-trisubstituted amidines (III).

Abstract: A process that can be used to produce an acid anhydride or acid chloride is provided. The process comprises contacting a reaction medium with a catalyst. The reaction medium comprises at least one organic acid, combination of the organic acid and phosgene, combination of at least one organic anhydride and phosgene, or combinations of the organic acid, the organic anhydride, and phosgene. The reaction medium can further comprise a solvent. The catalyst is a Group IVB transition metal halide.

Abstract: 3,5-Bis(trifluoromethyl)benzoyl chlorides optionally substituted with fluorine or chlorine are advantageously prepared by converting 3,5-dimethylbenzoic acids optionally substituted with fluorine or chlorine into the corresponding acid chlorides; completely free-radically chlorinating said chlorides in the side chains, giving 3,5-bis(trichloromethyl)benzoyl chlorides optionally substituted by fluorine or chlorine; fluorinating the latter with anhydrous hydrogen fluoride and/or antimony pentafluoride, giving 3,5-bis(trifluoromethyl)benzoyl fluorides optionally substituted with fluorine or chlorine; and then reacting the 3,5-bis(trifluoromethyl)benzoyl fluorides with silicon tetrachloride in the presence of a further Lewis acid. Some of the 3,5-bis(trihalogenomethyl) and 3,5-dimethylbenzoyl halides which arise as intermediates are novel compounds.

Abstract: The present invention provides process for the preparation of chlorocarbonyl chlorides of the formula I R1—CHCl—Y—COCl  (I), where R1 is for example hydrogen or C1- to C20-alkyl and Y is for example a saturated or mono- or polyolefinically unsaturated C2-C8-alkylene chain, by reacting lactones with a chlorinating agent in the presence of a urea compound.

Abstract: A nucleophilic substitution reaction on optionally substituted dihalobenzenes is carried out in the presence of an optional catalyst followed by formation of and subsequent carboxylation of a Grignard reaction intermediate. In particular the present invention provides a process leading to optionally substituted hydroxybenzoic, alkanoyloxybenzoic, formyloxybenzoic and alkoxybenzoic acids from 1-substituted 2,6-dihalobenzenes. The invention also provides a process for the direct formation of an acyl chloride from a Grignard reagent by quenching with phosgene.

Abstract: Process for the phosgenation of monocarboxylic acids and/or anhydrides, characterized in that the acid and/or the anhydride is treated, in the presence or absence of solvent, with a molar excess of phosgene, preferably 2 to 15 times as much phosgene as acid, at temperatures between 80 and 200.degree. C. and at pressures between 2 and 60 bar, with or without catalyst, preferably in the absence of any catalyst.Process furthermore characterized in that pressure is used to facilitate the separation of the hydrochloric acid, the carbon dioxide and the phosgene, in a column which is external to the reactor.

Abstract: A method for preparing fatty acid chlorides. The method comprises reacting a silylation product of a fatty acid comprising at 1east 2 aliphatically unsaturated bonds per molecule and a chlorinating agent.

Abstract: Phosgenation of carboxylic acids to the corresponding carboxylic acid chlorides in conducted in the presence of a solvent comprising acetonitrile.

Abstract: A preparation process of acyl halide or sulfonyl halide which comprises reacting corresponding carboxylic acid or sulfonic acid with a haloiminium salt represented by the general formula (1): ##STR1## wherein R.sup.1 and R.sup.2 are same or different lower alkyl groups, X is a halogen atom, and n is an integer of 2 or 3.

Abstract: A process for the preparation of .alpha.,.beta.-unsaturated .beta.-oxycarboxylic acid chlorides of the formula I ##STR1## where R.sup.1 is a C-organic radical, and R.sup.2 and R.sup.3, independently of one another, are hydrogen or a C-organic radical, comprises carrying out the addition reaction of an enol derivative of the formula II ##STR2## with a compound of the formula IIIa, IIIb or IIIc ##STR3## and converting the resultant acid chloride of the formula ##STR4## into I by elimination of hydrogen chloride (HCl).

Abstract: A process for the continuous manufacture of carboxylic chlorides (I) of the general formula R-COCl, in which R stands for a C-organic radical containing from 1 to 30 C atoms, by the reaction of a carboxylic acid (II) with a reaction product (III) of phosgene (IV) and an N,N-substituted formamide (V), in which compounds II and III are passed in parallel flow upwardly into a zone, filled with compound III, in a reactor (1), the reaction mixture is allowed to rise in predominantly laminar flow, such that phase separation occurs to give a top I-phase and a bottom phase III' mainly comprising compound III and formamide formed and compound I is removed from the top phase and also portions of the bottom phase III' are removed at the rate at which they are formed.

Abstract: Disclosed is a process for producing a carboxylic acid chloride by reacting phosgene with a carboxylic acid or an anhydride thereof, which comprises effecting the reaction in the presence of a homopolymer or copolymer of a monomer represented by formula (I) or (II) below, a copolymer of the monomers represented by formulae (I) and (II) below, or a copolymer of at least one monomer selected from the group sensisting of the monomers represented by formulae (I) and (II) below with another monomer copolymerizable therewith:CH.sub.2 .dbd.CHNR.sup.1 COR.sup.2 (I)CH.sub.2 .dbd.CR.sup.3 CONR.sup.4 R.sup.5 (II).In these formulae R.sup.1, R.sup.2, and R.sup.4 each represents an alkyl group containing from 1 to 3 carbon atoms, or an alkylene group containing from 3 to 5 carbon atoms provided that R.sup.1 with R.sup.2, and R.sup.4 with R.sup.5 may each combine to form a ring structure through >N--CO-- or >N-- in the molecule; R.sup.3 and R.sup.

Abstract: A process for the preparation of a carboxylic chloride of the general formula I ##STR1## in which R denotes C.sub.1 -C.sub.30 -alkyl, C.sub.2 -C.sub.30 -alkenyl or C.sub.2 -C.sub.30 -alkynyl, from a carboxylic acid of the general formula II ##STR2## in which R has the meanings stated, and phosgene COCl.sub.2 (III), in the presence of a catalyst adduct comprising phosgene and N,N-disubstituted formamide of the general formula IV ##STR3## in which R.sup.1 and R.sup.2 are independently C.sub.1 -C.sub.3 -alkyl or R.sup.1 and R.sup.2 together form a C.sub.4 - or C.sub.5 -alkylene chain which may or may not be interrupted by an oxygen atom or by a nitrogen atom carrying a C.sub.1 -C.sub.3 -alkyl group or CHO, the product being isolated by phase separation, wherein the amount of phosgene added to the formamide (IV) is from 20 to 70% molar, based on the formamide.

Abstract: Acyl chlorides of the general formula ##STR1## where R is C.sub.8 -C.sub.30 -alkyl, C.sub.8 -C.sub.30 -alkenyl or C.sub.8 -C.sub.30 -alkynyl, are prepared from a carboxylic acid of the general formula II ##STR2## where R has the abovementioned meanings, and phosgene, COCl.sub.2 (III), in the presence of a catalyst adduct of phosgene and N,N-dialkylformamide of the general formula IV ##STR3## where R.sup.1 and R.sup.2 independently of one another are each C.sub.1 -C.sub.3 -alkyl, preferably a 1:1 adduct in excess N,N-dialkylformamide, the reaction product I being obtained by phase separation, by a process in which II and III are used in essentially equimolar amounts and the phase containing the catalyst adduct is reused.

Abstract: The invention relates to a process for the preparation of chlorides of chlorinated carboxylic acids of formula ##STR1## in which R.sup.2 denotes the radical (CH.sub.2).sub.n, n being an integer from 2 to 4, or the radical --CH.sub.2 --C(C.sub.6 H.sub.5).sub.2 -- and R.sup.1 denotes a hydrogen atom or an alkyl radical containing from 1 to 4 carbon atoms, which consists in reacting the lactones of formula ##STR2## in which R.sup.1 and R.sup.2 have the above meanings, with phosgene at a temperature of 90.degree. to 180.degree. C., while employing as catalysts trisubstituted phosphine oxides or sulphides.The process according to the invention makes it possible to obtain chlorides of chlorinated carboxylic acids of high purity which exhibit an excellent stability to light and to heat and which are very useful as synthesis intermediates.

Abstract: Novel fluorine-containing compounds and processes for producing the same are disclosed, the compounds being represented by the general formula (I): ##STR1## wherein R.sup.1 represents an alkyl group or an alkylvinyl group; R.sup.2 represents a fluoroalkyl group; and Y represents a carboxyl group, a chloroformyl group, an alkoxyalkoxycarbonyl group or a hydroxymethyl group.

Abstract: The present invention relates to improved processes for selectively chlorinating acyl compounds at the alpha or 2-position. The process of the present invention comprises a method of producing alpha-chloro acyl chlorides comprising contacting an acyl chloride with a chlorine source at a temperature of about 75.degree. C. to about 125.degree. C. in the presence of (i) an effective amount of an auxiliary acidic agent and (ii) an effective amount of a food grade antioxidant and optionally (iii) an effective amount of oxygen or air.

Abstract: An N-alkylated formamide of the formula ##STR1## wherein R.sup.1 denotes alkylR.sup.2 denotes alkyl with at least 9 carbon atoms or the group ##STR2## wherein A denotes straight-chain or branched alkanediyl,R.sup.1 denotes lower alkyl andn denotes an integer from 2 to 6,a process for the preparation of the same and its use in the replacement of a hydroxyl group in an organic compound by chlorine or bromine the improvement wherein the replacement is carried out in the presence of an N-alkylated formamide.