Containing -c(=x)-nh-x-c(=x)- Or -c(=x)-nh-x-s(=o)(=o)-, Wherein Substitution May Be Made For Hydrogen Only, And The X's May Be The Same Or Diverse Chalcogens Patents (Class 562/874)
  • Patent number: 8507722
    Abstract: Hepatitis C virus inhibitors are disclosed having the general formula: wherein R1, R2, R3, R?, B, Y and X are described in the description. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
    Type: Grant
    Filed: August 29, 2012
    Date of Patent: August 13, 2013
    Assignee: Bristol-Myers Squibb Company
    Inventor: Alan Xiangdong Wang
  • Patent number: 5874459
    Abstract: Disclosed is a method of inhibiting anandamide amidase in an individual or animal and novel inhibitors of anandamide amidase. The disclosed method and novel compounds can be used to reduce pain in an individual or animal suffering from pain, reducing nausea in an individual undergoing chemotherapy, for example cancer chemotherapy, suppressing appetite in an individual, reducing intraocular pressure in the eye of an individual or animal suffering from glaucoma and suppressing the immune system in an individual with an organ transplant.
    Type: Grant
    Filed: November 12, 1997
    Date of Patent: February 23, 1999
    Assignee: University of Connecticut
    Inventors: Alexandros Makriyannis, Sonyan Lin, William Adam Hill
  • Patent number: 5856560
    Abstract: A process and intermediates for preparing .alpha.
    Type: Grant
    Filed: December 10, 1996
    Date of Patent: January 5, 1999
    Assignee: BASF Aktiengesellschaft
    Inventors: Herbert Bayer, Heinz Isak, Horst Wingert, Hubert Sauter, Michael Keil, Markus Nett, Remy Benoit, Ruth Muller
  • Patent number: 5804601
    Abstract: The present invention relates to a compound of the formula: ##STR1## wherein Ar represents an optionally substituted aromatic group; Q represents a divalent aliphatic hydrocarbon group; R.sub.1 represents hydrogen, cyano, an optionally substituted hydrocarbon group, a group of the formula: ##STR2## wherein R.sup.3 and R.sub.4 independently represent hydrogen, acyl or an optionally substituted hydrocarbon group, or R.sup.3 and R.sup.4 jointly form a ring, or acyl; R.sup.2 represents acyl; ......... represents a single bond or a double bond; m represents 1 or 2 or a salt, a process of producing thereof and an anti-neurodegenerative composition.
    Type: Grant
    Filed: April 9, 1996
    Date of Patent: September 8, 1998
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Kaneyoshi Kato, Shokyo Miki, Ken-ichi Naruo, Hideki Takahashi
  • Patent number: 5663433
    Abstract: Process for the preparation of N-alkyl-N,O-diacetyl hydroxylamine, for instance N-methyl-N,O-diacetyl hydroxylamine, by catalytic reduction of a nitroalkane, for instance nitromethane, in the presence of acetic anhydride. As catalyst preferably a platinum on alumina catalyst is used. The invention provides a simple one-step process for the preparation of N-alkyl-N,O-diacetyl hydroxylamine in a relatively concentrated reaction medium.
    Type: Grant
    Filed: June 17, 1996
    Date of Patent: September 2, 1997
    Assignee: DSM N.V.
    Inventors: Anna M. C. F. Castelijns, Joannes M. C. A. Mulders
  • Patent number: 5416078
    Abstract: The invention relates to fluid resuscitation of the human or animal body by administration of deferoxamine (DFO) and a water-soluble biopolymer.The DFO and the biopolymer are preferably bonded together.The biopolymer may be a polysaccharide or a protein.The DFO and the biopolymer are preferably formulated as an aqueous solution suitable for oral administration.The fluid resuscitation may be effected for ameliorating systemic oxidant injury occurring during ischemia and subsequent reperfusion.The fluid resuscitation may be indicated in treatment of burn injury, lung injury caused by inhalation of hot and/or toxic substances, such as smoke derived from combustion, hemorrhagic shock and other types of trauma.
    Type: Grant
    Filed: November 25, 1992
    Date of Patent: May 16, 1995
    Assignee: Biomedical Frontiers, Inc.
    Inventors: Bo E. Hedlund, Philip E. Hallaway
  • Patent number: 5371264
    Abstract: Describes a process for preparing N,O-disubstituted hydroxylamine compounds comprising reacting an aqueous solution of free hydroxylamine with an equimolar amount of a carbonyl halide-containing compound, e.g., a chloroformate such as phenyl chloroformate, in the presence of a substantially stoichiometric amount of a weak inorganic basic reagent, thereby to produce the N-substituted derivative, and thereafter further reacting an inert organic solvent solution of the N-substituted derivative with an equimolar amount of the corresponding carbonyl halide-containing compound in the presence of a substantially stoichiometric amount of weak inorganic basic reagent, thereby to produce the N,O-disubstituted derivative, e.g., N,O-bis(phenoxycarbonyl) hydroxylamine. In a preferred embodiment, the organic solvent is used also in the reaction that produces the N-substituted derivative. N,O-disubstituted hydroxylamine compounds containing less than 3 weight percent, e.g., less than 0.
    Type: Grant
    Filed: January 27, 1993
    Date of Patent: December 6, 1994
    Assignee: PPG Industries, Inc.
    Inventors: James A. Manner, Suresh B. Damle
  • Patent number: 5342980
    Abstract: There are provided hydroxamic acids, and the esters and chelates thereof having the structure ##STR1## and their use for the prevention, control or amelioration of diseases caused by phytopathogenic fungi. Further provided are compositions and methods comprising those compounds for the protection of plants from fungal infestation and disease.
    Type: Grant
    Filed: December 30, 1992
    Date of Patent: August 30, 1994
    Assignee: American Cyanamid Company
    Inventor: Gregory J. Haley
  • Patent number: 5187192
    Abstract: Compounds of the structure ##STR1## where M is a pharmaceutically acceptable cation or a metabolically cleavable group, R is alkyl, cycloalkyl or --NR.sup.1 R.sup.2, where R.sup.1 and R.sup.2 are hydrogen, alkyl, cycloalkyl or alkanoyl, and A is optionally substituted alkyl, cycloalkyl, carbocyclic aryl, benzo[b]furyl, thienyl, or benzo[b]thienyl are potent inhibitors of lipoxygenase enzymes and thus inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.
    Type: Grant
    Filed: March 13, 1992
    Date of Patent: February 16, 1993
    Assignee: Abbott Laboratories
    Inventors: Dee W. Brooks, Karen E. Rodriques
  • Patent number: 5140047
    Abstract: Tricyclic hydroxyurea and hydroxamate compounds, pharmaceutical compositions, and their use as as inhibitors of the oxidation of polyunsaturated fatty acids, such as by inhibition on the 5-lipoxygenase enzyme, and treatment of diseases therein.
    Type: Grant
    Filed: May 3, 1991
    Date of Patent: August 18, 1992
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry L. Adams, Ravi S. Garigipati
  • Patent number: 5130479
    Abstract: The solution pertains to hydrolytically degradable hydrophilic gels consisting of the individual chains of hydrophilic polymer interconnected with crosslinks containing the structure unit ##STR1## The method for preparation of the hydrolytically degradable gels consists in subjecting hydrophilic monomers or their mixture to the radical polymerization or copolymerization, or to copolymerization with hydrophobic monomers, in the presence of a new compound--N,O-dimethacryloylhydroxylamine--as a crosslinking agent, and, if desired, in the presence of a solvent, whereas the amount of hydrophilic monomers is 50 to 99.8 molar percent related to all monomers present.
    Type: Grant
    Filed: December 10, 1991
    Date of Patent: July 14, 1992
    Assignee: Ceskoslovenska Akademie Ved
    Inventors: Karel Ulbrich, Vladimir Subr
  • Patent number: 5124480
    Abstract: The present invention relates to N,O-diacyl,N-acyl hydroxylamines and their use as bleach activators in conjunction with oxygen-releasing compounds.
    Type: Grant
    Filed: October 10, 1989
    Date of Patent: June 23, 1992
    Assignee: Monsanto Company
    Inventor: James P. Coleman
  • Patent number: 4897422
    Abstract: Compounds of the formula: ##STR1## where R.sub.1 is amino or methyl; R.sub.2 is C.sub.1 -C.sub.2 alkyl; R.sub.3 is one or more substituents selected from hydrogen, halogen or trihalomethyl; R.sub.4 is one or more substituents selected from hydrogen, halogen, trihalomethyl, C.sub.1 to C.sub.4 alkoxy or C.sub.1 to C.sub.4 alkyl; and M is hydrogen, a pharmaceutically acceptable cation, aroyl, or C.sub.1 to C.sub.6 alkoyl are inhibitors of 5- and/or 12-lipoxygenase enzymes.
    Type: Grant
    Filed: February 10, 1987
    Date of Patent: January 30, 1990
    Assignee: Abbott Laboratories
    Inventor: James B. Summers, Jr.