Adducts Or Inclusion Compounds Of Urea Per Se Or Of Of Thiourea Per Se With Organic Compounds (e.g., Urea-alkane Inclusion Compounds, Etc.) Patents (Class 564/1.5)
  • Patent number: 9297587
    Abstract: In an adsorption heat exchanger, adsorbent expanded by absorbing moisture and contracted by dissipating moisture is supported on a surface of a heat exchanger body. An adsorbent layer containing the adsorbent is formed on the surface of the heat exchanger body by applying slurry containing the adsorbent in a contracted state to the surface of the heat exchanger body and drying the slurry. A solvent of the slurry contains alcohol as a main component.
    Type: Grant
    Filed: May 17, 2010
    Date of Patent: March 29, 2016
    Inventors: Takahisa Sueoka, Hirohiko Matsushita, Shuuji Ikegami, Lan Jiang
  • Patent number: 9029590
    Abstract: The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that demonstrates enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver. The present invention employs low molecular weight cationic lipids comprising at least one short lipid chain to enhance the efficiency and tolerability of in vivo delivery of siRNA.
    Type: Grant
    Filed: October 17, 2011
    Date of Patent: May 12, 2015
    Assignee: SIRNA Therapeutics, Inc.
    Inventors: Steven L. Colletti, Matthew G. Stanton
  • Patent number: 8466200
    Abstract: The present invention relates to 2-adamantylurea derivatives of formula I as selective inhibitors of the enzyme 11-beta-hydroxysteroid dehydrogenase type 1 (11?-HSD1) and the use of such compounds for the treatment and prevention of metabolic syndrome, diabetes, insulin resistance, obesity, lipid disorders, glaucoma, osteoporosis, cognitive disorders, anxiety, depression, immune disorders, hypertension and other diseases and conditions.
    Type: Grant
    Filed: February 7, 2012
    Date of Patent: June 18, 2013
    Assignee: Merck Patent GmbH
    Inventors: Denis Carniato, Christine Charon, Johannes Gleitz, Didier Roche, Bjoern Hock
  • Patent number: 7145046
    Abstract: Inorganic and organic compounds containing fluorine can be produced, for example, from corresponding chlorine-containing compounds by chlorine/fluorine exchange using fluorinating agents. Monocyclic or bicyclic compounds containing at least two nitrogen atoms, at least one of which is incorporated into the ring system, can be used as catalysts or fluorinating agents for chlorine/fluorine exchange reactions to produce sulfurylchlorofluoride, sulfurylfluoride or a carboxylic acid fluoride. It is likewise possible to carry out HF addition to unsaturated carbon-carbon bonds or chlorine/fluorine exchange at carbon atoms. For example, monochloro or dichloro malonic acid esters can be converted to difluoro malonic acid esters. Work-up of the reaction mixture can be simplified by using suitable solvents which force the reaction mixture to exist in two phases.
    Type: Grant
    Filed: August 1, 2003
    Date of Patent: December 5, 2006
    Assignee: Solvay Fluor und Derivate GmbH
    Inventors: Max Braun, Carsten Brosch
  • Patent number: 7002041
    Abstract: An amide composition containing an unsaturated amide, a sulfur-containing compound, and a weak acid salt. The composition can include an amide in crystalline form or the composition can be in form of aqueous solution. The composition can exhibit improved stability whereby polymerization of the amide is inhibited.
    Type: Grant
    Filed: November 4, 2002
    Date of Patent: February 21, 2006
    Assignee: Mitsui Chemicals, Inc.
    Inventors: Takeya Abe, Kenju Sasaki
  • Patent number: 6774270
    Abstract: A method of removing hexafluoropropylene dimers (“HFP dimers”), dimer hydrides and other oligomers from a fluid is described. The method comprises heating the fluid to isomerize the HFP dimers to the thermodynamic isomer, and contacting the fluid with a tertiary amine (or salts thereof) to form a hexafluoropropylene dimer—tertiary amine adduct. The method may further comprise the step of separating the dimer adducts from the reaction mixture.
    Type: Grant
    Filed: April 1, 2003
    Date of Patent: August 10, 2004
    Assignee: 3M Innovative Properties Company
    Inventors: Zhongxing Zhang, Zai-Ming Qiu, Daniel R. Vitcak, Richard M. Flynn
  • Patent number: 6284921
    Abstract: An oligomethylene urea product usable as a fertilizer can be more efficiently prepared in several steps by: a) introducing at least urea and an aqueous solution of formaldehyde in the overall molar ratio of urea to formaldehyde of the step 1:1-2:1 into a reactor with a retention time of at least 0.5 h, a temperature maintained in the range of 40 to 95° C. and a pH maintained in the range of 6.5 to 11, in order to produce a methylol urea composition, b) conducting the methylol urea composition to a second reactor with a temperature maintained in the range of 5 to 35° C. and a pH maintained in the range of 1.8 to 3.5, in order to produce a first oligomethylene urea slurry, and optionally, c) conducting the methylol urea composition or the first oligomethylene urea slurry to a third reactor with a temperature maintained in the range of 5 to 35° C. and a pH maintained in the range of 1.8 to 3.
    Type: Grant
    Filed: January 28, 1998
    Date of Patent: September 4, 2001
    Assignee: Kemira Agro Oy
    Inventor: Jarmo Luhtala