Benzene Ring Containing Patents (Class 564/105)
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Patent number: 8748015Abstract: An indenofluorenedione derivative having a specific structure, which is useful as a material for organic electroluminescence devices because the derivative is excellent in heat resistance and can be vapor-deposited on a substrate at moderate temperature. An organic electroluminescence device including an anode, a cathode, and an organic thin layer between the anode and the cathode, which contains the material for organic electroluminescence devices in the organic thin layer, is driven at a low driving voltage and has a long lifetime.Type: GrantFiled: September 3, 2013Date of Patent: June 10, 2014Assignee: Idemitsu Kosan Co., Ltd.Inventors: Hironobu Morishita, Yuichiro Kawamura, Jun Endo
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Publication number: 20140001461Abstract: An indenofluorenedione derivative having a specific structure, which is useful as a material for organic electroluminescence devices because the derivative is excellent in heat resistance and can be vapor-deposited on a substrate at moderate temperature. An organic electroluminescence device including an anode, a cathode, and an organic thin layer between the anode and the cathode, which contains the material for organic electroluminescence devices in the organic thin layer, is driven at a low driving voltage and has a long lifetime.Type: ApplicationFiled: September 3, 2013Publication date: January 2, 2014Applicant: IDEMITSU KOSAN CO., LTD.Inventors: Hironobu Morishita, Yuichiro Kawamura, Jun Endo
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Patent number: 8288013Abstract: A material for an organic electroluminescence device including an indenofluorenedione derivative shown by the following formula (I): wherein X1 and X2, which may be the same or different, are any of specific divalent groups; R1 to R10, which may be the same or different, are a hydrogen atom, an alkyl group, an aryl group, a heterocycle, a halogen atom, a fluoroalkyl group, an alkoxy group, an aryloxy group or a cyano group; and R3 to R6 or R7 to R10 may be bonded to each other to form a ring.Type: GrantFiled: July 14, 2008Date of Patent: October 16, 2012Assignee: Idemitsu Kosan Co., Ltd.Inventor: Hironobu Morishita
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Patent number: 8119828Abstract: A material for an organic electroluminescence device represented by the following formula (I): wherein X1 is one of divalent groups represented by the following (a) to (e); Y1 to Y4 are independently a carbon atom or a nitrogen atom; and R1 to R4 are independently a hydrogen atom, an alkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted heterocycle, a halogen atom, a fluoroalkyl group or a cyano group, or R1 and R2, and R3 and R4 are independently bonded to form a substituted or unsubstituted aromatic ring or a substituted or unsubstituted heterocycle.Type: GrantFiled: December 10, 2007Date of Patent: February 21, 2012Assignee: Idemitsu Kosan Co., Ltd.Inventor: Hironobu Morishita
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Publication number: 20100240713Abstract: This invention is directed to compounds of formula (I), wherein m, formula (II), R1, R2 and R3 are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, for the treatment of iron disorders. This invention is also directed to pharmaceutical compositions comprising the compounds and methods of using the compounds to treat iron disorders.Type: ApplicationFiled: June 5, 2008Publication date: September 23, 2010Applicant: XENON PHARMACEUTICALS INC.Inventors: Jean-Jacques Cadieux, Mikhail Chafeev, Julia Fonarev, Jianmin Fu, Rajender Kamboj, Vishnumurthy Kodumuru, Serguei Sviridov, Zaihui Zhang
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Publication number: 20100044686Abstract: A material for an organic electroluminescence device represented by the following formula (I): wherein X1 is one of divalent groups represented by the following (a) to (e); Y1 to Y4 are independently a carbon atom or a nitrogen atom; and R1 to R4 are independently a hydrogen atom, an alkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted heterocycle, a halogen atom, a fluoroalkyl group or a cyano group, or R1 and R2, and R3 and R4 are independently bonded to form a substituted or unsubstituted aromatic ring or a substituted or unsubstituted heterocycle.Type: ApplicationFiled: December 10, 2007Publication date: February 25, 2010Applicant: IDEMITSU KOSAN CO., LTD.Inventor: Hironobu Morishita
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Publication number: 20100019659Abstract: A material for an organic electroluminescence device including an indenofluorenedione derivative shown by the following formula (I): wherein X1 and X2, which may be the same or different, are any of specific divalent groups; R1 to R10, which may be the same or different, are a hydrogen atom, an alkyl group, an aryl group, a heterocycle, a halogen atom, a fluoroalkyl group, an alkoxy group, an aryloxy group or a cyano group; and R3 to R6 or R7 to R10 may be bonded to each other to form a ring.Type: ApplicationFiled: July 14, 2008Publication date: January 28, 2010Applicant: Idemitsu Kosan Co., LtdInventor: Hironobu Morishita
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Patent number: 6878706Abstract: Compounds according to the following formula (I): wherein the variables Q and R1 to R6 are as described herein, which reversibly inhibit the cysteine proteases, such as cathepsins K, S, F, L and B; pharmaceutical compositions containing such compounds, and method of treating diseases and pathological conditions exacerbated by these cysteine proteases such as, but not limited to rheumatoid arthritis, multiple sclerosis and other autoimmune diseases, osteoporosis, asthma, Alzheimer's disease, atherosclerosis and endometriosis.Type: GrantFiled: March 27, 2003Date of Patent: April 12, 2005Assignee: Boehringer Ingelheim Pharmaceuticals Inc.Inventors: Thomas A. Gilmore, Eugene Richard Hickey, Weimin Liu, Peter Allen Nemoto, Denice M. Spero
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Patent number: 6638979Abstract: The present invention relates to novel imidamide derivatives of the formula (I) in which R, R1, R2 and R3 are each as defined in the description, to a process for their preparation and to their use for controlling animal pests, such as insects, arachnids and, in particular, nematodes.Type: GrantFiled: February 5, 2001Date of Patent: October 28, 2003Assignee: Bayer AktiengesellschaftInventors: Hans-Jochem Riebel, Peter Gerdes, Ernst-Rudolf F. Gesing, Achim Hense, Johannes Kanellakopulos, Kristian Kather, Rolf Kirsten, Stefan Lehr, Lothar Rohe, Katharina Voigt, Detleff Wollweber, Wolfram Andersch
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Patent number: 6359061Abstract: Amide compounds of formula (I), combinatorial libraries of amide compounds and methods of preparing the same are provided. Libraries of the invention are useful for screening in biological assays in order to identify pharmaceutically useful compounds.Type: GrantFiled: March 19, 1999Date of Patent: March 19, 2002Assignee: ISIS Pharmaceuticals, Inc.Inventors: Eric Edward Swayze, Peter William Davis
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Patent number: 6194464Abstract: The present invention relates to new imidic acid derivatives of the formula (I) to a plurality of processes for their preparation, and to their use as pesticides.Type: GrantFiled: April 28, 1999Date of Patent: February 27, 2001Assignee: Bayer AktiengesellschaftInventors: Dietmar Kuhnt, Ulrich Heinemann, Herbert Gayer, Peter Gerdes, Jörg Stetter, Ralf Tiemann, Klaus Stenzel, Stefan Dutzmann
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Patent number: 6143775Abstract: The invention provides a pharmaceutical composition comprising a particular physical form of N-[4-[5-(cyclopentyloxy-carbonyl)amino-1-methylindol-3-yl-methyl]-3-methox ybenzoyl]-2-methyl-benzenesulphonamide and polyvinylpyrrolidone. It also provides methods for preparing this physical form, and another physical form of N-[4-[5-(cyclopentyloxycarbonyl)amino-1-methylindol-3-yl-methyl]-3-methoxy benzoyl]-2-methylbenzenesulphonamide useful in the preparation of the first mentioned physical form. The compositions are useful in the treatment of diseases in which leukotrienes are implicated, for example asthma.Type: GrantFiled: November 23, 1999Date of Patent: November 7, 2000Assignee: Zeneca LimitedInventors: James Joseph Holohan, Ieuan John Edwards
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Patent number: 6069275Abstract: A novel monomer composition for promoting wet adhesion of latex polymers for paints is provided. The composition consists essentially of a monomer having the formula: ##STR1## The preferred monomer is derived from the reaction of hydroxyethyl methacrylate with isophorone diisocyanate followed by reaction of the monourethane product the N-aminoethyl ethylene urea. The monomer is preferably copolymerized in an emulsion polymerization with acrylic and/or vinyl monomers.Type: GrantFiled: January 28, 1998Date of Patent: May 30, 2000Assignee: Rhodia Inc.Inventors: Norman Shachat, Zenyk Kosarych
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Patent number: 5892111Abstract: A cure-accelerator for an epoxy resin, which comprises a compound of the formula (I),R.sub.1 R.sub.2 NCONH--Ar--NECONR.sub.3 R.sub.4 (I)wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are C.sub.1 -C.sub.3 lower alkyl groups which may be the same or different, and Ar is a substituted tolylene group of the formula (II) ##STR1## (wherein R.sub.5 and R.sub.6 are C.sub.1 -C.sub.4 lower alkyl groups which may be the same or different) or a 1,5-naphthylene group.Type: GrantFiled: September 8, 1997Date of Patent: April 6, 1999Assignee: Hodogaya Chemical Co., Ltd.Inventor: Susumu Jinbo
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Patent number: 5719320Abstract: A cure-accelerator for an epoxy resin, which comprises a compound of the formula (I),R.sub.1 R.sub.2 NCONH--Ar--NHCONR.sub.3 R.sub.4 (I)wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are C.sub.1 -C.sub.3 lower alkyl groups which may be the same or different, and Ar is a substituted tolylene group of the formula (II) ##STR1## wherein R.sub.5 and R.sub.6 are C.sub.1 -C.sub.4 lower alkyl groups which may be the same or different) or a 1,5-naphthylene group.Type: GrantFiled: April 8, 1996Date of Patent: February 17, 1998Assignee: Hodogaya Chemical Co., Ltd.Inventor: Susumu Jinbo
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Patent number: 5684196Abstract: There is disclosed a process of producing a 2-iminothiazoline derivative of the general formula ?II!, characterized in that a thiourea derivative of the general formula ?I! is treated with an acid. Also disclosed are a process of producing an N-substituted N-arylcyanamide derivative of the general formula ?VI!, characterized in that an N-arylcyanamide derivative of the general formula ?IV! is reacted with an allyl halide derivative of the general formula ?V! in an aprotic polar solvent in the presence of an iodide and an alkali metal carbonate; and a process of producing an N-substituted N-arylthiourea derivative of the general formula ?VII!, characterized in that an N-substituted N-arylcyanamide derivative of the general formula ?VI! obtained as described above is further reacted with a chemical species which generates sulfide ion or hydrogensulfide ion.Type: GrantFiled: June 6, 1996Date of Patent: November 4, 1997Assignee: Sumitomo Chemical Co., Ltd.Inventors: Katuhisa Masumoto, Toshio Nagatomi, Akihiko Nakamura, Yoshimi Yamada
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Patent number: 5594033Abstract: Novel secoaporphine compounds having the formula I ##STR1## wherein a) R.sub.1, R.sub.2 and R.sub.3, R.sub.4 are each methyl group; or b) R.sub.1, R.sub.2, and R.sub.4 are each methyl group; R.sub.3 is benzyl, ethyl or allyl; or c) R.sub.1, R.sub.2, and R.sub.3 are each hydrogen, R.sub.4 is methyl; or d) R.sub.1 and R.sub.2 are each hydrogen, R.sub.3 is benzyl, R.sub.4 is methyl; or e) R.sub.1 and R.sub.2 are each hydrogen, R.sub.3 is cyano, R.sub.4 is methyl group, and a salt thereof with a pharmaceutically acceptable acid. The novel compounds are useful in the treatment of arrhythmia.Type: GrantFiled: January 26, 1994Date of Patent: January 14, 1997Assignee: National Science CouncilInventors: Ming-Jai Su, Che-Ming Teng, Shoei-Sheng Lee
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Patent number: 5382595Abstract: A butenoic or propenoic acid derivative having the following formula in which G is an aryl or a heterocyclic ring, R11 and R12 are hydroben or an alkyl, X is sulfur or oxygen, R2 and R3 are hydrogen, an substituent such as an alkyl and J is pyridyl or phenyl having substituents and a heterocyclic ring may be formed between R2, R3 and J is provided here and is useful in the pharmacological field.Type: GrantFiled: October 13, 1992Date of Patent: January 17, 1995Assignee: Eisai Co., Ltd.Inventors: Norio Minami, Fumihiro Ozaki, Keiji Ishibashi, Yasuhiro Kabasawa, Megumi Ikemori, Toshiaki Ogawa, Takanori Kawamura
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Patent number: 5175365Abstract: There are provided novel nitroguanidine and cyanoguanidine compounds. A method of dessicating and defoliating plants by applying to the foliage thereof certain nitroguanidine or cyanoguanidine compounds and a method for the selective preemergence control of undesirable broadleaf weeds and grasses in the presence of graminaceous crops are disclosed.Type: GrantFiled: June 14, 1991Date of Patent: December 29, 1992Assignee: American Cyanamid CompanyInventors: Robert L. Arotin, Bryant L. Walworth, Michele E. Marini
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Patent number: 5166402Abstract: Herbicidal .alpha.-(5-aryloxy-naphthalen-1-yl-oxy)propionic acid derivatives of the formula ##STR1## in which R.sup.1 stands for hydrogen, halogen, cyano or trifluoromethyl,R.sup.2 stands for hydrogen or halogen,R.sup.3 stands for halogen, cyano, trifluoromethyl or trifluoromethoxy,R.sup.4 stands for hydrogen or halogen,R.sup.5 stands for hydrogen or halogen andZ stands for halogen, hydroxyl, amino, alkylamino, alkenylamino, alkinylamino, arylamino, aralkylamino, alkoxycarbonylalkylamino, cyanamino, dialkylamino, dialkenylamino, alkylsulphonylamino, arylsulphonylamino, hydroxylamino, alkoxyamino, hydrazino, alkylsulphonylhydrazino, arylsulphonylhydrazino, alkylthio, arylthio, aralkylthio, alkoxycarbonylalkylthio or for the --O--R.sup.6 group,wherein R.sup.6 can be various organic radicals.The starting material naphthol of the formula ##STR2## is also new.Type: GrantFiled: November 1, 1990Date of Patent: November 24, 1992Assignee: Bayer AktiengesellschaftInventors: Michael Haug, Hans-Joachim Santel, Robert R. Schmidt, Harry Strang
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Patent number: 5118813Abstract: For the preparation of compounds such as ranitidine, niperotidine and cimetidine a urea of the formula:R.sub.1 --NH--C--NH--(CH.sub.2).sub.n --SD--S--(CH.sub.2).sub.n --NH--C--NH--R.sub.1 (I)which is synthesized by reaction with a compound of formula ##STR1##[H.sub.2 N--(CH.sub.2).sub.n --S--] (IX)is converted in a first stage into the corresponding bis-carbodiimideR.sub.1 --N.dbd.C.dbd.N--(CH.sub.2).sub.n --S--S--(CH.sub.2).sub.n --N.dbd.C.dbd.N--R.sub.1 (II)by reaction with triphenylphospine and bromine in the presence of a strong base and in a second stage the diimide thus obtained is reacted with nitromethane or a saline derivative of the cyanamide.The product thus obtained is reduced at the disulfide bridge obtaining a compound of formula: ##STR2## which is reacted with: ##STR3## to obtain ranitidine and niperotidine or cimetidine respectively depending on whether the first or the second of the described reactants is used.Type: GrantFiled: October 16, 1990Date of Patent: June 2, 1992Assignee: Biote kfarma SrlInventor: Alberto Reiner
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Patent number: 5103021Abstract: Carbonyl derivatives of acetaminophen are provided for use in homogeneous enzyme immunoassays for acetaminophen. The derivatives are conjugated to antigenic substances for the preparation of antisera specific to acetaminophen, and to enzymes for the preparation of enzyme conjugates which compete with acetaminophen for antibody binding sites in a typical assay.Type: GrantFiled: July 30, 1987Date of Patent: April 7, 1992Assignee: Syntex (U.S.A.) Inc.Inventor: Pyare Khanna
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Patent number: 5024691Abstract: As new compounds, substituted aryloxyphenoxy benzamides having the formula ##STR1## in which X is CH or nitrogen; Y is chlorine, bromine, fluorine, iodine, methyl, cyano or hydrogen; Z is hydrogen, chlorine, bromine, fluorine, iodine, CH.sub.n, F.sub.3-n where n is an integer from 0 to 3; R is nitrogen dioxide, hydrogen or halogen; R' is hydrogen, CH.sub.3, lower alkyl, having 1-10 carbon atoms, SCCl.sub.3, ##STR2## or --PO.sub.3 R.sup.3.sub.2 wherein R.sup.3 is hydrogen, alkyl having 1-10 carbon atoms, aryl, or an equivalent of base such as a salt; R" is cyano, --C.tbd.CH, ##STR3## wherein R.sup.4 is hydrogen, alkyl having 1-10 carbon atoms, aryl or an equivalent of base such as a salt; and m is 0, 1, 2 or 3.Type: GrantFiled: August 4, 1986Date of Patent: June 18, 1991Assignee: ICI Americas Inc.Inventor: Sreeramulu Nagubandi
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Patent number: 5006523Abstract: Novel compounds of the formula ##STR1## and tautomers thereof are disclosed. These compounds possess potassium channel blocking activity and, as such, are useful as antiarrhythmic agents.Type: GrantFiled: October 26, 1989Date of Patent: April 9, 1991Assignee: E. R. Squibb & Sons, Inc.Inventor: Karnail Atwal
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Diphenyl ether derivatives, their preparation and their use for controlling undesirable plant growth
Patent number: 4889554Abstract: Diphenyl ether derivatives of the formula ##STR1## where R.sup.1, R.sup.2, R.sup.3 and n have the meanings stated in the description, processes for their preparation, herbicides which contain these compounds as active ingredients, and a method of controlling undesirable plant growth by means of the novel compounds.Type: GrantFiled: October 28, 1988Date of Patent: December 26, 1989Assignee: BASF AktiengesellschaftInventors: Arno Lange, Bruno Wuerzer, Norbert Meyer -
Patent number: 4870056Abstract: Acylated cyanamide compounds useful for ethanol deterrence of the formula RCONHCN, wherein R is a lipophilic acyl group or is derived from an (N-substituted)-alpha-aminoacyl group.Type: GrantFiled: October 21, 1987Date of Patent: September 26, 1989Assignee: Regents of the University of MinnesotaInventors: Herbert T. Nagasawa, Chul-Hoon Kwon
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Patent number: 4857550Abstract: The present invention provides novel insecticidal dibenzoyl-tert-butylcarbazonitrile compounds and a method for the preparation thereof. It also provides methods for controlling insects with said dibenzoyl-tert-butylcarbazonitrile compounds and for protecting growing plants, crops, trees, shrubs and ornamentals, from attack by said insects.Type: GrantFiled: August 29, 1988Date of Patent: August 15, 1989Assignee: American Cyanamid CompanyInventors: Vekataraman Kameswaran, Donald P. Wright, Jr., Rod A. Herman
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Patent number: 4791229Abstract: A process for the preparation of an aryl cyanamide comprising reacting an arylamine of the formula ##STR1## in which Ar is aryl,R is hydrogen or alkyl, andn is 1, 2 or 3,(excepting 2-nitroaniline, 4-nitroaniline and arylamines having a nucleophilic character equal to or lower than 2-nitroaniline and 4-nitroaniline), with cyanogen chloride in 1-2 times the molar amount per mole of amino group of the arylamine initially in a homogeneous liquid phase using as reaction medium acetic acid (which is optionally diluted with water and/or a water-miscible, organic auxiliary solvent) in the presence of 1-1.5 molar equivalents of an auxiliary base for each amino group of the arylamine, there being more cyanogen chloride than equivalents of auxiliary base present in the reaction mixture at any point in time of the reaction, the pH of the reaction mixture being maintained below 7.Type: GrantFiled: October 24, 1986Date of Patent: December 13, 1988Assignee: Bayer AktiengesellschaftInventors: Rudolf Fauss, Hans-Jochem Riebel
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Patent number: 4721770Abstract: N-Cyanocarboxylic acid amide derivatives which contain two or three ##STR1## groupings in the molecule are useful as hardeners for epoxide resins.Type: GrantFiled: June 24, 1986Date of Patent: January 26, 1988Assignee: Ciba-Geigy CorporationInventors: Friedrich Stockinger, Friedrich Lohse, Roland Moser
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Patent number: 4684398Abstract: Disclosed are certain cyanoguanidines and cyanoisothioureas that are useful as herbicides.Type: GrantFiled: March 17, 1986Date of Patent: August 4, 1987Assignee: The Dow Chemical CompanyInventors: Joseph E. Dunbar, David M. Hedstrand
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Patent number: 4640703Abstract: 2-Phenoxypropionic acid cyanamides of the formula ##STR1## have a useful selective herbicidal activity against weeds, preferably grass weeds, in crops of useful plants.In this formulaR is hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.4 alkenyl, C.sub.3 -C.sub.4 alkynyl or C.sub.2 -C.sub.4 alkoxyalkyl, andT is a radical ##STR2## wherein A is oxygen or sulfur,X is fluorine, chlorine, bromine, iodine or trifluoromethyl,Y is hydrogen, fluorine, chlorine, bromine or trifluormethyl, andZ is nitrogen or the methine bridge.Type: GrantFiled: November 30, 1984Date of Patent: February 3, 1987Assignee: Ciba-Geigy CorporationInventors: Beat Bohner, Hermann Rempfler, Rolf Schurter
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Patent number: 4618712Abstract: N-Cyanocarboxlic acid amide derivatives which contain two or three ##STR1## groupings in the molecule are obtained by reacting 1 mol of a dicyanodiamine with 2 mols of a carboxylic acid anhydride or 1 mol of a dicyandiamine salt with 2 mols of a carboxylic acid halide or 1 mol of a dihalogeno compound with 2 mols of an N-cyanocarboxylic acid amide salt, or by reacting 1 mol of a carboxylic acid dichloride or trichloride with 2 or, respectively, 3 mols of a cyanamide or 1 mol of a carboxylic acid dicyandiamide or tricyantriamide salt with 2 or 3 mols of an alkylating agent.The N-cyanocarboxylic acid amide derivatives according to the invention are useful hardeners for epoxide resins.Type: GrantFiled: February 15, 1983Date of Patent: October 21, 1986Assignee: Ciba-Geigy CorporationInventors: Friedrich Stockinger, Friedrich Lohse, Roland Moser
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Patent number: 4595782Abstract: The present invention is for a process for the preparation of alkali metal salts of acyl cyanamides, especially those of aliphatic carboxylic acids by reacting carboxylic acid esters of lower alcohols with monoalkali metal cyanamides. The reaction results in a process which is simple and efficient and one which can be used in commercial scale batch or continuous operations.Type: GrantFiled: November 14, 1984Date of Patent: June 17, 1986Assignee: Henkel Kommanditgesellschaft auf AktienInventors: Christian Hase, Horst Baumann, Franz-Josef Carduck, Hubert Pawelczyk
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Patent number: 4552970Abstract: Compounds of the formula I ##STR1## in which X denotes hydrogen, fluorine, chlorine or bromine, Y and Z denote hydrogen, lower alkyl or lower alkoxy, M denotes sodium, potassium or one equivalent of calcium and L denotes a dipolar aprotic solvent, are obtained from compounds of the formula II ##STR2## in which X, Y and Z have the abovementioned meanings, and a metal cyanamide of the formula IIIM.sub.2 N--CNin which M has the abovementioned meaning, in a dipolar aprotic solvent, which after the reaction is substantially removed, whereupon a lower molecular weight aliphatic alcohol is added to the residue and the product precipitated is isolated. Nitrophenylureas of the formula IV ##STR3## in which X, Y and Z have the abovementioned meanings, are obtained from the compounds of the formula I by acid hydrolysis.Type: GrantFiled: February 1, 1984Date of Patent: November 12, 1985Assignee: Hoechst AktiengesellschaftInventors: Otto Arndt, Theodor Papenfuhs, Wolfgang Tronich
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Patent number: 4550203Abstract: N-substituted N-cyanocarboxylic acid amides are prepared by reacting 1 mol of an N-cyanocarboxylic acid amide salt with 1 mol of an alkyl halide or an alkylating agent, for example dimethyl sulfate or diethyl sulfate, in a polar aprotic solvent.The N-substituted N-cyanocarboxylic acid amides which can be obtained by the process according to the invention are useful curing agents for epoxide resins.Type: GrantFiled: February 15, 1983Date of Patent: October 29, 1985Assignee: Ciba Geigy CorporationInventors: Friedrich Stockinger, Friedrich Lohse, Helmut Zondler
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Patent number: 4529821Abstract: N-Cyanoacylamide compounds of the formula I ##STR1## wherein R.sub.1 is hydrogen, alkyl, cycloalkyl or aryl, R.sub.2 is hydrogen or alkyl and R.sub.3 is hydrogen or alkyl and R.sub.3 is alkylene or arylenealkylene, are prepared by reacting 1 mol of an N-cyanocarboxylic acid amide salt with 1 mol of a halogen compound in a polar, aprotic solvent.The N-cyanoacylamide compounds of the formula I can be used for hardening epoxide resins, for the preparation of isomelamine or for the preparation of linear polymers which can be crosslinked by heat.Type: GrantFiled: February 15, 1983Date of Patent: July 16, 1985Assignee: Ciba-Geigy CorporationInventors: Friedrich Stockinger, Friedrich Lohse, Roland Moser
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Patent number: 4435549Abstract: This invention relates to novel N-cyano amide compositions and adducts thereof of the formula ##STR1## wherein R is a simple organic moiety or a polymeric adduct with the valence of n and n is 2 or 3. The composition, per se, can be used as a curing agent for epoxy resins to form a thermoset material on heating.Type: GrantFiled: January 24, 1983Date of Patent: March 6, 1984Assignee: W. R. Grace & Co.Inventor: Shiow-Ching Lin
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Patent number: 4430319Abstract: The invention is accomplished by the formation at the site of use of the radioactive amine of the invention which is then injected immediately into the mammal for diagnostic purposes. The compounds of the invention are as follows: ##STR1## In the above compound, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently any straight or branched alkyl of between 1 and about 10 carbons; n may be between 1 and about 20.In the invention, the radio labeling of the invention compound is accomplished immediately prior to use of the radio labeled material. The compounds of the invention when boiled for about 15 minutes with iodine-123, a radioactive material, undergo a substitution of radioactive for non-radioactive iodine such that the compound becomes labeled and suitable for use. The compound itself, prior to radio labeling, is storage stable.Type: GrantFiled: May 21, 1982Date of Patent: February 7, 1984Assignee: State University of New YorkInventors: Monte Blau, Hank F. Kung, Kenneth M. Tramposch
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Patent number: 4426521Abstract: Novel cyanoguanidine derivatives, and acid addition salts thereof useful as medicines which have pharmacological actions such as anti-secretory effect, local anesthesia action and the like; and process for the preparation thereof.Type: GrantFiled: January 28, 1982Date of Patent: January 17, 1984Assignee: Eisai Co., Ltd.Inventors: Satoru Tanaka, Katsutoshi Shimada, Kazunori Hashimoto, Kiichi Ema, Koichiro Ueda
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Patent number: 4407816Abstract: New derivatives of 3-furyl-, 3-thienyl- and 3-phenyl-2-propenimidamides are disclosed, which are useful as anti-ulcer agents. These new compounds are synthesized by reacting an imino ether derived from a corresponding 3-substituted-2-propenenitrile with a suitable amine.Type: GrantFiled: August 4, 1981Date of Patent: October 4, 1983Assignee: Kotobuki Seiyaku Company LimitedInventors: Tsuyoshi Tomiyama, Akira Tomiyama
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Patent number: 4341788Abstract: This invention is directed to 2-(2-chloro-4-cyclopropyl-phenyl-imino)-imidazolidine, and acid addition salts thereof, the preparation of said compounds, and the use of said compounds as bradycardiacs.Type: GrantFiled: April 15, 1981Date of Patent: July 27, 1982Assignee: C. H. Boehringer SohnInventors: Helmut Stahle, Herbert Koppe, Werner Kummer, Wolfgang Hoefke, Ludwig Pichler
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Patent number: 4310545Abstract: This disclosure describes novel 4-(polyfluoroalkylamino)phenyl compounds useful as hypolipidemic and antiatherosclerotic agents.Type: GrantFiled: November 13, 1979Date of Patent: January 12, 1982Assignee: American Cyanamid CompanyInventor: Robert G. Shepherd
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Patent number: 4277487Abstract: Compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2, which may be the same or different, represent a hydrogen atom, a chlorine atom, or a methyl group, with the proviso that not both R.sub.1 and R.sub.2 are hydrogen, andR represents a radical selected from the group consisting of --(CH.sub.2).sub.2 --C(CH.sub.3).dbd.CH.sub.2, --(CH.sub.2).sub.2 --CH.dbd.CH.sub.2, --O--CH.sub.2 --CH.dbd.CH.sub.2, --O--(CH.sub.2).sub.2 --CH.dbd.CH.sub.2, --O--CH.sub.2 --C(CH.sub.3).dbd.CH.sub.2, --O--CH.sub.2 --CH.dbd.CH--CH.sub.3, ##STR2## and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as bradycardiacs.Type: GrantFiled: July 17, 1979Date of Patent: July 7, 1981Assignee: Boehringer Ingelheim GmbHInventors: Helmut Stahle, Herbert Koppe, Werner Kummer, Walter Kobinger, Christian Lillie, Ludwig Pichler
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Patent number: 4244957Abstract: 2-Imino-imidazolidine derivatives of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as hereinafter set forth, and pharmaceutically acceptable acid addition salts thereof, are described. The 2-imino-imidazolidine derivatives are useful in the treatment of hypertension.Type: GrantFiled: November 6, 1978Date of Patent: January 13, 1981Assignee: Hoffman-La Roche Inc.Inventor: Henri Ramuz