Acid Hydrolysis Only Of Nitrile Patents (Class 564/129)
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Patent number: 9995663Abstract: The present invention relates to a method for extracting acrylamide from a matrix comprising matrix components and acrylamide, comprising the steps: bringing said matrix in contact with water to obtain an aqueous extract, and, optionally, adding a base to the aqueous extract; loading a portion of the aqueous extract obtained in the previous step onto an inert support; allowing the inert support to absorb the aqueous extract; extracting acrylamide from the aqueous extract by passing a water immiscible organic solvent through the inert support; thereby obtaining an organic extract. It further relates to a method for analyzing acrylamide content in a matrix comprising matrix components and acrylamide.Type: GrantFiled: August 29, 2014Date of Patent: June 12, 2018Assignee: Biotage ABInventors: Alan Edgington, Lee Williams
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Patent number: 8759581Abstract: Method of preparing 1-chloroacetamido-1,3,3,5,5-pentamethylcyclohexane, an intermediate in the synthesis of 1-amino-1,3,3,5,5-pentamethylcyclohexane (Neramexane) or a pharmaceutically acceptable salt thereof, comprising step (iii): (iii) reacting 1-hydroxy-1,3,3,5,5-pentamethylcyclohexane with chloroacetonitrile in the presence of an acid, wherein 1-hydroxy-1,3,3,5,5-pentamethylcyclohexane is employed in step (iii) as obtained in the reaction of a methylmagnesium halide with 3,3,5,5-tetramethylcyclohexanone without having been subjected to a purification step.Type: GrantFiled: June 28, 2010Date of Patent: June 24, 2014Assignee: Merz Pharma GmbH & Co. KGaAInventors: Herbert Koller, Michael Pyerin
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Patent number: 8624062Abstract: A method for producing a phenylacetamide compound represented by formula (1): wherein Q represents a hydrogen atom or a halogen atom, R2 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, R4 represents an alkyl group having 1 to 4 carbon atoms, Ar represents an unsubstituted or substituted phenyl group, R5 represents R4 when R2 is a hydrogen atom, and R5 represents a hydrogen atom when R2 is an alkyl group having 1 to 4 carbon atoms; including reacting a phenylacetamide compound represented by formula (2): wherein Q, R2 and Ar have the same meanings as defined above; with a dialkyl sulfate represented by formula (3): wherein R4 has the same meaning as defined above; in the presence of a base.Type: GrantFiled: February 12, 2010Date of Patent: January 7, 2014Assignee: Sumitomo Chemical Company, LimitedInventors: Hajime Ishida, Masaji Hirota, Yoko Miyanaga, Yuya Mizushima
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Publication number: 20130211140Abstract: The present invention relates to an apparatus for metering flowable media or gases, and to the use thereof.Type: ApplicationFiled: March 15, 2013Publication date: August 15, 2013Inventors: Lorenza SARTORELLI, Andreas Perl, Udo Gropp, Arndt Selbach, Stefanie Sohnemann, Matthias Groemping, Norbert Mnich, Thomas Mertz
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Publication number: 20120232155Abstract: The invention relates to a novel hydroxyphenyl compound, to the preparation of the compound and intermediates used therein, to the use of the compound as an antibacterial medicament and pharmaceutical compositions containing the compound.Type: ApplicationFiled: November 11, 2009Publication date: September 13, 2012Inventors: Vincent Gerusz, Fabien Faivre, Mayalen Oxoby, Alexis Denis, Yannick Bonvin
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Patent number: 8212065Abstract: A method for the production of optically active ?-alkylcarbonyl compounds with retention of the stereo information of the starting compound. The starting compound used here is a carbonyl compound which has, in the ?-position, a leaving group which is substituted by an alkyl group with inversion of the configuration. The substitution of the leaving group is effected with the use of an alkylmagnesium Grignard and a zinc (II) salt or a zinc organyl. The method permits the production of optically active ?-alkylcarbonyl compounds at very mild temperatures (for example 0° C.) with the use of starting compounds which are easy to prepare and economical and nontoxic catalysts, it also being possible to achieve a very high yield.Type: GrantFiled: September 18, 2008Date of Patent: July 3, 2012Assignee: Albert-Ludwigs-Universitat FreiburgInventors: Bernhard Breit, Christopher Studte
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Publication number: 20120130127Abstract: Method of preparing 1-chloroacetamido-1,3,3,5,5-pentamethylcyclohexane, an intermediate in the synthesis of 1-amino-1,3,3,5,5-pentamethylcyclohexane (Neramexane) or a pharmaceutically acceptable salt thereof, comprising step (iii): (iii) reacting 1-hydroxy-1,3,3,5,5-pentamethylcyclohexane with chloroacetonitrile in the presence of an acid, wherein 1-hydroxy-1,3,3,5,5-pentamethylcyclohexane is employed in step (iii) as obtained in the reaction of a methylmagnesium halide with 3,3,5,5-tetramethylcyclohexanone without having been subjected to a purification step.Type: ApplicationFiled: June 28, 2010Publication date: May 24, 2012Applicant: MER PHARMA GmbH & CO. KGaAInventors: Herbert Koller, Michael Pyerin
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Publication number: 20110245494Abstract: The present invention includes methods/processes and intermediates for preparing compounds having structural Formula (I): wherein X is alkyl, substituted alkyl, alkenyl, substituted alkenyl, heteroalkyl, substituted heteroalkyl, heteroalkenyl, or substituted heteroalkenyl.Type: ApplicationFiled: July 29, 2009Publication date: October 6, 2011Applicant: SENOMYX, INC.Inventors: Catherine Tachdjian, Donald S. Karanewsky, Xiao-Qing Tang, Qing Chen, Peter Leeming, Tayyab Rashid, Daniel Levin
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Publication number: 20110104765Abstract: Provided herein are compositions including diastereomers in substantially diastereomerically pure form and enantiomers in substantially enantiomerically pure form, and processes for preparing them and converting them to metyrosine.Type: ApplicationFiled: October 29, 2010Publication date: May 5, 2011Inventors: Kevin John HALLORAN, Alex COMELY, Zhengming CHEN, Shyam KRISHNAN
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Publication number: 20100298603Abstract: Provided is a process for producing an amide (A): by hydrating a nitrile (B) at high conversion in relatively short period of time even without use of high-capacity cooling apparatuses (25, 35) and a large amount of inorganic acid (D). In the process for the present invention, a nitrile (B) is hydrated in continuous mode in the presence of an inorganic acid (D) so as to give a conversion of 80% to 98%, and the unreacted nitrile contained in the resultant hydrated reaction liquid (E) is hydrated in batch-wise mode so as to give a conversion of 99.9% or more, thereby producing an amide (A). For example, the inorganic acid (D) is sulfuric acid and the use amount thereof is 0.5 to 1-fold mol with respect to the nitrile (B), and the temperature in hydration is 40 to 70-C, and hydration is performed in continuous mode using a tubular reactor (2c), loop reactor (2d) and the like. The resultant amide (A) can be hydrolyzed to produce a thiobutanoic acid (G).Type: ApplicationFiled: January 9, 2009Publication date: November 25, 2010Inventors: Takanori Ito, Masahiro Kinoshita
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Patent number: 7705053Abstract: To provide compounds which have high angiogenesis inhibiting activity, and are useful as agents for effective treatment and prevention of diseases involving pathologic angiogenesis, for example, cancer and cancer metastasis, methods for producing the compounds, intermediate compounds useful for their production, and pharmaceutical compositions containing these compounds.Type: GrantFiled: December 27, 2004Date of Patent: April 27, 2010Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Hiroshi Koyano, Atsushi Suda, Kousuke Aso, Kihito Hada, Miyuki Asai, Masami Hasegawa, Yasuko Sato
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Patent number: 7227036Abstract: There is provided a process for producing an aminomethyl group-containing benzamide compound represented by the general formula (II): wherein —CONH2 and —X represent a substituent on the benzene ring and —CONH2 exists at the meta- or para-position of —CH2NH2, and X and n are as defined below, which comprises hydrating an aminomethyl group-containing benzonitrile compound represented by the general formula (I): wherein —CN and —X represent a substituent on the benzene ring and —CN exists at the meta- or para-position of —CH2NH2, X represents a chlorine atom or a fluorine atom, and n represents an integer of 0 to 4, provided that, when n is 2 or more, X may be the same or differentType: GrantFiled: May 2, 2003Date of Patent: June 5, 2007Assignee: Showa Denko K.K.Inventors: Yutaka Ohnishi, Hideo Miyata, Kimitaka Ohshiro
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Patent number: 6660880Abstract: A process, for the preparation of an ester of 2-hydroxy-4-methylthiobutyric acid which is substantially in the monomeric form, which process, being capable of industrial application and which comprises reacting 2-hydroxy-4-methylthiobutyric acid with an alcohol in the presence of water and an acid catalyst at a temperature of from 30 to 150° C. wherein the acid is the direct product of the hydrolysis of 2-hydroxy-4-methylthiobutyronitrile.Type: GrantFiled: February 7, 2001Date of Patent: December 9, 2003Assignee: Adisseo Ireland LimitedInventors: Michel Garrait, Claude Casse, George Gros
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Patent number: 6521794Abstract: For the production of an aromatic compound by hydrolyzing and decarboxylating a corresponding aromatic cyano compound in the presence of an acidic substance, this invention provides a method for the production of the aromaic compound, characterized by carrying out the reactions of hydrolysis and decarboxylaion in multiple steps. Particularly when the aromatic cyano compound contains a halogen, this method effectively prevents the reaction vessels from being corroded by the by-produced hydrogen halogenide and enables the target compound to be produced in a high yield.Type: GrantFiled: February 1, 2002Date of Patent: February 18, 2003Assignee: Nippon Shokubai Co., Ltd.Inventor: Kouichi Hirota
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Patent number: 6492553Abstract: A method for preparing a N-[(aliphatic or aromatic)carbonyl)]-2-aminoacetamide compound, and for preparing a cyclized compound therefrom, as well as novel resin bound intermediate compounds that are useful for preparing such compounds.Type: GrantFiled: August 4, 1999Date of Patent: December 10, 2002Assignee: Aventis Pharamaceuticals Inc.Inventors: Christopher Hulme, George C. Morton, Joseph M. Salvino, Richard F. Labaudiniere, Helen J. Mason, Matthew M. Morrissette, Liang Ma, Marie-Pierre Cherrier
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Patent number: 6482983Abstract: A process for obtaining an amide of the general formula R—(CO)—NH—CH2—X involves contacting a nitrile of the general formula R—CN with: a) an acid; and c) an alkoxy-containing compound comprising at least one alkoxy functionality of the general formula —OCH2—X; wherein R is hydrogen or an alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl, or heterocyclic substituent, which substituents can be substituted or unsubstituted; wherein X is hydrogen or a radical having the general formula —CHR1R2; and wherein R1 and R2 independently or collectively represent hydrogen or an alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl, or heterocyclic substituent, or any combination thereof, which substituents can be substituted or unsubstituted.Type: GrantFiled: July 31, 2001Date of Patent: November 19, 2002Assignee: Millennium Specialty ChemicalsInventors: Mikhail Yu. Lebedev, Mark B. Erman
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Patent number: 6479695Abstract: A process for the preparation of 2-hydroxy-4-methylthiobutyric acid ester which comprises (a) a first step of reacting 2-hydroxy-4-methylthiobutyronitrile with sulphuric acid to produce 2-hydroxy-4-methylthiobutyramide, and (b) a second step of reacting the 2-hydroxy-4-methylthiobutyramide with an alcohol to produce a 2-hydroxy-4-methylthiobutyric acid ester, the two steps being carried out in the same reaction medium.Type: GrantFiled: December 28, 2001Date of Patent: November 12, 2002Assignee: Aventis Animal Nutrition, S.A.Inventors: Michel Garrait, Claude Casse, Georges Gros
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Patent number: 6437183Abstract: The invention relates to the manufacture of amide compounds provided through the reaction of nitrile compounds and a sulfate compound to form the related amide compound. In a preferred embodiment a diol or a triol is employed as a solvent, thereby increasing the yield of the product.Type: GrantFiled: August 8, 2001Date of Patent: August 20, 2002Assignee: International Flavors & Fragrances Inc.Inventors: Richard M. Boden, Carlos Ramirez
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Patent number: 6303817Abstract: The invention relates to the manufacture of amide compounds provided through the reaction of nitrile compounds and a sulfate compound to form the related amide compound. In a preferred embodiment a diol or a triol is employed as a solvent, thereby increasing the yield of the product.Type: GrantFiled: August 10, 2000Date of Patent: October 16, 2001Assignee: International Flavors & Fragrances Inc.Inventors: Richard M. Boden, Carlos Ramirez
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Patent number: 6184414Abstract: Process for producing ammonium-2-hydroxy-4-(methylthio)-butyrate, mixtures containing the same in liquid form and their use. In order to produce ammonium-2-hydroxy-4-methylthio-n-butyrate and mixtures containing the same with a remarkable fluidity and a very low oligomer proportion by a process based on exclusively “liquid” steps, the reaction mixture is treated with a water-immiscible or partially water-miscible inert solvent, until a first organic extract and a first aqueous raffinate are obtained, and the first organic extract is decomposed into a second organic extract and a second aqueous raffinate by treating it with ammonia and phase separation. Re-extraction of MHA as MHAAS is carried out in the second aqueous raffinate, causing salt formation, and MHAAS is isolated from the second aqueous raffinate. This compound is useful as feedstuff supplement and as methionine substitute.Type: GrantFiled: January 10, 1997Date of Patent: February 6, 2001Assignee: Degussa AktiengesellschaftInventors: Helmut Suchsland, Heinz Kohl
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Patent number: 5811580Abstract: Hydrocarbyl-substituted amides can be prepared in a catalyzed Ritter reaction by contacting a nitrile with a hydrocarbylating agent, in the presence of an acidified clay as the catalyst, under conditions conducive to the formation of the hydrocarbyl-substituted amide.Type: GrantFiled: December 4, 1996Date of Patent: September 22, 1998Assignee: The Lubrizol CorporationInventor: Douglas C. Rhubright
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Patent number: 5763661Abstract: A method of preparing acylated .alpha.-amino carboxylic acid amides directly from amino nitriles in high yield and purity. The method involves acylating the amino nitrile with an acyl halide under Schotten-Baumann conditions, and hydrolyzing the resulting nitrile to the amide. The resulting acylated amino carboxylic acid amide precipitates and can be isolated by filtration in high purity.Type: GrantFiled: January 17, 1997Date of Patent: June 9, 1998Assignee: Hampshire Chemical Corp.Inventor: John B. Stallman
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Patent number: 5633288Abstract: This invention relates to a tri(lower alkoxy)benzene derivative of the general formula (I), or its salt, optical isomer or solvate, ##STR1## wherein: R.sup.1, R.sup.2 and R.sup.3 : same or different and each represents a lower alkyl group;A: a group of the formula ##STR2## and R.sup.4 and R.sup.5 : same or different and each represents a lower alkyl group, an aralkyl group or an aryl group, provided that R.sup.4 and R.sup.5 may, taken together with the adjacent nitrogen atom, form a pyrrolidinyl group, a piperidino group, a morpholino group, a thiomorpholino group, or a piperazinyl group optionally substituted by a lower alkyl group in 4-position;to pharmaceutical compositions containing the same, and to processes for their production. The compound of the invention is useful as value as a pulmonary-surfactant secretion promoting agent.Type: GrantFiled: November 22, 1995Date of Patent: May 27, 1997Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Hiromu Hara, Tatsuya Maruyama, Munetoshi Saito, Toshiyasu Mase
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Patent number: 5436371Abstract: A process for preparing p-nitroaromatic amides is provided which comprises contacting a nitrile, nitrobenzene, a suitable base and water in the presence of a suitable solvent system to form a mixture, and reacting the mixture at a suitable temperature in a confined reaction zone in the presence of a controlled amount of protic material. The p-nitroaromatic amides of the invention can be reduced to p-aminoaromatic amides. In one embodiment, the p-aminoaromatic amide is further reacted with ammonia under conditions which produce the corresponding p-aminoaromatic amine and the amide corresponding to the nitrile starting material or with water in the presence of a suitable basic or acidic catalyst under conditions which produce the corresponding p-aminoaromatic amine and the acid or salt thereof corresponding to the nitrile starting material. In another embodiment, the p-aminoaromatic amine is reductively alkylated to produce alkylated p-aminoaromatic amine.Type: GrantFiled: August 29, 1994Date of Patent: July 25, 1995Assignee: Monsanto CompanyInventors: Michael K. Stern, Brian K. Cheng
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Patent number: 5414122Abstract: There is disclosed an efficient process for producing .alpha.-ketoacetamide of the formula: ##STR1## which is useful as an intermediate for the production of various alkoxyiminoacetamide compounds to be used for agricultural fungicides. In this process, a corresponding acid halide is condensed with isocyanide to produce the .alpha.-ketoacetamide.Type: GrantFiled: August 17, 1993Date of Patent: May 9, 1995Assignee: Shionogi & Co., Ltd.Inventors: Akira Murabayashi, Hideyuki Takenaka, Hiroyuki Kai
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Patent number: 5258551Abstract: There is disclosed an efficient process for producing .alpha.-ketoacetamide of the formula: ##STR1## which is useful as an intermediate for the production of various alkoxyiminoacetamide compounds to be used for agricultural fungicides. In this process, a corresponding acid halide is condensed with isocyanide to produced the .alpha.-ketoacetamide.Type: GrantFiled: December 3, 1992Date of Patent: November 2, 1993Assignee: Shionogi & Co., Ltd.Inventors: Akira Murabayashi, Hideyuki Takenaka, Hiroyuki Kai
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Patent number: 5087751Abstract: The present invention presents a method for preparation of S-3,4-dihydroxy butyronitrile expressed by the structural formula (II) ##STR1## characterized by causing R-3-chloro-1,2-propanediol expressed by the structural formula (I) ##STR2## to react with a cyanating agent. According to this invention, optically active 3,4-dihydroxy butyronitrile and 3,4-dihydroxy butyric acid derivatives may be manufactured economically and efficiently.Type: GrantFiled: November 9, 1990Date of Patent: February 11, 1992Assignee: Kanegafuchi Kagaku Kogyo K.K.Inventors: Kenji Inoue, Mitsunori Matsumoto, Satomi Takahashi
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Patent number: 5051525Abstract: N-acyl-2-amino acid amides containing phosphinic esters, process for their preparation, and N-acyl-2-amino acid nitriles as precursorsPhosphorus-containing N-acyl-2-amino acid amides of the general formula (I) ##STR1## where R.sup.1 is alkyl, optionally substituted by halogen or alkoxy, or is benzyl or phenyl, each of which is optionally substituted by alkyl, alkoxy, halogen, nitro or CF.sub.3, or is cycloalkyl, andR.sup.2 is H, or alkyl, optionally substituted by halogen or alkoxy, or is (CH.sub.2).sub.n -phenyl, optionally substituted in the phenyl ring by alkyl, alkoxy, halogen, nitro or CF.sub.3, where n=0, 1, 2 or 3,are valuable intermediates for the preparation of L-phosphinothricin by enzymatic cleavage, and can be obtained from the corresponding N-acyl-2-amino acid nitrile by selective acid hydrolysis.Type: GrantFiled: February 2, 1990Date of Patent: September 24, 1991Assignee: Hoechst AktiengesellschaftInventor: Lothar Willms
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Patent number: 4950788Abstract: Acrylic acid or other unsaturated carboxylic acid is made by hydrolysing the corresponding nitrile in the presence of excess sulphuric acid to form amide sulphate, adding amide in an amount such that the total amount of amide and nitrile fed to the process is greater than 1 mole per mole sulphuric acid, hydrolysing the amide sulphate and amide to the desired acid and separating the acid from the sulphate by-products.Type: GrantFiled: February 23, 1989Date of Patent: August 21, 1990Assignee: Allied Colloids LimitedInventors: David Farrar, Peter Flesher
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Patent number: 4851576Abstract: This invention relates to a process for the catalytic hydrolysis of an .alpha.-aminonitrile in the heterogeneous phase, and to polymeric resins having a catalytic activity for carrying out the present process.The process according to this invention is characterized in that said .alpha.-aminonitrile or one of the salts thereof is reacted in an aqueous medium, in the heterogeneous phase and in the presence of hydroxide ions on a polymeric resin which contains side chains carrying a carbonyl group, and which is insoluble in the aqueous basic medium.Type: GrantFiled: December 28, 1982Date of Patent: July 25, 1989Assignee: Centre National de la Recherche Scientifique (CNRS)Inventors: Auguste A. Commeyras, Jacques R. Taillades, Jean Brugidou, Regine Sola, Aldo Previero, Louis Mion, Robert J. Pascal, Monique Lasperas, Alain Rousset
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Patent number: 4731447Abstract: A process for the preparation of piperidylidene-dihydro-dibenzo[a,d]cycloheptene or aza-derivatives thereof and intermediates in such process are disclosed.Type: GrantFiled: March 12, 1986Date of Patent: March 15, 1988Assignee: Schering CorporationInventors: Doris P. Schumacher, Bruce L. Murphy, Jon E. Clark
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Patent number: 4719303Abstract: A method for the preparation of substituted and unsubstituted 2-[(1-carbamoyl-1,2-dimethyl-propyl) carbamoyl]-3-quinolinecarboxylic, nicotinic and benzoic acids.Type: GrantFiled: November 21, 1983Date of Patent: January 12, 1988Assignee: American Cyanamid CompanyInventors: William H. Gastrock, Timothy F. Mason, Gregory P. Withers
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Patent number: 4611067Abstract: This invention relates to a novel process for the preparation of 3-hydroxy-3-methylglutarylcoenzyme A (HMG-CoA) reductase inhibitors which contain a 4-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one moiety, such as compactin and mevinolin, by utilizing an alkyl 4-cyano-3(R)-hydroxybutanoate as a chiral synthon for the stereospecific introduction of the 4-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one moiety.Type: GrantFiled: January 31, 1985Date of Patent: September 9, 1986Assignee: Merck & Co., Inc.Inventors: Ralph P. Volante, Thomas R. Verhoeven, Meyer Sletzinger, James M. McNamara, Thomas M. H. Liu, Edward G. Corley
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Patent number: 4596885Abstract: A process for the preparation of a phenylglyocylic acid ester of the formula ##STR1## wherein R.sup.1 represents alkyl,X represents halogen, alkyl, halogenoalkyl, alkoxy or nitro, andn represents 0, 1, 2, or 3by contacting a benzoyl cyanide of the formula ##STR2## wherein X and n have the meanings stated above, in a sulphuric acid/water system in the presence of chloride ions at a temperature between 0.degree. and 70.degree. C. to form phenylglyoxylic acid amide and reacting the phenylglyoxylic acid amide without isolation with an alcohol of the formula R.sup.1 -OH, wherein R.sup.1 has the meaning stated above, optionally in the presence of a diluent, at a temperature between 40.degree. and 100.degree. C.Type: GrantFiled: February 6, 1978Date of Patent: June 24, 1986Assignee: Bayer AktiengesellschaftInventors: Winfried Lunkenheimer, Andreas Wittig, Wilfried Draber, Helmut Timmler
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Patent number: 4552982Abstract: 9-Carbamoyl-9-(2-cyanoethyl)fluorenes are converted to 9-carbamoyl-9-(3-aminopropyl)fluorenes by catalytic hydrogenation in the presence of a strong acid.Type: GrantFiled: August 1, 1983Date of Patent: November 12, 1985Assignee: Eli Lilly and CompanyInventors: William B. Lacefield, William Pfeifer
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Patent number: 4524077Abstract: A process for the preparation of 2-hydroxy-4-methylthiobutyric acid having improved color, odor and lower viscosity. 2-hydroxy-4-methylthiobutyric acid which is also known as 2-hydroxy-4-(methylthio) butanoic acid, is hydrolyzed with sulfuric acid having an initial strength of between about 50% by weight and about 70% by weight on an organic-free basis, thereby producing an intermediate aqueous hydrolysis product solution containing 2-hydroxy-4-methylthiobutyramide. The 2-hydroxy-4-methylthiobutyramide is hydrolyzed with sulfuric acid having a strength of between about 30% by weight and about 50% by weight on an organic-free basis to produce an aqueous hydrolyzate containing 2-hydroxy-4-methylthiobutyric acid. The hydrolyzate solution is contacted with a substantially water-immiscible organic solvent in a liquid-liquid extraction system to produce an extract comprising the solvent and 2-hydroxy-4-methylthiobutyric acid transferred from the hydrolyzate. The acid product is then recovered from the extract.Type: GrantFiled: November 14, 1983Date of Patent: June 18, 1985Assignee: Monsanto CompanyInventors: Dennis A. Ruest, Masaharu Takano, Lawrence R. Wolf
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Patent number: 4250111Abstract: An improved process for catalytically hydrolyzing a nitrile to a corresponding amide which employs a reduced copper and another reduced metal catalyst. This catalyst is prepared by precipitating from an aqueous solution comprised of a mixture of a copper salt and a heavy metal salt a mixture of copper hydroxide and heavy metal hydroxide, oxidizing, heating, washing, separating and reducing under controlled conditions.Type: GrantFiled: July 12, 1976Date of Patent: February 10, 1981Assignee: Nalco Chemical CompanyInventors: Virgil L. Seale, Louis A. Goretta