Phosphorus Attached Directly To Amino Nitrogen By Nonionic Bonding Patents (Class 564/12)
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Publication number: 20110160460Abstract: The invention concerns novel ionic compounds with low melting point whereof the onium type cation having at least a heteroatom such as N, 0, S or P bearing the positive charge and whereof the anion includes, wholly or partially, at least an ion imidide such as (FXI0)N—(OX2F) wherein X1 and X2 are identical or different and comprise SO or PF, and their use as solvent in electrochemical devices. Said composition comprises a salt wherein the anionic charge is delocalised, and can be used, inter alia, as electrolyte.Type: ApplicationFiled: March 7, 2011Publication date: June 30, 2011Applicants: ACEP INC., CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE MONTREALInventors: Christophe Michot, Michel Armand, Michel Gauthier, Nathalie Ravet
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Patent number: 7964743Abstract: Compounds represented by the following general formula (1a) or (1b). A complex comprising a center metal of rhodium and a compound represented by the following general formula (1a) or (1b) as a ligand. A catalyst for optically active beta-substituted carbonyl compound synthesis and catalyst for asymmetric 1, 2 addition reaction being composed of the complex. A method of production of an optically active beta-aryl compound from an alpha, beta-unsaturated compound and an aryl-boronic acid derivative and method of production of an optically active aryl alcohol compound from an aldehyde compound and aryl boronic acid derivatives using the catalyst. A complex comprising a center metal of palladium and a compound represented by the following general formula (1a) or (1b) as a ligand. A catalyst for asymmetric allylic substitution reaction being composed of the complex.Type: GrantFiled: February 17, 2006Date of Patent: June 21, 2011Assignee: Japan Science and Technology AgencyInventors: Norio Miyaura, Yasunori Yamamoto
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Patent number: 7923582Abstract: The present invention features a chemoselective ligation reaction that can be carried out under physiological conditions. In general, the invention involves condensation of a specifically engineered phosphine, which can provide for formation of an amide bond between the two reactive partners resulting in a final product comprising a phosphine moiety, or which can be engineered to comprise a cleavable linker so that a substituent of the phosphine is transferred to the azide, releasing an oxidized phosphine byproduct and producing a native amide bond in the final product. The selectivity of the reaction and its compatibility with aqueous environments provides for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).Type: GrantFiled: January 19, 2005Date of Patent: April 12, 2011Assignee: The Regents of the University of CaliforniaInventors: Eliana Saxon, Carolyn R. Bertozzi
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Publication number: 20110077389Abstract: Novel CE-phosphoramidites and CPG reagents have been synthesized from a serinol backbone. These reagents are useful to introduce functional groups or directly label oligonucleotides. The versatile serinol scaffold allows for labeling at any position (5? or 3? termini, or any internal position) during automated DNA synthesis. Multiple labels or functional groups can be achieved by repetitive coupling cycles. Optimal spacer arms and protected label moieties have been specially designed. Further, the natural 3-carbon atom internucleotide phosphate distance is retained when inserted internally.Type: ApplicationFiled: September 28, 2010Publication date: March 31, 2011Applicants: Nelson Biotechnologies, Inc., Glen Research CorporationInventors: Paul S. Nelson, Hugh Mackie, Andrew Murphy
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Patent number: 7906681Abstract: A new P—N—P ligand is useful in ethylene oligomerizations. In combination with i) a source of chromium and ii) an activator such as methylalumoxane; the ligand of this invention may be used to prepare an oligomer product that contains a mixture of hexenes and octenes. The hexenes and octenes produced with this ligand contain very low levels of internal olefins when produced under preferred reaction conditions.Type: GrantFiled: September 20, 2010Date of Patent: March 15, 2011Assignee: Nova Chemicals (International) S.A.Inventors: Xiaoliang Gao, Charles Ashton Garret Carter, Lee Douglas Henderson
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Publication number: 20110028584Abstract: Disclosed herein is a curable cyclic phosphazene compound having a low dielectric constant, a low dielectric loss index and high thermal stability, and a method of preparing the same. The curable cyclic phosphozene polymer prepared using the compound has a low dielectric constant and excellent thermal properties, compared to conventional phosphozene polymers.Type: ApplicationFiled: July 29, 2009Publication date: February 3, 2011Inventors: Jae Choon CHO, Do Yeung Yoon, Ji Young Chang, Ho Lim, Hwa Young Lee
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Patent number: 7875739Abstract: Methods and kits for decomposing organophosphorus compounds in non-aqueous media at ambient conditions are described. Insecticides, pesticides, and chemical warfare agents can be quickly decomposed to non-toxic products. The method comprises combining the organophosphorus compound with a non-aqueous solution, preferably an alcohol, comprising metal ions and at least a trace amount of alkoxide ions. In a first preferred embodiment, the metal ion is a lanthanum ion. In a second preferred embodiment, the metal ion is a transition metal.Type: GrantFiled: March 5, 2007Date of Patent: January 25, 2011Assignee: Queen's University at KingstonInventors: R. Stanley Brown, Alexei A. Neverov, Josephine S. W. Tsang
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Publication number: 20110015061Abstract: A new P—N—P ligand is useful in ethylene oligomerizations. In combination with i) a source of chromium and ii) an activator such as methylalumoxane; the ligand of this invention may be used to prepare an oligomer product that contains a mixture of hexenes and octenes. The hexenes and octenes produced with this ligand contain very low levels of internal olefins when produced under preferred reaction conditions.Type: ApplicationFiled: September 20, 2010Publication date: January 20, 2011Inventors: Xiaoliang Gao, Charles Ashton Garret Carter, Lee Douglas Henderson
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Patent number: 7855189Abstract: The invention relates to N-phenylphosphoric acid triamides of general formula (I) to a method for the production thereof and to their use as agents for regulating or inhibiting enzymatic urea hydrolysis.Type: GrantFiled: February 4, 2005Date of Patent: December 21, 2010Assignee: SKW Stickstoffwerke Piesteritz GmbHInventors: André Hucke, Hans-Joachim Niclas, Hartmut Wozniak, Hans-Jürgen Michel, Carola Schuster
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Patent number: 7851091Abstract: There are provided compositions comprising a first compound selected from the group consisting of compounds of formulas (Ib), (III), (V), and (VII), and a second compound selected from the group consisting of compounds of formulas (IIb), (IV), (VI), and (VIII): Various chemical entities can be used for R4 to R11. These compositions can be particularly useful as anti-static agents or as electron activable precursors to a redox couple.Type: GrantFiled: December 13, 2005Date of Patent: December 14, 2010Assignee: Transfert Plus, S.E.C.Inventors: Amer Hammami, Benoît Marsan
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Patent number: 7838665Abstract: The present invention features a chemoselective ligation reaction that can be carried out under physiological conditions. In general, the invention involves condensation of a specifically engineered phosphine, which can provide for formation of an amide bond between the two reactive partners resulting in a final product comprising a phosphine moiety, or which can be engineered to comprise a cleavable linker so that a substituent of the phosphine is transferred to the azide, releasing an oxidized phosphine byproduct and producing a native amide bond in the final product. The selectivity of the reaction and its compatibility with aqueous environments provides for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).Type: GrantFiled: October 18, 2007Date of Patent: November 23, 2010Assignee: The Regents of the University of CaliforniaInventors: Eliana Saxon, Carolyn Ruth Bertozzi
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Patent number: 7829749Abstract: A new P-N-P ligand is useful in ethylene oligomerizations. In combination with i) a source of chromium and ii) an activator such as methylalumoxane; the ligand of this invention may be used to prepare an oligomer product that contains a mixture of hexenes and octenes. The hexenes and octenes produced with this ligand contain very low levels of internal olefins when produced under preferred reaction conditions.Type: GrantFiled: September 1, 2009Date of Patent: November 9, 2010Assignee: Nova Chemicals (International) S.A.Inventors: Xiaoliang Gao, Charles Ashton Garret Carter, Lee Douglas Henderson
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Publication number: 20100256268Abstract: A phosphorous flame retardant primarily includes hexachlorotriphosphazene (HCP) having poly(oxyalkylene)amine substitutes. The poly(oxyalkylene)amine includes at least two end groups. The phosphorous flame retardant can further include layered silicate clay. The layered silicate clay can be intercalated and modified with the poly(oxyalkylene)amine substitutes of HCP to effectively promote thermal stability. The flame retardant, phosphazene-poly(oxyalkylene)amine adducts, can be applied to a polymer. By the cross-linking between them, the flame-retarding property of the polymer can be improved. Also provided is a method for producing the flame retardant of phosphazene-poly(oxyalkylene)amine adducts and application thereof to a polymer.Type: ApplicationFiled: March 31, 2010Publication date: October 7, 2010Applicant: NATIONAL TAIWAN UNIVERSITYInventors: Jiang-Jen Lin, Yu-Min Chen, Yi-Lin Liao
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Patent number: 7803886Abstract: The present invention relates to a ligand and its use in a catalyst for the oligomerization of olefinic monomers, the ligand having the general formula (I); P(R4)—P(R1)(R2)?N(R3)??(I) wherein: the R1 group and R2 group are independently selected from a hydrocarbyl, substituted hydrocarbyl, heterohydrocarbyl and substituted heterohydrocarbyl group; the R3 is selected from hydrogen, a hydrocarbyl group, a substituted hydrocarbyl group, a heterohydrocarbyl group, a substituted heterohydrocarbyl group, a silyl group or derivative thereof; the R4 group is an optionally substituted alkylenedioxy, alkylenedimercapto or alkylenediamino structure which is bound to the phosphorus atom through the two oxygen, sulphur or nitrogen atoms of the alkylenedioxy, alkylenedimercapto or alkylenediamino structure or an optionally substituted arylenedioxy, arylenedimercapto or arylenediamino structure which is bound to the phosphorus atom through the two oxygen, sulphur or nitrogen atoms of the arylenedioxy, arylenedimercaptoType: GrantFiled: December 20, 2007Date of Patent: September 28, 2010Assignee: Shell Oil CompanyInventors: Eric Johannes Maria De Boer, Harry Van der Heijden, Quoc An On, Johan Paul Smit, Arie Van Zon
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Patent number: 7790923Abstract: The invention is directed to a process for the production of certain phosphorous, namely urea, thio-urea and sulphonamide phosphorous compounds. The present invention provides a process for the production of phosphorous compounds which process allows an easy and effective separation of the reaction products from impurities by applying a solid alkaline ion-exchange resin.Type: GrantFiled: January 26, 2007Date of Patent: September 7, 2010Assignee: BASF Nederland B.V. and University of AmsterdamInventors: Albertus Jacobus Sandee, Alida Maria Van Der Burg, Joost Nicolaas Hendrik Reek
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Publication number: 20100217040Abstract: The present invention relates to a 2,2?,6,6?-tetrasubstituted aminophosphine ligand and its synthesis method. The structure of the ligand is shown as below. Its synthesis method comprises: Step (1) coupling 2,6-dinitrochlorobenzene as the starting material to obtain 2,2?,6,6?-tetranitrobiphenyl; Step (2): hydrogenating the 2,2?,6,6?-tetranitrobiphenyl with Pd/C to obtain 2,2?,6,6?-tetraminobiphenyl; Step (3): reacting the 2,2?,6,6?-tetraminobiphenyl with a phosphine halide to obtain the 2,2?,6,6?-tetrasubstituted aminophosphine ligand. The ligand of the present invention is an achiral compound, and its preparation method is simple. The ligand can be converted to a chiral bimetallic catalyst with single configuration eventually through introduction of external chirality. Moreover, the ligand can be used in various asymmetric reaction catalyzed by metals with high reactivity and stereoselectivity.Type: ApplicationFiled: August 10, 2007Publication date: August 26, 2010Applicant: SHANGHAI JIAOTONG UNIVERSITYInventors: Wanbin Zhang, Fang Xie, Fang Fang
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Publication number: 20100204514Abstract: The present application is directed to i) a method for synthesizing aminophosphine (P,N) and phosphine-aminophosphine (P,N,P) ligands, ii) the use of such ligands in the preparation of metal complexes as hydrogenation catalysts, and iii) aminophosphine (P,N) and phosphine-aminophosphine (P,N,P) ligands of various structures. In particular, the methods in i) involve reacting a protected tertiary amine of formula (I) with a metal phosphide of the formula Y—PR8R9 to afford an aminophosphine of formula (II), which can then be optionally further reacted with a phosphine of the formula (III) to afford the phosphine-aminophosphine of formula (IV).Type: ApplicationFiled: June 9, 2008Publication date: August 12, 2010Inventors: Kamaluddin Abdur-Rashid, Xuanhua Chen, Rongwei Guo, Wenli Jia
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Patent number: 7771611Abstract: Novel compositions are provided containing a compound represented by the formula YOSF5 or ZOSF5, where: (a) Y is: (i) an organic cation other than (Me2N)3S+ or (ii) an inorganic cation, provided that when Y is the inorganic cation, the composition further includes a complexing agent; and (b) Z is C1-20 alkyl, aryl, cycloalkyl, combinations thereof, or analogues thereof containing at least one heteroatom, provided that the compound represented by the formula ZOSF5 is a molecular compound. Processes of making the cationic compounds are disclosed as are processes for using the compositions containing cationic compounds in nucleophilic replacement reactions to prepare the compositions containing molecular compounds including the OSF5 group.Type: GrantFiled: July 10, 2006Date of Patent: August 10, 2010Assignee: Air Products and Chemicals, Inc.Inventors: Robert George Syvret, Gauri Sankar Lal, Kristen Elaine Minnich
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Patent number: 7767852Abstract: Process for preparing aminodihalophosphines, diaminohalophosphines, triaminophosphines, phosphorous ester diamides, aminophosphines, diaminophosphines, phosphorous ester amide halides and aminophosphine halides with elimination of an acid in the presence of an auxiliary base, wherein the auxiliary base b) and the acid form a salt which is liquid at temperatures at which the desired product is not significantly decomposed during the process of separating off the liquid salt and c) the salt of the auxiliary base forms two immiscible liquid phases with the desired product or the solution of the desired product in a suitable solvent.Type: GrantFiled: January 21, 2003Date of Patent: August 3, 2010Assignee: BASF AktiengesellschaftInventors: Martin Volland, Verena Seitz, Matthias Maase, Miguel Flores, Rainer Papp, Klemens Massonne, Veit Stegmann, Klaus Halbritter, Ralf Noe, Michael Bartsch, Wolfgang Siegel, Michael Becker, Oliver Huttenloch
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Publication number: 20100183517Abstract: Compounds of the formula, A-L-B, wherein A is glutamate or a glutamate analog; L is a phosphoramidate or a phosphoramidate analog; and B is serine or a serine analog are described which are potent inhibitors of prostate-specific membrane antigen (PMSA). Such compounds are useful in treatment of prostate cancer; and when chemically attached to a fluorescent dye, can efficiently and selectively label prostate cancer cells for fluorescent imaging.Type: ApplicationFiled: January 22, 2010Publication date: July 22, 2010Applicant: CANCER TARGETED TECHNOLOGY LLCInventor: Cliff Berkman
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Patent number: 7745614Abstract: A universal linker structure is provided, in which a functional group and activating leaving group are placed on a tether, allowing the placement of an electrophile at the end of any nucleic acid sequence. The electrophile on the tether can react with a second nucleic acid carrying a nucleophile when the two nucleic acids are hybridized near one another, resulting in release of the leaving group, and creation of a functional change. The linker can be designed to destabilize the ligation product without slowing the rate of reaction. This lowers product inhibition, and the target DNA or RNA can become a catalyst for isothermally generating multiple signals for detection. This enhanced signal is demonstrated in solution experiments and in solid supported assays. The universal linkers of the present invention are simple and inexpensive to prepare, and can be appended to any polynucleotide in automated steps on a standard DNA synthesizer.Type: GrantFiled: September 1, 2005Date of Patent: June 29, 2010Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Eric Todd Kool, Hiroshi Abe
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Publication number: 20100160599Abstract: The oligophosphazene compound capable of forming a polymer which can be used as an optical material is a cyclic or linear compound including constituent units represented by the general formula (I) below in a range from 3 to 14. In the general formula (I), k is an integer of 1 to 4 and X1 is one selected from the group consisting of an oxygen atom, a sulfur atom, an NH group and an NCH3 group. A polymer made of this oligophosphazene compound exhibits high transparency and a high refractive index and is also less likely to cause optical dispersion, and thus it can be used as an optical lens, a retardation film, a light transmission body and other optical moldings.Type: ApplicationFiled: December 18, 2008Publication date: June 24, 2010Inventor: Toshiki FUSHIMI
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Publication number: 20100121056Abstract: The present invention relates to intercalator pseudonucleotides. Intercalator pseudonucleotides according to the invention are capable of being incorporated into the backbone of a nucleic acid or nucleic acid analogue and they comprise an intercalator comprising a flat conjugated system capable of co-stacking with nucleobases of DNA. The invention also relates to oligonucleotides or oligonucleotide analogues comprising at least one intercalator pseudo nucleotide. The invention furthermore relates to methods of synthesising intercalator pseudo nucleotides and methods of synthesising oligonucleotides or oligonucleotide analogues comprising at least one intercalator pseudonucleotide.Type: ApplicationFiled: August 3, 2009Publication date: May 13, 2010Applicant: Human Genetic Signatures Pty. Ltd.Inventors: Ulf Bech Christensen, Erik Bjerregaard Pedersen
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Publication number: 20100094020Abstract: The present invention provides novel phospholipid derivatives. Furthermore, the present invention provides lipid membrane structures excellent in gene/nucleic acid introduction efficiency into a cell.Type: ApplicationFiled: August 28, 2009Publication date: April 15, 2010Applicants: Eisai R&D Management Co., Ltd., National University Corporation Nagoya Institute of Technology, SHIZUOKA PREFECTURAL UNIVERSITIES CORPORATIONInventors: Takehisa DEWA, Tomohiro Asai, Mamoru Nango, Naoto Oku
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Publication number: 20100081842Abstract: A new P—N—P ligand is useful in ethylene oligomerizations. In combination with i) a source of chromium and ii) an activator such as methylalumoxane; the ligand of this invention may be used to prepare an oligomer product that contains a mixture of hexenes and octenes. The hexenes and octenes produced with this ligand contain very low levels of internal olefins when produced under preferred reaction conditions.Type: ApplicationFiled: September 1, 2009Publication date: April 1, 2010Inventors: Xiaoliang Gao, Charles Ashton Garret Carter, Lee Douglas Henderson
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Publication number: 20100081777Abstract: A new P—N—P ligand is useful in ethylene oligomerizations. In combination with i) a source of chromium and ii) an activator such as methylalumoxane; the ligand of this invention may be used to prepare an oligomer product that contains a mixture of hexenes and octenes. The hexenes and octenes produced with this ligand contain very low levels of internal olefins when produced under preferred reaction conditions.Type: ApplicationFiled: September 1, 2009Publication date: April 1, 2010Inventors: Xiaoliang Gao, Charles Ashton Garret Carter, Lee Douglas Henderson
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Publication number: 20090306400Abstract: The present invention is broadly directed to novel compounds useful for the synthesis of biologically active compounds, including taxane derivatives, and convergent processes for the preparation of these taxane derivatives and their intermediates.Type: ApplicationFiled: March 26, 2007Publication date: December 10, 2009Inventors: John T. Henri, James D. McChesney, Sylesh K. Venkataraman, Rodger L. Lamb, Jonathan E. Foster, Christian M. Sumner, Shangping Ye
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Publication number: 20090253035Abstract: A non-aqueous electrolyte cell comprises a positive electrode, a negative electrode and a non-aqueous electrolyte containing a support salt. The non-aqueous electrolyte further comprises a phosphazene derivative. The phosphazene derivative having a specified structure functions as an electrode stabilizing agent or a non-combustion agent.Type: ApplicationFiled: June 4, 2009Publication date: October 8, 2009Applicant: Bridgestone CorporationInventors: Masashi OTSUKI, Shigeki Endo, Takao Ogino, Yasuo Horikawa
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Patent number: 7592412Abstract: A release coating composition according to the present invention comprises an alkenyl functional polysiloxane (1), a silicon hydride functional polysiloxane (11) and a catalyst (111) comprising a platinum group metal. The alkenyl functional polysiloxane (1) is an alkenylterminated polysiloxane prepared by siloxane polycondensation and/or equilibration using a phosphazene base catalyst followed by neutralisation with an acidic neutralising agent. The level of catalyst (III) in the composition can be as low as 2-40 parts per million platinum group metal by weight.Type: GrantFiled: July 2, 2004Date of Patent: September 22, 2009Assignee: Dow Corning CorporationInventors: Stephen Edward Cray, Robert Alan Ekeland, Peter Cheshire Hupfield, Sarah O'Hare, David A. Rich, Marc Thibaut
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Publication number: 20090182135Abstract: The present invention provides a compound of formula (1): wherein: X is an electron-donating group, amino modifiers formed by reacting an amino alcohol with compounds of formula (1), amino-modified biomolecules formed by reacting said amino modifiers with a biomolecule and methods for producing the same.Type: ApplicationFiled: April 30, 2008Publication date: July 16, 2009Inventors: Mikhail S. Shchepinov, Pablo Bernad
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Patent number: 7560555Abstract: A process for the preparation of a compound of formula R1—Y1—P(NR2R3)2 is provided. The process comprises reacting a compound of formula PX3 with a compound of formula HNR2R3 to form a compound of formula X—P(NR2R3)2; and reacting the compound of formula X—P(NR2R3)2 with a compound of formula R1—Y1—H in the presence of a hydrocarbon solvent to form the compound of formula R1—Y1—P(NR2R3)2. R1 represents a phosphorus protecting group; R2 and R3 each independently represent an alkyl, prefer-ably a C1-6alkyl, group, or R2 and R3 are joined, together with the N to which they are attached, to form a 5-7 membered ring; Y1 represents O or S, preferably O; and X represents a halogen, preferably Cl. The preferred solvent is toluene.Type: GrantFiled: December 16, 2003Date of Patent: July 14, 2009Assignee: Avecia Biotechnology Inc.Inventors: Jonathan Mark Hardy, Stephen Edward Dinizo
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Publication number: 20090156849Abstract: Compounds represented by the following general formula (1a) or (1b). A complex comprising a center metal of rhodium and a compound represented by the following general formula (1a) or (1b) as a ligand. A catalyst for optically active beta-substituted carbonyl compound synthesis and catalyst for asymmetric 1, 2 addition reaction being composed of the complex. A method of production of an optically active beta-aryl compound from an alpha, beta-unsaturated compound and an aryl-boronic acid derivative and method of production of an optically active aryl alcohol compound from an aldehyde compound and aryl boronic acid derivatives using the catalyst. A complex comprising a center metal of palladium and a compound represented by the following general formula (1a) or (1b) as a ligand. A catalyst for asymmetric allylic substitution reaction being composed of the complex.Type: ApplicationFiled: February 17, 2006Publication date: June 18, 2009Inventors: Norio Miyaura, Yasunori Yamamoto
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Patent number: 7541462Abstract: Methods and compounds are provided for the formation of carbon-nitrogen or carbon-carbon bonds comprising reacting an amine or an aryl boronic acid with an aryl halide in the presence of a palladium catalyst, a base, and a compound of formula II:Type: GrantFiled: January 24, 2008Date of Patent: June 2, 2009Assignee: Iowa State University Research Foundation, Inc.Inventors: John G. Verkade, Sameer Urgaonkar, JuHua Xu
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Publication number: 20090069517Abstract: The present invention relates to ligands and catalyst systems and a process for the simultaneous trimerization and tetramerization of olefinic monomers using said ligands, the ligands having the general formula (I): (R1)2P—P(R1)m(R2)n?N(R3)??(I) wherein R3 is selected from hydrogen, a hydrocarbyl group, a substituted hydrocarbyl group, a heterohydrocarbyl group, a substituted heterohydrocarbyl group, a silyl group or derivative thereof; the R1 groups are independently selected from an optionally substituted aromatic group bearing a polar substituent on at least one of the ortho-positions; and the R2 groups are independently selected from hydrocarbyl, substituted hydrocarbyl, heterohydrocarbyl and substituted heterohydrocarbyl groups with the proviso that when the group is aromatic it does not contain a polar substituent at any of the ortho-positions; with the proviso that m is 0 or 1, n is 1 or 2 and the total of m+n is 2.Type: ApplicationFiled: December 20, 2007Publication date: March 12, 2009Inventors: Eric Johannes Maria DE BOER, Harry Van Der Heijden, Quoc An On, Johan Paul Smit, Arie Van Zon
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Publication number: 20090062493Abstract: The present invention relates to a ligand and its use in a catalyst for the oligomerization of olefinic monomers, the ligand having the general formula (I); P(R4)—P(R1)(R2)?N(R3)??(I) wherein: the R1 group is selected from a hydrocarbyl, substituted hydrocarbyl, heterohydrocarbyl and substituted heterohydrocarbyl group; the R2 group is selected from hydrocarbyl, substituted hydrocarbyl, heterohydrocarbyl and substituted heterohydrocarbyl groups; the R3 is selected from hydrogen, a hydrocarbyl group, a substituted hydrocarbyl group, a heterohydrocarbyl group, a substituted heterohydrocarbyl group, a silyl group or derivative thereof; the R4 group is an optionally substituted alkylenedioxy, alkylenedimercapto or alkylenediamino structure which is bound to the phosphorus atom through the two oxygen, sulphur or nitrogen atoms of the alkylenedioxy, alkylenedimercapto or alkylenediamino structure or an optionally substituted arylenedioxy, arylenedimercapto or arylenediamino structure which is bound to the phType: ApplicationFiled: December 20, 2007Publication date: March 5, 2009Inventors: Eric Johannes Maria DE BOER, Harry VAN DER HEIJDEN, Quoc An ON, Johan Paul SMIT, Arie VAN ZON
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Publication number: 20090028925Abstract: The present invention relates to compounds of phosphonic acid-containing T3 mimetics and monoesters thereof, stereoisomers, pharmaceutically acceptable salts, co-crystals, and prodrugs thereof and pharmaceutically acceptable salts and co-crystals of the prodrugs, as well as their preparation and uses for preventing and/or treating metabolic diseases such as obesity, NASH, hypercholesterolemia and hyperlipidemia, as well as associated conditions such as atherosclerosis, coronary heart disease, impaired glucose tolerance, metabolic syndrome x and diabetes.Type: ApplicationFiled: May 26, 2006Publication date: January 29, 2009Inventors: Mark D. Erion, Hongjian Jiang, Serge H. Boyer
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Publication number: 20080318767Abstract: A phosphazene-supported catalyst in which a support is bonded to a group represented by the general formula (1): wherein n, Zn?, a, b, c, d, R, R1 and D are all defined. The phosphazene-supported catalyst is highly effective to catalyze various organic reactions, and further has no reduction of activity even after recovery and reuse of the catalyst, thus it being economically advantageous. In addition, the polymerization of cyclic monomers, substitution of substituents, carbon-carbon bond forming reactions and the like can be conducted with extremely high efficiency.Type: ApplicationFiled: June 28, 2005Publication date: December 25, 2008Applicant: Mitsui Chemicals, Inc.Inventors: Naritoshi Yoshimura, Shinji Kiyono, Kazumi Mizutani, Isao Hara, Takaomi Hayashi, Tadahito Nobori, Yoshihiro Yamamoto, Miyuki Konno, Yoshihisa Inoue, Akira Matsuura, Tuneyuki Ohkubo
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Publication number: 20080286216Abstract: A nitrogen complex of an inorganic phosphate comprising the anionic sub-structure (I); whereby a nitrogen atom (N) of a complexing agent is complexed to an oxygen atom (O) of the inorganic phosphate; wherein the nitrogen atom is selected from the group consisting of a nitrogen atom of an amine group or a nitrogen atom of a N-heteroaromatic ring; and wherein A and A? are each independently selected from the group of constituents consisting of a hydroxyl group (—OH), an oxide group (—O?), the group —OR where R is alkyl or substituted alkyl; an oxygen to which a nitrogen is complexed (—0?N) wherein the nitrogen atom is selected from the group consisting of a nitrogen atom of an amine group or a nitrogen atom of a N-heteroaromatic ring; and a phosphate of the form (i); wherein each of A? and A?? are selected independently from the same group of substituents as A and A?; wherein at least one of A, A?, A? and A?? is an oxide (—O?) with the proviso that when A? and A?? are not present then at least one of A and A? iType: ApplicationFiled: December 15, 2006Publication date: November 20, 2008Inventors: David Kannar, Robert Verdicchio
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Publication number: 20080261913Abstract: Provided herein are compounds, compositions and methods for the treatment of liver disorders, including liver cancer and metabolic diseases, such as diabetes, hyperlipidemia, atherosclerosis, and obesity. Specifically, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-cancer agents.Type: ApplicationFiled: December 27, 2007Publication date: October 23, 2008Inventors: Jean-Pierre Sommadossi, Gilles Gosselin, Claire Pierra, Christian Perigaud, Suzanne Peyrottes
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Publication number: 20080242811Abstract: A new P—N—P ligand in which each phosphorus atom is bonded to two ortho-fluorine substituted phenyl groups is useful in ethylene oligomerizations. In combination with i) a source of chromium and ii) an activator such as methalumoxane; the ligand of this invention may be used to prepare an oligomer product that contains a mixture of hexenes and octenes. The hexenes and octenes produced with this ligand contain very low levels of internal olefins when produced under preferred reaction conditions.Type: ApplicationFiled: March 20, 2008Publication date: October 2, 2008Inventors: Xiaoliang Gao, Charles Ashton Garret Carter, Liangyou Fan, Lee Douglas Henderson
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Publication number: 20080227978Abstract: A process for converting a carbonyl group within a substrate to a chiral alcohol moiety comprising reacting the carbonyl containing substrate with an organoaluminium reagent in the presence of a Group 5-12 transition metal based catalyst which is complexed with a chiral ligand; novel chiral ligands and organoluminium reagents, a chiral ligand or organoaluminium reagent for use in the process.Type: ApplicationFiled: January 26, 2006Publication date: September 18, 2008Inventor: Simon Woodward
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Patent number: 7425656Abstract: Provided are a catalyst composition including a transition metal catalyst and a nitrogen-containing bidentate phosphorus compound and a process for hydroformylation reaction of olefins to prepare aldehydes which includes stirring the catalyst composition, an olefin compound, and a gas mixture of of carbon monoxide and hydrogen, under high temperature and pressure condition. Therefore, very high catalytic activity and high selectivity in normal-aldehyde or iso-aldehyde according to the type of a substiuent are ensured.Type: GrantFiled: September 15, 2005Date of Patent: September 16, 2008Assignee: LG Chem, LtdInventors: You Moon Jeon, Donghyun Ko, Sungshik Eom, O Hak Kwon, Jaehui Choi
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Publication number: 20080221353Abstract: The present invention provides an ionic liquid including a quaternary phosphonium salt represented by general formula (1): wherein R1, R2, R3, and R4 each represent a linear alkyl group having 1 to 6 carbon atoms, a branched alkyl group having 3 to 6 carbon atoms, an alicyclic alkyl group having 3 to 6 carbon atoms, or an alkoxyalkyl group represented by —(CH2)nO—R5 (wherein n is an integer of 1 to 6; and R5 represents a methyl group or an ethyl group); at least one of R1, R2, R3, and R4 is an alkoxyalkyl group; R1, R2, R3, and R4 may be the same or different; R1 and R2 together may form a ring; and X represents an anion. The present invention also provides a reaction solvent including the ionic liquid.Type: ApplicationFiled: March 5, 2008Publication date: September 11, 2008Applicant: Nippon Chemical Industrial Co., Ltd.Inventor: Katsuhiko Tsunashima
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Publication number: 20080214801Abstract: The present invention features a chemoselective ligation reaction that can be carried out under physiological conditions. In general, the invention involves condensation of a specifically engineered phosphine, which can provide for formation of an amide bond between the two reactive partners resulting in a final product comprising a phosphine moiety, or which can be engineered to comprise a cleavable linker so that a substituent of the phosphine is transferred to the azide, releasing an oxidized phosphine byproduct and producing a native amide bond in the final product. The selectivity of the reaction and its compatibility with aqueous environments provides for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).Type: ApplicationFiled: October 18, 2007Publication date: September 4, 2008Inventors: Eliana Saxon, Carolyn Ruth Bertozzi
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Publication number: 20080194831Abstract: The present invention relates to ionic liquids of low viscosity and high electrochemical stability, in particular for use in the area of electrochemistry and as solvents for carrying out chemical reactions.Type: ApplicationFiled: May 12, 2006Publication date: August 14, 2008Inventors: Nikolai (Mykola) Ignatyev, Urs Welz-Biermann, Michael Heckmeier, German Bissky, Helge Willner
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Patent number: 7385058Abstract: Methods and compounds are provided for the formation of carbon-nitrogen or carbon-carbon bonds comprising reacting an amine or an aryl boronic acid with an aryl halide in the presence of a palladium catalyst, a base, and a compound of formula II:Type: GrantFiled: September 27, 2005Date of Patent: June 10, 2008Assignee: Iowa State University Research Foundation, Inc.Inventors: John G. Verkade, Sameer Urgaonkar, JuHua Xu
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Publication number: 20080125397Abstract: 2-({2-Oxo-2-[(pyridin-3-ylmethyl)amino]ethyl}sulfonyl)ethyl N,N,N?,N?-tetrakis(2-chloroethyl)phosphorodiamidate and its acid addition salts, especially in solid form, their preparation and intermediates in their preparation, formulations containing them, and methods of treatment using them. The compounds are useful for treating cancer, alone and in combination with other anticancer therapies.Type: ApplicationFiled: November 28, 2006Publication date: May 29, 2008Inventors: Stella K. Lui, Wenli Ma, Robert M. Yee
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Patent number: 7304093Abstract: The present invention relates to novel ketone compounds, compositions comprising ketone compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising a ketone compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.Type: GrantFiled: December 24, 2003Date of Patent: December 4, 2007Assignee: Esperion Therapeutics, Inc.Inventors: Jean-Louis Dasseux, Daniela Carmen Oniciu
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Patent number: 7232928Abstract: Cycloalkanone oxime is stabilized by a method comprising bringing the cycloalkanone oxime into contact with at least one compound selected from the group consisting of oxoacids, oxoacid salts, oxoacid esters, oxoacid amides and oxides of boron or phosphorus. In accordance with the invention, the thermal stability of cycloalkanone oxime can be improved.Type: GrantFiled: November 24, 2004Date of Patent: June 19, 2007Assignee: Sumitomo Chemical Company, LimitedInventors: Masami Fukao, Noriaki Tanaka
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Patent number: 7217842Abstract: The invention concerns novel catalysts for aromatic nucleophilic substitution. Said catalysts are compounds of the general formula (I), wherein: R1, R2, R3, R4, R5, and R6, identical or different, are selected among hydrocarbon radicals; the Pn's, advantageously the same, are selected among metalloid elements of column V of a period higher than nitrogen; Z is a metalloid element of column V, advantageously distinct from Pn; preferably a nitrogen (N, P, As, Sb).Type: GrantFiled: April 12, 2002Date of Patent: May 15, 2007Assignee: Rhodia-ChimieInventors: Vincent Schanen, Henri-Jean Cristau, Marc Taillefer