Of Carboxylic Acid Patents (Class 564/138)
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Patent number: 12173233Abstract: A coated article comprises an article, and one or more amide based coatings on an outer surface of the proppant particle, the amide based coating include the reaction product of an isocyanate component that includes at least one isocyanate and a carboxylic acid component that includes one or more poly-carboxylic acids.Type: GrantFiled: May 24, 2017Date of Patent: December 24, 2024Assignee: Dow Global Technologies LLCInventors: Arjun Raghuraman, Sachit Goyal, Phillip S. Athey, Harshad M. Shah, Juan Carlos Medina, William A. Koonce
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Patent number: 11046695Abstract: There is described herein use of a compound of formula (I) below to make cyclic peptides.Type: GrantFiled: November 14, 2016Date of Patent: June 29, 2021Assignees: Zealand Pharma A/S, Universite de MontrealInventors: Manuel Perez Vazquez, M. Monzur Morshed, Jennifer L. Hickey, Marc-André Poupart, Gaoqiang Yang, James Gillard, Adam Paul Kafal, Andrew L. Roughton
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Patent number: 10981921Abstract: There is described herein use of a compound of formula (I) below to make cyclic peptides.Type: GrantFiled: August 4, 2020Date of Patent: April 20, 2021Assignee: Zealand Pharma A/SInventors: Manuel Perez Vazquez, M. Monzur Morshed, Jennifer L. Hickey, Marc-André Poupart, Gaoqiang Yang, James Gillard, Adam Paul Kafal, Andrew L. Roughton
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Patent number: 10450262Abstract: A method for purifying 1,4-diaminobutane comprising the steps of: separating a second composition including carbonate salt of 1,4-diaminobutane from a first composition including carbonate salt of 1,4-diaminobutane by distillation; and removing carbonate from carbonate salt of 1,4-diaminobutane included in the second composition to recover 1,4-diaminobutane.Type: GrantFiled: May 4, 2016Date of Patent: October 22, 2019Assignee: CJ CHEILJEDANG CORPORATIONInventors: Won Sik Gwak, Hong Xian Li, Hyun Ju Won, Hyo Hyoung Lee, Kyung Su Na, Su Jin Park, Young Lyeol Yang, Hye Won Um, Chang Yub Oh, Kyoung Min Lee
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Patent number: 9963421Abstract: Provided are a method of refining a reaction solution including a carbonate of 1,5-diaminopentane, which is produced by fermentation, through a decarbonation step and a pH adjustment step, and 1,5-diaminopentane which is refined by the above method.Type: GrantFiled: March 19, 2015Date of Patent: May 8, 2018Assignee: CJ CHEILJEDANG CORP.Inventors: Won Sik Gwak, Hyun Ju Won, Hideki Murata, Chong Ho Lee
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Publication number: 20150105587Abstract: An amorphous amide compound of the formula wherein R is selected from the group consisting of an alkyl group, an aryl group, an alkylaryl group, an arylalkyl group, and combinations thereof. An amorphous diamide compound of the formula wherein R1 is selected from the group consisting of an alkylene group, an arylene group, an alkylarylene group, an arylalkylene group, and combinations thereof.Type: ApplicationFiled: October 14, 2013Publication date: April 16, 2015Applicant: Xerox CorporationInventors: Naveen Chopra, Adela Goredema, Kentaro Morimitsu, Barkev Keoshkerian, Jennifer L. Belelie
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Publication number: 20150080607Abstract: The present invention relates in general to the use of amides of the following general formula (I) wherein R1 is a linear or branched hydrocarbyl group containing 9 to 14 carbon atoms; R2 is selected from the group consisting of methyl, ethyl and benzyl; and R3 is selected from the group consisting of hydrogen, methyl and ethyl, as solvents for organic agriculturally active ingredients, compositions comprising organic agriculturally active ingredients and such amides, methods for treating a plant utilizing such compositions, as well as some of the amides as such and methods for their production.Type: ApplicationFiled: November 21, 2014Publication date: March 19, 2015Applicant: AKZO NOBEL CHEMICALS INTERNATIONAL B.V.Inventors: Adrianus Marinus Groenewegen, Kornelis Overkempe, Peter Westbye
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Patent number: 8981148Abstract: An esteramide compound of the following formula (I): R1OOC-A-CONR2R3??(I) is described, wherein: A is a covalent bond or a methylene group —CH2—; R1 is an optionally substituted, saturated or unsaturated aliphatic or cycloaliphatic hydrocarbon group including from 5 to 36 carbon atoms, R2 and R3, either identical or different, are groups selected from a hydrogen atom, and optionally substituted hydrocarbon groups, preferably including from 1 to 36 carbon atoms, and R2 and R3 not being simultaneously hydrogen atoms. Also described, are applications for using the esteramide compound, notably as a solvent.Type: GrantFiled: March 17, 2011Date of Patent: March 17, 2015Assignee: Rhodia OperationsInventors: Massimo Guglieri, Thierry Vidal
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Patent number: 8962885Abstract: The invention relates to new ?-hydroxyalkylamides, to a method for production of same and to the use of same.Type: GrantFiled: March 10, 2011Date of Patent: February 24, 2015Assignee: Evonik Degussa GmbHInventors: Werner Grenda, Emmanouil Spyrou, Thomas Weihrauch, Christoph Lammers, Holger Loesch, Klaus Behrendt
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Publication number: 20150044696Abstract: An integrated microfluidic device for carrying out a series of fluidic operations includes a housing including a plurality of n microfluidic conduits, wherein n is at least three, and a rotating valve having an internal channel with an entrance port and an exit port that are angularly separated. The rotating valve is positionable in a first position to connect two of the n fluidic conduits via the internal channel, and upon rotating the valve to a second position, two other of the n fluidic conduits are connected by the internal channel. The device further may include one or more fluidic chambers in fluid communication with respective fluidic conduits. Fluid contained in one fluidic chamber is transferrable by application of positive or negative gas pressure through associated fluidic conduits into another fluidic chamber via the internal channel. The device may be utilized to perform a variety of fluidic operations.Type: ApplicationFiled: August 9, 2013Publication date: February 12, 2015Applicant: SHARP KABUSHIKI KAISHAInventors: Pamela Ann DOTHIE, Daniel Christopher SPENCER
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Patent number: 8937147Abstract: Processes that make nitrogen-containing compounds include converting succinic acid (SA) or monoammonium succinate (MAS) derived from a diammonium succinate (DAS)- or MAS-containing fermentation broth to produce such compounds including diaminobutane (DAB), succinic dinitrile (SDN), succinic amino nitrile (SAN), succinamide (DAM), and related polymers.Type: GrantFiled: May 18, 2011Date of Patent: January 20, 2015Inventors: Olan S. Fruchey, Leo E. Manzer, Dilum Dunuwila, Brian T. Keen, Brooke A. Albin, Nye A. Clinton, Bernard D. Dombek
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Patent number: 8916610Abstract: An acid addition salt of a nortriptyline-GABA conjugate, a novel crystalline form of a fumaric acid addition salt of a nortriptyline-GABA conjugate, and processes of preparing the forgoing are disclosed. Uses of the above-indicated forms of a nortriptyline-GABA conjugate in the treatment of CNS disorders, and in the treatment of pain in particular, are also disclosed. Further disclosed in a large-scale process of preparing a nortriptyline-GABA conjugate.Type: GrantFiled: September 22, 2011Date of Patent: December 23, 2014Assignees: Ramot at Tel-Aviv University Ltd., Bar-Ilan UniversityInventors: Abraham Nudelman, Ada Rephaeli, Irit Gil-Ad, Abraham Weizman, Mazal Shaul, Efrat Halbfinger
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Publication number: 20140364648Abstract: Ether-amide compounds having the formula RaRbC(OR1)—CHRc—CONR2R3 are described. Also described, are processes for the preparation and use thereof, especially as solvents, for example in phytosanitary formulations.Type: ApplicationFiled: August 26, 2014Publication date: December 11, 2014Inventors: Massimo GUGLIERI, Olivier JENTZER
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Patent number: 8907130Abstract: The invention relates to novel ?-hydroxyalkylamides, to a method for their production and to the use thereof.Type: GrantFiled: March 10, 2011Date of Patent: December 9, 2014Assignee: Evonik Degussa GmbHInventors: Werner Grenda, Emmanouil Spyrou, Thomas Weihrauch, Christoph Lammers, Holger Loesch, Klaus Behrendt
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Publication number: 20140343108Abstract: The present invention belongs to the field of natural medicine and pharmaceutical chemistry, and specifically relates to novel amidated derivatives of oleanolic acid according to formula (I) or a pharmaceutically acceptable salt thereof, to a process for the preparation of these compounds, compositions containing such compounds and their use in preparing antineoplastic medicaments.Type: ApplicationFiled: November 30, 2012Publication date: November 20, 2014Inventors: Frank Rong, Rongzhen Xu, Fuwen Xie, Hongxi Lai
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Patent number: 8883945Abstract: A compound of the formula R1.[(AO)n.—R2]m (I) where: R1 is the residue of a group having at least m active hydrogen atoms; AO is an alkylene oxide residue; each n is independently from 1 to 100; m is at least 2; and each R2 is independently H, a C1 to C21 hydrocarbyl, or an acyl group —OC.R3, where R3 is a C1 to C21 hydrocarbyl group, wherein on average greater than one of the R2 groups is or comprises a C4 to C21 hydrocarbyl group comprising at least two ethylenic double bonds. The compounds are particularly suitable for use in preparing aqueous emulsions or dispersions of resins and polymers, especially alkyd resins.Type: GrantFiled: December 15, 2004Date of Patent: November 11, 2014Assignees: Croda International PLC, Croda Americas LLCInventors: William Harry McNamee, Trevor Graham Blease, Johnny Denis Grade, Hanamanthsa Shankarsa Bevinakatti
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Patent number: 8877952Abstract: Methods to pre-esterify primary polyols used in converting biobased oils, oil derivatives, and modified oils to highly functionalized esters, ester polyols, amides, and amide polyols.Type: GrantFiled: December 31, 2009Date of Patent: November 4, 2014Assignee: Battelle Memorial InstituteInventors: Herman Paul Benecke, Daniel B. Garbark, Bhima Rao Vijayendran
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Publication number: 20140315831Abstract: The present disclosure is directed to a novel class of peptide-like oligomers called peptide tertiary amides (PTAs) and a combinatorial library of PTAs along with synthetic routes for the preparation of large combinatorial libraries of these compounds. The peptide tertiary amides provide an exceptional source of high affinity and selective protein ligands that are useful as tools for biological research and as drug leads, among others.Type: ApplicationFiled: October 25, 2012Publication date: October 23, 2014Inventors: Thomas Kodadek, Yu Gao
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Patent number: 8865920Abstract: Provided herein are processes for the preparation of N-acylated amines. In particular, the processes comprise contacting an amine with an acid comprising a carboxylic acid group to form the N-acylated amine.Type: GrantFiled: March 9, 2011Date of Patent: October 21, 2014Assignee: Novus International, Inc.Inventors: Richard Vonder Embse, Michael Hayes, James C. Peterson
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Patent number: 8859816Abstract: A process for the manufacture of polyamide is described. Also described, is a process comprising a stage of initial polymerization under pressure starting from monomers and a stage of finishing in the liquid phase at atmospheric pressure. The finishing stage can employ an injection of inert gas along a direction essentially parallel to that of the flow of the liquid reaction stream.Type: GrantFiled: July 12, 2011Date of Patent: October 14, 2014Assignee: Rhodia OperationsInventor: Sébastien Lomel
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Patent number: 8853453Abstract: The present invention relates to processes for reducing impurities in lacosamide during the preparation of lacosamide. The invention provides processes for minimizing or removing impurities such as (2R)-2-(acetylamino)-3-(benzylamino)-3-oxopropyl acetate of Formula II or (2R)-2-propanoylamino-N-benzyl-3-methoxypropionamide of Formula III in lacosamide.Type: GrantFiled: January 31, 2011Date of Patent: October 7, 2014Assignee: Ranbaxy Laboratories LimitedInventors: Hari Mohan Sriram, Mukesh Kumar Madhra, Mukesh Kumar Sharma
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Publication number: 20140249105Abstract: Compounds, ceramide analogues, having a cyclic structure derived from cyclopropane, cyclobutane or cyclopentane, the ring bearing two chains consisting of an amide function. Each amide function is attached to the ring by the nitrogen atom of the function and carries a hydrocarbon chain derived from a fatty acid. The amide functions can be cis or trans relative to one another. Processes for the preparation of these novel compounds as well as pharmaceutical and/or cosmetic compositions containing them.Type: ApplicationFiled: July 25, 2011Publication date: September 4, 2014Applicant: DiverchimInventors: Jean-Louis Brayer, Natacha Frison, Benoit Folleas
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Publication number: 20140235894Abstract: The invention is directed to a technique for effectively producing an amide compound suitable for use as a solvent or a detergent on a large scale and at low cost.Type: ApplicationFiled: April 24, 2014Publication date: August 21, 2014Applicant: IDEMITSU KOSAN CO., LTD.Inventors: Hinonori TASHIRO, Yasushi SHIRAKI, Makoto KASHIMA
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Publication number: 20140187546Abstract: Cystine analogs that improve the solubility of L-cystine in urine for treatment of cystinuria and which have the structure: and pharmaceutically acceptable salts, solvates and prodrugs thereof, wherein each R and R? pair are independently selected from (i) or (ii); (i) R and R? are independently selected from hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alcohol, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclic, and substituted or unsubstituted heteroaryl, or (ii) R and R? together form a substituted or unsubstituted heterocyclic ring structure, or a substituted or unsubstituted heteroaryl ring structure; X is hydrogen, or an alkyl; and Y is O or S.Type: ApplicationFiled: January 2, 2014Publication date: July 3, 2014Applicant: Rutgers, The State University of New JerseyInventors: Longqin Hu, Amrik Sahota
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Publication number: 20140187614Abstract: The present invention provides new amino lipids and a convenient method for synthesising these compounds. These (cationic) amino lipids have good properties as transfection agents. The method is an economic versatile two step synthesis allowing the preparation of various amino lipids thus leading to the assembly of a combinatorial library of transfection agents. Moreover, the present invention provides lipid particles (liposomes) containing said amino lipids and their use for delivering bioactive agents into cells. The invention encompasses also the use of lipid particles containing the cationic amino lipids as medicament.Type: ApplicationFiled: May 15, 2012Publication date: July 3, 2014Applicant: INCELLA GMBHInventors: Gary Davidson, Pavel Levkin, Linxian Li, Yi Su, David Zahner
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Patent number: 8748659Abstract: The invention is directed to a technique for effectively producing an amide compound suitable for use as a solvent or a detergent on a large scale and at low cost.Type: GrantFiled: April 28, 2010Date of Patent: June 10, 2014Assignee: Idemitsu Kosan Co., Ltd.Inventors: Hironori Tashiro, Yasushi Shiraki, Makoto Kashima
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Publication number: 20140135503Abstract: The subject of the invention is process for the preparation of the prostaglandin amides of the general formula I, where in the formula the bonds marked with dotted lines may be single or double bonds, in the case of double bounds at positions 5,6 and 13,14 they may be in cis or in trans orientation, Q stands for a hydroxyl-group and Z stands for a hydroxyl- or oxo-group, R1 and R2 independently represent hydrogen atom or a straight or branched C1-10 alkyl- or aralkyl- group, optionally substituted with —ONO2 group, or an aralkyl- or aryl- group, which contains heteroatom, R3 represents a straight or branched, saturated or unsaturated C4-6 hydrocarbon group, or a C4-10 alkylcycloalkyl- or cycloalkyl- group, or an optionally with alkyl group or halogen atom substituted phenyl-, C7-10 alkylaryl- or hetaryl- group, Y represents (CH2), group or 0 atom or S atom, and where n=0-3.Type: ApplicationFiled: May 25, 2012Publication date: May 15, 2014Applicant: CHINOIN ZRT.Inventors: Gábor Havasi, Tibor Kiss, Irén Hortobágyi, Zsuzsanna Kardos, István Lászlófi, Zoltán Bischof, Ádám Bódis
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Patent number: 8637687Abstract: Provided are processes for making an amide of a carboxylic acid by reacting an amine of the formula (I) H—NR1R2??(I) wherein R1 and R2 are the same or different, R1 comprising a C1-C4-alkyl, and R2 comprising hydrogen or a C1-C4-alkyl, the amine having a lower boiling point than water, with a carboxylic acid with at least 3 carbon atoms per molecule, said carboxylic acid optionally comprising at least one alcoholic hydroxyl group per molecule, and selecting a molar ratio of amine to carboxylic acid in the range of from 1.5:1 to 1:1. The reaction step occurs under temperature and pressure conditions at which water and amine according to formula (I) are gaseous, and in a single reactor, the water formed together with any unreacted amine is distilled off, any unreacted amine is separated from the water and said the unreacted amine is reintroduced into the reaction mixture.Type: GrantFiled: March 19, 2013Date of Patent: January 28, 2014Assignee: BASF SEInventors: Wilhelm Barlage, Javier Raya, Joaquin Bigorra Llosas, Harald Röβler
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Publication number: 20130324694Abstract: Processes for producing nitrogen containing compounds include producing hexamethylenediamine (HMD), adiponitrile (ADN), adipamide (ADM) and derivatives thereof from adipic acid (AA) obtained from fermentation broths containing diammonium adipate (DAA) or monoammonium adipate (MAA).Type: ApplicationFiled: June 10, 2011Publication date: December 5, 2013Applicant: BIOAMBER S.A.S.Inventors: Olan S. Fruchey, Leo E. Manzer, Dilum Dunuwila, Brian T. Keen, Brooke A. Albin, Nye A. Clinton, Bernard D. Dombek
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Patent number: 8581003Abstract: The present invention relates to a process for producing an aliphatic carboxylic acid amide, including the step of reacting an aliphatic carboxylic acid or an alkyl ester thereof containing an alkyl group having 1 to 4 carbon atoms with a mono- or dialkylamine containing an alkyl group or groups having 1 to 4 carbon atoms in the presence of a solid acid catalyst containing titanium oxide as a main component and an oxide or oxides of at least one element selected from elements (except titanium) belonging to Groups 4, 5 and 14 of the long form of the periodic table, wherein the catalyst has an average particle diameter of 2 ?m or more. The process for producing an aliphatic carboxylic acid amide according to the present invention has a high reaction efficiency of the reaction of the aliphatic carboxylic acid or alkyl ester thereof with the mono- or dialkylamine, and shows an excellent filtration efficiency in separation of the catalyst.Type: GrantFiled: October 31, 2008Date of Patent: November 12, 2013Assignee: KAO CorporationInventors: Michio Terasaka, Tetsuaki Fukushima
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Patent number: 8546612Abstract: The present invention relates to novel phenyl-N-acyl derivatives of biogenic amines and amino acids of general formula (I) as cyclooxynease inhibitors, possessing analgetic and anti-inflammatory properties and devoid of side effects in particular ulcerogeneity and pro-spasmodic actions, as well as capability to potentiate effect of other analgetics, and possessing in addition antihypoxic, antidepressant and anti-Parkinsonistic action; as well as to the processes for the preparation novel and known phenyl-N-acyl derivatives of biogenic amines, to a pharmaceutical composition and to an agent comprising compounds of general formula (I) as well as to use thereof and a method of treating.Type: GrantFiled: November 12, 2012Date of Patent: October 1, 2013Assignee: Obschestvo S Ogranichennoi Otvetstvennostiyu PharmenterprisesInventors: Vladimir Evgenievich Nebolsin, Tatyana Alexandrovna Kromova, Galina Alexandrovna Zheltukhina, Violetta Leonidovna Kovaleva
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Publication number: 20130245297Abstract: Provided are processes for making an amide of a carboxylic acid by reacting an amine of the formula (I) H—NR1R2 ??(I) wherein R1 and R2 are the same or different, R1 comprising a C1-C4-alkyl, and R2 comprising hydrogen or a C1-C4-alkyl, the amine having a lower boiling point than water, with a carboxylic acid with at least 3 carbon atoms per molecule, said carboxylic acid optionally comprising at least one alcoholic hydroxyl group per molecule, and selecting a molar ratio of amine to carboxylic acid in the range of from 1.5:1 to 1:1. The reaction step occurs under temperature and pressure conditions at which water and amine according to formula (I) are gaseous, and in a single reactor, the water formed together with any unreacted amine is distilled off, any unreacted amine is separated from the water and said the unreacted amine is reintroduced into the reaction mixture.Type: ApplicationFiled: March 19, 2013Publication date: September 19, 2013Applicant: BASF SEInventors: Wilhelm Barlage, Javier Raya, Joaquin Bigorra Llosas, Harald Rößler
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Publication number: 20130216486Abstract: The present invention provides synthetic routes for preparing various isomers of cyclohexane-based coolants, such as menthyl esters and menthanecarboxamide derivatives, in particular those substituted at the amide nitrogen, for example with an aromatic ring or aryl moiety. Such structures have high cooling potency and long lasting sensory effect, which make them useful in a wide variety of consumer products. One synthetic route involves a copper catalyzed coupling of a primary menthanecarboxamide with an aryl halide, such reaction working best in the presence of potassium phosphate and water. Using this synthetic route, specific isomers can be prepared including the menthanecarboxamide isomer having the same configuration as l-menthol and new isomers such as a neoisomer having opposite stereochemistry at the carboxamide (C-1) position. The neoisomer unexpectedly has potent and long lasting cooling effect.Type: ApplicationFiled: March 20, 2013Publication date: August 22, 2013Applicant: The Procter & Gamble CompanyInventor: The Procter & Gamble Company
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Publication number: 20130184347Abstract: An acid addition salt of a nortriptyline-GABA conjugate, a novel crystalline form of a fumaric acid addition salt of a nortriptyline-GABA conjugate, and processes of preparing the forgoing are disclosed. Uses of the above-indicated forms of a nortriptyline-GABA conjugate in the treatment of CNS disorders, and in the treatment of pain in particular, are also disclosed. Further disclosed in a large-scale process of preparing a nortriptyline-GABA conjugate.Type: ApplicationFiled: September 22, 2011Publication date: July 18, 2013Applicants: Ramot at Tel-Aviv University Ltd., BioLineRX Ltd., Bar-llan UniversityInventors: Abraham Nudelman, Ada Rephaeli, Irit Gil-Ad, Abraham Weizman, Mazal Shaul
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Patent number: 8487134Abstract: The invention relates to processes for preparing acylated amphetamine, methamphetamine and dexamphetamine derivatives by reacting the parent amine with the to be-coupled acid or a salt of the to-be coupled acid which acid is optionally protected, in the presence of an alkylphosphonic acid anhydride as coupling agent and, if the acid was protected then cleaving the protecting group(s), in a one-pot reaction or in two or more separate steps.Type: GrantFiled: October 9, 2008Date of Patent: July 16, 2013Assignee: Archimica, Inc.Inventors: Andreas Meudt, Richard Wisdom, Jason Helmke, Quofang Qiu, Paul Meek
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Publication number: 20130172519Abstract: Processes that make nitrogen-containing compounds include converting succinic acid (SA) or monoammonium succinate (MAS) derived from a diammonium succinate (DAS)- or MAS-containing fermentation broth to produce such compounds including diaminobutane (DAB), succinic dinitrile (SDN), succinic amino nitrile (SAN), succinamide (DAM), and related polymers.Type: ApplicationFiled: May 18, 2011Publication date: July 4, 2013Applicant: BIOAMBER S.A.S.Inventors: Olan S. Fruchey, Leo E. Manzer, Dilum Dunuwila, Brian T. Keen, Brooke A. Albin, Nye A. Clinton, Bernard D. Dombek
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Publication number: 20130144028Abstract: Processes include providing a clarified diammonium succinate (DAS)- or monoammonium succinate (MAS)- containing fermentation broth; distilling the broth of an overhead that includes water and ammonia, and a liquid bottoms that includes SA, and at least about 20 wt % water; cooling the bottoms to a temperature sufficient to cause the bottoms to separate into a liquid portion in contact with a solid portion that is substantially pure SA; separating the solid portion from the liquid portion; and converting the solid portion to produce nitrogen containing compounds such as diamino butane (DAB), succinic dinitrile (SDN), succinic amino nitrile (SAN) or succinamide (DAM) and downstream products.Type: ApplicationFiled: May 17, 2011Publication date: June 6, 2013Inventors: Olan S. Fruchey, Leo E. Manzer, Dilum Dunuwila, Brian T. Keen, Brooke A. Albin, Nye A. Clinton, Bernard D. Dombek
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Publication number: 20130131381Abstract: A process for the manufacture of polyamide is described. Also described, is a process comprising a stage of initial polymerization under pressure starting from monomers and a stage of finishing in the liquid phase at atmospheric pressure. The finishing stage can employ an injection of inert gas along a direction essentially parallel to that of the flow of the liquid reaction stream.Type: ApplicationFiled: July 12, 2011Publication date: May 23, 2013Applicant: RHODIA OPERATIONSInventor: Sébastien Lomel
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Publication number: 20130023510Abstract: The present invention provides arachidonic acid (AA) analogs and compositions containing those analogs as active agents for use in analgesic treatments. Various methods of manufacturing the inventive compounds are provided and pharmaceutical formulations, including injectable and oral dosages, are described. Certain analogs are additionally useful as antipyretic compositions and in related fever reducing treatments.Type: ApplicationFiled: May 25, 2012Publication date: January 24, 2013Applicant: Cytometix, Inc.Inventors: Lane Brostrom, John R. Falck
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Publication number: 20130012728Abstract: Provided herein are processes for the preparation of N-acylated amines. In particular, the processes comprise contacting an amine with an acid comprising a carboxylic acid group to form the N-acylated amine.Type: ApplicationFiled: March 9, 2011Publication date: January 10, 2013Applicant: NOVUS INTERNATIONAL INC.Inventors: Richard Vonder Embse, Michael Hayes, James C. Peterson
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Publication number: 20130008830Abstract: Methods and systems for reducing fouling, including particulate-induced fouling, in a hydrocarbon refining process including the steps of providing a crude hydrocarbon for a refining process and adding an antifouling agent containing a polymer base unit and a polyamine group to the crude hydrocarbon are provided. The antifouling agent can be obtained by converting a vinyl terminated polymer, such as polypropylene or poly(ethylene-co-propylene), to a terminal acyl containing functional group, followed by reacting the terminal acyl containing functional group with a polyamine compound.Type: ApplicationFiled: July 5, 2011Publication date: January 10, 2013Applicant: EXXONMOBIL RESEARCH AND ENGINEERING COMPANYInventors: Man Kit NG, Glen B. BRONS, David T. FERRUGHELLI, Hong CHENG, Kevin MALLORY, Emmanuel Ulysse, John R. Hagadorn, Donna J. CROWTHER, Patrick BRANT
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Patent number: 8334411Abstract: A method for producing a diamine includes purifying a diamine from an aqueous solution containing a diamine salt by adding an alkaline substance to the aqueous solution and then filtering the resulting solution by allowing the solution to pass through a nanofiltration membrane to remove the salt, thereby obtaining an aqueous diamine solution.Type: GrantFiled: March 11, 2009Date of Patent: December 18, 2012Assignee: Toray Industries, Inc.Inventors: Masateru Ito, Izumi Nakagawa, Koya Kato, Takashi Mimitsuka, Kenji Sawai, Shin-ichi Minegishi, Hideki Sawai, Katsushige Yamada
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Patent number: 8309765Abstract: According to one aspect of the present invention there is provided a substantially high purity D-(?)-N,N-diethyl-2-(?-naphthoxy)propionamide and a process for the manufacture of substantially higher purity D-(?)-N,N-diethyl-2-(?-naphthoxy)propionamide having chemical purity near about or above 95%, and chiral purity near about or more than 97%. According to another aspect of the invention is to provide an agrochemical compositions containing highly pure optically active D-(?)-N,N-diethyl-2-(?-naphthoxy)propionamide.Type: GrantFiled: May 5, 2008Date of Patent: November 13, 2012Assignee: United Phosphorus LimitedInventors: Jaidev Rajnikant Shroff, Vikram Rajnikant Shroff, Narendra Purushottam Karambelkar
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Publication number: 20120283103Abstract: The present invention relates in general to the use of amides of the following general formula (I) wherein R1 is a linear or branched hydrocarbyl group containing 9 to 14 carbon atoms; R2 is selected from the group consisting of methyl, ethyl and benzyl; and R3 is selected from the group consisting of hydrogen, methyl and ethyl, as solvents for organic agriculturally active ingredients, compositions comprising organic agriculturally active ingredients and such amides, methods for treating a plant utilizing such compositions, as well as some of the amides as such and methods for their production.Type: ApplicationFiled: December 23, 2010Publication date: November 8, 2012Applicant: AKZO NOBEL CHEMICALS INTERNATIONAL B.V.Inventors: Adrianus Marinus Groenewegen, Kornelis Overkempe, Peter Westbye
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Publication number: 20120277459Abstract: The invention relates to the field of pharmaceutical chemistry, specifically to processes for preparing biologically active substances (BAS), in particular creatine amides. What is proposed is a process for preparing creatine amides which comprises treating creatine with para-toluenesulfonic acid in an organic solvent with subsequent reaction of the resultant complex with compounds comprising a primary or secondary amino group in the presence of a condensing agent and a base which are introduced subsequently. The claimed process makes it possible to increase the yield of the end product by 2-5 times in comparison with analogs and also to extend the range of the compounds prepared.Type: ApplicationFiled: September 28, 2010Publication date: November 1, 2012Inventors: Sergej Vladimirovich Burov, Olga Sergeevna Veselkina, Maria Victorovna Leko
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Patent number: 8278483Abstract: The present invention provides processes for the synthesis of novel Shikimic acid head-group containing non-toxic cationic amphiphiles capable of facilitating transport of biological macromolecules into cells.Type: GrantFiled: February 7, 2007Date of Patent: October 2, 2012Assignee: Council of Scientific & Industrial ResearchInventors: Yenugonda Venkata Mahidhar, Arabinda Chaudhuri, Rama Mukherjee
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Patent number: 8183413Abstract: Provided is a process for production of a ?-amino-?-hydroxy carboxamide derivative that is important in production of drugs or the like. In the presence of a predetermined solvent, a ?-(N-protected)amino-?-hydroxycarboxylic acid is reacted with an amine to conversion to a ?-(N-protected)amino-?-hydroxy carboxamide derivative; then the derivative is deprotected for conversion to a ?-amino-?-hydroxy carboxamide derivative; and the derivative is crystallized using a protic solvent to obtain a crystal. The high-purity ?-amino-?-hydroxy carboxamide derivative can be stably produced on an industrial scale by the process.Type: GrantFiled: January 16, 2007Date of Patent: May 22, 2012Assignee: Kaneka CorporationInventors: Narumi Kishimoto, Hiroaki Yasukouchi, Toshihiro Takeda
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Patent number: 8158826Abstract: A continuous process for the production of mono- or dicarboxylic acid alkyl amides is described, which is characterized in that: fresh mono- or dicarboxylic acid is placed into a first reactor (R1) connected with a distillation column (C1) and subjected to a reaction with ammonia or gaseous alkyl amine to form a pre-mixture consisting of mono- or dicarboxylic acid alkyl amide and unreacted mono- or dicarboxylic acid, while the water of condensation is distilled off; said pre-mixture is transferred into a second reactor (R2) also equipped with a distillation column (C2) and subjected to a further reaction with ammonia or gaseous alkyl amine to substantially convert all unreacted mono- or dicarboxylic acid into mono- or dicarboxylic acid alkyl amide; and all unreacted ammonia or gaseous alkyl amine is transferred into the first reactor (R1) to start the amidation reaction.Type: GrantFiled: March 9, 2007Date of Patent: April 17, 2012Assignee: Cognis IP Management GmbHInventors: Joaquin Bigorra, Llosas, Javier Raya, Emilio Brau, Balague, Manuel Seva, Ivan Francia, Ramon Valls
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Publication number: 20120088931Abstract: The invention is directed to a technique for effectively producing an amide compound suitable for use as a solvent or a detergent on a large scale and at low cost.Type: ApplicationFiled: April 28, 2010Publication date: April 12, 2012Applicant: IDEMITSU KOSAN CO., LTD.Inventors: Hironori Tashiro, Yasushi Shiraki, Makoto Kashima
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Publication number: 20110269982Abstract: Methods to convert fatty acids to highly functionalized esters, ester polyols, amides, and amide polyols. The products can be used to make polyurethane and polyester films and foams.Type: ApplicationFiled: December 31, 2009Publication date: November 3, 2011Applicant: Battelle Memorial InstituteInventors: Herman Paul Benecke, Daniel B. Garbark, Bhima Rao Vijayendran