Of Carboxylic Acid Patents (Class 564/138)
  • Patent number: 10450262
    Abstract: A method for purifying 1,4-diaminobutane comprising the steps of: separating a second composition including carbonate salt of 1,4-diaminobutane from a first composition including carbonate salt of 1,4-diaminobutane by distillation; and removing carbonate from carbonate salt of 1,4-diaminobutane included in the second composition to recover 1,4-diaminobutane.
    Type: Grant
    Filed: May 4, 2016
    Date of Patent: October 22, 2019
    Assignee: CJ CHEILJEDANG CORPORATION
    Inventors: Won Sik Gwak, Hong Xian Li, Hyun Ju Won, Hyo Hyoung Lee, Kyung Su Na, Su Jin Park, Young Lyeol Yang, Hye Won Um, Chang Yub Oh, Kyoung Min Lee
  • Patent number: 9963421
    Abstract: Provided are a method of refining a reaction solution including a carbonate of 1,5-diaminopentane, which is produced by fermentation, through a decarbonation step and a pH adjustment step, and 1,5-diaminopentane which is refined by the above method.
    Type: Grant
    Filed: March 19, 2015
    Date of Patent: May 8, 2018
    Assignee: CJ CHEILJEDANG CORP.
    Inventors: Won Sik Gwak, Hyun Ju Won, Hideki Murata, Chong Ho Lee
  • Publication number: 20150105587
    Abstract: An amorphous amide compound of the formula wherein R is selected from the group consisting of an alkyl group, an aryl group, an alkylaryl group, an arylalkyl group, and combinations thereof. An amorphous diamide compound of the formula wherein R1 is selected from the group consisting of an alkylene group, an arylene group, an alkylarylene group, an arylalkylene group, and combinations thereof.
    Type: Application
    Filed: October 14, 2013
    Publication date: April 16, 2015
    Applicant: Xerox Corporation
    Inventors: Naveen Chopra, Adela Goredema, Kentaro Morimitsu, Barkev Keoshkerian, Jennifer L. Belelie
  • Publication number: 20150080607
    Abstract: The present invention relates in general to the use of amides of the following general formula (I) wherein R1 is a linear or branched hydrocarbyl group containing 9 to 14 carbon atoms; R2 is selected from the group consisting of methyl, ethyl and benzyl; and R3 is selected from the group consisting of hydrogen, methyl and ethyl, as solvents for organic agriculturally active ingredients, compositions comprising organic agriculturally active ingredients and such amides, methods for treating a plant utilizing such compositions, as well as some of the amides as such and methods for their production.
    Type: Application
    Filed: November 21, 2014
    Publication date: March 19, 2015
    Applicant: AKZO NOBEL CHEMICALS INTERNATIONAL B.V.
    Inventors: Adrianus Marinus Groenewegen, Kornelis Overkempe, Peter Westbye
  • Patent number: 8981148
    Abstract: An esteramide compound of the following formula (I): R1OOC-A-CONR2R3??(I) is described, wherein: A is a covalent bond or a methylene group —CH2—; R1 is an optionally substituted, saturated or unsaturated aliphatic or cycloaliphatic hydrocarbon group including from 5 to 36 carbon atoms, R2 and R3, either identical or different, are groups selected from a hydrogen atom, and optionally substituted hydrocarbon groups, preferably including from 1 to 36 carbon atoms, and R2 and R3 not being simultaneously hydrogen atoms. Also described, are applications for using the esteramide compound, notably as a solvent.
    Type: Grant
    Filed: March 17, 2011
    Date of Patent: March 17, 2015
    Assignee: Rhodia Operations
    Inventors: Massimo Guglieri, Thierry Vidal
  • Patent number: 8962885
    Abstract: The invention relates to new ?-hydroxyalkylamides, to a method for production of same and to the use of same.
    Type: Grant
    Filed: March 10, 2011
    Date of Patent: February 24, 2015
    Assignee: Evonik Degussa GmbH
    Inventors: Werner Grenda, Emmanouil Spyrou, Thomas Weihrauch, Christoph Lammers, Holger Loesch, Klaus Behrendt
  • Publication number: 20150044696
    Abstract: An integrated microfluidic device for carrying out a series of fluidic operations includes a housing including a plurality of n microfluidic conduits, wherein n is at least three, and a rotating valve having an internal channel with an entrance port and an exit port that are angularly separated. The rotating valve is positionable in a first position to connect two of the n fluidic conduits via the internal channel, and upon rotating the valve to a second position, two other of the n fluidic conduits are connected by the internal channel. The device further may include one or more fluidic chambers in fluid communication with respective fluidic conduits. Fluid contained in one fluidic chamber is transferrable by application of positive or negative gas pressure through associated fluidic conduits into another fluidic chamber via the internal channel. The device may be utilized to perform a variety of fluidic operations.
    Type: Application
    Filed: August 9, 2013
    Publication date: February 12, 2015
    Applicant: SHARP KABUSHIKI KAISHA
    Inventors: Pamela Ann DOTHIE, Daniel Christopher SPENCER
  • Patent number: 8937147
    Abstract: Processes that make nitrogen-containing compounds include converting succinic acid (SA) or monoammonium succinate (MAS) derived from a diammonium succinate (DAS)- or MAS-containing fermentation broth to produce such compounds including diaminobutane (DAB), succinic dinitrile (SDN), succinic amino nitrile (SAN), succinamide (DAM), and related polymers.
    Type: Grant
    Filed: May 18, 2011
    Date of Patent: January 20, 2015
    Inventors: Olan S. Fruchey, Leo E. Manzer, Dilum Dunuwila, Brian T. Keen, Brooke A. Albin, Nye A. Clinton, Bernard D. Dombek
  • Patent number: 8916610
    Abstract: An acid addition salt of a nortriptyline-GABA conjugate, a novel crystalline form of a fumaric acid addition salt of a nortriptyline-GABA conjugate, and processes of preparing the forgoing are disclosed. Uses of the above-indicated forms of a nortriptyline-GABA conjugate in the treatment of CNS disorders, and in the treatment of pain in particular, are also disclosed. Further disclosed in a large-scale process of preparing a nortriptyline-GABA conjugate.
    Type: Grant
    Filed: September 22, 2011
    Date of Patent: December 23, 2014
    Assignees: Ramot at Tel-Aviv University Ltd., Bar-Ilan University
    Inventors: Abraham Nudelman, Ada Rephaeli, Irit Gil-Ad, Abraham Weizman, Mazal Shaul, Efrat Halbfinger
  • Publication number: 20140364648
    Abstract: Ether-amide compounds having the formula RaRbC(OR1)—CHRc—CONR2R3 are described. Also described, are processes for the preparation and use thereof, especially as solvents, for example in phytosanitary formulations.
    Type: Application
    Filed: August 26, 2014
    Publication date: December 11, 2014
    Inventors: Massimo GUGLIERI, Olivier JENTZER
  • Patent number: 8907130
    Abstract: The invention relates to novel ?-hydroxyalkylamides, to a method for their production and to the use thereof.
    Type: Grant
    Filed: March 10, 2011
    Date of Patent: December 9, 2014
    Assignee: Evonik Degussa GmbH
    Inventors: Werner Grenda, Emmanouil Spyrou, Thomas Weihrauch, Christoph Lammers, Holger Loesch, Klaus Behrendt
  • Publication number: 20140343108
    Abstract: The present invention belongs to the field of natural medicine and pharmaceutical chemistry, and specifically relates to novel amidated derivatives of oleanolic acid according to formula (I) or a pharmaceutically acceptable salt thereof, to a process for the preparation of these compounds, compositions containing such compounds and their use in preparing antineoplastic medicaments.
    Type: Application
    Filed: November 30, 2012
    Publication date: November 20, 2014
    Inventors: Frank Rong, Rongzhen Xu, Fuwen Xie, Hongxi Lai
  • Patent number: 8883945
    Abstract: A compound of the formula R1.[(AO)n.—R2]m (I) where: R1 is the residue of a group having at least m active hydrogen atoms; AO is an alkylene oxide residue; each n is independently from 1 to 100; m is at least 2; and each R2 is independently H, a C1 to C21 hydrocarbyl, or an acyl group —OC.R3, where R3 is a C1 to C21 hydrocarbyl group, wherein on average greater than one of the R2 groups is or comprises a C4 to C21 hydrocarbyl group comprising at least two ethylenic double bonds. The compounds are particularly suitable for use in preparing aqueous emulsions or dispersions of resins and polymers, especially alkyd resins.
    Type: Grant
    Filed: December 15, 2004
    Date of Patent: November 11, 2014
    Assignees: Croda International PLC, Croda Americas LLC
    Inventors: William Harry McNamee, Trevor Graham Blease, Johnny Denis Grade, Hanamanthsa Shankarsa Bevinakatti
  • Patent number: 8877952
    Abstract: Methods to pre-esterify primary polyols used in converting biobased oils, oil derivatives, and modified oils to highly functionalized esters, ester polyols, amides, and amide polyols.
    Type: Grant
    Filed: December 31, 2009
    Date of Patent: November 4, 2014
    Assignee: Battelle Memorial Institute
    Inventors: Herman Paul Benecke, Daniel B. Garbark, Bhima Rao Vijayendran
  • Publication number: 20140315831
    Abstract: The present disclosure is directed to a novel class of peptide-like oligomers called peptide tertiary amides (PTAs) and a combinatorial library of PTAs along with synthetic routes for the preparation of large combinatorial libraries of these compounds. The peptide tertiary amides provide an exceptional source of high affinity and selective protein ligands that are useful as tools for biological research and as drug leads, among others.
    Type: Application
    Filed: October 25, 2012
    Publication date: October 23, 2014
    Inventors: Thomas Kodadek, Yu Gao
  • Patent number: 8865920
    Abstract: Provided herein are processes for the preparation of N-acylated amines. In particular, the processes comprise contacting an amine with an acid comprising a carboxylic acid group to form the N-acylated amine.
    Type: Grant
    Filed: March 9, 2011
    Date of Patent: October 21, 2014
    Assignee: Novus International, Inc.
    Inventors: Richard Vonder Embse, Michael Hayes, James C. Peterson
  • Patent number: 8859816
    Abstract: A process for the manufacture of polyamide is described. Also described, is a process comprising a stage of initial polymerization under pressure starting from monomers and a stage of finishing in the liquid phase at atmospheric pressure. The finishing stage can employ an injection of inert gas along a direction essentially parallel to that of the flow of the liquid reaction stream.
    Type: Grant
    Filed: July 12, 2011
    Date of Patent: October 14, 2014
    Assignee: Rhodia Operations
    Inventor: Sébastien Lomel
  • Patent number: 8853453
    Abstract: The present invention relates to processes for reducing impurities in lacosamide during the preparation of lacosamide. The invention provides processes for minimizing or removing impurities such as (2R)-2-(acetylamino)-3-(benzylamino)-3-oxopropyl acetate of Formula II or (2R)-2-propanoylamino-N-benzyl-3-methoxypropionamide of Formula III in lacosamide.
    Type: Grant
    Filed: January 31, 2011
    Date of Patent: October 7, 2014
    Assignee: Ranbaxy Laboratories Limited
    Inventors: Hari Mohan Sriram, Mukesh Kumar Madhra, Mukesh Kumar Sharma
  • Publication number: 20140249105
    Abstract: Compounds, ceramide analogues, having a cyclic structure derived from cyclopropane, cyclobutane or cyclopentane, the ring bearing two chains consisting of an amide function. Each amide function is attached to the ring by the nitrogen atom of the function and carries a hydrocarbon chain derived from a fatty acid. The amide functions can be cis or trans relative to one another. Processes for the preparation of these novel compounds as well as pharmaceutical and/or cosmetic compositions containing them.
    Type: Application
    Filed: July 25, 2011
    Publication date: September 4, 2014
    Applicant: Diverchim
    Inventors: Jean-Louis Brayer, Natacha Frison, Benoit Folleas
  • Publication number: 20140235894
    Abstract: The invention is directed to a technique for effectively producing an amide compound suitable for use as a solvent or a detergent on a large scale and at low cost.
    Type: Application
    Filed: April 24, 2014
    Publication date: August 21, 2014
    Applicant: IDEMITSU KOSAN CO., LTD.
    Inventors: Hinonori TASHIRO, Yasushi SHIRAKI, Makoto KASHIMA
  • Publication number: 20140187546
    Abstract: Cystine analogs that improve the solubility of L-cystine in urine for treatment of cystinuria and which have the structure: and pharmaceutically acceptable salts, solvates and prodrugs thereof, wherein each R and R? pair are independently selected from (i) or (ii); (i) R and R? are independently selected from hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alcohol, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclic, and substituted or unsubstituted heteroaryl, or (ii) R and R? together form a substituted or unsubstituted heterocyclic ring structure, or a substituted or unsubstituted heteroaryl ring structure; X is hydrogen, or an alkyl; and Y is O or S.
    Type: Application
    Filed: January 2, 2014
    Publication date: July 3, 2014
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Longqin Hu, Amrik Sahota
  • Publication number: 20140187614
    Abstract: The present invention provides new amino lipids and a convenient method for synthesising these compounds. These (cationic) amino lipids have good properties as transfection agents. The method is an economic versatile two step synthesis allowing the preparation of various amino lipids thus leading to the assembly of a combinatorial library of transfection agents. Moreover, the present invention provides lipid particles (liposomes) containing said amino lipids and their use for delivering bioactive agents into cells. The invention encompasses also the use of lipid particles containing the cationic amino lipids as medicament.
    Type: Application
    Filed: May 15, 2012
    Publication date: July 3, 2014
    Applicant: INCELLA GMBH
    Inventors: Gary Davidson, Pavel Levkin, Linxian Li, Yi Su, David Zahner
  • Patent number: 8748659
    Abstract: The invention is directed to a technique for effectively producing an amide compound suitable for use as a solvent or a detergent on a large scale and at low cost.
    Type: Grant
    Filed: April 28, 2010
    Date of Patent: June 10, 2014
    Assignee: Idemitsu Kosan Co., Ltd.
    Inventors: Hironori Tashiro, Yasushi Shiraki, Makoto Kashima
  • Publication number: 20140135503
    Abstract: The subject of the invention is process for the preparation of the prostaglandin amides of the general formula I, where in the formula the bonds marked with dotted lines may be single or double bonds, in the case of double bounds at positions 5,6 and 13,14 they may be in cis or in trans orientation, Q stands for a hydroxyl-group and Z stands for a hydroxyl- or oxo-group, R1 and R2 independently represent hydrogen atom or a straight or branched C1-10 alkyl- or aralkyl- group, optionally substituted with —ONO2 group, or an aralkyl- or aryl- group, which contains heteroatom, R3 represents a straight or branched, saturated or unsaturated C4-6 hydrocarbon group, or a C4-10 alkylcycloalkyl- or cycloalkyl- group, or an optionally with alkyl group or halogen atom substituted phenyl-, C7-10 alkylaryl- or hetaryl- group, Y represents (CH2), group or 0 atom or S atom, and where n=0-3.
    Type: Application
    Filed: May 25, 2012
    Publication date: May 15, 2014
    Applicant: CHINOIN ZRT.
    Inventors: Gábor Havasi, Tibor Kiss, Irén Hortobágyi, Zsuzsanna Kardos, István Lászlófi, Zoltán Bischof, Ádám Bódis
  • Patent number: 8637687
    Abstract: Provided are processes for making an amide of a carboxylic acid by reacting an amine of the formula (I) H—NR1R2??(I) wherein R1 and R2 are the same or different, R1 comprising a C1-C4-alkyl, and R2 comprising hydrogen or a C1-C4-alkyl, the amine having a lower boiling point than water, with a carboxylic acid with at least 3 carbon atoms per molecule, said carboxylic acid optionally comprising at least one alcoholic hydroxyl group per molecule, and selecting a molar ratio of amine to carboxylic acid in the range of from 1.5:1 to 1:1. The reaction step occurs under temperature and pressure conditions at which water and amine according to formula (I) are gaseous, and in a single reactor, the water formed together with any unreacted amine is distilled off, any unreacted amine is separated from the water and said the unreacted amine is reintroduced into the reaction mixture.
    Type: Grant
    Filed: March 19, 2013
    Date of Patent: January 28, 2014
    Assignee: BASF SE
    Inventors: Wilhelm Barlage, Javier Raya, Joaquin Bigorra Llosas, Harald Röβler
  • Publication number: 20130324694
    Abstract: Processes for producing nitrogen containing compounds include producing hexamethylenediamine (HMD), adiponitrile (ADN), adipamide (ADM) and derivatives thereof from adipic acid (AA) obtained from fermentation broths containing diammonium adipate (DAA) or monoammonium adipate (MAA).
    Type: Application
    Filed: June 10, 2011
    Publication date: December 5, 2013
    Applicant: BIOAMBER S.A.S.
    Inventors: Olan S. Fruchey, Leo E. Manzer, Dilum Dunuwila, Brian T. Keen, Brooke A. Albin, Nye A. Clinton, Bernard D. Dombek
  • Patent number: 8581003
    Abstract: The present invention relates to a process for producing an aliphatic carboxylic acid amide, including the step of reacting an aliphatic carboxylic acid or an alkyl ester thereof containing an alkyl group having 1 to 4 carbon atoms with a mono- or dialkylamine containing an alkyl group or groups having 1 to 4 carbon atoms in the presence of a solid acid catalyst containing titanium oxide as a main component and an oxide or oxides of at least one element selected from elements (except titanium) belonging to Groups 4, 5 and 14 of the long form of the periodic table, wherein the catalyst has an average particle diameter of 2 ?m or more. The process for producing an aliphatic carboxylic acid amide according to the present invention has a high reaction efficiency of the reaction of the aliphatic carboxylic acid or alkyl ester thereof with the mono- or dialkylamine, and shows an excellent filtration efficiency in separation of the catalyst.
    Type: Grant
    Filed: October 31, 2008
    Date of Patent: November 12, 2013
    Assignee: KAO Corporation
    Inventors: Michio Terasaka, Tetsuaki Fukushima
  • Patent number: 8546612
    Abstract: The present invention relates to novel phenyl-N-acyl derivatives of biogenic amines and amino acids of general formula (I) as cyclooxynease inhibitors, possessing analgetic and anti-inflammatory properties and devoid of side effects in particular ulcerogeneity and pro-spasmodic actions, as well as capability to potentiate effect of other analgetics, and possessing in addition antihypoxic, antidepressant and anti-Parkinsonistic action; as well as to the processes for the preparation novel and known phenyl-N-acyl derivatives of biogenic amines, to a pharmaceutical composition and to an agent comprising compounds of general formula (I) as well as to use thereof and a method of treating.
    Type: Grant
    Filed: November 12, 2012
    Date of Patent: October 1, 2013
    Assignee: Obschestvo S Ogranichennoi Otvetstvennostiyu Pharmenterprises
    Inventors: Vladimir Evgenievich Nebolsin, Tatyana Alexandrovna Kromova, Galina Alexandrovna Zheltukhina, Violetta Leonidovna Kovaleva
  • Publication number: 20130245297
    Abstract: Provided are processes for making an amide of a carboxylic acid by reacting an amine of the formula (I) H—NR1R2 ??(I) wherein R1 and R2 are the same or different, R1 comprising a C1-C4-alkyl, and R2 comprising hydrogen or a C1-C4-alkyl, the amine having a lower boiling point than water, with a carboxylic acid with at least 3 carbon atoms per molecule, said carboxylic acid optionally comprising at least one alcoholic hydroxyl group per molecule, and selecting a molar ratio of amine to carboxylic acid in the range of from 1.5:1 to 1:1. The reaction step occurs under temperature and pressure conditions at which water and amine according to formula (I) are gaseous, and in a single reactor, the water formed together with any unreacted amine is distilled off, any unreacted amine is separated from the water and said the unreacted amine is reintroduced into the reaction mixture.
    Type: Application
    Filed: March 19, 2013
    Publication date: September 19, 2013
    Applicant: BASF SE
    Inventors: Wilhelm Barlage, Javier Raya, Joaquin Bigorra Llosas, Harald Rößler
  • Publication number: 20130216486
    Abstract: The present invention provides synthetic routes for preparing various isomers of cyclohexane-based coolants, such as menthyl esters and menthanecarboxamide derivatives, in particular those substituted at the amide nitrogen, for example with an aromatic ring or aryl moiety. Such structures have high cooling potency and long lasting sensory effect, which make them useful in a wide variety of consumer products. One synthetic route involves a copper catalyzed coupling of a primary menthanecarboxamide with an aryl halide, such reaction working best in the presence of potassium phosphate and water. Using this synthetic route, specific isomers can be prepared including the menthanecarboxamide isomer having the same configuration as l-menthol and new isomers such as a neoisomer having opposite stereochemistry at the carboxamide (C-1) position. The neoisomer unexpectedly has potent and long lasting cooling effect.
    Type: Application
    Filed: March 20, 2013
    Publication date: August 22, 2013
    Applicant: The Procter & Gamble Company
    Inventor: The Procter & Gamble Company
  • Publication number: 20130184347
    Abstract: An acid addition salt of a nortriptyline-GABA conjugate, a novel crystalline form of a fumaric acid addition salt of a nortriptyline-GABA conjugate, and processes of preparing the forgoing are disclosed. Uses of the above-indicated forms of a nortriptyline-GABA conjugate in the treatment of CNS disorders, and in the treatment of pain in particular, are also disclosed. Further disclosed in a large-scale process of preparing a nortriptyline-GABA conjugate.
    Type: Application
    Filed: September 22, 2011
    Publication date: July 18, 2013
    Applicants: Ramot at Tel-Aviv University Ltd., BioLineRX Ltd., Bar-llan University
    Inventors: Abraham Nudelman, Ada Rephaeli, Irit Gil-Ad, Abraham Weizman, Mazal Shaul
  • Patent number: 8487134
    Abstract: The invention relates to processes for preparing acylated amphetamine, methamphetamine and dexamphetamine derivatives by reacting the parent amine with the to be-coupled acid or a salt of the to-be coupled acid which acid is optionally protected, in the presence of an alkylphosphonic acid anhydride as coupling agent and, if the acid was protected then cleaving the protecting group(s), in a one-pot reaction or in two or more separate steps.
    Type: Grant
    Filed: October 9, 2008
    Date of Patent: July 16, 2013
    Assignee: Archimica, Inc.
    Inventors: Andreas Meudt, Richard Wisdom, Jason Helmke, Quofang Qiu, Paul Meek
  • Publication number: 20130172519
    Abstract: Processes that make nitrogen-containing compounds include converting succinic acid (SA) or monoammonium succinate (MAS) derived from a diammonium succinate (DAS)- or MAS-containing fermentation broth to produce such compounds including diaminobutane (DAB), succinic dinitrile (SDN), succinic amino nitrile (SAN), succinamide (DAM), and related polymers.
    Type: Application
    Filed: May 18, 2011
    Publication date: July 4, 2013
    Applicant: BIOAMBER S.A.S.
    Inventors: Olan S. Fruchey, Leo E. Manzer, Dilum Dunuwila, Brian T. Keen, Brooke A. Albin, Nye A. Clinton, Bernard D. Dombek
  • Publication number: 20130144028
    Abstract: Processes include providing a clarified diammonium succinate (DAS)- or monoammonium succinate (MAS)- containing fermentation broth; distilling the broth of an overhead that includes water and ammonia, and a liquid bottoms that includes SA, and at least about 20 wt % water; cooling the bottoms to a temperature sufficient to cause the bottoms to separate into a liquid portion in contact with a solid portion that is substantially pure SA; separating the solid portion from the liquid portion; and converting the solid portion to produce nitrogen containing compounds such as diamino butane (DAB), succinic dinitrile (SDN), succinic amino nitrile (SAN) or succinamide (DAM) and downstream products.
    Type: Application
    Filed: May 17, 2011
    Publication date: June 6, 2013
    Inventors: Olan S. Fruchey, Leo E. Manzer, Dilum Dunuwila, Brian T. Keen, Brooke A. Albin, Nye A. Clinton, Bernard D. Dombek
  • Publication number: 20130131381
    Abstract: A process for the manufacture of polyamide is described. Also described, is a process comprising a stage of initial polymerization under pressure starting from monomers and a stage of finishing in the liquid phase at atmospheric pressure. The finishing stage can employ an injection of inert gas along a direction essentially parallel to that of the flow of the liquid reaction stream.
    Type: Application
    Filed: July 12, 2011
    Publication date: May 23, 2013
    Applicant: RHODIA OPERATIONS
    Inventor: Sébastien Lomel
  • Publication number: 20130023510
    Abstract: The present invention provides arachidonic acid (AA) analogs and compositions containing those analogs as active agents for use in analgesic treatments. Various methods of manufacturing the inventive compounds are provided and pharmaceutical formulations, including injectable and oral dosages, are described. Certain analogs are additionally useful as antipyretic compositions and in related fever reducing treatments.
    Type: Application
    Filed: May 25, 2012
    Publication date: January 24, 2013
    Applicant: Cytometix, Inc.
    Inventors: Lane Brostrom, John R. Falck
  • Publication number: 20130012728
    Abstract: Provided herein are processes for the preparation of N-acylated amines. In particular, the processes comprise contacting an amine with an acid comprising a carboxylic acid group to form the N-acylated amine.
    Type: Application
    Filed: March 9, 2011
    Publication date: January 10, 2013
    Applicant: NOVUS INTERNATIONAL INC.
    Inventors: Richard Vonder Embse, Michael Hayes, James C. Peterson
  • Publication number: 20130008830
    Abstract: Methods and systems for reducing fouling, including particulate-induced fouling, in a hydrocarbon refining process including the steps of providing a crude hydrocarbon for a refining process and adding an antifouling agent containing a polymer base unit and a polyamine group to the crude hydrocarbon are provided. The antifouling agent can be obtained by converting a vinyl terminated polymer, such as polypropylene or poly(ethylene-co-propylene), to a terminal acyl containing functional group, followed by reacting the terminal acyl containing functional group with a polyamine compound.
    Type: Application
    Filed: July 5, 2011
    Publication date: January 10, 2013
    Applicant: EXXONMOBIL RESEARCH AND ENGINEERING COMPANY
    Inventors: Man Kit NG, Glen B. BRONS, David T. FERRUGHELLI, Hong CHENG, Kevin MALLORY, Emmanuel Ulysse, John R. Hagadorn, Donna J. CROWTHER, Patrick BRANT
  • Patent number: 8334411
    Abstract: A method for producing a diamine includes purifying a diamine from an aqueous solution containing a diamine salt by adding an alkaline substance to the aqueous solution and then filtering the resulting solution by allowing the solution to pass through a nanofiltration membrane to remove the salt, thereby obtaining an aqueous diamine solution.
    Type: Grant
    Filed: March 11, 2009
    Date of Patent: December 18, 2012
    Assignee: Toray Industries, Inc.
    Inventors: Masateru Ito, Izumi Nakagawa, Koya Kato, Takashi Mimitsuka, Kenji Sawai, Shin-ichi Minegishi, Hideki Sawai, Katsushige Yamada
  • Patent number: 8309765
    Abstract: According to one aspect of the present invention there is provided a substantially high purity D-(?)-N,N-diethyl-2-(?-naphthoxy)propionamide and a process for the manufacture of substantially higher purity D-(?)-N,N-diethyl-2-(?-naphthoxy)propionamide having chemical purity near about or above 95%, and chiral purity near about or more than 97%. According to another aspect of the invention is to provide an agrochemical compositions containing highly pure optically active D-(?)-N,N-diethyl-2-(?-naphthoxy)propionamide.
    Type: Grant
    Filed: May 5, 2008
    Date of Patent: November 13, 2012
    Assignee: United Phosphorus Limited
    Inventors: Jaidev Rajnikant Shroff, Vikram Rajnikant Shroff, Narendra Purushottam Karambelkar
  • Publication number: 20120283103
    Abstract: The present invention relates in general to the use of amides of the following general formula (I) wherein R1 is a linear or branched hydrocarbyl group containing 9 to 14 carbon atoms; R2 is selected from the group consisting of methyl, ethyl and benzyl; and R3 is selected from the group consisting of hydrogen, methyl and ethyl, as solvents for organic agriculturally active ingredients, compositions comprising organic agriculturally active ingredients and such amides, methods for treating a plant utilizing such compositions, as well as some of the amides as such and methods for their production.
    Type: Application
    Filed: December 23, 2010
    Publication date: November 8, 2012
    Applicant: AKZO NOBEL CHEMICALS INTERNATIONAL B.V.
    Inventors: Adrianus Marinus Groenewegen, Kornelis Overkempe, Peter Westbye
  • Publication number: 20120277459
    Abstract: The invention relates to the field of pharmaceutical chemistry, specifically to processes for preparing biologically active substances (BAS), in particular creatine amides. What is proposed is a process for preparing creatine amides which comprises treating creatine with para-toluenesulfonic acid in an organic solvent with subsequent reaction of the resultant complex with compounds comprising a primary or secondary amino group in the presence of a condensing agent and a base which are introduced subsequently. The claimed process makes it possible to increase the yield of the end product by 2-5 times in comparison with analogs and also to extend the range of the compounds prepared.
    Type: Application
    Filed: September 28, 2010
    Publication date: November 1, 2012
    Inventors: Sergej Vladimirovich Burov, Olga Sergeevna Veselkina, Maria Victorovna Leko
  • Patent number: 8278483
    Abstract: The present invention provides processes for the synthesis of novel Shikimic acid head-group containing non-toxic cationic amphiphiles capable of facilitating transport of biological macromolecules into cells.
    Type: Grant
    Filed: February 7, 2007
    Date of Patent: October 2, 2012
    Assignee: Council of Scientific & Industrial Research
    Inventors: Yenugonda Venkata Mahidhar, Arabinda Chaudhuri, Rama Mukherjee
  • Patent number: 8183413
    Abstract: Provided is a process for production of a ?-amino-?-hydroxy carboxamide derivative that is important in production of drugs or the like. In the presence of a predetermined solvent, a ?-(N-protected)amino-?-hydroxycarboxylic acid is reacted with an amine to conversion to a ?-(N-protected)amino-?-hydroxy carboxamide derivative; then the derivative is deprotected for conversion to a ?-amino-?-hydroxy carboxamide derivative; and the derivative is crystallized using a protic solvent to obtain a crystal. The high-purity ?-amino-?-hydroxy carboxamide derivative can be stably produced on an industrial scale by the process.
    Type: Grant
    Filed: January 16, 2007
    Date of Patent: May 22, 2012
    Assignee: Kaneka Corporation
    Inventors: Narumi Kishimoto, Hiroaki Yasukouchi, Toshihiro Takeda
  • Patent number: 8158826
    Abstract: A continuous process for the production of mono- or dicarboxylic acid alkyl amides is described, which is characterized in that: fresh mono- or dicarboxylic acid is placed into a first reactor (R1) connected with a distillation column (C1) and subjected to a reaction with ammonia or gaseous alkyl amine to form a pre-mixture consisting of mono- or dicarboxylic acid alkyl amide and unreacted mono- or dicarboxylic acid, while the water of condensation is distilled off; said pre-mixture is transferred into a second reactor (R2) also equipped with a distillation column (C2) and subjected to a further reaction with ammonia or gaseous alkyl amine to substantially convert all unreacted mono- or dicarboxylic acid into mono- or dicarboxylic acid alkyl amide; and all unreacted ammonia or gaseous alkyl amine is transferred into the first reactor (R1) to start the amidation reaction.
    Type: Grant
    Filed: March 9, 2007
    Date of Patent: April 17, 2012
    Assignee: Cognis IP Management GmbH
    Inventors: Joaquin Bigorra, Llosas, Javier Raya, Emilio Brau, Balague, Manuel Seva, Ivan Francia, Ramon Valls
  • Publication number: 20120088931
    Abstract: The invention is directed to a technique for effectively producing an amide compound suitable for use as a solvent or a detergent on a large scale and at low cost.
    Type: Application
    Filed: April 28, 2010
    Publication date: April 12, 2012
    Applicant: IDEMITSU KOSAN CO., LTD.
    Inventors: Hironori Tashiro, Yasushi Shiraki, Makoto Kashima
  • Publication number: 20110269981
    Abstract: Methods to pre-esterify primary polyols used in converting biobased oils, oil derivatives, and modified oils to highly functionalized esters, ester polyols, amides, and amide polyols.
    Type: Application
    Filed: December 31, 2009
    Publication date: November 3, 2011
    Applicant: BATTELLE MEMORIAL INSTITUTE
    Inventors: Herman Paul Benecke, Daniel B. Garbark, Bhima Rao Vijayendran
  • Publication number: 20110269982
    Abstract: Methods to convert fatty acids to highly functionalized esters, ester polyols, amides, and amide polyols. The products can be used to make polyurethane and polyester films and foams.
    Type: Application
    Filed: December 31, 2009
    Publication date: November 3, 2011
    Applicant: Battelle Memorial Institute
    Inventors: Herman Paul Benecke, Daniel B. Garbark, Bhima Rao Vijayendran
  • Patent number: 7985879
    Abstract: A novel process for the preparation of N-methyl-N-(2-[4-hydroxyphenyl]ethyl)-5-hydroxy-4-methoxy benzene carboxamide, which is useful as an intermediate in the synthesis of (?)-galantamine, comprises the reaction of a 5-hydroxy-4-methoxy benzoic acid derivative with N-methyl-N-(2-[4-hydroxyphenyl]ethyl) amine.
    Type: Grant
    Filed: April 2, 2008
    Date of Patent: July 26, 2011
    Assignee: Scinopharm Taiwan Ltd.
    Inventors: Lunghu Wang, Yung Fa Chen, Julian Paul Henschke
  • Publication number: 20110178305
    Abstract: The present invention relates to a process for the preparation of threo-3,4-epoxy-2-amino-1-substituted butane derivatives represented by general Formula I which comprises reacting compound of Formula III or salt thereof with an active ester of acid of Formula IV and treating the product thereof with base. The carbon atom bonded to the radical R3 in Formula I and IV is in the (R)-, (S)- or (R,S)-configuration. The compounds of Formula I and III, particularly in their (2S,3R) configuration are useful intermediates for the preparation of atazanavir bisulfate.
    Type: Application
    Filed: May 5, 2009
    Publication date: July 21, 2011
    Applicant: RANBAXY LABORATORIES LIMITED
    Inventors: Rakesh Singh, Prasad Yeragorla, Mahavir Singh Khanna, Mohan Prasad