Abstract: Novel FBPase inhibitors of the formula I are useful in the treatment of diabetes and other conditions associated with elevated blood glucose.

Abstract: A novel class of chiral phosphine ligands useful for producing catalyst for asymmetric reactions with general structure of Formula 1:

Abstract: A diazaphosphacycle may be synthesized by reacting a phosphine with a diimine and optionally one or more equivalents of an acid halide, a sulfonyl halide, a phosphoryl halide, or an acid anhydride in the substantial absence of O2 to form the diazaphosphacycle. The phosphine has the formula R1—PH2 where R1 is a substituted or unsubstituted aryl group, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted cycloalkyl group, or a substituted or unsubstituted ferrocenyl group.

Abstract: The application relates to diazaphospholidine compounds of Formula 1 and Formula 2: where: A and B are independently selected from C(R22R23) and C(R22R23)C(R24R25); R1, R2, R3, R4, R18, R19, R20, R21, R22, R23, R24 and R25 each may not be present and each may be independently selected from H, halide —OH, —SO2R26 (where R26 is selected from a group as defined for R22, R23, R24 and R25), —SH, —NO2, —NH2, ═O, ═S, straight chain, branched chain, cyclic, saturated, non-saturated, substituted or non-substituted alkyl, hydroalkyl, carboalkyl, alkoxy, amino, alkenyl, aryl and —CH2 Ar (where Ar is aryl or substituted aryl), preferably containing 1 to 6 carbons, or a silane containing 1 to 6 silicon atoms, wherein, where an R1, R2, R3, R4, R18, R19, R20, R21, R22, R23, R24 and/or R25 group is not present an unsaturated bond is formed; R5 and R17 are selected from H, —NH2, —OH, halide or a substituted or non-substituted strai

Abstract: This invention has an object of providing a flame retardant which advantageously has a high melting point and a low volatility and is unlikely to depress the inherent properties of resins. The flame retardant of the invention is a phosphazene compound crosslinked with a crosslinking group such as phenylene group, each of the crosslinking groups being interposed between the two oxygen groups left after the elimination of phenyl groups from the phosphazene compound, the amount of the phenyl groups in the crosslinked compound being 50 to 99.9% based on the total number of the phenyl groups in the phosphazene compound. The invention also provides a resin composition containing the flame retardant, and a molded article of the resin.

Abstract: Cyclic phosphazene compounds of formula (I): 1

Abstract: Chiral di-phosphonites and phosphhours diamides based on the ps-ortho disubstituted p-cyclophane skeleton are good ligands for transition metals, notably rhodium, iridium and ruthenium. Preferably, the transition metals are linked to the ligands by a diene compound chosen from 2,5-Norbornadiene (NBD) and 1,5-Cyclooctadiene (COD).

Abstract: Novel cyclo azaphospha hydrocarbons according to formula I are provided. The compounds are useful as metalloprotease inhibitors.

Abstract: This invention has an object of providing a flame retardant which advantageously has a high melting point and a low volatility and is unlikely to depress the inherent properties of resins. The flame retardant of the invention is a phosphazene compound crosslinked with a crosslinking group such as phenylene group, each of the crosslinking groups being interposed between the two oxygen groups left after the elimination of phenyl groups from the phosphazene compound, the amount of the phenyl groups in the crosslinked compound being 50 to 99.9% based on the total number of the phenyl groups in the phosphazene compound. The invention also provides a resin composition containing the flame retardant, and a molded article of the resin.

Abstract: This invention has an object of providing a flame retardant which advantageously has a high melting point and a low volatility and is unlikely to depress the inherent properties of resins. The flame retardant of the invention is a phosphazene compound crosslinked with a crosslinking group such as phenylene group, each of the crosslinking groups being interposed between the two oxygen groups left after the elimination of phenyl groups from the phosphazene compound, the amount of the phenyl groups in the crosslinked compound being 50 to 99.9% based on the total number of the phenyl groups in the phosphazene compound. The invention also provides a resin composition containing the flame retardant, and a molded article of the resin.

Abstract: A diazaphosphacycle may be synthesized by reacting a phosphine with a diimine and optionally one or more equivalents of an acid halide, a sulfonyl halide, a phosphoryl halide, or an acid anhydride in the substantial absence of O2 to form the diazaphosphacycle. The phosphine has the formula R1-PH2 where R1 is a substituted or unsubstituted aryl group, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted cycloalkyl group, or a substituted or unsubstituted ferrocenyl group.

Abstract: Novel cyclo azaphospha hydrocarbons according to formula I 1

Abstract: Anionic polymerization initiators useful in the preparation of polymers having a protected amine functional group. The amine functionality is part of a heterocyclic radical and includes a protecting group.

Abstract: A compound of the following formula: 1

Abstract: Bidentate phosphine ligands of the formula 1

Abstract: A process for preparing an organic pentavalent phosphorus compound comprising oxidizing an organic trivalent phosphorus compound with an aqueous hydrogen peroxide solution in the presence of an inorganic or organic base at a temperature of 0.degree. C. to 50.degree. C. to obtain the corresponding organic pentavalent phosphorus compound.

Abstract: A method is disclosed for deprotonating a compound comprising treating the compound with a base of the general formula: ##STR1## in the presence of a nitrile solvent; wherein R.sup.1, R.sup.2 and R.sup.3 are each individually H, (C.sub.1 -C.sub.15)alkyl, (C.sub.6 -C.sub.9)aryl, (C.sub.1 -C.sub.4)alkyl(C.sub.6 -C.sub.9)aryl, ((C.sub.1 -C.sub.4)alkyl).sub.3 Si, or (C.sub.6 -C.sub.9)aryl(C.sub.1 -C.sub.4)alkyl.

Abstract: Novel bleaches, a method for bleaching substrates using these materials and detergent compositions containing same are reported. The bleaches are phosphinoyl imines. Substrates such as fabrics may be bleached in an aqueous solution containing the phosphinoyl imines and a peroxygen compound.

Abstract: This invention relates to substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors, to pharmaceutical compositions comprising such compounds, and to methods of using these compounds for treating viral infection. A representative compound of the invention is the compound of formula: ##STR1## wherein R.sup.22 and R.sup.23 are allyl.

Abstract: This invention relates to compounds which are N-oxides and derivatives of chlorambucil and which, under certain conditions, (1) are stable in hypoxic and oxic cells, (2) are toxic in cells having varying degrees of hypoxia, and (3) show little toxicity to oxic cells. These compounds have the general formula set out below and are used to treat tumorous cells: ##STR1## wherein R is an alkyl, aryl, or derivatives thereof, such as CH.sub.3 OCH.sub.2 CH.sub.2 --; CH.sub.3 CH.sub.2 OCH.sub.2 CH.sub.2 --; C.sub.6 H.sub.5 OCH.sub.2 CH.sub.2 --; C.sub.6 H.sub.5 CH.sub.2 --; CH.sub.3 (CH.sub.2).sub.3 OCH.sub.2 CH.sub.

Abstract: Substituted 1,3,2,4-diazadiphosphetidines of formula I ##STR1## where preferably, R.sub.1 and R.sub.2 are branched alkyl or aryl, m and n are 1, p and q are 0, and YR.sub.3 and XR.sub.4 are substituted --O--phenyl or --N(alkyl).sub.2, are excellent stabilizers for organic materials, particularly polyolefins.

Abstract: A process for preparation of new or previously known pyrrol derivatives is provided. The process involves reacting a nitroalkane or a nitroalkene with an isocyanoacetate in the presence of a proprophosphatrane "super base" to prepare the pyrrol compounds. Through production of new pyrrol compounds, new pyrrol derivatives such as dipyrromethane and porphyrin may be synthesized. In addition, the high yields of pyrrol compounds produced according to the method of the invention provide for more efficient production of previously known dipyrromethane and porphyrin compounds. The invention further provides a mild, high yield process for de-esterification of esterified pyrrol and dipyrromethane compounds. The invention also provides a synthetic method for the production of high yields of oxazoles through reaction of an aryl halide or acid anhydride with an isocyanoacetate in the presence of a prophosphatrane "super base".

Abstract: Energetic nitramine containing cyclotriphosphazene which include 1,1,3,3,-tris-spiro(N,N'-dinitroethylenediamino)cyclotriphosphazene, 1,1-spiro(ethylenediamino)-3,3,5,5-bis-spiro(N,N'-dinitroethylenediamino)c yclotriphosphazene, 1,1,3,3-bis-spiro(N,N'-dinitroethylenediamino)-5,5-dichlorocyclotriphospha zene, 1,1,3,3-bis-spiro(N,N'-dinitroethylenediamino)-5,5-difluorocyclotriphospha zene, 1,1-spiro(N,N'-dinitroethylenediamino)-3,3,5,5-bis-spiro(ethylenediamino)c yclotriphosphazene, 1,1-spiro(ethylenediamino)-3,3-spiro(N,N'-dinitroethylenediamino)-5,5-dich lorocyclotriphosphazene, 1,1-spiro(ethylenediamino)-3,3-spiro(N,N'-dinitroethylenediamino)-5,5-difl uorocyclotriphosphazene, 1,1-spiro(N,N'-dinitroethylenediamino)-3,3,5,5-tetrachlorocyclotriphosphaz ene, and 1,1-spiro(N,N'-dinitroethylenediamino)-3,3,5,5-tetrafluorocyclotriphosphaz ene, which can be used in explosive compositions.

Abstract: Hydrolytically and thermooxidatively stable monophospha-s-triazines prepared by reaction of octafluoroisobutylene epoxide with an acid fluoride followed by transformation of the resultant product into an amide, then into a nitrile, reacting the nitrile with ammonia and reacting the imidoylamidine resulting from the previous steps with di-aryltrihalophosphorane to produce mono-phospha-s-triazines that are useful as antioxidant - anticorrosion agents for perfluoroalkylether fluids are disclosed.

Abstract: A process for preparing isocyanates comprising (a) contacting carbon dioxide and a primary amine in the presence of an aprotic organic solvent and a phosphazene compound or a mixture of a phosphazene compound and an organic, nitrogenous base selected from the group consisting of guanidine compounds, amidine compounds, tertiary amines, pyridine and mixtures thereof to produce the corresponding ammonium carbamate salt, and (b) reacting the ammonium carbamate salt with an electrophilic or oxophilic dehydrating agent to produce the corresponding isocyanate. A second embodiment comprises recovering the ammonium carbamate salt of step (a) prior to reacting the ammonium carbamate salt with an electrophilic or oxophilic dehydrating agent in the presence of an aprotic organic solvent and a phosphazene compound or a mixture of a phosphazene compound and an organic, nitrogenous base selected from the group consisting of guanidine compounds, amidine compounds, tertiary amines, pyridine and mixtures thereof.

Abstract: The present invention provides an antistatic composition comprising a binder, a cyclic phosphazene, and a salt that complexes with the cyclic phosphazene. The cyclic phosphazene has the general formula ##STR1## wherein x is 3 or 4.

Abstract: Novel substituted phosphazene compounds are disclosed having the formula ##STR1## wherein w, x, y and z are integers the sum of which is from 3 to 6 with the proviso that w is at least 1 but equal to or less than (w+x+y+z)-1, x is from 1 to 5, y and z are from 0 to 2;R.sub.1 and R.sub.2 are the same or different and are C.sub.1 to C.sub.6 linear or branched alkyl;R.sub.3 is an unsubstituted or substituted aryl and n is 0 or an integer from 2 to 6; Q is --O--, ##STR2## --NR-- or --S--; Ar is ##STR3## R' and R" are the same or different and are C.sub.1 to C.sub.6 linear or branched alkyl, with the proviso that R" can also be hydrogen, wherein R.sub.1 and R.sub.2 are the same or different C.sub.1 to C.sub.4 linear or branched alkyl group and n is 0 or an integer from 2 to 6. These compounds display good solubilities in both organic and aqueous systems. Accordingly, they act as antioxidants in adhesive, sealant and coating compositions.

Abstract: Phosphinamides are prepared by the action of an organic halide on an oxazaphospholidine. Depending upon the configuration desired for the stereoisomer to be obtained, an oxazaphospholidine is utilized which has been derived from a (+) or (-) optically-active amino-alcohol. These phosphinamides are useful for the preparation of phosphinates, in particular optically-active phosphinates of known absolute configuration; for this, the phosphinamide is subjected to alcoholysis.

Abstract: The present invention is directed to a process for the production of polyurethanes using catalysts based on triamino(imino)phosphoranes corresponding to formulas I, II or III ##STR1## wherein R, R', R" and R"' represent hydrocarbon substituents andn and m may be the same or different and represent 0, 1 or 2.The present invention also relates to certain of the triamino(imino)phosphoranes used as catalysts.

Abstract: Prophosphatrane compounds of the formula ##STR1## are disclosed. These compounds are strong Lewis bases and are useful as proton abstracting reagents.

Abstract: The present invention provides an antistatic composition comprising a binder, a cyclic phosphazene, and a salt that complexes with the cyclic phosphazene. The cyclic phosphazene has the general formula ##STR1## wherein x is 3 or 4.

Abstract: New chemical product, constituted by an organic phosphorus compound of the structure ##STR1## where Q is an N or O atom, T is an alkylene or arylene, possibly carrying substituents, or not existing, while R.sup.1 to R.sup.7, the same or different, are H or aliphatic, cycloaliphatic and/or arylic hydrocarbon radicals, possibly substituted, R.sup.3 not existing when Q is oxygen.This product is used as an intermediate in the preparation of different derivatives of phosphinous acid.

Abstract: The invention relates to azaphospholenes of the type ##STR1## wherein R.sub.1 and R.sub.2 may be alkyl, aryl and aralkyl groups, processes for preparing same and the use thereof.

Abstract: This invention relates to a process for producing phosphonitrile oligomers containing maleimido phenoxy groups.

Abstract: Novel pesticidally active cyclic malonylphosphonic diamides of the formula ##STR1## in which X.sup. represents O or S,R.sup.1 represents alkyl, alkenyl, alkinyl, cycloalkyl, aryl or heteroaryl, each of which can be optionally substituted,R.sup.2 represents hydrogen, alkyl, aryl or aralkyl,R.sup.3 represents hydrogen, alkyl, aryl or aralkyl, andR.sup.

Abstract: Compounds of the formula ##STR1## in which R.sub.1 and R.sub.2 denote alkyl, OH, CF.sub.3 or cyanoethyl, A preferably denotes --COOH, R.sub.3 denotes inter alia alkoxycarbonylalkoxy, fairly high-molecular (>C.sub.12) alkoxy, alkylcarbonylalkoxy or nitrobenzyloxy, are valuable herbicides and growth regulators.

Abstract: 4-Aminophenoxy cyclotriphosphazenes are reacted with maleic anhydride to produce maleamic acids which are converted to the maleimides. The maleimides are polymerized. By selection of starting materials (e.g. hexakis amino or trisaminophenoxy-trisphenoxy-cyclotriphosphazenes), selection of molar proportions of reactants, use of mixtures of anhydrides and use of dianhydrides as bridging groups a variety of maleimides and polymers are produced. The polymers have high limiting oxygen indices, high char yields and other useful heat and fire resistant properties making them useful as, for example, impregnants of fabrics.

Abstract: A long-acting, local anesthetic, comprising a polymeric phosphazene backbone, and certain radicals having local anesthetic activity and an amino functional group on the ring of said radical through which said radical is covalently attached to the phosphazene backbone by a phosphorous-nitrogen single bond is disclosed along with medicaments containing such anesthetics. The radicals employed are 2-amino-4-picoline, benoxinate, naepaine and phenacaine.

Abstract: A process is provided for the preparation of diaryl methylphosphonates through the reaction of triaryl phosphites with methanol in the presence of a catalytic quantity of methyl iodide. The reaction is conducted at a temperature of from about 170.degree. C. to about 250.degree. C. New and useful derivatives are produced by reaction of the diaryl methylphosphonates with polyols or amines.

Abstract: Highly fire resistant composites or laminates particularly applicable as structural components in aircraft, e.g. in the engine nacelle, as part of the acoustic panel-fire wall structure, and capable of withstanding a 2,000.degree. F. flame temperature, comprising incorporating an additive in the form of a polymeric phosphorylated amide, into a resin, e.g., a polyimide or an epoxy resin, such additive being soluble in the resin. The resulting resin containing the additive is then applied to or impregnated into a substrate such as glass fiber cloth or graphite fiber, to form a composite structure which is then cured. The resulting cured composite when subjected to high temperatures of the order of, e.g., a 2,000.degree. F. flame temperature, forms a resin char of reduced thermal conductivity which holds the fibers of the laminate together and maintains the structural stability and integrity of the laminate.

Abstract: This invention concerns itself with a novel class of dihalodiphospha-s-triazines as exemplified by the compound 1,3-bis[phenylchloro-phospha]-5-perfluoro-n-heptyl-2,4,6-triazines as well as their thio and azido substituted derivatives.

Abstract: This invention concerns itself with a class of novel dihalo-substituted monophospha-s-triazines as exemplified by the compounds 1-dichlorophospha-3,5-bis(perfluoro-n-heptyl)-2,4,6-triazine and 1-dichlorophospha-3,5-bis[C.sub.3 F.sub.7 OCF(CF.sub.3)CF.sub.2 OCF(CF.sub.3)]-2,4,6-triazine, as well as their thio and azido derivatives.

Abstract: Substituted tetrahydrobenzodiazaphosphorindiones or tetrahydropyridodiazaphosphorindiones, intermediates therefore, synthesis thereof, said compounds being useful herbicides.

Abstract: A long-acting, local anesthetic, comprising a polymeric phosphazene backbone, and 2-amino-4-picoline radical having local anesthetic activity and an amino functional group on the ring of said radical through which said radical is covalently attached to the phosphazene backbone by a phosphorous-nitrogen single bond is disclosed along with medicaments containing such anesthetics.

Abstract: Polyester polymers and copolyester polymers incorporating flame retardant amounts of cyclotri (or tetra) phosphazenes. These cyclotri (or tetra) phosphazenes can be added at the start of ester interchange, prior to, for example polycondensation and conventional melt spinning, or if desired, after polycondensation but before melt spinning. Specific examples of cyclotriphosphazenes and cyclotetraphosphazenes are hexa(dialkylphosphinylmethyleneoxy)cyclotriphosphazene, octa(dialkylphosphinylmethyleneoxy)cyclotetraphosphazene, tris(alkylphosphinyldimethyleneoxy)cyclotriphosphazene, tetra(alkylphosphinyldimethyleneoxy)cyclotetraphosphazene, hexa(dialkylphosphinylmethylene)cyclotriphosphazene, and octa(dialkylphosphinylmethylene)cyclotetraphosphazene.

Abstract: The present invention relates to novel polychlorophosphazenes and to the process for their preparation.These polychlorophosphazenes of the general formula:Cl.sub.2 (O) P [NPCl.sub.2 ].sub.n Clare prepared by the polycondensation of P trichloro-N dichlorophosphoryl-monophosphazene with the controlled release of POCl.sub.3 according to the equation: ##STR1## The novel polychlorophosphazenes so obtained are useful as antiflame materials, as coatings, as fertilizers, etc. . . .

Abstract: This disclosure relates to novel substituted benzazaphospholes and to methods of preparing such compounds. This invention further relates to herbicidal compositions containing such benzazaphospholes and to herbicidal methods employing such compounds and compositions. The compounds of the present invention are members of a class of bicyclic hetero compounds containing only one phosphorus-nitrogen bond and different moieties bonded to the phosphorus and nitrogen.

Abstract: A method for preparing unsymmetrical diphosphatetraazacyclooctatetraenes and the novel products produced thereby. The synthesis involves an interaction between an imido-tetraaryl-diphosphinic acid trihalide and a perfluorinated imidoylamidine in the presence of an acid acceptor.

Abstract: A method for synthesizing symmetrical diphosphatetraazacyclooctatetraenes and the products produced thereby. The synthesis involves effecting a reaction between a diaryltrihalophosphorane of a perfluoroalkyl amidine in the presence of an acid acceptor.

Abstract: This invention relates to substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors, to pharmaceutical compositions comprising such compounds, and to methods of using these compounds for treating viral infection. A representative compound of the invention is the compound of formula: wherein R22 and R23 are allyl.