Abstract: The present invention relates to a two-step process for the preparation of guanidinium salts of the formula (1), where the substituents R have a meaning indicated in Claim, and A? is a sulfonate, alkyl- or arylsulfate, hydrogensulfate, imide, methanide, carboxylate, phosphate, phosphinate, phosphonate, borate, thiocyanate, perchlorate, fluorosilicate or nitrate, and to intermediate compounds from this process.

Abstract: The invention relates to a novel method for producing robenidine and salts thereof of the general formula wherein X denotes a halogen atom. The method uses hydrazine hydrate and a cyano compound YCN as the starting materials, which are first reacted to projuce a diaminoguanidine of the general formula wherein Y denotes a halogen atom or tosyl. This diaminoguanidine is then converted directly, without isolation, by reacting with a p-halobenzaldehyde of the general formula IV to produce the robenidine and salts thereof of general formula I.

Abstract: Cyanogen chloride and dimethylamine are reacted in a water/organic solvent system. The organic solvent is immiscible with water. After the completion of reaction, the water-immiscible organic solvent is distilled away from the reaction product solution to carry out the subsequent synthesis of 1,1,3,3-tetramethylguanidine in an aqueous system.

Abstract: A guanidine derivative represented by formula (1), (2), (3) or its acid addition salt and a production process thereof wherein each of A and B is a C2-C8 alkylene, D is a single bond, —CO— or a C1-C6 alkylene, E is H, a lower alkyl or the like, m is 1 to 6, n is 0 to 6 and R1 is H, a lower alkyl or the like, 1 is 1 to 10 and G is H, —OH or the like and a skin cosmetic containing the same. It can exert excellent keratin layer softening effect continuously for a long period of time.

Abstract: Substituted guanidine derivatives of the formula I ##STR1## are prepared by reacting calcium cyanamide with a primary or secondary amino carboxylic acid or a primary or secondary amino sulfonic acid or their derivatives of the formula II ##STR2## where the substituents R.sup.1 and R.sup.2 have the meanings explained in the description.

Abstract: An antimicrobial composition comprising the formula ##STR1## wherein R is an alkyl group having a distribution of carbon atoms from about eight to eighteen carbon atoms and wherein from about 40 to 60 weight % of the alkyl group having about twelve carbon atoms and wherein X is hydrogen or a halide is disclosed. The antimicrobial composition is storage stable below about 5.degree. C. and, further, preferably, also has a flash point above about 38.degree. C. A process for making this antimicrobial composition is disclosed resulting in an antimicrobial composition comprising from about 25 to 35 weight % of the alkyl guanidine halide salt of the above formula, from about 10 to 60 weight % of a solvent and from about 10 to 65 weight % water.

Abstract: Diarylguanidines can be isolated from the crude melt from the reaction of arylamines and cyanogen chloride in excellent quality and yield by dissolving the hot melt in water, extracting this solution with at least one polar, water-insoluble, organic compound, and precipitating from the purified aqueous solution the diarylguanidine by adding alkali metal hydroxide.

Abstract: Guanidine hydrochloride is produced from cyanogen chloride in a new manner. The cyanogen chloride is reacted with ammonia in the absence of a solvent at a temperature of about 140.degree. to 220.degree. C. It is advantageous to add an ammonium salt at the beginning of the reaction and to use ammonia in at least stoichiometrical amounts.