O-esters (i.e., H Of Oxime -oh Replaced By Ester Forming Group) Patents (Class 564/254)
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Patent number: 5650444Abstract: A compound of the following structure: ##STR1## wherein, when R.sub.8 =H: R.sub.1 =alkyl, cycloalkyl, arylalkyl, aryl;R.sub.2 =cycloalkyl, aryl, C.sub.3 -C.sub.10 alkyl;X,Y=O, S(O).sub.n, NH;Z=CHO, CO.sub.2 R.sub.3, CONHR.sub.4 R.sub.5, CN, COR.sub.6, H, halo, HCN, NHCONR.sub.4 R.sub.5, CONR.sub.4 OR.sub.5, CONR.sub.4 NR.sub.5 R.sub.6, 1-tetrazole, S(O).sub.n OH, S(O).sub.n NR.sub.3 R.sub.4, C.dbd.NOH, C(.dbd.N(OH)NH.sub.2, OCONR.sub.7 R.sub.6, P(O)(OR.sub.4).sub.2, C(.dbd.N(YR.sub.3))R.sub.4, NH.sub.2, SH, OH, OS(O).sub.2 R.sub.3, C(.dbd.NYC(.dbd.O)R.sub.3)R.sub.4, C(O)CO.sub.2 R.sub.3, C(O)CONR.sub.3 R.sub.4, CH(OH)CO.sub.2 R.sub.3, CHFCO.sub.2 R.sub.3, CF.sub.2 CO.sub.2 R.sub.3, CH(OH)CONR.sub.3 R.sub.4, CF.sub.2 CONR.sub.3 R.sub.4, C.dbd.NNH.sub.2, C(.dbd.NOC(.dbd.O)R.sub.3)R.sub.4, C(.dbd.NNHC(.dbd.O)R.sub.3)R.sub.4, C(.dbd.NOH)R.sub.3, C(.dbd.NNR.sub.3)R.sub.4, NHC(.dbd.O)R.sub.6 or C(O)CONH.sub.2 ;R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.Type: GrantFiled: May 25, 1995Date of Patent: July 22, 1997Assignee: American Home Products CorporationInventors: Thomas J. Caggiano, Joseph Prol, Jr.
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Patent number: 5548078Abstract: A fungicidal composition for agricultural use, which comprises a compound of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are each hydrogen, lower alkyl or cyclo(lower)alkyl; R.sup.3 is lower alkyl or cyclo(lower)alkyl; R.sup.4 and R.sup.5 are each hydrogen, lower alkyl, lower alkoxy, halogen-substituted lower alkyl, lower alkyl-substituted silyl, halogen or nitro; A represents an unsaturated hydrocarbon group, a halogen-substituted unsaturated hydrocarbon group, a phenyl group or a heterocyclic group, among which the phenyl group and the heterocyclic group may be optionally substituted with not more than three substituents; and Z is --CH.sub.2 --, --CH(OH)--, --CO--, --O--, --S--, --NR-- (R being hydrogen or lower alkyl), --CH.sub.2 CH.sub.2 --, --CH.dbd.CH--, ##STR2## --CH.sub.2 O--, --CH.sub.2 S--, --CH.sub.2 SO--, --OCH.sub.2 --, --SCH.sub.2 -- or --SOCH.sub.2 --.Type: GrantFiled: December 20, 1994Date of Patent: August 20, 1996Assignee: Shionogi Seiyaku Kabushiki KaishaInventors: Yoshio Hayase, Takahiro Kataoka, Hideyuki Takenaka, Mitsuhiro Ichinari, Michio Masuko, Toshio Takahashi, Norihiko Tanimoto
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Patent number: 5276187Abstract: This invention relates to novel ketoxime carbonates and a process for the synthesis of ketoxime carbonates generally. Ketoxime carbonates are useful in a variety of applications. They may be used for example as pesticides, pharmaceuticals, weed control agents and dye stuff intermediates.Type: GrantFiled: August 23, 1991Date of Patent: January 4, 1994Assignee: AlliedSignal Inc.Inventors: Halasya Ramanathan, Chempolil T. Mathew
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Patent number: 5254584Abstract: Certain N-acetonylbenzamides exhibit low phytotoxicity and are useful for control of a wide range of fungi, including phytopathogenic fungi of the classes Oomycetes, Ascomycetes, Deuteromycetes and Basidiomycetes.Type: GrantFiled: December 18, 1992Date of Patent: October 19, 1993Assignee: Rohm and Haas CompanyInventors: Enrique L. Michelotti, Robert R. Raney, David H. Young
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Patent number: 5206406Abstract: A process for preparing N-ethylhydroxylamine hydrochloride which comprises reacting hydroxylamine hydrochloride with di-t-butyl dicarbonate in the presence of a base thus producing N,O-bis-[(1,1-dimethylethoxy)carbonyl]-hydroxylamine, alkylating said reaction product and then cleaving with acid the tert-butyloxy carbonyl (BOC) portion of the alkylated product.Type: GrantFiled: August 21, 1992Date of Patent: April 27, 1993Assignee: Hoechst-Roussel Pharmaceuticals Inc.Inventor: George E. Lee
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Patent number: 5147879Abstract: Hydroximic acid derivatives of the formula ##STR1## These compounds are useful for treating diabetes angiopathy.Type: GrantFiled: June 28, 1990Date of Patent: September 15, 1992Assignee: Biorex Kutato-Fejleszto KftInventors: Peter L. Nagy, Bela Balazs, Maria Boross, Jeno Szilbereky, Gizella Zsila, Lajos braham, Gyorgy Blasko, Bela Gachalyi, Attila Almasi, Gabor Nemet
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Patent number: 5134167Abstract: 1-Azabutadienes of the formula ##STR1## where R.sup.1 and R.sup.2 are each phenyl, biphenyl, naphthyl or pyridyl, and these radicals may be substituted, or are each alkyl which is unsubstituted or substituted, R.sup.3 is substituted or unsubstituted phenyl or a radical OR.sup.4, where R.sup.4 is hydrogen, alkyl or an aromatic or aliphatic acyl group, or R.sup.3 is a radical NHR.sup.5, where R.sup.5 is hydrogen, substituted or unsubstituted phenyl, or the carbamide group, and fungicidal agents containing these compounds.Type: GrantFiled: July 11, 1990Date of Patent: July 28, 1992Assignee: BASF AktiengesellschaftInventors: Manfred Lauer, Bernhard Zipperer, Norbert Goetz, Gisela Lorenz, Eberhard Ammermann
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Patent number: 5095087Abstract: Disclosed are certain ketoxime-blocked polyisocyanates and polyester compositions containing the ketoxime-blocked polyisocyanates. Also disclosed are thermosetting powder coating compositions comprising one or more polyesters and at least one of the ketoxime-blocked polyisocyanates and articles coated with the powder coating compositions.Type: GrantFiled: February 25, 1991Date of Patent: March 10, 1992Assignee: Eastman Kodak CompanyInventors: J. Stewart Witzeman, Glenn C. Jones
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Patent number: 5041663Abstract: The invention relates to novel oxime ethers of the formula I ##STR1## wherein R.sub.1 is hydrogen, halogen, lower alkyl, lower haloalkyl, lower alkoxy, lower haloalkoxy, lower alkylthio, lower haloalkylthio, lower alkylsulfinyl, lower alkylsulfonyl, lower haloalkylsulfinyl, lower haloalkylsulfonyl or nitro, each of R.sub.2 and R.sub.3 is hydrogen, halogen, lower alkyl, lower alkoxy or lower haloalkoxy, and Q is an unsubstituted or substituted lower alkyl, lower alkenyl, lower alkynyl or cycloalkyl group, a lower alkanoyl radical, an aliphatic, cycloaliphatic, aromatic or heterocyclic acyl radical which may be substituted or unsubstituted, a carbonyl or thiocarbonyl radical, an aryl or aralkyl radical, an acylimidomethyl radical, a phthalimidomethyl radical or a heterocyclic radical.These compounds are able to act as antidotes or safeners for protecting cultivated plants from the phytotoxic action of aggressive herbicides.Type: GrantFiled: December 11, 1990Date of Patent: August 20, 1991Assignee: Ciba-Geigy CorporationInventors: Henry Martin, Urs Fricker
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Patent number: 4946865Abstract: A compound of the formula: ##STR1## wherein X is a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.3 alkyl group or a C.sub.1 -C.sub.3 alkoxy group and Y is a hydrogen atom, a halogen atom, a cyano group, a formyl group, an ethylene-dioxymethyl group, a hydroxyl group, a hydroxymethyl group or a group of either one of the formulas: --CH.dbd.N--OR.sup.1, --COOR.sup.2, --CONH--R.sup.2 and --CH(OR.sup.3).sub.2 in which R.sup.1 is a hydrogen atom, a C.sub.1 -C.sub.3 alkyl group, a C.sub.3 -C.sub.5 alkenyl group, a C.sub.3 -C.sub.5 alkynyl group, a halo(C.sub.3 -C.sub.5)alkynyl group or a C.sub.1 -C.sub.3 alkyl group substituted with a phenyl group or a cyano group, R.sup.2 is a hydrogen atom, a C.sub.1 -C.sub.3 alkyl group, a C.sub.3 -C.sub.5 alkenyl group or a C.sub.3 -C.sub.5 alkynyl group and R.sup.3 is a C.sub.1 -C.sub.Type: GrantFiled: December 24, 1986Date of Patent: August 7, 1990Assignee: Sumitomo Chemical Company, LimitedInventors: Junya Takahashi, Shigeko Nakamura
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Patent number: 4910221Abstract: Pesticidal novel .alpha.-methylsulphonyl-benzaldoxime derivatives of the formula ##STR1## in which R represents alkyl, alkoxy, halogenoalkyl, halogenoalkoxy or alkenyloxy, aryl or aryloxy which is in each case optionally monosubstituted to polysubstituted by identical or different substituents, aralkyloxy which is optionally monosubstituted to polysubstituted in the aryl radical by identical or different substituents, cycloalkyloxy which is optionally monosubstituted to polysubstituted by identical or different substituents, or a heterocyclic ring which is optionally monosubstituted to polysubstituted by identical or different substituents,X represents hydrogen or halogen, andHal represents halogen.Type: GrantFiled: April 8, 1988Date of Patent: March 20, 1990Assignee: Bayer AktiengesellschaftInventors: Christa Fest, Gerd Hanssler, Wilhelm Brandes
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Patent number: 4897424Abstract: Novel substituted aryloxyphenyl-thioureas, -isothioureas and -carbodiimides of formula I ##STR1## in which R.sub.1 represents C.sub.1 -C.sub.12 alkyl, C.sub.1 -C.sub.12 alkyl mono- or poly-substituted by halogen and/or by C.sub.1 -C.sub.6 alkoxy, C.sub.3 -C.sub.8 cycloalkyl, C.sub.3 -C.sub.8 cycloalkyl mono- or poly-substituted by C.sub.1 -C.sub.3 alkyl, or C.sub.3 -C.sub.8 cycloalkyl-C.sub.1 -C.sub.4 alkyl;R.sub.2 represents hydroben or C.sub.1 -C.sub.5 alkyl;R.sub.3 represents a C.sub.1 -C.sub.5 alkyl or C.sub.5 -C.sub.6 cycloalkyl;R.sub.4 represents hydrogen or methyl;R.sub.5 represents a --CH.dbd.CH--.sub.2, --CH.sub.2 --.sub.3 or --CH.sub.2 --.sub.4 bridge in the 2,3- or 3,4-position;Z represents --NH--CS--NH--, --N.dbd.C(SR.sub.6)--NH-- or --N.dbd.C.dbd.N-- andR.sub.6 represents C.sub.1 -C.sub.Type: GrantFiled: June 9, 1988Date of Patent: January 30, 1990Assignee: Ciba-Geigy CorporationInventors: Manfred Boger, Jozef Drabek, Josef Ehrenfreund
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Patent number: 4894461Abstract: 3-(.gamma.-chloropropyl)-6-fluoro-1,2-benzisoxazole is a compound useful in preparing compounds having a neuroleptic utility.Type: GrantFiled: February 27, 1986Date of Patent: January 16, 1990Assignee: Hoechst-Roussel Pharmaceuticals, Inc.Inventors: Larry Davis, Richard C. Effland
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Patent number: 4886832Abstract: Fungicidally active benzaldoxime derivatives of the formula ##STR1## in which R represents alkyl, alkoxy, halgenoalkyl, halogenoalkoxy or alkenyloxy, or aryl or aryloxy, in each case optionally mono- or polysubstituted by identical or different substituents, aralkyloxy which is optionally mono- or polysubstituted in the aryl radical by identical or different substituents, or represents cycloalkoxy which is optionally mono- or polysubstituted by identical or different substituents, or represents a heterocyclic radical which is optionally mono- or polysubstituted by identical or different substituents,R.sup.1 represents hydrogen, halogen, alkyl or alkoxy,R.sup.2 represents hydrogen, alkyl or halogenoalkyl,R.sup.3 represents hydrogen or halogen,R.sup.4 represents halogen andR.sup.5 represents hydrogen or halogen.Type: GrantFiled: March 10, 1988Date of Patent: December 12, 1989Assignee: Bayer AktiengesellschaftInventors: Christa Fest, Kurt Findeisen, Wilhelm Brandes, Stefan Dutzmann, Gerd Hanssler, Paul Reinecke
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Patent number: 4879314Abstract: Dihaloformaldoximes of the formula: ##STR1## wherein R, X, X.sup.1 and Y are as defined herein having biocidal, fungicidal and pesticidal activity are disclosed.Type: GrantFiled: January 8, 1986Date of Patent: November 7, 1989Inventor: Adam C. Hsu
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Patent number: 4816487Abstract: New 1-(2-hydroxylaryl)-alkane-1-on-oximes, procedure for their preparation, and their applicability to pharmaceutical preparations. One purpose is to develop 1-(2-hydroxyaryl)-alkane-1-on-oximes with desirable pharmacological properties. The new compounds of Formula I ##STR1## are characterised by pharmacologically valuable properties, in particular by anti-asthmatic, anti-anaphylactic, antiphlogistic, antihypertensive, spasmolytic, antirheumatic, and antithrombotic, potentials and are applicable in human and veterinary medicine to therapy of asthma bronchiale and other allergic diseases, various kinds of inflammatory and rheumatic diseases, and thrombosis.Type: GrantFiled: March 14, 1985Date of Patent: March 28, 1989Assignee: Humboldt-Universitaet zu BerlinInventors: Tankred Schewe, Hartmut Kuehn, Joerg Beger, Grupe, Renate, Rapoport, Samuel M., Hans-Joachim Binte, deceased, Juergen Slapke
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Patent number: 4766152Abstract: The present invention relates to novel oximes of the formula ##STR1## wherein U is one of the radicals ##STR2## and R.sub.1 is C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.5 alkenyl, C.sub.3 monohaloalkenyl, C.sub.3 -C.sub.5 alkynyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.2 -C.sub.5 alkoxyalkyl, C.sub.2 -C.sub.5 alkylthioalkyl, or benzyl, which is unsubstituted or substituted at the nucleus,R.sub.2 and R.sub.3 are each independently of the other hydrogen or C.sub.1 -C.sub.3 alkyl,R.sub.4, R.sub.5 and R.sub.6 are each independently of one another hydrogen, halogen, C.sub.1 -C.sub.4 alkyl, C.sub.2 -C.sub.4 haloalkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 haloalkoxy or nitro,n is 0 or 1,X is oxygen, sulfur or ##STR3## Y is oxygen, sulfur ##STR4## and Z is oxygen or sulfur;with the proviso that X and Y are not simultaneously oxygen and/or at least one of the radicals R.sub.4, R.sub.5 and R.sub.6 has a meaning other than hydrogen if R.sub.1 is a C.sub.1 -C.sub.Type: GrantFiled: May 1, 1986Date of Patent: August 23, 1988Assignee: Ciba-Geigy CorporationInventor: Friedrich Karrer
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Patent number: 4746678Abstract: The invention relates to new phenanthrene derivatives wherein R stand for C.sub.1-10 alkylamino; C.sub.1-10 alkylthio; C.sub.1-5 alkoxy; or phenyl or phenylamino, the two latter groups being optionally substituted on the phenyl ring by one or more identical or different C.sub.1-4 alkyl, C.sub.1-4 alkoxy, nitro, amino, cyano and/or halogen substituent(s) .The compounds of the present invention possess valuable fungicidal properties and may be used in agriculture, horticulture and therapy as active ingredient of fungicidal or antifungal compositions.The compounds of the general Formula I ##STR1## may be prepared by acylating 9,10-phenanthrene-dione-9-oxime or an alkali or alkali earth metal salt thereof.Type: GrantFiled: June 4, 1986Date of Patent: May 24, 1988Assignee: EGIS GyoryszergyarInventors: Pal Benko, Tibor Zsolnai, Marta Kininczky, Laszlo Pallos, Iren Zsolnai nee Csillag, Peter Tetenyi, Jeno Bernath
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Patent number: 4736055Abstract: Oxime sulfonates of formula I ##STR1## wherein Y is a polymerizable unsaturated group or epoxide group or an --OH, --NHR.sup.5, --COOH, COOR.sup.6, --COCl, --CH.sub.2 Hal, --SO.sub.2 Cl or --NCO group, Z is an (x+y)-valent connecting member, R.sup.1 and R.sup.2 are monovalent organic radicals, m is 0 or 1, x is 1 or 2 and y is 1 or 2, can be converted into polymers which can be thermally or photochemically dissociated to form free sulfonic acid groups. Said polymers can therefore be used as photoresists which can be developed with aqueous alkalis.Type: GrantFiled: April 11, 1986Date of Patent: April 5, 1988Assignee: Ciba-Geigy CorporationInventors: Kurt Dietliker, Werner Rutsch, Godwin Berner, Max Hunziker, Christopher G. Demmer
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Patent number: 4673692Abstract: A compound represented by the formula ##STR1## wherein R.sup.1 represents a hydroxyl group, an alkanoyloxy group or a group of the formula ##STR2## in which R.sup.2 represents a hydrogen atom or a lower alkyl group, and R.sup.3 represents a hydrogen atom, a lower alkyl group, an alkanoyl group, a phenyl group, a carbamoyl group or a thiocarbamoyl group, or a salt thereof.The said compound can be prepared by reacting a compound represented by the formula ##STR3## with a compound of the formulaNH.sub.2 --R.sup.1 (III)wherein R.sup.1 is as defined hereinabove, or a salt thereof, and as required, alkanoylating the resulting compound of formula (I) in which R.sup.1 represents a hydroxyl group or an amino group, and as required, converting the resulting compound of formula (I) in which R.sup.1 is the group ##STR4## into its salt, and is useful for the treatment of inflammation, pain or rheumatism.Type: GrantFiled: October 18, 1985Date of Patent: June 16, 1987Assignee: Teikoku Hormone Mfg. Co., Ltd.Inventors: Yasushi Suzuki, Yukio Hasegawa, Michitaka Sato, Morinobu Saito, Norio Yamamoto, Katsuhiko Miyasaka, Takashi Mikami, Katsuhiko Miyazawa
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Patent number: 4581365Abstract: The invention relates to new trichloroacryloyl oxime compounds of the general formula (I) ##STR1## wherein each of R.sup.1 and R.sup.2 represents a hydrogen atom, a lower alkyl group, a benzyl group, a benzylthio group, a lower alkylthio group, a cycloalkyl group, a halogen atom, a styryl group, a halogenophenylthio group, a naphthyl group, or a phenyl group which may optionally be substituted by at least one substituent selected from the class consisting of a halogen atom, a nitro group, a lower alkyl group, a lower alkoxy group, a phenoxy group, a benzyloxy group, a lower alkylthio group, a thiocyanato group, a di-lower alkylamino group, a halogenopyridyloxy group and a methylenedioxy group, or R.sup.1 and R.sup.2, together with the carbon atom to which they are bonded, may form an aliphatic ring, said ring being optionally substituted by at least one methyl group, and their use as fungicides.Type: GrantFiled: December 2, 1983Date of Patent: April 8, 1986Assignee: Nihon Tokushu Noyaku Seizo K.K.Inventors: Yasuo Yamada, Junichi Saito, Toshio Gotoh, Osamu Katsumata, Shinji Sakawa
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Patent number: 4559172Abstract: This invention relates to a novel acylation process which comprises using as the acylating agent an o-hydroxy-substituted aromatic oxime ester represented by the general formula (I) ##STR1## and mixing said acylating agent with an amine substance represented by the general formula (III) ##STR2## to form a compound represented by the general formula (IV) ##STR3##Type: GrantFiled: May 1, 1984Date of Patent: December 17, 1985Assignee: Nitto BosekiInventors: Ikuo Hayashi, Keizo Ogihara, Tadao Itikawa, Kiyoshi Shimizu
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Patent number: 4515616Abstract: Triazolyl ketone-oximes and triazolyl dioximes of the general formula I ##STR1## where Ar is an aryl radical from the group comprising biphenylyl, naphthyl and phenyl, which radical can be substituted by halogen, nitro, cyano or trifluoromethyl, by alkyl, alkoxy or alkenyl, each of not more than 5 carbon atoms or by phenoxy, andn is 1 or 2,X is oxygen or .dbd.N--OR.sup.3, R.sup.3 being hydrogen, unsubstituted, halogen-substituted or alkoxy-substituted alkyl, alkenyl or alkynyl, each of not more than 5 carbon atoms, or benzyl which is unsubstituted or substitutedby halogen, nitro, cyano or trifluoromethyl, or by alkyl or alkoxy, each of not more than 4 carbon atoms, or is --CO--R.sup.4,R.sup.4 being unsubstituted, halogen-substituted or alkoxy-substituted alkyl of not more than 5 carbon atoms, an aromatic radical or --NH--R.sup.5, R.sup.5 being alkyl or not more than 4 carbon atoms or an aromatic radical,R.sup.Type: GrantFiled: May 27, 1983Date of Patent: May 7, 1985Assignee: BASF AktiengesellschaftInventors: Costin Rentzea, Wolfgang Spiegler, Johann Jung
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Patent number: 4497745Abstract: Novel oxime ethers and oxime esters of the formula I given herein have various advantageous effects with regard to stimulation of plant growth, particularly in the early stage of development of the plant. Furthermore, such compounds have the property of rendering, in the sense of an antidote action, agricultural chemicals which would otherwise damage the plants (phytotoxic chemicals) more compatible with the cultivated plants. Herbicides that are insufficiently selective can be used for example in the presence of such oxime derivatives in specific cultivated crops for combating weeds, without disadvantageous consequences for the cultivated plants.Type: GrantFiled: September 30, 1982Date of Patent: February 5, 1985Assignee: Ciba-Geigy CorporationInventor: Henry Martin
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Patent number: 4491469Abstract: This application discloses compounds of the formula: ##STR1## wherein R and R.sup.1 are selected from alkyl and phenyl and can form a cyclic group having 5 or 6 carbon atoms.The disclosed compounds are useful as herbicides.Type: GrantFiled: February 28, 1983Date of Patent: January 1, 1985Assignee: Velsicol Chemical CorporationInventor: Leonard J. Stach
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Patent number: 4489207Abstract: 2-(Hydroxyphenoxy)-carboxylates are prepared by a process wherein a dihydroxybenzene (A) is reacted with a 2-halo-fatty acid ester (B) of an alcohol, phenol or oxime of no more than 10 carbon atoms, in a molar ratio of A:B.gtoreq.1.5, in the presence of calcium hydroxide in dimethylsulfoxide, at from 0.degree. to 100.degree. C.Type: GrantFiled: December 16, 1982Date of Patent: December 18, 1984Assignee: BASF AktiengesellschaftInventors: Rainer Becker, Heinz-Gunter Oeser, Rolf-Dieter Acker
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Patent number: 4486601Abstract: Esters of 2-adamantanone oxime are prepared and are disclosed as possessing anti-inflammatory activity and antiviral activity against murine hepatitis virus.Type: GrantFiled: August 19, 1983Date of Patent: December 4, 1984Assignee: Pennwalt CorporationInventors: C. Richard Kinsolving, Vassil St. Georgiev
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Patent number: 4469889Abstract: Novel 4-phenyl-1,3-benzodiazepines, novel intermediates thereof, and methods of preparing same are described. These benzodiazepines are useful as antidepressants, analgetics and anticonvulsants.Type: GrantFiled: October 12, 1983Date of Patent: September 4, 1984Assignee: Hoechst-Roussel Pharmaceuticals, IncorporatedInventors: Lawrence L. Martin, Manfred Worm, Charles A. Crichlow
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Patent number: 4460587Abstract: 5-Diazacycloalkylimidazo[1,2-c][1,3]benzodiazepines, for example compounds of the formula ##STR1## in which e.g., R.sub.1, R.sub.2 and R.sub.4 are hydrogen, R.sub.3 is methyl and C.sub.n H.sub.2n is CH.sub.2 CH.sub.2, have neuroleptic and/or antihistaminic activity. The synthesis, pharmaceutical compositions and methods of treatment utilizing such compounds are described.Type: GrantFiled: November 29, 1982Date of Patent: July 17, 1984Assignee: Ciba-Geigy CorporationInventor: Isidoros Vlattas
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Patent number: 4386954Abstract: This invention is directed to diphenyl ethers having in the 3' position a radical of the formula: ##STR1## The products are prepared by reacting a 3'-halocarbonyl compound with an appropriately substituted oxime. These compounds and their agronomically acceptable salts and compositions containing these compounds as active ingredients are selective herbicides.Type: GrantFiled: August 17, 1981Date of Patent: June 7, 1983Assignee: Rohm and Haas CompanyInventors: John W. Ashmore, Ted T. Fujimoto
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Patent number: 4380661Abstract: 2-[p-(p-substituted phenoxy)phenoxy]propionyl oximes, processes for their preparation, herbicidal compositions containing these oximes and methods of use of the herbicidal compositions are disclosed.Type: GrantFiled: February 23, 1981Date of Patent: April 19, 1983Assignee: Hoffmann-La Roche Inc.Inventor: Milos Suchy
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Patent number: 4365991Abstract: Propionic acid oximes of the general formula ##STR1## wherein R.sub.1 is hydrogen, alkyl of from 1 to 6 carbon atoms or cycloalkyl of from 3 to 6 carbon atoms, R.sub.2 is hydrogen, alkyl of from 1 to 6 carbon atoms, alkenyl of from 2 to 6 carbon atoms or alkynyl of from 2 to 6 carbon atoms, or R.sub.1 and R.sub.2 together with the carbon atom to which they are attached form a cyclopentane or cyclohexane ring which can be mono-, di- or trisubstituted with alkyl of from 1 to 3 carbon atoms, R.sub.3 is hydrogen, halogen or nitro with the proviso that R.sub.1 and R.sub.2 are not simultaneously hydrogen, processes for their manufacture, herbicidal compositions containing these compounds as the active ingredient and methods of use of the herbicidal compositions are disclosed.Type: GrantFiled: March 6, 1981Date of Patent: December 28, 1982Assignee: Hoffmann-La Roche Inc.Inventor: Wijitha de Silva
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Patent number: 4344953Abstract: Substituted alkanyl-azolyl oxime-carbamates of the formula ##STR1## in which Az represents an optionally substituted azolyl radical,R.sup.1 represents hydrogen or alkyl,R.sup.2 represents hydrogen, alkyl, alkenyl, alkynyl, halogenoalkyl, halogenoalkenyl or alkoxyalkyl, or, provided R.sup.1 represents alkyl, R.sup.2 may represent the --(S).sub.m --R.sup.3 group,R.sup.3 represents alkyl, halogenoalkyl, optionally substituted phenyl, alkoxycarbonyl, the --NR.sup.4 R.sup.5 group or a radical identical to that to which the --(S).sub.n --R.sup.3 group is bonded,R.sup.4 represents alkyl,R.sup.5 represents alkyl, dialkylcarbamoyl, alkoxycarbonyl, alkenyloxycarbonyl, alkynyloxycarbonyl or optionally substituted phenylsulphonyl, orR.sup.4 and R.sup.Type: GrantFiled: August 29, 1980Date of Patent: August 17, 1982Assignee: Bayer AktiengesellschaftInventors: Jorg Stetter, Bernhard Homeyer, Ingeborg Hammann
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Patent number: 4273785Abstract: Novel 4-monoalkylamino-benzaldehydes, 4-mono-alkylamino-alkanophenones, and 4-monoalkylamino-benzophenones, and derivatives and salts thereof, are disclosed which are useful as anti-atherosclerotic agents.Type: GrantFiled: September 27, 1977Date of Patent: June 16, 1981Assignee: American Cyanamid CompanyInventor: Robert G. Shepherd