Benzene Ring Containing Patents (Class 564/265)
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Patent number: 4782088Abstract: The invention relates to compounds of antihypertensive and antithrombotic activity of the formula or its pharmaceutically acceptable salt: ##STR1## wherein R.sup.1 is hydrogen, lower alkyl, or lower alkoxyphenyl,R.sup.2 is hydrogen or lower alkyl,R.sup.4 is lower alkyl,R.sup.6 is hydrogen or lower alkyl,R.sup.7 is lower alkyl which is optionally substituted by hydroxy or lower alkanoyloxy, andR.sup.10 is hydrogen or lower alkyl which is optionally substituted by carboxy or esterified carboxy.Type: GrantFiled: December 29, 1986Date of Patent: November 1, 1988Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Masanori Okamoto, Morita Iwami, Shigehiro Takase, Itsuo Uchida, Kazuyoshi Umehara, Masanobu Kohsaka, Hiroshi Imanaka
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Patent number: 4709095Abstract: Ortho-aminomethylphenol compounds of the formula: ##STR1## wherein X is hydrogen or halogen, R is hydrogen or alkyl having 1 to 4 carbon atoms and A is alkyl having 1 to 4 carbon atoms, phenyl, benzyl or a bivalent radical selected from --(CH.sub.2).sub.3 -- and --O(CH.sub.2).sub.2 -- and joined together with the 3 or 5 position of the benzene nucleus to form a bicycle, or pharmaceutically acceptable salts thereof, a method of preparing said compounds and a pharmaceutical composition containing said compounds, are disclosed.Such compounds exhibit antiinflammatory, analgesic, diuretic and antihypertensive activities, so they are useful in the treatment for diseases caused by inflammation, edema or hypertension.Type: GrantFiled: March 25, 1986Date of Patent: November 24, 1987Assignee: Yoshitomi Pharmaceutical Industries, Ltd.Inventors: Tsutomu Yamanaka, Osamu Yaoka
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Patent number: 4705896Abstract: Novel ortho alkoxy substituted phenyl oxime compounds which are useful for selectively separating and recovering palladium from aqueous compositions and mixtures containing palladium and other metals.Type: GrantFiled: June 25, 1984Date of Patent: November 10, 1987Assignee: Allied CorporationInventors: Michael Van Der Puy, David S. Soriano, Jeffrey H. Dimmit
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Patent number: 4697038Abstract: Compounds of the formula ##STR1## in which; X represents a straight chain hydrocarbyl group containing from 8 to 17 carbon atoms;Y represents H or the group--CH.dbd.NOH, andZ represents H or the group--CH.dbd.NOH or the group--CPh.dbd.NOH,provided that at least one of Y and Z represents H; or such compound containing at least one electronegative substituent in the aromatic ring, may be prepared from anacardic acid and its analogues, and are useful for the extraction of copper from acidic aqueous solution. Cardanol, which has the formula ##STR2## where n=0, 2, 4 or 6 is recovered from cashew nut shell liquid containing cardol and other dihydric phenols by reacting the dihydric phenols in the CNSL with an aldehyde while leaving the cardanol substantially unreacted, and vacuum distilling the cardanol from the reaction mixture.Type: GrantFiled: March 7, 1984Date of Patent: September 29, 1987Assignee: 501 Brunel UniversityInventor: John H. P. Tyman
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Patent number: 4564698Abstract: The present invention relates to new tricyclic compounds of the formula: ##STR1## having valuable CNS and cardiovascular properties.Type: GrantFiled: January 24, 1983Date of Patent: January 14, 1986Assignee: Akzo N.V.Inventors: Johannes H. Wieringa, Frans A. van der Vlugt
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Patent number: 4551171Abstract: There is provided a new class of derivatives of 2-nitro-5-(substituted-phenoxy) phenylalkanone oximes and imines that have pre- and post-emergence herbicidal activity.Type: GrantFiled: February 1, 1980Date of Patent: November 5, 1985Assignee: Rhone-Poulenc, Inc.Inventor: Robert J. Theissen
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Patent number: 4515616Abstract: Triazolyl ketone-oximes and triazolyl dioximes of the general formula I ##STR1## where Ar is an aryl radical from the group comprising biphenylyl, naphthyl and phenyl, which radical can be substituted by halogen, nitro, cyano or trifluoromethyl, by alkyl, alkoxy or alkenyl, each of not more than 5 carbon atoms or by phenoxy, andn is 1 or 2,X is oxygen or .dbd.N--OR.sup.3, R.sup.3 being hydrogen, unsubstituted, halogen-substituted or alkoxy-substituted alkyl, alkenyl or alkynyl, each of not more than 5 carbon atoms, or benzyl which is unsubstituted or substitutedby halogen, nitro, cyano or trifluoromethyl, or by alkyl or alkoxy, each of not more than 4 carbon atoms, or is --CO--R.sup.4,R.sup.4 being unsubstituted, halogen-substituted or alkoxy-substituted alkyl of not more than 5 carbon atoms, an aromatic radical or --NH--R.sup.5, R.sup.5 being alkyl or not more than 4 carbon atoms or an aromatic radical,R.sup.Type: GrantFiled: May 27, 1983Date of Patent: May 7, 1985Assignee: BASF AktiengesellschaftInventors: Costin Rentzea, Wolfgang Spiegler, Johann Jung
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Patent number: 4504680Abstract: Novel 4-phenyl-1,3-benzodiazepines, novel intermediates thereof, and methods of preparing same are described. These benzodiazepines are useful as antidepressants, analgetics and anticonvulsants.Type: GrantFiled: October 12, 1983Date of Patent: March 12, 1985Assignee: Hoechst-Roussel Pharmaceuticals Inc.Inventors: Lawrence L. Martin, Manfred Worm, Charles A. Crichlow
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Patent number: 4465678Abstract: Aminopropiophenone derivatives of the formula ##STR1## in which X is a keto group or an oxime radical of the formula>C.dbd.N--O--R.sup.4,Y each independently is an alkyl radical, a halogen atom, or a halogenoalkyl, alkoxy, alkythio, halogenoalkoxy, halogenoalkylthio, cycloalkyl or cyano radical,n is 0, 1, 2, or 3,R.sup.1 and R.sup.2 each independently is an alkyl radical, or,R.sup.1 and R.sup.2, together with the nitrogen atom to which they are bonded, complete an optionally substituted heterocyclic radical of the formula ##STR2## or in addition, if X is >C.dbd.N--O--R.sup.4, also may complete an optionally substituted heterocyclic radical of the formula ##STR3## R.sup.3 is a hydrogen atom or an alkyl radical, and R.sup.4 is a hydrogen atom or an alkyl, alkenyl, alkinyl or aralkyl radical,or physiologically acceptable acid addition salts thereof, which possess fungicidal activity.Type: GrantFiled: November 24, 1982Date of Patent: August 14, 1984Assignee: Bayer AktiengesellschaftInventors: Hans-Joachim Knops, Wolfgang Kramer, Paul-Ernst Frohberger
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Patent number: 4464300Abstract: There are presented benzazepines of the formula ##STR1## wherein either R.sup.1 is hydrogen, lower alkyl, 4-pyridyl or the group --(CH.sub.2).sub.n --NR.sup.6 R.sup.7 and R.sup.2 and R.sup.3 together are an additional bond or R.sup.1 and R.sup.2 together are the oxo group and R.sup.3 is hydrogen or lower alkyl, R.sup.4 is phenyl, o-halophenyl or 2-pyridyl, R.sup.5 is halogen or nitro and either R.sup.6 is hydrogen or lower alkyl and R.sup.7 is hydrogen, lower alkyl, lower alkenyl or lower alkynyl or R.sup.6 and R.sup.7 together with the nitrogen atom are 4-(lower alkyl)-1-piperazinyl or 4-morpholinyl and n is the number 0 or 1, and their pharmaceutically acceptable acid additions salts.The compounds possess interesting psychotropic properties, i.e., pronounced anxiolytic properties have been established in the case of certain representative members of this class of substance.Type: GrantFiled: July 15, 1982Date of Patent: August 7, 1984Assignee: Hoffmann-La Roche Inc.Inventors: Rene Borer, Max Gerecke, Emilio Kyburz
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Patent number: 4408077Abstract: A process and intermediates for preparing 6-(lower alkoxy)-5-(trifluoromethyl)-1-naphthalenecarboxylic acid derivatives are disclosed. The derivatives are useful for preparing aldose reductase inhibitors. With reference to the process, 1,1,1-trifluoro-5-(2-methylphenyl)-2,3-pentadione 3-oxime is cyclized to give a key intermediate 3,4-dihydro-1-hydroxy-5-methyl-1-(trifluoromethyl)-2(1H)-naphthalenone oxime; and 3,4-dihydro-1-hydroxy-5-methyl-1-(trifluoromethyl)-2(1H)-naphthalenone is aromatized to 5-methyl-1-(trifluoromethyl)-2-naphthalenol with a dehydrating agent.Type: GrantFiled: November 13, 1981Date of Patent: October 4, 1983Assignee: Ayerst, McKeena & Harrison, Inc.Inventors: Kazimir Sestanj, Steven Fung, Nedumparambil A. Abraham, Francesco Bellini
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Patent number: 4401602Abstract: Compounds, such as 5-(2-chloro-4-trifluoromethylphenoxy)-2-nitroacetophenone oxime-O-(acetic acid, methyl ester) and 5-(2-chloro-4-trifluoromethylphenoxy)-2-chloroacetophenone oxime-O-(acetic acid, methyl ester), are useful for postemergence and preemergence control of weeds, and are represented by Formula I of the application.Type: GrantFiled: April 30, 1982Date of Patent: August 30, 1983Assignee: PPG Industries, Inc.Inventor: Dennis K. Krass
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Patent number: 4344789Abstract: Compounds, such as 5-(2-chloro-4-trifluoromethylphenoxy)-2-nitroacetophenone oxime-O-(acetic acid, methyl ester) and 5-(2-chloro-4-trifluoromethylphenoxy)-2-chloroacetophenone oxime-O-(acetic acid, methyl ester), are useful for postemergence and preemergence control of weeds, and are represented by Formula I of the application.Type: GrantFiled: April 15, 1980Date of Patent: August 17, 1982Assignee: PPG Industries, Inc.Inventor: Dennis K. Krass
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Patent number: 4337358Abstract: Primary saturated aliphatic and alicyclic amines are oxidized by elemented oxygen to oximes, especially cyclohexylamine to cyclohexanone oxime, in vapor phase using silica gel catalyst; preferably using concentrations by volume such as 1% to 5% of amine and 5% to 30% of oxygen, and using temperatures between about 120.degree. C. and 250.degree. C. at atmospheric pressure.Type: GrantFiled: April 13, 1981Date of Patent: June 29, 1982Assignee: Allied CorporationInventor: John N. Armor
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Patent number: 4332810Abstract: Novel N-(substituted) derivatives of 2,5-ethano-8-hydroxy (or methoxy)-1,2,3,4,5,6-hexahydro-3 (or 4)-benzazocine of the formula: ##STR1## are centrally acting analgesics effective in the relief of pain.Type: GrantFiled: January 26, 1981Date of Patent: June 1, 1982Assignee: Merck & Co., Inc.Inventors: Patrice C. Belanger, Robert N. Young
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Patent number: 4313959Abstract: (Arylmethyl)phenyl-aminocyclohexanols, (arylmethyl)phenyl aminocyclohexenes and (arylmethyl)phenyl-aminocyclohexanes and methods of preparing same are described. These compounds are useful as antidepressants and anticonvulsants.Compounds 8-[2-(phenylmethyl)phenyl]-1,4-dioxaspiro[4,5]-decan-8-ol, 1-[2-(phenylmethyl)phenyl]-4-oxocyclohexanol, and 1-[2-(phenylmethyl)phenyl]-4-oxocyclohexanol oxime, and methods of preparing same are also described. These compounds are useful as intermediates for preparing the antidepressant and anticonvulsant compounds.Type: GrantFiled: April 27, 1981Date of Patent: February 2, 1982Assignee: Hoechst-Roussel Pharmaceuticals Inc.Inventors: Lawrence L. Martin, Manfred Worm
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Patent number: 4309424Abstract: Novel 4-phenyl-1,3-benzodiazepines, novel intermediates thereof, and methods of preparing same are described. These benzodiazepines are useful as antidepressants, analgetics and anticonvulsants.Type: GrantFiled: November 5, 1979Date of Patent: January 5, 1982Assignee: Hoechst-Roussel Pharmaceuticals IncorporatedInventors: Lawrence L. Martin, Manfred Worm, Charles A. Crichlow
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Patent number: 4304938Abstract: 3-Phenoxybenzene derivatives are prepared by a method which comprises the steps of(a) chlorinating benzaldehyde with chlorine gas in the presence of a hydrocarbon and a Lewis acid catalyst to obtain 3-chlorobenzaldehyde; (b) reacting the 3-chlorobenzaldehyde with ethylene glycol to obtain 2-(3-chlorophenyl)-1,3-dioxolane; (c) etherifying said dioxolane with an alkali phenolate to yield the intermediate 2-(3-phenoxyphenyl)-1,3-dioxolane and converting this intermediate to the corresponding aldehyde, cyanohydrin, sulfonic acid salt or oxime derivative.Type: GrantFiled: December 21, 1979Date of Patent: December 8, 1981Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara RTInventors: Endre Palosi, Gergely Heja, Dezso Korbonits, Pal Kiss, Csaba Gonczi, Judit Cser nee Kun, Ida Szvoboda nee Kauzel, Gabor Kovacs, Gabor Szabo, Tamas Kallay, Laszlo Ledniczky
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Patent number: 4277621Abstract: Novel substituted 11-amino-undeca-4,8-dienal and 11-amino-undecanal aldehyde-derivatives of the formulae Ia ##STR1## in which R.sub.1 to R.sub.6, Y and m are as defined in patent claim 1, and processes for their preparation are described. The compounds of the formulae Ia and Ib can be catalytically hydrogenated to novel 1,11-diaminoundecanes, which, in turn, can be used, for example, for the preparation of polycondensation products, in particular transparent polyamides, or as curing agents for epoxide resins.Type: GrantFiled: October 9, 1979Date of Patent: July 7, 1981Assignee: Ciba-Geigy CorporationInventors: Dieter Reinehr, Josef Pfeifer
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Patent number: 4248837Abstract: Dioxime extractants having the following general formula: ##STR1## where R and R' may be any of a variety of organic hydrocarbon radicals such as aliphatic, alkyl and aryl radicals. R and R' may also be hydrogen. Preferably R is an unsaturated hydrocarbon or branch chain alkyl group containing from about 3 to 20 carbon atoms and R' is hydrogen or an unsaturated hydrocarbon or branch chain alkyl group containing from about 1 to 10 carbon atoms. Preferably, there is a difference of about 3 to 10 carbon atoms between R and R' resulting in dissymmetry of the resulting dioxime molecule. Preferably, the dioximes also contain a total of about 5 to 32 carbon atoms. Representative compounds are methyl octyl dioxime and methyl hexyl dioxime.Organic preparations containing such dioximes are useful for the extraction of copper, nickel and cobalt metal values from acid or basic aqueous solution.Type: GrantFiled: February 9, 1979Date of Patent: February 3, 1981Assignee: Kennecott Copper CorporationInventors: Ralph W. M. Lai, John K. Litchfield
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Patent number: 4248795Abstract: An improved process for preparing an organic sulfone compound by oxidizing the corresponding sulfide compound with an aqueous peracid solution.Type: GrantFiled: February 10, 1977Date of Patent: February 3, 1981Assignee: Union Carbide CorporationInventor: John K. Chan
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Patent number: 4242277Abstract: In the process of subjecting a compound selected from phenols, N,N-dialkylanilines and mixtures thereof to nitrosation reaction conditions using a nitrite in an aqueous system to prepare nitrosated products selected from benzoquinone oximes and p-nitroso-N,N-dialkylanilines, the nitrosation reaction is advantageously carried out in the presence of an acid stronger than nitrous acid an organic acid of pKa 2 to pKa 5 or a salt thereof and water, the quantities of the organic acid and water being up to 5 times by mole and up to 10 times by weight the quantity of the compound to be nitrosated, respectively.Type: GrantFiled: May 30, 1979Date of Patent: December 30, 1980Assignee: Mitsubishi Petrochemical Company, LimitedInventors: Morihisa Tanaka, Kazuhiko Konno, Norio Sasaki, Kunio Uchimura
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Patent number: 4234580Abstract: Carbamate thiosulfenylcarbamoyl fluoride compounds are insecticidal and miticidal compounds and are also useful intermediates in the preparation of pesticidally active bis-carbamate disulfide compounds.Type: GrantFiled: March 28, 1977Date of Patent: November 18, 1980Assignee: Union Carbide CorporationInventor: Themistocles D. J. D'Silva
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Patent number: 4234546Abstract: A process is described for the selective recovery of nickel values from an aqueous solution containing nickel values by means of liquid/liquid extraction, wherein the aqueous solution is contacted with an organic extractant comprising a substantially water-immisicible organic solvent and one or more of certain alpha,beta-dioxime compounds. Novel alpha, beta-dioxime compounds for use in the extraction process are also described.Type: GrantFiled: March 1, 1979Date of Patent: November 18, 1980Assignee: Shell Oil CompanyInventors: Abraham J. van der Zeeuw, Peter Koenders, Riekert Kok