Benzene Ring Containing Patents (Class 564/26)
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Patent number: 8410150Abstract: A CPT inhibitor compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof: or a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. A method of treating a subject having cancer comprises administering to the subject a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof.Type: GrantFiled: March 6, 2008Date of Patent: April 2, 2013Assignee: University Health NetworkInventors: Heinz W. Pauls, Peter Brent Sampson, Bryan T. Forrest, Radoslaw Laufer, Yong Liu, Miklos Feher, Yi Yao, Guohua Pan
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Patent number: 8383652Abstract: Novel biaromatic compounds that modulate peroxisome proliferator-activator receptors, known as PPAR, having the formula (I): are formulated into pharmaceutical compositions useful in human or veterinary medicine, or alternatively, in cosmetic compositions.Type: GrantFiled: April 28, 2008Date of Patent: February 26, 2013Assignee: Galderma Research & DevelopmentInventors: Jean-Guy Boiteau, Laurence Clary, Laurent Chantalat, Michel Rivier
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Patent number: 8334405Abstract: Chiral thioureas are effective catalysts for the borane reduction of prochiral ketones to optically active alcohols. A prochiral ketone may be reduced to an optically active alcohol in the presence of a substantially sub-stoichiometric amount of chiral thiourea. The asymmetric thiourea compound of the present invention may be produced according to a production method described herein.Type: GrantFiled: April 3, 2008Date of Patent: December 18, 2012Assignee: Board of Regents, The University of Texas SystemInventors: Derun Li, John R. Falck
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Patent number: 8288014Abstract: A novel fluorene-containing compound and an organic electroluminescent device including an organic layer employing the same. The fluorene-containing compound has excellent electrical characteristics and an excellent charge transporting capability, and so can be used as a hole injecting material, hole transporting material, and/or emitting material that is suitable for all-color fluorescent and phosphorescent devices, such as red, green, blue, and white fluorescent and phosphorescent devices. Accordingly, an organic electroluminescent device employing the fluorene-containing compound has high efficiency, a low driving voltage, high brightness, and a long lifetime.Type: GrantFiled: August 25, 2009Date of Patent: October 16, 2012Assignee: Samsung Mobile Display Co., Ltd.Inventors: Seok-Hwan Hwang, Young-Kook Kim, Yoon-Hyun Kwak, Jeoung-In Yi, Chang-Ho Lee
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Patent number: 8247452Abstract: The invention relates to urea- and urethane-substituted acylureas and to their physiologically tolerated salts and physiologically functional derivatives. In particular, the invention relates to the compounds of the formula I wherein the radicals have meanings described herein, and to their physiologically tolerated salts and to processes for their preparation. The compounds are suitable for example as antidiabetics.Type: GrantFiled: August 27, 2007Date of Patent: August 21, 2012Assignee: Sanofi-Aventis Deutschland GmbHInventors: Elisabeth DeFossa, Dieter Kadereit, Thomas Klabunde, Hans-Joerg Burger, Andreas Herling, Karl-Ulrich Wendt, Erich Von Roedern, Karl Schoenafinger
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Patent number: 8148575Abstract: The present invention provides a process for [18F]-fluorination of biomolecules containing a primary amino group such as proteins and peptides and in particular of peptides. The invention further provides reagents for this process, in particular 18F-labelled prosthetic groups for use in the preparation as well as non-labelled intermediates useful in the preparation of the [18F]-labelled prosthetic groups. [18F]-labelled compounds useful as radiopharmaceuticals, specifically for use in Positron Emission Tomography (PET) are also provided.Type: GrantFiled: April 20, 2007Date of Patent: April 3, 2012Assignee: Hammersmith Imanet LimitedInventors: Erik Arstad, Matthias Eberhard Glaser
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Patent number: 7863332Abstract: Novel biaromatic compounds having the general formula (I): and cosmetic/pharmaceutical compositions comprised thereof are useful in human or veterinary medicine (in dermatology and also in the fields of cardiovascular diseases, of immune diseases and/or of diseases related to the metabolism of lipids) or, alternatively, in cosmetic compositions.Type: GrantFiled: February 16, 2007Date of Patent: January 4, 2011Assignee: Galderma Research & DevelopmentInventors: Laurence Clary, Jean-Guy Boiteau, Corinne Millois Barbuis
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Patent number: 7812185Abstract: A cross-metathesis process for preparing an ?,?-functionalized olefin, such as methyl 9-decenoate, and an ?-olefin having three or more carbon atoms, such as 1-decene.Type: GrantFiled: June 2, 2006Date of Patent: October 12, 2010Assignee: Dow Global Technologies Inc.Inventors: Kenneth A. Burdett, Morteza Mokhtarzadeh, Francis J. Timmers
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Patent number: 7678812Abstract: This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to ?-aminotetralin-derived ureas that are potent antagonists or agonists of VR1 which are useful for the treatment and prevention of inflammatory and other pain conditions in mammals.Type: GrantFiled: October 23, 2007Date of Patent: March 16, 2010Assignee: Janssen Pharmaceutica NVInventors: Ellen Codd, Scott L. Dax, Michele Jetter, Mark McDonnell, James J. McNally, Mark Youngman
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Patent number: 7632970Abstract: The present invention relates to a production method of asymmetric compound (IV) which includes conjugately adding nucleophilic reagent (III) to compound (II) in the presence of asymmetric urea compound (I). The present invention provides a non-metallic asymmetric catalyst capable of realizing a highly stereoselective asymmetric conjugate addition reaction in a high yield, and an advantageous production method of an asymmetric compound by an asymmetric conjugate addition reaction using the asymmetric catalyst.Type: GrantFiled: June 25, 2004Date of Patent: December 15, 2009Assignee: Sumitomo Chemical Company, LimitedInventor: Yoshiji Takemoto
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Patent number: 7572934Abstract: The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.Type: GrantFiled: April 10, 2008Date of Patent: August 11, 2009Assignee: Amgen Inc.Inventors: Sean P. Brown, Paul Dransfield, Zice Fu, Jonathan Houze, Xian Yun Jiao, Todd J. Kohn, Vatee Pattaropong, Marc Vimolratana, Michael J. Schmitt
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Patent number: 7560591Abstract: Compounds which can be represented by the general formula (I) indicated below: and in which: A is selected independently from the carboxamide group, the thiocarboxamide group, and the carbonyl group, R1 is selected from an alkyl group having from 1 to 3 carbon atoms and the amino group, unsubstituted or substituted with the nitro group or the methyl group, R2 is selected independently from hydrogen, an alkyl group having from 1 to 4 carbon atoms, the methoxy, ethoxy, propoxy group, a mono-, bi- or tricyclic cycloalkane residue having from 5 to 12 carbon atoms, the adamantyl group, an aryl, naphthyl or heterocyclic group, unsubstituted or substituted with methyl, methoxy, hydroxy, amino or halogen groups, R3 and R4 are selected independently from hydrogen and an alkyl group having from 1 to 3 carbon atoms, R5 represents one or two substituents independently selected from hydrogen and the methyl, methoxyl and hydroxyl groups, n is a whole number from 0 to 6, and the amidine group is in the para or meta pType: GrantFiled: April 30, 2008Date of Patent: July 14, 2009Assignee: Rotta Research Laboratorium S.p.A.Inventors: Francesco Makovec, Simona Zanzola, Roberto Artusi, Lucio Claudio Rovati
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Publication number: 20090075819Abstract: The present invention relates to Indanyl- and Tetrahydronaphtyl-amino-thiourea compounds of formula I wherein the variables R1 to R4 are as in the description. The invention relates also to methods of combating or controlling insects, arachnids or nematodes, to methods for protecting growing plants from attack or infestation by insects, arachnids or nematodes, to methods for the protection of seeds from soil insects and of the seedlings' roots and shoots from soil and foliar insects and to methods for treating, controlling, preventing or protecting animals against infestation or infection.Type: ApplicationFiled: November 15, 2006Publication date: March 19, 2009Applicant: BASF SEInventors: Markus Kordes, Christopher Koradin, Deborah L. Culbertson
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Publication number: 20080207621Abstract: Disclosed are sulfonamide compounds and compositions that inhibit soluble epoxide hydrolase (sEH), methods for preparing the compounds and compositions, and methods for treating patients with such compounds and compositions. The compounds, compositions, and methods are useful for treating a variety of sEH mediated diseases, including hypertensive, cardiovascular, inflammatory, pulmonary, and diabetes-related diseases.Type: ApplicationFiled: September 28, 2007Publication date: August 28, 2008Inventor: Richard D. Gless
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Publication number: 20080125424Abstract: The present invention relates generally to compounds represented in Formula I, pharmaceutical compositions comprising them and methods of treating of diseases or disorders related to the function of the calcium sensing receptor. The invention also relates to processes for making such compounds and to intermediates useful in these processes.Type: ApplicationFiled: July 10, 2007Publication date: May 29, 2008Inventors: Pierre DePrez, Sarah E. Lively, Taoues Temal
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Patent number: 7326746Abstract: Electron donor compounds, suitable for use as adhesives or as components in adhesives, contain a carbon to carbon double bond attached to an aromatic ring and conjugated with the unsaturation in the aromatic ring.Type: GrantFiled: February 17, 2005Date of Patent: February 5, 2008Inventors: Osama M. Musa, Donald E. Herr, Nikola A. Nikolic
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Patent number: 7323496Abstract: Novel acyl urea, thiourea, carbamate, thiocarbamate and related compounds are provided which are effective in inhibiting the cytokine-mediated inflammatory response in cultured cells, in ameliorating bone destruction in an animal model of arthritis and in lowering blood glucose levels in animal models of Type II diabetes mellitus. The compounds are disclosed as useful for a variety of treatments including the treatment of diabetes mellitus, insulin resistance, inflammation, inflammatory diseases, immunological diseases and cancer.Type: GrantFiled: May 7, 2003Date of Patent: January 29, 2008Assignee: Theracos, Inc.Inventors: Partha Neogi, Debedranath Dey, Joseph Fuller, Liang Chen, Ta-Kai Li
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Patent number: 7265136Abstract: A compound for use in inducing necrosis in vascular tissue of a tumor in an animal. The compound contains a first moiety which is a cis-stilbene moiety and a second moiety which is an inhibitor of the formation or action of nitric acid. Also, a method for inducing necrosis in vasculature of a tumor in an animal by administering to the animal the compound in an amount effective for inducing the necrosis.Type: GrantFiled: February 15, 2000Date of Patent: September 4, 2007Assignee: Angiogene Pharmaceuticals Ltd.Inventor: Peter David Davis
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Patent number: 7262220Abstract: The invention relates to urea- and urethane-substituted acylureas and to their physiologically tolerated salts and physiologically functional derivatives. In particular, the invention relates to the compounds of the formula I wherein the radicals have meanings described herein, and to their physiologically tolerated salts and to processes for their preparation. The compounds are suitable for example as antidiabetics.Type: GrantFiled: July 11, 2003Date of Patent: August 28, 2007Assignee: Sanofi-Aventis Deutschland GmbHInventors: Elisabeth Defossa, Dieter Kadereit, Thomas Klabunde, Hans-Joerg Burger, Andreas Herling, Karl-Ulrich Wendt, Erich Von Roedern, Karl Schoenafinger
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Patent number: 7132295Abstract: This application relates to isotopically labeled affinity markers of the formula (II) for mass spectrometric analysis of proteins. In formula (II), the groups A, PRG, S, Z, L', Z', R, R', k, l, m, and n are as defined in the claims. The application also provides a process for preparing these materials, a method for analyzing proteins using such materials, and a kit containing one or more of these materials.Type: GrantFiled: October 30, 2002Date of Patent: November 7, 2006Assignee: Bayer AktiengesellschaftInventors: Hans-Georg Lerchen, Hans-Ulrich Siegmund, Dorian Immler, Andreas Schumacher, Daniel Auriel
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Patent number: 7109375Abstract: An additive for an alkaline zinc or zinc alloy electroplating bath medium, the additive comprising a random co-polymer comprising the reaction product of: (i) one or more di-tertiary amines including an amide or thioamide functional group, and (ii) optionally, one or more saturated second di-tertiary amines and/or one or more second di-tertiary amines including an unsaturated moiety, with (iii) one or more saturated or unsaturated linking agents capable of reacting with said di-tertiary amines (i) and (ii), provided that, where all the linking agents are saturated, an unsaturated di-tertiary amine must he present. Preferably, the polymer has the general formula n(2x+2y+zEp)j-.Type: GrantFiled: July 11, 2001Date of Patent: September 19, 2006Inventors: Roderick Dennis Herdman, Trevor Pearson, Anthony Rowan
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Patent number: 7094807Abstract: The invention provides compounds and pharmaceutically acceptable salts of Formula I wherein the variables A1, A2, R1, R2, V, W, X, Y, and Z are defined herein. Certain compounds of Formula I described herein which possess potent antiviral activity. The invention particularly provides compounds of Formula I that are potent and/or selective inhibitors of Hepatitis C virus replication. The invention also provides pharmaceutical compositions containing one or more compound of Formula I, or a salt, solvate, or acylated prodrug of such compounds, and one or more pharmaceutically acceptable carriers, excipients, or diluents. The invention further comprises methods of treating patients suffering from certain infectious diseases by administering to such patients an amount of a compound of Formula I effective to reduce signs or symptoms of the disease or disorder. These infectious diseases include viral infections, particularly HCV infections.Type: GrantFiled: November 18, 2003Date of Patent: August 22, 2006Assignee: Achillion Pharmaceuticals, Inc.Inventors: Dawei Chen, Milind Deshpande, Andrew Thurkauf, Avinash Phadke, Xiangzhu Wang, Yiping Shen, Cuixian Liu, Jesse Quinn, Junko Ohkanda, Shouming Li
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Patent number: 7053243Abstract: 1-(3-methoxybenzyl)-3-substituted thiourea antioxidant compounds and improved lipids compositions which are supplemented with amounts of such antioxidant compounds effective for augmenting oxidative stability of the base lipid are provided. Also provided are methods for enhancing the oxidative stability of a lipid comprising supplementing a base lipid in need of enhanced oxidative stability with at least one 1-(3-methoxybenzyl)-3-substituted thiourea compound of the present invention.Type: GrantFiled: August 1, 2003Date of Patent: May 30, 2006Assignees: The Fanning Corporation, The United States of America as represented by the Secretary of AgricultureInventors: Thomas P. Abbott, Alan Wohlman
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Patent number: 6995285Abstract: The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for treating coronary artery disease.Type: GrantFiled: June 4, 2002Date of Patent: February 7, 2006Assignee: CV Therapeutics, Inc.Inventors: Prabha N. Ibrahim, Robert Jiang, Christopher Morrison, Kevin Shenk, Jeff A. Zablocki
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Patent number: 6984647Abstract: This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to ?-aminotetralin-derived ureas that are potent antagonists or agonists of VR1 which are useful for the treatment and prevention of inflammatory and other pain conditions in mammals.Type: GrantFiled: May 15, 2003Date of Patent: January 10, 2006Assignee: Janssen Pharmaceutica N.V.Inventors: Scott L. Dax, Michele Jetter, Mark McDonnell, James J. McNally, Mark Youngman
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Patent number: 6908957Abstract: Electron donor compounds, suitable for use as adhesives or as components in adhesives, contain a carbon to carbon double bond attached to an aromatic ring and conjugated with the unsaturation in the aromatic ring.Type: GrantFiled: August 3, 2001Date of Patent: June 21, 2005Assignee: National Starch and Chemical Investment Holding CorporationInventors: Osama M. Musa, Donald E. Herr, Nikola A. Nikolic
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Patent number: 6866833Abstract: A substituted thiourea having the general formula characterized in that each of R1 and R2 independently comprises an alkyl, alkaryl or aryl group or a substituted derivative thereof, and contains at least one fluorine atom, and in that each of R3 and R4 is selected from the group which consists of H, alkyl, alkaryl and aryl and substituted derivatives thereof, including fluorine-containing derivatives. A method for producing the substituted thiourea is disclosed, and a method for extracting a noble metal such as gold from a matrix by treating the matrix with the substituted thiourea is also disclosed.Type: GrantFiled: February 8, 2000Date of Patent: March 15, 2005Assignee: University College CorkInventors: Jeremy Denis Glennon, Jane Harris, Stephen John Harris
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Patent number: 6861556Abstract: Couplers for hair coloring compositions for oxidative dyeing of hair are compounds of formula (1): wherein X is selected from halogen; R3 is selected from the group consisting of C1 to C2 alkyl and hydroxyethyl; and R, R1 and R2 are each independently selected from C1 to C22 alkyl or C1 to C22 mono or dialkyl groups, or two of R, R1 and R2 together with the the nitrogen atom to which they are attached form a C3 to C6 cycloaliphatic or a C3 to C14 aromatic group, the cycloaliphatic or aromatic group optionally containing in their rings one or more hetero atoms selected from O, S and N atoms.Type: GrantFiled: May 17, 2004Date of Patent: March 1, 2005Assignee: The Procter & Gamble CompanyInventors: Mu-Ill Lim, Yuh-Guo Pan
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Patent number: 6838472Abstract: The current invention provide novel compounds, methods of treating or preventing emphysema, cancer and dermatological disorders, pharmaceutical compositions suitable for the treatment or prevention of emphysema, cancer and dermatological disorders and methods for delivering formulations into the lung of a mammal suffering from emphysema, cancer and dermatological disorders.Type: GrantFiled: September 17, 2002Date of Patent: January 4, 2005Assignee: Syntex (U.S.A.) LLCInventors: Michael Klaus, Jean-Marc Lapierre
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Patent number: 6794541Abstract: This invention provides combinatorial chemistry libraries containing thiourea and urea compounds. In addition, the invention relates to methods for constructing combinatorial chemistry libraries containing thiourea and urea compounds. Furthermore, this invention relates to methods for the identification of bioactive thiourea and urea compounds as well as compositions and therapeutic methods for treating cancer.Type: GrantFiled: September 19, 2001Date of Patent: September 21, 2004Assignee: Parker Hughes InstituteInventors: Zhaohai Zhu, Chen Mao, Rama K. Narla, Fatih M. Uckun
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Patent number: 6776802Abstract: Couplers for hair coloring compositions for oxidative dyeing of hair are compounds of formula (1): wherein X is selected from halogen; R3 is selected from the group consisting of C1 to C2 alkyl and hydroxyethyl; and R, R1 and R2 are each independently selected from C1 to C22 alkyl or C1 to C22 mono or dialkyl groups, or two of R, R1 and R2 together with the the nitrogen atom to which they are attached form a C3 to C6 cycloaliphatic or a C3 to C14 aromatic group, the cycloaliphatic or aromatic group optionally containing in their rings one or more hetero atoms selected from O, S and N atoms.Type: GrantFiled: November 16, 2001Date of Patent: August 17, 2004Assignee: The Procter & Gamble CompanyInventors: Mu-Ill Lim, Yuh-Guo Pan
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Patent number: 6774233Abstract: Disclosed are novel processes and novel intermediate compounds for preparing aryl- and heteroaryl-substituted urea compounds of the formula(I) wherein Ar1, Ar2, L, Q and X are described herein. The product compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases.Type: GrantFiled: February 10, 2003Date of Patent: August 10, 2004Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.Inventors: Lin-Hua Zhang, Lei Zhu
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Publication number: 20040142982Abstract: Novel antagonists of ∝4&bgr;1 integrin and/or ∝4&bgr;7 integrin of the general Formula I: wherein R1, R2, R5, L1, L2, Rb, W and Z are as defined in any one of claims 1 to 13, A represents —CH— or a nitrogen atom, and p is from 0 to 4.Type: ApplicationFiled: February 23, 2004Publication date: July 22, 2004Inventors: Juan Miguel Jimenez Mayorga, Jordi Bach Tana, Jesus Maria Ontoria Ontoria, Eloisa Navarro Romero
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Publication number: 20040097593Abstract: Novel acyl urea, thiourea, carbamate, thiocarbamate and related compounds are provided which are effective in inhibiting the cytokine-mediated inflammatory response in cultured cells, in ameliorating bone destruction in an animal model of arthritis and in lowering blood glucose levels in animal models of Type II diabetes mellitus. The compounds are disclosed as useful for a variety of treatments including the treatment of diabetes mellitus, insulin resistance, inflammation, inflammatory diseases, immunological diseases and cancer.Type: ApplicationFiled: May 7, 2003Publication date: May 20, 2004Inventors: Partha Neogi, Debedranath Dey, Joseph C. Fuller, Liang Chen, Ta-Kai Li
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Patent number: 6713650Abstract: The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for treating coronary artery disease.Type: GrantFiled: December 5, 2001Date of Patent: March 30, 2004Inventors: Prabha N. Ibrahim, Robert Jiang, Christopher Morrison, Kevin Shenk, Jeff A. Zablocki, Richard Lawn
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Publication number: 20040030188Abstract: 1-(3-methoxybenzyl)-3-substituted thiourea antioxidant compounds and improved lipids compositions which are supplemented with amounts of such antioxidant compounds effective for augmenting oxidative stability of the base lipid are provided. Also provided are methods for enhancing the oxidative stability of a lipid comprising supplementing a base lipid in need of enhanced oxidative stability with at least one 1-(3-methoxybenzyl)-3-substituted thiourea compound of the present invention.Type: ApplicationFiled: August 1, 2003Publication date: February 12, 2004Applicants: Secretary of Agriculture, The Fanning CorporationInventors: Thomas P. Abbott, Alan Wohlman
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Publication number: 20030236287Abstract: The invention provides compounds of Formula I: 1Type: ApplicationFiled: April 25, 2003Publication date: December 25, 2003Inventors: David W. Piotrowski, Bruce N. Rogers, William W. McWhorter, Daniel Patrick Walker, Jeffrey W. Corbett, Vincent E. Groppi, Daniel G. Rudmann
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Patent number: 6653505Abstract: 1-(3-methoxybenzyl)-3-substituted thiourea antioxidant compounds and improved lipids compositions which are supplemented with amounts of such antioxidant compounds effective for augmenting oxidative stability of the base lipid are provided. Also provided are methods for enhancing the oxidative stability of a lipid comprising supplementing a base lipid in need of enhanced oxidative stability with at least one 1-(3-methoxybenzyl)-3-substituted thiourea compound of the present invention.Type: GrantFiled: April 23, 2001Date of Patent: November 25, 2003Assignees: The United States of America as represented by the Secretary of Agriculture, The Fanning CorporationInventors: Thomas P. Abbott, Alan Wohlman
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Publication number: 20030203944Abstract: The present invention relates to an antagonist against vanilloid receptor and the pharmaceutical compositions containing the same. As diseases associated with the activity of vanilloid receptor, pain, acute pain, chronic pain, neuropathic pain, post-operative pain, migraine, arthralgia, neuropathies, nerve injury, diabetic neuropathy, neurodegeneration, neurotic skin disorder, stroke, urinary bladder hypersensitiveness, irritable bowel syndrome, a respiratory disorder such as asthma or chronic obstructive pulmonary disease, irritation of skin, eye or mucous membrane, fevescence, stomach-duodenal ulcer, inflammatory bowel disease and inflammatory diseases can be enumerated. The present invention provides a pharmaceutical composition for prevention or treatment of these diseases.Type: ApplicationFiled: February 3, 2003Publication date: October 30, 2003Inventors: Young Ger Suh, Uh Taek Oh, Hee Doo Kim, Jee Woo Lee, Hyeung Geun Park, Young Ho Park, Jung Bum Yi
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Publication number: 20030204113Abstract: 1-(3-methoxybenzyl)-3-substituted thiourea antioxidant compounds and improved lipids compositions which are supplemented with amounts of such antioxidant compounds effective for augmenting oxidative stability of the base lipid are provided. Also provided are methods for enhancing the oxidative stability of a lipid comprising supplementing a base lipid in need of enhanced oxidative stability with at least one 1-(3-methoxybenzyl)-3-substituted thiourea compound of the present invention.Type: ApplicationFiled: April 29, 2003Publication date: October 30, 2003Applicants: the United States of America, as Represented by the Secretary of Agriculture, The Fanning CorporationInventors: Thomas P. Abbott, Alan Wohlman
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Patent number: 6586628Abstract: 1-(3-methoxybenzyl)-3-substituted thiourea antioxidant compounds and improved lipids compositions which are supplemented with amounts of such antioxidant compounds effective for augmenting oxidative stability of the base lipid are provided. Also provided are methods for enhancing the oxidative stability of a lipid comprising supplementing a base lipid in need of enhanced oxidative stability with at least one 1-(3-methoxybenzyl)-3-substituted thiourea compound of the present invention.Type: GrantFiled: February 14, 2002Date of Patent: July 1, 2003Assignees: The United States of America, as represented by the Secretary of Agriculture, The Fanning CorporationInventors: Thomas P. Abbott, Alan Wohlman
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Patent number: 6583282Abstract: Disclosed are novel processes and novel intermediate compounds for preparing aryl- and heteroaryl-substituted urea compounds of the formula (I) wherein Ar1, Ar2, L, Q and X are described herein. The product compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases.Type: GrantFiled: July 6, 2000Date of Patent: June 24, 2003Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.Inventors: Lin-Hua Zhang, Lei Zhu
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Patent number: 6498253Abstract: Compounds of the formula (I) and salts thereof in which W1, W2, R, n, R1, R2, R4, X, Y and Z are as defined in claim 1 and R3 is an acyl radical, are suitable as herbicides and plant growth regulators. The herbicides can be prepared by the process variants from claim 5, the novel intermediate products (II), (IV), (VI) and (VIII)* of claims 9 and 10 being employed.Type: GrantFiled: February 25, 1999Date of Patent: December 24, 2002Assignee: Hoechst Schering AgrEvo GmbHInventors: Gerhard Schnabel, Lothar Willms, Klaus Bauer, Hermann Bieringer
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Patent number: 6468406Abstract: The invention is directed to an anion-complexing compound with the formula I wherein R1 is a six-membered ring, Y′ is —NHC(X)NH—, and Y″ is selected from the group consisting of —NHC(X′)—, —C(X′)NH—, and —NHC(X′) NH—; and wherein X and X′, independently of one another, is a sulphur or oxygen atom. R4 and R4′ are either identical represented by a variety of groups or together represent a group such that the compound has a macrocyclic structure. The invention is also directed to a method of preparing such a compound, an ion-selective membrane, as well as a sensor provided with such a compound or membrane.Type: GrantFiled: November 27, 2000Date of Patent: October 22, 2002Assignee: Priva Holding B.V.Inventors: Martijn Marcus Gabriël Antonisse, David Nicolaas Reinhoudt, Bianca Henriëtte Maria Snellink-Ruël, Peter Timmerman
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Publication number: 20020147365Abstract: 1-(3-methoxybenzyl)-3-substituted thiourea antioxidant compounds and improved lipids compositions which are supplemented with amounts of such antioxidant compounds effective for augmenting oxidative stability of the base lipid are provided. Also provided are methods for enhancing the oxidative stability of a lipid comprising supplementing a base lipid in need of enhanced oxidative stability with at least one 1-(3-methoxybenzyl)-3-substituted thiourea compound of the present invention.Type: ApplicationFiled: February 14, 2002Publication date: October 10, 2002Applicant: The Fanning CorporationInventors: Thomas P. Abbott, Alan Wohlman
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Publication number: 20020137968Abstract: Benzoic acid derivatives of the formula I 1Type: ApplicationFiled: October 10, 2001Publication date: September 26, 2002Inventors: John Lloyd, George C. Rovnyak, Philip D. Stein, Saleem Ahmad, Karnail S. Atwal, Thomas J. Caulfield, Michael A. Poss
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Publication number: 20020103380Abstract: This invention provides combinatorial chemistry libraries containing thiourea and urea compounds. In addition, the invention relates to methods for constructing combinatorial chemistry libraries containing thiourea and urea compounds. Furthermore, this invention relates to methods for the identification of bioactive thiourea and urea compounds as well as compositions and therapeutic methods for treating cancer.Type: ApplicationFiled: September 19, 2001Publication date: August 1, 2002Applicant: Parker Hughes InstituteInventors: Zhaohai Zhu, Chen Mao, Rama K. Narla, Fatih M. Uckun
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Patent number: 6423870Abstract: The invention concerns compounds of formula (I) in which: A forms a tricyclic system of formula A1, A2, A3 or A4; R1 represents a hydrogen atom, an alkyl, hydroxy, alkoxy or oxo group; (R2)m and (R3)m′ are such as defined in the description; n represents an integer such that 0≦n≦3; p represents an integer such as defined in the description; B represents a group (a) or (b). The invention is useful for preparing medicines.Type: GrantFiled: July 14, 2000Date of Patent: July 23, 2002Assignee: Les Laboratoires ServierInventors: Michel Langlois, Monique Mathe-Allainmat, Carole Jellimann, Jean Andrieux, Caroline Bennejean, Pierre Renard, Philippe Delagrange
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Patent number: 6362228Abstract: Novel phenylethyl-thiourea (PHET) compounds as inhibitors of reverse transcriptase and effective agents for the treatment of HIV infection, including mutant, drug-sensitive, drug-resistant, and multi-drug resistant strains of HIV.Type: GrantFiled: December 20, 2000Date of Patent: March 26, 2002Assignee: Parker Hughes InstituteInventors: Faith M. Uckun, Taracad K. Ventatachalam
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Patent number: 6316503Abstract: The invention provides compounds, compositions and methods for modulating the effects of LXR in a cell. The compounds and compositions are useful both as diagnostic indicators of LXR function and as pharmacologically active agents. The compounds and compositions find particular use in the treatment of disease states associated with cholesterol metabolism, particularly atherosclerosis and hypercholesterolemia.Type: GrantFiled: March 14, 2000Date of Patent: November 13, 2001Assignee: Tularik Inc.Inventors: Leping Li, Julio C. Medina, Kevin Lustig, Bei Shan, Hirohiko Hasegawa, Serena T. Cutler, Jiwen Liu, Liusheng Zhu