Polycyclo Ring System Patents (Class 564/270)
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Patent number: 10610473Abstract: The present invention relates to hair care compositions comprising malodor reduction compositions and methods of using such hair care compositions. Such hair care compositions comprising the malodor control technologies disclosed herein provide malodor control without leaving an undesirable scent and when perfume is used to scent such compositions, such scent is not unduly altered by the malodor control technology.Type: GrantFiled: March 23, 2017Date of Patent: April 7, 2020Assignee: The Procter and Gamble CompanyInventors: Stacy Renee Hertenstein, Judith Ann Hollingshead, Jennifer Anne Corder, James Anthony Staudigel
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Patent number: 10266481Abstract: The present invention relates to a short enantioselective synthesis of 1-amino aryl tetraline compounds of Formula 1 via nucleophilic enamine catalysis using organocatalyst such as proline. wherein R1 and R2 represent independent of each other hydrogen, (un)substituted or substituted amine; R3 and R4 represent independent of each other hydrogen or halogen.Type: GrantFiled: June 22, 2015Date of Patent: April 23, 2019Assignee: Council of Scientific & Industrial ResearchInventors: Venkataramasubramanian Vaithiyanathan, Rupali Gundappa Kalshetti, Sudalai Arumugam
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Patent number: 9005722Abstract: A color material dispersion liquid comprising a color material represented by the following general formula (I), a dispersant, and a solvent having a solubility of the color material of 0.1 (mg/10 g solvent) or less at 23° C., having excellent solvent resistance and excellent electrical reliability; a color resin composition for color filters, which can form a color layer that has high contrast, excellent solvent resistance and excellent electrical reliability; a color filter formed with the color resin composition for color filters; a liquid crystal display device having the color filter; and an organic light-emitting display device having the color filter.Type: GrantFiled: January 24, 2014Date of Patent: April 14, 2015Assignee: Dai Nippon Printing Co., Ltd.Inventor: Masato Okada
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Publication number: 20150065725Abstract: In OLEDs, improved efficiency is obtained by compounds which can form inter alia electron injection layers of the formula (I) wherein R1 is a 1-5 ring aryl (including polycyclic), aralkyl or heteroaryl group which is optionally substituted with one or more C1-C4 alkyl, alkoxy or cyano; R2 and R3 together form a 1-5 ring aryl (including polycyclic), aralkyl or heteroaryl group which is optionally substituted with C1-C4 alkyl, alkoxy or cyano; R4 is hydrogen, C1-C4 alkyl or aryl; and Ar is monocyclic, bicyclic or tricyclic aryl or heteroaryl which is optionally substituted with one or more C1-C4-alkyl or alkoxy groups, or an oligomer thereof.Type: ApplicationFiled: October 9, 2014Publication date: March 5, 2015Inventors: Poopathy KATHIRGAMANATHAN, Yun Fu CHAN
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Patent number: 8969623Abstract: A method for the preparation of Cinacalcet is disclosed comprising treating (R)-1-naphthyl ethylamine with an aromatic aldehyde to form (1R)-1-(2-naphthyl)-N-(aryl methylene)ethanamine derivative of Formula (IV), which is further treated with 1-(3-halopropyl)-3-(trifluoromethyl)benzene of Formula (V) to obtain an iminium salt of Formula (VI), followed by hydrolysis to obtain Cinacalcet free base.Type: GrantFiled: October 11, 2013Date of Patent: March 3, 2015Assignee: Amneal Pharmaceuticals, LLCInventors: Vijayavitthal Thippannachar Mathad, Navnath Chintaman Niphade, Gorakshanath Balasaheb Shinde, Sharad Subhash Ippar, Shrikant Prataprao Deshmukh, Raghavendra Kumar Panchangam
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Patent number: 8927157Abstract: Provided is a condensed polycyclic aromatic compound, having lithium ion responsivity and is suitable for lithium ion secondary battery applications, a production process thereof, a positive electrode active material containing that condensed polycyclic aromatic compound, and a positive electrode for a lithium ion secondary battery provided therewith, and further provided is a lithium ion secondary battery, having high capacity and cycling adaptability, that has the positive electrode as a constituent thereof. The condensed polycyclic aromatic compound has at least four imino groups in a molecule thereof.Type: GrantFiled: May 26, 2011Date of Patent: January 6, 2015Assignees: Kabushiki Kaisha Toyota Jidoshokki, Keio UniversityInventors: Osamu Ohmori, Akiko Shima, Hitotoshi Murase, Masataka Nakanishi, Junichi Niwa, Kimihisa Yamamoto
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Patent number: 8883325Abstract: In OLEDs, improved efficiency is obtained by compounds which can form inter alia electron injection layers of the formula (I) wherein R1 is a 1-5 ring aryl (including polycyclic), aralkyl or heteroaryl group which is optionally substituted with one or more C1-C4 alkyl, alkoxy or cyano; R2 and R3 together form a 1-5 ring aryl (including polycyclic), aralkyl or heteroaryl group which is optionally substituted with C1-C4 alkyl, alkoxy or cyano; R4 is hydrogen, C1-C4 alkyl or aryl; and Ar is monocyclic, bicyclic or tricyclic aryl or heteroaryl which is optionally substituted with one or more C1-C4-alkyl or alkoxy groups, or an oligomer thereof.Type: GrantFiled: April 27, 2012Date of Patent: November 11, 2014Assignee: Merck Patent GmbHInventors: Poopathy Kathirgamanathan, Yun Fu Chan
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Publication number: 20140274699Abstract: Described herein are methods and compositions for enhancing pathogen immunity in plants and improving plant growth.Type: ApplicationFiled: March 11, 2014Publication date: September 18, 2014Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Thomas Eulgem, Melinda Rodriguez-Salus, Colleen M. Knoth
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Publication number: 20140275582Abstract: Provided herein are novel chiral sulfinamide and imine compounds. Also provided herein are methods of synthesizing novel chiral sulfinamide and imine compounds comprising simplified purification methods when compared to prior methods. The novel chiral sulfinamide and imine compounds are useful, for example, in the synthesis of complex natural products and pharmaceutical important compounds.Type: ApplicationFiled: March 12, 2014Publication date: September 18, 2014Applicants: Texas Tech University, Nanjing University, Institute of Chemistry and Biomedical SciencesInventor: Guigen LI
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Publication number: 20140144509Abstract: The present invention relates to an organic solar cell comprising new truxequinone derivatives used as acceptor, electron transport material, and doped electron transport materials.Type: ApplicationFiled: September 5, 2011Publication date: May 29, 2014Applicant: Novaled AGInventors: Omrane Fadhel, Sascha Dorok, Horst Hartmann, Ramona Pretsch
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Publication number: 20140081048Abstract: A method for the preparation of Cinacalcet is disclosed comprising treating (R)-1-naphthyl ethylamine with an aromatic aldehyde to form (1R)-1-(2-naphthyl)-N-(aryl methylene)ethanamine derivative of Formula (IV), which is further treated with 1-(3-halopropyl)-3-(trifluoromethyl)benzene of Formula (V) to obtain an iminium salt of Formula (VI), followed by hydrolysis to obtain Cinacalcet free base.Type: ApplicationFiled: October 11, 2013Publication date: March 20, 2014Applicants: Megafine Pharma (P) Ltd., Amneal Pharmaceuticals, LLCInventors: Vijayavitthal Thippannachar Mathad, Navnath Chintaman Niphade, Gorakshanath Balasaheb Shinde, Sharad Subhash Ippar, Shrikant Prataprao Deshmukh, Raghavendra Kumar Panchangam
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Publication number: 20140046095Abstract: A method of preparing (S)-2-amino-5-methoxytetralin hydrochloride[(S)-2-amino-5-methoxyl-1,2,3,4-tetrahydronaphthalene hydrochloride], comprising the steps of: (1) producing a compound (I) by addition-elimination reaction of 5-methoxy-2-tetralone and R-(+)-a-phenylethylamine; (2) producing a compound (II) by reduction reaction of the compound (I) with a reducing agent; and (3) producing a compound (II) hydrochloride by reacting the compound (II) with a salt-forming agent, then carrying out reduction reaction with a palladium-carbon catalyst to produce (S)-2-amino-5-methoxytetralin hydrochloride. The method can significantly increase the yield of (S)-2-amino-5-methoxytetralin hydrochloride with short synthetic path, low preparation cost and less pollution, which is environmentally friendly and is suitable for medical industrialized production. The structural formulae of the compound (I) and the compound (II) are: resepectively.Type: ApplicationFiled: August 8, 2012Publication date: February 13, 2014Applicant: ANHUI KELONG INSTITUTE OF PHARMACEUTICALInventors: Qingyun HUANG, Qingguo HUANG, Meixian LOU
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Publication number: 20140039201Abstract: Color materials represented by the following general formula (I): having excellent heat resistance.Type: ApplicationFiled: April 18, 2012Publication date: February 6, 2014Applicants: YAMAMOTO CHEMICALS, INC., DAI NIPPON PRINTING CO., LTDInventors: Masato Okada, Satoshi Kinoshita
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Publication number: 20130310254Abstract: The present application relates to novel alpha, beta-unsaturated imines, to processes for their preparation, to their use for controlling animal pests including arthropods and in particular insects and to their use in the control of vectors.Type: ApplicationFiled: November 24, 2011Publication date: November 21, 2013Applicant: BAYER INTELLECTUAL PROPERTY GMBHInventors: Stefan Werner, Ulrich Ebbinghaus-Kintscher, Sebastian Horstmann, Michael Maue, Hans-Georg Schwarz, Robert Velten, Arnd Voerste, Ulrich Görgens, Andreas Turberg
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Patent number: 8575395Abstract: A method for the preparation of Cinacalcet is disclosed comprising treating (R)-1-naphthyl ethylamine with an aromatic aldehyde to form (1R)-1-(2-naphthyl)-N-(aryl methylene)ethanamine derivative of Formula (IV), which is further treated with 1-(3-halopropyl)-3-(trifluoromethyl)benzene of Formula (V) to obtain an iminium salt of Formula (VI), followed by hydrolysis to obtain Cinacalcet free base.Type: GrantFiled: September 6, 2011Date of Patent: November 5, 2013Assignees: Amneal Pharmaceuticals, LLC, Megafine Pharma (P) Ltd.Inventors: Vijayavitthal Thippannachar Mathad, Navnath Chintaman Niphade, Gorakshanath Balasaheb Shinde, Sharad Subhash Ippar, Shrikant Prataprao Deshmukh, Raghavendra Kumar Panchangam
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Publication number: 20130078514Abstract: Provided is a condensed polycyclic aromatic compound, having superior lithium ion responsivity and is suitable for lithium ion secondary battery applications, a production process thereof, a positive electrode active material containing that condensed polycyclic aromatic compound, and a positive electrode for a lithium ion secondary battery provided therewith, and further provided is a lithium ion secondary battery, having high capacity and superior cycling adaptability, that has the positive electrode as a constituent thereof. The condensed polycyclic aromatic compound according to the present invention has at least four imino groups in a molecule thereof.Type: ApplicationFiled: May 26, 2011Publication date: March 28, 2013Applicants: KEIO UNIVERSITY, KABUSHIKI KAISHA TOYOTA JIDOSHOKKIInventors: Osamu Ohmori, Akiko Shima, Hitotoshi Murase, Masataka Nakanishi, Junichi Niwa, Kimihisa Yamamoto
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Publication number: 20130060056Abstract: Embodiments of the present disclosure provide for catalysts such as those shown in FIG. 1.1 and in the Examples, methods of making catalysts, methods of using catalysts, and the like.Type: ApplicationFiled: August 31, 2012Publication date: March 7, 2013Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.Inventors: Sukwon Hong, Hwi Min Seo, David R. Snead
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Publication number: 20130041169Abstract: A catalyst composition comprising a neutral bimetallic diphenoxydiiminate complex of group 10 metals or Ni, Pd or Pt is disclosed. The compositions can be used for the preparation of homo- and co-polymers of olefinic monomer compounds.Type: ApplicationFiled: August 6, 2012Publication date: February 14, 2013Applicant: Northwestern UniversityInventors: Tobin J. Marks, Brandon A. Rodriguez, Massimiliano Delferro
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Publication number: 20130032791Abstract: Described herein are novel light absorbing conjugated polymeric electron donor materials for organic photovoltaic devices and other applications. In one embodiment, the polymer structure comprises a conjugated electron rich donor unit with an imine functionality at the bridgehead position and a conjugated electron deficient unit in the polymer backbone arranged in an alternating fashion. Monomers suitable for making the polymers, and devices utilizing the polymers, are also disclosed.Type: ApplicationFiled: June 14, 2012Publication date: February 7, 2013Inventors: Guillermo C. Bazan, Jason D. Azoulay, Bruno Caputo
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Publication number: 20130026458Abstract: To provide a composition (e.g., a coating composition) useful for forming an organic semiconductor having excellent conductivity, solvent resistance, heat resistance, durability, and other properties, and an organic semiconductor formed with the composition. The composition comprises an aromatic polycarbonyl compound having a carbonyl group as a reactive site, and at least one aromatic reactive component selected from an aromatic polyamine having an amino group as a reactive site, and an aromatic heterocyclic compound having a plurality of unmodified ?-carbon positions, as reactive sites, each of which is adjacent to a hetero atom of a heterocycl thereof. When the aromatic reactive component is an aromatic heterocyclic compound, the aromatic polycarbonyl compound is an aromatic polyaldehyde compound.Type: ApplicationFiled: April 14, 2011Publication date: January 31, 2013Applicant: DAICEL CORPORATIONInventors: Kazuhisa Fukui, Yoshinori Funaki, Mami Nobutani
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Patent number: 8299247Abstract: A material for an organic electroluminescence device including an indenofluorenedione derivative shown by the following formula (I): wherein X1 and X2, which may be the same or different, are any of specific divalent groups; R1 to R10, which may be the same or different, are a hydrogen atom, an alkyl group, an aryl group, a heterocycle, a halogen atom, a fluoroalkyl group, an alkoxy group, an aryloxy group or a cyano group; and R3 to R6 or R7 to R10 may be bonded to each other to form a ring.Type: GrantFiled: July 18, 2011Date of Patent: October 30, 2012Assignee: Idemitsu Kosan Co., Ltd.Inventor: Hironobu Morishita
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Publication number: 20120205638Abstract: In OLEDs, improved efficiency is obtained by compounds which can form inter alia electron injection layers of the formula (I) wherein R1 is a 1-5 ring aryl (including polycyclic), aralkyl or heteroaryl group which is optionally substituted with one or more C1-C4 alkyl, alkoxy or cyano; R2 and R3 together form a 1-5 ring aryl (including polycyclic), aralkyl or heteroaryl group which is optionally substituted with C1-C4 alkyl, alkoxy or cyano; R4 is hydrogen, C1-C4 alkyl or aryl; and Ar is monocyclic, bicyclic or tricyclic aryl or heteroaryl which is optionally substituted with one or more C1-C4-alkyl or alkoxy groups, or an oligomer thereof.Type: ApplicationFiled: April 27, 2012Publication date: August 16, 2012Applicant: Merck Patent GmbHInventors: Poopathy Kathirgamanathan, Yun Fu Chan
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Publication number: 20120128592Abstract: A compound for detecting an analyte using Surface Enhanced Raman Spectroscopy (SERS) and a method of forming the compound is provided. The compound has Formula I: wherein W is selected from the group consisting of an optionally substituted aryl group and an optionally substituted heteroaryl group; each Y independently is NR1R2, wherein R1 and R2 are independently selected from the group consisting of H and C1-C6 alkyl, or R1 and R2 combine to form together with the nitrogen to which they are attached a heterocyclic group with 4 to 5 carbon atoms, is used to denote a single or a double bond, and Z is NH, NH2, NH—(C?O)—(CH2)n—SH, wherein n=1 to 10, or or a tautomer or stereoisomer thereof, or a salt thereof. A method and device for detecting an analyte using Surface Enhanced Raman Spectroscopy (SERS) is also provided.Type: ApplicationFiled: October 12, 2011Publication date: May 24, 2012Inventors: Young-Tae CHANG, Kaustabh Kumar Maiti, Dinish Unnimadhava Kurup Soudamini Amma, Chit Yaw Fu, Malini Olivo, Kiat Seng Jason Soh, Seong-Wook Yun
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Patent number: 8119830Abstract: Disclosed are UV absorbers that contain a labile functional group capable of initiating free radical polymerization.Type: GrantFiled: March 11, 2010Date of Patent: February 21, 2012Assignee: Novartis AGInventor: Douglas C. Schlueter
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Publication number: 20110319663Abstract: A method for the preparation of Cinacalcet is disclosed comprising treating (R)-1-naphthyl ethylamine with an aromatic aldehyde to form (1R)-1-(2-naphthyl)-N-(aryl methylene)ethanamine derivative of Formula (IV), which is further treated with 1-(3-halopropyl)-3-(trifluoromethyl)benzene of Formula (V) to obtain an iminium salt of Formula (VI), followed by hydrolysis to obtain Cinacalcet free base.Type: ApplicationFiled: September 6, 2011Publication date: December 29, 2011Applicant: Amneal Pharmaceuticals, LLCInventors: Vijayvitthal Thippannachar Mathad, Navnath Chintaman Niphade, Gorakshanath Balasaheb Shinde, Sharad Subhash Ippar, Shrikant Prataprao Deshmukh, Ragavendra Kumar Panchangam
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Publication number: 20110275814Abstract: A material for an organic electroluminescence device including an indenofluorenedione derivative shown by the following formula (I): wherein X1 and X2, which may be the same or different, are any of specific divalent groups; R1 to R10, which may be the same or different, are a hydrogen atom, an alkyl group, an aryl group, a heterocycle, a halogen atom, a fluoroalkyl group, an alkoxy group, an aryloxy group or a cyano group; and R3 to R6 or R7 to R10 may be bonded to each other to form a ring.Type: ApplicationFiled: July 18, 2011Publication date: November 10, 2011Applicant: IDEMITSU KOSAN CO., LTD.Inventor: Hironobu MORISHITA
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Publication number: 20110124831Abstract: The present invention relates to a self-assembled olefin polymerization catalyst comprising a transition metal compound according to formula (I) LqMmXn wherein M is a transition metal selected from the group consisting of Group 3-11 of the periodic table; X is independently selected from the group consisting of H, halogen, CN, optionally substituted N(Ra)2, OH, optionally substituted C1-C20 alkyl, optionally substituted C1-C20 alkoxy, wherein Ra is independently selected from the group consisting of optionally substituted C1-C20 alkyl, optionally substituted C6-C20 aryl and halogen; q is an integer of at least 2; m is an integer of at least 2; n is an integer making (I) electrically neutral; L is independently a ligand which has at least two linked coordination units, wherein each coordination unit binds to a different transition metal.Type: ApplicationFiled: January 14, 2008Publication date: May 26, 2011Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCHInventor: He-Kuan Luo
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Publication number: 20110082053Abstract: Provided is a molecular rectifier comprised of a diamondoid molecule and an electron acceptor attached to the diamondoid molecule. The electron acceptor is generally an electron accepting aromatic species which is covalently attached to the diamondoid.Type: ApplicationFiled: January 30, 2009Publication date: April 7, 2011Inventors: Wanli Yang, Zhi-Xun Shen, Harindran C. Manoharan, Nicholas A. Melosh, Michael A. Kelly, Andrey A. Fokin, Peter R. Schreiner, Jason C. Randel
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Publication number: 20110065766Abstract: The present invention relates, in part, to methods of treatment, prevention, and inhibition of viral disorders. In one aspect, the present invention relates to inhibition of the M2 proton channel of influenza viruses (e.g. influenza A virus) and other similar viroporins (e.g., VP24 of Ebola and Marburg viruses; and NS3 protein of Bluetongue). The present invention further relates, inter alia, to compounds which have been shown to possess antiviral activity, in particular, inhibiting the M2 proton channel of influenza viruses.Type: ApplicationFiled: September 13, 2010Publication date: March 17, 2011Inventors: Jizhou Wang, Xiaodong Fan, Lidia Cristian
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Publication number: 20110065762Abstract: The present invention relates, in part, to methods of treatment, prevention, and inhibition of viral disorders. In one aspect, the present invention relates to inhibition of the M2 proton channel of influenza viruses (e.g. influenza A virus) and other similar viroporins (e.g., VP24 of Ebola and Marburg viruses; and NS3 protein of Bluetongue). The present invention further relates, inter alia, to compounds which have been shown to possess antiviral activity, in particular, inhibiting the M2 proton channel of influenza viruses.Type: ApplicationFiled: September 13, 2010Publication date: March 17, 2011Inventors: Jizhou Wang, Xiaodong Fan, Lidia Cristian
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Publication number: 20100327264Abstract: In OLEDs, improved efficiency is obtained by novel compounds which can form inter alia electron injection layers of the formula (I) wherein R1 is a 1-5 ring aryl (including polycyclic), aralkyl or heteroaryl group which is optionally substituted with one or more C1-C4 alkyl, alkoxy or cyano; R2 and R3 together form a 1-5 ring aryl (including polycyclic), aralkyl or heteroaryl group which is optionally substituted with C1-C4 alkyl, alkoxy or cyano; R4 is hydrogen, C1-C4 alkyl or aryl; and Ar is monocyclic, bicyclic or tricyclic aryl or heteroaryl which is optionally substituted with one or more C1-C4-alkyl or alkoxy groups, or an oligomer thereof.Type: ApplicationFiled: December 19, 2007Publication date: December 30, 2010Applicant: MERCK PATNET GMBHInventors: Poopathy Kathirgamanathan, Yun Fu Chan
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Patent number: 7759504Abstract: A triarylamine derivative is represented by the following Formula (I). In Formula (I): R111, R112, R121 and R122 each independently represent a hydrogen atom, an aliphatic group or an aromatic group, R113, R114, R115, R116, R123, R124, R125 and R126 each independently represent a hydrogen atom or a substituent, provided that at least one pair among R111 and R121, R112 and R122, R113 and R123, R114 and R124, R115 and R125 and R116 and R126 includes two different groups; at least one ring may be formed by mutual bonding in at least one pair among R111 and R112, R111 and R114, R113 and R114, R113 and R123, R123 and R124, R121 and R124, R121 and R122, and two R116s which are respectively bound to different phenyl groups; Xm? represents an m-valent anion; m and n represent 1 or 2; and a product of in and n is 2.Type: GrantFiled: April 10, 2008Date of Patent: July 20, 2010Assignee: Fujifilm CorporationInventors: Tomohito Masaki, Keizo Kimura, Osamu Uchida
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Publication number: 20100130742Abstract: Compounds of the formula I, II or III: or pharmaceutically acceptable salts thereof, wherein m, n, q, Ar, R1, R2, R3, R4 and R5 are as defined herein. Also provided are methods for preparing, compositions comprising, and methods for using compounds of formulas I-III.Type: ApplicationFiled: January 26, 2010Publication date: May 27, 2010Inventors: Ralph New Harris, III, James M. Kress, David Bruce Repke, Russell Stephen Stabler
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Publication number: 20090298898Abstract: Compounds of formula wherein A0, A1 and A2 are each independently of the others a bond or a C1-C6alkylene bridge; A3 is a C1-C6alkylene bridge which is unsubstituted or substituted by from one to six identical or different substituents selected from halogen and C3-C8cycloalkyl; Y is, for example, O, S, SO or SO2; M is O or NOR6, X1 and X2 are each independently of the other fluorine, chlorine or bromine; R1, R2 and R3 are, for example, H, halogen, OH, SH, CN, nitro, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkylcarbonyl, C2-C6alkenyl, C2-C6haloalkenyl or C2-C6alkynyl; Q is, for example, O, S, SO or SO2; W is, for example, O, S, SO, SO2, —C(?O)—O— or —O—C(?O)—; T is, for example, a bond, O, S, SO, SO2, —C(?O)—O— or —O—C(?O)—; D is CH or N; R4 is, for example, H, halogen, OH, SH, CN, nitro, C1-C6alkyl or C1-C6haloalkyl; R5 is, for example, C1-C12alkyl, C3-C8cycloalkyl or —N(R7)2; R7 is H, C1-C6alkyl, C1-C3haloalkyl, C1-C6alkylcarbonyl, C1-C3haloalkylcarbonyl, C1-C6alkoxycarbonyl, C3-C8cycloalkyl, C3-C8 cycloalkylType: ApplicationFiled: July 31, 2009Publication date: December 3, 2009Applicant: SYNGENTA CROP PROTECTION, INC.Inventors: Werner Zambach, Roger Graham Hall, Peter Renold, Stephan Trah
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Publication number: 20090137681Abstract: Provided herein are compositions and methods for treating or preventing cancer and autoimmune diseases. Compositions comprise a sirtuin inhibitory compound that decreases the activity of a sirtuin, such as SIRT1 or Sir2. Exemplary methods comprise contacting a cell or a molecule with a sirtuin inhibitory compound that decreases the activity of a sirtuin and thereby reduces the life span of a cell, kills the cell or renders it susceptible to certain cell stresses including radiation and chemotherapy. Other methods include treating pathogens expressing a sirtuin.Type: ApplicationFiled: April 6, 2006Publication date: May 28, 2009Inventors: David A Sinclair, Antonello Mai
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Publication number: 20080255388Abstract: A triarylamine derivative is represented by the following Foimula (I). In Formula (I): R111, R112, R121, R122, R131 and R132 each independently represent a hydrogen atom, an aliphatic group or an aromatic group, provided that R131 and R132 are not both phenyl groups having a group represented by —NR141R142 at a fourth position; R141 and R142 each independently represent a hydrogen atom, an aliphatic group, or an aromatic group; R113, R123 and R133 each independently represent a substituent; n113, n123 and n133 each independently represent an integer of from 0 to 4; and X? represents a counteranion represented by any of the following Formulae (II) to (IV). In Formulae (II) to (IV), R211, R212, R311, R312, R411, R412 and R413 each independently represent an aliphatic group, an aromatic group or a heterocyclic group.Type: ApplicationFiled: April 10, 2008Publication date: October 16, 2008Inventors: Tomohito MASAKI, Keizo Kimura, Osamu Uchida
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Publication number: 20080255387Abstract: A triarylamine derivative is represented by the following Formula (I). In Formula (I): R111, R112, R121 and R122 each independently represent a hydrogen atom, an aliphatic group or an aromatic group, R113, R114, R115, R116, R123, R124, R125 and R126 each independently represent a hydrogen atom or a substituent, provided that at least one pair among R111 and R121, R112 and R122, R113 and R123, R114 and R124, R115 and R125 and R116 and R126 includes two different groups; at least one ring may be formed by mutual bonding in at least one pair among R111 and R112, R111 and R114, R113 and R114, R113 and R123, R123 and R124, R121 and R124, R121 and R122, and two R116s which are respectively bound to different phenyl groups; Xm? represents an m-valent anion; m and n represent 1 or 2; and a product of in and n is 2.Type: ApplicationFiled: April 10, 2008Publication date: October 16, 2008Inventors: Tomohito MASAKI, Keizo Kimura, Osamu Uchida
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Patent number: 7176334Abstract: A process for the preparation of substituted halogenated anilines from substituted halogenated 1-chlorobenzenes which comprises a) reacting a substituted halogenated 1-chlorobenzene selectively with an imine in the presence of a transition metal catalyst complex and a base to form an N-aryl imine; b) hydrolyzing the N-aryl imine; and c) isolating the substituted halogenated aniline.Type: GrantFiled: December 16, 2003Date of Patent: February 13, 2007Assignee: BASF AktiengesellschaftInventors: Jonathan O. Smith, Melissa A. Petruska, Jon J. Longlet
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Patent number: 7049378Abstract: Olefins, such as ethylene, are polymerized using as a polymerization catalyst a complex of a selected transition metal with a monoanionic ligand that has at least three atoms that may coordinate to the transition metal. Also disclosed are the above selected transition metal complexes, and intermediates thereto.Type: GrantFiled: December 9, 2002Date of Patent: May 23, 2006Assignee: E. I. du Pont de Nemours and CompanyInventors: Steven Dale Ittel, Ying Wang
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Patent number: 6914078Abstract: Disclosed are compounds having one of the following structures: wherein R and R? are hydrogen or substituted or unsubstituted C1 to C6 linear or branched alkyl, and at least one X is a halogen atom, pharmaceutical compositions containing the compounds as active ingredients, and methods for using the compounds in the photodynamic treatment of cancers.Type: GrantFiled: February 25, 2003Date of Patent: July 5, 2005Assignee: Wisconsin Alumni Research FoundationInventor: Guilherme L. Indig
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Patent number: 6806386Abstract: The present invention relates to a process for the preparation of compounds of formula (1), in which R1, R2 and R3 independently of one another are hydrogen, halogen , trifluoromethyl of or C1-C4alkoxy, wherein a compound of formula (2), in which R1, R2 and R3 are as defined in formula (1), is reacted with methlyamine in the presence of a non-alcoholic solvent and, if desired, in the presence of a sulfonic acid catalyst to give the compound of formula (2) and, if desired, is subject to purification by recrystallization.Type: GrantFiled: May 14, 2002Date of Patent: October 19, 2004Assignee: Ciba Specialty Chemicals CorporationInventors: Marc Thommen, Andreas Hafner, Frédëric Brunner, Hans-Jörg Kirner, Roman Kolly
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Patent number: 6696038Abstract: A biodegradable, novel cationic lipopolymer comprising a branched polyethylenimine(PEI), a cholesterol derived lipid anchor, and a biodegradable linker which covalently links the branched PEI and cholesterol derived lipid anchor. One example of such a novel lipolymer is poly{(ethylene imine)-co-[N-2-aminoehtyl)ethylene imine]-co-[N-(N-cholesteryloxycabonyl-(2-aminoethyl))ethylene imine]} (“PEACE”). The cationic lipopolymers in the present invention can be used in drug delivery and are especially useful for delivery of a nucleic acid or any anionic bioactive agent to various organs and tissues after local or systemic administration. Methods of preparing and using the cationic lipopolymer gene carriers of the present invention to efficiently transfect cells, both in vitro and in vivo, are disclosed.Type: GrantFiled: September 14, 2000Date of Patent: February 24, 2004Assignee: Expression Genetics, Inc.Inventors: Ram I. Mahato, Sang-Oh Han, Darin Y. Furgeson
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Patent number: 6693218Abstract: Described is a process for the preparation of compounds of formula (1a) which comprises reacting an isomeric mixture consisting of from 75 to 95% of compound of formula (2a) and from 5 to 25% of a compound of formula (2b) with methylamine, in a suitable solvent, to form a sertraline-imine isomeric mixture consisting of from 75 to 95% of formula (1a) and from 5 to 25% of formula (1b)(A1), or reacting an isomeric mixture consisting of from 75 to 95% of a compound of formula (2a) and from 5 to 25% of a compound of formula (2b) with methylamine, in a suitable solvent, using suitable methods of isolation to form an enriched sertraline-imine isomeric mixture, consisting of >99% of a compound of formula (1a) and <1% of a compound of formula (1b)(A2); and then subjecting the sertraline-imine isomeric mixture obtained according to reaction route (A1) or (A2), in a suitable solvent, to recrystallisation (B), in accordance with scheme (I) wherein in formula (1a), R1, R2 and R3 are each independently of the othersType: GrantFiled: September 20, 2002Date of Patent: February 17, 2004Assignee: Ciba Specialty Chemicals CorporationInventors: Marc Thommen, Andreas Hafner, Roman Kolly, Hans-Jörg Kirner, Frédéric Brunner
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Patent number: 6593496Abstract: This invention relates to a novel improved process for preparing the (+) enantiomer of N-[4(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenylidene]methanamine by reacting the (+) enantiomer of 4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenone with monomethylamine and titanium chloride or molecular sieves.Type: GrantFiled: May 30, 2000Date of Patent: July 15, 2003Assignee: Pfizer IncInventor: George H. Quallich
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Patent number: 6531424Abstract: Olefins, such as ethylene, are polymerized using as a polymerization catalyst a complex of a selected transition metal with a monoanionic ligand that has at least three atoms that may coordinate to the transition metal. Also disclosed are the above selected transition metal complexes, and intermediates thereto.Type: GrantFiled: December 13, 2000Date of Patent: March 11, 2003Assignee: E. I. du Pont de Nemours and CompanyInventors: Steven Dale Ittel, Ying Wang
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Publication number: 20030013768Abstract: A pharmaceutical intermediate, N-[4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenylidene]methanamine, which can be used in the production of sertraline hydrochloride, is conveniently prepared by reacting 4-(3,4-dichlorophenyl)-3,4-dihydro-1-(2H)-naphthalenone with monomethylamine in a solvent which is an amide solvent with a structure of general formula IV: 1Type: ApplicationFiled: May 31, 2002Publication date: January 16, 2003Applicant: ORION COPRORATION FERMIONInventors: Ilpo Laitinen, Pekka Pietikaeinen
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Patent number: 6495485Abstract: Single-site catalysts useful for polymerizing olefins are disclosed. The organometallic catalysts incorporate a Group 3 to 10 transition, lanthanide or actinide metal and a caged diimide ligand. The diimide ligands are made by a tandem Diels-Alder and photochemical [2+2] cycloaddition sequence to give a multicyclic dione, followed by condensation with a primary amine. Because a wide variety of caged diimide ligands are easy to prepare from commercially available dienes and dienophiles, the invention enables the preparation of a new family of single-site catalysts. Based on their unique structure and geometry, the catalysts offer polyolefin producers new ways to improve activity, control comonomer incorporation, or regulate polyolefin tacticity.Type: GrantFiled: April 8, 2002Date of Patent: December 17, 2002Assignee: Equistar Chemicals, LPInventors: Gregory G. Hlatky, Jonathan L. Schuchardt
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Patent number: 6268520Abstract: Novel tricyclic compounds of formula I as defined in the specification, a process for their preparation and their use for the preparation of optically active or racemic colchicine and thiocolchicine derivatives.Type: GrantFiled: April 5, 1999Date of Patent: July 31, 2001Assignee: Hoechst Marion RousselInventors: Francis Brion, Bernadette Chappert, Christian Diolez, Christian Marie, Alain Mazurie, Michel Middendorp, Didier Pronine, Edmond Toromanoff
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Patent number: 6232500Abstract: This invention relates to a novel improved process for preparation of N-[4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenylidene]methanamine from 4-(3,4-dichloro-phenyl)-3,4-dihydro-1(2H)-naphthalenone and monomethylamine.Type: GrantFiled: September 2, 1999Date of Patent: May 15, 2001Assignee: Pfizer IncInventors: Juan Carlos Colberg, David Michael Pfisterer, Geraldine Patricia Taber
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Patent number: 6222046Abstract: The invention has disclosed a trifluoroacetoxylation agent and a preparation process of the agent, which is safe and ease to handle, very useful in industry, and represented by the formula (1); wherein R1 to R4 are a substituted or unsubstituted, saturated or unsaturated alkyl group or a substituted or unsubstituted aryl group and can be the same or different, R1 and R2 or R3 and R4 can bond to form a ring containing a nitrogen atom or a nitrogen atom and other hetero atoms, and R1 and R3 can bond to form a ring containing a nitrogen atom or a nitrogen atom and other hetero atoms.Type: GrantFiled: August 9, 1999Date of Patent: April 24, 2001Assignee: Mitsui Chemicals, Inc.Inventors: Hidetoshi Hayashi, Hiroshi Sonoda, Kenichi Goto, Kouki Fukumura, Junko Naruse, Teruyuki Nagata