Amine Oxides Patents (Class 564/297)
  • Publication number: 20150114884
    Abstract: Treatment compositions for neutralizing acidic species and reducing hydrochloride and amine salts in a fluid hydrocarbon stream are disclosed. The treatment compositions may comprise at least one amine with a salt precipitation potential index of equal to or less than about 1.0. Methods for neutralizing acidic species and reducing deposits of hydrochloride and amine salts in a hydrocarbon refining process are also disclosed. The methods may comprise providing a fluid hydrocarbon stream and adding a treatment composition to the fluid hydrocarbon stream. The treatment compositions used may have a salt precipitation potential index of equal to or less than about 1.0 and comprise either water-soluble or oil-soluble amines.
    Type: Application
    Filed: October 31, 2013
    Publication date: April 30, 2015
    Applicant: General Electric Company
    Inventors: Alagarsamy Subbiah, Rebika Mayanglambam Devi, Nimeshkumar Kantilal Patel, Muthukumar Nagu, Rhomit Ghosh, Sathees Kesavan, Ashok Shankar Shetty, Manish Joshi
  • Publication number: 20150087717
    Abstract: The antimicrobial composition of the present invention comprises a cationic active ingredient, a quaternized sugar-derived surfactant, and an optional foam boosting surfactant. These formulations have a high cidal activity in a short amount of time and provide stable copious foam. The formulations of the present invention also exhibit enhanced tissue (e.g. skin) compatibility as defined by an in vitro whole toxicology assessment method.
    Type: Application
    Filed: December 5, 2014
    Publication date: March 26, 2015
    Inventors: Daniel E. Pedersen, Angela R. Eder, Charles Allen Hodge
  • Publication number: 20140274857
    Abstract: The present invention relates to the field of membrane separation processes and clean in place compositions for cleaning such membranes. The cleaning compositions can remove proteins, fats, and other food, beverage, and brewery based soils and offer an environmentally friendly alternative surfactant system to NPE. According to the invention, surfactants and polymers useful for this process are unpredictable and specific surfactants, polymers, and combinations of the same are disclosed for use alone, as part of a cleaning composition. Methods of use of the same are also included.
    Type: Application
    Filed: March 12, 2013
    Publication date: September 18, 2014
    Applicant: ECOLAB USA INC.
    Inventors: Paul Schacht, Jeffrey Weilage, Eric Schmidt, Joseph P. Curran, Ralf Krack, Victor Fuk-Pong Man, Charles Allen Hodge
  • Patent number: 8796175
    Abstract: The invention relates to the use of at least one compound selected from the class of the sulphoximines for enhancing plants' intrinsic defenses and/or for improving plant growth and/or for enhancing the resistance of plants to plant diseases which are caused by fungi, bacteria, viruses, MLOs (mycoplasma-like organisms) and/or RLOs (rickettsia-like organisms), and/or for enhancing the resistance of plants to abiotic stress factors.
    Type: Grant
    Filed: August 17, 2009
    Date of Patent: August 5, 2014
    Assignee: Bayer CropScience AG
    Inventors: Peter Jeschke, Wolfgang Thielert, Heike Hungenberg
  • Patent number: 8669398
    Abstract: The invention relates to novel O-dialkylamino-isoureas and polymerizable compositions comprising these O-dialkylamino-isoureas of compounds of the general formula (I). The invention further relates to the use of O-dialkylamino-isoureas as polymerization initiators, especially to prepare coatings or for controlled degradation of polyolefins.
    Type: Grant
    Filed: December 28, 2009
    Date of Patent: March 11, 2014
    Assignee: BASF SE
    Inventors: Peter Nesvadba, Lucienne Bugnon Folger, Antoine Carroy, Marc Faller
  • Publication number: 20130252868
    Abstract: The present invention relates to a liquid cleaning and disinfecting composition and, in one embodiment, a liquid cleaning and disinfecting liquid hand dishwashing composition, comprising an alkyl or substituted alkyl branched alkyl chain amine oxide. The present invention further relates to methods of disinfecting dishware and/or dishwashing implements and/or skin using such a liquid detergent compositions.
    Type: Application
    Filed: March 23, 2012
    Publication date: September 26, 2013
    Inventors: Jamila Tajmamet, Jean-Luc Philippe Bettiol, Robby Renilde François Keuleeers
  • Publication number: 20130202567
    Abstract: The present disclosure provides cell culture medium comprising trimethylamine N-oxide (TMAO). Progenitor cells cultured with such medium can form connective tissue with enhanced mechanical properties. Also provided are methods of forming connective tissue and methods of treatment for connective tissue defects.
    Type: Application
    Filed: June 17, 2011
    Publication date: August 8, 2013
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Clark T. Hung, Grace D. O'Connell
  • Patent number: 8366914
    Abstract: Compounds having the formulae and general formulae: wherein each R1, R2, R3 and R4 are the same or different and may be hydrogen, an alkyl group, an aryl group, a halogen, a nitro group, an alkyl or aryl ester, and an alkyl or aryl ether; compounds having the general formula: wherein R is an alkyl, aryl or electron withdrawing group; mixtures thereof; can be used as additives for crude oil and hydrocarbons. These compounds may be used to scavenge mercaptans, sulfides, cyanides, and primary or secondary amines; either alone or in combination.
    Type: Grant
    Filed: October 14, 2008
    Date of Patent: February 5, 2013
    Assignee: Baker Hughes Incorporated
    Inventors: Jianzhong Yang, Tauseef Salma, John A. Schield, Jerry J. Weers, Joseph L. Stark
  • Patent number: 8299304
    Abstract: This invention provides alignment materials for liquid crystal display device of vertical alignment mode and methods for the preparation of the same, and more particularly, it provides diaminobenzene derivatives represented by the following formula 1 (shown in description), capable of aligning liquid crystal in uniform and vertical way and remarkably improving clarity and solubility against organic solvents, methods for the preparation of the same and liquid crystal alignment films using the same.
    Type: Grant
    Filed: February 9, 2007
    Date of Patent: October 30, 2012
    Assignee: Dongjin Semichem Co., Ltd.
    Inventors: Jin wook Choi, Dal bong Seo, Jae cheol Park, Yong bae Kim
  • Publication number: 20120214722
    Abstract: There are provided a processing liquid for suppressing pattern collapse of a fine metal structure, containing at least one member selected from the group consisting of an ammonium halide having a fluoroalkyl group, a betaine compound having a fluoroalkyl group, and an amine oxide compound having a fluoroalkyl group, and a method for producing a fine metal structure using the same.
    Type: Application
    Filed: October 19, 2010
    Publication date: August 23, 2012
    Applicant: MITSUBISHI GAS CHEMICAL COMPANY INC.
    Inventors: Masaru Ohto, Hiroshi Matsunaga, Kenji Yamada
  • Patent number: 8227517
    Abstract: Methods are provided for using doxorubicin active agents in which reduced host toxicity is observed. Aspects of the methods including administering to a subject an effective amount of a doxorubicin active agent in conjunction with a doxorubicin toxicity-reducing adjuvant, e.g., a nitrone compound, or a nitrone compound in combination with a bisdioxopiperazine compound. Also provided are compositions for use in practicing the subject methods. The methods and compositions find use in a variety of different applications, including in the treatment of a variety of different disease conditions.
    Type: Grant
    Filed: February 11, 2009
    Date of Patent: July 24, 2012
    Assignee: Tosk, Incorporated
    Inventors: William A. Garland, Brian D. Frenzel
  • Publication number: 20120058144
    Abstract: The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having the following structures XIV or XVII.
    Type: Application
    Filed: November 10, 2009
    Publication date: March 8, 2012
    Applicant: ALNYLAM PHARMACEUTICALS, INC.
    Inventors: Muthiah Manoharan, Kallanthottathil G. Rajeev, Muthusamy Jayaraman, David Butler, Jayaprakash K. Narayanannair, Marco A. Ciufolini
  • Publication number: 20120004382
    Abstract: In a process for the aqueous suspension polymerization of vinyl chloride, alone or in mixture with other monomers, in the presence of at least one of dialkylperoxydicarbonate, peroxyester and diacyl peroxide, the polymerization composition according to the invention comprises at least one dialkylhydroxylamine as a shortstopping agent along with a totally or partially hindered phenolic antioxidant.
    Type: Application
    Filed: January 20, 2010
    Publication date: January 5, 2012
    Applicant: TAMINCO
    Inventor: Nicholas M. Martyak
  • Publication number: 20110287436
    Abstract: Methods of detecting at least one analyte and at least one nucleic acid in a sample are provided. Reagents for carrying out the methods are also provided.
    Type: Application
    Filed: July 29, 2011
    Publication date: November 24, 2011
    Applicant: Applied Biosystems, LLC
    Inventors: Mark E. Shannon, David W. Ruff
  • Publication number: 20110280863
    Abstract: Methods, kits and compounds are provided that relate to the diagnosis, treatment, and/or prevention of preeclampsia.
    Type: Application
    Filed: November 2, 2009
    Publication date: November 17, 2011
    Applicants: Regents of the University of California, The, Yale University
    Inventors: Catalin S. Buhimschi, Irina Buhimschi, Charles G. Glabe
  • Publication number: 20110257436
    Abstract: Process for the manufacture of solid Mn+(HDO)n salts wherein HDO is the anion of N?-hydroxy-N-cyclohexyldiazenium oxide, and Mn+ is a metal cation by precipitation with an acid from an alkaline solution of an HDO-salt with monovalent cations in the presence of amines and drying under mild conditions.
    Type: Application
    Filed: December 10, 2009
    Publication date: October 20, 2011
    Applicant: BASF SE
    Inventors: Darren Michael Hodgkinson, James Bullock, Mohammed Shoaib Qureshi
  • Publication number: 20110206630
    Abstract: The invention provides a surfactant and/or a cleaning composition comprising a microbially produced branched fatty alcohol or a derivative thereof. The invention also provides a household cleaning composition and a personal or pet care cleaning composition comprising a microbially produced branched fatty alcohol or a derivative thereof.
    Type: Application
    Filed: February 14, 2011
    Publication date: August 25, 2011
    Applicant: LS9, Inc.
    Inventor: Mathew Rude
  • Publication number: 20110118451
    Abstract: Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
    Type: Application
    Filed: January 13, 2011
    Publication date: May 19, 2011
    Applicant: Ambrx, Inc.
    Inventors: Zhenwei Miao, Junjie Liu, Thea Norman, Russell Driver
  • Publication number: 20110071270
    Abstract: Silicone polyoxamide and silicone polyoxamide-hydrazide copolymers comprise at least two repeating units of formula I In this formula, each R1 is independently an alkyl, haloalkyl, aralkyl, alkenyl, aryl, or aryl substituted with an alkyl, alkoxy, or halo; each Y is independently an alkylene, aralkylene, or a combination thereof; each G is independently a bond or a divalent residue equal to a diamine of formula R3HN-G-NHR3 minus the two —NHR3 groups; each R3 is independently hydrogen or alkyl or R3 taken together with G and with the nitrogen to which they are both attached form a heterocyclic group; each n is independently an integer of 0 to 1500; each p is independently an integer of 1 to 10, and the average of p is 1.2 or greater; and each q is independently an integer of 1 or greater, and every q is not the same integer.
    Type: Application
    Filed: September 21, 2009
    Publication date: March 24, 2011
    Inventors: David S. HAYS, Richard G. HANSEN, Stephen A. JOHNSON, Benjamin J. BENDING, Kyle J. LINDSTROM
  • Publication number: 20100227931
    Abstract: The present invention provides the antifungal composition, containing the compound (a) selected from specific quaternary ammonium salts and specific amine oxides and the sequestering agent (b) having a calcium-chelating constant of 4 to 12 at a mass ratio (a)/(b) of 0.01 to 10.
    Type: Application
    Filed: October 23, 2008
    Publication date: September 9, 2010
    Applicant: Kao Corporation
    Inventors: Youichi Kuwano, Akira Ishikawa, Atsushi Tanaka
  • Publication number: 20100168422
    Abstract: Provided herein are compounds and methods useful for preparing hexahydrofuro[2,3-b]furan-3-ol. Hexahydrofuro[2,3-b]furan-3-ol can be efficiently synthesized in four steps from readily available starting materials.
    Type: Application
    Filed: December 30, 2008
    Publication date: July 1, 2010
    Inventor: Weiping Chen
  • Publication number: 20100113807
    Abstract: A solid phase reaction system for oxidation of an organic compound, having high industrial value in which an organic solvent exerting a reverse influence on earth environments is not necessary, reuse of a catalyst is possible, and high yield can be attained, comprising a mixture of a powdery dispersion medium and a powder of a solid catalyst for the above-described oxidation reaction, and the above-described organic compound and aqueous hydrogen peroxide, wherein the above-described organic compound, the above-described solid catalyst and the above-described aqueous hydrogen peroxide are dispersed in the above-described mixture so that they get into contact mutually.
    Type: Application
    Filed: January 30, 2008
    Publication date: May 6, 2010
    Applicant: OSAKA UNIVERSITY
    Inventors: Jyunko Ichihara, Syunrou Yamaguchi
  • Patent number: 7538248
    Abstract: An amine oxide type surfactant, which has excellent compatibility with an anionic or non-ionic surfactant having excellent detergency and shows excellent detergency and softening effect, is represented by the following formula 1: wherein R1 and R2 are the same or different, and each independently represents a C8˜C22 linear or branched alkyl or alkenyl group; A represents a C1˜C4 alkyl, alkenyl or hydroxyalkyl group; X represents OH, a C1˜C4 alkyl, hydroxyalkyl, (CH2CH2O)nH, (CHCH3CH2O)nH or a combination of (CH2CH2O)nH and (CHCH3CH2O)nH; and n is a number of 1˜30.
    Type: Grant
    Filed: August 21, 2007
    Date of Patent: May 26, 2009
    Assignee: Aekyung Industrial Co., Ltd.
    Inventors: In Sub Baik, In Shik Cho, Gyeong Yup Ghi, Dong Sung Han
  • Publication number: 20090095658
    Abstract: Compounds having the formulae and general formulae: wherein each R1, R2, R3 and R4 are the same or different and may be hydrogen, an alkyl group, an aryl group, a halogen, a nitro group, an alkyl or aryl ester, and an alkyl or aryl ether; compounds having the general formula: wherein R is an alkyl, aryl or electron withdrawing group; mixtures thereof; can be used as additives for crude oil and hydrocarbons. These compounds may be used to scavenge mercaptans, sulfides, cyanides, and primary or secondary amines; either alone or in combination.
    Type: Application
    Filed: October 14, 2008
    Publication date: April 16, 2009
    Applicant: BAKER HUGHES INCORPORATED
    Inventors: Jianzhong Yang, Tauseef Salma, John A. Schield, Jerry J. Weers, Joseph L. Stark
  • Publication number: 20080293678
    Abstract: The invention describes compositions and kits comprising at least qrie organic nitric oxide enhancing salt of an angiotensin converting enzyme inhibitor, and, optionally, at least one nitric oxide enhancing compound and/or at least one therapeutic agent. The invention also provides methods for (a) treating cardiovascular diseases; (b) treating renovascular diseases; (c) treating diabetes; (d) treating diseases resulting from oxidative stress; (e) treating endothelial dysfunctions; (f) treating diseases caused by endothelial dysfunctions; (g) treating cirrhosis; (h) treating pre-eclampsia; Q) treating osteoporosis; (k) treating nephropathy; (l) treating peripheral vascular diseases; (m) treating portal hypertension; (n) treating ophthalmic disorders; (o) treating metabolic syndrome; and (p) treating hyperlipidemia.
    Type: Application
    Filed: March 17, 2006
    Publication date: November 27, 2008
    Applicant: NitroMed, Inc.
    Inventor: David S. Garvey
  • Patent number: 7176242
    Abstract: Disclosed are compounds of the formula wherein the variables RN, RC, R1, R25, R2, and R3 are as defined herein. These compounds have activity as inhibitors of beta-secretase and are therefore useful in treating a variety of discorders such as Alzheimer's Disease.
    Type: Grant
    Filed: November 8, 2002
    Date of Patent: February 13, 2007
    Assignees: Elan Pharmaceuticals, Inc., Pharmacia & Upjohn Company
    Inventors: Varghese John, Michel Maillard, Barbara Jagodzinska, James Beck, Andrea Gailunas, John Freskos, John Mickelson, Lakshman Samala, Jennifer Sealy, Ruth TenBrink, Lawrence Fang, Roy Hom
  • Patent number: 6906104
    Abstract: The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
    Type: Grant
    Filed: June 13, 2002
    Date of Patent: June 14, 2005
    Assignee: Pharmacia & Upjohn Company
    Inventors: Heinrich Josef Schostarez, Robert Alan Chrusciel
  • Patent number: 6900172
    Abstract: The present invention relates to methods for using amine oxide monomer-containing polymeric suds enhancers (enhancers) to increase the suds and/or foam volume and suds and/or foam retention in suds-forming and/or foam-forming compositions comprising such amine oxide monomer-containing polymeric suds enhancers. Suitable suds-forming and/or foam-forming compositions comprise one or more amine oxide monomer-containing polymeric suds enhancers.
    Type: Grant
    Filed: October 8, 2003
    Date of Patent: May 31, 2005
    Assignee: Procter & Gamble Company
    Inventors: Mark Robert Sivik, Jean-Francois Bodet, Bernard William Kluesener, William Michael Scheper, Dominic Wai-Kwing Yeung, Vance Bergeron
  • Publication number: 20040224366
    Abstract: Molecules comprising aminooxy groups are provided, wherein the aminooxy groups provide attachment sites for the covalent attachment of other molecules. In one embodiment, polyoxyethylene molecules comprising aminooxy groups are provided that can be conjugated to wide variety of biologically active molecules including poly(amino acids). In another embodiment, valency platform molecules comprising aminooxy groups are provided. The aminooxy groups can be used to form covalent bonds with biological molecules such as poly(amino acids). The aminooxy groups can, for example, react with poly(amino acids) modified to contain carbonyl groups, such as glyoxyl groups, to form a conjugate of the valency platform molecule and the biologically active molecule via an oxime bond. The valency platform molecules comprising aminooxy groups are advantageously reactive in the formation of conjugates, and they also can be readily synthesized to form a composition with very low polydispersity.
    Type: Application
    Filed: June 14, 2004
    Publication date: November 11, 2004
    Inventors: David S. Jones, Huong-Thu Ton-Nu, Anping Tao, Tong Xu, Jeffrey Robert Hammaker
  • Publication number: 20040092685
    Abstract: The invention relates to an initiator system for radical polymerizations, which is characterized in that a combination of compounds of general formulas (I) and (II) is used, wherein: R′, R″, R′″ and R″″, are selected independently of one another, and represent; a) branched and unbranched C1 to C18 alkyl radicals, C3 to C18 alkenyl radicals, C3 to C18 alkynyl radical; b) C1 to C18 alkyl radicals, C3 to C18 alkenyl radicals, C3 to C18 alkynyl radicals, which are all substituted for at least one OH group or for a halogen atom or for a silyl ether; c) C2-C18 hetero-alkyl radicals having at least one O atom and/or an NR group in the carbon chain, whereby R is selected from one of groups a), b) or d) to g); d) C1-C18 alkyl radicals, C3-C18 alkenyl radicals, C3-C18 alkynyl radical, which are all substituted for at least one ester group, amine group, carbonate group and/or epoxy group and/or for sulfur and/or for sulfur compounds, especially thioether or dithio compounds; e) C3-C12
    Type: Application
    Filed: June 19, 2003
    Publication date: May 13, 2004
    Inventors: Marc Husemann, Stephan Zollner
  • Patent number: 6717012
    Abstract: The invention provides novel adamantane compounds having one of the following formulas: wherein: R1 and R3 are H, OH, alkyl, cycloalkyl, amino or aryl, and can be the same or different; R2 is H, NH2, alkyl, OH, COOH, amino, amide, or carbamate; R4-R8 are H, OH, NH2, alkyl, OH, COOH, ester, amino, amide, or alkyloxy, and can be the same or different; R9-R14 are H, alkyl, or phenyl, and can be the same or different; and wherein when any of R1-R8 is amino, the compounds are the free bases and their acid addition salts. The present invention also relates to compositions and methods for treating and/or preventing neurological and inflammatory disorders in a patient by administering a therapeutically effective amount of the compounds of formula (I), (II) or (III) and a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: April 2, 2002
    Date of Patent: April 6, 2004
    Assignee: NeuroMolecular, Inc.
    Inventors: Yuqiang Wang, James W. Larrick
  • Patent number: 6706923
    Abstract: Perfluoroalkyl-substituted amines, acids, amino acids and thioether acid compounds containing a perfluoroalkyl-iodoalkyl or perfluoroalkyl-alkene group as well as derivatives thereof, are described. They are useful as surfactants in a variety of applications where low surface tensions are required, including coating formulations for glass, wood, metal, cement, paper, textiles, as foam control agents in polyurethane foams and especially in aqueous fire-fighting formulations.
    Type: Grant
    Filed: July 24, 2002
    Date of Patent: March 16, 2004
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Marlon Haniff, Ted Deisenroth, John Jennings, Karl Friedrich Mueller
  • Patent number: 6653414
    Abstract: Disclosed herein is a method for inhibiting the premature polymerization of ethylenically unsaturated monomers comprising adding to said monomers an effective amount of a mixture comprising: A) at least one stable hindered nitroxyl compound having the structural formula: wherein R1 and R4 are independently selected from the group consisting of hydrogen, alkyl, and heteroatom-substituted alkyl and R2 and R3 are independently selected from the group consisting of alkyl and heteroatom-substituted alkyl; and X1 and X2 (1) are independently selected from the group consisting of halogen, cyano, COOR7, —S—COR7, —OCOR7, (wherein R7 is alkyl or aryl), amido, —S—C6H5, carbonyl, alkenyl, or alkyl of 1 to 15 carbon atoms, or (2) taken together, form a ring structure with the nitrogen; and B) at least one inhibitor selected from the group consisting of ortho-quinone, ortho-hydroquinone, para-quinone, para-hydroquinone, and derivatives of the foregoing.
    Type: Grant
    Filed: July 30, 2001
    Date of Patent: November 25, 2003
    Assignee: Uniroyal Chemical Company, Inc.
    Inventors: Brigitte Benage, Brendan J. Geelan, Gerald J. Abruscato, Leo Bonnell
  • Patent number: 6579461
    Abstract: The invention relates to a process for the reprocessing respectively purification of aqueous solutions of a tertiary amine oxide, particularly of process waters, e.g. used precipitation baths, which occur during the production of cellulosic moulded bodies, comprising the separation of turbidifying agents and solid impurities from the solution. The process in accordance with the invention is characterised in that the turbidifying agents and impurities are at least partly separated by means of a flotation process.
    Type: Grant
    Filed: March 13, 2001
    Date of Patent: June 17, 2003
    Assignee: Lenzing Aktiengesellschaft
    Inventors: Johann Männer, Rudolf Emeder, Christian Hager, Franz Nussbaumer, Thomas Endl, Johannes Kneissl
  • Patent number: 6538141
    Abstract: The invention concerns a method for preparing nitroxides, which consists in oxidising, in a two-phase medium, using an aliphatic peroxide, secondary amines with steric hindrance or having a —CH in the nitrogen atom &agr;.
    Type: Grant
    Filed: September 24, 2001
    Date of Patent: March 25, 2003
    Assignee: Atofina
    Inventors: Jean-Philippe Gillet, Olivier Guerret, Jean-Pierre Lascombe
  • Publication number: 20030045574
    Abstract: The invention provides novel adamantane compounds having one of the following formulas: 1
    Type: Application
    Filed: April 2, 2002
    Publication date: March 6, 2003
    Inventors: Yuqiang Wang, James W. Larrick
  • Patent number: 6475419
    Abstract: Methods of preparing cellulose materials, which methods comprise (a) reacting a cellulosic material with a first basic component to form alkli cellulose; (b) reacting the alkali cellulose with carbon disulfide and a second basic component to form a cellulose xanthate solution; and (c) extruding the cellulose xanthate into an aqueous coagulation bath; wherein a reaction product of an epoxide of the general formula (I): wherein R1 represents a linear or branched aliphatic alkyl group having from about 1 to about 22 carbon atoms, and an amine compound of the general formula (II): wherein R2 and R3 each independently represent a substituent selected from the group consisting of —CnH2n—O)m—H, alkyl groups having from about 1 to about 22 carbon atoms, and hydrogen, wherein n represents 2 or 3 and m represents a number of from about 1 to about 20; is present in at least one of the cellulose xanthate solution and the aqueous coagulation bath, are described.
    Type: Grant
    Filed: September 6, 2000
    Date of Patent: November 5, 2002
    Assignee: Cognis Deutschland GmbH
    Inventors: Martin Lagarden, Raymond Mathis, Ursula Kolken
  • Patent number: 6417401
    Abstract: The present invention is related to a series of derivatives of novel ether diamine compounds prepared by the cyanobutylation reaction of an alcohol having 3 to 22 carbon atoms with 2-pentenenitrile to form a branched alkyl ether nitrile. The etheraminonitriles formed by the process are hydrogenated to form alkylether amines. The resulting product can be reacted with 2-pentenenitrile and or acrylonitrile and in a subsequent step, hydrogenated to yield a diamine. Specifically, the present invention deals with two types of tertiary amines one made by the reaction of novel ether diamines compounds with ethylene oxide, propylene oxide or butylene oxide or mixtures thereof, producing alkoxylated tertiary amines and the other made by the reaction of novel ether amine compounds with formaldehyde and hydrogen producing methylated tertiary amines. The invention also disclosed novel amine oxides, and quaternary compounds made from said tertiary amines.
    Type: Grant
    Filed: January 22, 2002
    Date of Patent: July 9, 2002
    Assignee: Nova Molecular Technologies INC
    Inventors: Thomas J. Daly, Michael Clumpner, Anthony J. O'Lenick, Jr.
  • Publication number: 20020040117
    Abstract: For the preparation of a multimodal polymer at least one monomer is subjected to free radical polymerization in the presence of several alkoxyamines comprising the sequence of formula: 1
    Type: Application
    Filed: April 9, 2001
    Publication date: April 4, 2002
    Applicant: ATOFINA
    Inventors: Olivier Guerret, Sophie Robin, Yves Gnanou
  • Publication number: 20020004531
    Abstract: PBN (&agr;-phenyl-tert-butylnitrone), and its derivatives nitrone-based free radical traps, significantly reduce preneoplastic nodule development as well as inhibit hepatocellular carcinoma (HCC) formation at very low levels. The involvement of reactive oxygen species (ROS) in cancer development has been strongly implicated for many years. The involvement of ROS has been strongly implicated in cancer development is a model system where feeding a choline deficiency (CD) diet to rats leads to hepatocellular carcinoma (HCC) development. Administering PBN in the drinking water inhibits HCC formation. Preneoplastic nodule growth in the liver is significantly suppressed by administering PBN, or some ofits natural metabolites, in the diet. The effectiveness of PBN in preventing HCC development in the CD liver model is considered due to its prevention of tumor development after the target cells have already been initiated, i.e.genetically changed into tumor cells.
    Type: Application
    Filed: March 28, 2001
    Publication date: January 10, 2002
    Applicant: OKLAHOMA MEDICAL RESEARCH FOUNDATION
    Inventors: Robert A. Floyd, Yashige Kotake, Kenneth L. Hensley, Dai Nakae
  • Patent number: 6291702
    Abstract: The present invention relates to chromotropic nitrone spin trapping agents, methods of making these agents, compositions comprising same, and methods of their use. In particular, azulenyl nitrones of the present invention are effective agents for trapping free radical species and find use as efficient antioxidants in physicochemical and biological systems. Accordingly, the invention also relates to spin adducts formed from the combination of azulenyl nitrones with free radicals. The compounds of the present invention are readily prepared from available starting materials and find further use in assays and in a number of diagnostic, prophylactic and therapeutic applications, including but not limited to the alleviation, modulation and inhibition of the negative effects of carbon-centered or oxygen-centered radical species and other products of oxidation. Moreover, the combination adducts may be colorimetrically detected and, optionally, isolated and characterized to obtain valuable information (e.g.
    Type: Grant
    Filed: February 8, 2000
    Date of Patent: September 18, 2001
    Assignee: Florida International University
    Inventor: David Alan Becker
  • Patent number: 6197825
    Abstract: The present invention relates to chromotropic nitrone spin trapping agents, methods of making these agents, compositions comprising same, and methods of their use. In particular, azulenyl nitrones of the present invention are effective agents for trapping free radical species and find use as efficient antioxidants in physicochemical and biological systems. Accordingly, the invention also relates to spin adducts formed from the combination of azulenyl nitrones with free radicals. The compounds of the present invention are readily prepared from available starting materials and find further use in assays and in a number of diagnostic, prophylactic and therapeutic applications, including but not limited to the alleviation, modulation and inhibition of the negative effects of carbon-centered or oxygen-centered radical species and other products of oxidation. Moreover, the combination adducts may be calorimetrically detected and, optionally, isolated and characterized to obtain valuable information (e.g.
    Type: Grant
    Filed: May 28, 1998
    Date of Patent: March 6, 2001
    Assignee: Florida International University
    Inventor: David Alan Becker
  • Patent number: 6166255
    Abstract: Exothermic oxidation of tertiary amine with aqueous hydrogen peroxide in an aqueous reaction medium formed or being formed from tertiary amine, aqueous hydrogen peroxide, carbon dioxide, and optionally chelating agent and/or additional water, is initiated at about 15 to about 25.degree. C., and while agitating the reaction mixture, the temperature is allowed to rise adiabatically to a temperature in the range of about 50 to about 100.degree. C. In this way, it is possible to produce tertiary amine oxides with very low levels, if any, of nitrosamine impurity, without addition of metal and/or phosphorus-containing components recommended in the prior art. Even though a substantial portion of the reaction is performed at temperatures in the range of about 50-100.degree. C., nitrosamine content, if any, in the resultant tertiary amine oxide product can be well below 30 ppb, and the free amine content, if any, can be well below 0.3 wt %.
    Type: Grant
    Filed: September 11, 1998
    Date of Patent: December 26, 2000
    Assignee: Albemarle Corporation
    Inventors: Rebecca S. Cochran, Andrea P. Wight, Douglas H. Krzystowczyk, Dustin H. Thomas
  • Patent number: 6147068
    Abstract: A pharmaceutical composition of matter for delivering nitric oxide. The composition is an amine that was reacted with nitric oxide. The composition of matter is lipophilic and insoluble and therefore delivers nitric oxide to the specific area of the body where it is introduced. Also, a method of synthesizing an amine and reacting it with nitric oxide to form the pharmaceutical composition of matter. Finally, a method of using the pharmaceutical composition of matter to deliver nitric oxide to the body.
    Type: Grant
    Filed: September 21, 1998
    Date of Patent: November 14, 2000
    Assignee: The University of Akron
    Inventors: Daniel J. Smith, Dominick Roselle
  • Patent number: 6121490
    Abstract: A process for producing tertiary amine oxide having two methyl or ethyl groups and one long chain primary aliphatic group in a stable, solid form is described. Aqueous 65-90% hydrogen peroxide and tertiary amine having two methyl or ethyl groups and one primary aliphatic hydrocarbyl group of 8-24 carbon atoms are mixed in proportions of ca. 1.1-1.3 moles of hydrogen peroxide per mole of tertiary amine in the presence of carbon dioxide and in the absence of organic solvent. When the conversion of the tertiary amine to tertiary amine oxide in the reaction mass has reached ca. 60-90%, the reaction mass is transferred to a separate vessel and the reaction mass is then allowed to solidify at a temperature of ca. 20-60.degree. C. The process makes possible the production of highly pure solid product without formation of any appreciable amounts of undesirable by-products.
    Type: Grant
    Filed: April 14, 1999
    Date of Patent: September 19, 2000
    Assignee: Albemarle Corporation
    Inventor: Hassan Y. Elnagar
  • Patent number: 6054616
    Abstract: The claimed process consists in treating the tertiary amine oxide with a sulphite or a bleach activator.
    Type: Grant
    Filed: March 26, 1999
    Date of Patent: April 25, 2000
    Assignee: Clariant Finance (BVI) Limited
    Inventors: Cheryl Ann Littau, Graham Cox, Michael Neil Holland
  • Patent number: 6015838
    Abstract: This invention provides aqueous film-forming foamable (AFFF) compositions comprising one or more environmentally-friendly .alpha.-branched fluoroalkylcarbonyl group-containing surfactants.
    Type: Grant
    Filed: November 4, 1996
    Date of Patent: January 18, 2000
    Assignee: 3M Innovative Properties Company
    Inventors: Richard M. Stern, Wei-Qiang Fan
  • Patent number: 6002002
    Abstract: The present invention provides novel hydroxylamine derivatives represented by the general formula: wherein:X is O, --NH, or a group of formula NR', wherein R and R' are independently selected from alkyl, cycloalkyl, phenylalkyl, phenyl optionally substituted with halo, haloalkyl,alkyl, alkoxy or nitro; and a N-containing heterocyclic ring;R.sup.1 is H or alkanoyl,R.sup.2 is H or hydroxy optionally acylated with alkanoyl, andR.sup.3 is a group of the formula --NR.sup.4 R.sup.5 wherein R.sup.4 and R.sup.5 are independently selected fromH, alkyl, and a group of the formula --CO--NH--R wherein R is as defined above, orwherein R.sup.4 and R.sup.5 when taken together form a 5- to 7-membered heterocyclic ring which may optionally contain one additional hetero atom selected from nitrogen, oxygen and sulfur and which is optionally substituted with alkyl or phenylalkyl.
    Type: Grant
    Filed: May 13, 1998
    Date of Patent: December 14, 1999
    Assignee: Biorex Research & Development Co.
    Inventors: Laszlo Urogdi, Ede Marvanyos, Mihaly Barabas, Laszlo Jaszlits, Katalin Biro, Andrea Jednakovits, Erzsebet Radvanyne, Maria Kurthy, Istvanne Udvardy Nagy
  • Patent number: 5773655
    Abstract: The invention is concerned with a process for the purification of an aqueous solution of a tertiary amine-oxide containing impurities partially present in a dissolved and partially in a non-dissolved, colloidal state, and is characterized by a combination of the steps of(A) removing from the aqueous solution substantially all of said impurities present in a non-dissolved, colloidal state and(B) contacting said aqueous solution obtained in step (A) with an ion exchanger.
    Type: Grant
    Filed: April 15, 1997
    Date of Patent: June 30, 1998
    Assignee: Lenzing Aktiengesellschaft
    Inventors: Eduard Mulleder, Bruno Mangeng, Franz Schwenninger, Johann Manner
  • Patent number: 5756000
    Abstract: This invention provides perfluoro(alkoxycycloalkane) carbonyl fluoride compounds wherein, pendant from the fluorinated ring, are from 2 to 5 perfluoroalkoxy groups having from 1 to 4, preferably 1 to 2, carbon atoms with the proviso that when one or more of the perfluoroalkoxy groups contain from 3 to 4 carbon atoms, there are no more than 3 pendant groups.In yet another aspect, this invention provides aqueous film-forming foam (AFFF) compositions comprising one or more perfluoro(alkoxycycloalkane) carbonyl group-containing surfactants and one or more water-soluble fluorine-free surfactants selected from the group consisting of nonionic hydrocarbon-containing surfactants with a hydrophilic-lipophilic balance (HLB) value greater than or equal to about 10 and ionic hydrocarbon-containing surfactants having a carbon chain length containing inclusively from about 6 to about 10 carbon atoms.
    Type: Grant
    Filed: February 6, 1996
    Date of Patent: May 26, 1998
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: John C. Hansen, George G. I. Moore, Stephen D. Polson, Patricia M. Savu, Richard M. Stern