Acyclic Patents (Class 564/30)
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Publication number: 20150136611Abstract: Reaction products of guanidine compounds or salts thereof, polyepoxide compounds and polyhalogen compounds may be used as levelers in metal electroplating baths, such as copper electroplating baths, to provide good throwing power. Such reaction products may plate with good surface properties of the metal deposits and good physical reliability.Type: ApplicationFiled: November 21, 2013Publication date: May 21, 2015Inventors: Julia KOZHUKH, Zuhra I. NIAZIMBETOVA, Maria Anna RZEZNIK
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Patent number: 8410150Abstract: A CPT inhibitor compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof: or a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. A method of treating a subject having cancer comprises administering to the subject a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof.Type: GrantFiled: March 6, 2008Date of Patent: April 2, 2013Assignee: University Health NetworkInventors: Heinz W. Pauls, Peter Brent Sampson, Bryan T. Forrest, Radoslaw Laufer, Yong Liu, Miklos Feher, Yi Yao, Guohua Pan
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Publication number: 20120322877Abstract: The invention provides for novel (bis)urea and (bis)thiourea compounds which are inhibitors of lysine-specific demethylase 1 (LSD1). Such compounds may be used to treat disorders, including cancer.Type: ApplicationFiled: August 18, 2010Publication date: December 20, 2012Inventors: Robert A. Casero, Patrick M. Woster
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Patent number: 8269041Abstract: The present invention relates to salts having thiouronium or uronium cations, to processes for the preparation thereof, and to the use thereof as ionic liquids.Type: GrantFiled: May 28, 2004Date of Patent: September 18, 2012Assignee: Merl Patent GmbHInventors: Nikolai (Myloka) Ignatyev, Urs Welz-Biermann, German Bissky, Helge Willner, Andriy Kucheryna
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Publication number: 20110178212Abstract: The invention relates to a method for producing at least one compound having at least one at least monosubstituted amino group. According to the invention, a starting substance having at least one amino group is reacted with an alcohol in a reaction mixture in the presence of ammonia.Type: ApplicationFiled: March 27, 2009Publication date: July 21, 2011Applicant: BOREALIS AGROLINZ MELAMINE GMBHInventors: Rene Dicke, Andreas Endesfleder, Martin Burger, Christoph Hahn, Clemens Schwarzinger, Wolfgang Fuerst, Harald Schmidt
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Publication number: 20100298340Abstract: This invention relates to novel compounds having the structural formula I below: and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.Type: ApplicationFiled: April 12, 2007Publication date: November 25, 2010Applicants: AstraZeneca AB, Astex Therapeutics Ltd.Inventors: Stefan Berg, Karin Kolmodin
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Publication number: 20100113548Abstract: The present invention relates to antagonists of the human bitter-taste receptors hTAS2R38. The invention also relates to methods for identifying further molecules that suppress hTAS2R38 mediated bitter taste transduction or bitter taste response and uses thereof.Type: ApplicationFiled: April 18, 2008Publication date: May 6, 2010Applicant: DEUTSCHES INSTITUT FUR ERNAHRUNGSFORSCHUNG POTSDAM-REHBRUCKEInventors: Bernd Bufe, Christina Kuhn, Wolfgang Meyerhof
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Patent number: 7326746Abstract: Electron donor compounds, suitable for use as adhesives or as components in adhesives, contain a carbon to carbon double bond attached to an aromatic ring and conjugated with the unsaturation in the aromatic ring.Type: GrantFiled: February 17, 2005Date of Patent: February 5, 2008Inventors: Osama M. Musa, Donald E. Herr, Nikola A. Nikolic
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Patent number: 7323602Abstract: A process for preparing an intermediate compound of formula (II) where n is an integer of from 3 to 14; R1 is haloC1-10alkyl, C1-10alkyl, C2-10alkenyl, C2-10cycloalkyl, carboxyC1-10alkyl, C1-10alkoxycarbonylC1-10alkyl, aryl (such as phenyl), aryl(C1-10)alkyl (such as phenyl(C1-10)alkyl) or di(C1-6alkyl)amino; and R2 is a halo group; the process comprising halogenation of a compound of formula (III) where n and R1 are as defined above. Novel compounds are also described and claimed.Type: GrantFiled: October 3, 2002Date of Patent: January 29, 2008Assignee: AstraZeneca ABInventors: Kenneth Edwin Herbert Warren, Anne Margaret Lamont Kane
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Patent number: 6908957Abstract: Electron donor compounds, suitable for use as adhesives or as components in adhesives, contain a carbon to carbon double bond attached to an aromatic ring and conjugated with the unsaturation in the aromatic ring.Type: GrantFiled: August 3, 2001Date of Patent: June 21, 2005Assignee: National Starch and Chemical Investment Holding CorporationInventors: Osama M. Musa, Donald E. Herr, Nikola A. Nikolic
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Publication number: 20020155505Abstract: The present invention provides novel methods for ligand discovery. The inventive methods rely on a process termed “tethering” where potential ligands are covalently bonded or “tethered” to a target and subsequently identified.Type: ApplicationFiled: April 10, 2002Publication date: October 24, 2002Inventors: Jim Wells, Dan Erlanson, Andrew C. Braisted
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Publication number: 20010053555Abstract: A novel method for generating hydroxylamine, hydroxamic acid, hydroxyurea, and hydroxylsulfonamide compounds is disclosed. The method involves the nucleophilic attack of an alkoxyamine on a suitable solid phase support. Techniques of combinatorial chemistry can then be applied to the immobilized alkoxyamine to generate a diverse set of compounds. Cleavage of the compounds from the support yields a library of hydroxylamine or hydroxylamine derivative compounds, which can be screened for biological activity (e.g., inhibition of metalloproteases).Type: ApplicationFiled: October 27, 1997Publication date: December 20, 2001Inventors: DINESH V. PATEL, KHEHYONG NGU
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Patent number: 6187726Abstract: Compounds and lubricant compositions are disclosed that comprise a substituted linear thiourea of the structure wherein R1, R2, and R4 are independently selected from the group consisting of alkyl, alkenyl, aryl, alkaryl, aralkyl, and hydrogen; R3 is selected from the group consisting of alkyl, alkenyl, and combinations thereof; X is selected from the group consisting of (i) methylene, if, and only if, R3 is alkenyl, (ii) oxygen, and (iii) sulfur; and A is selected from the group consisting of alkylene and aryl.Type: GrantFiled: November 12, 1999Date of Patent: February 13, 2001Assignee: CK Witco CorporationInventors: Theodore E. Nalesnik, Franklin H. Barrows
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Patent number: 5958184Abstract: A process for producing a thiourea dioxide fluid by mixing thiourea and a peroxide, or thiourea, a peroxide and a reaction catalyst, or thiourea, a peroxide, a reaction catalyst and a chelating agent, in the absence or presence of pulp and a process for bleaching pulp by the use of the thiourea dioxide fluid produced by the above process economically advantageously with a small chemicals loss and by small consumption of energy.Type: GrantFiled: January 29, 1998Date of Patent: September 28, 1999Assignee: Mitsubishi Gas Chemical Company Inc.Inventors: Toshiaki Kanada, Seikyu Jinnouchi, Masafumi Shimpo, Tetsuo Koshitsuka, Akiko Kimura
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Patent number: 5620831Abstract: Disclosed are novel cyanoguanidine derivatives which are usable as an epoxy resin curing agent and are represented by the following general formula (1). A thermosetting resin composition and a photocurable and thermosetting resin composition containing the following cyanoguanidine derivatives and other derivatives as the epoxy resin curing agent are also disclosed. ##STR1## wherein R.sup.1 represents a substituent selected from the group consisting of the following substituents (a) through (k).Type: GrantFiled: March 28, 1995Date of Patent: April 15, 1997Assignee: Taiyo Ink Manufacturing Co., Ltd.Inventor: Osamu Kawana
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Patent number: 5107021Abstract: The invention relates to polyfluoroalkyl nitrogen compounds of general formula:R.sub.F --(CH.sub.2).sub.2 --Xin which X denotes an isothiocynate --N.dbd.C.dbd.S, carbodiimide --N.dbd.C.dbd.N(CH.sub.2).sub.2 --R'.sub.F or thiourea --NH--CS--A group, A denoting an optionally substituted amino group, and each of the symbols R.sub.F and R'.sub.F denotes a perfluoroalkyl radical.These compounds, prepared from the corresponding azides R.sub.F (CH.sub.2).sub.2 N.sub.3 or amines R.sub.F (CH.sub.2).sub.2 NH.sub.2, can be used as surface-active agents or precursors of such agents.Type: GrantFiled: April 12, 1991Date of Patent: April 21, 1992Assignee: Societe ATOCHEMInventors: Eric Bollens, Francois Szonyi, Aime Cambon
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Patent number: 5055544Abstract: This invention relates to novel polymeric polyamines containing internal urea, biuret, thiourea, dithiobiuret, amide, and/or thioamide moieties, and to polymers prepared therefrom. This invention also relates to novel isocyanate-functional prepolymers containing urea, biuret, thiourea, dithiobiuret, amide, and/or thioamide moieties and to polymers prepared therefrom.Type: GrantFiled: February 27, 1990Date of Patent: October 8, 1991Assignee: The Dow Chemical CompanyInventors: Robert F. Harris, Michael D. Joseph
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Patent number: 5026910Abstract: The invention relates to polyfluoroaklyl nitrogen compounds of general formula:R.sub.F --(CH.sub.2).sub.2 --Xin which X denotes an isothiocyanate --N.dbd.C.dbd.S, carbodiimide --N.dbd.C.dbd.N(CH.sub.2).sub.2 --R'.sub.F or thiourea --NH--CS--A group, A denoting an optionally substituted amino group, and each of the symbols R.sub.F and R'.sub.F denotes a perfluoroalkyl radical.these compounds, prepared from the corresponding axides R.sub.F (CH.sub.2).sub.2 N.sub.3 or amines R.sub.F(CH.sub.2).sub.2 NH.sub.2, can be used as surface-active agents or precursors of such agents.Type: GrantFiled: May 22, 1990Date of Patent: June 25, 1991Assignee: Societe AtochemInventors: Eric Bollens, Francois Szonyi, Aime Cambon
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Patent number: 4997981Abstract: An amine substituion process for 2-(1-pentyl-3-guanidino)-4-(2-methyl-4-imidazolyl)thiazole, for precursor N-(pentylamidino)thiourea, and for analogs thereof of said compounds.Type: GrantFiled: April 20, 1989Date of Patent: March 5, 1991Assignee: Pfizer Inc.Inventors: Paul D. Hill, William M. Snyder, Stanley W. Walinsky
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Patent number: 4988688Abstract: 4-(N-Substituted amino)-2-butynyl-1-ureas and thioureas and derivatives thereof are described, as well as methods for the preparation and pharmaceutical compositions of same, which are useful as centrally acting muscarinic agents and are useful as analgesic agents for the treatment of pain, as sleep aids and as agents for treating the symptoms of senile dementia, Alzheimer's disease, Huntington's chorea, tardive dyskinesia, hyperkinesia, mania, or similar conditions of cerebral insufficiency characterized by decreased cerebral acetylcholine production or release.Type: GrantFiled: August 2, 1989Date of Patent: January 29, 1991Assignee: Warner-Lambert CompanyInventors: Jeffrey A. Kester, Walter H. Moos, Anthony J. Thomas
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Patent number: 4977170Abstract: Novel isoprenoidamine compounds (I) which show antiulcer activity are provided.Type: GrantFiled: May 3, 1989Date of Patent: December 11, 1990Assignee: Shionogi & Co., Ltd.Inventors: Saichi Matsumoto, Masami Doteuchi, Takuji Mizui, Kentaro Hirai
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Patent number: 4943661Abstract: An amine-substituted thiourea dioxide is obtained by reacting thiourea dioxide and an aliphatic or aromatic primary amine in a neutral or acidic pH range.Type: GrantFiled: March 14, 1989Date of Patent: July 24, 1990Assignee: Tokai Denka Kogyo Kabushiki KaishaInventors: Hirohisa Nitoh, Osami Ohura, Morio Suzuki
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Patent number: 4760178Abstract: A process for producing compounds containing hydroxy alkyl amide groups by the reaction of a bicyclic amide acetal with a member selected from the group consisting of urea, biuret, thiourea, thiobiuret, alkyl substituted ureas, aryl substituted ureas, alkyl substituted thioureas, aryl substituted thioureas, alkylene ether ureas, arylene ether ureas, alkylene ether tioureas and arylene ether thioureas is disclosed.Type: GrantFiled: April 11, 1986Date of Patent: July 26, 1988Assignee: Ashland Oil, Inc.Inventor: Anil B. Goel
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Patent number: 4568694Abstract: Cystamine derivatives of the formula: ##STR1## [wherein n represents 2 or 3, R.sup.1 and R.sup.2 each represents a hydrogen atom, or an alkyl group optionally substituted by a hydroxy, amino, alkylamino or dialkylamino group, or represents a cycloalkyl or aryl group, and X.sup.1 represents a group selected from the formulae .dbd.N--CN, .dbd.N--NO.sub.2, .dbd.N--COR.sup.3, .dbd.N--COOR.sup.3, .dbd.N--NH--CONH.sub.2, .dbd.N--SO.sub.2 R.sup.3, .dbd.CH--NO.sub.2, .dbd.CH--SO.sub.2 R.sup.3, .dbd.C(CN).sub.2, .dbd.C(CN)COOR.sup.3 and .dbd.C(CN)CONH.sub.2 (wherein R.sup.3 represents an alkyl or aryl group), or R.sup.1 represents a hydrogen atom, R.sup.2 represents an alkyl group optionally substituted by a hydroxy, amino, alkylamino or dialkylamino group, or represents a cycloalkyl or aryl group and X.sup.1 represents an oxygen or sulphur atom] have been found to be useful in the promotion of the growth of non-human animals including birds.Type: GrantFiled: June 15, 1983Date of Patent: February 4, 1986Assignee: May & Baker LimitedInventors: Richard M. Griffin, Malcolm N. Palfreyman
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Patent number: 4554354Abstract: The invention disclosed in this application is the use of novel silanes in curable coatings to allow tinting or dyeing of the coatings after they are cured on certain substrates.An example of one such useful silane is ##STR1## The silanes and the curable coatings are also useful as antistat and antifog coatings.Type: GrantFiled: December 14, 1984Date of Patent: November 19, 1985Assignee: Dow Corning CorporationInventors: Loren A. Haluska, Marcelle G. Molzahn
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Patent number: 4492658Abstract: This invention relates to Thioureylene prepared by reacting an oxyalkylated polyamine with thiourea and to uses of such Thioureylene for example in removing oils, solids, and combinations thereof from aqueous systems, etc.Type: GrantFiled: July 21, 1980Date of Patent: January 8, 1985Assignee: Petrolite CorporationInventor: Thomas J. Bellos
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Patent number: 4324910Abstract: A substituted urea compound containing at least one 2,2,2-trichloro-1-hydroxyethyl group is provided which is useful as a flame retardant for polymers such as polyurethane.Type: GrantFiled: February 20, 1981Date of Patent: April 13, 1982Assignee: Pennwalt CorporationInventors: Stanley R. Sandler, Mabel M. Chen
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Patent number: 4314067Abstract: Polymerizable monomeric compounds corresponding to the general formula ##STR1## wherein R is H or CH.sub.3, U designates a cyclic or acyclic ureido or thioureido group and L designates a selected linking structure. The linking structure L may contain one or more oxy (ether), amino, amido, or carbonyl groups provided that any carbonyl group (CO) present is not directly attached to U or to an ethylenic carbon atom nor is such ethylenic carbon atom directly attached to a nitrogen atom.Type: GrantFiled: March 6, 1978Date of Patent: February 2, 1982Assignee: Air Products and Chemicals, Inc.Inventors: Frederick L. Herman, Dale D. Dixon
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Patent number: 4293454Abstract: A flame retardant composition is prepared by reacting chloral with a nitrogen compound having the formula: ##STR1## wherein: (a) X= ##STR2## or, --SO.sub.2 --; (b) Z is selected from O or S;(c) R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are selected from the group consisting of H, alkyl of 1 to 6 carbons, and substituted or unsubstituted hydroxyalkyl of 2 to 4 carbons and mixtures thereof in a temperature range of 25.degree. to 100.degree. C., in the absence of a solvent and in an apparatus that provides efficient mixing. These compositions are useful for preparing flame retardant polyurethane foams.Type: GrantFiled: February 4, 1980Date of Patent: October 6, 1981Assignee: Pennwalt CorporationInventors: Harold G. Monsimer, Stanley R. Sandler
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Patent number: 4264614Abstract: The invention provides compounds of general formula ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof, in whichY and Z, which may be the same or different, each represent oxygen, sulphur, =CHNO.sub.2 or =NR.sub.3 where R.sub.3 is hydrogen, nitro, cyano, lower alkyl, aryl, alkylsulphonyl or arylsulphonyl;p has a value from 2 to 12;R.sub.1 represents ##STR2## in which R.sub.4 and R.sub.5 which may be the same or different, each represent hydrogen, lower alkyl, cycloalkyl, lower alkenyl, aralkyl or lower alkyl interrupted by an oxygen atom or a group >N-R.sub.6 in which R.sub.6 represents hydrogen or lower alkyl, or R.sub.4 and R.sub.5 together with the nitrogen atom to which they are attached form a 5 to 7-membered saturated heterocyclic ring which may contain an additional oxygen atom or the group >NR.sub.Type: GrantFiled: November 16, 1979Date of Patent: April 28, 1981Assignee: Glaxo Group LimitedInventors: John W. Clitherow, Barry J. Price, John Bradshaw