Alicyclic Ring And Plural Amino Nitrogens Containing Patents (Class 564/461)
  • Patent number: 9000219
    Abstract: A method for treating an isocyanate residue, which comprises carrying out a thermal decomposition reaction of a carbamate that is produced by the reaction among an amine, urea and/or an N-unsubstituted carbamic acid ester and an alcohol to produce a decomposition solution, separating an isocyanate and the alcohol from the decomposition solution to produce the isocyanate residue, and bringing the isocyanate residue into contact with high-pressure/high-temperature water to decompose the isocyanate residue into an amine; and a method for treating a carbonate, which comprises bringing the carbonate into contact with high-pressure/high-temperature water to decompose the carbonate into an alcohol.
    Type: Grant
    Filed: December 14, 2010
    Date of Patent: April 7, 2015
    Assignee: Mitsui Chemicals, Inc.
    Inventors: Yoshiki Shimokawatoko, Koichi Murayama, Hiroshi Takeuchi, Takashi Kanno, Masaaki Sasaki, Kazuhiko Okubo
  • Publication number: 20150025026
    Abstract: Campylobacter are the commonest reported bacterial causes of gastroenteritis in the UK and industrialized worlds. This invention relates to a method of preventing or reducing the colonisation of the gastrointestinal tract of an animal with Campylobacter. Accordingly, the present invention provides a method for disinfection of an animal comprising administering to said animal at least one compound that binds to MOMP or FlaA of Campylobacter in an effective amount to reduce the number of Campylobacter present in the gastrointestinal tract of said animal. The present invention also provides a method of preventing or reducing transmission of Campylobacter from one animal to another.
    Type: Application
    Filed: February 15, 2013
    Publication date: January 22, 2015
    Inventors: Jafar Mahdavi, Dlawer Ala'Aldeen
  • Patent number: 8933225
    Abstract: Disclosed are processes and synthetic intermediates for the synthesis of compounds of formula (V) wherein the variables have the definitions contained herein. Such compounds are E1 activating enzyme inhibitors, and are useful for the treatment of disorders of cell proliferation, particularly cancer, and other disorders associated with E1 activity.
    Type: Grant
    Filed: August 1, 2008
    Date of Patent: January 13, 2015
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Ian Armitage, Eric L. Elliott, Marianne Langston, Steven P. Langston, Quentin J. McCubbin, Hirotake Mizutani, Matthew Stirling, Lei Zhu
  • Patent number: 8927756
    Abstract: The present invention relates to a method of producing a carbamate compound, comprising reacting a fluorine-containing carbonic diester compound represented by formula (1) and a non-aromatic diamine compound represented by formula (2) without using a catalyst, to thereby produce a carbamate compound represented by formula (3), and a method of producing an isocyanate compound represented by formula (20) from the carbamate compound without using a catalyst, wherein R represents a fluorine-containing monovalent aliphatic hydrocarbon group, and A represents a divalent aliphatic hydrocarbon group, a divalent alicyclic hydrocarbon group or a divalent aromatic-aliphatic hydrocarbon group.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: January 6, 2015
    Assignee: Asahi Glass Company, Limited
    Inventors: Takashi Okazoe, Yuko Nagasaki, Hidekazu Okamoto
  • Patent number: 8884059
    Abstract: The present invention is directed towards an electrocoating composition comprising a cyclic guanidine.
    Type: Grant
    Filed: September 17, 2010
    Date of Patent: November 11, 2014
    Assignee: PPG Industries Ohio, Inc.
    Inventors: Steven R. Zawacky, Thomas C. Moriarity, Donald W. Boyd, Geoffrey R. Webster, Joseph Lucas, Alan J. Kaylo, Chester J. Szymanski, Venkatachalam Eswarakrishnan
  • Patent number: 8877976
    Abstract: The invention relates to an improved process for preparing 3-aminomethyl-3,5,5-trimethylcyclohexylamine, referred to hereinafter as isophoronediamine or IPDA for short, by means of catalytic hydrogenation and/or catalytic reductive amination (also referred to as aminating hydrogenation) of 3-cyano-3,5,5-trimethylcyclohexanone, also called isophoronenitrile or IPN for short hereinafter.
    Type: Grant
    Filed: November 17, 2011
    Date of Patent: November 4, 2014
    Assignee: Evonik Degussa GmbH
    Inventors: Christian Lettmann, Guido Streukens, Matthias Orschel, Gerda Grund
  • Patent number: 8841485
    Abstract: According to the present invention, a liquid phenol resin that has excellent characteristics of a phenol resin, such as thermal resistance and hardenability, and can produce a molded product having excellent flexibility, and a method of preparing the resin are provided. The present invention relates to a liquid phenol resin obtained by reacting (A) oils and (B) phenols with (C) a secondary and/or a tertiary alkylamine compound, wherein a nitrogen content based on the whole liquid phenol resin is 3% by weight to 30% by weight, and (A):(B)=10:90 to 90:10.
    Type: Grant
    Filed: July 22, 2011
    Date of Patent: September 23, 2014
    Assignee: Sumitomo Bakelite Co., Ltd.
    Inventor: Yuji Suzuki
  • Publication number: 20140142341
    Abstract: Provided is a 3-aminomethyl-3,5,5-trimethylcyclohexylamine preparation method. A feeding flow of 3-cyano-3,5,5-trimethylcyclohexylimine is reacted with NH3 and hydrogen in the presence of a hydrogenation catalyst; the method is characterized by: firstly adding a basic compound to the feeding flow of 3-cyano-3,5,5-trimethylcyclohexylimine, and then after a portion of 3-cyano-3,5,5-trimethylcyclohexylimine has reacted, adding an acidic compound to reaction materials for further hydrogenation reaction to prepare the product. The method ensures that the aminonitrile content in the product is low, thus effectively reducing the duration of the reaction and greatly reducing the consumption of the catalyst during the hydrogenation reaction process.
    Type: Application
    Filed: September 6, 2011
    Publication date: May 22, 2014
    Applicants: Wanhua Chemical (Ningbo) Co., Ltd., WANHUA CHEMICAL GROUP CO., LTD.
    Inventors: Changsheng Chen, Yuan Li, Wenjuan Zhao, Hongyin Cui, Weiqi Hua
  • Patent number: 8686189
    Abstract: The invention is directed to a process for producing intermediates of a compound which exhibits an activated blood coagulation factor Xa inhibitory action and which is a useful preventive and a therapeutic agent for thrombotic diseases. The intermediate production process is represented by the following reaction scheme.
    Type: Grant
    Filed: September 15, 2006
    Date of Patent: April 1, 2014
    Assignee: Daiichi Sankyo Company, Limited
    Inventors: Koji Sato, Kotaro Kawanami, Tsutomu Yagi
  • Publication number: 20130343974
    Abstract: An acid gas absorbent comprising at least one type of diamine compound represented by the following general formula (1), R1R2N—(CHR3)n—CH2—NR4R5??(1), where R1, R2, R4 and R5 represent any of: a cyclic alkyl group having carbon number from 3 to 6; an alkyl group having carbon number from 1 to 4; a hydroxyalkyl group; and a hydrogen atom, R3 represents any of: the hydrogen atom; a methyl group; and an ethyl group, “n” represents an integer number of 1 or 2, at least one of two amino groups is a secondary amino group, both of the two amino groups are groups other than a primary amino group.
    Type: Application
    Filed: June 20, 2013
    Publication date: December 26, 2013
    Inventors: Shinji MURAI, Yukishige MAEZAWA, Yasuhiro KATO, Takehiko MURAMATSU, Masatoshi HODOTSUKA, Satoshi SAITO
  • Patent number: 8362164
    Abstract: The embodiments of the invention relate to a multifunctional lithiated amine-containing compound comprising at least two molecules of lithiated amine in a molecule of the compound. In one embodiment, the compound has a formula where x is an integer of 1 or more, Q is (a) an element selected from the group consisting of O, S, N, P and Si or (b) an alkylene group having from 1 to 20 methylene groups, and R1 and R2 are the same or different and are selected from the group consisting of alkyls, cycloalkyls and aralkyls containing from 1 to 20 carbon atoms. In another embodiment, the compound comprises cyclic lithio amines and has a formula: where x is 1 or more, R3, R4 and R5 are the same or different and represent alkylene groups containing from 3 to 20 carbon atoms.
    Type: Grant
    Filed: October 12, 2011
    Date of Patent: January 29, 2013
    Assignee: Bridgestone Corporation
    Inventor: Yan Yan-Yong
  • Publication number: 20120207927
    Abstract: Disclosed are hafnium- and zirconium-containing precursors and methods of providing the same. The disclosed precursors include a ligand and at least one aliphatic group as substituent selected to have greater degrees of freedom than the usual substituents. The disclosed precursors may be used to deposit hafnium- or zirconium-containing layers using vapor deposition methods such as chemical vapor deposition or atomic layer deposition.
    Type: Application
    Filed: August 13, 2010
    Publication date: August 16, 2012
    Inventors: Christian Dussarrat, Vincent M. Omarjee, Venkateswara R. Pallem
  • Patent number: 8212078
    Abstract: This invention provides aromatic diimines where the diimines have imino groups with at least two carbon atoms, and either are in the form of one benzene ring having two imino groups on the ring, which imino groups are meta or para relative to each other, and in which each position ortho to an imino group bears a hydrocarbyl group, or are in the form of two benzene rings connected by an alkylene bridge and having one imino group on each ring, and in which each position ortho to an imino group bears a hydrocarbyl group.
    Type: Grant
    Filed: December 30, 2005
    Date of Patent: July 3, 2012
    Assignee: Albemarle Corporation
    Inventors: John Y. Lee, Paul L. Wiggins, Judit Orgad, Mahmood Sabahi, Vernon O. Brandt, David W. Owens
  • Publication number: 20120116099
    Abstract: The present invention relates to a method of continuously conveying a liquid which is used as starting material in a chemical reaction by means of a displacement pump having physically separate forward-transport valves and a liquid-filled bidirectional flow line between displacement pump and forward-transport valves, wherein an auxiliary liquid which is a product or a starting material of the chemical reaction and has a melting point which is below the melting point or below the saturation temperature of the liquid to be conveyed is present in the bidirectional flow line. The present invention additionally provides for the use of a product formed by hydrogenation of an aromatic compound as auxiliary liquid for conveying an aromatic compound and also the use of an alcohol or an ester derived from alcohol and carboxylic acid as auxiliary liquid for conveying carboxylic acids or carboxylic acid derivatives.
    Type: Application
    Filed: July 6, 2010
    Publication date: May 10, 2012
    Applicant: BASF SE
    Inventors: Joachim Pfeffinger, Willi Gilcher, Juergen Morell
  • Publication number: 20120116123
    Abstract: The instant invention provides a process for separating one or more aliphatic diamines from reductive amination reaction solvents and impurities, and aliphatic diamines obtained via such a process. The process for separating one or more aliphatic diamines from reductive amination reaction solvents and impurities according to the instant invention comprises the steps of: (1) feeding one or more cycloaliphatic cyanoaldehydes, hydrogen, ammonia, and optionally one or more solvents into a continuous reductive amination reactor system; (2) contacting said one or more cycloaliphatic cyanoaldehydes, hydrogen, and ammonia with each other in the presence of one or more heterogeneous metal based catalyst systems at a temperature in the range of from 80° C. to about 160° C.
    Type: Application
    Filed: July 30, 2010
    Publication date: May 10, 2012
    Applicant: DOW GLOBAL TECHNOLOGIES LLC
    Inventors: Stacie Santhany, Patrick Ho Sing Au-Yeung, Gerald W. Dare, Shawn D. Feist, Barry B. Fish, Daniel A. Hickman, David Jean, Erich J. Molitor, Abraham D. Schuitman, Todd William Toyzan
  • Publication number: 20110313186
    Abstract: The present invention relates to catalysts and processes for preparation thereof, said catalysts being obtainable by contacting a monolithic catalyst support with a suspension which comprises one or more insoluble or sparingly soluble compounds of the elements selected from the group of the elements cobalt, nickel and copper. The invention further relates to the use of the inventive catalyst in a process for hydrogenating organic substances, especially for hydrogenating nitriles, and to a process for hydrogenating organic compounds, which comprises using an inventive catalyst in the process.
    Type: Application
    Filed: February 1, 2010
    Publication date: December 22, 2011
    Applicant: BASF SE
    Inventors: Christof Wilhelm Wigbers, Jochen Steiner, Martin Ernst, Bram Willem Hoffer, Ekkehard Schwab, Johann-Peter Melder
  • Patent number: 8076518
    Abstract: This invention provides chain extender compositions. These compositions comprise (i) an aliphatic secondary diamine, and (ii) a component selected from the group consisting of: (a) a cycloaliphatic primary diamine; (b) an aliphatic secondary diamine; (c) an aliphatic secondary diamine and an aliphatic primary diamine; (d) an aliphatic diimine; and (e) a combination of any two or more of (a) through (d), with the proviso that when (ii) is (a), (i) is a noncyclic aliphatic secondary diamine. Processes for producing polyurethanes, polyureas, and polyurea-urethanes are also provided.
    Type: Grant
    Filed: September 25, 2006
    Date of Patent: December 13, 2011
    Assignee: Albemarle Corporation
    Inventors: Paul L. Wiggins, John Y. Lee, Judit Orgad, David W. Owens
  • Publication number: 20110293703
    Abstract: Aminoalcohol lipidoids are prepared by reacting an amine with an epoxide-terminated compound are described. Methods of preparing aminoalcohol lipidoids from commercially available starting materials are also provided. Aminoalcohol lipidoids may be prepared from racemic or stereochemically pure epoxides. Aminoalcohol lipidoids or salts forms thereof are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these aminoalcohol lipidoid compounds, they are particularly suited for the delivery of polynucleotides. Complexes, micelles, liposomes or particles containing the inventive lipidoids and polynucleotide have been prepared. The inventive lipidoids may also be used in preparing microparticles for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
    Type: Application
    Filed: November 6, 2009
    Publication date: December 1, 2011
    Applicant: Massachusetts Institute of Technology
    Inventors: Kerry Peter Mahon, Kevin Thomas Love, Christopher G. Levins, Kathryn Ann Whitehead, Robert S. Langer, Daniel Griffith Anderson
  • Patent number: 8058475
    Abstract: Novel cyclohexylmethyl compounds corresponding to formula I wherein R1, R2, R3, R4 and R5, have the meanings given in the description. Pharmaceutical formulations containing these compounds, as well as a processes for preparing these compounds and related methods of treatment are also provided.
    Type: Grant
    Filed: June 20, 2008
    Date of Patent: November 15, 2011
    Assignee: Gruenenthal GmbH
    Inventors: Stefan Oberboersch, Beatrix Merla, Bernd Sundermann, Werner Englberger, Hagen-Heinrich Hennies, Achim Kless, Petra Bloms-Funke, Babette-Yvonne Koegel, Heinze Graubaum
  • Publication number: 20110117591
    Abstract: Chemical stain compounds containing a fluorophore and a reducible quenching unit are disclosed. The reducible quenching unit quenches the fluorophore while in its oxidized state. Upon reduction, the quenching properties of the quenching unit are diminished or eliminated. The chemical compounds can be used in a variety of applications, including the detection of bacterial cells, monitoring the electron transport chain function of bacterial cells, monitoring the oxidation state of non-biological systems, and assaying the effectiveness of antibacterial or antimicrobial agents.
    Type: Application
    Filed: October 20, 2010
    Publication date: May 19, 2011
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Ching-Ying CHEUNG, Diane R. Gray, Stephen T. Yue
  • Patent number: 7939589
    Abstract: Provided are polyhydroxy-diamine compounds for use as neutralizing agents for paints and coatings. The compounds are of the formula (I): wherein R1 and R2 are as defined herein.
    Type: Grant
    Filed: June 17, 2010
    Date of Patent: May 10, 2011
    Assignee: Angus Chemical Company
    Inventors: Raymond J. Swedo, Esin Busche, John W. Quinn
  • Publication number: 20110092601
    Abstract: Polyamine, polyamine/guanidino, and polyamine/biguanide compounds bearing allene, propargyl, cyclopropyl, and other reactive moieties are disclosed. The compounds are useful as irreversible inhibitors of the enzyme lysine-specific demethylase-1 and for the treatment of cancer.
    Type: Application
    Filed: April 14, 2008
    Publication date: April 21, 2011
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Patrick M. Woster, Robert A. Casero
  • Publication number: 20110065944
    Abstract: A process for producing a fullerene derivative. The process comprises reacting a fullerene compound with a primary amine in the presence of a peroxide.
    Type: Application
    Filed: October 22, 2008
    Publication date: March 17, 2011
    Applicant: Luna Innovations Incorporated`
    Inventor: Darren K. Macfarland
  • Patent number: 7875253
    Abstract: An object of the invention is to provide a decomposing system for polyisocyanate residues that is capable of suppressing reaction of polyisocyanate residues with high temperature and high pressure water to allow smooth start-up of the operation, and a start-up method for the decomposing system for the polyisocyanate residues. The decomposing system is used for hydrolyzing the polyisocyanate residues to polyamine using high temperature and high pressure water, comprising a hydrolyzer, a water feed pipe connected to the hydrolyzer, a residual feed pipe connected to the water feed pipe, a solvent feed line for filling an organic solvent in a solvent filling portion of the residual feed pipe, and a solvent draining line. Upon start-up of the operation, the organic solvent is previously filled in the solvent filling portion via the solvent feed line and the solvent draining line, first, and then, the high temperature and high pressure water is fed from the water feed pipe to the hydrolyzer.
    Type: Grant
    Filed: July 12, 2006
    Date of Patent: January 25, 2011
    Assignee: Mitsui Chemicals, Inc.
    Inventors: Tadashi Yoshida, Yasumichi Ooto, Akio Saito
  • Publication number: 20100326320
    Abstract: Provided are polyhydroxy-diamine compounds for use as neutralizing agents for paints and coatings. The compounds are of the formula (I): wherein R1 and R2 are as defined herein.
    Type: Application
    Filed: June 17, 2010
    Publication date: December 30, 2010
    Inventors: Raymond J. Swedo, Esin G. Busche, John W. Quinn
  • Patent number: 7767858
    Abstract: This invention provides aromatic diimines which have imino hydrocarbylidene groups with at least two carbon atoms, and aromatic secondary diamines which have amino hydrocarbyl groups with at least two carbon atoms. Both the aromatic diimines and the aromatic secondary diamines either are in the form of one phenyl ring, or are in the form of two phenyl rings connected by an alkylene bridge; each position ortho to an imino group or an amino group bears a hydrocarbyl group. When in the form of one phenyl ring, there are two imino groups on the ring or two amino groups on the ring; the imino groups or amino groups are meta or para relative to each other. When in the form of two phenyl rings connected by an alkylene bridge, there is either one imino group or one amino group on each phenyl ring. Also provided are processes for forming diimines and secondary diamines.
    Type: Grant
    Filed: September 14, 2007
    Date of Patent: August 3, 2010
    Assignee: Albemarle Corporation
    Inventors: Paul L. Wiggins, Judit Orgad, John Y. Lee, Mahmood Sabahi
  • Publication number: 20100125152
    Abstract: Disclosed is a process for the preparation of 1,2-cycloaliphatic diamines from 1,2-aromatic diamines. In one embodiment, the process provides a method for making 1,2-diaminocyclohexane by the reaction of 1,2-phenylenediamine contained in a polar, protic solvent with hydrogen in the presence of a supported rhodium catalyst, ammonia, and a trialkylamine, and having enhanced overall conversion and selectivity.
    Type: Application
    Filed: November 4, 2009
    Publication date: May 20, 2010
    Applicant: INVISTA NORTH AMERICA S.A.R.L
    Inventor: RONALD L. AMEY
  • Publication number: 20090275664
    Abstract: Peptide conjugates in which cytocidal and cytostatic agents, such as polyamine analogs or naphthoquinones, are conjugated to a polypeptide recognized and cleaved by enzymes such as prostate-specific antigen (PSA) and cathepsin B are provided, as well as compositions comprising these conjugates. Methods of using these conjugates in the treatment of prostate diseases are also provided.
    Type: Application
    Filed: July 15, 2009
    Publication date: November 5, 2009
    Inventors: Benjamin FRYDMAN, Laurence J. Maron, Linda Clifford
  • Publication number: 20090030235
    Abstract: The present invention relates to a method for fractionating stereoisomeric compounds which have at least one alcohol and/or amino group.
    Type: Application
    Filed: September 29, 2006
    Publication date: January 29, 2009
    Applicant: BASF SE
    Inventors: Christoph Jakel, Rocco Paciello, Nawid Kashani-Shirazi, Gerd Kaibel
  • Patent number: 7453011
    Abstract: Conformationally restricted polyamine compounds useful in treatment of cancer and other diseases marked by abnormal cell proliferation are disclosed. Improved methods of synthesizing such compounds are also disclosed. In one method of the invention, a carbene-bearing or carbene equivalent-bearing compound is reacted with the double bond of an alkene compound to form a cyclopropyl ring as the first step in the synthesis.
    Type: Grant
    Filed: June 4, 2007
    Date of Patent: November 18, 2008
    Assignee: Progen Pharmaceuticals, Inc.
    Inventors: Linda Clifford, legal representative, Aldonia L. Valasinas, Andrei V. Blokhin, Aparajita Sarkar, Hirak S. Basu, Venodhar K. Reddy, Laurence J. Marton, Yu Wang, Benjamin Frydman
  • Publication number: 20080269525
    Abstract: The invention provides for stable and isolable cyclopropenylidenes of Formula I and stable and isolable cyclopropenylidene-metal complexes of Formula II, and methods of making thereof.
    Type: Application
    Filed: April 10, 2008
    Publication date: October 30, 2008
    Applicant: The Regents of the University of California
    Inventors: Guy Bertrand, Yves Canac, Vincent Lavallo, Bruno Donnadieu
  • Patent number: 7432399
    Abstract: A polyol monomer comprising the formula: R1 and R3 are —H, aliphatic, aromatic, or ether; R2 is aliphatic, aromatic, ester, ether, or acrylic, and R1 contains a hydroxyl group, R3 contains a hydroxyl group, R2 contains —O—CH2—CH(OH)—, or any combination thereof. The polyol monomer may be made by reacting an epoxy and an amine. Either the epoxy contains more than one epoxide groups, the amine contains a hydroxyl group, or both. A thermoset made by reacting the polyol monomer with a polyisocyanate.
    Type: Grant
    Filed: November 2, 2004
    Date of Patent: October 7, 2008
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Jozef Verborgt, Arthur Anthony Webb
  • Patent number: 7414040
    Abstract: Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.
    Type: Grant
    Filed: June 6, 2003
    Date of Patent: August 19, 2008
    Assignee: SmithKline Beecham Corporation
    Inventor: Dirk A. Heerding
  • Patent number: 7388112
    Abstract: The synthesis and use of a novel class of tumor necrosis factor (TNF?) inhibitors and immunomodulators are provided. Examples are those having the structures: wherein a, b and c are integers from 0 to 12, X equals NH or CHNH2, R1 and R2 each is a hydrogen or a C1 to C20 aliphatic; aliphatic amine; an alicyclic; aromatic; heterocycle; and halogenated forms thereof; and wherein, a, b and c are integers from 0 to 12; R1, R2, R3, and R4 each is a hydrogen or a C1 to C20; aliphatic amine; an alicyclic; aromatic; a heterocycle; and halogenated forms thereof.
    Type: Grant
    Filed: July 1, 2005
    Date of Patent: June 17, 2008
    Assignee: MediQuest Therapeutics, Inc.
    Inventors: Mark R. Burns, Maralee McVean, Kevin Kennedy, Arthur Yeung, Bruce H. Devens
  • Patent number: 7309799
    Abstract: One aspect of the present invention relates to methods for synthesizing milnacipran or congeners thereof. Another aspect of the present invention relates to asymmetric methods for synthesizing enantiomerically enriched milnacipran or congeners thereof. The present invention also relates to methods for synthesizing intermediates useful in the non-asymmetric or asymmetric methods for synthesizing enantiomerically enriched milnacipran or congeners thereof.
    Type: Grant
    Filed: April 1, 2005
    Date of Patent: December 18, 2007
    Assignee: Collegium Pharmaceutical, Inc.
    Inventors: Stephen L. Buchwald, Timothy M. Swager, Roman V. Rariy
  • Patent number: 7235695
    Abstract: Conformationally restricted polyamine compounds useful in treatment of cancer and other diseases marked by abnormal cell proliferation are disclosed. Improved methods of synthesizing such compounds are also disclosed. In one method of the invention, a carbene-bearing or carbene equivalent-bearing compound is reacted with the double bond of an alkene compound to form a cyclopropyl ring as the first step in the synthesis.
    Type: Grant
    Filed: August 16, 2005
    Date of Patent: June 26, 2007
    Inventors: Benjamin Frydman, Aldonia L. Valasinas, Andrei V. Blokhin, Aparajita Sarkar, Hirak S. Basu, Venodhar K. Reddy, Laurence J. Marton, Yu Wang
  • Patent number: 7026514
    Abstract: N,N?-bis(3-aminopropyl)cyclohexane-1,4-diamine, of formula (I), is a new compound that is prepared by hydrogenation with Raney nickel catalyst of N,N?-bis(2-cyanoethyl)-cyclohexane-1,4-diamine, the latter being prepared by reaction between 1,4-cyclohexanediamine and acrylonitrile. The oral administration to genetically alcoholic rats (from the strain UChB of the University of Chile) of the tetrametanesulfonate monohydrate of (I) causes a significant reduction in the alcohol consumption. The activity lasts for some time after the treatment period. Besides, there is a virtually null disulfiram-like adverse effect, what constitutes an advantage over the unpleasant use of some anti-alcoholism agents, such as calcium cyanamide or disulfiram itself.
    Type: Grant
    Filed: July 1, 2002
    Date of Patent: April 11, 2006
    Assignee: Garbil Pharma Investigacion Chile Ltda.
    Inventors: Norberto Bilbeny Lojo, Hernan Garcia Madrid, Maria Belen Font Arellano
  • Patent number: 6982351
    Abstract: Conformationally restricted polyamine compounds useful in treatment of cancer and other diseases marked by abnormal cell proliferation are disclosed. Improved methods of synthesizing such compounds are also disclosed. In one method of the invention, a carbene-bearing or carbene equivalent-bearing compound is reacted with the double bond of an alkene compound to form a cyclopropyl ring as the first step in the synthesis.
    Type: Grant
    Filed: December 6, 2002
    Date of Patent: January 3, 2006
    Assignee: CellGate, Inc.
    Inventors: Benjamin Frydman, Aldonia L. Valasinas, Andrei V. Blokhin, Aparajita Sarkar, Hirak S. Basu, Venodhar K. Reddy, Laurence J. Marton, Yu Wang
  • Patent number: 6919483
    Abstract: The synthesis and use of a novel class of tumor necrosis factor (TNF?) inhibitors and immunomodulators are provided. These compounds have pharmacological applications as well as uses in assays relating to TNF? and other involved cytokines. As pharmaceuticals, these compounds are used to treat inflammatory, infectious, autoimmune or other proliferative diseases and conditions related to the unwanted presence or activity of TNF? and/or one or more other involved cytokines, alone or in combination with other agents.
    Type: Grant
    Filed: May 23, 2003
    Date of Patent: July 19, 2005
    Assignee: Mediquest Therapeutics, Inc.
    Inventors: Mark R. Burns, Maralee McVean, Kevin J. Kennedy, Arthur Yeung, Bruce H. Devens
  • Patent number: 6583246
    Abstract: The invention provides modifiers for the anionic polymerization of conjugated dienes or of conjugated dienes with vinylaromatic compounds, wherein the modifiers are specific aminoethers.
    Type: Grant
    Filed: November 6, 2001
    Date of Patent: June 24, 2003
    Assignee: Bayer Aktiengesellschaft
    Inventors: Michael Grün, Thomas Knauf, Wilfried Braubach
  • Patent number: 6555959
    Abstract: A material for a light emitting device which is a compound represented by the following formula (I): wherein Ar1 and Ar6, which are the same or different, each represents a divalent aryl group or a divalent heterocyclic group; R2, R3, R7 and R8, which are the same or different, each represents an aryl group, a heterocyclic group or an aliphatic hydrocarbon group; R4a, R5a, R9a and R10a, which are the same or different, each represents a hydrogen atom or a monovalent group, and at least one of R4a, R5a, R9a and R10a represents an electron withdrawing group having a Hammett's &sgr;p value of 0.
    Type: Grant
    Filed: September 29, 2000
    Date of Patent: April 29, 2003
    Assignee: Fuji Photo Film Co., Ltd.
    Inventor: Kazumi Nii
  • Patent number: 6437186
    Abstract: Process for the preparation of isophorone diamine from isophorone nitrile, isophorone nitrilimine or mixtures containing isophorone nitrile and/or isophorone nitrilimine by hydrogenation through to amine in the presence of at least ammonia, hydrogen and a formed Raney hydrogenation catalyst based on cobalt, nickel, copper and/or iron, wherein the Raney catalyst is present in the form of hollow bodies.
    Type: Grant
    Filed: December 19, 2001
    Date of Patent: August 20, 2002
    Assignee: Degussa AG
    Inventors: Daniel Ostgard, Monika Berweiler, Stefan Roder, Jorg Sauer, Bernd Jaeger, Norbert Finke, Christian Lettmann
  • Patent number: 6417356
    Abstract: This invention relates to a composition containing (a) a component selected from the group of a mono- or poly- vinyl substituted mono- or poly-ether, a mono- or poly- vinyl substituted lactam, or a mixture thereof contained in an acidic medium and (b) an aliphatic, primary or secondary mono- or poly-amine at a concentration sufficient to adjust the pH of the composition above
    Type: Grant
    Filed: January 18, 2001
    Date of Patent: July 9, 2002
    Assignee: ISP Investments Inc.
    Inventors: Arvind M. Mathur, James A. Dougherty
  • Publication number: 20020072632
    Abstract: New ligands having a backbone comprised of NCCX can be combined with a metal or metal precursor compound or formed into a metal-ligand complex to catalyze a number of different chemical transformations, including polymerization.
    Type: Application
    Filed: February 1, 2002
    Publication date: June 13, 2002
    Applicant: Symyx Technologies
    Inventors: Anil S. Guram, Anne Marie LaPointe, Howard W. Turner, Tetsuo Uno
  • Patent number: 6369274
    Abstract: 1,n-cyclohexanediamines (n=2, 3, 4) of general formula (I), wherein one of the radicals R1 to R3 is an amino group and the two others mean hydrogen, are produced from the corresponding cyclohexanediols and ammonia in the presence of a catalyst containing cobalt, at 100° to 350° C. and 50 to 300 bar. The compounds that can be produced according to the invention are structural elements for polymers, especially polyamides, polyimides, polyurea or polyurethanes, and ligands for cytostatically effective transition metal complexes.
    Type: Grant
    Filed: July 20, 2001
    Date of Patent: April 9, 2002
    Assignee: Lonza AG
    Inventors: Alfons Baiker, Tamas Mallat, Achim Fischer
  • Patent number: 6255348
    Abstract: wherein R1, R2, R3 and R4 are selected independently from each other from —NR5R6, —NR5R6R7+, hydrogen, aryl or heteroaryl with up to 7 ring members, C1-C20-alkyl, C1-C20-alkenyl and C1-C20-alkinyl, wherein the alkyl, alkenyl and alkinyl residues can be branched, unbranched or cyclized and optionally substituted with halogen, aryl or heteroaryl with up to 7 ring members, with the proviso that at least one of the residues R1, R2, R3 and R4 are represented by —NR5R6 or —NR5R6R7; and R5, R6 and R7 are selected independently from each other from hydrogen, aryl or heteroaryl with up to 7 ring members, C1-C20-alkyl, C1-C20-alkenyl, C1-C20-alkinyl, wherein the alkyl, alkenyl and alkinyl residues can be branched, unbranched or cyclized and optionally substituted with halogen, aryl or heteroaryl with up to 7 ring members, or R5 and R6, together with the nitrogen atom, form a heterocyclic group with up to 7 ring members; for the regulation of the activity of already activat
    Type: Grant
    Filed: September 22, 2000
    Date of Patent: July 3, 2001
    Assignee: Merz + Co. GmbH & Co.
    Inventor: Erich F. Elstner
  • Patent number: 6242641
    Abstract: The present invention relates to compounds selected from formula I wherein R1, R2, R3 and R4 are the same or different and represent hydrogen, C1, to C6-alkyl, C5 to C6-cycloalkyl, phenyl and halogen, m and n are the same or different and represent the 2, 3, 4 or 5, X, A and B represent carbon and Y1, Y2, Z1 and Z2 are the same or different and represent hydrogen, hydroxyl (OH), amino (NH2), isocyanato (NCO) or 4-hydroxyphenyl.
    Type: Grant
    Filed: March 22, 1999
    Date of Patent: June 5, 2001
    Assignee: Bayer Aktiengesellschaft
    Inventors: Manfred Jautelat, Carl Casser, Hanns-Peter Müller, Manfred Hajek
  • Patent number: 6172116
    Abstract: wherein R1, R2, R3 and R4 are selected independently from each other from —NR5R6, —NR5R6R7+, hydrogen, aryl or heteroaryl with up to 7 ring members, C1-C20-alkyl, C1-C20-alkenyl and C1-C20-alkinyl, wherein the alkyl, alkenyl and alkinyl residues can be branched, unbranched or cyclized and optionally substituted with halogen, aryl or heteroaryl with up to 7 ring members, with the proviso that at least one of the residues R1, R2, R3 and R4 are represented by —NR5R6 or —NR5R6R7; and R5, R6 and R7 are selected independently from each other from hydrogen, aryl or heteroaryl with up to 7 ring members, C1-C20-alkyl, C1-C20-alkenyl, C1-C20-alkinyl, wherein the alkyl, alkenyl and alkinyl residues can be branched, unbranched or cyclized and optionally substituted with halogen, aryl or heteroaryl with up to 7 ring members, or R5 and R6, together with the nitrogen atom, form a heterocyclic group with up to 7 ring members; for the regulation of the activity of already activ
    Type: Grant
    Filed: July 31, 1998
    Date of Patent: January 9, 2001
    Assignee: Merz + Co. GmbH & Co.
    Inventor: Erich F. Elstner
  • Patent number: 6153748
    Abstract: A process for hydrogenating a compound in the group of the imines or enamines I to an amine II in the presence of a nitrile III, said nitrile III being essentially not hydrogenated comprises reacting a mixture comprising a compound I and a nitrile III with a gas comprising molecular hydrogen in the presence of a catalyst IV.
    Type: Grant
    Filed: August 9, 1999
    Date of Patent: November 28, 2000
    Assignee: BASF Aktiengesellschaft
    Inventors: Eberhard Fuchs, Frank Ohlbach
  • Patent number: 6140361
    Abstract: 2-Deoxystreptamine is an aminocyclitol whose structural stability and abundant functionality make it an attractive scaffold for the combinatorial generation of small molecules. The ability to selectively functionalize the various positions of 2-deoxystreptamine with an almost infinite number of different groups ensures that the libraries so generated will be both spatially and functionally diverse. These compounds can then be screened for biological activity to afford lead compounds for pharmaceutical programs. Additionally, biological ligand mimics based on 2-deoxystreptamine can be readily appended, either directly or through a tether, to solid surfaces or incorporated covalently into gels to afford novel materials useful in separation science.
    Type: Grant
    Filed: March 22, 1999
    Date of Patent: October 31, 2000
    Assignee: Scriptgen Pharmaceuticals, Inc.
    Inventors: Gary R. Gustafson, David G. Powers, Mark A. Wuonola