Preparing Directly From Hetero Ring Containing Compound Patents (Class 564/487)
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Patent number: 9072796Abstract: Disclosed are an intermediate compound of N-(1,1,1-trideuterated methyl)phthalimide, and its use in the preparation of deuterated diphenylurea derivative.Type: GrantFiled: November 27, 2013Date of Patent: July 7, 2015Assignee: SUZHOU ZELGEN BIOPHARMACEUTICAL CO., LTD.Inventors: Weidong Feng, Xiaoyong Gao, Xiaojun Dai
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Publication number: 20150148543Abstract: The invention features methods and compositions for the synthesis of multimerizing agents.Type: ApplicationFiled: January 28, 2015Publication date: May 28, 2015Inventors: Feng Li, Yihan Wang
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Patent number: 9024028Abstract: The invention features methods and compositions for the synthesis of multimerizing agents. An exemplary method for producing AP20187 may comprise: (a) coupling 2-N,Ndimethylaminomethyl-1,3-diaminopropane with AP20792 to produce the dimeric alcohol, AP20793; and (b) coupling the AP20793 so produced with API7362 to yield AP20187. In particular embodiments, the method further includes the step of producing API7362 by coupling API7360 with methyl-L-pipecolic acid, or a salt thereof.Type: GrantFiled: January 26, 2012Date of Patent: May 5, 2015Assignee: ARIAD Pharmaceuticals, Inc.Inventors: Feng Li, Yihan Wang
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Publication number: 20150045565Abstract: A carrier having at least three lobes, a first end, a second end, a wall between the ends and a non-uniform radius of transition at the intersection of an end and the wall is disclosed. A catalyst comprising the carrier, silver and promoters deposited on the carrier and useful for the epoxidation of olefins is also disclosed. A method for making the carrier, a method for making the catalyst and a process for epoxidation of an olefin with the catalyst are also disclosed.Type: ApplicationFiled: October 27, 2014Publication date: February 12, 2015Inventors: Michael A. Richard, John David Covey
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Patent number: 8927773Abstract: The invention relates to a process for preparing primary amines which comprises the process steps A) provision of a solution of a secondary alcohol in a fluid, nongaseous phase, B) contacting of the phase with free ammonia and/or at least one ammonia-releasing compound and a homogeneous catalyst and optionally C) isolation of the primary amine formed in process step B), characterized in that the volume ratio of the volume of the liquid phase to the volume of the gas phase in process step B is greater than or equal to 0.25, and/or in that the ammonia is used in process step B) in a molar ratio based on the hydroxyl groups in the secondary alcohol of at least 5:1.Type: GrantFiled: August 23, 2011Date of Patent: January 6, 2015Assignee: Evonik Degussa GmbHInventors: Florian Klasovsky, Jan Christoph Pfeffer, Thomas Tacke, Thomas Haas, Andreas Martin, Jens Deutsch, Angela Koeckritz
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Publication number: 20140252262Abstract: The present invention relates to whitening compositions, processes for obtaining such compositions, stable aqueous solutions of such compositions and the use of such compositions for whitening of textile fibers, paper and in detergency.Type: ApplicationFiled: October 25, 2012Publication date: September 11, 2014Inventors: Ferruccio Berte', Marco Brena, Massimo Fabbi, Francesco Maestri
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Publication number: 20140171649Abstract: The invention features methods and compositions for the synthesis of multimerizing agents. An exemplary method for producing AP20187 may comprise: (a) coupling 2-N,Ndimethylaminomethyl-1,3-diaminopropane with AP20792 to produce the dimeric alcohol, AP20793; and (b) coupling the AP20793 so produced with API7362 to yield AP20187. In particular embodiments, the method further includes the step of producing API7362 by coupling API7360 with methyl-L-pipecolic acid, or a salt thereof.Type: ApplicationFiled: January 26, 2012Publication date: June 19, 2014Applicant: ARIAD PHARMACEUTICALS, INC.Inventors: Feng Li, Yihan Wang
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Publication number: 20140163225Abstract: There is provided a process for the reduction of one or more amide moieties in a compound comprising contacting the compound with hydrogen gas and a transition metal catalyst in the presence or absence of a base under conditions for the reduction an amide bond. The presently described processes can be performed at low catalyst loading using relatively mild temperature and pressures, and optionally, in the presence or absence of a base or high catalyst loadings using low temperatures and pressures and high loadings of base to effect dynamic kinetic resolution of achiral amides.Type: ApplicationFiled: July 18, 2012Publication date: June 12, 2014Applicant: THE GOVERNORS OF THE UNIVERSITY OF ALBERTAInventors: Steven Bergens, Jeremy M. John
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Patent number: 8748666Abstract: Preparation methods of methyl-d3-amine and salts thereof are provided, which contain the following steps: (i) nitromethane is subjected to react with deuterium oxide in the present of bases and phase-transfer catalysts to form nitromethane-d3, which is subsequently subjected to reduction in an inert solvent to form methyl-d3-amine, and optionally, methyl-d3-amine reacts subsequently with acids to form salts of methyl-d3-amine; or (ii) N-(1,1,1-trideuteriomethyl)phthalimide is subjected to react with acids to form salts of methyl-d3-amine. The present methods are easy, high efficient, and low cost.Type: GrantFiled: March 17, 2011Date of Patent: June 10, 2014Assignee: Suzhou Zelgen Biopharmaceutical Co., Ltd.Inventors: Xiaoyong Gao, Weidong Feng, Xiaojun Dai
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Publication number: 20140088311Abstract: Disclosed are an intermediate compound of N-(1,1,1-trideuterated methyl)phthalimide, and its use in the preparation of deuterated diphenylurea derivative.Type: ApplicationFiled: November 27, 2013Publication date: March 27, 2014Applicant: SUZHOU ZELGEN BIOPHARMACEUTICAL CO., LTD.Inventors: Weidong FENG, Xiaoyong GAO, Xiaojun DAI
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Publication number: 20140088316Abstract: A supported silver catalyst and use thereof in a process for producing an alkylene oxide, such as ethylene oxide, by the direct oxidation of an alkylene with oxygen or an oxygen-containing gas, wherein the catalyst provides improved stability and improved resilience to reactor upsets and timely recovery to substantially pre-upset levels of catalyst activity and/or efficiency. In some embodiments, the catalyst also exhibits improved activity. A catalyst capable of producing ethylene oxide at a selectivity of at least 87 percent while achieving a work rate of at least 184 kg/h/m3 at a temperature of no greater than 235° C. when operated in a process where the inlet feed to a reactor containing the catalyst comprises ethylene, oxygen, and carbon dioxide, wherein the concentration of carbon dioxide in the inlet feed is greater than or equal to 2 mole percent.Type: ApplicationFiled: September 21, 2012Publication date: March 27, 2014Inventors: Manuel A. W. Natal, Madan M. Bhasin, Hwaili Soo, Albert C. Liu
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Patent number: 8669369Abstract: Methods and processes for preparation and production of deuterated ?-diphenylurea are disclosed. Especially, a kind of deuterated ?-diphenylurea compounds which can inhibit phosphokinase and the preparation method of N-(4-chloro-3-(trifluoromethyl)phenyl)-N?-(4-(2-(N-d3-methylcarbamoyl)-4-pridinyloxy)phenyl)urea are disclosed. The said deuterated diphenylurea compounds can be used for treating or preventing tumors and relative diseases.Type: GrantFiled: March 17, 2011Date of Patent: March 11, 2014Assignee: Suzhou Zelgen Biopharmaceutical Co., Ltd.Inventors: Weidong Feng, Xiaoyong Gao, Xiaojun Dai
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Publication number: 20130310555Abstract: Stereoselective and regioselective synthesis of compounds via nucleophilic ring opening reactions of aziridinium ions for use in stereoselective and regioselective synthesis of therapeutic and diagnostic compounds.Type: ApplicationFiled: May 17, 2013Publication date: November 21, 2013Applicant: Illinois Institute of TechnologyInventor: Hyun-Soon Chong
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Patent number: 8586795Abstract: The invention relates to a process for preparing triethylenetetramine substituted by at least one methyl group (Me-TETA or methyl-substituted TETA compounds). Me-TETA is prepared by hydrogenating biscyanomethylimidazolidine (BCMI) in the presence of a catalyst. The present invention further relates to methyl-substituted TETA compounds as such. The present invention further relates to the use of methyl-substituted TETA compounds as a reactant or intermediate in the production of, for example, coatings or adhesives.Type: GrantFiled: June 14, 2010Date of Patent: November 19, 2013Assignee: BASF SEInventors: Randolf Hugo, Johann-Peter Melder, Robert Baumann, Alfred Oftring, Boris Buschhaus, Gordon Brasche, Sebastian Ahrens, Peter Pfab
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Patent number: 8415503Abstract: Disclosed is a method for preparation of 1,1-diamino-2,2-dinitroethylene (DADNE) through the hydrolysis of 4,6-dihydroxy-5,5-dinitro-2-(dinitromethylene)-2,5-dihydropyrimidine (DHDNDP) obtained by the nitration of 4,6-dihydroxy-2-methylpyrimidine (DHMP), which can avoid eruption or sudden frothing of a reaction solution on a lab scale and even a large scale preparation as well as reduce the reaction time.Type: GrantFiled: July 6, 2011Date of Patent: April 9, 2013Assignee: Agency for Defense DevelopmentInventors: Eun Mee Goh, Jin Seuk Kim
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Publication number: 20130060044Abstract: Disclosed are an intermediate compound of N-(1,1,1-trideuterated methyl)phthalimide, and its use in the preparation of deuterated diphenylurea derivative.Type: ApplicationFiled: March 17, 2011Publication date: March 7, 2013Applicant: SUZHOU ZELGEN BIOPHARMACEUTICAL CO., LTD.Inventors: Weidong Feng, Xiaoyong Gao, Xiaojun Dai
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Patent number: 8357813Abstract: The invention provides a process for the epoxidation of an olefin, which process comprises reacting a feed comprising an olefin and oxygen in the presence of a catalyst comprising a carrier and silver deposited on the carrier, which carrier comprises at least 85 weight percent ?-alumina and has a surface area of at least 1.3 m2/g, a median pore diameter of more than 0.8 ?m, and a pore size distribution wherein at least 80% of the total pore volume is contained in pores with diameters in the range of from 0.1 to 10 ?m and at least 80% of the pore volume contained in the pores with diameters in the range of from 0.1 to 10 ?m is contained in pores with diameters in the range of from 0.3 to 10 ?m.Type: GrantFiled: November 18, 2011Date of Patent: January 22, 2013Assignee: Shell Oil CompanyInventors: William Herman Gerdes, John Robert Lockemeyer, Donald James Remus, Thomas Szymanski, Randall Clayton Yeates
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Patent number: 8357825Abstract: A process for preparing a 1,2-diol, a 1,2-diol ether or an alkanolamine comprising converting an olefin oxide, wherein the olefin oxide has been obtained by a process for the epoxidation of an olefin, said process comprising using a catalyst comprising a carrier and silver deposited thereon, wherein the carrier comprises at least 85 weight percent ?-alumina and has a surface area of at least 1.3 m2/g, a median pore diameter of more than 0.8 ?m, and a pore size distribution wherein at least 80% of the total pore is contained in pores with diameters in the range of from 0.1 to 10 ?m, and at least 80% of the pore volume contained in the pores with diameters in the range of from 0.1 to 10 ?m is contained in pores with diameters in the range of from 0.3 to 10 ?m.Type: GrantFiled: November 18, 2011Date of Patent: January 22, 2013Assignee: Shell Oil CompanyInventors: William Herman Gerdes, John Robert Lockemeyer, Donald James Remus, Thomas Szymanski, Randall Clayton Yeates
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Publication number: 20120323032Abstract: The present application relates to molecules comprising one or more beta-hydroxyamine moieties, for example, aminosilicones and compositions such as consumer products comprising such molecules, as well as processes for making and using such molecules and such compositions. The aforementioned process is safer, more efficient and thus more economical. Thus, the aforementioned moleculers may be more widely used.Type: ApplicationFiled: June 20, 2012Publication date: December 20, 2012Inventors: Bernard William KLUESENER, Robert Edward Shumate, Rajan Keshav Panandiker, Kenneth Edward Yelm
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Publication number: 20120323026Abstract: A catalyst for the epoxidation of an olefin comprising a carrier and, deposited thereon, silver, a rhenium promoter, a first co-promoter, and a second co-promoter; wherein the quantity of the rhenium promoter deposited on the carrier is greater than 1 mmole/kg, relative to the weight of the catalyst; the first co-promoter is selected from sulfur, phosphorus, boron, and mixtures thereof; the second co-promoter is selected from tungsten, molybdenum, chromium, and mixtures thereof; the total quantity of the first co-promoter and the second co-promoter deposited on the carrier is at most 5.0 mmole/kg, relative to the weight of the catalyst; and wherein the carrier has a monomodal, bimodal or multimodal pore size distribution, a pore diameter of 0.01-200 ?m, a specific surface area of 0.03-10 m2/g, a pore volume of 0.2-0.7 cm3/g, wherein the median pore diameter is 0.1-100 ?m, and a water absorption of 10-80%.Type: ApplicationFiled: February 24, 2011Publication date: December 20, 2012Inventors: John Robert Lockemeyer, Marek Matusz, Randall Clayton Yeates
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Publication number: 20120277447Abstract: The present invention relates to a process for improving the selectivity of an EO process utilizing a highly selective EO catalyst. In particular, the present invention is an improvement in the initial operation of a process for manufacturing ethylene oxide by contacting ethylene, oxygen, a chloride moderator and a hydrocarbon co-moderator with a high selectivity silver-containing catalyst at a concentration of carbon dioxide of less than about 2 mole percent, wherein the initial operating temperature is determined by optimization of such initial operating temperature at a level higher than the normal low initial operating temperature that is typically selected to obtain a longer operating cycle.Type: ApplicationFiled: April 26, 2012Publication date: November 1, 2012Applicant: SHELL OIL COMPANYInventors: Wayne Errol EVANS, Jeffrey Michael KOBE, Marek MATUSZ
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Publication number: 20120264979Abstract: A process for preparing N,N-dimethylaminoethoxyethanol (DMAEE), wherein a) dimethylamine and ethylene oxide are reacted, b) the resulting product mixture of N,N-dimethylethanolamine and DMAEE is separated by distillation to obtain a DMAEE-containing fraction as the bottom stream, and c) DMAEE from the fraction obtained in (b) is removed by distillation.Type: ApplicationFiled: March 15, 2012Publication date: October 18, 2012Applicant: BASF SEInventors: Frank-Friedrich Pape, Alfred Krause, Johann-Peter Melder, Bernd Stein, Joachim-Thierry Anders, Frank Haese
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Publication number: 20120259132Abstract: The invention is directed to a process to prepare an ethanol-derivate compound or compounds by reacting ethanol in the presence of molecular oxygen and a catalyst comprising a gamma-alumina carrier, metal nano-particles wherein the metal is selected from silver, copper or gold. The invention is also directed to processes to prepare such a catalyst.Type: ApplicationFiled: April 5, 2012Publication date: October 11, 2012Inventors: Meindert Jan Lippits, Bernard Egbert Nieuwenhuijs
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Publication number: 20120190867Abstract: A process for the preparation of 2,2-difluoroethylamine, comprising the reaction of 2,2-difluoro-1-chloroethane with an imide of the formula (II) in the presence of an acid scavenger, to give a compound of the formula (III) in which, in the compounds of the formulae (II) and (III), R1 and R2 are, each independently of one another, hydrogen or C1-C6-alkyl or R1 and R2 form, together with the carbon atoms to which they are bonded, a six-membered aromatic ring which is optionally substituted; and the cleavage of 2,2-difluoroethylamine by reaction of the compound of the formula (III) with acid, base or hydrazine.Type: ApplicationFiled: January 23, 2012Publication date: July 26, 2012Applicant: BAYER CROPSCIENCE AGInventors: Norbert LUI, Jens-Dietmar HEINRICH
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Publication number: 20120178968Abstract: Disclosed is a method for preparation of 1,1-diamino-2,2-dinitroethylene (DADNE) through the hydrolysis of 4,6-dihydroxy-5,5-dinitro-2-(dinitromethylene)-2,5-dihydropyrimidine (DHDNDP) obtained by the nitration of 4,6-dihydroxy-2-methylpyrimidine (DHMP), which can avoid eruption or sudden frothing of a reaction solution on a lab scale and even a large scale preparation as well as reduce the reaction time.Type: ApplicationFiled: July 6, 2011Publication date: July 12, 2012Inventors: Eun Mee Goh, Jin Seuk Kim
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Publication number: 20120171407Abstract: A carrier having at least three lobes, a first end, a second end, a wall between the ends and a non-uniform radius of transition at the intersection of an end and the wall is disclosed. A catalyst comprising the carrier, silver and promoters deposited on the carrier and useful for the epoxidation of olefins is also disclosed. A method for making the carrier, a method for making the catalyst and a process for epoxidation of an olefin with the catalyst are also disclosed.Type: ApplicationFiled: December 12, 2011Publication date: July 5, 2012Inventors: Michael A. RICHARD, John David Covey
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Publication number: 20120157715Abstract: A process for preparing an N,N-dialkylethanolamine of the formula I having high color stability where R1 and R2 are each independently a C1- to C8-alkyl group, by reacting ethylene oxide (EO) with a corresponding dialkylamine (R1R2NH) in the presence of water, wherein the reaction is effected continuously in a reactor, the reaction temperature is in the range from 90 to 180° C. and the residence time (RT) in the reactor is in the range from 1 to 7 min, the reactor output is treated thermally at a temperature in the range from 80 to 160° C. over a period in the range from 20 to 1000 min, and then the N,N-dialkylethanolamine is removed by distillation.Type: ApplicationFiled: December 16, 2011Publication date: June 21, 2012Applicant: BASF SEInventors: Frank-Friedrich Pape, Johann-Peter Melder, Alfred Krause, Roland Bou Chedid, Martin Rudloff
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Publication number: 20120101303Abstract: The invention relates to a process for preparing triethylenetetramine substituted by at least one methyl group (Me-TETA or methyl-substituted TETA compounds). Me-TETA is prepared by hydrogenating biscyanomethylimidazolidine (BCMI) in the presence of a catalyst. The present invention further relates to methyl-substituted TETA compounds as such. The present invention further relates to the use of methyl-substituted TETA compounds as a reactant or intermediate in the production of, for example, coatings or adhesives.Type: ApplicationFiled: June 14, 2010Publication date: April 26, 2012Applicant: BASF SEInventors: Randolf Hugo, Johann-Peter Melder, Robert Baumann, Alfred Oftring, Boris Buschhaus, Gordon Brasche, Sebastian Ahrens, Peter Pfab
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Publication number: 20120088891Abstract: The present invention relates to a process for the preparation of unsaturated acylamidoalkylpolyhydroxy acid amides by reacting the reaction product of polyhydroxy acid lactone and aliphatic diamine with the anhydride of a monounsaturated carboxylic acid, to the unsaturated acylamidoalkylpolyhydroxy acid amides and also to a process for the preparation of polymers of unsaturated acylamidoalkylpolyhydroxy acid amides.Type: ApplicationFiled: March 30, 2010Publication date: April 12, 2012Applicant: BASF SEInventors: Harald Keller, Mario Emmeluth, Tim Balensiefer, Paola Uribe Arocha, Francesca Aulenta
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Publication number: 20120053054Abstract: The present invention generally relates to a process for preparing the alkoxylated alkylamines and/or alkyl ether amines. The process consists of three stages, and utilizes an alkali catalyst. The alkoxylated alkyl amines and alkoxylated alkyl ether amines prepared by the process possess the peaked distribution and contain less hazardous by-product.Type: ApplicationFiled: September 12, 2011Publication date: March 1, 2012Applicant: AKZO NOBEL N.V.Inventors: Shawn Zhu, Giao Nguyen, Kha Nguyen, Alberto Slikta, David Eaton, David Becher, Henry Agbaje, Michael Seitz
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Publication number: 20120029203Abstract: Methods and intermediates for synthesizing triethylenetetramine and salts thereof, as well as novel triethylenetetramine salts and their crystal structure, and triethylenetetramine salts of high purity.Type: ApplicationFiled: October 7, 2011Publication date: February 2, 2012Applicant: PHILERA NEW ZEALAND LIMITEDInventors: Marco Jonas, Irene Vaulont, Antonio Soi, Gunther Schmidt
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Publication number: 20120016143Abstract: A catalyst for the epoxidation of an olefin comprising a carrier and deposited on the carrier, silver, a promoting amount of one or more promoters selected from the group consisting of alkali metals and rhenium and a promoting amount of nickel, wherein the nickel is added as a nickel compound or nickel complex during the initial impregnation along with the silver and other promoters; including a process for preparing the catalyst; a process for preparing an olefin oxide by reacting a feed comprising an olefin and oxygen in the presence of the catalyst; and a process for preparing a 1,2-diol, a 1,2-diol ether, a 1,2-carbonate, or an alkanolamine.Type: ApplicationFiled: July 11, 2011Publication date: January 19, 2012Applicant: SHELL OIL COMPANYInventor: Marek MATUSZ
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Patent number: 8084632Abstract: A method for enhancing the efficiency of a rhenium-promoted epoxidation catalyst is provided. Advantageously, the method may be carried out in situ, i.e., within the epoxidation process, and in fact, may be carried out during production of the desired epoxide. As such, a method for the epoxidation of alkylenes incorporating the efficiency-enhancing method is also provided, as is a method for using the alkylene oxides so produced for the production of 1,2-diols, 1,2-carbonates, 1,2-diol ethers, or alkanolamines.Type: GrantFiled: April 5, 2010Date of Patent: December 27, 2011Assignee: Dow Technology Investments LLCInventors: Albert C. Liu, Liping Zhang
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Publication number: 20110282081Abstract: Novel methods of synthesizing 1-deoxy-sphingoid bases and derivatives are disclosed. The synthesis is achieved from commercially available and inexpensive starting materials. The process includes thioesterification, cross-coupling, and reduction. The process may also include directed epoxidation, regioselective epoxide-opening, hydrogenation, and dihydroxylation. The methods described herein provide 1-deoxy-sphingoid bases and derivatives in high overall yield and high enantiomeric purity.Type: ApplicationFiled: January 21, 2010Publication date: November 17, 2011Applicant: EMORY UNIVERSITYInventors: Lanny S. Liebeskind, Ethel C. Garnier-Amblard, Dennis C. Liotta
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Publication number: 20110105771Abstract: A process for the epoxidation of an olefin comprising contacting a reactor feed comprising an olefin, oxygen, and carbon dioxide, with a catalyst comprising a carrier and, deposited on the carrier, silver, a rhenium promoter, a first co-promoter, and a second co-promoter; wherein the carbon dioxide is present in the reactor feed in a quantity of at most 3 mole percent based on the total epoxidation reactor feed; the first co-promoter is selected from sulfur, phosphorus, boron, and mixtures thereof; and the second co-promoter is selected from tungsten, molybdenum, chromium, and mixtures thereof; a process for preparing a 1,2-diol, a 1,2-diol ether, a 1,2-carbonate, or an alkanolamine.Type: ApplicationFiled: May 7, 2008Publication date: May 5, 2011Inventor: Marek Matusz
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Publication number: 20110071318Abstract: A reaction column (12) to which a raw material mixture (11) containing a mono-lower-alkylamine (AA: raw material I) and an alkylene oxide (AO: raw material II) is supplied, an unreacted raw material distillation column (14) that separates an unreacted raw material (15) from a reaction product (13a) (containing the unreacted raw material (15), a target reaction product (monomer) (17), and a by-product (dimer) (18)), and a flash drum (16) to which a reaction product (13b) (containing the target reaction product (monomer) (17) and the by-product (dimer) (18)) is supplied, the flash drum (16) separating a mono-lower-alkyl monoalkanolamine (monomer, the target reaction product 17) in a gas state, are provided.Type: ApplicationFiled: October 24, 2008Publication date: March 24, 2011Applicants: MITSUBISHI HEAVY INDUSTRIES, LTD., THE KANSAI ELECTRIC POWER CO., INC., NIPPON NYUKAZAI CO., LTD.Inventors: Tatsuya Tsujiuchi, Shinya Tachibana, Tsuyoshi Oishi, Tomio Mimura, Yasuyuki Yagi, Hidehisa Mita, Ryosuke Araki, Kenji Saito
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Publication number: 20100331234Abstract: Aminoalcohol lipidoids are prepared by reacting an amine with an epoxide-terminated compound are described. Methods of preparing aminoalcohol lipidoids from commercially available starting materials are also provided. Aminoalcohol lipidoids may be prepared from racemic or stereochemically pure epoxides. Aminoalcohol lipidoids or salts forms thereof are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these aminoalcohol lipidoid compounds, they are particularly suited for the delivery of polynucleotides. Complexes, micelles, liposomes or particles containing the inventive lipidoids and polynucleotide have been prepared. The inventive lipidoids may also be used in preparing microparticles for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.Type: ApplicationFiled: March 3, 2010Publication date: December 30, 2010Applicant: Massachusetts Institute of TechnologyInventors: Kerry Peter Mahon, Kevin Thomas Love, Christopher Gerard Levins, Kathryn Ann Whitehead, Robert S. Langer, Daniel G. Anderson
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Publication number: 20100267975Abstract: A method of producing an alkylene oxide includes passing a reaction mixture comprising alkylene, oxygen and a gaseous chlorine-containing promoter species over a supported catalyst containing silver and a promoting amount of rhenium to undergo an epoxidation reaction at a first operating condition. The method further includes subsequently performing the epoxidation reaction at a preferred operating condition. The preferred operating condition is characterized by an efficiency of the epoxidation reaction toward the alkylene oxide where the efficiency is lower than that of a maximum efficiency achievable at an operating temperature corresponding to the preferred operating condition.Type: ApplicationFiled: April 20, 2010Publication date: October 21, 2010Inventors: Michael Habenschuss, Hwaili Soo, Paul V. Hinman, Albert C. Liu
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Publication number: 20100267973Abstract: A method for enhancing the efficiency of a rhenium-promoted epoxidation catalyst is provided. Advantageously, the method may be carried out in situ, i.e., within the epoxidation process, and in fact, may be carried out during production of the desired epoxide. As such, a method for the epoxidation of alkylenes incorporating the efficiency-enhancing method is also provided, as is a method for using the alkylene oxides so produced for the production of 1,2-diols, 1,2-carbonates, 1,2-diol ethers, or alkanolamines.Type: ApplicationFiled: April 5, 2010Publication date: October 21, 2010Applicant: DOW TECHNOLOGY INVESTMENTS LLCInventors: Albert C. Liu, Liping Zhang
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Publication number: 20100173994Abstract: Methods and intermediates for synthesizing triethylenetetramine and salts thereof, as well as novel triethylenetetramine salts and their crystal structure, and triethylenetetramine salts of high purity.Type: ApplicationFiled: July 21, 2009Publication date: July 8, 2010Inventors: Marco Jonas, Irene Vaulont, Antonio Soi, Gunther Schmidt
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Publication number: 20100160655Abstract: A method for improving the selectivity of a supported highly selective epoxidation catalyst comprising silver in a quantity of at most 0.17 g per m2 surface area of the support, which method comprises contacting the catalyst, or a precursor of the catalyst comprising the silver in cationic form, with a feed comprising oxygen at a catalyst temperature above 250° C. for a duration of up to 150 hours, and subsequently decreasing the catalyst temperature to a value of at most 250° C.; and a process for the epoxidation of an olefin, which process comprises contacting a supported highly selective epoxidation catalyst comprising silver in a quantity of at most 0.17 g per m2 surface area of the support, or a precursor of the catalyst comprising the silver in cationic form, with a feed comprising oxygen at a catalyst temperature above 250° C. for a duration of up to 150 hours, and subsequently decreasing the catalyst temperature to a value of at most 250° C.Type: ApplicationFiled: December 18, 2008Publication date: June 24, 2010Inventors: John Robert LOCKEMEYER, Randall Clayton Yeates, Donald Reinalda
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Publication number: 20100016639Abstract: A method of selectively preparing a chiral 2S-amino alcohol useful in preparation of an amide sulfonated or acylated with alkyl, substituted aryl or substituted heteroaryl is described. The method involves reacting a di-tert-butyl diazene-1,2-dicarboxylate with a (4S)-4-benzyl-3-[(S)-trifluoromethyl-alkyl substituted alkanoyl]-1,3-oxazolidin-2-one to afford a di-tert-butyl 1-(1S,2S)-([(4S)-4-benzyl-2-oxo-1,3-oxazolidine-3-yl]-carbonyl}-trifluoromethyl-alkyl substituted alkyl)hydrazine-1,2-dicarboxylate. This dicarboxylate is then reduced to yield di-tert-butyl 1-(1S,2S)-[trifluoromethyl-alkyl substituted alkyl]hydrazine-1-(hydroxymethyl)-1,2-dicarboxylate. The resulting product is deblocked with an acid to yield the acid addition salt of (2S,3S)-trifluoro-hydrazino-methyl alkan-1-ol. The acid addition salt of (2S,3S)-trifluoro-2-hydrazino-methyl alkan-1-ol is hydrogenated in the presence of a suitable metal catalyst to yield the amino alcohol (2S,3S)-2-amino-trifluoro-methyl alkan-1-ol HCl.Type: ApplicationFiled: August 24, 2009Publication date: January 21, 2010Applicant: WyethInventors: John Sellstedt, Gloria Cheal, Razzak Noureldin, Anita Wai-Yin Chan, Panolil Raveendranath, Thomas Joseph Caggiano
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Publication number: 20090292132Abstract: A reactor system comprising: a reactor vessel, and positioned inside the reactor vessel, an absorbent and a catalyst positioned downstream from the absorbent; a process for reacting a feed; and a process for preparing a 1,2-diol, a 1,2-diol ether, a 1,2-carbonate, or an alkanolamine.Type: ApplicationFiled: May 15, 2008Publication date: November 26, 2009Inventor: Wayne Errol EVANS
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Patent number: 7612239Abstract: Method for the preparation of asymmetric alkynylated ?-amino esters of the formula wherein R1 and R2 are independently optionally substituted alkyl cycloalkyl, aryl or heteroaryl, and Y is hydrogen or a nitrogen protecting group.Type: GrantFiled: May 17, 2006Date of Patent: November 3, 2009Assignee: The Hong Kong Polytechnic UniversityInventors: Albert S Chan, Jian-Xin Ji, Jing Wu
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Patent number: 7582796Abstract: Methods and intermediates for synthesizing triethylenetetramine and salts thereof, as well as novel triethylenetetramine salts and their crystal structure, and triethylenetetramine salts of high purity.Type: GrantFiled: July 19, 2005Date of Patent: September 1, 2009Assignee: Protemix Corporation LimitedInventors: Marco Jonas, Irene Vaulont, Antonio Soi, Gunther Schmidt
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Publication number: 20090209788Abstract: The present invention generally relates to a process for preparing alkoxylated alkylamines and/or alkyl ether amines. The process consists of two stages and utilizes a catalyst with a multiple-charge counterion. The alkoxylated alkylamines and alkoxylated alkyl ether amines prepared by the process possess the peaked ethoxylation distribution and contain less hazardous by-product.Type: ApplicationFiled: June 21, 2007Publication date: August 20, 2009Applicant: AKZO NOBEL N.V.Inventors: Giao Vinh Nguyen, James Alfred Ragains, Kha Carl Dang Nguyen, Charles Woodville Davis
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Patent number: 7560520Abstract: Methods and systems for modifying a polymer are disclosed herein. A matrix is generally provided having a surface thereof, wherein the matrix comprises a plurality of hyperbranched polymers. The plurality of hyperbranched polymers can be chemically bound to a plurality of surfactants or order to modify the surface and produce a polymeric material thereof. The surface is tailored with a plurality of functional groups that self-assemble and are deliverable to the surface of the solution, including interfaces thereof, thereby permitting a high-density assembly of functional groups to operate in concert with one another in order to generate a modified surface thereof. The polymeric material produced thereof can be reversibly adaptable to environmental conditions through a blooming of varying surface functional group to the surface of the solution.Type: GrantFiled: November 7, 2005Date of Patent: July 14, 2009Assignee: The United States of America as represented by the Secretary of the ArmyInventors: Joshua A. Orlicki, Robert E. Jensen, Matthew S. Bratcher, Steven H. McKnight
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Publication number: 20090131695Abstract: A catalyst which comprises a carrier and silver deposited on the carrier, which carrier has a surface area of at least 1.3 m2/g, a median pore diameter of more than 0.8 ?m, and a pore size distribution wherein at least 80% of the total pore volume is contained in pores with diameters in the range of from 0.1 to 10 ?m and at least 80% of the pore volume contained in the pores with diameters in the range of from 0.1 to 10 ?m is contained in pores with diameters in the range of from 0.Type: ApplicationFiled: June 6, 2006Publication date: May 21, 2009Inventors: William Herman Gerdes, John Robert Lockemeyer, Donald James Remus, Thomas Szymanski, Randall Clayton Yeates
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Publication number: 20090124824Abstract: A process for producing a 6-hydroxycarpoic ester and a process for producing a trialkylamine in both of which nylon-6, ?-caprolactam, which is a monomer therefor, etc. are used as a raw material. The processes are intended to make nylon-6 wastes reusable in various applications without consuming a large quantity of energy. The process for producing a 6-hydroxycarpoic ester and process for producing a trialkylamine are characterized by reacting amide compounds basically comprising ?-caprolactam with an alcohol in a supercritical state to obtain a 6-hydroxycarpoic ester and a trialkylamine.Type: ApplicationFiled: January 24, 2007Publication date: May 14, 2009Applicants: YAMAGUCHI UNIVERSITY, UBE INDUSTRIES, LTD.Inventors: Akio Kamimura, Tsunemi Sugimoto, Kouji Kaiso
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Publication number: 20090030199Abstract: It is disclosed a process for the preparation of 2-(4-hydroxy-3-morfolinyl)-2-cycloesenone (BTG-1675A) comprising the steps of: i) reacting N-hydroxymorpholine with cycloesenone in the presence of an oxidation agent thus obtaining an isoxazolidine of Formula IV; and ii) converting the isoxazolidine of Formula IV into 2-(4-hydroxy-3-morfolinyl)-2-cycloesenone. Advantageously, the oxidation agent of the step i) is selected from the group consisting of metal oxides, esters and amides of the azodicarboxylic acid and the step ii) of conversion is carried out by basic catalysis followed by trituration in an aromatic hydrocarbon, preferably toluene. The process disclosed allows to obtain BTG-1675A according to the invention in an amount of hundreds of grams and on an industrial scale. The invention further concerns a new process for preparing hydroxylamines, particularly N-hydroxymorpholine, which is used in the process for preparing BTG-1675A.Type: ApplicationFiled: February 12, 2007Publication date: January 29, 2009Applicant: Abiogen Pharms S.P.AInventor: Elio Napolitano