Preparing Directly From Hetero Ring Containing Compound Patents (Class 564/487)
  • Patent number: 9072796
    Abstract: Disclosed are an intermediate compound of N-(1,1,1-trideuterated methyl)phthalimide, and its use in the preparation of deuterated diphenylurea derivative.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: July 7, 2015
    Assignee: SUZHOU ZELGEN BIOPHARMACEUTICAL CO., LTD.
    Inventors: Weidong Feng, Xiaoyong Gao, Xiaojun Dai
  • Publication number: 20150148543
    Abstract: The invention features methods and compositions for the synthesis of multimerizing agents.
    Type: Application
    Filed: January 28, 2015
    Publication date: May 28, 2015
    Inventors: Feng Li, Yihan Wang
  • Patent number: 9024028
    Abstract: The invention features methods and compositions for the synthesis of multimerizing agents. An exemplary method for producing AP20187 may comprise: (a) coupling 2-N,Ndimethylaminomethyl-1,3-diaminopropane with AP20792 to produce the dimeric alcohol, AP20793; and (b) coupling the AP20793 so produced with API7362 to yield AP20187. In particular embodiments, the method further includes the step of producing API7362 by coupling API7360 with methyl-L-pipecolic acid, or a salt thereof.
    Type: Grant
    Filed: January 26, 2012
    Date of Patent: May 5, 2015
    Assignee: ARIAD Pharmaceuticals, Inc.
    Inventors: Feng Li, Yihan Wang
  • Publication number: 20150045565
    Abstract: A carrier having at least three lobes, a first end, a second end, a wall between the ends and a non-uniform radius of transition at the intersection of an end and the wall is disclosed. A catalyst comprising the carrier, silver and promoters deposited on the carrier and useful for the epoxidation of olefins is also disclosed. A method for making the carrier, a method for making the catalyst and a process for epoxidation of an olefin with the catalyst are also disclosed.
    Type: Application
    Filed: October 27, 2014
    Publication date: February 12, 2015
    Inventors: Michael A. Richard, John David Covey
  • Patent number: 8927773
    Abstract: The invention relates to a process for preparing primary amines which comprises the process steps A) provision of a solution of a secondary alcohol in a fluid, nongaseous phase, B) contacting of the phase with free ammonia and/or at least one ammonia-releasing compound and a homogeneous catalyst and optionally C) isolation of the primary amine formed in process step B), characterized in that the volume ratio of the volume of the liquid phase to the volume of the gas phase in process step B is greater than or equal to 0.25, and/or in that the ammonia is used in process step B) in a molar ratio based on the hydroxyl groups in the secondary alcohol of at least 5:1.
    Type: Grant
    Filed: August 23, 2011
    Date of Patent: January 6, 2015
    Assignee: Evonik Degussa GmbH
    Inventors: Florian Klasovsky, Jan Christoph Pfeffer, Thomas Tacke, Thomas Haas, Andreas Martin, Jens Deutsch, Angela Koeckritz
  • Publication number: 20140252262
    Abstract: The present invention relates to whitening compositions, processes for obtaining such compositions, stable aqueous solutions of such compositions and the use of such compositions for whitening of textile fibers, paper and in detergency.
    Type: Application
    Filed: October 25, 2012
    Publication date: September 11, 2014
    Inventors: Ferruccio Berte', Marco Brena, Massimo Fabbi, Francesco Maestri
  • Publication number: 20140171649
    Abstract: The invention features methods and compositions for the synthesis of multimerizing agents. An exemplary method for producing AP20187 may comprise: (a) coupling 2-N,Ndimethylaminomethyl-1,3-diaminopropane with AP20792 to produce the dimeric alcohol, AP20793; and (b) coupling the AP20793 so produced with API7362 to yield AP20187. In particular embodiments, the method further includes the step of producing API7362 by coupling API7360 with methyl-L-pipecolic acid, or a salt thereof.
    Type: Application
    Filed: January 26, 2012
    Publication date: June 19, 2014
    Applicant: ARIAD PHARMACEUTICALS, INC.
    Inventors: Feng Li, Yihan Wang
  • Publication number: 20140163225
    Abstract: There is provided a process for the reduction of one or more amide moieties in a compound comprising contacting the compound with hydrogen gas and a transition metal catalyst in the presence or absence of a base under conditions for the reduction an amide bond. The presently described processes can be performed at low catalyst loading using relatively mild temperature and pressures, and optionally, in the presence or absence of a base or high catalyst loadings using low temperatures and pressures and high loadings of base to effect dynamic kinetic resolution of achiral amides.
    Type: Application
    Filed: July 18, 2012
    Publication date: June 12, 2014
    Applicant: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventors: Steven Bergens, Jeremy M. John
  • Patent number: 8748666
    Abstract: Preparation methods of methyl-d3-amine and salts thereof are provided, which contain the following steps: (i) nitromethane is subjected to react with deuterium oxide in the present of bases and phase-transfer catalysts to form nitromethane-d3, which is subsequently subjected to reduction in an inert solvent to form methyl-d3-amine, and optionally, methyl-d3-amine reacts subsequently with acids to form salts of methyl-d3-amine; or (ii) N-(1,1,1-trideuteriomethyl)phthalimide is subjected to react with acids to form salts of methyl-d3-amine. The present methods are easy, high efficient, and low cost.
    Type: Grant
    Filed: March 17, 2011
    Date of Patent: June 10, 2014
    Assignee: Suzhou Zelgen Biopharmaceutical Co., Ltd.
    Inventors: Xiaoyong Gao, Weidong Feng, Xiaojun Dai
  • Publication number: 20140088316
    Abstract: A supported silver catalyst and use thereof in a process for producing an alkylene oxide, such as ethylene oxide, by the direct oxidation of an alkylene with oxygen or an oxygen-containing gas, wherein the catalyst provides improved stability and improved resilience to reactor upsets and timely recovery to substantially pre-upset levels of catalyst activity and/or efficiency. In some embodiments, the catalyst also exhibits improved activity. A catalyst capable of producing ethylene oxide at a selectivity of at least 87 percent while achieving a work rate of at least 184 kg/h/m3 at a temperature of no greater than 235° C. when operated in a process where the inlet feed to a reactor containing the catalyst comprises ethylene, oxygen, and carbon dioxide, wherein the concentration of carbon dioxide in the inlet feed is greater than or equal to 2 mole percent.
    Type: Application
    Filed: September 21, 2012
    Publication date: March 27, 2014
    Inventors: Manuel A. W. Natal, Madan M. Bhasin, Hwaili Soo, Albert C. Liu
  • Publication number: 20140088311
    Abstract: Disclosed are an intermediate compound of N-(1,1,1-trideuterated methyl)phthalimide, and its use in the preparation of deuterated diphenylurea derivative.
    Type: Application
    Filed: November 27, 2013
    Publication date: March 27, 2014
    Applicant: SUZHOU ZELGEN BIOPHARMACEUTICAL CO., LTD.
    Inventors: Weidong FENG, Xiaoyong GAO, Xiaojun DAI
  • Patent number: 8669369
    Abstract: Methods and processes for preparation and production of deuterated ?-diphenylurea are disclosed. Especially, a kind of deuterated ?-diphenylurea compounds which can inhibit phosphokinase and the preparation method of N-(4-chloro-3-(trifluoromethyl)phenyl)-N?-(4-(2-(N-d3-methylcarbamoyl)-4-pridinyloxy)phenyl)urea are disclosed. The said deuterated diphenylurea compounds can be used for treating or preventing tumors and relative diseases.
    Type: Grant
    Filed: March 17, 2011
    Date of Patent: March 11, 2014
    Assignee: Suzhou Zelgen Biopharmaceutical Co., Ltd.
    Inventors: Weidong Feng, Xiaoyong Gao, Xiaojun Dai
  • Publication number: 20130310555
    Abstract: Stereoselective and regioselective synthesis of compounds via nucleophilic ring opening reactions of aziridinium ions for use in stereoselective and regioselective synthesis of therapeutic and diagnostic compounds.
    Type: Application
    Filed: May 17, 2013
    Publication date: November 21, 2013
    Applicant: Illinois Institute of Technology
    Inventor: Hyun-Soon Chong
  • Patent number: 8586795
    Abstract: The invention relates to a process for preparing triethylenetetramine substituted by at least one methyl group (Me-TETA or methyl-substituted TETA compounds). Me-TETA is prepared by hydrogenating biscyanomethylimidazolidine (BCMI) in the presence of a catalyst. The present invention further relates to methyl-substituted TETA compounds as such. The present invention further relates to the use of methyl-substituted TETA compounds as a reactant or intermediate in the production of, for example, coatings or adhesives.
    Type: Grant
    Filed: June 14, 2010
    Date of Patent: November 19, 2013
    Assignee: BASF SE
    Inventors: Randolf Hugo, Johann-Peter Melder, Robert Baumann, Alfred Oftring, Boris Buschhaus, Gordon Brasche, Sebastian Ahrens, Peter Pfab
  • Patent number: 8415503
    Abstract: Disclosed is a method for preparation of 1,1-diamino-2,2-dinitroethylene (DADNE) through the hydrolysis of 4,6-dihydroxy-5,5-dinitro-2-(dinitromethylene)-2,5-dihydropyrimidine (DHDNDP) obtained by the nitration of 4,6-dihydroxy-2-methylpyrimidine (DHMP), which can avoid eruption or sudden frothing of a reaction solution on a lab scale and even a large scale preparation as well as reduce the reaction time.
    Type: Grant
    Filed: July 6, 2011
    Date of Patent: April 9, 2013
    Assignee: Agency for Defense Development
    Inventors: Eun Mee Goh, Jin Seuk Kim
  • Publication number: 20130060044
    Abstract: Disclosed are an intermediate compound of N-(1,1,1-trideuterated methyl)phthalimide, and its use in the preparation of deuterated diphenylurea derivative.
    Type: Application
    Filed: March 17, 2011
    Publication date: March 7, 2013
    Applicant: SUZHOU ZELGEN BIOPHARMACEUTICAL CO., LTD.
    Inventors: Weidong Feng, Xiaoyong Gao, Xiaojun Dai
  • Patent number: 8357825
    Abstract: A process for preparing a 1,2-diol, a 1,2-diol ether or an alkanolamine comprising converting an olefin oxide, wherein the olefin oxide has been obtained by a process for the epoxidation of an olefin, said process comprising using a catalyst comprising a carrier and silver deposited thereon, wherein the carrier comprises at least 85 weight percent ?-alumina and has a surface area of at least 1.3 m2/g, a median pore diameter of more than 0.8 ?m, and a pore size distribution wherein at least 80% of the total pore is contained in pores with diameters in the range of from 0.1 to 10 ?m, and at least 80% of the pore volume contained in the pores with diameters in the range of from 0.1 to 10 ?m is contained in pores with diameters in the range of from 0.3 to 10 ?m.
    Type: Grant
    Filed: November 18, 2011
    Date of Patent: January 22, 2013
    Assignee: Shell Oil Company
    Inventors: William Herman Gerdes, John Robert Lockemeyer, Donald James Remus, Thomas Szymanski, Randall Clayton Yeates
  • Patent number: 8357813
    Abstract: The invention provides a process for the epoxidation of an olefin, which process comprises reacting a feed comprising an olefin and oxygen in the presence of a catalyst comprising a carrier and silver deposited on the carrier, which carrier comprises at least 85 weight percent ?-alumina and has a surface area of at least 1.3 m2/g, a median pore diameter of more than 0.8 ?m, and a pore size distribution wherein at least 80% of the total pore volume is contained in pores with diameters in the range of from 0.1 to 10 ?m and at least 80% of the pore volume contained in the pores with diameters in the range of from 0.1 to 10 ?m is contained in pores with diameters in the range of from 0.3 to 10 ?m.
    Type: Grant
    Filed: November 18, 2011
    Date of Patent: January 22, 2013
    Assignee: Shell Oil Company
    Inventors: William Herman Gerdes, John Robert Lockemeyer, Donald James Remus, Thomas Szymanski, Randall Clayton Yeates
  • Publication number: 20120323026
    Abstract: A catalyst for the epoxidation of an olefin comprising a carrier and, deposited thereon, silver, a rhenium promoter, a first co-promoter, and a second co-promoter; wherein the quantity of the rhenium promoter deposited on the carrier is greater than 1 mmole/kg, relative to the weight of the catalyst; the first co-promoter is selected from sulfur, phosphorus, boron, and mixtures thereof; the second co-promoter is selected from tungsten, molybdenum, chromium, and mixtures thereof; the total quantity of the first co-promoter and the second co-promoter deposited on the carrier is at most 5.0 mmole/kg, relative to the weight of the catalyst; and wherein the carrier has a monomodal, bimodal or multimodal pore size distribution, a pore diameter of 0.01-200 ?m, a specific surface area of 0.03-10 m2/g, a pore volume of 0.2-0.7 cm3/g, wherein the median pore diameter is 0.1-100 ?m, and a water absorption of 10-80%.
    Type: Application
    Filed: February 24, 2011
    Publication date: December 20, 2012
    Inventors: John Robert Lockemeyer, Marek Matusz, Randall Clayton Yeates
  • Publication number: 20120323032
    Abstract: The present application relates to molecules comprising one or more beta-hydroxyamine moieties, for example, aminosilicones and compositions such as consumer products comprising such molecules, as well as processes for making and using such molecules and such compositions. The aforementioned process is safer, more efficient and thus more economical. Thus, the aforementioned moleculers may be more widely used.
    Type: Application
    Filed: June 20, 2012
    Publication date: December 20, 2012
    Inventors: Bernard William KLUESENER, Robert Edward Shumate, Rajan Keshav Panandiker, Kenneth Edward Yelm
  • Publication number: 20120277447
    Abstract: The present invention relates to a process for improving the selectivity of an EO process utilizing a highly selective EO catalyst. In particular, the present invention is an improvement in the initial operation of a process for manufacturing ethylene oxide by contacting ethylene, oxygen, a chloride moderator and a hydrocarbon co-moderator with a high selectivity silver-containing catalyst at a concentration of carbon dioxide of less than about 2 mole percent, wherein the initial operating temperature is determined by optimization of such initial operating temperature at a level higher than the normal low initial operating temperature that is typically selected to obtain a longer operating cycle.
    Type: Application
    Filed: April 26, 2012
    Publication date: November 1, 2012
    Applicant: SHELL OIL COMPANY
    Inventors: Wayne Errol EVANS, Jeffrey Michael KOBE, Marek MATUSZ
  • Publication number: 20120264979
    Abstract: A process for preparing N,N-dimethylaminoethoxyethanol (DMAEE), wherein a) dimethylamine and ethylene oxide are reacted, b) the resulting product mixture of N,N-dimethylethanolamine and DMAEE is separated by distillation to obtain a DMAEE-containing fraction as the bottom stream, and c) DMAEE from the fraction obtained in (b) is removed by distillation.
    Type: Application
    Filed: March 15, 2012
    Publication date: October 18, 2012
    Applicant: BASF SE
    Inventors: Frank-Friedrich Pape, Alfred Krause, Johann-Peter Melder, Bernd Stein, Joachim-Thierry Anders, Frank Haese
  • Publication number: 20120259132
    Abstract: The invention is directed to a process to prepare an ethanol-derivate compound or compounds by reacting ethanol in the presence of molecular oxygen and a catalyst comprising a gamma-alumina carrier, metal nano-particles wherein the metal is selected from silver, copper or gold. The invention is also directed to processes to prepare such a catalyst.
    Type: Application
    Filed: April 5, 2012
    Publication date: October 11, 2012
    Inventors: Meindert Jan Lippits, Bernard Egbert Nieuwenhuijs
  • Publication number: 20120190867
    Abstract: A process for the preparation of 2,2-difluoroethylamine, comprising the reaction of 2,2-difluoro-1-chloroethane with an imide of the formula (II) in the presence of an acid scavenger, to give a compound of the formula (III) in which, in the compounds of the formulae (II) and (III), R1 and R2 are, each independently of one another, hydrogen or C1-C6-alkyl or R1 and R2 form, together with the carbon atoms to which they are bonded, a six-membered aromatic ring which is optionally substituted; and the cleavage of 2,2-difluoroethylamine by reaction of the compound of the formula (III) with acid, base or hydrazine.
    Type: Application
    Filed: January 23, 2012
    Publication date: July 26, 2012
    Applicant: BAYER CROPSCIENCE AG
    Inventors: Norbert LUI, Jens-Dietmar HEINRICH
  • Publication number: 20120178968
    Abstract: Disclosed is a method for preparation of 1,1-diamino-2,2-dinitroethylene (DADNE) through the hydrolysis of 4,6-dihydroxy-5,5-dinitro-2-(dinitromethylene)-2,5-dihydropyrimidine (DHDNDP) obtained by the nitration of 4,6-dihydroxy-2-methylpyrimidine (DHMP), which can avoid eruption or sudden frothing of a reaction solution on a lab scale and even a large scale preparation as well as reduce the reaction time.
    Type: Application
    Filed: July 6, 2011
    Publication date: July 12, 2012
    Inventors: Eun Mee Goh, Jin Seuk Kim
  • Publication number: 20120171407
    Abstract: A carrier having at least three lobes, a first end, a second end, a wall between the ends and a non-uniform radius of transition at the intersection of an end and the wall is disclosed. A catalyst comprising the carrier, silver and promoters deposited on the carrier and useful for the epoxidation of olefins is also disclosed. A method for making the carrier, a method for making the catalyst and a process for epoxidation of an olefin with the catalyst are also disclosed.
    Type: Application
    Filed: December 12, 2011
    Publication date: July 5, 2012
    Inventors: Michael A. RICHARD, John David Covey
  • Publication number: 20120157715
    Abstract: A process for preparing an N,N-dialkylethanolamine of the formula I having high color stability where R1 and R2 are each independently a C1- to C8-alkyl group, by reacting ethylene oxide (EO) with a corresponding dialkylamine (R1R2NH) in the presence of water, wherein the reaction is effected continuously in a reactor, the reaction temperature is in the range from 90 to 180° C. and the residence time (RT) in the reactor is in the range from 1 to 7 min, the reactor output is treated thermally at a temperature in the range from 80 to 160° C. over a period in the range from 20 to 1000 min, and then the N,N-dialkylethanolamine is removed by distillation.
    Type: Application
    Filed: December 16, 2011
    Publication date: June 21, 2012
    Applicant: BASF SE
    Inventors: Frank-Friedrich Pape, Johann-Peter Melder, Alfred Krause, Roland Bou Chedid, Martin Rudloff
  • Publication number: 20120101303
    Abstract: The invention relates to a process for preparing triethylenetetramine substituted by at least one methyl group (Me-TETA or methyl-substituted TETA compounds). Me-TETA is prepared by hydrogenating biscyanomethylimidazolidine (BCMI) in the presence of a catalyst. The present invention further relates to methyl-substituted TETA compounds as such. The present invention further relates to the use of methyl-substituted TETA compounds as a reactant or intermediate in the production of, for example, coatings or adhesives.
    Type: Application
    Filed: June 14, 2010
    Publication date: April 26, 2012
    Applicant: BASF SE
    Inventors: Randolf Hugo, Johann-Peter Melder, Robert Baumann, Alfred Oftring, Boris Buschhaus, Gordon Brasche, Sebastian Ahrens, Peter Pfab
  • Publication number: 20120088891
    Abstract: The present invention relates to a process for the preparation of unsaturated acylamidoalkylpolyhydroxy acid amides by reacting the reaction product of polyhydroxy acid lactone and aliphatic diamine with the anhydride of a monounsaturated carboxylic acid, to the unsaturated acylamidoalkylpolyhydroxy acid amides and also to a process for the preparation of polymers of unsaturated acylamidoalkylpolyhydroxy acid amides.
    Type: Application
    Filed: March 30, 2010
    Publication date: April 12, 2012
    Applicant: BASF SE
    Inventors: Harald Keller, Mario Emmeluth, Tim Balensiefer, Paola Uribe Arocha, Francesca Aulenta
  • Publication number: 20120053054
    Abstract: The present invention generally relates to a process for preparing the alkoxylated alkylamines and/or alkyl ether amines. The process consists of three stages, and utilizes an alkali catalyst. The alkoxylated alkyl amines and alkoxylated alkyl ether amines prepared by the process possess the peaked distribution and contain less hazardous by-product.
    Type: Application
    Filed: September 12, 2011
    Publication date: March 1, 2012
    Applicant: AKZO NOBEL N.V.
    Inventors: Shawn Zhu, Giao Nguyen, Kha Nguyen, Alberto Slikta, David Eaton, David Becher, Henry Agbaje, Michael Seitz
  • Publication number: 20120029203
    Abstract: Methods and intermediates for synthesizing triethylenetetramine and salts thereof, as well as novel triethylenetetramine salts and their crystal structure, and triethylenetetramine salts of high purity.
    Type: Application
    Filed: October 7, 2011
    Publication date: February 2, 2012
    Applicant: PHILERA NEW ZEALAND LIMITED
    Inventors: Marco Jonas, Irene Vaulont, Antonio Soi, Gunther Schmidt
  • Publication number: 20120016143
    Abstract: A catalyst for the epoxidation of an olefin comprising a carrier and deposited on the carrier, silver, a promoting amount of one or more promoters selected from the group consisting of alkali metals and rhenium and a promoting amount of nickel, wherein the nickel is added as a nickel compound or nickel complex during the initial impregnation along with the silver and other promoters; including a process for preparing the catalyst; a process for preparing an olefin oxide by reacting a feed comprising an olefin and oxygen in the presence of the catalyst; and a process for preparing a 1,2-diol, a 1,2-diol ether, a 1,2-carbonate, or an alkanolamine.
    Type: Application
    Filed: July 11, 2011
    Publication date: January 19, 2012
    Applicant: SHELL OIL COMPANY
    Inventor: Marek MATUSZ
  • Patent number: 8084632
    Abstract: A method for enhancing the efficiency of a rhenium-promoted epoxidation catalyst is provided. Advantageously, the method may be carried out in situ, i.e., within the epoxidation process, and in fact, may be carried out during production of the desired epoxide. As such, a method for the epoxidation of alkylenes incorporating the efficiency-enhancing method is also provided, as is a method for using the alkylene oxides so produced for the production of 1,2-diols, 1,2-carbonates, 1,2-diol ethers, or alkanolamines.
    Type: Grant
    Filed: April 5, 2010
    Date of Patent: December 27, 2011
    Assignee: Dow Technology Investments LLC
    Inventors: Albert C. Liu, Liping Zhang
  • Publication number: 20110282081
    Abstract: Novel methods of synthesizing 1-deoxy-sphingoid bases and derivatives are disclosed. The synthesis is achieved from commercially available and inexpensive starting materials. The process includes thioesterification, cross-coupling, and reduction. The process may also include directed epoxidation, regioselective epoxide-opening, hydrogenation, and dihydroxylation. The methods described herein provide 1-deoxy-sphingoid bases and derivatives in high overall yield and high enantiomeric purity.
    Type: Application
    Filed: January 21, 2010
    Publication date: November 17, 2011
    Applicant: EMORY UNIVERSITY
    Inventors: Lanny S. Liebeskind, Ethel C. Garnier-Amblard, Dennis C. Liotta
  • Publication number: 20110105771
    Abstract: A process for the epoxidation of an olefin comprising contacting a reactor feed comprising an olefin, oxygen, and carbon dioxide, with a catalyst comprising a carrier and, deposited on the carrier, silver, a rhenium promoter, a first co-promoter, and a second co-promoter; wherein the carbon dioxide is present in the reactor feed in a quantity of at most 3 mole percent based on the total epoxidation reactor feed; the first co-promoter is selected from sulfur, phosphorus, boron, and mixtures thereof; and the second co-promoter is selected from tungsten, molybdenum, chromium, and mixtures thereof; a process for preparing a 1,2-diol, a 1,2-diol ether, a 1,2-carbonate, or an alkanolamine.
    Type: Application
    Filed: May 7, 2008
    Publication date: May 5, 2011
    Inventor: Marek Matusz
  • Publication number: 20110071318
    Abstract: A reaction column (12) to which a raw material mixture (11) containing a mono-lower-alkylamine (AA: raw material I) and an alkylene oxide (AO: raw material II) is supplied, an unreacted raw material distillation column (14) that separates an unreacted raw material (15) from a reaction product (13a) (containing the unreacted raw material (15), a target reaction product (monomer) (17), and a by-product (dimer) (18)), and a flash drum (16) to which a reaction product (13b) (containing the target reaction product (monomer) (17) and the by-product (dimer) (18)) is supplied, the flash drum (16) separating a mono-lower-alkyl monoalkanolamine (monomer, the target reaction product 17) in a gas state, are provided.
    Type: Application
    Filed: October 24, 2008
    Publication date: March 24, 2011
    Applicants: MITSUBISHI HEAVY INDUSTRIES, LTD., THE KANSAI ELECTRIC POWER CO., INC., NIPPON NYUKAZAI CO., LTD.
    Inventors: Tatsuya Tsujiuchi, Shinya Tachibana, Tsuyoshi Oishi, Tomio Mimura, Yasuyuki Yagi, Hidehisa Mita, Ryosuke Araki, Kenji Saito
  • Publication number: 20100331234
    Abstract: Aminoalcohol lipidoids are prepared by reacting an amine with an epoxide-terminated compound are described. Methods of preparing aminoalcohol lipidoids from commercially available starting materials are also provided. Aminoalcohol lipidoids may be prepared from racemic or stereochemically pure epoxides. Aminoalcohol lipidoids or salts forms thereof are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these aminoalcohol lipidoid compounds, they are particularly suited for the delivery of polynucleotides. Complexes, micelles, liposomes or particles containing the inventive lipidoids and polynucleotide have been prepared. The inventive lipidoids may also be used in preparing microparticles for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
    Type: Application
    Filed: March 3, 2010
    Publication date: December 30, 2010
    Applicant: Massachusetts Institute of Technology
    Inventors: Kerry Peter Mahon, Kevin Thomas Love, Christopher Gerard Levins, Kathryn Ann Whitehead, Robert S. Langer, Daniel G. Anderson
  • Publication number: 20100267975
    Abstract: A method of producing an alkylene oxide includes passing a reaction mixture comprising alkylene, oxygen and a gaseous chlorine-containing promoter species over a supported catalyst containing silver and a promoting amount of rhenium to undergo an epoxidation reaction at a first operating condition. The method further includes subsequently performing the epoxidation reaction at a preferred operating condition. The preferred operating condition is characterized by an efficiency of the epoxidation reaction toward the alkylene oxide where the efficiency is lower than that of a maximum efficiency achievable at an operating temperature corresponding to the preferred operating condition.
    Type: Application
    Filed: April 20, 2010
    Publication date: October 21, 2010
    Inventors: Michael Habenschuss, Hwaili Soo, Paul V. Hinman, Albert C. Liu
  • Publication number: 20100267973
    Abstract: A method for enhancing the efficiency of a rhenium-promoted epoxidation catalyst is provided. Advantageously, the method may be carried out in situ, i.e., within the epoxidation process, and in fact, may be carried out during production of the desired epoxide. As such, a method for the epoxidation of alkylenes incorporating the efficiency-enhancing method is also provided, as is a method for using the alkylene oxides so produced for the production of 1,2-diols, 1,2-carbonates, 1,2-diol ethers, or alkanolamines.
    Type: Application
    Filed: April 5, 2010
    Publication date: October 21, 2010
    Applicant: DOW TECHNOLOGY INVESTMENTS LLC
    Inventors: Albert C. Liu, Liping Zhang
  • Publication number: 20100173994
    Abstract: Methods and intermediates for synthesizing triethylenetetramine and salts thereof, as well as novel triethylenetetramine salts and their crystal structure, and triethylenetetramine salts of high purity.
    Type: Application
    Filed: July 21, 2009
    Publication date: July 8, 2010
    Inventors: Marco Jonas, Irene Vaulont, Antonio Soi, Gunther Schmidt
  • Publication number: 20100160655
    Abstract: A method for improving the selectivity of a supported highly selective epoxidation catalyst comprising silver in a quantity of at most 0.17 g per m2 surface area of the support, which method comprises contacting the catalyst, or a precursor of the catalyst comprising the silver in cationic form, with a feed comprising oxygen at a catalyst temperature above 250° C. for a duration of up to 150 hours, and subsequently decreasing the catalyst temperature to a value of at most 250° C.; and a process for the epoxidation of an olefin, which process comprises contacting a supported highly selective epoxidation catalyst comprising silver in a quantity of at most 0.17 g per m2 surface area of the support, or a precursor of the catalyst comprising the silver in cationic form, with a feed comprising oxygen at a catalyst temperature above 250° C. for a duration of up to 150 hours, and subsequently decreasing the catalyst temperature to a value of at most 250° C.
    Type: Application
    Filed: December 18, 2008
    Publication date: June 24, 2010
    Inventors: John Robert LOCKEMEYER, Randall Clayton Yeates, Donald Reinalda
  • Publication number: 20100016639
    Abstract: A method of selectively preparing a chiral 2S-amino alcohol useful in preparation of an amide sulfonated or acylated with alkyl, substituted aryl or substituted heteroaryl is described. The method involves reacting a di-tert-butyl diazene-1,2-dicarboxylate with a (4S)-4-benzyl-3-[(S)-trifluoromethyl-alkyl substituted alkanoyl]-1,3-oxazolidin-2-one to afford a di-tert-butyl 1-(1S,2S)-([(4S)-4-benzyl-2-oxo-1,3-oxazolidine-3-yl]-carbonyl}-trifluoromethyl-alkyl substituted alkyl)hydrazine-1,2-dicarboxylate. This dicarboxylate is then reduced to yield di-tert-butyl 1-(1S,2S)-[trifluoromethyl-alkyl substituted alkyl]hydrazine-1-(hydroxymethyl)-1,2-dicarboxylate. The resulting product is deblocked with an acid to yield the acid addition salt of (2S,3S)-trifluoro-hydrazino-methyl alkan-1-ol. The acid addition salt of (2S,3S)-trifluoro-2-hydrazino-methyl alkan-1-ol is hydrogenated in the presence of a suitable metal catalyst to yield the amino alcohol (2S,3S)-2-amino-trifluoro-methyl alkan-1-ol HCl.
    Type: Application
    Filed: August 24, 2009
    Publication date: January 21, 2010
    Applicant: Wyeth
    Inventors: John Sellstedt, Gloria Cheal, Razzak Noureldin, Anita Wai-Yin Chan, Panolil Raveendranath, Thomas Joseph Caggiano
  • Publication number: 20090292132
    Abstract: A reactor system comprising: a reactor vessel, and positioned inside the reactor vessel, an absorbent and a catalyst positioned downstream from the absorbent; a process for reacting a feed; and a process for preparing a 1,2-diol, a 1,2-diol ether, a 1,2-carbonate, or an alkanolamine.
    Type: Application
    Filed: May 15, 2008
    Publication date: November 26, 2009
    Inventor: Wayne Errol EVANS
  • Patent number: 7612239
    Abstract: Method for the preparation of asymmetric alkynylated ?-amino esters of the formula wherein R1 and R2 are independently optionally substituted alkyl cycloalkyl, aryl or heteroaryl, and Y is hydrogen or a nitrogen protecting group.
    Type: Grant
    Filed: May 17, 2006
    Date of Patent: November 3, 2009
    Assignee: The Hong Kong Polytechnic University
    Inventors: Albert S Chan, Jian-Xin Ji, Jing Wu
  • Patent number: 7582796
    Abstract: Methods and intermediates for synthesizing triethylenetetramine and salts thereof, as well as novel triethylenetetramine salts and their crystal structure, and triethylenetetramine salts of high purity.
    Type: Grant
    Filed: July 19, 2005
    Date of Patent: September 1, 2009
    Assignee: Protemix Corporation Limited
    Inventors: Marco Jonas, Irene Vaulont, Antonio Soi, Gunther Schmidt
  • Publication number: 20090209788
    Abstract: The present invention generally relates to a process for preparing alkoxylated alkylamines and/or alkyl ether amines. The process consists of two stages and utilizes a catalyst with a multiple-charge counterion. The alkoxylated alkylamines and alkoxylated alkyl ether amines prepared by the process possess the peaked ethoxylation distribution and contain less hazardous by-product.
    Type: Application
    Filed: June 21, 2007
    Publication date: August 20, 2009
    Applicant: AKZO NOBEL N.V.
    Inventors: Giao Vinh Nguyen, James Alfred Ragains, Kha Carl Dang Nguyen, Charles Woodville Davis
  • Patent number: 7560520
    Abstract: Methods and systems for modifying a polymer are disclosed herein. A matrix is generally provided having a surface thereof, wherein the matrix comprises a plurality of hyperbranched polymers. The plurality of hyperbranched polymers can be chemically bound to a plurality of surfactants or order to modify the surface and produce a polymeric material thereof. The surface is tailored with a plurality of functional groups that self-assemble and are deliverable to the surface of the solution, including interfaces thereof, thereby permitting a high-density assembly of functional groups to operate in concert with one another in order to generate a modified surface thereof. The polymeric material produced thereof can be reversibly adaptable to environmental conditions through a blooming of varying surface functional group to the surface of the solution.
    Type: Grant
    Filed: November 7, 2005
    Date of Patent: July 14, 2009
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Joshua A. Orlicki, Robert E. Jensen, Matthew S. Bratcher, Steven H. McKnight
  • Publication number: 20090131695
    Abstract: A catalyst which comprises a carrier and silver deposited on the carrier, which carrier has a surface area of at least 1.3 m2/g, a median pore diameter of more than 0.8 ?m, and a pore size distribution wherein at least 80% of the total pore volume is contained in pores with diameters in the range of from 0.1 to 10 ?m and at least 80% of the pore volume contained in the pores with diameters in the range of from 0.1 to 10 ?m is contained in pores with diameters in the range of from 0.
    Type: Application
    Filed: June 6, 2006
    Publication date: May 21, 2009
    Inventors: William Herman Gerdes, John Robert Lockemeyer, Donald James Remus, Thomas Szymanski, Randall Clayton Yeates
  • Publication number: 20090124824
    Abstract: A process for producing a 6-hydroxycarpoic ester and a process for producing a trialkylamine in both of which nylon-6, ?-caprolactam, which is a monomer therefor, etc. are used as a raw material. The processes are intended to make nylon-6 wastes reusable in various applications without consuming a large quantity of energy. The process for producing a 6-hydroxycarpoic ester and process for producing a trialkylamine are characterized by reacting amide compounds basically comprising ?-caprolactam with an alcohol in a supercritical state to obtain a 6-hydroxycarpoic ester and a trialkylamine.
    Type: Application
    Filed: January 24, 2007
    Publication date: May 14, 2009
    Applicants: YAMAGUCHI UNIVERSITY, UBE INDUSTRIES, LTD.
    Inventors: Akio Kamimura, Tsunemi Sugimoto, Kouji Kaiso
  • Publication number: 20090030199
    Abstract: It is disclosed a process for the preparation of 2-(4-hydroxy-3-morfolinyl)-2-cycloesenone (BTG-1675A) comprising the steps of: i) reacting N-hydroxymorpholine with cycloesenone in the presence of an oxidation agent thus obtaining an isoxazolidine of Formula IV; and ii) converting the isoxazolidine of Formula IV into 2-(4-hydroxy-3-morfolinyl)-2-cycloesenone. Advantageously, the oxidation agent of the step i) is selected from the group consisting of metal oxides, esters and amides of the azodicarboxylic acid and the step ii) of conversion is carried out by basic catalysis followed by trituration in an aromatic hydrocarbon, preferably toluene. The process disclosed allows to obtain BTG-1675A according to the invention in an amount of hundreds of grams and on an industrial scale. The invention further concerns a new process for preparing hydroxylamines, particularly N-hydroxymorpholine, which is used in the process for preparing BTG-1675A.
    Type: Application
    Filed: February 12, 2007
    Publication date: January 29, 2009
    Applicant: Abiogen Pharms S.P.A
    Inventor: Elio Napolitano