The Benzene Ring Is Part Of A Substituent Which Contains Nitrogen Patents (Class 564/50)
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Patent number: 11118214Abstract: The invention provides methods and compositions for hybridizing at least one molecule to a target. The invention may, for example, eliminate the use of or reduce the dependence on formamide in hybridization. Compositions for use in the invention include an aqueous composition comprising at least one nucleic acid sequence and at least one polar aprotic solvent in an amount effective to denature double-stranded nucleotide sequences.Type: GrantFiled: May 27, 2009Date of Patent: September 14, 2021Assignee: AGILENT TECHNOLOGIES, INC.Inventors: Steen Hauge Matthiesen, Kenneth H. Petersen, Tim Svenstrup Poulsen, Charles M. Hansen
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Patent number: 9266826Abstract: An embodiment of the present invention is a separating agent wherein a group represented by a chemical formula of: or a group represented by a chemical formula of: is introduced on a surface thereof.Type: GrantFiled: January 31, 2013Date of Patent: February 23, 2016Assignees: SHISEIDO COMPANY, LTD., KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATIONInventors: Kenji Hamase, Masashi Mita, Yousuke Toujo, Yukimitsu Suda
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Patent number: 8921426Abstract: A cationic bis-urea compound is disclosed of formula (1): wherein: each m is independently an integer of 0 to 4, each k is independently 0 or 1, each Z? is a monovalent radical independently selected from the group consisting of hydroxyl (*—OH), carboxyl (*—COOH), cyano (*—CN), nitro (*—NO2), sulfonate (*—SO3?), trifluoromethyl (*—CF3), halides, amine groups, ketone groups, alkyl groups comprising 1 to 6 carbons, alkoxy groups comprising 1 to 6 carbons, thioether groups comprising 1 to 6 carbons, and combinations thereof, each L? is independently a divalent alkylene group comprising 1 to 6 carbons, wherein a *-[-L?-]k- is a single bond when k is 0, each Y? is independently a monovalent non-polymeric radical comprising a positive charged amine, and each X? is independently a negative charged counterion.Type: GrantFiled: April 18, 2012Date of Patent: December 30, 2014Assignees: International Business Machines Corporation, Agency For Science, Technology And ResearchInventors: Daniel Joseph Coady, Amanda Catherine Engler, Kazuki Fukushima, James Lupton Hedrick, Shaoqiong Liu, Hareem Tariq Maune, Alshakim Nelson, Jed Walter Pitera, Yi Yan Yang
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Publication number: 20140378705Abstract: An embodiment of the present invention is a separating agent wherein a group represented by a chemical formula of: or a group represented by a chemical formula of: is introduced on a surface thereof.Type: ApplicationFiled: January 31, 2013Publication date: December 25, 2014Inventors: Kenji Hamase, Masashi Mita, Yousuke Toujo, Yukimitsu Suda
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Publication number: 20140308317Abstract: The present disclosure provides compounds, or pharmaceutically acceptable salts thereof, for inhibiting the growth of a microbe; treating a mammal having a microbial infection, malaria, mucositis, an ophthalmic infection, an otic infection, a cancer, or a Mycobacterium infection; killing or inhibiting the growth of a Plasmodium species; inhibiting the growth of a Mycobacterium species; modulating an immune response in a mammal; or antagonizing unfractionated heparin, low molecular weight heparin, or a heparin/low molecular weight heparin derivative.Type: ApplicationFiled: December 9, 2013Publication date: October 16, 2014Applicant: CELLCEUTIX CORPORATIONInventors: Xiaodong Fan, Yongjiang Xu, Dahui Liu, Michael J. Costanzo
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Patent number: 8772540Abstract: Provided is a thermal responsive molecule favorable as a thermal responsive low-molecular hydrogelling agent or the like that gels in response to heat. The thermal responsive molecule is characterized in that an amphiphilic side chain obtained by bonding a hydrophilic side chain such as triethylene glycol and a hydrophobic group such as an octyl group is introduced into a C3-symmetric disc-shaped molecular skeleton such as 1,3,5-benzenetriyltriurea. For example, the thermal responsive molecule is 1,1?,1?-(benzene-1,3,5-triyl)tris{3-(2,5,8,11-tetraoxaheptadecan-17-yl)urea} or the like.Type: GrantFiled: November 19, 2010Date of Patent: July 8, 2014Assignee: Kyushu University, National University CorporationInventors: Noboru Koga, Satoru Karasawa, Hiroyuki Hayashi
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Patent number: 8697758Abstract: A urea compound of the present invention is represented by general formula (I) shown below: wherein each of X1, X2 and X3 independently represents a hydrogen atom, an alkyl group or an aryl group. The aryl group may have one or more functional groups selected from the group consisting of halogen groups, alkyl groups and alkoxy groups.Type: GrantFiled: September 15, 2009Date of Patent: April 15, 2014Assignees: National University Corporation Shizuoka University, Nissian Chemical Industries, Ltd.Inventor: Masamichi Yamanaka
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Patent number: 8609881Abstract: The present invention provides compound(s) selected from the group of compounds represented by structural Formula (I): wherein X, Y and R1 are as described herein, use of such compounds as anaerobic cure accelerators, and compostions including such compounds.Type: GrantFiled: May 7, 2008Date of Patent: December 17, 2013Assignee: Henkel IP US LCCInventors: Andrew Messana, Anthony F. Jacobine, Steven Thomas Nakos, David M. Glaser
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Publication number: 20130178494Abstract: The present disclosure relates to new DNA-directed alkylating agents and water-soluble N-mustard agents with improved chemical stability and anti-tumor therapeutic efficacy.Type: ApplicationFiled: June 29, 2012Publication date: July 11, 2013Applicant: Academia SinicaInventors: Tsann-Long SU, Ting-Chao Chou, Te-Chuang Lee
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Publication number: 20130079542Abstract: A preparation of aryl carbamates can be achieved readily by carbonylation of an aromatic polyamine compound with diphenyl carbonate (DPC) using a combination of an organic acid and a tertiary amine as a catalyst. Aryl carbamate can be converted into 4,4?-diphenylmethane diisocyanate (MDI) by heating it at about 200 to about 230° C. in a non-polar solvent containing inhibitor such as benzoyl chloride. In another application, trans-ureation of biscarbamates with an amine or mixed amines is found to be extremely facile in a polar solvent such as dimethyl sulfoxide (DMSO) and tetramethylene sulfone (TMS) in absence of any catalyst to make polyurea polymers of high molecular weights. Thus, efficient green-chemistry processes based on biscarbamates in making isocyanate products as well as urea prepolymers, urea elastomers and urea plastics have been developed in all in excellent yields without using reactive phosgene or 4,4?-diphenylmethane diisocyanate separately in the trans-ureation polymerizations.Type: ApplicationFiled: September 22, 2011Publication date: March 28, 2013Applicants: National Chung Hsing University, Great Eastern Resins Industrial Co., Ltd.Inventors: Shenghong A. Dai, Xue-Yong Chen, Chao-Hsing Lin, Chun-Ying Huang, Wen-Chen Pan
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Publication number: 20130078283Abstract: Disclosed herein is a compound of structure (A): In this compound, X is either O or S, R1 is a rigid group, R2 is a hydrophilic group such that (A) is capable of self-assembly in water, and R3 is an organic group.Type: ApplicationFiled: January 6, 2011Publication date: March 28, 2013Inventors: Yi-Yan Yang, Shrinivas Venkataraman
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Publication number: 20130065963Abstract: The invention provides novel classes of HDAC inhibitors. Methods of sensitizing a cancer cell to the cytotoxic effects of radiotherapy are also provided as well as methods for treating cancer and methods for treating neurological diseases. Additionally, the invention further provides pharmaceutical compositions comprising an HDAC inhibitor of the invention, and kits comprising a container containing an HDAC inhibitor of the invention.Type: ApplicationFiled: July 17, 2012Publication date: March 14, 2013Applicant: Georgetown UniversityInventors: Alan P. Kozikowski, Anatoly Dritschilo, Mira Jung, Pavel A. Petukhov, Bin Chen
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Publication number: 20130005803Abstract: The use of compounds in the treatment of skin disorders is described. In particular, the use of a compound of formula (I) or one of its pharmaceutically acceptable salts, pharmaceutically acceptable solvates or hydrates in the preparation of a medicament to treat inflammatory skin pathologies is described.Type: ApplicationFiled: December 15, 2010Publication date: January 3, 2013Applicant: GALDERMA RESEARCH & DEVELOPMENTInventor: Jérôme Aubert
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Patent number: 8283453Abstract: The present invention provides a method for selectively placing carbon nanotubes on a substrate surface by using functionalized carbon nanotubes having an organic compound that is covalently bonded to such carbon nanotubes. The organic compound comprises at least two functional groups, the first of which is capable of forming covalent bonds with carbon nanotubes, and the second of which is capable of selectively bonding metal oxides. Such functionalized carbon nanotubes are contacted with a substrate surface that has at least one portion containing a metal oxide. The second functional group of the organic compound selectively bonds to the metal oxide, so as to selectively place the functionalized carbon nanotubes on the at least one portion of the substrate surface that comprises the metal oxide.Type: GrantFiled: August 14, 2009Date of Patent: October 9, 2012Assignee: International Business Machines CorporationInventors: Ali Afzali-Ardakani, Phaedon Avouris, James B. Hannon, Christian Klinke
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Publication number: 20120214785Abstract: The invention relates to new compounds of the formula I to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.Type: ApplicationFiled: August 17, 2011Publication date: August 23, 2012Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBHInventors: Gerald Juergen ROTH, Martin FLECK, Niklas HEINE, Joerg KLEY, Thorsten LEHMANN-LINTZ, Heike NEUBAUER, Bernd NOSSE
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Patent number: 8222297Abstract: New aniline or phenol N-mustards linked to DNA-affinity carriers (such as 9-anilinoacridines, acridines and quinolines), aminobenzamides or aminophenol ethers by a urea, carbamic acid, carbanic acid ester, hydrazineurea, hydrazinecarbamic acid ester, phenoxyurea, phenoxycarbamic acid ester linkage with improved chemical stability and anti-tumor therapeutic efficacy are provided.Type: GrantFiled: January 11, 2008Date of Patent: July 17, 2012Assignee: Academia SinicaInventors: Tsann-Long Su, Ting-Chao Chou
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Patent number: 8143364Abstract: Process for preparing a composition by reacting a polyisocyanate, a monoalkoxy polyoxyalkylene monoamine and water. The composition and its use in making cellular products are claimed as well.Type: GrantFiled: February 12, 2007Date of Patent: March 27, 2012Assignee: Huntsman International LLCInventors: Gerhard Jozef Bleys, Hans Godelieve Guido Verbeke
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Publication number: 20120031775Abstract: The present invention relates to the synthesis of lipophilic or immobilized monobasic phosphate (H2PO4) ionophores (7, 8a, 8b and 11) to be used as ion recognition molecules for monobasic phosphate (H2PO4?) in the cocktail preparation of hydrophobic polymer membranes in ion selective electrode (ISE) or ion-sensitive field effect transistor (ISFET) chemical sensors for detection of monobasic phosphate (H2PO4) ionic species in soil, synthetic media, hydrophonic liquid, tree sap, ground water and rivers.Type: ApplicationFiled: October 27, 2009Publication date: February 9, 2012Applicant: MIMOS BERHADInventor: Mohd Rais Ahmad
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Patent number: 8084641Abstract: The present invention is directed to compositions comprising organocatalysts that facilitate stereo-selective reactions and the method of their synthesis and use. Particularly, the invention relates to metal-free organocatalysts for facilitation of stereo-selective reactions, and the method of their synthesis and use.Type: GrantFiled: October 11, 2006Date of Patent: December 27, 2011Assignee: STC.UNMInventor: Wei Wang
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Publication number: 20110311813Abstract: Nanostructures are formed from alkylated derivatives of aromatic acids of the formula: wherein at least one of R1 to R6 represents a carboxylic acid group, a primary amide group, an ester group, an amidine group, or a salt thereof, at least one other of R1 to R6 is X—Rc, and the remaining of R1 to R6 independently represent H or substituted or unsubstituted organic groups; X represents a linking group; and Rc represents a substituted or unsubstituted alkyl group.Type: ApplicationFiled: June 22, 2010Publication date: December 22, 2011Applicants: NATIONAL RESEARCH COUNCIL OF CANADA, XEROX CORPORATIONInventors: Darren Andrew MAKEIFF, Rina Carlini
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Patent number: 8071810Abstract: The present invention is related to a compound, preferably a C5a receptor antagonist, having the following structure, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, R20, R21 and R22 are individually and independently selected from the group comprising H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, arylalkyl, substituted arylalkyl, heteroarylalkyl, substituted heteroarylalkyl, alkoxyl, substituted alkoxyl, aryloxy, substituted aryloxy, arylalkyloxy, substituted arylalkyloxy, acyloxy, substituted acyloxy, halogen, hydroxyl, nitro, cyano, acyl, substituted acyl, mercapto, alkylthio, substituted alkylthio, amino, substituted amino, alkylamino, substituted alkylamino, bisalkyl amino, substituted bisalkyl amino, cyclic amino, substituted cyclic amino, carbamoyl (—CONH2), substituted carbamoyl, carboxylType: GrantFiled: May 30, 2006Date of Patent: December 6, 2011Assignee: Jerini AGInventors: Karsten Schnatbaum, Dirk Scharn, Elsa Locardi, Thomas Polakowski, Uwe Richter, Ulrich Reineke, Gerd Hummel
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Publication number: 20110288239Abstract: The present invention discloses a polymeric polyamine which can be produced by polymerizing polyoxyalkylene-amine and a linker. The linker can be anhydride, carboxylic acid, epoxy, isocyanate or poly(styrene-co-maleic anhydride) copolymers (SMA). The present invention also discloses a method for stabilizing the Ag nanoparticles with polymeric polyamine. The polymeric polyamine serving as a stabilizer or dispersant is mixed with a water solution of silver salt and then a reducer is provided to reduce the silver ions and form an organic or a water solution of Ag nanoparticles. Water or solvent of this solution can be further removed through a heating, freezing or decompression process, and thus solid content of the solution can be increased. The concentrated solution also can be diluted to obtain a stable dispersion without aggregation.Type: ApplicationFiled: August 1, 2011Publication date: November 24, 2011Applicant: NATIONAL TAIWAN UNIVERSITYInventors: Jiang-Jen Lin, Wei-Cheng Tsai, Yen-Chi Hsu, Wen-Hsin Chang
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Publication number: 20110198534Abstract: A urea compound of the present invention is represented by general formula (1) shown below. [Each of X1, X2 and X3 independently represents a hydrogen atom, an alkyl group or an aryl group. The aryl group may have one or more functional groups selected from the group consisting of halogen groups, alkyl groups and alkoxy groups.Type: ApplicationFiled: September 15, 2009Publication date: August 18, 2011Applicants: National University Corporation Shizuoka University, Nissan Chemical Industries, Ltd.Inventor: Masamichi Yamanaka
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Publication number: 20110124916Abstract: Provided is a thermal responsive molecule favorable as a thermal responsive low-molecular hydrogelling agent or the like that gels in response to heat. The thermal responsive molecule is characterized in that an amphiphilic side chain obtained by bonding a hydrophilic side chain such as triethylene glycol and a hydrophobic group such as an octyl group is introduced into a C3-symmetric disc-shaped molecular skeleton such as 1,3,5-benzenetriyltriurea. For example, the thermal responsive molecule is 1,1?,1?-(benzene-1,3,5-triyl)tris{3-(2,5,8,11-tetraoxaheptadecan-17-yl)urea} or the like.Type: ApplicationFiled: November 19, 2010Publication date: May 26, 2011Applicant: KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATIONInventors: Noboru Koga, Satoru Karasawa, Hiroyuki Hayashi
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Publication number: 20110039819Abstract: The present invention relates to substituted phenoxybenzamide compounds of general formula (I): in which R1, R2, R3, R4, R5, X, R6 and q are as defined in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.Type: ApplicationFiled: April 9, 2009Publication date: February 17, 2011Inventors: Marion Hitchcock, Ingo Hartung
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Patent number: 7863332Abstract: Novel biaromatic compounds having the general formula (I): and cosmetic/pharmaceutical compositions comprised thereof are useful in human or veterinary medicine (in dermatology and also in the fields of cardiovascular diseases, of immune diseases and/or of diseases related to the metabolism of lipids) or, alternatively, in cosmetic compositions.Type: GrantFiled: February 16, 2007Date of Patent: January 4, 2011Assignee: Galderma Research & DevelopmentInventors: Laurence Clary, Jean-Guy Boiteau, Corinne Millois Barbuis
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Patent number: 7572849Abstract: Disclosed herein are urea phenyl derivatives of the formula: wherein each R is an independently selected hydrocarbyl group and n is 2 or 3, and their use as nucleating agents for propylene polymers.Type: GrantFiled: November 18, 2005Date of Patent: August 11, 2009Assignee: Chemtura CorporationInventors: Qinggao Ma, William A. Wortman, Jin-yun Wang, Huiling Ding, Roy Russell, Leigh C. Allen, Paul E. Stott, John Wefer, David J. Sikora
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Publication number: 20090176095Abstract: In accordance with the present invention, there are provided a triphenylmethane derivative represented by the following general formula (1), an organic gelling agent containing the triphenylmethane derivative, an organic gel and an organic fiber. The triphenylmethane derivatives of the present invention can exhibit a capability of gelling various organic solvents even when used in a small amount notwithstanding these derivatives are low-molecular compounds. The resultant organic gel is useful as materials usable under a high-temperature condition such as chemomechanical system materials, impact and vibration absorbing materials, drug base materials, controlled drug-release materials, and silicone oil gels for solidification of electrolytic solutions and for cosmetics. In addition, an organic nanofiber can be produced from the triphenylmethane derivative by a simple process.Type: ApplicationFiled: January 19, 2005Publication date: July 9, 2009Inventor: Dai Oguro
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Patent number: 7501442Abstract: This invention provides compounds of formula I: wherein a, b, c, m, p, r, R1, R2, R3, R4, R5, R6, W and X1 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.Type: GrantFiled: March 10, 2005Date of Patent: March 10, 2009Assignee: Theravance, Inc.Inventors: Mathai Mammen, Yu-Hua Ji, Craig Husfeld
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Publication number: 20090047435Abstract: One aspect of the invention is a compound of formula (I) Ro-[L-(CqH2qS)pCrH2rRf]2??(I) wherein Ro is a divalent organic group having 2 to 40 carbon atoms; L is a linking group selected from —NHC(O)NH— or —C(O)NH— wherein the left side of the linking group is bonded to Ro; p is an integer of 0 or 1; q is an integer of 2 to 10; r is an integer of 1 to 10; and Rf is a linear or branched C1-C6 perfluoroalkyl group. Another aspect of the invention is a composite material comprising a porous support and a porous nanoweb, wherein said porous nanoweb comprises fibrous structures of between about 10 nm and about 1000 nm effective average fiber diameter as determined with electron microscopy; said fibrous structures being comprised of one or more compositions of formula (I). Another aspect of the invention is a method for making a composite material comprising a porous support and a porous nanoweb.Type: ApplicationFiled: August 13, 2007Publication date: February 19, 2009Inventors: Keith Ward Hutchenson, Anilkumar Raghavanpillai, Stefan Reinartz
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Publication number: 20080306067Abstract: A compound of formula (I), wherein substituents are as given above, useful in the treatment of a disease mediated by the action of CCR3, in particular inflammatory or obstructive airway diseases.Type: ApplicationFiled: October 23, 2006Publication date: December 11, 2008Inventors: Klaus Weigand, Thomas Ullrich, Kate Hoeganauer, Philipp Lehr, Rohan Beckwith
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Publication number: 20080220003Abstract: The present invention is related to a compound, preferably a C5a receptor antagonist, having the following structure, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, R20, R21 and R22 are individually and independently selected from the group comprising H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, arylalkyl, substituted arylalkyl, heteroarylalkyl, substituted heteroarylalkyl, alkoxyl, substituted alkoxyl, aryloxy, substituted aryloxy, arylalkyloxy, substituted arylalkyloxy, acyloxy, substituted acyloxy, halogen, hydroxyl, nitro, cyano, acyl, substituted acyl, mercapto, alkylthio, substituted alkylthio, amino, substituted amino, alkylamino, substituted alkylamino, bisalkyl amino, substituted bisalkyl amino, cyclic amino, substituted cyclic amino, carbamoyl (—CONH2), substituted carbamoyl, carboxylType: ApplicationFiled: May 30, 2006Publication date: September 11, 2008Applicant: Jerini AGInventors: Karsten Schnatbaum, Dirk Scharn, Elsa Locardi, Thomas Polakowski, Uwe Richter, Ulrich Reineke, Gerd Hummel
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Publication number: 20080125424Abstract: The present invention relates generally to compounds represented in Formula I, pharmaceutical compositions comprising them and methods of treating of diseases or disorders related to the function of the calcium sensing receptor. The invention also relates to processes for making such compounds and to intermediates useful in these processes.Type: ApplicationFiled: July 10, 2007Publication date: May 29, 2008Inventors: Pierre DePrez, Sarah E. Lively, Taoues Temal
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Publication number: 20080108672Abstract: This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy.Type: ApplicationFiled: June 25, 2007Publication date: May 8, 2008Inventors: Bernd Riedl, Jacques Dumas, Uday Khire, Timothy B. Lowinger, William J. Scott, Roger A. Smith, Jill E. Wood, Mary-Katherine Monahan, Reina Natero, Joel Renick, Robert N. Sibley
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Publication number: 20080085936Abstract: The invention relates to compounds of formula (I), wherein R, R1, R2, X and n are as defined in the description, and their use for the preparation of pharmaceutical compositions for the treatment of inflammatory states.Type: ApplicationFiled: June 16, 2005Publication date: April 10, 2008Inventors: Pier Giovanni BARALDI, Pier Andrea BOREA, Pierangelo GEPPETTI
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Patent number: 7285568Abstract: Novel biaromatic compounds having the structural formula (I) below: are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine (in dermatology, and also in the fields of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism), or, alternatively, into cosmetic compositions.Type: GrantFiled: May 24, 2005Date of Patent: October 23, 2007Assignee: Galderma Research & DevelopmentInventors: Laurence Clary, Claire Bouix-Peter, Michel Rivier, Pascal Collette, Andre Jomard
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Patent number: 7230133Abstract: The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma, multiple sclerosis, artherosclerosis, and rheumatoid arthritis.Type: GrantFiled: April 29, 2004Date of Patent: June 12, 2007Assignee: Bristol-Myers Squibb CompanyInventor: Percy Carter
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Patent number: 7176222Abstract: The present invention provides intermediates, synthetic methods and novel urea compositions of matter.Type: GrantFiled: January 11, 2005Date of Patent: February 13, 2007Assignee: Cytokinetics, Inc.Inventors: Bradley Paul Morgan, George Petros Yiannikouros, Michael P. Cruskie, Jr., Christopher Roy Goss
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Patent number: 7161034Abstract: Lidocaine analogs, latex particle-analog conjugates, and methods of making and using the same. The analogs have the formula: wherein Z comprises a nucleophilic group and optionally a protecting group; L is a linker; R1, R2, R3, R4, R5 are each independently H, a protecting group, or C1 to C6 alkyls, provided that R1 and R3 may form a six membered ring with the nitrogen and carbon atom to which R1 and R3 are attached; R6 and R7 are each independently H or C1 to C20 alkyls; and including salts thereof. The analogs are immobilized on latex particles and prepared for use in assays for lidocaine.Type: GrantFiled: April 20, 2004Date of Patent: January 9, 2007Assignee: Dade Behring Inc.Inventors: Victor P. Chu, Zhu Teng, Sandra Lewisch, Ronald L. Edwards
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Patent number: 7157601Abstract: Compounds of the formulae wherein Z is —OR1, —SR1, —NR1R2, Y is —OR3, —SR3, or —NR3R4, at least one of R1, R2, R3, R4, R5, and R6 is hydrogen, at least one of R1, R2, R3, R4, R5, and R6 is other than hydrogen, at least one Z or Y within the compound is —NR1R2 or —NR3R4, R1, R2, R3, R4, R5, R6, and R7 each, independently of the others, is hydrogen, alkyl, aryl, arylalkyl, or alkylaryl, and wherein R7 can also be alkoxy, aryloxy, arylalkyloxy, alkylaryloxy, polyalkyleneoxy, polyaryleneoxy, polyarylalkyleneoxy, polyalkylaryleneoxy, silyl, siloxane, polysilylene, polysiloxane, or wherein X is a direct bond, oxygen, sulfur, —NR40— wherein R40 is hydrogen, alkyl, aryl, arylalkyl, alkylaryl, or —CR50R60— wherein R50 and R60 each, independently of the other, is hydrogen, alkyl, aryl, arylalkyl, or alkylaryl.Type: GrantFiled: February 28, 2006Date of Patent: January 2, 2007Assignee: Xerox CorporationInventors: Marcel P. Breton, Danielle C. Boils-Boissier, Jule W. Thomas, Jr., Donald R. Titterington, H. Bruce Goodbrand, Jeffrey H. Banning, James D. Wuest, Dominic Laliberte, Marie-Eve Perron
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Patent number: 7105567Abstract: The present invention relates to a urea derivative of the formula (1) wherein each symbol is as described in the specification, a pharmaceutically acceptable salt thereof and pharmaceutical use thereof. The compound of the present invention has a C5a receptor antagonistic action and is useful as an agent for the prophylaxis or treatment of diseases or syndromes due to inflammation caused by C5a [e.g., autoimmune diseases such as rheumatism, systemic lupus erythematosus and the like, sepsis, adult respiratory distress syndrome, chronic obstructive pulmonary disease, allergic diseases such as asthma and the like, atherosclerosis, cardiac infarction, brain infarction, psoriasis, Alzheimer's disease and serious organ injury (e.g., pneumonia, nephritis, hepatitis, pancreatitis and the like) due to activation of leukocytes caused by ischemia, trauma, burn, surgical invasion and the like].Type: GrantFiled: August 10, 2001Date of Patent: September 12, 2006Assignee: Mitsubishi Pharma CorporationInventors: Seigo Ishibuchi, Hiroshi Sumichika, Katsuhiko Itoh, Yoichi Naka
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Patent number: 7087752Abstract: Compounds of the formulae wherein Z is OR1, SR1, or NR1R2, Y is OR3, SR3, or NR3R4, at least one of R1, R2, R3, R4, R5, and R6 is hydrogen, at least one of R1, R2, R3, R4, R5, and R6 is other than hydrogen, at least one Z or Y within the compound is NR1R2 or —NR3R4, R1, R2, R3, R4, R5, R6, and R7 each, independently of the others, is hydrogen, alkyl, aryl, arylalkyl, or alkylaryl, and wherein R7 can also be (vi) an alkoxy, aryloxy, arylalkyloxy, alkylaryloxy, polyalkyleneoxy, polyaryleneoxy, polyarylalkyleneoxy, polyalkylaryleneoxy, silyl, siloxane, polysilylene, polysiloxane, or wherein X is a direct bond, oxygen, sulfur, NR40— wherein R40 is hydrogen, alkyl, aryl, arylalkyl, or alkylaryl, or CR50R60— wherein R50 and R60 each, independently of the other, is hydrogen, alkyl, aryl, arylalkyl, or alkylaryl, and wherein R6 can also beType: GrantFiled: March 26, 2004Date of Patent: August 8, 2006Assignee: Xerox CorporationInventors: Marcel P. Breton, Danielle C. Boils-Boissier, Jule W. Thomas, Jr., Donald R. Titterington, H. Bruce Goodbrand, Jeffrey H. Banning, James D. Wuest, Dominic Laliberte, Marie-Eve Perron
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Patent number: 7064229Abstract: The present invention relates to compounds of the general formula (I), processes for their preparation, pharmaceutical compositions containing them as well as their use for the production of pharmaceutical compositions for the treatment of inflammatory diseasesType: GrantFiled: June 24, 2002Date of Patent: June 20, 2006Assignee: Bayer Healthcare AGInventors: Thomas Rolle, Thomas Lehmann, Markus Albers, Gerhard Muller, Gerhard Hessler, Rudiger Fischer, Masaomi Tajimi, Karl Ziegelbauer, Kevin Bacon, Haruki Hasegawa, Hiromi Okigami
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Patent number: 7034056Abstract: In one embodiment, this invention provides a novel class of compounds as antagonists of the MCH receptor, methods of preparing such compounds, pharmaceutical compositions containing one or more of the compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention or amelioration or one or more of diseases associated with the MCH receptor.Type: GrantFiled: March 19, 2002Date of Patent: April 25, 2006Assignee: Pharmacopeia Drug Discovery, inc.Inventors: Douglas Walsh Hobbs, Tao Guo, Rachael C. Hunter, Huizhong Gu
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Patent number: 7030261Abstract: Disclosed is a method for preparing a 2-hydroxy-6-ureidocarbonyl naphthalene derivative. The method comprises the step of reacting 2-hydroxy-6-aminocarbonyl naphthalene and a isocyanate in an organic solvent at a temperature of 90–200° C. According to the present invention, 2-hydroxy-6-ureidocarbonyl naphthalene derivative can easily be obtained within relatively short time and high yield.Type: GrantFiled: February 3, 2005Date of Patent: April 18, 2006Assignee: Kabushiki Kaisha Ueno Seiyaku Oyo KenkyujoInventors: Masaya Kitayama, Hiroyuki Wakamori, Nobuhiro Yonetani
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Patent number: 7026357Abstract: Compound of formula (I): and medicinal products containing the same are useful as dual ?2/5-HT2c antagonist receptors.Type: GrantFiled: June 7, 2004Date of Patent: April 11, 2006Assignee: Les Laboratoires ServierInventors: Gilbert Lavielle, Olivier Muller, Mark Millan, Anne Dekeyne, Mauricette Brocco
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Patent number: 6962945Abstract: The present invention provides N-aryloxypropanolyl-N?-phenethyl-urea derivatives of formula 3, method for their preparation and use thereof as potent appetite suppressants for treatment of obesity wherein R is selected from the group consisting of H, 2, 3 or 4-trifluoromethyl, 2, 3, or 4-chloro, 2, 3, or 4-bromo, 4-acetyl, 4-propionyl, 4-acetamido, 2,3 or 4 methoxy, 4 nitrile, 2,3 or 4-methyl, and 4 formyl and X is S or O.Type: GrantFiled: March 26, 2004Date of Patent: November 8, 2005Assignee: Council of Scientific and Industrial ResearchInventors: Kalpana Bhandari, Shipra Srivastava, Chandeshwar Nath
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Patent number: 6949567Abstract: The invention relates to new diphenylurea having the formula (I) or a salt thereof, where Y is C?O, C?S, C?NH, (C?O)2 or SO2; and to processes for the preparation of these compounds and to their use in the treatment of protozoal diseases and to diseases where the inhibition of intracellular protein-degradation pathways is of benefit.Type: GrantFiled: February 26, 2002Date of Patent: September 27, 2005Assignee: 4SC AGInventors: Andrea Aschenbrenner, Katharina Aulinger Fuchs, Matthias Dormeyer, Gabriel Garcia, Bernd Kramer, Jürgen Kraus, Rolf Krauss, Johan Leban, Stefano Pegoraro, Wael Saeb, Kristina Wolf
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Patent number: 6927271Abstract: Coating compositions contain hydroxyl- or carbamate functional resins with a relatively low equivalent weight. The resins are based on a polyol core containing urea and hydroxyl groups, and made by reacting a polyisocyanate, preferably a triisocyanate, with an amino functional polyol, preferably a polyol having one amino group and two or more hydroxyl groups. The polyol core may be further extended to a first or higher generation dendrimer or hyperbranched structure by reacting the initial polyol core with a compound having one carboxyl group and two or more hydroxyl groups.Type: GrantFiled: January 10, 2002Date of Patent: August 9, 2005Assignee: BASF CorporationInventor: Sunitha Grandhee
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Patent number: 6911457Abstract: The present invention relates to novel imaging probes and methods for using the probes in diagnostic imaging processes and other imaging processes to determine physiological functions.Type: GrantFiled: April 11, 2003Date of Patent: June 28, 2005Assignee: Carbomer, Inc.Inventor: Manssur Yalpani