Plural Hydroxys In The Same Substituent On The Amino Nitrogen (h Of -oh May Be Replaced By A Substituted Or Unsubstituted Ammonium Ion Or A Group Ia Or Iia Light Metal) Patents (Class 564/507)
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Patent number: 11718636Abstract: There are provided compounds of Formula (A) and pharmaceutically acceptable salts and esters thereof, and pharmaceutical compositions thereof, used for the prevention or treatment in a mammal of joint and bone disorders such as arthritis and osteoporosis.Type: GrantFiled: December 17, 2018Date of Patent: August 8, 2023Assignee: RISEN (SUZHOU) PHARMA TECH CO., LTD.Inventors: Xianqi Kong, Jiasheng Lu, Jiamin Gu, Xiang Ji, Daiqiang Hu, Xiuchun Zhang, Xinyong Lv, Jinchao Ai, Dongdong Wu, Lin Wang, Dongqing Zhu, Xiaolin He
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Patent number: 11696879Abstract: Dental pastes are provided which include: (i) a compound of Formula (I), (ii) a compound of Formula (II) or a pharmaceutically acceptable salt thereof, and (iii) a dental abrasive.Type: GrantFiled: May 22, 2017Date of Patent: July 11, 2023Assignee: 3M INNOVATIVE PROPERTIES COMPANYInventors: Jie Yang, Richard P. Rusin, Petra L. Kohler Riedi, Joel D. Oxman, Jodi L. Connell
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Publication number: 20150073003Abstract: The present invention provides new ceramide analogs indicated as the compounds of formula (II). These novel analogs exhibit a significant anti cancerous effect and are therefore provided as a pharmaceutical composition for treating cell proliferative diseases, neurodegenerative disorders, metabolism-associated conditions, infectious diseases, and immune-related disorders. The invention further provides combined compositions and kits combining the novel ceramide analogs of formula (II) with an additional therapeutic agent.Type: ApplicationFiled: November 13, 2014Publication date: March 12, 2015Inventors: Arie DAGAN, Shimon SLAVIN, Shimon GATT, Jeremy ZAHAVY
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Patent number: 8968709Abstract: Dental compositions are provided comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof: wherein n is an integer from about 2 to about 5.Type: GrantFiled: July 10, 2008Date of Patent: March 3, 2015Assignee: 3M Innovative Properties CompanyInventors: Jie Yang, Bhaskar V. Velamakanni, Sumita B Mitra, Alphonsus V. Pocius, John J. Stofko, Jr., Jeremy M. Yarwood
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Publication number: 20150005471Abstract: Provided are methods and compositions which are useful for separating, isolating, detecting, and quantifying compounds of interest which have been modified chemically, enzymatically or catalytically from other compounds which have not been so modified. The modifications may take the form of functional groups which are gained, lost or retained by the compounds of interest.Type: ApplicationFiled: June 5, 2014Publication date: January 1, 2015Applicant: ENZO LIFE SCIENCES, INC. C/O ENZO BIOCHEM, INC.Inventors: ELAZAR RABBANI, JOSHUA RABBANI, PRAVEEN PANDE, JANNIS G. STAVRIANOPOULOS
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Patent number: 8901355Abstract: Provided are new dendrimers and processes for making them. The dendrimers are derived from a nitroalkyloxirane compound of formula (III): wherein R1, R2, and R3 are as described herein.Type: GrantFiled: May 17, 2012Date of Patent: December 2, 2014Assignees: Dow Global Technologies LLC, ANGUS Chemical CompanyInventors: Ian A. Tomlinson, Asghar A. Peera
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Patent number: 8889814Abstract: The object of the invention are compounds of the formula (2) wherein R1 is H, methyl or ethyl, R2 is C1- to C4 alkyl, A is a C2- to C4 alkylene group, m is number from 10 to 400, n is 1, 2, 3, 4, or 5, a method for their production and their use in the production of polyurethane prepolymers.Type: GrantFiled: August 27, 2013Date of Patent: November 18, 2014Assignee: Clariant Finance (BVI) LimitedInventors: Klaus Poellmann, Juergen Muenter
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Publication number: 20140235776Abstract: Provided are aminoalcohol compounds for use as additives in paints and coatings. The compounds are of the formula I: wherein p, m, n, R, R1, R2, R3, R4, R5, and R6 are as defined herein.Type: ApplicationFiled: July 23, 2012Publication date: August 21, 2014Applicants: ANGUS CHEMICAL COMPANY, DOW GLOBAL TECHNOLOGIES LLCInventors: Asghar Peera, Raymond J. Swedo, G. David Green, Esin G. Busche, John W. Quinn, Shreyas Bhide, Mahesh Sawant
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Publication number: 20140235789Abstract: The present application discloses peptides and peptaibols of high purity may be obtained by solid phase peptide synthesis using as the starting resin hydroxy amino acids, hydroxy amino acid amides, hydroxy amino alcohols or small peptides containing hydroxy amino acids attached to polymers through their side chain.Type: ApplicationFiled: February 21, 2013Publication date: August 21, 2014Applicant: Chemical & Biopharmaceutical Laboratories of Patras S.A.Inventor: Chemical & Biopharmaceutical Laboratories of Patras S.A.
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Publication number: 20140187820Abstract: Provided are polyhydroxy-diamine compounds of the formula I: or salt thereof, wherein R1, R2, and R3 are as defined herein. The compounds are useful as low additives for paints, coatings and epoxy formulations.Type: ApplicationFiled: March 5, 2014Publication date: July 3, 2014Applicants: Angus Chemical Company, Dow Global Technologies LLCInventors: Ian A. Tomlinson, Asghar A. Peera
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Publication number: 20140170067Abstract: The present invention relates to novel compounds of formulae (I) and (II) which are useful in the prevention, treatment and diagnosis, in vivo diagnosis of diseases or disorders related to S1P receptors, in particular, in diseases which are connected to the regulatory function of sphingosine-1-phosphate (S1P) and its analogues, such as inflammation, pain, autoimmune diseases and cardiovascular diseases.Type: ApplicationFiled: August 16, 2012Publication date: June 19, 2014Applicant: WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTERInventors: Guenter Haufe, Bodo Levkau, Michael Schaefers, Stefani Silke Schilson, Petra Keul
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Publication number: 20140131258Abstract: A method for removing oil from a physical object comprises the steps: i) bringing said physical object in contact with an oil removal composition, said oil removal composition comprising a) a surfactant having the general formula: R1-X—R2, wherein R1 is an open chain sugar alcohol, wherein X is one selected from NH, NCH3 and NCH2CH3, and wherein R2 is an aliphatic or aromatic group comprising at least 5 carbon atoms, and b) water, ii) leaving said oil removal composition in contact with said physical object for a period of time sufficient for most of said oil to be dispersed in said oil removal composition, High recovery of oil/bitumen from tar sands can be achieved. The composition is renewable, degradable and inexpensive. An extremely efficient de-greater is provided. The composition used in both bitumen recovery and degreasing is easily reusable and recycleable. The starting materials of the surfactant are renewable and inexpensive. The composition is non-toxic and biodegradable.Type: ApplicationFiled: April 25, 2012Publication date: May 15, 2014Applicant: ORGANOPETROLEUM PSP ABInventor: Peter Piispanen
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Publication number: 20140130714Abstract: Provided are aminoalcohol compounds for use as additives for paints and coatings. The compounds are of the formula (I): wherein x, R, R1, R2, R3, R4, R5, R6, and RA are as defined herein.Type: ApplicationFiled: July 23, 2012Publication date: May 15, 2014Applicants: ANGUS CHEMICAL COMPANY, DOW GLOBAL TECHNOLOGIES LLCInventors: Asghar Peera, Raymond J. Swedo, G. David Green, Esin G. Busche, John W. Quinn, Shreyas Bhide, Mahesh Sawant
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Publication number: 20140107376Abstract: Provided are new dendrimers and processes for making them. The dendrimers are derived from a nitroalkyloxirane compound of formula (III): wherein R1, R2, and R3 are as described herein.Type: ApplicationFiled: May 17, 2012Publication date: April 17, 2014Applicants: ANGUS CHEMICAL COMPANY, DOW GLOBAL TECHNOLOGIES LLCInventors: Ian A. Tomlinson, Asghar A. Peera
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Patent number: 8680338Abstract: A method for adjusting pH in an aqueous coating composition having an initial pH less than 7 by adding to the aqueous coating composition a compound having formula (V) wherein R2 and R3 independently are hydrogen, methyl, ethyl, hydroxymethyl, or R2 and R3 combine with a carbon to which they are attached to form a five-membered or six-membered saturated carbocyclic ring; R4 is hydrogen or C1-C4 alkyl; R5 is hydrogen, methyl, ethyl or hydroxymethyl; R6 is hydrogen, hydroxyethyl, C1-C10 alkyl or —CH2C(R5)(N(R7)2)CH2OH; and R7 is hydrogen or methyl.Type: GrantFiled: September 25, 2013Date of Patent: March 25, 2014Assignee: ANGUS Chemical CompanyInventors: Ian A. Tomlinson, Asghar A. Peera
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Patent number: 8647608Abstract: Dental compositions are provided comprising a compound of Formula I or a pharmaceutically acceptable salt thereof: wherein n is an integer from about 2 to about 5.Type: GrantFiled: October 31, 2012Date of Patent: February 11, 2014Assignee: 3M Innovative Properties CompanyInventors: Jie Yang, Bhaskar V. Velamakanni, Sumita B. Mitra, Alphonsus V. Pocius, John J. Stofko, Jr., Jeremy M. Yarwood
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Patent number: 8586065Abstract: The present invention relates to an oil-in-water emulsified cosmetic composition, which contains an emulsion having (A) a sphingosine represented by formula (1), (B) an acid compound selected from inorganic acids and organic acids having 5 or less carbon atoms, and (C) a ceramide represented by formula (2); and another emulsion having (D) an oil component selected from polar oils and hydrocarbon oils, and (E) a surfactant. The oil-in-water emulsified cosmetic composition contains a ceramide and is excellent in emulsion stability.Type: GrantFiled: August 17, 2010Date of Patent: November 19, 2013Assignee: Kao CorporationInventor: Yumiko Yamamoto
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Patent number: 8575396Abstract: A method for producing a polyamino-polyalcohol. The method comprises steps of: (a) combining an aminoalcohol of formula (I) with a nitro-diol of formula (II) to produce a nitro amino diol; and (b) contacting the nitro amino diol with a reducing agent capable of reducing aliphatic nitro groups.Type: GrantFiled: December 12, 2011Date of Patent: November 5, 2013Assignees: Angus Chemical Company, Dow Global Technologies LLCInventors: Ian A. Tomlinson, Asghar A. Peera
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Patent number: 8546616Abstract: The object of the invention are compounds of the formula (2) wherein R1 is H, methyl or ethyl, R2 is C1- to C4 alkyl, A is a C2- to C4 alkylene group, m is number from 10 to 400, n is 1, 2, 3, 4, or 5, a method for their production and their use in the production of polyurethane prepolymers.Type: GrantFiled: June 13, 2007Date of Patent: October 1, 2013Assignee: Clariant Finance (BVI) LimitedInventors: Klaus Poellmann, Juergen Muenter
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Publication number: 20130217691Abstract: A method of treating a hyperproliferative disorder in a subject in need of such treatment, comprising administering to said subject, in combination, a treatment effective amount of: (a) a ceramide-increasing retinoid such as fenretinide or a pharmaceutically acceptable salt thereof; and (b) at least one (and in certain embodiments at least two) compounds selected from the groups consisting of (i) a non-18 carbon chain length L-threo-sphinganine(s) or pharmaceuticeutically acceptable salt thereof, (ii) glucosylceramide or glucosyl(dihydro)ceramide synthesis inhibitor(s), and (iii) sphingomyelin or dihydrosphingomyelin synthase inhibitor(s). Preferred L-threo-sphinganines are of carbon chain length 17 carbons, 19 carbons and 20 carbons. A preferred glucosylceramide or glucosyl(dihydro)ceramide synthesis inhibitor is D-threo-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol. A preferred sphingomyelin or dihydrosphingomyelin synthesis inhibitor is D-threo-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol.Type: ApplicationFiled: April 3, 2013Publication date: August 22, 2013Applicant: Texas Tech University SystemInventor: Texas Tech University System
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Publication number: 20130052146Abstract: Dental compositions are provided comprising a compound of Formula I or a pharmaceutically acceptable salt thereof: wherein n is an integer from about 2 to about 5.Type: ApplicationFiled: October 31, 2012Publication date: February 28, 2013Applicant: 3M INNOVATIVE PROPERTIES COMPANYInventor: 3M Innovative Properties Company
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Publication number: 20120329737Abstract: The invention relates to hybrid molecules made of two lipids or lipid-analogous compounds which are linked to each other via their lipophilic end. The hybrid molecules thereby have at least one hydrophilic group at their hydrophilic end for increasing the hydration shell of the hybrid molecule. The hybrid molecules according to the invention can be used as pharmaceutical or as a cosmetic preparation.Type: ApplicationFiled: June 23, 2010Publication date: December 27, 2012Inventor: Hans-Uwe Wolf
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Patent number: 8334402Abstract: Amines and amine derivatives that improve the buffering range, and/or reduce the chelation and other negative interactions of the buffer and the system to be buffered. The reaction of amines or polyamines with various molecules to form polyamines with differing pKa's will extend the buffering range, derivatives that result in polyamines that have the same pKa yields a greater buffering capacity. Derivatives that result in zwitterionic buffers improve yield by allowing a greater range of stability.Type: GrantFiled: October 6, 2010Date of Patent: December 18, 2012Inventor: Thomas Daly
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Publication number: 20120316359Abstract: Amines and amine derivatives that improve the buffering range, and/or reduce the chelation and other negative interactions of the buffer and the system to be buffered. The reaction of amines or polyamines with various molecules to form polyamines with differing pKa's will extend the buffering range, derivatives that result in polyamines that have the same pKa yields a greater buffering capacity. Derivatives that result in zwitterionic buffers improve yield by allowing a greater range of stability.Type: ApplicationFiled: August 17, 2012Publication date: December 13, 2012Inventor: Thomas Daly
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Publication number: 20120277471Abstract: A synthesis method of 3-methylamino-1,2-propanediol is disclosed in the invention, and it includes the following steps: (1) adding glycerin chlorohydrin, aqueous monomethylamine solution and an amination catalyst, namely NaOH solution and NaHCO3, into a reactor, mixing the material sufficiently, and allowing amination reaction to proceed in two temperature stages; (2) removing monomethylamine and water from the amination solution after the amination reaction is completed, filtering out the solid resultant, and feeding the filtrate into a still; (3) distilling under reduced pressure to obtain 3-methylamino-1,2-propanediol, wherein the vacuum for distillation under reduced pressure is equal to or greater than 0.099 MPa and the temperature is 130-160° C. The product synthesized according to the invention, a liquid appearing colorless and transparent, has increased purity of over 99.5% (GC) and decreased impurities.Type: ApplicationFiled: March 12, 2010Publication date: November 1, 2012Applicant: Weifang PBNS Chem Industry Co. LtdInventors: Zhongfa Zhang, Xueyang Guo, Hui Huang
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Patent number: 8211945Abstract: Methods for stabilizing ?-galactosidase, stabilizing ?-glucocerebrosidase, treating a glycolipid metabolic disorder caused by mutation of ?-galactosidase gene, treating a glycolipid metabolic disorder caused by mutation of ?-glucocerebrosidase gene, regenerating the activity of ?-galactosidase, regenerating the activity of ?-glucosidase, treating GM1 gangliosidosis, Morquio-B or Krabbe's disease, and treating Gaucher's disease, include administering a carba-sugar amine derivative represented by the following formula (1) or (2):Type: GrantFiled: June 24, 2009Date of Patent: July 3, 2012Assignee: Seikagaku CorporationInventors: Seiichiro Ogawa, Yoshiyuki Suzuki, Eiji Nanba, Junichiro Matsuda, Kousaku Ohno
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Patent number: 8158827Abstract: Disclosed are cationic lipid compounds and compositions of lipid aggregates for delivery of macromolecules and other compounds into cells. The compounds can be used alone or in combination with other compounds to prepare liposomes and other lipid aggregates suitable for transfection or delivery of compounds to target cells, either in vitro or in vivo. The compounds are preferably polycationic and preferably form highly stable complexes with various anionic macromolecules, particularly polyanions such as nucleic acids. These compounds have the property, when dispersed in water, of forming lipid aggregates which associate strongly, via their cationic portion, with polyanions. Also disclosed are intermediates for preparing the compound and compositions of the invention and methods of using the compounds to introduce other compounds into cells.Type: GrantFiled: January 14, 2009Date of Patent: April 17, 2012Assignee: Life Technologies CorporationInventors: Yongliang Chu, Malek Masoud, Gulilat Gebeyehu
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Publication number: 20120053134Abstract: The present invention relates to a pharmaceutical composition for preventing or treating neuronal damage and neurological diseases, and more particularly, to a pharmaceutical composition for preventing or treating neuronal damage and neurological diseases containing, as active ingredients, any one or two or more compounds selected from a group consisting of the compound of chemical formula 1, the compound of chemical formula 2, and the acceptable salts thereof. The pharmaceutical composition repairs nerve tissue damaged by herpes zoster to reduce the acute pain caused by herpes zoster, prevents postherpetic neuralgia, and enables a fundamental treatment through the recovery of nerve tissue in the postherpetic neuralgia.Type: ApplicationFiled: May 6, 2010Publication date: March 1, 2012Inventors: Jae-Hoon Jung, Hyung-Ryong Moon
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Publication number: 20120035298Abstract: Provided are polyhydroxy-diamine compounds of the formula I: or salt thereof, wherein R1, R2, and R3 are as defined herein. The compounds are useful as low additives for paints, coatings and epoxy formulations.Type: ApplicationFiled: April 28, 2010Publication date: February 9, 2012Inventors: Ian A. Tomlinson, Asghar A. Peera
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Publication number: 20110282081Abstract: Novel methods of synthesizing 1-deoxy-sphingoid bases and derivatives are disclosed. The synthesis is achieved from commercially available and inexpensive starting materials. The process includes thioesterification, cross-coupling, and reduction. The process may also include directed epoxidation, regioselective epoxide-opening, hydrogenation, and dihydroxylation. The methods described herein provide 1-deoxy-sphingoid bases and derivatives in high overall yield and high enantiomeric purity.Type: ApplicationFiled: January 21, 2010Publication date: November 17, 2011Applicant: EMORY UNIVERSITYInventors: Lanny S. Liebeskind, Ethel C. Garnier-Amblard, Dennis C. Liotta
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Publication number: 20110251289Abstract: The invention provides a method of preparing the stereoisomers of 1,11-diamino-6-aza-undecane-2,4,8,10-tetraol.Type: ApplicationFiled: June 3, 2009Publication date: October 13, 2011Applicants: CSIR, AGRICULTURAL RESEARCH COUNCIL, UNIVERSITY OF PRETORIAInventors: Moira Bode, Robert Vleggaar, Paul J. Gates, R. Anitra Schultz, Dharmaral Naicker, Nel Fourie
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Publication number: 20110137076Abstract: Amines and amine derivatives that improve the buffering range, and/or reduce the chelation and other negative interactions of the buffer and the system to be buffered. The reaction of amines or polyamines with various molecules to form polyamines with differing pKa's will extend the buffering range, derivatives that result in polyamines that have the same pKa yields a greater buffering capacity. Derivatives that result in zwitterionic buffers improve yield by allowing a greater range of stability.Type: ApplicationFiled: October 6, 2010Publication date: June 9, 2011Inventor: Thomas Daly
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Patent number: 7939589Abstract: Provided are polyhydroxy-diamine compounds for use as neutralizing agents for paints and coatings. The compounds are of the formula (I): wherein R1 and R2 are as defined herein.Type: GrantFiled: June 17, 2010Date of Patent: May 10, 2011Assignee: Angus Chemical CompanyInventors: Raymond J. Swedo, Esin Busche, John W. Quinn
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Patent number: 7871602Abstract: The use of bis-amines to enhance the antimicrobial activity of pharmaceutical compositions is described. The bis-amines are particularly useful for enhancing the antimicrobial activity of aqueous ophthalmic compositions, such as artificial tears or ocular lubricants, and solutions for disinfecting contact lenses.Type: GrantFiled: October 3, 2008Date of Patent: January 18, 2011Assignee: Alcon, Inc.Inventors: Nissanke L. Dassanayake, Thomas Christopher Carey, Ronald L. Schlitzer, David L. Meadows
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Publication number: 20100326320Abstract: Provided are polyhydroxy-diamine compounds for use as neutralizing agents for paints and coatings. The compounds are of the formula (I): wherein R1 and R2 are as defined herein.Type: ApplicationFiled: June 17, 2010Publication date: December 30, 2010Inventors: Raymond J. Swedo, Esin G. Busche, John W. Quinn
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Patent number: 7851655Abstract: A composition and method for inhibiting white rust formation on galvanized surfaces. The composition includes hydroxyl-substituted monoamines and polyamines, imino derivatives, and hydroxyamine derivatives. The composition may be introduced onto the galvanized surface, especially in an industrial water system, using a variety of different methods or programs including integrating with current programs or developing a new program.Type: GrantFiled: December 19, 2006Date of Patent: December 14, 2010Assignee: Nalco CompanyInventor: Srikanth S. Kidambi
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Publication number: 20100239707Abstract: The present methods and compounds relate to increasing meat tenderness by inducing post-mortem breakdown in muscle tissue. This is achieved by the use of beta-blockers in the pre-mortem period, which results in higher calpastatin levels, and reduced hyperplasia. This is also achieved by the use of agents immediately before slaughter that induce apoptosis in muscle tissue. This is further achieved by administering agents that induce muscle fiber fission.Type: ApplicationFiled: October 9, 2008Publication date: September 23, 2010Inventors: David Goldberg, Keith E. Belk, Phillip D. Bass, Hyungchul Han, Joseph D. Tatum, Gary L. Mason
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Patent number: 7795374Abstract: A method of making antimicrobial quaternary ammonium polymers, comprising: a) mixing 1,4-bis-dimethylamino-2-butene, water, a first portion of triethanolamine and a first portion of acid; b) adding a 1,4-dihalo-2-butene and heating the reaction mixture; c) adding a second portion of triethanolamine and a second portion of acid, and d) isolating a quaternary ammonium polymer having a molecular weight of at least 26 k.Type: GrantFiled: April 23, 2009Date of Patent: September 14, 2010Assignee: Abbott Medical Optics Inc.Inventor: Zhi-Jian Yu
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Publication number: 20100227931Abstract: The present invention provides the antifungal composition, containing the compound (a) selected from specific quaternary ammonium salts and specific amine oxides and the sequestering agent (b) having a calcium-chelating constant of 4 to 12 at a mass ratio (a)/(b) of 0.01 to 10.Type: ApplicationFiled: October 23, 2008Publication date: September 9, 2010Applicant: Kao CorporationInventors: Youichi Kuwano, Akira Ishikawa, Atsushi Tanaka
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Patent number: 7790773Abstract: A carba-sugar amine derivative represented by the following formula (1) or (2) is used as the active ingredient of a ?-galactosidase inhibitor or a glycolipid metabolic disorder treating agent. Wherein each of R1 and R2 independently represents H, an alkyl group, an acyl group, an aryl group or an aralkyl group, with the proviso that both are not H at the same time, and each of R3, R4, R5 and R6 independently represents a hydroxyl group or hydroxyl group having a substituent. Also, R7 represents an alkyl group, and each of R8, R9, R10 and R11 independently represents a hydroxyl group or a hydroxyl group having a substituent.Type: GrantFiled: March 8, 2004Date of Patent: September 7, 2010Assignee: Seikagaku CorporationInventors: Seiichiro Ogawa, Yoshiyuki Suzuki, Eiji Nanba, Junichiro Matsuda, Kousaku Ohno
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Publication number: 20100204519Abstract: An object of the present invention is to provide an aliphatic amine alkylene oxide adduct which has a satisfactory color when used as a detergent, has a sufficiently sharp molecular weight distribution, and is highly pure and less odorous. The present invention is an aliphatic amine alkylene oxide adduct formed by adding m pieces of (A1O) and n pieces of (A2O) [wherein A1O and A2O each independently represent an oxyethylene group and/or an oxypropylene group] to an ethylene oxide 2-mole adduct of a primary amine having a saturated or unsaturated hydrocarbon group having 4 to 24 carbon atoms, the aliphatic amine alkylene oxide adduct having a color which, as expressed by the Gardner color scale, satisfies the following expression (1) or (2): In the case where 1?m+n?15 Gardner color scale?0.5×(m+n+2)?1.Type: ApplicationFiled: September 18, 2008Publication date: August 12, 2010Applicant: SANYO CHEMICAL INDUSTRIES, LTD.Inventor: Seiji Yamashita
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Publication number: 20100150847Abstract: Dental compositions are provided comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof: wherein n is an integer from about 2 to about 5.Type: ApplicationFiled: July 10, 2008Publication date: June 17, 2010Applicant: 3M INNOVATIVE PROPERTIES COMPANYInventors: Jie Yang, Bhaskar V. Velamakanni, Sumita B. Mitra, Alphonsus V. Pocius, John J. Stofko, JR., Jeremy M. Yarwood
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Patent number: 7705112Abstract: The present embodiments relate to a novel method of making quaternary ammonium polymers comprising the steps of: a) mixing 1,4-bis-dimethylamino-2-butene, triethanolamine, water and an acid; and b) introducing a 1,4-dihalo-2-butene to the mixture so as to initiate a reaction resulting in the quaternary ammonium polymer.Type: GrantFiled: April 17, 2007Date of Patent: April 27, 2010Assignee: Abbott Medical Optics Inc.Inventor: Zhi Jian Yu
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Patent number: 7638650Abstract: A compound of formula (I): wherein k is 1 or 2; Y is —CH2CH(CF3)2 or —(CH2)nCF; X is hydrogen, —(CH2)nRf, or —C(O)[CF(A)]p-B—Rf, wherein B is a covalent bond, —O— or —(CH2)m—; A is —F or —CF3; and each Rf is independently C1 to C6 perfluorinated alkyl, optionally interrupted by one or more oxygens; Ro is Ro1 or is an alkyl having from about 10 to about 100 carbon atoms, interrupted or substituted by one or more hydrophilic groups; R is hydrogen or a C1 to C4 alkyl; and Ro1 is an aliphatic group of from about 10 to about 100 carbon atoms, interrupted by about from about 5 to about 50 ether oxygens; provided that 1) when Y is —(CH2)nRf, Ro is Ro1; 2) when X is hydrogen, Y is —CH2CH(CF3)2; and 3) when X is —(CH2)nRf and Y is —(CH2)nRf, Ro is Ro1.Type: GrantFiled: August 6, 2007Date of Patent: December 29, 2009Assignee: E.I. du Pont de Nemours and CompanyInventor: Weiming Qiu
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Patent number: 7635791Abstract: Amines and amine derivatives that improve the buffering range, and/or reduce the chelation and other negative interactions of the buffer and the system to be buffered. The reaction of amines or polyamines with various molecules to form polyamines with differing pKa's will extend the buffering range, derivatives that result in polyamines that have the same pKa yields a greater buffering capacity. Derivatives that result in zwitterionic buffers improve yield by allowing a greater range of stability.Type: GrantFiled: May 9, 2008Date of Patent: December 22, 2009Assignee: TPAT IP LLCInventor: Thomas Daly
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Publication number: 20090286674Abstract: A process for the preparation of active surfaces terminated by a desired form of organic, organic-inorganic, or inorganic nature comprising growing with a gas phase deposition technique preferable the ALCVD (atomic layer chemical vapour deposition) technique. As an example, trimethylaluminium (TMA), hydroquinone (Hq) and phloroglucinol (Phl) have been used as precursors to fabricate surfaces that are terminated by hydroxyl groups attached to aromates. Further types of active surfaces are described. These surfaces can be used to produce surfaces: suitable for adhesion through the use of glue or other adhesive, providing receptors for biological molecules, making the surfaces biocompatible, of catalytically active materials, where upon subsequent types of chemical reactions can take place, with different degrees of wetting properties.Type: ApplicationFiled: June 19, 2007Publication date: November 19, 2009Applicant: UNIVERSITETET I OSLOInventors: Helmer Fjellvag, Ola Nilsen
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Patent number: 7601872Abstract: Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the group consisting of N, O and S; L is any bivalent organic radical capable of linking each Q, such as C, CH, (CH2)l, or {(CH2)i-Y—(CH2)j}k, wherein Y is selected from the group consisting of CH2, an ether, a polyether, an amide, a polyamide, an ester, a sulfide, a urea, a thiourea, a guanidyl, a carbamoyl, a carbonate, a phosphate, a sulfate, a sulfoxide, an imine, a carbonyl, and a secondary amino group and wherein Y is optionally substituted by —X1-L?-X2-Z or -Z; R1-R6, independently of one another, are selected from the group consisting of H, —(CH2)p-D-Z, an alkyl, an alkenyl, an aryl, and an alkyl or alkyl ether optionally substituted by one or more of an alcohol, an aminoalcohol, an amine, an amide, an ether, a polyether, a polyamide, an ester, a mercaptan, an alkylthio, a urea, a thiourea, a guanidyl, or a carbamoyl group, and wType: GrantFiled: January 21, 2005Date of Patent: October 13, 2009Assignee: Life Technologies CorporationInventors: Yongliang Chu, Malek Masoud, Gulilat Gebeyehu
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Patent number: 7531693Abstract: Cationic lipid compositions are provided that are useful for efficient delivery of macromolecules, such as nucleic acids, into a wide variety of eukaryotic cell types. Methods for using the compositions also are provided.Type: GrantFiled: May 24, 2004Date of Patent: May 12, 2009Assignee: Molecular Transfer, Inc.Inventors: Gulilat Gebeyehu, Taysir M. Jaouni, Joel Jessee
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Publication number: 20090117097Abstract: An objective of the present invention is to provide methods for stabilizing proteins and methods for suppressing protein aggregation, which comprise the step of adding for suppressing protein aggregation, which comprise meglumine. Still another objective of the present invention is to provide pharmaceutical compositions comprising antibody molecules stabilized by meglumine, methods for producing the pharmaceutical compositions, and kits comprising the pharmaceutical compositions. To achieve the objectives described above, the present inventors assessed the antibody-stabilizing effect of meglumine, an amino sugar. As a result, the inventors discovered that meglumine was useful as a stabilizer for antibody molecules and also as an excipient for freeze-dried preparations.Type: ApplicationFiled: June 9, 2006Publication date: May 7, 2009Applicant: Chugai Seiyaku Kabushiki KaishaInventors: Tomoyuki Igawa, Daisuke Kameoka
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Patent number: 7524887Abstract: The present invention relates to a method for the prophylaxis or treatment of pain using compounds of formula I, in which R, R2, R3, R4 and R5 have the meanings indicated in the specification.Type: GrantFiled: May 25, 2004Date of Patent: April 28, 2009Assignee: Sanofi-Aventis Deutschland GmbHInventors: Martin Michaelis, Gerd Geisslinger, Klaus Scholich