Nitrogen In Substituent Q Patents (Class 564/86)
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Patent number: 4405358Abstract: Aralkylaniline derivatives of the general formula ##STR1## where R is alkoxy, cycloalkoxy, alkenyloxy, alkynyloxy, cyanoalkoxy, haloalkoxy, alkylthio, alkenylthio or alkynylthio or unsubstituted or substituted alkyl, cycloalkyl, alkenyl or alkynyl, Y is hydrogen, alkyl, halogen, alkoxy or haloalkyl, A is unsubstituted or substituted alkylene, Z is hydrogen, alkyl, haloalkyl, alkoxyalkyl, cycloalkyl, aralkyl, aryl, aryloxy, halogen, a C.sub.4 H.sub.4 -chain which is fused to the benzene radical to form an unsubstituted or substituted naphthyl radical, alkoxy, haloalkoxy, alkylthio, thiocyanato, cyano, ##STR2## R' and R" each, independently of one another, being hydrogen, alkyl, alkoxy, alkylthio, cycloalkyl or unsubstituted or substituted phenyl, and n is an integer from 1 to 4, and herbicides containing these compounds.Type: GrantFiled: May 1, 1981Date of Patent: September 20, 1983Assignee: BASF AktiengesellschaftInventors: Ulrich Schirmer, Wolfgang Rohr, Bruno Wuerzer
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Patent number: 4376729Abstract: This invention relates to novel (N-substituted sulfonamido) monoazo and disazo compounds, to acid-addition salts of said azo compounds which are useful as direct dyes particularly in the dyeing of cellulose, to novel (N-substituted sulfonamido) substituted nitrobenzene, aniline and acetanilide intermediates to said azo compounds and to methods of preparation of said azo compounds and said intermediates to said azo compounds.Type: GrantFiled: October 8, 1980Date of Patent: March 15, 1983Assignee: Sterling Drug Inc.Inventor: Nathan N. Crounse
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Patent number: 4374840Abstract: A compound represented by the following formula ##STR1## wherein A represents a direct bond or the bond --0--CH.sub.2--,B represents a C.sub.1 -C.sub.11 alkylene group bonded to a carbon atom of the aromatic ring D either directly or through --O--, --S--, --SO-- or --NH--,W represents a carbon or nitrogen atom,R.sub.1 represents a C.sub.3 -C.sub.7 alkyl group, a hydroxy-C.sub.1 -C.sub.6 alkyl group, or a phenyl- or diphenyl-alkyl group with the alkyl group having 1 to 4 carbon atoms,R.sub.2 represents a member selected from the group consisting of hydrogen, halogen, OH, C.sub.1 -C.sub.4 alkyl, NO.sub.2, C.sub.1 -C.sub.4 alkoxy, acetyl, allyloxy, carbamoyl and sulfamoyl, and when two or more R.sub.2 groups exist, they may be identical or different, andn represents 1, 2 or 3 and m represents 1 or 2, provided that n+m.gtoreq.4;and an acid addition salt thereof; a process for producing the same; and a pharmaceutical composition comprising aforesaid compound.Type: GrantFiled: February 11, 1981Date of Patent: February 22, 1983Assignee: Kowa Company, Ltd.Inventors: Masami Shiratsuchi, Noboru Shimizu, Hiromichi Shigyo, Yoshinori Kyotani, Hisashi Kunieda, Kiyoshi Kawamura, Seiichi Sato, Toshihiro Akashi, Masahiko Nagakura, Naotoshi Sawada, Yasumi Uchida
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Patent number: 4373106Abstract: Novel sulfamoyl-substituted phenethylamine derivatives which exhibit .alpha.-adrenergic blocking action and are useful as an antihypertensive agent and an agent for the treatment of congestive heart failure.Type: GrantFiled: February 4, 1981Date of Patent: February 8, 1983Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Kazuo Imai, Kunihiro Niigata, Takashi Fujikura, Shinichi Hashimoto, Toichi Takenaka
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Patent number: 4361557Abstract: Described are D-(threo)-1-aryl-2-acylamido-3-fluoro-1-propanol esters and salts thereof, methods for their preparation, and methods for their use as antibacterial agents.Type: GrantFiled: August 10, 1981Date of Patent: November 30, 1982Assignee: Schering CorporationInventor: Tattanhalli L. Nagabhushan
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Patent number: 4337274Abstract: Diphenylethers of the formula: ##STR1## their synthesis, formulations containing them, methods of making such formulations, and their use in the treatment of liver fluke infections in mammals.Type: GrantFiled: May 29, 1979Date of Patent: June 29, 1982Assignee: Burroughs Wellcome Co.Inventor: John H. Gorvin
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Patent number: 4332941Abstract: Cyclohexanones and -hexenones ##STR1## R.sup.1 is hydrogen or--CO--O--C.sub.n H.sub.2n+1-m (--NR.sup.4 R.sup.5) (1c)R.sup.2 is a group 1c, R.sup.3 is C.sub.1 - to C.sub.10 -alkyl, phenyl or phenyl substituted by lower alkyl, lower alkoxy, trifluoromethyl, nitro, cyano, chloro, carbamoyl, lower-alkyl-carbamoyl, sulfamoyl or lower-alkyl-sulfamoyl, R.sup.4 and R.sup.5 are lower alkyl or --NR.sup.4 R.sup.5 is pyrrolidinyl, piperidyl or morpholyl, m is 1 or 2 and n is 2 to 6, are obtained by reacting 2 mols of an esterCH.sub.3 --CO--CH.sub.2 --CO--O--C.sub.n H.sub.2n+1-m (--NR.sup.4 R.sup.5).sub.m (2)with an aldehyde R.sup.3 --CHO (3). The compounds (1) easily saponify and decarboxylate without an added catalyst to form a cyclohexenones ##STR2## while setting free the alcoholHO--C.sub.n H.sub.2n+1-m (--NR.sup.4 R.sup.5).sub.m (5)which reacts without a catalyst with diketene to form the ester (2).Type: GrantFiled: October 10, 1980Date of Patent: June 1, 1982Assignee: Hoechst AktiengesellschaftInventors: Rudiger Berthold, Werner H. Muller
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Patent number: 4330542Abstract: The invention relates to novel aniline derivatives of the formula: ##STR1## wherein R.sub.1 and R.sub.2 represent a hydrogen or chlorine atom, an allyloxy, acetamide or carboxamide group, R.sub.3 represents a methyl or an optionally substituted phenyl group, R.sub.4 represents a hydrogen atom and R.sub.5 an isopropyl, terbutyl, 2-phenoxy-ethyl or 3-phenyl-propyl group or R.sub.3 and R.sub.5 taken together form with the nitrogen atom a substituted heterocyclic group.The compounds of the invention are useful for the treatment of angina pectoris.Type: GrantFiled: May 16, 1980Date of Patent: May 18, 1982Assignee: SanofiInventors: Marcel Descamps, Charles Goldenberg
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Patent number: 4330468Abstract: Water-soluble monoazo dyes for nylon having the formula: ##STR1## wherein ring A may optionally be substituted by halogen, trifluoromethyl, alkoxy, acylamino or alkyl having from 1 to 4 carbon atoms, R represents hydrogen or unbranched alkyl having from 1 to 4 carbon atoms, R.sup.1 represents hydrogen, alkyl or hydroxyalkyl, X represents unbranched alkyl having from 1 to 6 carbon atoms, cycloalkyl, halogen, nitro, trifluoromethyl, sulpho, vinylsulphonyl, hydroxyethylsulphonyl, sulphatoethylsulphonyl, --SO.sub.2 NHR.sup.2, wherein R.sup.2 represents hydrogen or alkyl having from 1 to 4 carbon atoms, or --COOR.sup.3 wherein R.sup.3 represents hydrogen, alkyl having from 1 to 7 carbon atoms, cycloalkyl or aryl, and n represents an integer of from 0 to 3.The dyes are suitable for application to polyamide textile materials. They give a high degree of thermal stability and fastness to wet treatments and to light.Type: GrantFiled: July 26, 1978Date of Patent: May 18, 1982Assignee: Imperial Chemical Industries, LimitedInventors: David Brierley, Denis R. A. Ridyard, Michael Yelland
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Patent number: 4327113Abstract: Novel 1-heterocyclyloxy- or 1-aryloxy-3-amidoalkylamino-2-propanol derivatives, processes for their manufacture, pharmaceutical compositions containing them and methods of using them in the treatment of heart diseases. The compounds possess .beta.-adrenergic blocking activity. Representative of the compounds disclosed is 1-(4-indolyloxy)-3-.beta.-isobutyramidoethylamino-2-propanol.Type: GrantFiled: December 12, 1980Date of Patent: April 27, 1982Assignee: Imperial Chemical Industries LimitedInventor: Leslie H. Smith
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Patent number: 4321373Abstract: This invention relates to 2-hydroxy-3-naphthoic acid amides of the general formula: ##STR1## wherein R.sub.1 is hydrogen, a substituted or unsubstituted alkyl, cycloalkyl, aralkyl, or aryl group, and R.sub.2 and R.sub.3 are identical or different and are hydrogen, a substituted or unsubstituted alkyl, cycloalkyl, aralkyl, or aryl group, or, together with the nitrogen atom to which they are attached, a substituted or unsubstituted heterocyclic group. The compounds are useful as coupling components for diazo printing.Type: GrantFiled: August 29, 1980Date of Patent: March 23, 1982Assignee: Hoechst AktiengesellschaftInventor: Siegfried Scheler
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Patent number: 4311857Abstract: Described are D-(threo)-1-aryl-2-acylamido-3-fluoro-1-propanol esters and salts thereof, methods for their preparation, and methods for their use as antibacterial agents.Type: GrantFiled: April 4, 1980Date of Patent: January 19, 1982Assignee: Schering CorporationInventor: Tattanahalli L. Nagabhushan
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Patent number: 4297357Abstract: N-phenethylacetamide compounds of the formula: ##STR1## wherein X.sub.1 represents a lower alkoxy group, X.sub.2 represents a hydrogen atom or a lower alkoxy group and R represents a phenyl group, a pyridyl group, a pyrimidinyl group or a benzoyl group, each of which may have one or more substituents selected from a halogen atom, a carbamoyl group, a lower alkoxy group, a sulfamoyl group, an amino group, a lower alkylamino group, a lower alkylthio group, a hydroxy group and a lower alkoxycarbonyl group; the parmaceutically acceptable acid addition salts and hydrates thereof; as well as the process for preparing such compounds and salts and hydrates thereof; the compounds, their salts and their hydrates having a distinct anti-peptic ulcer activity in human and animals.Type: GrantFiled: August 27, 1979Date of Patent: October 27, 1981Assignee: Daiichi Seiyaku Co., Ltd.Inventors: Tosaku Miki, Masahide Asano
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Patent number: 4289892Abstract: Active hydrogen-containing fluorochemical is used as a foam stabilizer for polyurethane foams. For example, rigid or flexible polyurethane foams with high or low density and uniform cellular structure are prepared using fluoroaliphatic radical-substituted poly(oxyalkylene) polyols as foam stabilizers.Type: GrantFiled: April 30, 1979Date of Patent: September 15, 1981Assignee: Minnesota Mining and Manufacturing CompanyInventor: Fredrich A. Soch
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Patent number: 4283556Abstract: A process for the manufacture of a substantially isomerically pure acylanilide of the structure ##STR1## where R is hydrogen, lower alkyl, hydroxy-lower alkyl or lower alkoxy-lower alkyl;R.sub.1 is lower alkyl, phenyl, lower alkylphenyl, lower alkoxy, lower alkoxyphenyl, chlorophenyl, nitrophenyl, dichlorophenyl, chloro-lower alkyl, cyano-lower alkyl, lower alkyl amino, sulfamoylphenyl, carbamoylphenyl or lower alkoxy-lower alkyl; andX is --CO-- or --SO.sub.2 --;comprising the step of treating an alcohol solution of a diamino compound of the structure ##STR2## with an acylating agent, to give an alcohol solution of the acylanilide, wherein substantially equivalent amounts of the acylating agent and the diamino compound are used and wherein the treatment is carried out by the slow, drop-wise addition of the acylating agent at a temperature in the range of about 0.degree. to 5.degree. C.Type: GrantFiled: February 7, 1980Date of Patent: August 11, 1981Assignee: Toms River Chemical CorporationInventor: Philip C. Lang
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Patent number: 4279911Abstract: The invention relates to compounds of the general formula (I) ##STR1## and physiologically acceptable salts, N-oxides, hydrates and bioprecursors thereof, in which Y represents .dbd.O, .dbd.S, .dbd.CHNO.sub.2 or .dbd.NR.sub.3 where R.sub.3 represents hydrogen, nitro, cyano, lower alkyl, aryl, lower alkylsulphonyl or arylsulphonyl; R.sub.1 and R.sub.2, which may be the same or different, each represent hydrogen lower alkyl, cycloalkyl, lower alkenyl, aralkyl, hydroxy, lower trifluoroalkyl, lower alkyl substituted by hydroxy, lower alkoxy, amine, lower alkylamino or dialkylamino, or R.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached form a 5 to 7 membered heterocyclic ring which may contain other heteroatoms or the group ##STR2## where R.sub.Type: GrantFiled: June 6, 1980Date of Patent: July 21, 1981Assignee: Glaxo Group LimitedInventors: Michael Martin-Smith, Barry J. Price, John Bradshaw, John W. Clitherow
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Patent number: 4267104Abstract: Disclosed are new azo dyes prepared by diazotizing selected substituted anilines and coupling with aniline couplers containing sulfate ester groups. These dyes impart fast yellow to reddish-orange shades on polyamide fibers and also color cellulose acetate and wool. The dyes have the following general formula: ##STR1## wherein R is selected from a variety of groups such as alkyl, alkoxy, aryl, cycloalkyl, aryloxy, NH.sub.2, and NH alkyl; X is hydrogen, halogen, alkyl, or the like; Y is hydrogen or halogen; R.sub.1 is selected from groups such as hydrogen, alkyl, alkoxy, halogen, acylamido, alkylthio, and aryloxy; R.sub.2 is selected from such groups as hydrogen, alkyl, aryl and cycloalkyl; Z is a linking group such as alkylene; M is H.sup.+, Na.sup.+, K.sup.+, or NH.sub.4.sup.+ ; and m is 0, 1, or 2.Type: GrantFiled: June 14, 1979Date of Patent: May 12, 1981Assignee: Eastman Kodak CompanyInventors: Ralph R. Giles, Max A. Weaver
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Patent number: 4266078Abstract: Described herein are herbicidal compositions comprised of a thiocarbamate or haloacetanilide herbicide and an antidotally effective amount of an N-acylsulfonamide compound corresponding to the formula ##STR1## in which R is selected from the group consisting of hydrogen, methyl, chloro, acetamido, and 1-4 carbon alkoxyamido;R.sub.1 is selected from the group consisting of hydrogen, allyl, and metal ion;R.sub.2 is selected from the group consisting of 1-10 carbon alkyl, 1-4 carbon haloalkyl, 2-4 carbon alkenyl, 2-4 carbon haloalkenyl, acetonyl, 1-6 carbon alkoxy, 1-4 carbon alkoxycarbonyl, 1-4 carbon alkylthioalkyl, alkoxyalkyl, O,O-dialkylphosphorodithioylalkyl, phenyl, halophenyl, halophenylthioalkyl, cyclohexanedione, and dimethyl barbituric acid; orR.sub.1 and R.sub.2 together with the carbonyl group to which R.sub.2 is attached are selected from the group consisting of succinimide, substituted succinimide, phthalimide, and substituted phthalimide.Type: GrantFiled: April 20, 1979Date of Patent: May 5, 1981Assignee: Stauffer Chemical CompanyInventor: Ferenc M. Pallos
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Patent number: 4258059Abstract: Compounds of the formula ##STR1## wherein: Ar and Ar' are independently alicyclic aryl or heterocyclic aryl groups;R.sub.1 is a substituent replacing a hydrogen on the ring and is independently hydroxy, alkyl, alkoxy, halogen, nitro, amino, monoalkyl-amino, dialkyl-amino, sulfhydryl, alkylmercapto, sulfonamido, carboxy, carbalkoxy, or trihalomethyl;n is an integer from 0 to 5 inclusive;R.sub.2 and R.sub.3 are independently hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, phenyl, or cycloalkyl-alkyl; andR.sub.4 and R.sub.5 are independently halogen or trihalomethyl, with the proviso that when both Ar and Ar' are phenyl and n is 0, both R.sub.2 and R.sub.3 are not hydrogen.Type: GrantFiled: June 21, 1979Date of Patent: March 24, 1981Assignee: USV Pharmaceutical CorporationInventors: Joseph Auerbach, Martin L. Kantor
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Patent number: 4256767Abstract: A new phenoxy alkylamide is disclosed. The compound has been found to have beneficial activity in the field of immuno-stimulation.Type: GrantFiled: June 19, 1979Date of Patent: March 17, 1981Assignee: Societe d'Etudes de Produits ChimiquesInventor: Andre Esanu
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Patent number: 4247460Abstract: A dyestuff particularly for synthetic fibers of the formula ##STR1## wherein R.sub.1 ' denotes hydrogen, methyl, ethyl or cyclohexyl,R.sub.2 ' denotes chlorine, methoxy, methyl, ethoxy, ethyl, trifluoromethyl or acetylamino,R.sub.3 ' denotes hydrogen, methyl, methoxy, ethyl and ethoxy,R.sub.4 ' denotes hydrogen, methyl, methoxy, ethyl and ethoxy,R.sub.5 ' denotes hydrogen, methyl, methoxy, chlorine or phenyl,R.sub.6 ' denotes hydrogen or methyl,R.sub.7 ' denotes hydrogen, methyl, ethyl, 2-hydroxyethyl, 2-hydroxypropyl and 2-hydroxybutyl,m' denotes 0 or 1 andX denotes optionally branched C.sub.2 to C.sub.4 alkylene.Type: GrantFiled: September 13, 1978Date of Patent: January 27, 1981Assignee: Bayer AktiengesellschaftInventors: Herbert Hugl, Gerhard Wolfrum
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Patent number: 4247479Abstract: Aromatic amines are obtained in high yield and purity by treating the corresponding cyclohex-2-en-1-on-oxime hydrochlorides with the at least threefold molar amount of acetic anhydride.Type: GrantFiled: June 5, 1979Date of Patent: January 27, 1981Assignee: Hoechst AktiengesellschaftInventor: Rudiger Berthold
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Patent number: 4235892Abstract: Described are D-(threo)-1-aryl-2-acylamido-3-fluoro-1-propanols, methods for their preparation, and methods for their use as antibacterial agents.Of particular interest are D-(threo)-1-p-nitrophenyl-2-dichloroacetamido-3-fluoro-1-propanol and D-(threo)-1-p-methylsulfonylphenyl-2-dichloroacetamido-3-fluoro-1-propanol and the corresponding 2-difluoroacetamido compounds which are the 3-fluoro-3-deoxy analogs of chloramphenicol, thiamphenicol, difluoroacetyl analog of chloramphenicol, and of fluorthiamphenicol, respectively, and which are active both against organisms sensitive to and resistant to the parent amphenicol antibiotics.Other particularly valuable antibacterial agents include the corresponding 2-(chlorofluoroacetamido)-, 2-dichlorodeuterioacetamido, 2-difluorodeuterioacetamido-, and the 2-(chlorofluorodeuterioacetamido)- derivatives of the foregoing 3-fluoro-3-deoxy amphenicols.Type: GrantFiled: February 5, 1979Date of Patent: November 25, 1980Assignee: Schering Corporation, Patent Dept.Inventor: Tattanahalli L. Nagabhushan
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Patent number: 4235996Abstract: This disclosure describes 9,10-dihydroanthracene-9,10-dicarboxaldehyde-bis-hydrazones and derivatives thereof useful as antibacterial agents, for inhibiting the growth of transplanted mouse tumors, and for inducing the regression and/or palliation of leukemia and related cancers in mammals.Type: GrantFiled: September 19, 1978Date of Patent: November 25, 1980Assignee: American Cyanamid CompanyInventors: Ralph G. Child, Stanley A. Lang, Jr., Ving J. Lee, Yang-I Lin