Benzene Ring In A Substituent E Patents (Class 564/97)
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Patent number: 4533713Abstract: Compounds containing (a) a fluoroaliphaticsulfonamido moiety, and (b) a moiety containing (1) at least two oxirane groups, (2) at least two non-terminal N-.beta.-hydroxyalkylene groups, or (3) at least one oxirane group and at least one non-terminal N-.beta.-hydroxyalkylene group. The compound is capable of being cured with a curing agent to give a cured product having excellent water resistance and oil resistance.Type: GrantFiled: May 6, 1983Date of Patent: August 6, 1985Assignee: Minnesota Mining and Manufacturing CompanyInventor: Richard D. Howells
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Patent number: 4525586Abstract: The present specification provides novel analogs of carbacyclin (CBA.sub.2), 6a-carba-prostacyclin (6a-carba-PGI.sub.2), which have pronounced prostacyclin-like pharmacological activity, e.g., as platelet anti-aggregatory agents. Specifically the novel chemical analogs of CBA.sub.2 are those substituted by fluoro (C-5), alkyl (C-9), interphenylene (C-5), methano (C-6a,9), and an additional (olefinic) valence bond (C-6a,9). Further provided are benzindene analogs of CBA.sub.2 and substituted forms thereof, i.e., 9-deoxy-2', 9-methano (or 2', 9-methano)-3-oxa-4,5,6-trinor-3,7-(1',3'-interphenylene)-PGF.sub.1 compounds. Also provided are a variety of novel chemical intermediates, e.g., substituted bicyclo[3.3.0]octane intermediates, and chemical process utilizing such intermediates which are useful in the preparation of the novel CBA.sub.2 analogs.Type: GrantFiled: September 19, 1983Date of Patent: June 25, 1985Assignee: The Upjohn CompanyInventor: Paul A. Aristoff
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Patent number: 4511735Abstract: The present invention relates to novel fungicides of the formula: ##STR1## wherein R.sup.1 is lower alkyl, lower akenyl, lower alkynyl or aryl of 6 to 10 carbon atoms optionally substituted with up to 3 halogen atoms; R.sup.2 is lower alkyl, lower alkenyl, lower alkynyl or aryl of 6 to 10 carbon atoms optionally substituted with up to 3 halogen atoms or up to 3 lower alkoxy groups; and R.sup.3 is alkyl of 1 to 3 carbon atoms substituted with 3 to 6 halogen atoms or trihalovinyl.Type: GrantFiled: September 30, 1983Date of Patent: April 16, 1985Assignee: Chevron Research CompanyInventor: Philip S. Magee
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Patent number: 4501921Abstract: A stereo-selective preparation of novel sulfonated o-phenylenediamines carrying a trans-.alpha.-alkylidenebenzyl group at the 5-position, which are intermediates in the synthesis of antiviral benzimidazoles.Type: GrantFiled: November 18, 1982Date of Patent: February 26, 1985Assignee: Eli Lilly and CompanyInventors: Charles W. Ryan, Bruce A. Slomski
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Patent number: 4490555Abstract: Novel compounds of the following general formula: ##STR1##Type: GrantFiled: March 19, 1982Date of Patent: December 25, 1984Assignee: The Upjohn CompanyInventor: John C. Sih
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Patent number: 4487960Abstract: Novel compounds of the following formula: ##STR1##Type: GrantFiled: April 19, 1982Date of Patent: December 11, 1984Assignee: The Upjohn CompanyInventor: Chiu-Hong Lin
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Patent number: 4487961Abstract: Novel compounds of the following general formula: ##STR1##Type: GrantFiled: February 16, 1982Date of Patent: December 11, 1984Assignee: The Upjohn CompanyInventor: Paul A. Aristoff
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Patent number: 4473704Abstract: 1,2,3,4,4a,4b,5,6,7,8,8a,12b-Dodecahydro-7-(oxo, hydroxy or amino)-9-hydroxy-11-(alkyl, alkoxy or alkoxyalkyl)triphenylenes, 2,3,3a,3b,4,5,6,7,7a,11b-decahydro-6-(oxo, hydroxy or amino)-8-hydroxy-10-(alkyl, alkoxy or alkoxyalkyl)-1H-cyclopenta[1]phenanthrenes, 2,3,4,4a,4b,5,6,7,8,8a-decahydro-7-(oxo, hydroxy or amino)-9-hydroxy-11-(alkyl, alkoxy, alkoxyalkyl, aralkyl, aralkoxy, aryloxyalkyl or aralkoxyalkyl)-1H-pyrido[1,2-f]phenanthridines, and 1,2,3,3a,3b,4,5,6,7,7a-decahydro-6-(oxo, hydroxy or amino)-8-hydroxy-10-(alkyl, alkoxy or alkoxyalkyl)pyrrolo[1,2-f]phenanthridines and derivatives are valuable as central nervous system active agents or as intermediates to compounds having such activity.Type: GrantFiled: March 16, 1982Date of Patent: September 25, 1984Assignee: Pfizer Inc.Inventors: James F. Eggler, Michael R. Johnson, Lawrence S. Melvin, Jr.
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Patent number: 4420632Abstract: The present specification provides novel analogs of carbacyclin (CBA.sub.2), 6a-carba-prostacyclin (6a-carba-PGI.sub.2), which have pronounced prostacyclin-like pharmacological activity, e.g., as platelet antiaggregatory agents. Specifically the novel chemical analogs of CBA.sub.2 are those substituted by fluoro (C-5), alkyl (C-9), interphenylene (C-5), and methano (C-6a,9). Further provided are benzindene analogs of CBA.sub.2 and substituted forms thereof, i.e., 9-deoxy-2',9-methano (or 2',9-metheno)-3-oxa-4,5,6-trinor-3,7-(1',3'-interphenylene)-PGF.sub.1 compounds. Also provided are a variety of novel chemical intermediates, e.g., substituted bicyclo[3.3.0]octane intermediates, and chemical process utilizing such intermediates which are useful in the preparation of the novel CBA.sub.2 analogs.Type: GrantFiled: December 22, 1980Date of Patent: December 13, 1983Assignee: The Upjohn CompanyInventor: Paul A. Aristoff
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Patent number: 4417896Abstract: Novel compounds of the general formula ##STR1## wherein Z represents a substituted lower alkyl radical; each of R.sub.1 and R.sub.2 is hydrogen atom, a lower alkyl or a substituted lower alkyl identical with or different from Z and the functional groups NO.sub.2 and NR.sub.1 R.sub.2 can occupy all ring positions in relation to OZ, with the exception that if Z is .beta.-hydroxyethyl, --NO.sub.2 is in the 4 position and --N(R.sub.1)(R.sub.2) is in the 2 position then either R.sub.1 or R.sub.2 is other than hydrogen.The novel compounds are for dyeing human hair in a variety of yellow shades. The compounds of formula (I) may be used as aqueous or water-alcohol solutions to form dye compositions for dyeing human hair.Type: GrantFiled: April 6, 1982Date of Patent: November 29, 1983Assignee: Societe Anonyme dite: L'OrealInventors: Andree Bugaut, Patrick Andrillon
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Patent number: 4405359Abstract: Acyclicacylaminoperfluoroalanesulfonanilides and agriculturally acceptable salts thereof are useful as herbicides and plant growth regulators.Type: GrantFiled: March 1, 1982Date of Patent: September 20, 1983Assignee: Minnesota Mining and Manufacturing CompanyInventor: Ezzat A. Mikhail
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Patent number: 4380464Abstract: Disclosure is made of certain optionally substituted N,N-diacylaminoperfluoroalkanesulfonanilides and agriculturally acceptable salts thereof which are useful as herbicides and plant growth regulators.Type: GrantFiled: February 4, 1982Date of Patent: April 19, 1983Assignee: Minnesota Mining and Manufacturing CompanyInventor: Ezzat A. Mikhail
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Patent number: 4352760Abstract: The present invention provides novel substituted heptadeca-5,9- and 5,10-dienoic acid and similar fatty acid compounds which are derivatives of certain prostaglandins and are potent thromboxane A.sub.2 inhibitors. By virtue of this pharmacological property, they represent useful pharmacological agents for a wide variety of purposes.Type: GrantFiled: December 29, 1980Date of Patent: October 5, 1982Assignee: The Upjohn CompanyInventor: Kirk M. Maxey
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Patent number: 4349689Abstract: The present specification provides novel analogs of carbacyclin (CBA.sub.2), 6a-carba-prostacyclin (6a-carba-PGI.sub.2), which have pronounced prostacyclin-like pharmacological activity, e.g., as platelet anti-aggregatory agents. Specifically the novel chemical analogs of CBA.sub.2 are those substituted by fluoro (C-5), alkyl (C-9), interphenylene (C-5), and methano (C-6a,9). Further provided are benzindene analogs of CBA.sub.2 and substituted forms thereof, i.e., 9-deoxy-2',9-methano (or 2',9-metheno)-3-oxa-4,5,6-trinor-3,7-(1',3'-interphenylene)-PGF.sub.1 compounds. Also provided are a variety of novel chemical intermediates, e.g., substituted bicyclo[3.3.0]octane intermediates, and chemical process utilizing such intermediates which are useful in the preparation of the novel CBA.sub.2 analogs.Type: GrantFiled: December 22, 1980Date of Patent: September 14, 1982Assignee: The Upjohn CompanyInventor: Paul A. Aristoff
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Patent number: 4349378Abstract: Sulphonanilides of formula ##STR1## and salts thereof, wherein R.sup.1 represents alkyl or certain other groups;R represents alkylene or alkenylene;A represents --COR.sup.12 or a carbonyl derivative or addition compound thereof, where R.sup.12 represents hydrogen, alkyl or certain other groups; andR.sup.2 -R.sup.6 represent hydrogen, alkyl, halogen or certain other groups;are pesticides and plant growth regulants, especially herbicides and fungicides.Type: GrantFiled: December 14, 1978Date of Patent: September 14, 1982Assignee: FBC LimitedInventors: Geoffrey R. Cliff, Russell G. Hunt, Albert Percival
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Patent number: 4338457Abstract: The present invention relates to novel compositions of matter and novel processes for preparing these compositions of matter. Moreover, there are provided novel methods by which certain of these novel compositions of matter are employed for pharmacologically useful purposes.Type: GrantFiled: February 28, 1980Date of Patent: July 6, 1982Assignee: The Upjohn CompanyInventor: Paul A. Aristoff
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Patent number: 4337061Abstract: Novel compounds of the general formula ##STR1## wherein Z represents a substituted lower alkyl radical; each of R.sub.1 and R.sub.2 is hydrogen atom, a lower alkyl or a substituted lower alkyl identical with or different from Z and the functional groups NO.sub.2 and NR.sub.1 R.sub.2 can occupy all ring positions in relation to OZ, with the exception that if Z is .beta.-hydroxyethyl, --NO.sub.2 is in the 4 position and --N(R.sub.1)(R.sub.2) is in the 2 position then either R.sub.1 or R.sub.2 is other than hydrogen.The novel compounds are for dyeing human hair in a variety of yellow shades. The compounds of formula (I) may be used as aqueous or water-alcohol solutions to form dye compositions for dyeing human hair.Type: GrantFiled: May 3, 1976Date of Patent: June 29, 1982Assignee: Societe Anonyme dite: L'OREALInventors: Andree Bugaut, Patrick Andrillon
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Patent number: 4321081Abstract: A compound of the formula: ##STR1## wherein R is C.sub.1 -C.sub.4 alkylamino, C.sub.3 -C.sub.4 alkenylamino, C.sub.3 -C.sub.4 alkynylamino, di(C.sub.1 -C.sub.4)alkylamino, di(C.sub.3 -C.sub.4)alkenylamino, di(C.sub.3 -C.sub.4)alkynylamino, C.sub.1 -C.sub.4 alkyl(C.sub.3 -C.sub.4)alkenylamino, C.sub.1 -C.sub.4 alkyl(C.sub.3 -C.sub.4)alkynylamino, C.sub.1 -C.sub.4 alkoxyamino, C.sub.1 -C.sub.4 alkyl(C.sub.1 -C.sub.4)alkoxyamino, C.sub.1 -C.sub.4 alkylphenylamino, morpholino, thiomorpholino, C.sub.1 -C.sub.4 alkylmorpholino, di(C.sub.1 -C.sub.4)alkylmorpholino, pyrrolidino, C.sub.1 -C.sub.4 alkylpyrrolidino, piperidino, C.sub.1 -C.sub.4 alkylpiperidino, hexamethyleneimino or tetrahydropyridino and n is an integer of 0 or 1, or a salt thereof, which is useful as a herbicide.Type: GrantFiled: April 3, 1981Date of Patent: March 23, 1982Assignee: Sumitomo Chemical Company, LimitedInventors: Hiroyuki Konishi, Shunichi Hashimoto, Hiromichi Oshio
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Patent number: 4312663Abstract: Cyclicacylaminoperfluoroalanesulfonanilides and agriculturally acceptable salts thereof are useful as herbicides and plant growth regulators.Type: GrantFiled: September 18, 1980Date of Patent: January 26, 1982Assignee: Minnesota Mining and Manufacturing CompanyInventor: Ezzat A. Mikhail
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Patent number: 4309425Abstract: Sulfonamides, such as N-[N-(2-chloro-5-(trifluoromethyl)phenyl]-N-[2,4-dinitro-6-(trifluoromethy l)phenyl]aminothio]-N,4-dimethylbenzenesulfonamide, are useful for control of arthropod pests of plants and animals and fungus disease of plants.Type: GrantFiled: April 11, 1980Date of Patent: January 5, 1982Assignee: E. I. Du Pont de Nemours and CompanyInventor: Jiin-Duey Cheng
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Patent number: 4309559Abstract: Sulphonanilides of formula ##STR1## and salts thereof, wherein R.sup.1 represents alkyl or certain other groups;R represents alkylene or alkenylene;A represents --COOH, --COO alkyl, --CSSH, CN or certain related groups; orR-A represents a group of formula ##STR2## where R.sup.14 represents hydrogen, alkyl or aryl, B represents oxygen or ##STR3## R.sup.15 represents hydrogen or alkyl, and n represents 0, 1 or 2; and R.sup.2 -R.sup.6 represent hydrogen; alkyl, halogen or certain other groups,are pesticides and plant growth regulants, especially herbicides and fungicides.Type: GrantFiled: December 14, 1978Date of Patent: January 5, 1982Assignee: FBC LimitedInventor: Geoffrey R. Cliff
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Patent number: 4295874Abstract: N-trichlorovinylthio-substituted halomethanesulfonamides of the formula ##STR1## wherein R is alkyl, cycloalkyl, aryl, X is fluoro, chloro, bromo or iodo and R' is trichlorovinyl, are fungicides and algicides.Type: GrantFiled: January 28, 1980Date of Patent: October 20, 1981Assignee: Chevron ResearchInventor: Laroy H. Edwards
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Patent number: 4296034Abstract: This invention pertains to polyfluorinated sulfonamides having the formulaC.sub.n F.sub.2n+1 --CH.sub.2 --.sub.b SO.sub.2 --NRR'wherein n is a number of from 1 to about 20; b is an integer of from 2 to about 20; R is selected from the group consisting of a hydrogen radical and an alkyl radical having from 1 to about 10 carbon atoms; and R' is selected from the group consisting of a hydrogen radical, an alkyl radical of from 1 to about 10 carbon atoms, a cyclic alkyl radical of from 5 to 12 carbon atoms, and an aryl radical of from about 6 to 12 carbon atoms. These compounds are prepared through the action of polyfluorinated sulfonic chloride on an amino derivative.Type: GrantFiled: May 24, 1979Date of Patent: October 20, 1981Assignee: Produits Chimiques Ugine KuhlmannInventors: Pierre Bouvet, Jean-Pierre Lalu
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Patent number: 4292445Abstract: The present invention relates to novel amido and sulfonamido derivatives of 2-decarboxy-2-amino-methyl-PG-type compounds. These analogs are useful as nasal decongestants, antifertility agents, and as cytoprotection agents.Type: GrantFiled: April 28, 1980Date of Patent: September 29, 1981Assignee: The Upjohn CompanyInventor: Norman A. Nelson
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Patent number: 4292444Abstract: The synthetic prostaglandin derivatives have a C-1 alkylsulfonylcarboxamide group, a trans C-2, C-3 double bond or cis C-4, C-5 double bond and a C-16 aryloxy group and are antiulcer or antifertility agents.Type: GrantFiled: February 8, 1980Date of Patent: September 29, 1981Assignee: Pfizer Inc.Inventors: James F. Eggler, Thomas K. Schaaf
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Patent number: 4288592Abstract: There is provided a process for preparing amides which comprises reacting an amine, or an amide, and an acid halide, or anhydride, in suitable molecular proportions, in an inert organic diluent, in the presence of an effective amount of a molecular sieve, until the reaction is completed, separating the molecular sieve, and recovering the amide from the organic mother liquor.Type: GrantFiled: April 30, 1979Date of Patent: September 8, 1981Assignee: American Cyanamid CompanyInventors: Michael M. Rauhut, Shin-Shyong Tseng
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Patent number: 4285723Abstract: Herbicidal diphenyl ether compounds of the formula ##STR1## wherein R.sup.1 is an alkyl group optionally substituted by halogen or phenyl; R.sup.2 is hydrogen, halogen or nitro; R.sup.3 is hydrogen, halogen, alkyl, trifluoromethyl or cyano; R.sup.4 is hydrogen, halogen, or trifluoromethyl; R.sup.5 is halogen or trifluoromethyl; and R.sup.6 is hydrogen, or C.sub.1 -C.sub.4 alkyl. These compounds are useful as selective herbicides in a range of crops, for example, cotton, soya bean, peas, maize, wheat and rice.Type: GrantFiled: July 12, 1979Date of Patent: August 25, 1981Assignee: Imperial Chemical Industries LimitedInventors: David Cartwright, David J. Collins
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Patent number: 4265831Abstract: A process for the preparation of a hydroxyalkylperfluoroalkane sulphonamide of the formula ##STR1## wherein R.sub.F is a perfluoroalkyl group having from 1 to 20 carbon atoms;R and R' each independently is hydrogen or an alkyl, hydroxyalkyl, haloalkyl, cycloalkyl, aralkyl, alkenyl or aryl radical; andm and n each independently is an integer from 1 to about 30,comprising reacting a perfluoroalkylsulphonamide of the formula ##STR2## with an epoxide of the formula ##STR3## in the presence of a basic catalyst.Type: GrantFiled: July 2, 1979Date of Patent: May 5, 1981Assignee: Bayer AktiengesellschaftInventors: Karl-Heinz Mitschke, Klaus Geisler, Hans Niederprum
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Patent number: 4246419Abstract: A herbicidal sulphonamide compound of the formula (I): ##STR1## and salts thereof, wherein R.sup.1 is a pyridyl group of the formula: ##STR2## wherein the group X of the pyridyl group represents a fluorine, chlorine, bromine, or iodine atom, or an alkyl radical of 1 to 4 carbon atoms optionally substituted by one or more fluorine or chlorine atoms, and the group Y represents hydrogen, fluorine chlorine, bromine, or iodine or an alkyl radical of 1 to 4 carbon atoms optionally substituted by one or more fluorine or chlorine atoms; R.sup.2 represents an alkyl radical of 1 to 6 carbon atoms optionally substituted by one or more fluorine atoms; and R.sup.3 is hydrogen or an alkyl radical of 1 to 4 carbon atoms.Type: GrantFiled: February 5, 1979Date of Patent: January 20, 1981Assignee: Imperial Chemical Industries LimitedInventors: David Cartwright, Roger Salmon
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Patent number: 4246283Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is methyl or ethyl, R.sub.2 is C.sub.1 -C.sub.12 -alkyl, C.sub.3 -C.sub.6 -cycloalkyl or cyclopropylmethyl, R.sub.3 is C.sub.1 -C.sub.4 -alkyl or phenyl optionally mono-, or di- or trisubstituted by halogen and/or methyl and either (i) X.sub.1 is methyl, chlorine, bromine or hydrogen and X.sub.2 is methyl or (ii) X.sub.1 is methyl, chlorine or bromine and X.sub.2 is hydrogen exhibit valuable pesticidal, in particular acaricidal and insecticidal, properties.Type: GrantFiled: June 1, 1977Date of Patent: January 20, 1981Assignee: Ciba-Geigy CorporationInventors: Manfred Boger, Jozef Drabek
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Patent number: 4244960Abstract: Indanyl derivatives of the formula ##STR1## wherein AR is phenyl, pyridyl, or phenyl or pyridyl substituted by halogen, alkyl of 1-4 carbon atoms or trifluoromethyl; X is oxygen or a sulfur; R.sub.1 is alkyl of 1-4 carbon atoms or alkyl of 1-4 carbon atoms substituted by fluorine or chlorine; A is ##STR2## Y is oxo, oximino, C.sub.1-4 -alkoximino of 1-4 carbon atoms, phenylhydrazono or p-toluenesulfonylhydrazono; n is 0, 1 or 2; R.sub.2 is alkyl of 1-4 carbon atoms, phenyl or phenyl substituted by halogen, alkyl of 1-4 carbon atoms, nitro or carboxy; Z is hydroxy, acyloxy of 1 to 6 carbon atoms, R.sub.1 SO.sub.3 -- amino, acylamino of 1 to 6 carbon atoms, R.sub.1 SO.sub.2 NH-- or cyano, and V is hydrogen, acyl of 1 to 6 carbon atoms or R.sub.1 SO.sub.2 --, and the salts thereof with physiologically acceptable bases or acids have valuable pharmacological and herbicidal activity.Type: GrantFiled: July 27, 1979Date of Patent: January 13, 1981Assignee: Schering, AktiengesellschaftInventors: Eberhard Schroder, Clemens Rufer, Irmgard Bottcher, Joachim-Friedrich Kapp