Benzene Ring In A Substituent E Patents (Class 564/97)
  • Patent number: 4533713
    Abstract: Compounds containing (a) a fluoroaliphaticsulfonamido moiety, and (b) a moiety containing (1) at least two oxirane groups, (2) at least two non-terminal N-.beta.-hydroxyalkylene groups, or (3) at least one oxirane group and at least one non-terminal N-.beta.-hydroxyalkylene group. The compound is capable of being cured with a curing agent to give a cured product having excellent water resistance and oil resistance.
    Type: Grant
    Filed: May 6, 1983
    Date of Patent: August 6, 1985
    Assignee: Minnesota Mining and Manufacturing Company
    Inventor: Richard D. Howells
  • Patent number: 4525586
    Abstract: The present specification provides novel analogs of carbacyclin (CBA.sub.2), 6a-carba-prostacyclin (6a-carba-PGI.sub.2), which have pronounced prostacyclin-like pharmacological activity, e.g., as platelet anti-aggregatory agents. Specifically the novel chemical analogs of CBA.sub.2 are those substituted by fluoro (C-5), alkyl (C-9), interphenylene (C-5), methano (C-6a,9), and an additional (olefinic) valence bond (C-6a,9). Further provided are benzindene analogs of CBA.sub.2 and substituted forms thereof, i.e., 9-deoxy-2', 9-methano (or 2', 9-methano)-3-oxa-4,5,6-trinor-3,7-(1',3'-interphenylene)-PGF.sub.1 compounds. Also provided are a variety of novel chemical intermediates, e.g., substituted bicyclo[3.3.0]octane intermediates, and chemical process utilizing such intermediates which are useful in the preparation of the novel CBA.sub.2 analogs.
    Type: Grant
    Filed: September 19, 1983
    Date of Patent: June 25, 1985
    Assignee: The Upjohn Company
    Inventor: Paul A. Aristoff
  • Patent number: 4511735
    Abstract: The present invention relates to novel fungicides of the formula: ##STR1## wherein R.sup.1 is lower alkyl, lower akenyl, lower alkynyl or aryl of 6 to 10 carbon atoms optionally substituted with up to 3 halogen atoms; R.sup.2 is lower alkyl, lower alkenyl, lower alkynyl or aryl of 6 to 10 carbon atoms optionally substituted with up to 3 halogen atoms or up to 3 lower alkoxy groups; and R.sup.3 is alkyl of 1 to 3 carbon atoms substituted with 3 to 6 halogen atoms or trihalovinyl.
    Type: Grant
    Filed: September 30, 1983
    Date of Patent: April 16, 1985
    Assignee: Chevron Research Company
    Inventor: Philip S. Magee
  • Patent number: 4501921
    Abstract: A stereo-selective preparation of novel sulfonated o-phenylenediamines carrying a trans-.alpha.-alkylidenebenzyl group at the 5-position, which are intermediates in the synthesis of antiviral benzimidazoles.
    Type: Grant
    Filed: November 18, 1982
    Date of Patent: February 26, 1985
    Assignee: Eli Lilly and Company
    Inventors: Charles W. Ryan, Bruce A. Slomski
  • Patent number: 4490555
    Abstract: Novel compounds of the following general formula: ##STR1##
    Type: Grant
    Filed: March 19, 1982
    Date of Patent: December 25, 1984
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • Patent number: 4487960
    Abstract: Novel compounds of the following formula: ##STR1##
    Type: Grant
    Filed: April 19, 1982
    Date of Patent: December 11, 1984
    Assignee: The Upjohn Company
    Inventor: Chiu-Hong Lin
  • Patent number: 4487961
    Abstract: Novel compounds of the following general formula: ##STR1##
    Type: Grant
    Filed: February 16, 1982
    Date of Patent: December 11, 1984
    Assignee: The Upjohn Company
    Inventor: Paul A. Aristoff
  • Patent number: 4473704
    Abstract: 1,2,3,4,4a,4b,5,6,7,8,8a,12b-Dodecahydro-7-(oxo, hydroxy or amino)-9-hydroxy-11-(alkyl, alkoxy or alkoxyalkyl)triphenylenes, 2,3,3a,3b,4,5,6,7,7a,11b-decahydro-6-(oxo, hydroxy or amino)-8-hydroxy-10-(alkyl, alkoxy or alkoxyalkyl)-1H-cyclopenta[1]phenanthrenes, 2,3,4,4a,4b,5,6,7,8,8a-decahydro-7-(oxo, hydroxy or amino)-9-hydroxy-11-(alkyl, alkoxy, alkoxyalkyl, aralkyl, aralkoxy, aryloxyalkyl or aralkoxyalkyl)-1H-pyrido[1,2-f]phenanthridines, and 1,2,3,3a,3b,4,5,6,7,7a-decahydro-6-(oxo, hydroxy or amino)-8-hydroxy-10-(alkyl, alkoxy or alkoxyalkyl)pyrrolo[1,2-f]phenanthridines and derivatives are valuable as central nervous system active agents or as intermediates to compounds having such activity.
    Type: Grant
    Filed: March 16, 1982
    Date of Patent: September 25, 1984
    Assignee: Pfizer Inc.
    Inventors: James F. Eggler, Michael R. Johnson, Lawrence S. Melvin, Jr.
  • Patent number: 4420632
    Abstract: The present specification provides novel analogs of carbacyclin (CBA.sub.2), 6a-carba-prostacyclin (6a-carba-PGI.sub.2), which have pronounced prostacyclin-like pharmacological activity, e.g., as platelet antiaggregatory agents. Specifically the novel chemical analogs of CBA.sub.2 are those substituted by fluoro (C-5), alkyl (C-9), interphenylene (C-5), and methano (C-6a,9). Further provided are benzindene analogs of CBA.sub.2 and substituted forms thereof, i.e., 9-deoxy-2',9-methano (or 2',9-metheno)-3-oxa-4,5,6-trinor-3,7-(1',3'-interphenylene)-PGF.sub.1 compounds. Also provided are a variety of novel chemical intermediates, e.g., substituted bicyclo[3.3.0]octane intermediates, and chemical process utilizing such intermediates which are useful in the preparation of the novel CBA.sub.2 analogs.
    Type: Grant
    Filed: December 22, 1980
    Date of Patent: December 13, 1983
    Assignee: The Upjohn Company
    Inventor: Paul A. Aristoff
  • Patent number: 4417896
    Abstract: Novel compounds of the general formula ##STR1## wherein Z represents a substituted lower alkyl radical; each of R.sub.1 and R.sub.2 is hydrogen atom, a lower alkyl or a substituted lower alkyl identical with or different from Z and the functional groups NO.sub.2 and NR.sub.1 R.sub.2 can occupy all ring positions in relation to OZ, with the exception that if Z is .beta.-hydroxyethyl, --NO.sub.2 is in the 4 position and --N(R.sub.1)(R.sub.2) is in the 2 position then either R.sub.1 or R.sub.2 is other than hydrogen.The novel compounds are for dyeing human hair in a variety of yellow shades. The compounds of formula (I) may be used as aqueous or water-alcohol solutions to form dye compositions for dyeing human hair.
    Type: Grant
    Filed: April 6, 1982
    Date of Patent: November 29, 1983
    Assignee: Societe Anonyme dite: L'Oreal
    Inventors: Andree Bugaut, Patrick Andrillon
  • Patent number: 4405359
    Abstract: Acyclicacylaminoperfluoroalanesulfonanilides and agriculturally acceptable salts thereof are useful as herbicides and plant growth regulators.
    Type: Grant
    Filed: March 1, 1982
    Date of Patent: September 20, 1983
    Assignee: Minnesota Mining and Manufacturing Company
    Inventor: Ezzat A. Mikhail
  • Patent number: 4380464
    Abstract: Disclosure is made of certain optionally substituted N,N-diacylaminoperfluoroalkanesulfonanilides and agriculturally acceptable salts thereof which are useful as herbicides and plant growth regulators.
    Type: Grant
    Filed: February 4, 1982
    Date of Patent: April 19, 1983
    Assignee: Minnesota Mining and Manufacturing Company
    Inventor: Ezzat A. Mikhail
  • Patent number: 4352760
    Abstract: The present invention provides novel substituted heptadeca-5,9- and 5,10-dienoic acid and similar fatty acid compounds which are derivatives of certain prostaglandins and are potent thromboxane A.sub.2 inhibitors. By virtue of this pharmacological property, they represent useful pharmacological agents for a wide variety of purposes.
    Type: Grant
    Filed: December 29, 1980
    Date of Patent: October 5, 1982
    Assignee: The Upjohn Company
    Inventor: Kirk M. Maxey
  • Patent number: 4349689
    Abstract: The present specification provides novel analogs of carbacyclin (CBA.sub.2), 6a-carba-prostacyclin (6a-carba-PGI.sub.2), which have pronounced prostacyclin-like pharmacological activity, e.g., as platelet anti-aggregatory agents. Specifically the novel chemical analogs of CBA.sub.2 are those substituted by fluoro (C-5), alkyl (C-9), interphenylene (C-5), and methano (C-6a,9). Further provided are benzindene analogs of CBA.sub.2 and substituted forms thereof, i.e., 9-deoxy-2',9-methano (or 2',9-metheno)-3-oxa-4,5,6-trinor-3,7-(1',3'-interphenylene)-PGF.sub.1 compounds. Also provided are a variety of novel chemical intermediates, e.g., substituted bicyclo[3.3.0]octane intermediates, and chemical process utilizing such intermediates which are useful in the preparation of the novel CBA.sub.2 analogs.
    Type: Grant
    Filed: December 22, 1980
    Date of Patent: September 14, 1982
    Assignee: The Upjohn Company
    Inventor: Paul A. Aristoff
  • Patent number: 4349378
    Abstract: Sulphonanilides of formula ##STR1## and salts thereof, wherein R.sup.1 represents alkyl or certain other groups;R represents alkylene or alkenylene;A represents --COR.sup.12 or a carbonyl derivative or addition compound thereof, where R.sup.12 represents hydrogen, alkyl or certain other groups; andR.sup.2 -R.sup.6 represent hydrogen, alkyl, halogen or certain other groups;are pesticides and plant growth regulants, especially herbicides and fungicides.
    Type: Grant
    Filed: December 14, 1978
    Date of Patent: September 14, 1982
    Assignee: FBC Limited
    Inventors: Geoffrey R. Cliff, Russell G. Hunt, Albert Percival
  • Patent number: 4338457
    Abstract: The present invention relates to novel compositions of matter and novel processes for preparing these compositions of matter. Moreover, there are provided novel methods by which certain of these novel compositions of matter are employed for pharmacologically useful purposes.
    Type: Grant
    Filed: February 28, 1980
    Date of Patent: July 6, 1982
    Assignee: The Upjohn Company
    Inventor: Paul A. Aristoff
  • Patent number: 4337061
    Abstract: Novel compounds of the general formula ##STR1## wherein Z represents a substituted lower alkyl radical; each of R.sub.1 and R.sub.2 is hydrogen atom, a lower alkyl or a substituted lower alkyl identical with or different from Z and the functional groups NO.sub.2 and NR.sub.1 R.sub.2 can occupy all ring positions in relation to OZ, with the exception that if Z is .beta.-hydroxyethyl, --NO.sub.2 is in the 4 position and --N(R.sub.1)(R.sub.2) is in the 2 position then either R.sub.1 or R.sub.2 is other than hydrogen.The novel compounds are for dyeing human hair in a variety of yellow shades. The compounds of formula (I) may be used as aqueous or water-alcohol solutions to form dye compositions for dyeing human hair.
    Type: Grant
    Filed: May 3, 1976
    Date of Patent: June 29, 1982
    Assignee: Societe Anonyme dite: L'OREAL
    Inventors: Andree Bugaut, Patrick Andrillon
  • Patent number: 4321081
    Abstract: A compound of the formula: ##STR1## wherein R is C.sub.1 -C.sub.4 alkylamino, C.sub.3 -C.sub.4 alkenylamino, C.sub.3 -C.sub.4 alkynylamino, di(C.sub.1 -C.sub.4)alkylamino, di(C.sub.3 -C.sub.4)alkenylamino, di(C.sub.3 -C.sub.4)alkynylamino, C.sub.1 -C.sub.4 alkyl(C.sub.3 -C.sub.4)alkenylamino, C.sub.1 -C.sub.4 alkyl(C.sub.3 -C.sub.4)alkynylamino, C.sub.1 -C.sub.4 alkoxyamino, C.sub.1 -C.sub.4 alkyl(C.sub.1 -C.sub.4)alkoxyamino, C.sub.1 -C.sub.4 alkylphenylamino, morpholino, thiomorpholino, C.sub.1 -C.sub.4 alkylmorpholino, di(C.sub.1 -C.sub.4)alkylmorpholino, pyrrolidino, C.sub.1 -C.sub.4 alkylpyrrolidino, piperidino, C.sub.1 -C.sub.4 alkylpiperidino, hexamethyleneimino or tetrahydropyridino and n is an integer of 0 or 1, or a salt thereof, which is useful as a herbicide.
    Type: Grant
    Filed: April 3, 1981
    Date of Patent: March 23, 1982
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Hiroyuki Konishi, Shunichi Hashimoto, Hiromichi Oshio
  • Patent number: 4312663
    Abstract: Cyclicacylaminoperfluoroalanesulfonanilides and agriculturally acceptable salts thereof are useful as herbicides and plant growth regulators.
    Type: Grant
    Filed: September 18, 1980
    Date of Patent: January 26, 1982
    Assignee: Minnesota Mining and Manufacturing Company
    Inventor: Ezzat A. Mikhail
  • Patent number: 4309425
    Abstract: Sulfonamides, such as N-[N-(2-chloro-5-(trifluoromethyl)phenyl]-N-[2,4-dinitro-6-(trifluoromethy l)phenyl]aminothio]-N,4-dimethylbenzenesulfonamide, are useful for control of arthropod pests of plants and animals and fungus disease of plants.
    Type: Grant
    Filed: April 11, 1980
    Date of Patent: January 5, 1982
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Jiin-Duey Cheng
  • Patent number: 4309559
    Abstract: Sulphonanilides of formula ##STR1## and salts thereof, wherein R.sup.1 represents alkyl or certain other groups;R represents alkylene or alkenylene;A represents --COOH, --COO alkyl, --CSSH, CN or certain related groups; orR-A represents a group of formula ##STR2## where R.sup.14 represents hydrogen, alkyl or aryl, B represents oxygen or ##STR3## R.sup.15 represents hydrogen or alkyl, and n represents 0, 1 or 2; and R.sup.2 -R.sup.6 represent hydrogen; alkyl, halogen or certain other groups,are pesticides and plant growth regulants, especially herbicides and fungicides.
    Type: Grant
    Filed: December 14, 1978
    Date of Patent: January 5, 1982
    Assignee: FBC Limited
    Inventor: Geoffrey R. Cliff
  • Patent number: 4295874
    Abstract: N-trichlorovinylthio-substituted halomethanesulfonamides of the formula ##STR1## wherein R is alkyl, cycloalkyl, aryl, X is fluoro, chloro, bromo or iodo and R' is trichlorovinyl, are fungicides and algicides.
    Type: Grant
    Filed: January 28, 1980
    Date of Patent: October 20, 1981
    Assignee: Chevron Research
    Inventor: Laroy H. Edwards
  • Patent number: 4296034
    Abstract: This invention pertains to polyfluorinated sulfonamides having the formulaC.sub.n F.sub.2n+1 --CH.sub.2 --.sub.b SO.sub.2 --NRR'wherein n is a number of from 1 to about 20; b is an integer of from 2 to about 20; R is selected from the group consisting of a hydrogen radical and an alkyl radical having from 1 to about 10 carbon atoms; and R' is selected from the group consisting of a hydrogen radical, an alkyl radical of from 1 to about 10 carbon atoms, a cyclic alkyl radical of from 5 to 12 carbon atoms, and an aryl radical of from about 6 to 12 carbon atoms. These compounds are prepared through the action of polyfluorinated sulfonic chloride on an amino derivative.
    Type: Grant
    Filed: May 24, 1979
    Date of Patent: October 20, 1981
    Assignee: Produits Chimiques Ugine Kuhlmann
    Inventors: Pierre Bouvet, Jean-Pierre Lalu
  • Patent number: 4292445
    Abstract: The present invention relates to novel amido and sulfonamido derivatives of 2-decarboxy-2-amino-methyl-PG-type compounds. These analogs are useful as nasal decongestants, antifertility agents, and as cytoprotection agents.
    Type: Grant
    Filed: April 28, 1980
    Date of Patent: September 29, 1981
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson
  • Patent number: 4292444
    Abstract: The synthetic prostaglandin derivatives have a C-1 alkylsulfonylcarboxamide group, a trans C-2, C-3 double bond or cis C-4, C-5 double bond and a C-16 aryloxy group and are antiulcer or antifertility agents.
    Type: Grant
    Filed: February 8, 1980
    Date of Patent: September 29, 1981
    Assignee: Pfizer Inc.
    Inventors: James F. Eggler, Thomas K. Schaaf
  • Patent number: 4288592
    Abstract: There is provided a process for preparing amides which comprises reacting an amine, or an amide, and an acid halide, or anhydride, in suitable molecular proportions, in an inert organic diluent, in the presence of an effective amount of a molecular sieve, until the reaction is completed, separating the molecular sieve, and recovering the amide from the organic mother liquor.
    Type: Grant
    Filed: April 30, 1979
    Date of Patent: September 8, 1981
    Assignee: American Cyanamid Company
    Inventors: Michael M. Rauhut, Shin-Shyong Tseng
  • Patent number: 4285723
    Abstract: Herbicidal diphenyl ether compounds of the formula ##STR1## wherein R.sup.1 is an alkyl group optionally substituted by halogen or phenyl; R.sup.2 is hydrogen, halogen or nitro; R.sup.3 is hydrogen, halogen, alkyl, trifluoromethyl or cyano; R.sup.4 is hydrogen, halogen, or trifluoromethyl; R.sup.5 is halogen or trifluoromethyl; and R.sup.6 is hydrogen, or C.sub.1 -C.sub.4 alkyl. These compounds are useful as selective herbicides in a range of crops, for example, cotton, soya bean, peas, maize, wheat and rice.
    Type: Grant
    Filed: July 12, 1979
    Date of Patent: August 25, 1981
    Assignee: Imperial Chemical Industries Limited
    Inventors: David Cartwright, David J. Collins
  • Patent number: 4265831
    Abstract: A process for the preparation of a hydroxyalkylperfluoroalkane sulphonamide of the formula ##STR1## wherein R.sub.F is a perfluoroalkyl group having from 1 to 20 carbon atoms;R and R' each independently is hydrogen or an alkyl, hydroxyalkyl, haloalkyl, cycloalkyl, aralkyl, alkenyl or aryl radical; andm and n each independently is an integer from 1 to about 30,comprising reacting a perfluoroalkylsulphonamide of the formula ##STR2## with an epoxide of the formula ##STR3## in the presence of a basic catalyst.
    Type: Grant
    Filed: July 2, 1979
    Date of Patent: May 5, 1981
    Assignee: Bayer Aktiengesellschaft
    Inventors: Karl-Heinz Mitschke, Klaus Geisler, Hans Niederprum
  • Patent number: 4246419
    Abstract: A herbicidal sulphonamide compound of the formula (I): ##STR1## and salts thereof, wherein R.sup.1 is a pyridyl group of the formula: ##STR2## wherein the group X of the pyridyl group represents a fluorine, chlorine, bromine, or iodine atom, or an alkyl radical of 1 to 4 carbon atoms optionally substituted by one or more fluorine or chlorine atoms, and the group Y represents hydrogen, fluorine chlorine, bromine, or iodine or an alkyl radical of 1 to 4 carbon atoms optionally substituted by one or more fluorine or chlorine atoms; R.sup.2 represents an alkyl radical of 1 to 6 carbon atoms optionally substituted by one or more fluorine atoms; and R.sup.3 is hydrogen or an alkyl radical of 1 to 4 carbon atoms.
    Type: Grant
    Filed: February 5, 1979
    Date of Patent: January 20, 1981
    Assignee: Imperial Chemical Industries Limited
    Inventors: David Cartwright, Roger Salmon
  • Patent number: 4246283
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is methyl or ethyl, R.sub.2 is C.sub.1 -C.sub.12 -alkyl, C.sub.3 -C.sub.6 -cycloalkyl or cyclopropylmethyl, R.sub.3 is C.sub.1 -C.sub.4 -alkyl or phenyl optionally mono-, or di- or trisubstituted by halogen and/or methyl and either (i) X.sub.1 is methyl, chlorine, bromine or hydrogen and X.sub.2 is methyl or (ii) X.sub.1 is methyl, chlorine or bromine and X.sub.2 is hydrogen exhibit valuable pesticidal, in particular acaricidal and insecticidal, properties.
    Type: Grant
    Filed: June 1, 1977
    Date of Patent: January 20, 1981
    Assignee: Ciba-Geigy Corporation
    Inventors: Manfred Boger, Jozef Drabek
  • Patent number: 4244960
    Abstract: Indanyl derivatives of the formula ##STR1## wherein AR is phenyl, pyridyl, or phenyl or pyridyl substituted by halogen, alkyl of 1-4 carbon atoms or trifluoromethyl; X is oxygen or a sulfur; R.sub.1 is alkyl of 1-4 carbon atoms or alkyl of 1-4 carbon atoms substituted by fluorine or chlorine; A is ##STR2## Y is oxo, oximino, C.sub.1-4 -alkoximino of 1-4 carbon atoms, phenylhydrazono or p-toluenesulfonylhydrazono; n is 0, 1 or 2; R.sub.2 is alkyl of 1-4 carbon atoms, phenyl or phenyl substituted by halogen, alkyl of 1-4 carbon atoms, nitro or carboxy; Z is hydroxy, acyloxy of 1 to 6 carbon atoms, R.sub.1 SO.sub.3 -- amino, acylamino of 1 to 6 carbon atoms, R.sub.1 SO.sub.2 NH-- or cyano, and V is hydrogen, acyl of 1 to 6 carbon atoms or R.sub.1 SO.sub.2 --, and the salts thereof with physiologically acceptable bases or acids have valuable pharmacological and herbicidal activity.
    Type: Grant
    Filed: July 27, 1979
    Date of Patent: January 13, 1981
    Assignee: Schering, Aktiengesellschaft
    Inventors: Eberhard Schroder, Clemens Rufer, Irmgard Bottcher, Joachim-Friedrich Kapp