Oxy Containing Reactant Patents (Class 568/361)
  • Patent number: 10435344
    Abstract: An inexpensive, stereoselective synthesis for nootkatone, tetrahydronootkatone, and their derivatives is disclosed utilizing ozonolysis. The starting materials used in the synthesis are inexpensive and the reactions are commercially feasible and amenable to scaling up. The principal starting material, (?)-?-Pinene, is on the GRAS list (generally recognized as safe).
    Type: Grant
    Filed: December 8, 2016
    Date of Patent: October 8, 2019
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventor: Roger Laine
  • Patent number: 10017466
    Abstract: The present invention relates to a process for purifying the xanthophylls astaxanthin and canthaxanthin. The process comprises suspending the xanthophyll in an organic solvent or solvent mixture, treating the suspension of the xanthophyll in the organic solvent or solvent mixture at elevated temperature, and subsequent separation off of the xanthophyll from the solvent by a solid-liquid separation, wherein the organic solvent is selected from ketones of the general formula (I) and mixtures of ketones of the general formula (I) where R1 is C1-C4 alkyl and R2 is selected from C1-C6 alkyl, C3-C8 cycloalkyl, phenyl and benzyl, wherein the phenyl rings in the two last-mentioned radicals are unsubstituted or can have 1 or 2 methyl groups, or R1 and R2 together are linear C4-C6 alkylene, which can bear 1, 2 or 3 methyl groups as substituents.
    Type: Grant
    Filed: October 1, 2015
    Date of Patent: July 10, 2018
    Assignee: BASF SE
    Inventors: Bernd Schäfer, Wolfgang Siegel
  • Patent number: 9783475
    Abstract: A method for forming cyclohexanone from cyclohexanol is provided in which two or more cyclohexanol dehydrogenation reactors and associated condensers are operably connected in series so as to increase relative concentration of cyclohexanone in the formed product through the use of Le Châtelier's principle.
    Type: Grant
    Filed: August 3, 2016
    Date of Patent: October 10, 2017
    Assignee: BASF SE
    Inventors: Dennis Eisele, Bita Fillipi
  • Patent number: 9475745
    Abstract: In a process for producing phenol and cyclohexanone, a cleavage feed containing greater than 40 wt % and no greater than 95 wt % cyclohexyl-1-phenyl-1-hydroperoxide, and at least 5 wt % and less than 60 wt % cyclohexylbenzene is mixed with at least phenol, cyclohexanone, water, and sulfuric acid to produce a cleavage reaction mixture containing from 15 wt % to 50 wt % phenol, from 15 wt % to 50 wt % cyclohexanone, from 1 wt % to 10 wt % cyclohexyl-1-phenyl-1-hydroperoxide, from 5 wt % to 60 wt % cyclohexylbenzene, from 0.1 wt % to 4 wt % water, and from 10 wppm to 1000 wppm sulfuric acid. The cleavage reaction mixture is then reacted at a temperature from 30° C. and to 70° C., and a pressure of at least 1 atmosphere for a time sufficient to convert at least 50% of said cyclohexyl-1-phenyl-1-hydroperoxide in said cleavage reaction mixture and produce a cleavage effluent containing phenol and cyclohexanone.
    Type: Grant
    Filed: November 13, 2013
    Date of Patent: October 25, 2016
    Assignee: ExxonMobil Chemical Patents Inc.
    Inventors: Keith H. Kuechler, Charles Morris Smith, Francisco M. Benitez, Kun Wang, Hari Nair, Travis A. Reine, Gabor Kiss, Roberto Garcia, Christopher L. Becker
  • Patent number: 9029605
    Abstract: The present invention relates to a method for preparing menthone, starting from isopulegol, using specific homogeneous catalysts.
    Type: Grant
    Filed: September 10, 2013
    Date of Patent: May 12, 2015
    Assignee: BASF SE
    Inventors: Thomas Schaub, Martine Weis, Stefan Rüdenauer
  • Patent number: 9000223
    Abstract: A process for preparing a ketone by conversion of a compound E which contains an epoxy group to the ketone in the presence of a mixture comprising at least one noble metal and at least one metal oxide as a catalyst system, wherein the metal oxide in the catalyst system is at least one of titanium dioxide and zirconium dioxide, and the process is conducted at 0 to 0.9 bar of hydrogen.
    Type: Grant
    Filed: February 27, 2014
    Date of Patent: April 7, 2015
    Assignee: Evonik Industries AG
    Inventors: Kevin Micoine, Martin Roos, Peter Hannen, Harald Haeger, Klaus Bartosch
  • Patent number: 9000224
    Abstract: The present invention relates to a process for the preparation of pillar[5]quinone and further relates to an easy-to-operate and chromatography-free process for the preparation of crystalline pillar[5]quinone by the oxone/iodobenzene-mediated oxidative de-aromatization of readily available 1,4-dimethoxypillar[5]arenes in good yields.
    Type: Grant
    Filed: July 29, 2014
    Date of Patent: April 7, 2015
    Assignee: Council of Scientific & Industrial Research
    Inventors: Jessy Sanjayan Gangadhar, Ishwara Shivakumar Kilingaru
  • Patent number: 8871981
    Abstract: A method for oxidizing an alcohol, wherein oxidation is performed in the presence of a compound represented by the following formula (I) and a bulk oxidant, which enables efficient oxidation of secondary alcohols as well as primary alcohols, and can attain high reaction efficiency even when air is used as a bulk oxidant.
    Type: Grant
    Filed: May 30, 2011
    Date of Patent: October 28, 2014
    Assignee: Tohoku University
    Inventors: Yoshiharu Iwabuchi, Masaki Hayashi
  • Publication number: 20140296577
    Abstract: In a process for producing phenol and cyclohexanone a feed comprising cyclohexylbenzene hydroperoxide and water in an amount from 1 to 15,000 ppm, based upon total weight of feed, is contacted with a cleavage catalyst comprising an aluminosilicate of the FAU type under cleavage conditions effective to convert at least a portion of the cyclohexylbenzene hydroperoxide into phenol and cyclohexanone.
    Type: Application
    Filed: December 15, 2011
    Publication date: October 2, 2014
    Inventors: Kun Wang, Roberto Garcia
  • Publication number: 20140273118
    Abstract: The present invention provides processes, methods, and systems for converting biomass-derived feedstocks to liquid fuels and chemicals. The method generally includes the reaction of a hydrolysate from a biomass deconstruction process with hydrogen and a catalyst to produce a reaction product comprising one of more oxygenated compounds. The process also includes reacting the reaction product with a condensation catalyst to produce C4+ compounds useful as fuels and chemicals.
    Type: Application
    Filed: March 17, 2014
    Publication date: September 18, 2014
    Applicant: Virent, Inc.
    Inventors: Andrew Held, Elizabeth Woods, Randy Cortright, Matthew Gray
  • Publication number: 20140242867
    Abstract: Lignin compositions, products produced from them or containing them, methods to produce them, spinning methods, methods to convert lignin to a conversion product and conversion products produced by the methods are described.
    Type: Application
    Filed: April 4, 2012
    Publication date: August 28, 2014
    Inventors: Robert Jansen, Aharon Eyal, Noa Lapidot, Bassem Hallac, Ziv-Vladimir Belman, Shmuel Kenig
  • Publication number: 20140221674
    Abstract: The invention discloses novel processes for production, enrichment and/or isolation of alpha-tocotrienol from source material comprising at least one non-alpha-tocotrienol, such as natural extracts comprising mixed tocotrienols.
    Type: Application
    Filed: September 26, 2013
    Publication date: August 7, 2014
    Applicant: Edison Pharmaceuticals, Inc.
    Inventors: Kieron E. Wesson, Andrew W. Hinman, Orion D. Jankowski
  • Publication number: 20140187821
    Abstract: In a process for producing a cycloalkylaromatic compound, an aromatic compound and a cyclic olefin are contacted with a first catalyst under conditions effective to produce a reaction product comprising the cycloalkylaromatic compound and at least one non-fused bicyclic by-product. The at least one non-fused bicyclic by-product is then contacted with a second catalyst under conditions effective to convert at least a portion of the at least one non-fused bicyclic by-product to a converted by-product.
    Type: Application
    Filed: October 25, 2011
    Publication date: July 3, 2014
    Applicant: ExxonMobil Chemical Patents Inc.
    Inventors: Kun Wang, Jihad M. Dakka, Stephen Zushma, James R. Lattner, Christopher L. Becker, Tan-Jen Chen
  • Patent number: 8674143
    Abstract: A process for the preparation of 1-ethynyl-3,3-dimethylcyclohexan-1-ol from dimedone by a reaction sequence of reduction and ethynylation and its further transformation into green ketone.
    Type: Grant
    Filed: October 7, 2009
    Date of Patent: March 18, 2014
    Assignee: DSM IP Assets, B.V.
    Inventors: Werner Bonrath, Ulla Letinois, Jan Schütz
  • Publication number: 20140073817
    Abstract: The present invention relates to a method for preparing menthone, starting from isopulegol, using specific homogeneous catalysts.
    Type: Application
    Filed: September 10, 2013
    Publication date: March 13, 2014
    Applicant: BASF SE
    Inventors: Thomas Schaub, Martine Weis, Stefan Rudenauer
  • Patent number: 8664448
    Abstract: The present invention relates to a process for producing an odorless and colorless industrial grade propylene glycol from glycerol obtained during the manufacturing of biodiesel. The process includes hydrogenating the glycerol to form a hydrogenated product, distilling the hydrogenated product to form a glycol product, and contacting the glycol product with a treatment bed. The propylene glycol may be used in various industrial and consumer applications and products such as personal care products.
    Type: Grant
    Filed: June 2, 2009
    Date of Patent: March 4, 2014
    Assignee: Huntsman Petrochemical LLC
    Inventors: Srinivasa Godavarthy, Wei-Yang Su, Ralph M. DiGuilio, Stan Harville, Matthew W. Forkner
  • Patent number: 8519194
    Abstract: In a process for producing cyclohexylbenzene, benzene and hydrogen are fed to at least one reaction zone comprising a catalyst system which comprises a molecular sieve and at least one hydrogenation metal. The MCM-22 family molecular sieve having an X-ray diffraction pattern including d-spacing maxima at 12.4±0.25, 6.9±0.15, 3.57±0.07 and 3.42±0.07 Angstrom, and the hydrogenation metal is selected from the group consisting of palladium, ruthenium, nickel, zinc, tin, cobalt, and combinations of any two or more thereof. Hydroalkylation conditions of temperature and pressure are selected to produce a hydroalkylation conversion in a range of from about 15% to about 75% The benzene and hydrogen are then contacted in the at least one reaction zone under said selected hydroalkylation condition to produce an effluent containing cyclohexylbenzene.
    Type: Grant
    Filed: November 24, 2009
    Date of Patent: August 27, 2013
    Assignee: ExxonMobil Chemical Patents Inc.
    Inventors: Tan-Jen Chen, Francisco M. Benitez, John S. Buchanan, Jane C. Cheng, Jon E. Stanat
  • Publication number: 20130172543
    Abstract: A method for oxidizing an alcohol, wherein oxidation is performed in the presence of a compound represented by the following formula (I) and a bulk oxidant, which enables efficient oxidation of secondary alcohols as well as primary alcohols, and can attain high reaction efficiency even when air is used as a bulk oxidant.
    Type: Application
    Filed: May 30, 2011
    Publication date: July 4, 2013
    Applicant: TOHOKU UNIVERSITY
    Inventors: Yoshiharu Iwabuchi, Masaki Hayashi
  • Publication number: 20130123514
    Abstract: The disclosure relates to catalytically active carbocatalysts, e.g., a graphene oxide or graphite oxide catalyst suitable for use in a variety of chemical transformations. In one embodiment, it relates to a method of catalyzing a chemical reaction of an organic molecule by reacting the organic molecule in the presence of a sufficient amount of graphene oxide or graphite oxide for a time and at a temperature sufficient to allow catalysis of a chemical reaction. According to other embodiments, the reaction may be an oxidation reaction, a hydration reaction, a dehydrogenation reaction, a condensation reaction, or a polymerization reaction. Some reactions may include auto-tandem reactions. The disclosure further provides reaction mixtures containing an organic molecule and graphene oxide or graphite oxide in an amount sufficient to catalyze a reaction of the organic molecule.
    Type: Application
    Filed: May 27, 2011
    Publication date: May 16, 2013
    Applicant: GRAPHEA, INC.
    Inventors: Christopher W. Bielawski, Daniel R. Dreyer, Hong-Peng Jia
  • Patent number: 8394994
    Abstract: The present invention relates to [1] a process for producing a 2-alkyl-2-cycloalken-1-one represented by the following general formula (2), which includes the step of subjecting a 2-(1-hydroxyalkyl)cycloalkan-1-one to dehydration and isomerization in the co-existence of an acid and a platinum group metal catalyst, and [2] a process for producing an alkyl(3-oxo-alkylcycloalkyl)acetate which is useful as a perfume material, using the 2-alkyl-2-cycloalken-1-one: wherein n is an integer of 1 or 2; and R1 and R2 are each independently a hydrogen atom or an alkyl group having 1 to 8 carbon atoms with the proviso that R1 and R2 may form a ring through a carbon atom adjacent thereto.
    Type: Grant
    Filed: April 2, 2009
    Date of Patent: March 12, 2013
    Assignee: Kao Corporation
    Inventors: Makiko Muroi, Atsushi Nagasawa, Kunshi Matsumoto, Mariko Kagaya, Hirotsugu Nishimura, Yoshiharu Ataka
  • Patent number: 8329956
    Abstract: In a process for producing cyclohexylbenzene, benzene and hydrogen are contacted under hydroalkylation conditions with a catalyst system comprising a MCM-22 family molecular sieve and at least one hydrogenation metal. The conditions comprise a temperature of about 140° C. to about 175° C., a pressure of about 135 psig to about 175 psig (931 kPag to 1207 kPag), a hydrogen to benzene molar ratio of about 0.30 to about 0.65 and a weight hourly space velocity of benzene of about 0.26 to about 1.05 hr?1.
    Type: Grant
    Filed: March 1, 2012
    Date of Patent: December 11, 2012
    Assignee: ExxonMobil Chemical Patents Inc.
    Inventors: Jane C. Cheng, Tan-Jen Chen, Prasenjeet Ghosh
  • Publication number: 20120289723
    Abstract: Indene derivatives that are utilizable as intermediates in the synthesis of the vitamin D2 derivative paricalcitol, which is useful as pharmaceutical are efficiently prepared by subjecting a vitamin D2 derivative such as 25-hydroxyvitamin D2 to a two-steps oxidation reaction using an oxidizing agent such as potassium permanganates and sodium periodate in a suitable solvent such as methanol and ethanol.
    Type: Application
    Filed: July 24, 2012
    Publication date: November 15, 2012
    Inventors: Asako TOYODA, Hazuki NAGAI
  • Publication number: 20120283476
    Abstract: A process for the preparation of 1-ethynyl-3,3-dimethylcyclohexan-1-ol from dimedone by a reaction sequence of reduction and ethynylation and its further transformation into green ketone.
    Type: Application
    Filed: October 7, 2009
    Publication date: November 8, 2012
    Inventors: Werner Bonrath, Ulla Letinois, Jan Schütz
  • Publication number: 20120264935
    Abstract: The invention discloses an improved process for the preparation of 2,2,5,5-tetrasubstituted hexane-1,6-dicarbonyl compounds, and in particular diethyl 2,2,5,5-tetramethylhexanedioate and dimethyl 2,2,5,5-tetramethylhexanedioate, by the alkylation of 1,2-difunctional ethane compounds with enolates of carbonyl compounds. The process provides higher yields and greater synthetic brevity than existing processes.
    Type: Application
    Filed: December 21, 2010
    Publication date: October 18, 2012
    Applicant: THE UNIVERSITY OF READING
    Inventors: Francis William Lewis, Laurence Marius Harwood, Michael James Hudson
  • Patent number: 8247627
    Abstract: In a process for producing phenol and/or cyclohexanone, benzene and hydrogen are contacted with a first catalyst in a hydroalkylation step to produce a first effluent stream comprising cyclohexylbenzene, cyclohexane, and unreacted benzene. At least part of the first effluent stream is supplied to a first separation system to divide the first effluent stream part into a cyclohexylbenzene-rich stream and a C6 product stream comprising unreacted benzene and cyclohexane.
    Type: Grant
    Filed: March 16, 2009
    Date of Patent: August 21, 2012
    Assignee: ExxonMobil Chemical Patents Inc.
    Inventors: Jihad M. Dakka, J. Scott Buchanan, Jane C. Cheng, Tan-Jen Chen, Lorenzo C. DeCaul, Terry E. Helton, Jon E. Stanat, Francisco M. Benitez
  • Patent number: 8222459
    Abstract: In a process for producing cyclohexanone, cyclohexylbenzene is oxidized to produce cyclohexylbenzene hydroperoxide and then the resultant cyclohexylbenzene hydroperoxide is cleaved to produce an effluent stream comprising phenol and cyclohexanone. At least a portion of the effluent stream is then fed to at least one hydrogenation reaction zone, where the effluent stream portion is contacted with hydrogen in the presence of a hydrogenation catalyst under conditions effective to convert at least part of the phenol in the effluent portion into cyclohexanone.
    Type: Grant
    Filed: February 19, 2009
    Date of Patent: July 17, 2012
    Assignee: Exxonmobil Chemical Patents Inc.
    Inventors: Jihad M. Dakka, John S. Buchanan, James R. Lattner, Sadi Mizrahi
  • Patent number: 8178728
    Abstract: In a process for producing cyclohexylbenzene, benzene and hydrogen are contacted under hydroalkylation conditions with a catalyst system comprising a MCM-22 family molecular sieve and at least one hydrogenation metal. The conditions comprise a temperature of about 140° C. to about 175° C., a pressure of about 135 psig to about 175 psig (931 kPag to 1207 kPag), a hydrogen to benzene molar ratio of about 0.30 to about 0.65 and a weight hourly space velocity of benzene of about 0.26 to about 1.05 hr?1.
    Type: Grant
    Filed: February 24, 2009
    Date of Patent: May 15, 2012
    Assignee: ExxonMobil Chemical Patents Inc.
    Inventors: Jane C. Cheng, Tan-Jen Chen, Prasenjeet Ghosh
  • Publication number: 20120010281
    Abstract: Infections caused by Mycobacterium tuberculosis kill more than 1.8 million people each year. While the persistence of this pathogenic bacterial species and the emergence of multidrug resistant strains have created an urgent need for new TB therapies, a new TB-specific drug has not been developed in over 40 years. The disclosure herein provides short and scalable syntheses of small molecules, and small molecules as new therapeutics for eradicating this life threatening pathogen.
    Type: Application
    Filed: June 22, 2011
    Publication date: January 12, 2012
    Applicant: THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Erik J. Sorensen, Stephen D. Lotesta, Junjia Liu, Emma V. Yates, Maurice A. Marsini
  • Patent number: 7910779
    Abstract: In a process for producing cyclohexylbenzene, benzene and hydrogen are fed to at least one reaction zone. The benzene and hydrogen are then contacted in the at least one reaction zone under hydroalkylation conditions with a catalyst system comprising a molecular sieve having an X-ray diffraction pattern including d-spacing maxima at 12.4±0.25, 6.9±0.15, 3.57±0.07 and 3.42±0.07 Angstrom, and at least one hydrogenation metal to produce an effluent containing cyclohexylbenzene. The catalyst system has an acid-to-metal molar ratio of from about 75 to about 750.
    Type: Grant
    Filed: October 14, 2010
    Date of Patent: March 22, 2011
    Assignee: ExxonMobil Chemical Patents Inc.
    Inventors: Tan-Jen Chen, Jane C. Cheng, Terry E. Helton, John Scott Buchanan
  • Patent number: 7910778
    Abstract: In a process for producing cyclohexylbenzene, benzene and hydrogen are contacted with a catalyst under hydroalkylation conditions to produce an effluent containing cyclohexylbenzene. The catalyst comprises a composite of a molecular sieve, an inorganic oxide different from said molecular sieve and at least one hydrogenation metal, wherein at least 50 wt % of said hydrogenation metal is supported on the inorganic oxide.
    Type: Grant
    Filed: July 11, 2008
    Date of Patent: March 22, 2011
    Assignee: ExxonMobil Chemical Patents Inc.
    Inventors: Tan-Jen Chen, John Scott Buchanan, Jane Chi-ya Cheng, Terry E. Helton
  • Patent number: 7906685
    Abstract: In a process for producing cyclohexylbenzene, benzene and hydrogen are fed to at least one reaction zone. The benzene and hydrogen are then contacted in the at least one reaction zone under hydroalkylation conditions with a catalyst system comprising a molecular sieve having an X-ray diffraction pattern including d-spacing maxima at 12.4±0.25, 6.9±0.15, 3.57±0.07 and 3.42±0.07 Angstrom, and at least one hydrogenation metal to produce an effluent containing cyclohexylbenzene. The ratio of the total number of moles of hydrogen fed to said at least one reaction zone to the number of moles of benzene fed to said at least one reaction zone is between 0.4 and 0.9:1.
    Type: Grant
    Filed: August 12, 2008
    Date of Patent: March 15, 2011
    Assignee: ExxonMobil Chemical Patents Inc.
    Inventors: Tan-Jen Chen, Francisco M. Benitez, Jane C. Cheng, Jon E. Stanat, John Scott Buchanan
  • Publication number: 20110015412
    Abstract: The invention relates to a process of reacting a primary allylic alcohol with a compound containing a) a metal selected from the group consisting of Ag, Au, Ce, Mn, Ni, Ru, Re, Zn and Co preferably Ag and b) an oxidant like TEMPO (2,2?,6,6?-tetra-methylpiperidin-1-oxyl) or its derivates and c) a co-oxidants selected from the group of peroxodisulfates (PDS), H2505, H2O2, NaOCl, O2, KOCl, and air.
    Type: Application
    Filed: February 15, 2008
    Publication date: January 20, 2011
    Applicant: DSM IP ASSETS B.V.
    Inventors: Werner Bonrath, Jean-Francois Eckhardt, Manfred L. Eggersdorfer, Ramona Hinze, Wolfgang F. Hölderich, Michael H. Valkenberg
  • Patent number: 7847128
    Abstract: In a process for producing cyclohexylbenzene, benzene and hydrogen are fed to at least one reaction zone. The benzene and hydrogen are then contacted in the at least one reaction zone under hydroalkylation conditions with a catalyst system comprising a molecular sieve having an X-ray diffraction pattern including d-spacing maxima at 12.4±0.25, 6.9±0.15, 3.57±0.07 and 3.42±0.07 Angstrom, and at least one hydrogenation metal to produce an effluent containing cyclohexylbenzene. The catalyst system has an acid-to-metal molar ratio of from about 75 to about 750.
    Type: Grant
    Filed: August 12, 2008
    Date of Patent: December 7, 2010
    Assignee: ExxonMobil Chemical Patents Inc.
    Inventors: Tan-Jen Chen, Jane C. Cheng, Terry E. Helton, John Scott Buchanan
  • Publication number: 20100179351
    Abstract: In a process for producing cyclohexylbenzene, benzene and hydrogen are fed to at least one reaction zone. The benzene and hydrogen are then contacted in the at least one reaction zone under hydroalkylation conditions with a catalyst system comprising a molecular sieve having an X-ray diffraction pattern including d-spacing maxima at 12.4±0.25, 6.9±0.15, 3.57±0.07 and 3.42±0.07 Angstrom, and at least one hydrogenation metal to produce an effluent containing cyclohexylbenzene. The catalyst system has an acid-to-metal molar ratio of from about 75 to about 750.
    Type: Application
    Filed: August 12, 2008
    Publication date: July 15, 2010
    Inventors: Tan-Jen Chen, Jane C. Cheng, Terry E. Helton, John Scott Buchanan
  • Patent number: 7652171
    Abstract: The present invention relates to a process for the cleavage of dialkoxyalkanes to give corresponding aldehydes or ketones, where the cleavage is carried out in the presence of at least one ionic liquid of the general formula K+A?.
    Type: Grant
    Filed: January 25, 2007
    Date of Patent: January 26, 2010
    Assignee: Merck Patent GmbH
    Inventors: Nikolai (Mykola) Ignatyev, Karsten Koppe, Hermann Josef Frohn, Peter Barthen
  • Publication number: 20090177002
    Abstract: Indene derivatives that are utilizable as intermediates in the synthesis of the vitamin D2 derivative paricalcitol, which is useful as pharmaceutical are efficiently prepared by subjecting a vitamin D2 derivative such as 25-hydroxyvitamin D2 to a two-steps oxidation reaction using an oxidizing agent such as potassium permanganates and sodium periodate in a suitable solvent such as methanol and ethanol.
    Type: Application
    Filed: March 14, 2007
    Publication date: July 9, 2009
    Inventors: Asako Toyoda, Hazuki Nagai
  • Publication number: 20090143581
    Abstract: The syntheses of the natural products, avrainvillamide and stephacidin B, are provided. The ?,?-unsaturated nitrone functionality of avrainvillamide and its 3-alkylidene-3H-indole 1-oxide core is shown to covalently and reversibly bond to heteroatom-based nucleophiles. This capability may allow these molecules to bind active site nucleophiles and may provide the basis for designing potent and selective enzyme inhibitors. Both avrainvillamide and its dimer stephacidin B have been reported to exhibit antiproliferative activity, and avrainvillamide has been reported to exhibit antimicrobial activity against multi-drug resistant bacteria. Avrainvillamide has been found to target cytoskeleton-linking membrane protein (CLIMP-63) thereby preventing cells from undergoing mitosis. The invention provides syntheses of these natural products as well as analogs of these natural products and their functional cores.
    Type: Application
    Filed: March 17, 2006
    Publication date: June 4, 2009
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Andrew G. Myers, Seth B. Herzon, Jeremy Earle Wulff, Romain Siegrist, Jakub Svenda, Matthew Alan Zajac
  • Publication number: 20090054693
    Abstract: Chemical production processes are provided that can include exposing a reactant composition to a catalyst composition to form a product composition.
    Type: Application
    Filed: August 24, 2007
    Publication date: February 26, 2009
    Inventors: Thomas H. Peterson, Alan H. Zacher, Michel J. Gray, James F. White, Todd A. Werpy
  • Publication number: 20090054694
    Abstract: Chemical production processes are provided that include exposing a reactant composition to a catalyst composition to form a product composition, with the reactant composition including a multihydric alcohol compound and the catalyst composition being effective to dehydrate at least a portion of the multihydric alcohol compound. Embodiments of the process provide that the reactant composition is exposed to the catalyst composition for less than about 0.25 seconds and/or that the catalyst is maintained at a temperature of from about 280° C. to about 320° C. Processes utilizing a reactant composition including a multihydric alcohol compound and an inert compound are also provided.
    Type: Application
    Filed: August 24, 2007
    Publication date: February 26, 2009
    Inventors: Thomas H. Peterson, Johnathan E. Holladay, Alan H. Zacher, Michel J. Gray, Todd A. Werpy, James F. White
  • Publication number: 20090012329
    Abstract: The present invention relates to a process for the cleavage of dialkoxyalkanes to give corresponding aldehydes or ketones, where the cleavage is carried out in the presence of at least one ionic liquid of the general formula K+A?.
    Type: Application
    Filed: January 25, 2007
    Publication date: January 8, 2009
    Inventors: Nikolai (Mykola) Ignatyev, Karsten Koppe, Hermann Josef Frohn, Peter Barthen
  • Patent number: 7468463
    Abstract: The present invention relates to a process for preparing optically active aldehydes or ketones which have from 3 to 25 carbon atoms and at least one racemizable stereocenter by catalytic dehydrogenation of the corresponding optically active primary or secondary alcohols in the gas phase in the presence of a catalyst.
    Type: Grant
    Filed: March 4, 2005
    Date of Patent: December 23, 2008
    Assignee: BASF AG
    Inventors: Thorsten Johann, Oliver Löber, Eike Johannes Bergner, Klaus Ebel, Klaus Harth, Christian Walsdorff
  • Patent number: 7423184
    Abstract: A method of making a carbonyl compound comprises contacting a compound comprising a secondary hydroxyl group with a basic metal oxide catalyst at a temperature sufficient to maintain the compound comprising a secondary hydroxyl group in a vapor phase.
    Type: Grant
    Filed: August 29, 2005
    Date of Patent: September 9, 2008
    Assignee: Sabic Innovative Plastics IP B.V.
    Inventors: Hugo Ingelbrecht, Arun Kumar, Ashok Ramakrishnan Menon, Pradeep Nadkarni, Rupesh Pawar
  • Patent number: 7402712
    Abstract: Provided by the present invention are an adamantyl vinyl ether compound which is useful as a monomer for functional resins in the photolithography field or a raw material therefor and medical and agricultural intermediates and a production process for the same. The present invention relates to a production process for an adamantyl vinyl ether compound, characterized by subjecting an adamantyl vinyl ether compound having a specific structure and alcohol having an eliminating group in a ? position to chloroalkyl-etherification, then subjecting it to etherification to form an adamantyl group-containing ether and then subjecting it to vinyl-etherification.
    Type: Grant
    Filed: June 8, 2004
    Date of Patent: July 22, 2008
    Assignee: Idemitsu Petrochemical Co., Ltd.
    Inventors: Naoyoshi Hatakeyama, Shinji Tanaka, Hidetoshi Ono, Kouichi Kodoi
  • Patent number: 7396961
    Abstract: The present invention relates to a process for decomposing organic hydroperoxides in the presence of a catalyst. It provides a process for decomposing organic hydroperoxides in the presence of a catalyst into a mixture of alcohols and ketones, in which the catalyst comprises at least one ruthenium-based catalytically active metallic element incorporated into a solid support chosen from the group comprising metal oxides and carbon blacks, such as the carbon blacks obtained by the pyrolysis of organic compounds. The process of the invention is especially useful in the decomposition of important chemical intermediates such as cyclohexyl hydroperoxide.
    Type: Grant
    Filed: January 20, 2006
    Date of Patent: July 8, 2008
    Assignee: Rhodia Polyamide Intermediates
    Inventors: Didier Bonnet, Eric Fache, Aline Seigneurin
  • Patent number: 7348147
    Abstract: The present invention relates to a method of detecting nucleic acids comprising suspending at least one recognizable target nucleic acid in a suspending solution containing polymeric particles marked with a probe, wherein the probe has an affinity for the target nucleic acid, adding a recognition unit-peroxidase conjugate marker to the suspending solution, forming a complex of the polymeric particles marked with a probe, the target nucleic acid and the recognition unit-peroxidase conjugate marker, contacting the suspending solution with a gelatin surface, adding a developer to the suspending solution in contact with the gelatin surface in the presence of phenol to attach the complex to the gelatin surface, washing the gelatin surface, and detecting the complex attached to the gelatin surface.
    Type: Grant
    Filed: November 15, 2004
    Date of Patent: March 25, 2008
    Assignee: Carestream Health, Inc.
    Inventors: Tiecheng A. Qiao, Brian J. Kelley
  • Patent number: 7332632
    Abstract: The method for producing an aldehyde or ketone compound from a corresponding primary or secondary alcohol at relatively high temperature within a short time with a high yield including a step (1) of reacting a sulfoxide compound with an activating agent to produce an activation reaction product; a step (2) of reacting the activation reaction product with a primary or secondary alcohol to produce an alkoxysulfonium salt; and a step (3) of reacting the reaction product with a base to produce an aldehyde or ketone; wherein at least one of the steps, preferably the step (1) and step (2), are carried out by using a microreactor.
    Type: Grant
    Filed: November 22, 2004
    Date of Patent: February 19, 2008
    Assignee: Ubē Industries, Ltd.
    Inventors: Kikuo Ataka, Hiroyuki Miyata, Tatsuya Kawaguchi, Junichi Yoshida, Kazuhiro Mae
  • Patent number: 7208634
    Abstract: A method for preparing an aldehyde or ketone by oxidizing a primary or secondary alcohol in the presence of a nitroxyl radical compound and a co-oxidant in an organic solvent, which process is characterized in using an organic N-bromoamide compound or a combination of N-chlorosuccinimide and a compound having bromide ion as the co-oxidant.
    Type: Grant
    Filed: December 1, 2005
    Date of Patent: April 24, 2007
    Assignee: Daiso Co., Ltd.
    Inventors: Kimitaka Igi, Makoto Hirata, Masafumi Mikami
  • Patent number: 7202205
    Abstract: Processes for making particularly branched, especially monomethyl-branched or nongeminal dimethyl-branched surfactants used in cleaning products; preferred processes comprising particular combinations of two or more adsorptive separation steps and, more preferably, particular OXO and/or alkylation steps; products of such processes, including certain modified primary OXO alcohols and/or alkylbenzenes, modified primary OXO alcohol-derived alkoxylated alcohols, alkylsulfates and/or alkoxysulfates; alkylbenzensulfonate surfactants, and consumer cleaning products, especially laundry detergents, containing them. Preferred processes herein more specifically use specific, unconventional sequences of sorptive separation steps to secure certain branched hydrocarbon fractions which are used in further process steps to make olefins useful in OXO processes or as alkylating agents for arenes or for other useful surfactant-making purposes.
    Type: Grant
    Filed: September 1, 1999
    Date of Patent: April 10, 2007
    Inventors: Daniel Stedman Connor, Jeffrey John Scheibel, James Charles Theophile Roger Burckett-St. Laurent, Thomas Anthony Cripe, Kevin Lee Kott, Phillip Kyle Vinson
  • Patent number: 7179943
    Abstract: Bicyclic amide derivatives of formula (I) or tautomers or pharmaceutically acceptable salts thereof or both are provided: Also provided are processes for preparing the bicyclic amide derivatives as well as pharmaceutical compositions containing the same and therapeutic uses. The bicyclic amide derivatives are useful for treating a variety of conditions associated with the abnormal modulation of one or more Kv1.1 voltage-gated potassium channels.
    Type: Grant
    Filed: June 13, 2005
    Date of Patent: February 20, 2007
    Assignee: Wyeth
    Inventors: Wayne E. Childers, Jerome C. Wu, Callain Y. Kim, Edward J. Podlesny
  • Patent number: 7169954
    Abstract: A ruthenium-carrying alumina, which is prepared by suspending alumina in a solution containing trivalent ruthenium and adding a base to the suspension, is provided. This ruthenium-carrying alumina is useful as a catalyst for oxidizing alcohols by contacting the alcohols with molecular oxygen, and can be used for oxidizing the alcohols at a high conversion to produce ketones, aldehydes, carboxylic acids, etc. with good productivity.
    Type: Grant
    Filed: April 25, 2003
    Date of Patent: January 30, 2007
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Noritaka Mizuno, Kazuya Yamaguchi, Hajime Ishida